Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transcription coregulator activity	SUPT20HL1 NCOA3 ARID1B SUPT20H SND1 SUPT20HL2 ACTL6B EP300	1.42e-04	562	55	8	GO:0003712
GeneOntologyMolecularFunction	molecular adaptor activity	SUPT20HL1 NCOA3 ARID1B SUPT20H SND1 GAB3 IRAK2 SUPT20HL2 ACTL6B ADAM10 LDLR EP300	2.61e-04	1356	55	12	GO:0060090
GeneOntologyMolecularFunction	K48-linked polyubiquitin modification-dependent protein binding	RNF31 UBQLN4	3.31e-04	10	55	2	GO:0036435
GeneOntologyMolecularFunction	structural constituent of cytoskeleton	ACTL7B TUBG2 ACTL6B TUBG1	4.52e-04	130	55	4	GO:0005200
GeneOntologyMolecularFunction	polyubiquitin modification-dependent protein binding	UBQLN1 RNF31 UBQLN4	5.76e-04	59	55	3	GO:0031593
GeneOntologyMolecularFunction	metalloexopeptidase activity	AEBP1 ADAM10 ENPEP	9.50e-04	70	55	3	GO:0008235
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	SUPT20HL1 NCOA3 ARID1B SUPT20H SND1 GAB3 IRAK2 SUPT20HL2 ACTL6B EP300	1.12e-03	1160	55	10	GO:0030674
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	RNASE4 SND1	1.37e-03	20	55	2	GO:0016894
GeneOntologyMolecularFunction	K48-linked deubiquitinase activity	USP36 USP9X	1.51e-03	21	55	2	GO:1990380
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	NCOA3 EP300	1.51e-03	21	55	2	GO:0042975
GeneOntologyMolecularFunction	modification-dependent protein binding	UBQLN1 RNF31 UBQLN4 EP300	2.49e-03	206	55	4	GO:0140030
GeneOntologyMolecularFunction	exopeptidase activity	AEBP1 ADAM10 ENPEP	3.47e-03	110	55	3	GO:0008238
GeneOntologyBiologicalProcess	hexose metabolic process	SUPT20HL1 SUPT20H MAN2B2 SUPT20HL2 FUT2 PC EP300	1.00e-05	284	55	7	GO:0019318
GeneOntologyBiologicalProcess	gluconeogenesis	SUPT20HL1 SUPT20H SUPT20HL2 PC EP300	1.16e-05	111	55	5	GO:0006094
GeneOntologyBiologicalProcess	hexose biosynthetic process	SUPT20HL1 SUPT20H SUPT20HL2 PC EP300	1.37e-05	115	55	5	GO:0019319
GeneOntologyBiologicalProcess	monosaccharide biosynthetic process	SUPT20HL1 SUPT20H SUPT20HL2 PC EP300	1.76e-05	121	55	5	GO:0046364
GeneOntologyBiologicalProcess	monosaccharide metabolic process	SUPT20HL1 SUPT20H MAN2B2 SUPT20HL2 FUT2 PC EP300	1.77e-05	310	55	7	GO:0005996
GeneOntologyBiologicalProcess	regulation of DNA repair	SUPT20HL1 ARID1B SUPT20H UBQLN4 SUPT20HL2 ACTL6B	3.64e-05	234	55	6	GO:0006282
GeneOntologyBiologicalProcess	DNA damage response	SUPT20HL1 ARID1B SUPT20H WDR33 USP9X UBQLN4 SUPT20HL2 ACTL6B REV3L MLST8 EP300	3.78e-05	959	55	11	GO:0006974
GeneOntologyBiologicalProcess	regulation of gluconeogenesis	SUPT20HL1 SUPT20H SUPT20HL2 EP300	3.85e-05	71	55	4	GO:0006111
GeneOntologyBiologicalProcess	carbohydrate biosynthetic process	SUPT20HL1 SUPT20H SUPT20HL2 FUT2 PC EP300	4.92e-05	247	55	6	GO:0016051
GeneOntologyBiologicalProcess	DNA repair	SUPT20HL1 ARID1B SUPT20H WDR33 USP9X UBQLN4 SUPT20HL2 ACTL6B REV3L	4.93e-05	648	55	9	GO:0006281
GeneOntologyBiologicalProcess	positive regulation of gluconeogenesis	SUPT20HL1 SUPT20H SUPT20HL2	8.42e-05	32	55	3	GO:0045722
GeneOntologyBiologicalProcess	regulation of small molecule metabolic process	SUPT20HL1 SUPT20H SUPT20HL2 MLST8 NOS2 LDLR EP300	1.48e-04	434	55	7	GO:0062012
GeneOntologyBiologicalProcess	positive regulation of small molecule metabolic process	SUPT20HL1 SUPT20H SUPT20HL2 MLST8 NOS2	1.58e-04	192	55	5	GO:0062013
GeneOntologyBiologicalProcess	regulation of cellular response to stress	SUPT20HL1 ARID1B SUPT20H UBQLN1 UBQLN4 SUPT20HL2 ACTL6B EP300	1.74e-04	598	55	8	GO:0080135
GeneOntologyBiologicalProcess	positive regulation of carbohydrate metabolic process	SUPT20HL1 SUPT20H SUPT20HL2 MLST8	1.77e-04	105	55	4	GO:0045913
