Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	PLC activating G protein-coupled glutamate receptor activity	GRM1 GRM5	1.43e-05	2	76	2	GO:0001639
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	GRM1 GRM5	8.54e-05	4	76	2	GO:0099583
GeneOntologyMolecularFunction	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	GRM1 GRM5	1.42e-04	5	76	2	GO:0099530
GeneOntologyMolecularFunction	CoA carboxylase activity	ACACB PCCB	2.12e-04	6	76	2	GO:0016421
GeneOntologyMolecularFunction	ligase activity, forming carbon-carbon bonds	ACACB PCCB	2.97e-04	7	76	2	GO:0016885
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRM1 GRM5	5.06e-04	9	76	2	GO:0098988
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRM1 GRM5	5.06e-04	9	76	2	GO:0001640
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	HEY1 HEY2 PRKDC GRM1 TOX2 MED13 RAD23B	1.04e-03	417	76	7	GO:0061629
GeneOntologyBiologicalProcess	umbilical cord development	HEY1 HEY2	1.27e-05	2	74	2	GO:0061027
GeneOntologyBiologicalProcess	umbilical cord morphogenesis	HEY1 HEY2	1.27e-05	2	74	2	GO:0036304
GeneOntologyBiologicalProcess	phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	GRM1 GRM5	3.80e-05	3	74	2	GO:0007206
GeneOntologyBiologicalProcess	endocardial cushion to mesenchymal transition involved in heart valve formation	HEY1 HEY2	7.58e-05	4	74	2	GO:0003199
GeneOntologyBiologicalProcess	somatic recombination of T cell receptor gene segments	LIG4 PRKDC	1.26e-04	5	74	2	GO:0002681
GeneOntologyBiologicalProcess	T cell receptor V(D)J recombination	LIG4 PRKDC	1.26e-04	5	74	2	GO:0033153
GeneOntologyBiologicalProcess	somatic diversification of T cell receptor genes	LIG4 PRKDC	1.26e-04	5	74	2	GO:0002568
GeneOntologyBiologicalProcess	arterial endothelial cell differentiation	HEY1 HEY2	1.89e-04	6	74	2	GO:0060842
Domain	GPCR_3_mtglu_rcpt_5	GRM1 GRM5	1.59e-05	2	75	2	IPR000202
Domain	GluR_Homer-bdg	GRM1 GRM5	1.59e-05	2	75	2	PF10606
Domain	Med13_N	MED13L MED13	1.59e-05	2	75	2	PF11597
Domain	Metabotropic_Glu_rcpt_Homer-bd	GRM1 GRM5	1.59e-05	2	75	2	IPR019588
Domain	Mediator_Med13_N_met/fun	MED13L MED13	1.59e-05	2	75	2	IPR021643
Domain	Mediator_Med13	MED13L MED13	1.59e-05	2	75	2	IPR009401
Domain	Med13_C	MED13L MED13	1.59e-05	2	75	2	PF06333
Domain	GPCR_3_mtglu_rcpt_1	GRM1 GRM5	1.59e-05	2	75	2	IPR001256
Domain	GluR_Homer-bdg	GRM1 GRM5	1.59e-05	2	75	2	SM01229
Domain	COA_CT_N	ACACB PCCB	9.50e-05	4	75	2	IPR011762
Domain	COA_CT_C	ACACB PCCB	9.50e-05	4	75	2	IPR011763
Domain	Carboxyl_trans	ACACB PCCB	9.50e-05	4	75	2	PF01039
Domain	COA_CT_CTER	ACACB PCCB	9.50e-05	4	75	2	PS50989
Domain	Carboxyl_trans	ACACB PCCB	9.50e-05	4	75	2	IPR000022
Domain	COA_CT_NTER	ACACB PCCB	9.50e-05	4	75	2	PS50980
Domain	Sterol-sensing	NPC1 HMGCR	1.58e-04	5	75	2	PF12349
Domain	GPCR_3_mtglu_rcpt	GRM1 GRM5	4.39e-04	8	75	2	IPR000162
Domain	ORANGE	HEY1 HEY2	5.62e-04	9	75	2	SM00511
Domain	Hairy_orange	HEY1 HEY2	1.02e-03	12	75	2	PF07527
Domain	Orange_dom	HEY1 HEY2	1.02e-03	12	75	2	IPR003650
Domain	NCD3G	GRM1 GRM5	1.21e-03	13	75	2	PF07562
Domain	ORANGE	HEY1 HEY2	1.21e-03	13	75	2	PS51054
Domain	GPCR_3_9-Cys_dom	GRM1 GRM5	1.21e-03	13	75	2	IPR011500
Domain	SSD	NPC1 HMGCR	1.21e-03	13	75	2	IPR000731
Domain	SSD	NPC1 HMGCR	1.21e-03	13	75	2	PS50156
Domain	GPCR_3_CS	GRM1 GRM5	1.40e-03	14	75	2	IPR017979
Domain	-	ACACB PCCB	3.18e-03	21	75	2	3.90.226.10
Domain	GPCR_3	GRM1 GRM5	3.18e-03	21	75	2	IPR000337
Domain	ClpP/crotonase-like_dom	ACACB PCCB	3.18e-03	21	75	2	IPR029045
Domain	7tm_3	GRM1 GRM5	3.49e-03	22	75	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	GRM1 GRM5	3.49e-03	22	75	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM1 GRM5	3.49e-03	22	75	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM1 GRM5	3.49e-03	22	75	2	PS00979