GeneOntologyBiologicalProcess	neuron projection extension	WDR36 PRICKLE1 USP9X EIF2B2 EP300	2.24e-04	207	55	5	GO:1990138
GeneOntologyBiologicalProcess	negative regulation of autophagy	USP36 UBQLN4 MLST8 EP300	2.27e-04	112	55	4	GO:0010507
GeneOntologyBiologicalProcess	cell growth	NCOA3 WDR36 PRICKLE1 USP9X EIF2B2 MLST8 ADAM10 EP300	2.36e-04	625	55	8	GO:0016049
GeneOntologyBiologicalProcess	positive regulation of cell growth	NCOA3 EIF2B2 MLST8 ADAM10 EP300	2.56e-04	213	55	5	GO:0030307
GeneOntologyBiologicalProcess	carbohydrate metabolic process	SUPT20HL1 SUPT20H MAN2B2 SUPT20HL2 FUT2 MLST8 PC EP300	2.94e-04	646	55	8	GO:0005975
GeneOntologyBiologicalProcess	positive regulation of immune system process	ARID1B UBQLN1 RNF31 STMP1 USP9X EIF2B2 IRAK2 ACTL6B ADAM10 NOS2 EP300	3.72e-04	1242	55	11	GO:0002684
GeneOntologyBiologicalProcess	regulation of carbohydrate metabolic process	SUPT20HL1 SUPT20H SUPT20HL2 MLST8 EP300	3.72e-04	231	55	5	GO:0006109
GeneOntologyBiologicalProcess	cellular catabolic process	USP36 SUPT20H UBQLN1 ACAD11 RNF31 UBQLN4 MLST8 NOS2 ENPEP LDLR EP300	4.01e-04	1253	55	11	GO:0044248
GeneOntologyBiologicalProcess	regulation of carbohydrate biosynthetic process	SUPT20HL1 SUPT20H SUPT20HL2 EP300	4.25e-04	132	55	4	GO:0043255
GeneOntologyBiologicalProcess	regulation of glucose metabolic process	SUPT20HL1 SUPT20H SUPT20HL2 EP300	4.49e-04	134	55	4	GO:0010906
GeneOntologyBiologicalProcess	axon extension	WDR36 USP9X EIF2B2 EP300	4.62e-04	135	55	4	GO:0048675
GeneOntologyBiologicalProcess	glucose metabolic process	SUPT20HL1 SUPT20H SUPT20HL2 PC EP300	4.78e-04	244	55	5	GO:0006006
GeneOntologyBiologicalProcess	sister chromatid segregation	ARID1B PRICKLE1 TUBG2 ACTL6B TUBG1	5.73e-04	254	55	5	GO:0000819
GeneOntologyBiologicalProcess	monocyte activation	ADAM10 FER1L5	6.22e-04	14	55	2	GO:0042117
GeneOntologyBiologicalProcess	immune response-activating signaling pathway	UBQLN1 RNF31 STMP1 USP9X EIF2B2 IRAK2 EP300	6.38e-04	553	55	7	GO:0002757
GeneOntologyBiologicalProcess	regulation of autophagy	USP36 UBQLN1 RNF31 UBQLN4 MLST8 EP300	6.66e-04	400	55	6	GO:0010506
GeneOntologyBiologicalProcess	positive regulation of glucose metabolic process	SUPT20HL1 SUPT20H SUPT20HL2	6.66e-04	64	55	3	GO:0010907
GeneOntologyBiologicalProcess	regulation of protein catabolic process	UBQLN1 PRICKLE1 USP9X UBQLN4 NOS2 LDLR	7.29e-04	407	55	6	GO:0042176
GeneOntologyBiologicalProcess	negative regulation of catabolic process	USP36 USP9X UBQLN4 MLST8 NOS2 EP300	8.37e-04	418	55	6	GO:0009895
GeneOntologyCellularComponent	peptidase complex	SUPT20HL1 SUPT20H UBQLN1 PRICKLE1 UBQLN4 SUPT20HL2	1.33e-06	133	55	6	GO:1905368
GeneOntologyCellularComponent	histone acetyltransferase complex	SUPT20HL1 SUPT20H SUPT20HL2 ACTL6B EP300	4.81e-06	94	55	5	GO:0000123
GeneOntologyCellularComponent	intracellular protein-containing complex	SUPT20HL1 SUPT20H UBQLN1 RNF31 PRICKLE1 UBQLN4 FBXW5 SUPT20HL2 ACTL6B REV3L MLST8 EP300	6.58e-06	972	55	12	GO:0140535
GeneOntologyCellularComponent	protein acetyltransferase complex	SUPT20HL1 SUPT20H SUPT20HL2 ACTL6B EP300	7.90e-06	104	55	5	GO:0031248
GeneOntologyCellularComponent	acetyltransferase complex	SUPT20HL1 SUPT20H SUPT20HL2 ACTL6B EP300	9.93e-06	109	55	5	GO:1902493
GeneOntologyCellularComponent	SAGA complex	SUPT20HL1 SUPT20H SUPT20HL2	3.80e-05	25	55	3	GO:0000124
GeneOntologyCellularComponent	SAGA-type complex	SUPT20HL1 SUPT20H SUPT20HL2	1.47e-04	39	55	3	GO:0070461
GeneOntologyCellularComponent	bBAF complex	ARID1B ACTL6B	3.02e-04	10	55	2	GO:0140092
GeneOntologyCellularComponent	brahma complex	ARID1B ACTL6B	6.06e-04	14	55	2	GO:0035060