Domain	G_PROTEIN_RECEP_F3_4	GRM1 GRM5	3.49e-03	22	75	2	PS50259
Domain	GPCR_3_C	GRM1 GRM5	3.49e-03	22	75	2	IPR017978
Domain	UBA	SIK1 RAD23B	6.44e-03	30	75	2	SM00165
Domain	Kringle-like	HGF PLA2R1	7.30e-03	32	75	2	IPR013806
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NPC1 PTGES2 CORO2B HEY1 ANKRD24 RIPK4 PRKDC MED13L PCCB ADAM22 MED13 MADD NR1D2 RAD23B	7.86e-07	1285	77	14	35914814
Pubmed	Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.	HEY1 LAMA2 HEY2	1.70e-06	11	77	3	21989910
Pubmed	Involvement of group I metabotropic glutamate receptors and glutamate transporters in the slow excitatory synaptic transmission in the spinal cord dorsal horn.	GRM1 GRM5	4.84e-06	2	77	2	18554818
Pubmed	Cyclic ADP ribose-dependent Ca2+ release by group I metabotropic glutamate receptors in acutely dissociated rat hippocampal neurons.	GRM1 GRM5	4.84e-06	2	77	2	22028929
Pubmed	Notch Signaling Target Genes are Directly Correlated to Esophageal Squamous Cell Carcinoma Tumorigenesis.	HEY1 HEY2	4.84e-06	2	77	2	25361534
Pubmed	Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP.	GRM1 GRM5	4.84e-06	2	77	2	9185557
Pubmed	Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse.	MED13L MED13	4.84e-06	2	77	2	29325037
Pubmed	Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex.	GRM1 GRM5	4.84e-06	2	77	2	27392515
Pubmed	Genetic inactivation of mGlu5 receptor improves motor coordination in the Grm1crv4 mouse model of SCAR13 ataxia.	GRM1 GRM5	4.84e-06	2	77	2	28982591
Pubmed	Naked axons in myodystrophic mice.	LAMA2 LARGE1	4.84e-06	2	77	2	647395
Pubmed	mGluR₁,5 activation improves network asynchrony and GABAergic synapse attenuation in the amygdala: implication for anxiety-like behavior in DBA/2 mice.	GRM1 GRM5	4.84e-06	2	77	2	22681774
Pubmed	Selective induction of metabotropic glutamate receptor 1- and metabotropic glutamate receptor 5-dependent chemical long-term potentiation at oriens/alveus interneuron synapses of mouse hippocampus.	GRM1 GRM5	4.84e-06	2	77	2	18035501
Pubmed	Determination of group I metabotropic glutamate receptor subtypes involved in the frequency of epileptiform activity in vitro using mGluR1 and mGluR5 mutant mice.	GRM1 GRM5	4.84e-06	2	77	2	12623213
Pubmed	Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation.	GRM1 GRM5	4.84e-06	2	77	2	15184389
Pubmed	mGluR1,5 activation protects cortical astrocytes and GABAergic neurons from ischemia-induced impairment.	GRM1 GRM5	4.84e-06	2	77	2	23280324
Pubmed	DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin.	LIG4 PRKDC	4.84e-06	2	77	2	18508926
Pubmed	Metabotropic glutamate receptors in the main olfactory bulb drive granule cell-mediated inhibition.	GRM1 GRM5	4.84e-06	2	77	2	17093122
Pubmed	Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.	GRM1 GRM5	4.84e-06	2	77	2	11591458
Pubmed	HERP, a new primary target of Notch regulated by ligand binding.	HEY1 HEY2	4.84e-06	2	77	2	11486044
Pubmed	Symmetric signal transduction and negative allosteric modulation of heterodimeric mGlu1/5 receptors.	GRM1 GRM5	4.84e-06	2	77	2	33279506
Pubmed	Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells.	HGF PRKDC	4.84e-06	2	77	2	29928062
Pubmed	Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes.	HEY1 HEY2	4.84e-06	2	77	2	25446183
Pubmed	In-vivo genetic ablation of metabotropic glutamate receptor type 5 slows down disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis.	GRM1 GRM5	4.84e-06	2	77	2	31102766
Pubmed	Characterization of ATPase in sarcoplasmic reticulum from two strains of dystrophic mice.	LAMA2 LARGE1	4.84e-06	2	77	2	6447833
Pubmed	mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning.	GRM1 GRM5	4.84e-06	2	77	2	35805089
Pubmed	Corticostriatal LTP requires combined mGluR1 and mGluR5 activation.	GRM1 GRM5	4.84e-06	2	77	2	12559117
Pubmed	Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression.	GRM1 GRM5	4.84e-06	2	77	2	31540330
Pubmed	Differential distribution of group I metabotropic glutamate receptors in developing human cortex.	GRM1 GRM5	4.84e-06	2	77	2	20149785
Pubmed	Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase.	LIG4 PRKDC	1.45e-05	3	77	2	15194694
Pubmed	Calcineurin inhibitor protein (CAIN) attenuates Group I metabotropic glutamate receptor endocytosis and signaling.	GRM1 GRM5	1.45e-05	3	77	2	19717561
Pubmed	Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices.	GRM1 GRM5	1.45e-05	3	77	2	12364493
Pubmed	SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5.	GRM1 GRM5	1.45e-05	3	77	2	31270711
Pubmed	HERP1 is a cell type-specific primary target of Notch.	HEY1 HEY2	1.45e-05	3	77	2	11741889
Pubmed	Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome.	GRM1 GRM5	1.45e-05	3	77	2	20410124
Pubmed	TWIST1 correlates with Notch signaling pathway to develop esophageal squamous cell carcinoma.	HEY1 HEY2	1.45e-05	3	77	2	32712748
Pubmed	Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis.	HEY1 HEY2	1.45e-05	3	77	2	10415358
Pubmed	The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors.	GRM1 GRM5	1.45e-05	3	77	2	16024054
Pubmed	Hesr, a mediator of the Notch signaling, functions in heart and vessel development.	HEY1 HEY2	1.45e-05	3	77	2	16165016
Pubmed	Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.	LIG4 PRKDC	1.45e-05	3	77	2	21245316
Pubmed	Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV.	LIG4 PRKDC	1.45e-05	3	77	2	9259561
Pubmed	Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system.	HEY1 HEY2	1.45e-05	3	77	2	10692439
Pubmed	Phosphorylated Sp1 is the regulator of DNA-PKcs and DNA ligase IV transcription of daunorubicin-resistant leukemia cell lines.	LIG4 PRKDC	1.45e-05	3	77	2	24530422
Pubmed	mGluR1 and mGluR5 Synergistically Control Cholinergic Synaptic Transmission in the Thalamic Reticular Nucleus.	GRM1 GRM5	1.45e-05	3	77	2	27466334
Pubmed	Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome.	GRM1 GRM5	1.45e-05	3	77	2	21571007
Pubmed	Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome.	GRM1 GRM5	1.45e-05	3	77	2	20534533
Pubmed	HES and HERP families: multiple effectors of the Notch signaling pathway.	HEY1 HEY2	1.45e-05	3	77	2	12548545
Pubmed	Metabotropic glutamate receptors 1 and 5 differentially regulate bulbar dopaminergic cell function.	GRM1 GRM5	1.45e-05	3	77	2	20692242
Pubmed	Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells.	HEY1 HEY2	1.45e-05	3	77	2	25799559
Pubmed	Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase.	LIG4 PRKDC	1.45e-05	3	77	2	17963495
Pubmed	Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK.	LIG4 PRKDC	1.45e-05	3	77	2	17241822
Pubmed	Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.	GRM1 GRM5	2.89e-05	4	77	2	29079293
Pubmed	DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.	LIG4 PRKDC	2.89e-05	4	77	2	17145779
Pubmed	Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.	GRM1 GRM5	2.89e-05	4	77	2	15745950
Pubmed	Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis.	COL4A2 ACACB	2.89e-05	4	77	2	34085602
Pubmed	Mutations in NOTCH1 cause aortic valve disease.	HEY1 HEY2	2.89e-05	4	77	2	16025100
Pubmed	Dystroglycan is essential for early embryonic development: disruption of Reichert's membrane in Dag1-null mice.	COL4A2 LAMA2	2.89e-05	4	77	2	9175728
Pubmed	Effects of hepatocyte growth factor-mediated activation of Dll4-Notch-Hey2 signaling pathway.	HGF HEY2	2.89e-05	4	77	2	21362320
Pubmed	The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain.	HEY1 HEY2	2.89e-05	4	77	2	12947105