GeneOntologyCellularComponent	proteasome complex	UBQLN1 PRICKLE1 UBQLN4	7.33e-04	67	55	3	GO:0000502
GeneOntologyCellularComponent	nBAF complex	ARID1B ACTL6B	7.97e-04	16	55	2	GO:0071565
GeneOntologyCellularComponent	gamma-tubulin complex	TUBG2 TUBG1	1.38e-03	21	55	2	GO:0000930
GeneOntologyCellularComponent	pericentriolar material	TUBG2 TUBG1	2.46e-03	28	55	2	GO:0000242
GeneOntologyCellularComponent	endopeptidase complex	UBQLN1 PRICKLE1 UBQLN4	2.46e-03	102	55	3	GO:1905369
GeneOntologyCellularComponent	SWI/SNF complex	ARID1B ACTL6B	2.82e-03	30	55	2	GO:0016514
GeneOntologyCellularComponent	transferase complex	SUPT20HL1 SUPT20H RNF31 FBXW5 SUPT20HL2 ACTL6B REV3L EP300	3.51e-03	963	55	8	GO:1990234
MousePheno	incomplete somite formation	SUPT20HL1 SUPT20H SUPT20HL2 REV3L EP300	3.40e-07	44	47	5	MP:0001689
MousePheno	abnormal left-right axis symmetry of the somites	SUPT20HL1 SUPT20H SUPT20HL2	1.97e-06	8	47	3	MP:0005224
MousePheno	abnormal gastrulation movements	SUPT20HL1 SUPT20H SUPT20HL2	4.20e-06	10	47	3	MP:0002174
MousePheno	abnormal mesenchyme morphology	SUPT20HL1 SUPT20H SUPT20HL2 REV3L ADAM10	6.87e-06	80	47	5	MP:0006301
MousePheno	abnormal paraxial mesoderm morphology	SUPT20HL1 SUPT20H SUPT20HL2 ADAM10	9.38e-06	40	47	4	MP:0008029
MousePheno	abnormal vitelline vasculature morphology	SUPT20HL1 SUPT20H SUPT20HL2 REV3L MLST8 ADAM10 EP300	1.23e-05	235	47	7	MP:0003229
MousePheno	impaired somite development	SUPT20HL1 SUPT20H SUPT20HL2 REV3L EP300	2.48e-05	104	47	5	MP:0009768
MousePheno	failure of initiation of embryo turning	SUPT20HL1 SUPT20H USP9X SUPT20HL2	3.62e-05	56	47	4	MP:0004180
MousePheno	abnormal mesoderm morphology	SUPT20HL1 SUPT20H PRICKLE1 SUPT20HL2 ADAM10	6.46e-05	127	47	5	MP:0014141
MousePheno	failure of chorioallantoic fusion	SUPT20HL1 SUPT20H USP9X SUPT20HL2	7.36e-05	67	47	4	MP:0009657
MousePheno	abnormal somite development	SUPT20HL1 SUPT20H SUPT20HL2 REV3L ADAM10 EP300	9.35e-05	222	47	6	MP:0001688
MousePheno	abnormal embryo turning	SUPT20HL1 SUPT20H USP9X SUPT20HL2 REV3L EP300	1.83e-04	251	47	6	MP:0001700
MousePheno	abnormal germ layer morphology	SUPT20HL1 SUPT20H PRICKLE1 SUPT20HL2 ADAM10	1.98e-04	161	47	5	MP:0014138
MousePheno	abnormal chorioallantoic fusion	SUPT20HL1 SUPT20H USP9X SUPT20HL2	2.32e-04	90	47	4	MP:0002824
MousePheno	abnormal cardiovascular development	SUPT20HL1 SUPT20H PRICKLE1 USP9X SUPT20HL2 REV3L MLST8 ADAM10 NOS2 EP300	2.72e-04	802	47	10	MP:0002925
MousePheno	embryo tissue necrosis	SUPT20HL1 SUPT20H SUPT20HL2	3.23e-04	40	47	3	MP:0013241
MousePheno	abnormal vascular development	SUPT20HL1 SUPT20H SUPT20HL2 REV3L MLST8 ADAM10 NOS2 EP300	4.01e-04	542	47	8	MP:0000259
MousePheno	abnormal spatial reference memory	ARID1B SLITRK2 PRICKLE1 LDLR	4.49e-04	107	47	4	MP:0008414
Domain	Spt20	SUPT20H SUPT20HL2	7.60e-06	2	52	2	IPR021950
Domain	Spt20	SUPT20H SUPT20HL2	7.60e-06	2	52	2	PF12090
Domain	Gamma_tubulin	TUBG2 TUBG1	7.60e-06	2	52	2	IPR002454
Domain	Nuc_rcpt_coact	NCOA3 EP300	1.13e-04	6	52	2	IPR009110
Domain	Ubiquilin	UBQLN1 UBQLN4	1.13e-04	6	52	2	IPR015496
Domain	UBA	UBQLN1 RNF31 UBQLN4	1.36e-04	36	52	3	PF00627
Domain	UBA	UBQLN1 RNF31 UBQLN4	2.49e-04	44	52	3	IPR015940
Domain	UBA	UBQLN1 RNF31 UBQLN4	3.03e-04	47	52	3	PS50030
Domain	STI1	UBQLN1 UBQLN4	3.37e-04	10	52	2	SM00727
Domain	STI1_HS-bd	UBQLN1 UBQLN4	3.37e-04	10	52	2	IPR006636
Domain	UBA-like	UBQLN1 RNF31 UBQLN4	7.52e-04	64	52	3	IPR009060
Domain	6-PGluconate_DH_C-like	UBQLN1 UBQLN4	1.26e-03	19	52	2	IPR008927
Domain	-	TUBG2 TUBG1	1.40e-03	20	52	2	3.30.1330.20
Domain	-	TUBG2 TUBG1	1.54e-03	21	52	2	1.10.287.600
Domain	Tubulin_C	TUBG2 TUBG1	1.69e-03	22	52	2	SM00865
Domain	Tubulin_C	TUBG2 TUBG1	1.69e-03	22	52	2	PF03953
Domain	Tubulin/FtsZ_2-layer-sand-dom	TUBG2 TUBG1	1.69e-03	22	52	2	IPR018316
Domain	-	TUBG2 TUBG1	1.69e-03	22	52	2	3.40.50.1440
Domain	Tubulin_C	TUBG2 TUBG1	1.85e-03	23	52	2	IPR023123
Domain	TUBULIN	TUBG2 TUBG1	1.85e-03	23	52	2	PS00227
Domain	Tubulin	TUBG2 TUBG1	1.85e-03	23	52	2	IPR000217
Domain	Tub_FtsZ_C	TUBG2 TUBG1	1.85e-03	23	52	2	IPR008280
Domain	Tubulin	TUBG2 TUBG1	1.85e-03	23	52	2	SM00864
Domain	Tubulin_CS	TUBG2 TUBG1	1.85e-03	23	52	2	IPR017975
Domain	Tubulin_FtsZ_GTPase	TUBG2 TUBG1	2.02e-03	24	52	2	IPR003008
Domain	Tubulin	TUBG2 TUBG1	2.02e-03	24	52	2	PF00091
Domain	UBA	UBQLN1 UBQLN4	3.15e-03	30	52	2	SM00165
Domain	Actin	ACTL7B ACTL6B	3.36e-03	31	52	2	IPR004000
Domain	Actin	ACTL7B ACTL6B	3.36e-03	31	52	2	PF00022
Domain	ACTIN	ACTL7B ACTL6B	3.36e-03	31	52	2	SM00268
Domain	UBIQUITIN_1	UBQLN1 UBQLN4	4.76e-03	37	52	2	PS00299
Domain	WD40	WDR36 WDR33 FBXW5 MLST8	5.81e-03	259	52	4	PF00400
Domain	UBQ	UBQLN1 UBQLN4	6.38e-03	43	52	2	SM00213
Domain	WD40	WDR36 WDR33 FBXW5 MLST8	6.54e-03	268	52	4	SM00320
Pubmed	The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.	SUPT20HL1 SUPT20H SUPT20HL2	3.95e-09	3	56	3	24220028
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	NCOA3 ARID1B ACAD11 PRICKLE1 USP9X ITGA3 REV3L NCLN FER1L5 EP300	6.71e-08	638	56	10	31182584
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	USP36 ARID1B SUPT20H ACAD11 RNF31 ZNF460 ACTL6B ITGA3 REV3L LDLR EP300 TUBG1	1.70e-07	1116	56	12	31753913
Pubmed	Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification.	SUPT20HL1 SUPT20H SUPT20HL2	2.20e-07	8	56	3	21802298
Pubmed	Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.	SUPT20HL1 SUPT20H SUPT20HL2	6.46e-07	11	56	3	24051374
Pubmed	Differential expression of human γ-tubulin isotypes during neuronal development and oxidative stress points to a γ-tubulin-2 prosurvival function.	TUBG2 TUBG1	2.55e-06	2	56	2	28119396
Pubmed	Up-Regulation of Human Inducible Nitric Oxide Synthase by p300 Transcriptional Complex.	NOS2 EP300	2.55e-06	2	56	2	26751080
Pubmed	MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages.	TUBG2 TUBG1	2.55e-06	2	56	2	17442887
Pubmed	Overexpression of γ-tubulin in non-small cell lung cancer.	TUBG2 TUBG1	2.55e-06	2	56	2	22806905
Pubmed	Gene knockout analysis of two gamma-tubulin isoforms in mice.	TUBG2 TUBG1	2.55e-06	2	56	2	15893303
Pubmed	Allocation of gamma-tubulin between oocyte cortex and meiotic spindle influences asymmetric cytokinesis in the mouse oocyte.	TUBG2 TUBG1	2.55e-06	2	56	2	17287496
Pubmed	Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation.	SUPT20HL1 SUPT20H SUPT20HL2	5.15e-06	21	56	3	23747598
Pubmed	Supt20 is required for development of the axial skeleton.	SUPT20HL1 SUPT20H SUPT20HL2	5.15e-06	21	56	3	27894818
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SUPT20H UBQLN1 TUBG2 USP9X ACO1 UBQLN4 CCDC15 REV3L MLST8 PC EP300	5.42e-06	1285	56	11	35914814
Pubmed	p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.	SUPT20HL1 SUPT20H SUPT20HL2	5.96e-06	22	56	3	16751104
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	RNASE4 SUPT20H WDR36 USP9X PC TUBG1	6.10e-06	281	56	6	24163370
Pubmed	The gamma-tubulin gene family in humans.	TUBG2 TUBG1	7.63e-06	3	56	2	10903841
Pubmed	The transcriptional co-activator p/CIP (NCoA-3) is up-regulated by STAT6 and serves as a positive regulator of transcriptional activation by STAT6.	NCOA3 EP300	7.63e-06	3	56	2	15145939
Pubmed	The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription.	NCOA3 EP300	7.63e-06	3	56	2	12569362
Pubmed	Human TUBG2 gene is expressed as two splice variant mRNA and involved in cell growth.	TUBG2 TUBG1	7.63e-06	3	56	2	27015882