Pubmed	Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs.	LIG4 PRKDC	2.89e-05	4	77	2	22529269
Pubmed	Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain.	GRM1 GRM5	2.89e-05	4	77	2	20876210
Pubmed	Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.	GRM1 GRM5	2.89e-05	4	77	2	15254091
Pubmed	Inhibitory role of Notch1 in calcific aortic valve disease.	HEY1 HEY2	2.89e-05	4	77	2	22110751
Pubmed	Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats.	HEY1 HEY2	2.89e-05	4	77	2	21290414
Pubmed	Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR.	GRM1 GRM5	2.89e-05	4	77	2	18094233
Pubmed	Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.	HEY1 HEY2	2.89e-05	4	77	2	15485867
Pubmed	Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family.	HEY1 HEY2	2.89e-05	4	77	2	10860664
Pubmed	FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment.	MED13L MED13	2.89e-05	4	77	2	29809150
Pubmed	Molecular recognition by LARGE is essential for expression of functional dystroglycan.	LAMA2 LARGE1	2.89e-05	4	77	2	15210115
Pubmed	Do transmembrane domain neuregulin 1 mutant mice exhibit a reliable sensorimotor gating deficit?	GRM1 GRM5	2.89e-05	4	77	2	21605597
Pubmed	STK11 is required for the normal program of ciliated cell differentiation in airways.	HEY1 BRSK2 SIK1	4.49e-05	31	77	3	31636950
Pubmed	Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.	LIG4 PRKDC	4.82e-05	5	77	2	19596237
Pubmed	The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina.	HEY1 HEY2	4.82e-05	5	77	2	11160397
Pubmed	Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling.	HEY1 HEY2	4.82e-05	5	77	2	25232121
Pubmed	Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.	LIG4 PRKDC	4.82e-05	5	77	2	11248063
Pubmed	DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.	LIG4 PRKDC	4.82e-05	5	77	2	15520013
Pubmed	A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes.	AKAP13 PRKDC	4.82e-05	5	77	2	29298866
Pubmed	Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors.	HEY1 HEY2	4.82e-05	5	77	2	21454491
Pubmed	Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.	HEY1 HEY2	4.82e-05	5	77	2	11095750
Pubmed	A laminin-2, dystroglycan, utrophin axis is required for compartmentalization and elongation of myelin segments.	LAMA2 LARGE1	4.82e-05	5	77	2	19321787
Pubmed	Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility.	LIG4 PRKDC	4.82e-05	5	77	2	12750264
Pubmed	Evidence of non-canonical NOTCH signaling: Delta-like 1 homolog (DLK1) directly interacts with the NOTCH1 receptor in mammals.	HEY1 HEY2	4.82e-05	5	77	2	26791579
Pubmed	HEY1 Leu94Met gene polymorphism dramatically modifies its biological functions.	HEY1 HEY2	4.82e-05	5	77	2	19802006
Pubmed	Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.	LIG4 PRKDC	4.82e-05	5	77	2	10716994
Pubmed	Overexpression of LARGE suppresses muscle regeneration via down-regulation of insulin-like growth factor 1 and aggravates muscular dystrophy in mice.	LAMA2 LARGE1	4.82e-05	5	77	2	24722207
Pubmed	Hey1 and Hey2 are differently expressed during mouse tooth development.	HEY1 HEY2	4.82e-05	5	77	2	29155305
Pubmed	HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.	HEY1 HEY2	4.82e-05	5	77	2	10588864
Pubmed	Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.	LIG4 PRKDC	4.82e-05	5	77	2	12547193
Pubmed	DNA Damage Regulates Translation through β-TRCP Targeting of CReP.	RIPK4 MED13L MED13	6.49e-05	35	77	3	26091241
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ANKRD29 CORO2B ICAM5 SPTA1 BRSK2 OGDHL GRM1 GRM5 NT5DC3 ADAM22 MADD CAP1	6.95e-05	1431	77	12	37142655
Pubmed	DNA-PK suppresses a p53-independent apoptotic response to DNA damage.	LIG4 PRKDC	7.22e-05	6	77	2	19057578
Pubmed	A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization.	GRM1 GRM5	7.22e-05	6	77	2	23911326
Pubmed	Homer: a protein that selectively binds metabotropic glutamate receptors.	GRM1 GRM5	7.22e-05	6	77	2	9069287
Pubmed	Role of HERP and a HERP-related protein in HRD1-dependent protein degradation at the endoplasmic reticulum.	HEY1 HEY2	7.22e-05	6	77	2	24366871
Pubmed	Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer.	GRM1 GRM5	7.22e-05	6	77	2	11418862
Pubmed	Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site.	HEY1 HEY2	7.22e-05	6	77	2	18239137
Pubmed	Absence of post-phosphoryl modification in dystroglycanopathy mouse models and wild-type tissues expressing non-laminin binding form of α-dystroglycan.	LAMA2 LARGE1	7.22e-05	6	77	2	22270369
Pubmed	HeyL promotes neuronal differentiation of neural progenitor cells.	HEY1 HEY2	7.22e-05	6	77	2	21259317
Pubmed	Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.	LIG4 PRKDC	7.22e-05	6	77	2	34352203
Pubmed	Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.	BRSK2 SIK1	7.22e-05	6	77	2	21985311
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	TDRD5 BNC2 AKAP13 LARGE1	7.70e-05	101	77	4	18519826
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM1 GRM5	2.33e-04	8	53	2	281
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SDK2 TRPM3 OGDHL GMPR HMGCR GLB1L2 MADD	4.32e-08	192	77	7	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	ANKRD29 WWC2 TRPM3 ICAM5 VEPH1 OGDHL SIK1	5.33e-08	198	77	7	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	metastatic_Brain-B_lymphocytes-Undetermined\|B_lymphocytes / Location, Cell class and cell subclass	SGPP1 BNC2 VEPH1 WDR82 AKAP13 KLHL8	5.23e-07	171	77	6	0d14bc9688c427ba2265984987dc3eea195b19eb
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANKRD29 WWC2 ICAM5 VEPH1 TMC5 C8orf34	5.60e-07	173	77	6	b799c06a6a5754668e789f70c0c8bc1508568575
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANKRD29 WWC2 ICAM5 VEPH1 TMC5 C8orf34	6.84e-07	179	77	6	cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 CORO2B TRPM3 VEPH1 KLHL8 ADAM22	9.11e-07	188	77	6	58ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 CORO2B TRPM3 VEPH1 KLHL8 ADAM22	9.39e-07	189	77	6	c9565e962a13a7713056ec3dbb1b67d24f9889c7
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	ANKRD29 WWC2 VEPH1 TMC5 C8orf34 LARGE1	9.99e-07	191	77	6	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ANKRD29 WWC2 VEPH1 AKAP13 TMC5 C8orf34	1.03e-06	192	77	6	29f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell	critical-Lymphoid-NK\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	COL4A2 BNC2 CORO2B VEPH1 HEY2 GMPR	1.06e-06	193	77	6	6be11fef87af04ee7a3cc223882ccd4077caded9
ToppCell	Bronchial-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BNC2 ACACB LAMA2 C1QTNF2 CSNK1G2-AS1 ANGPTL5	1.20e-06	197	77	6	dfeb4a0eb4dfba90f4a3e6ba31e0ab0e4aba5849
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	ANKRD29 WWC2 TRPM3 VEPH1 OGDHL RIPK4	1.31e-06	200	77	6	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ANKRD29 WWC2 TRPM3 ICAM5 VEPH1 SIK1	1.31e-06	200	77	6	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ANKRD29 WWC2 TRPM3 ICAM5 VEPH1 OGDHL	1.31e-06	200	77	6	8683445ad5b70748c4a1f12eb77d47623085147e
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D175\|Adult / Lineage, Cell type, age group and donor	STS HMGCR TMC5 PCCB C8orf34	6.27e-06	150	77	5	b0b6ba3686d3eb8a9b249d30be14111de3b893be
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZHX3 LIG4 SDK2 PFAS LARGE1	7.59e-06	156	77	5	7ece590fd8f29382e349dd0e5e016d2926aeb518
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 CORO2B TRPM3 SPATS2 ADAM22	9.12e-06	162	77	5	285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal-Cilia-bearing_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	NPC1 PFAS TMC5 TOX2 KIF24	9.68e-06	164	77	5	346e1530b4bf30adbcb2f7d64fdfb4cd8df69d7f