Pubmed	Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin.	TUBG2 TUBG1	7.63e-06	3	56	2	9566969
Pubmed	Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators.	NCOA3 EP300	7.63e-06	3	56	2	11823864
Pubmed	AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor.	NCOA3 EP300	7.63e-06	3	56	2	10866661
Pubmed	The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage.	TUBG2 TUBG1	7.63e-06	3	56	2	26021315
Pubmed	ERp57 is essential for efficient folding of glycoproteins sharing common structural domains.	ITGA3 ADAM10 LDLR	8.87e-06	25	56	3	17170699
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	GRTP1 SND1 GRK5 ITGA3 REV3L NCLN PC LDLR EP300 TUBG1	9.50e-06	1105	56	10	35748872
Pubmed	The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.	SUPT20HL1 SUPT20H SUPT20HL2	1.26e-05	28	56	3	19114550
Pubmed	Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1).	NCOA3 EP300	1.52e-05	4	56	2	16227615
Pubmed	Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma.	NCOA3 EP300	1.52e-05	4	56	2	33589584
Pubmed	Actin-related proteins.	ACTL7B ACTL6B	1.52e-05	4	56	2	10611965
Pubmed	Loss of Necdin impairs myosin activation and delays cell polarization.	TUBG2 TUBG1	1.52e-05	4	56	2	20665884
Pubmed	Cilia organize ependymal planar polarity.	TUBG2 TUBG1	1.52e-05	4	56	2	20164345
Pubmed	Piezo mechanosensory channels regulate centrosome integrity and mitotic entry.	TUBG2 TUBG1	1.52e-05	4	56	2	36574677
Pubmed	CCL19-CCR7-dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima.	NOS2 LDLR	1.52e-05	4	56	2	27668800
Pubmed	Herp enhances ER-associated protein degradation by recruiting ubiquilins.	UBQLN1 UBQLN4	1.52e-05	4	56	2	18307982
Pubmed	CBP/p300 interact with and function as transcriptional coactivators of BRCA1.	NCOA3 EP300	1.52e-05	4	56	2	10655477
Pubmed	Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes.	NCOA3 EP300	1.52e-05	4	56	2	32668201
Pubmed	A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice.	SERPINB7 NOS2	1.52e-05	4	56	2	16443768
Pubmed	Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells.	TUBG2 TUBG1	1.52e-05	4	56	2	16798874
Pubmed	A transcriptional switch mediated by cofactor methylation.	NCOA3 EP300	1.52e-05	4	56	2	11701890
Pubmed	Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase.	PRICKLE1 USP9X	1.52e-05	4	56	2	25763846
Pubmed	A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.	SUPT20HL1 SUPT20H SUPT20HL2	1.56e-05	30	56	3	18206972
Pubmed	Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.	SUPT20HL1 SUPT20H SUPT20HL2	2.08e-05	33	56	3	11564863
Pubmed	Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium.	TUBG2 TUBG1	2.54e-05	5	56	2	21285373
Pubmed	USP36 promotes tumorigenesis and drug sensitivity of glioblastoma by deubiquitinating and stabilizing ALKBH5.	USP36 USP9X	2.54e-05	5	56	2	36239338
Pubmed	Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation.	TUBG2 TUBG1	2.54e-05	5	56	2	29244804
Pubmed	Structure of a biologically active estrogen receptor-coactivator complex on DNA.	NCOA3 EP300	2.54e-05	5	56	2	25728767
Pubmed	Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia.	TUBG2 TUBG1	2.54e-05	5	56	2	31390572
Pubmed	A two-kinesin mechanism controls neurogenesis in the developing brain.	TUBG2 TUBG1	2.54e-05	5	56	2	38040957
Pubmed	Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases.	TUBG2 TUBG1	2.54e-05	5	56	2	16751367
Pubmed	Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains.	NCOA3 EP300	2.54e-05	5	56	2	12714702
Pubmed	A maternal store of macroH2A is removed from pronuclei prior to onset of somatic macroH2A expression in preimplantation embryos.	TUBG2 TUBG1	2.54e-05	5	56	2	15680357