ToppCell	Basal_cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	FAT2 SDK2 SERPINB13 ALDH3A1 NT5DC3	1.03e-05	166	77	5	aea2ae12e4746149ebc6da063ef694381c098f80
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 RHCG TRPM3 SPATS2 NT5DC3	1.12e-05	169	77	5	0332f539a2f7d6dcd081a5d2f567290721f5a329
ToppCell	Influenza_Severe-B_intermediate\|Influenza_Severe / Disease group and Cell class	HLA-DOA GLRA2 SIK1 TOX2 LARGE1	1.29e-05	174	77	5	4276bdaac53aebd3084323a90ecde572d3177446
ToppCell	Control-Epithelial_alveolar-AT_1-AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANKRD29 TRPM3 VEPH1 RIPK4 DTD2	1.44e-05	178	77	5	1817bc520f3d23da8c0fa09bba50ae703a820cb1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 CORO2B TRPM3 VEPH1 SPATS2	1.52e-05	180	77	5	023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 RHCG TRPM3 SPATS2 ADAM22	1.52e-05	180	77	5	788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANKRD29 WWC2 TRPM3 VEPH1 RIPK4	1.56e-05	181	77	5	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 CORO2B TRPM3 VEPH1 KLHL8	1.56e-05	181	77	5	b7c85fbef3c06d5dc32a2a58f8d3dfabf1d79d9f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 RHCG TRPM3 VEPH1 ADAM22	1.64e-05	183	77	5	d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ANKRD29 WWC2 ICAM5 VEPH1 TMC5	1.69e-05	184	77	5	29c95b814a0b1ad8734ed68b77df29c08594e5ec
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	HGF LAMA2 KLHL8 MED13L ADAM22	1.69e-05	184	77	5	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANKRD29 WWC2 TRPM3 VEPH1 RIPK4	1.78e-05	186	77	5	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ANKRD29 WWC2 ICAM5 VEPH1 TMC5	1.87e-05	188	77	5	eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	COL4A2 HGF CORO2B LAMA2 HEY2	2.02e-05	191	77	5	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	WWC2 VEPH1 TMC5 C8orf34 LARGE1	2.02e-05	191	77	5	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 TRPM3 VEPH1 SPATS2 ADAM22	2.02e-05	191	77	5	96b78b4e819ea6052334bfcbc7abbf35897df885
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	ANKRD29 WWC2 VEPH1 TMC5 C8orf34	2.07e-05	192	77	5	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 CORO2B TRPM3 VEPH1 SPATS2	2.07e-05	192	77	5	fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCell	IPF-Epithelial-Basal\|World / Disease state, Lineage and Cell class	FAT2 SDK2 SERPINB13 RIPK4 ALDH3A1	2.07e-05	192	77	5	9b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 CORO2B TRPM3 VEPH1 SPATS2	2.07e-05	192	77	5	bae236c9f1fac77bce28d0a9cf090100d391ff77
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	BNC2 TRPM3 AKAP13 MED13L LARGE1	2.07e-05	192	77	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ICAM5 GRM1 GRM5 C8orf34 MADD	2.12e-05	193	77	5	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ICAM5 GRM1 GRM5 C8orf34 MADD	2.12e-05	193	77	5	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ICAM5 GRM1 GRM5 C8orf34 MADD	2.12e-05	193	77	5	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CORO2B TRPM3 HEY1 GLRA2 LAMA2	2.17e-05	194	77	5	8b81f039f5b25d35a4d5a41b27d4d9360ba22f15
ToppCell	distal-Epithelial-Differentiating_Basal-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAT2 SERPINB13 ICAM5 RIPK4 ALDH3A1	2.23e-05	195	77	5	3fe6e49a9161fc9e5160251e6932cb5378175a54
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ANKRD29 WWC2 VEPH1 TMC5 C8orf34	2.23e-05	195	77	5	9406866f99555198a9be311fbd65751b70f35446
ToppCell	Basal_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	FAT2 SDK2 SERPINB13 RIPK4 ALDH3A1	2.28e-05	196	77	5	3b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCell	distal-3-Epithelial-Differentiating_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAT2 SERPINB13 ICAM5 RIPK4 ALDH3A1	2.28e-05	196	77	5	77635a0f86910c4019d3370e9c8ba41de176bcf3