Pubmed	Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.	NCOA3 EP300	2.54e-05	5	56	2	30418174
Pubmed	Analysis of Ellis van Creveld syndrome gene products: implications for cardiovascular development and disease.	TUBG2 TUBG1	2.54e-05	5	56	2	19251731
Pubmed	The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis.	TUBG2 TUBG1	2.54e-05	5	56	2	21529752
Pubmed	Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis.	TUBG2 TUBG1	2.54e-05	5	56	2	18729223
Pubmed	WDR62 is associated with the spindle pole and is mutated in human microcephaly.	TUBG2 TUBG1	2.54e-05	5	56	2	20890279
Pubmed	SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.	NCOA3 EP300	2.54e-05	5	56	2	9812974
Pubmed	Speriolin is a novel human and mouse sperm centrosome protein.	TUBG2 TUBG1	2.54e-05	5	56	2	20542897
Pubmed	Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies.	TUBG2 TUBG1	2.54e-05	5	56	2	25877302
Pubmed	HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.	TUBG2 TUBG1	2.54e-05	5	56	2	14767062
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	USP36 SUPT20H WDR36 WDR33 UBQLN4 NCLN RFX7 PC LDLR EP300	3.68e-05	1294	56	10	30804502
Pubmed	The CPLANE protein Fuzzy regulates ciliogenesis by suppressing actin polymerization at the base of the primary cilium via p190A RhoGAP.	TUBG2 TUBG1	3.80e-05	6	56	2	38546045
Pubmed	Temporal/spatial expression of nuclear receptor coactivators in the mouse lung.	NCOA3 EP300	3.80e-05	6	56	2	11076796
Pubmed	Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor.	TUBG2 TUBG1	3.80e-05	6	56	2	30970247
Pubmed	Expression Analyses of Cep152, a Responsible Gene Product for Autosomal Recessive Primary Microcephaly, during Mouse Brain Development.	TUBG2 TUBG1	3.80e-05	6	56	2	35259752
Pubmed	Structural and Functional Impacts of ER Coactivator Sequential Recruitment.	NCOA3 EP300	3.80e-05	6	56	2	28844863
Pubmed	RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.	UBQLN1 UBQLN4	3.80e-05	6	56	2	35247097
Pubmed	Activation of rapid oestrogen signalling in aggressive human breast cancers.	NCOA3 EP300	3.80e-05	6	56	2	23065768
Pubmed	DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.	TUBG2 TUBG1	3.80e-05	6	56	2	22842144
Pubmed	Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis.	TUBG2 TUBG1	3.80e-05	6	56	2	29229864
Pubmed	Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton.	TUBG2 TUBG1	3.80e-05	6	56	2	10840040
Pubmed	CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors.	TUBG2 TUBG1	3.80e-05	6	56	2	36334595
Pubmed	Roles of coactivators in hypoxic induction of the erythropoietin gene.	NCOA3 EP300	3.80e-05	6	56	2	20368990
Pubmed	A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.	TUBG2 TUBG1	3.80e-05	6	56	2	11237715
Pubmed	Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly.	NCOA3 EP300	3.80e-05	6	56	2	16923966
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	RNASE4 MAN2B2 AEBP1 ADAM10 LDLR	5.03e-05	248	56	5	24006456
Pubmed	HIV-1 Vpr hijacks EDD-DYRK2-DDB1DCAF1 to disrupt centrosome homeostasis.	TUBG2 TUBG1	5.32e-05	7	56	2	29724823
Pubmed	Asymmetric segregation of the double-stranded RNA binding protein Staufen2 during mammalian neural stem cell divisions promotes lineage progression.	TUBG2 TUBG1	5.32e-05	7	56	2	22902295
Pubmed	PCP auto count: a novel Fiji/ImageJ plug-in for automated quantification of planar cell polarity and cell counting.	TUBG2 TUBG1	5.32e-05	7	56	2	38827526
Pubmed	Mammalian RanBP1 regulates centrosome cohesion during mitosis.	TUBG2 TUBG1	5.32e-05	7	56	2	12840069
Pubmed	AIRE is a critical spindle-associated protein in embryonic stem cells.	TUBG2 TUBG1	5.32e-05	7	56	2	28742026