ToppCell	Tracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	COL4A2 ZHX3 PLA2R1 PFAS INVS	2.34e-05	197	77	5	4edf043e8f586fd375f56485841fe992a18bf853
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ANKRD29 WWC2 ICAM5 VEPH1 OGDHL	2.34e-05	197	77	5	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPC1 ICAM5 VEPH1 AKAP13 HMGCR	2.34e-05	197	77	5	bf10727fbe90b71d2ac60a11711e5f0701b3799d
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT2 SERPINB13 HEY1 RIPK4 ALDH3A1	2.40e-05	198	77	5	9718f4c013c347f1b3c785ae232dd2fb6c1fe298
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ANKRD29 TDRD5 WWC2 TRPM3 VEPH1	2.40e-05	198	77	5	5a85c286f79cde5811d2595a3397c6fb7685adee
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGPP1 HBP1 RIPK4 MAP3K1 NR1D2	2.40e-05	198	77	5	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ANKRD29 WWC2 TRPM3 ICAM5 VEPH1	2.40e-05	198	77	5	b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGPP1 HBP1 RIPK4 MAP3K1 NR1D2	2.40e-05	198	77	5	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT2 SERPINB13 HEY1 SIK1 RIPK4	2.40e-05	198	77	5	19d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT2 SERPINB13 SIK1 RIPK4 ALDH3A1	2.40e-05	198	77	5	5374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANKRD29 WWC2 VEPH1 TMC5 C8orf34	2.46e-05	199	77	5	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANKRD29 WWC2 VEPH1 TMC5 C8orf34	2.46e-05	199	77	5	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	proximal-Epithelial-Differentiating_Basal-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAT2 SERPINB13 HEY1 RIPK4 ALDH3A1	2.46e-05	199	77	5	c607346f60e5997e757e5a31cab412ab3734377b
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANKRD29 WWC2 VEPH1 TMC5 C8orf34	2.46e-05	199	77	5	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ANKRD29 WWC2 TRPM3 ICAM5 VEPH1	2.46e-05	199	77	5	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FAT2 SERPINB13 OGDHL RIPK4 ALDH3A1	2.46e-05	199	77	5	995d710d7302272e7951a5a5d766d1039089ee2b
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FAT2 SERPINB13 OGDHL RIPK4 ALDH3A1	2.46e-05	199	77	5	e9c47f565a0a7737ecff68569d668aeb707ae5a6
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ANKRD29 WWC2 TRPM3 ICAM5 VEPH1	2.46e-05	199	77	5	a270630626df614f8605abddb7dee7c4d74f6149
ToppCell	proximal-3-Epithelial-Differentiating_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAT2 SERPINB13 HEY1 RIPK4 ALDH3A1	2.46e-05	199	77	5	12e07084fc2d5d4c418df564ccc0e132b056e549
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPC1 ENOSF1 VEPH1 AKAP13 HMGCR	2.46e-05	199	77	5	2dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCell	proximal-Epithelial-Differentiating_Basal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAT2 SERPINB13 HEY1 RIPK4 ALDH3A1	2.46e-05	199	77	5	96a89a2578fad9a99c52d2cf9e26e06516a96568
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 RHCG TRPM3 OGDHL ADAM22	2.46e-05	199	77	5	3cd6383c50ce342fe5c175e2e50784d634a90e80
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PLA2R1 XPO5 HLA-DOA VEPH1 TMC5	2.52e-05	200	77	5	1b527bebbca1ef8c52449e40beb9358e37494e04
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SDK2 LAMA2 MAP3K1 ZNF121	1.33e-04	150	77	4	744050a1b665c6989f37141348af3df7579a73c9
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SDK2 ICAM5 GLRA2 ALDH3A1	1.33e-04	150	77	4	9d5bbdca19da60e1a2121ef64ec8e1375a5dbf6d
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HEY1 SIK1 TOX2 MADD	1.55e-04	156	77	4	ff39712c7a2dc1b85c598d5105789aa291dea726