Pubmed	TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis.	TUBG2 TUBG1	5.32e-05	7	56	2	38261656
Pubmed	The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts.	TUBG2 TUBG1	5.32e-05	7	56	2	29372668
Pubmed	A Novel Mouse Model for Cilia-Associated Cardiovascular Anomalies with a High Penetrance of Total Anomalous Pulmonary Venous Return.	TUBG2 TUBG1	5.32e-05	7	56	2	30289203
Pubmed	The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine.	NCOA3 EP300	5.32e-05	7	56	2	12709428
Pubmed	Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.	UBQLN1 UBQLN4	5.32e-05	7	56	2	30664872
Pubmed	Pax6 controls centriole maturation in cortical progenitors through Odf2.	TUBG2 TUBG1	5.32e-05	7	56	2	25352170
Pubmed	A ciliopathy complex builds distal appendages to initiate ciliogenesis.	TUBG2 TUBG1	7.09e-05	8	56	2	34241634
Pubmed	The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment.	NCOA3 EP300	7.09e-05	8	56	2	12082103
Pubmed	Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.	TUBG2 TUBG1	7.09e-05	8	56	2	27727273
Pubmed	A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease.	TUBG2 TUBG1	7.09e-05	8	56	2	17908927
Pubmed	The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex.	TUBG2 TUBG1	7.09e-05	8	56	2	19112494
Pubmed	Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.	TUBG2 TUBG1	7.09e-05	8	56	2	26540106
Pubmed	Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu.	NCOA3 EP300	7.09e-05	8	56	2	14747462
Pubmed	Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.	ADAM10 NOS2	7.09e-05	8	56	2	19667218
Pubmed	Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.	UBQLN1 UBQLN4	7.09e-05	8	56	2	23459205
Pubmed	A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development.	TUBG2 TUBG1	7.09e-05	8	56	2	15958512
Pubmed	Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development.	TUBG2 TUBG1	7.09e-05	8	56	2	18239929
Pubmed	Aberrant association of promyelocytic leukemia protein-retinoic acid receptor-alpha with coactivators contributes to its ability to regulate gene expression.	NCOA3 EP300	7.09e-05	8	56	2	17475621
Interaction	TFF1 interactions	NCOA3 UBQLN1 UBQLN4 EP300	4.33e-06	41	54	4	int:TFF1
Interaction	STRAP interactions	USP36 ACO1 PC ADAM10 NOS2 LDLR EP300	7.41e-06	270	54	7	int:STRAP
Interaction	ABCF1 interactions	USP36 UBQLN1 SND1 GRK5 EIF2B2 EP300	1.58e-05	201	54	6	int:ABCF1
Interaction	SLC5A10 interactions	UBQLN1 UBQLN4	2.11e-05	3	54	2	int:SLC5A10
Interaction	CCT3 interactions	USP36 RNF31 TUBG2 EIF2B2 FBXW5 MLST8 PC NOS2 TUBG1	2.93e-05	604	54	9	int:CCT3
Interaction	TXNDC12 interactions	UBQLN1 SND1 NOS2 TUBG1 MX2	3.62e-05	140	54	5	int:TXNDC12
Interaction	RNF19A interactions	NCOA3 TUBG2 TUBG1	5.08e-05	27	54	3	int:RNF19A
Interaction	UBE2C interactions	UBQLN1 RNF31 USP9X UBQLN4	1.04e-04	91	54	4	int:UBE2C
Interaction	TCP1 interactions	USP36 RNF31 TUBG2 USP9X FBXW5 MLST8 NOS2 TUBG1	1.16e-04	561	54	8	int:TCP1
Interaction	PSMD8 interactions	UBQLN1 UBQLN4 NOS2 EP300 TUBG1	1.26e-04	182	54	5	int:PSMD8
Interaction	RIC8A interactions	UBQLN1 UBQLN4 LDLR EP300	1.27e-04	96	54	4	int:RIC8A
Interaction	ALG13 interactions	USP36 NCOA3 ARID1B WDR33 EP300	1.29e-04	183	54	5	int:ALG13
Interaction	CCT6A interactions	RNF31 TUBG2 FBXW5 MLST8 PC NOS2 EP300 TUBG1	1.29e-04	570	54	8	int:CCT6A
Cytoband	Xp22.11	SUPT20HL1 SUPT20HL2	3.02e-04	21	56	2	Xp22.11
GeneFamily	Ubiquilin family	UBQLN1 UBQLN4	3.63e-05	5	35	2	783
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	NCOA3 EP300	4.86e-04	17	35	2	486
GeneFamily	Tubulins	TUBG2 TUBG1	1.15e-03	26	35	2	778
GeneFamily	WD repeat domain containing	WDR36 WDR33 FBXW5 MLST8	1.58e-03	262	35	4	362
GeneFamily	Ubiquitin specific peptidases	USP36 USP9X	5.25e-03	56	35	2	366
Disease	complex cortical dysplasia with other brain malformations 4 (implicated_via_orthology)	TUBG2 TUBG1	3.54e-06	2	56	2	DOID:0090138 (implicated_via_orthology)
Disease	amyotrophic lateral sclerosis type 15 (implicated_via_orthology)	UBQLN1 UBQLN4	1.06e-05	3	56	2	DOID:0060206 (implicated_via_orthology)
Disease	peptic ulcer disease	SND1 UBQLN4 FUT2	3.39e-05	33	56	3	MONDO_0004247
Disease	protein FAM3B measurement	FUT2 MX2	7.38e-05	7	56	2	EFO_0021857
Disease	coffee consumption measurement, insomnia	SUPT20H PC	1.58e-04	10	56	2	EFO_0004698, EFO_0006781
Disease	frontotemporal dementia (implicated_via_orthology)	UBQLN1 UBQLN4	2.31e-04	12	56	2	DOID:9255 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	ARID1B GRK5 ACTL6B EP300	5.19e-04	195	56	4	DOID:1574 (implicated_via_orthology)
Disease	hypertension (biomarker_via_orthology)	ARID1B GRK5 NOS2 EP300	9.16e-04	227	56	4	DOID:10763 (biomarker_via_orthology)
Disease	Drug-Induced Stevens Johnson Syndrome	NOS2 EP300	1.39e-03	29	56	2	C1274933
Disease	Toxic Epidermal Necrolysis	NOS2 EP300	1.39e-03	29	56	2	C0014518
Disease	Mycoplasma-Induced Stevens-Johnson Syndrome	NOS2 EP300	1.39e-03	29	56	2	C3658301
Disease	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum	NOS2 EP300	1.39e-03	29	56	2	C3658302
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	UBQLN1 UBQLN4	1.49e-03	30	56	2	DOID:332 (implicated_via_orthology)
Disease	Stevens-Johnson Syndrome	NOS2 EP300	1.49e-03	30	56	2	C0038325
Disease	psoriasis	ACO1 REV3L FUT2 NOS2	1.80e-03	273	56	4	EFO_0000676

Protein segments in the cluster

Peptide	Gene	Start	Entry
MGFLTNYLTNRYPNL	TMEM184C	126	Q9NVA4
YLQESGVMPYLSQLG	ACO1	481	P21399
RAYAALGLPYQVNQM	EP300	466	Q09472
RADYAGGDLTNYLMQ	ACTL7B	221	Q9Y614
NLGQKENGNYIMYAR	ADAM10	406	O14672
NLNGGERLVSYPYDM	AEBP1	761	Q8IUX7
MPNGYNTDYGAERLR	ACTL6B	286	O94805
QRYQPQQDMSQEGYG	ARID1B	706	Q8NFD5
LGMGQRQQFPYGASY	ARID1B	1391	Q8NFD5
GAGVSQDYPLANMYA	ACAD11	731	Q709F0
MQQYDLQGQPYGTRN	NCLN	51	Q969V3
NAQLIRYAGYQMPDG	NOS2	261	P35228
YPYMANGSLQDRLQG	IRAK2	286	O43187
GRMSGNPDVLEYYRN	GAB3	36	Q8WWW8
GYQHIRMYDLNSNNP	MLST8	61	Q9BVC4
IGMGLSPDNRYLYVN	FBXW5	406	Q969U6
DPEDQGNLYIGYTMQ	ITGA3	241	P26006
NLRLLVYRYGMQNSG	ENPEP	781	Q07075
YGLQNPGMNRFLGLY	PRICKLE1	741	Q96MT3
LSNYRGRQYLLMPGD	CRYGD	136	P07320
RLGNQMGEYATLYAL	FUT2	71	Q10981
RLYGYRTLPGQNSDM	C9orf43	341	Q8TAL5
LSGAQAQMDQNPGYY	GRTP1	81	Q5TC63
SDNNGYQMQRRPYVS	MAN2B2	731	Q9Y2E5
SNIGGNAPSYIYRLM	EIF2B2	326	P49770
YMAPEVLNNQRYGLS	GRK5	351	P34947
PGRYDIMNLQYTEAN	GRM1	476	Q13255
SNVYLQYMRNGELPA	USP9X	1471	Q93008
LYPGNQGYSVMLQRE	SUPT20HL1	81	Q3ZLR7
YMVRAINLQPQDYNG	FER1L5	1491	A0AVI2
NQGLQMPSSRAYGLA	NCOA3	406	Q9Y6Q9
NGNYLEVLYPSMFDG	SLITRK2	431	Q9H156
NKTPQGREYGMIYLG	SND1	101	Q7KZF4
LYPGNQGYSVMLQRE	SUPT20HL2	81	P0C7V6
QGLLAAVPYQNYMEN	CCDC15	236	Q0P6D6
NDPEYQAQGLAMYLQ	RNF31	851	Q96EP0
GNVVGMYLAQNYDIP	STMP1	11	E0CX11
GLVQPSYGQDGMYQR	RNASE4	21	P34096
AQGVPRYSYLGQAMD	ZNF460	81	Q14592
RYSYLGQAMDQDGPS	ZNF460	86	Q14592
LENYGNLVSMGLYTP	ZNF383	36	Q8NA42
DGYGQQPESYLSQMA	REV3L	66	O60673
TTLRYPGYMNNDLIG	TUBG1	241	P23258
YGSDYEEMPLQNGQA	TMEM181	586	Q9P2C4
PGGYNALRRMYTDIQ	UBQLN1	266	Q9UMX0
LVVNLYPGNEGYSLM	SUPT20H	76	Q8NEM7
YPGNEGYSLMLRGKN	SUPT20H	81	Q8NEM7
YNGGINMYVLLPEND	SERPINB7	231	O75635
DAVRGLGMNNLPSNY	RFX7	1166	Q2KHR2
YRMNNHPDGPSYDRN	PKHD1L1	2586	Q86WI1
YGIYMNQDGLPGCSL	PKHD1L1	3461	Q86WI1
QDPGLGLRQIYYSMN	TRBV27	56	A0A0K0K1C4
TTLRYPGYMNNDLIG	TUBG2	241	Q9NRH3
QRDMRAIQPDAGYYN	WDR33	76	Q9C0J8
PGGYNALRRMYTDIQ	UBQLN4	276	Q9NRR5
MLLRGANAVGYTNYP	PC	641	P11498
SQNNGDPVMYGLYAV	USP36	356	Q9P275
MGHSAPLTNIRYYGQ	WDR36	376	Q8NI36
NQDGYSYPSRQMVSL	LDLR	841	P01130
RAMGPENNLYSQYEQ	MX2	81	P20592