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANKRD29 TRPM3 VEPH1 RIPK4	1.58e-04	157	77	4	9665a1375cfd8e9b8781c852686591226c0e0d9a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 SPATS2 NT5DC3 ADAM22	1.66e-04	159	77	4	50d951cf27a571c0c5002003c16fbc370fa17eb1
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TDRD5 LAMA2 C1QTNF2 GLB1L2	1.70e-04	160	77	4	8590281165eab6514a9f6a022b900d4c222c1044
ToppCell	Basal_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	FAT2 SDK2 SIK1 ALDH3A1	1.70e-04	160	77	4	b223cc47e68a29df4758c5ccf8f6dbffe2a6fa1d
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANKRD29 TRPM3 VEPH1 DTD2	1.74e-04	161	77	4	1e17a993126e1f2a25ee7dfbb95a74ccb2a26791
ToppCell	facs-Lung-EPCAM-3m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO2B HEY1 PFAS SPATS2	1.79e-04	162	77	4	1f1b93394b1f27cbb76b369c19b9313609edd577
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SGPP1 TRPM3 SPATS2 ADAM22	1.87e-04	164	77	4	6fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-7\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	PLA2R1 HEY1 ALDH3A1 PCCB	1.87e-04	164	77	4	81c41e1b5535b7969bcf6fa2456f828e8e8e2ff7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BNC2 SDK2 TMC5 C8orf34	2.01e-04	167	77	4	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	Fetal_29-31_weeks-Epithelial-basal_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FAT2 SERPINB13 HEY2 RIPK4	2.05e-04	168	77	4	6521bead9789d626b86cbd08692c621c5a5aef33
ToppCell	Basal_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	FAT2 SDK2 SERPINB13 ALDH3A1	2.05e-04	168	77	4	48089fa2d4a0f31a72405717119b767a92571f01
ToppCell	AT1-AT2_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	COL4A2 ANKRD29 WWC2 SIK1	2.10e-04	169	77	4	815474855a70498a74e52f6583113c63b7267a0c
ToppCell	Fetal_29-31_weeks-Epithelial-basal_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FAT2 SERPINB13 HEY2 RIPK4	2.10e-04	169	77	4	c3ee781735a9288ce1822b230d39bb91c1415589
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FAT2 TRPM3 VEPH1 ADAM22	2.15e-04	170	77	4	928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCell	Influenza_Severe-B_intermediate\|World / Disease group and Cell class	HLA-DOA GLRA2 TOX2 LARGE1	2.20e-04	171	77	4	4d33e1dc1efc423dbdd5f4cca6d6440a68add8d0
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FAT2 OGDHL RIPK4 ALDH3A1	2.25e-04	172	77	4	e9095c3dac66cf93d31f5f88364b565abacb1e2d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TDRD5 PLA2R1 LAMA2 NT5DC3	2.30e-04	173	77	4	8ac2e9d39c0f76e674f8bd59d1da246bab4867c8
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT2 SERPINB13 ALDH3A1 GRM1	2.35e-04	174	77	4	207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD29 GLRA2 GMPR C8orf34	2.40e-04	175	77	4	e78bf0c33a741bb97e987e41ac33da9e623a08ec
ToppCell	Pericytes-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	COL4A2 BRSK2 HEY2 C1QTNF2	2.40e-04	175	77	4	ddf721023a7afc8085c5de17aa254a6575444c0f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RHCG ANKRD29 GMPR ADAM22	2.40e-04	175	77	4	1d8da48236549c01381f777ce5b2937f9f86acc2
ToppCell	AT1_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	COL4A2 ANKRD29 TDRD5 STS	2.45e-04	176	77	4	458720776b0151cd55acc352d509599cb62f0ca8
ToppCell	COVID-19-kidney-CD-IC-A\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RHCG OGDHL GMPR ADAM22	2.45e-04	176	77	4	45028197364c64e93e3ffe86aff773d47a477d49
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRM5 C8orf34 MAP3K1 LARGE1	2.45e-04	176	77	4	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FAT2 SERPINB13 RIPK4 ALDH3A1	2.50e-04	177	77	4	ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3-4_RORB_FOLH1B\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD29 PLA2R1 LAMA2 TOX2	2.56e-04	178	77	4	22955b82917206aeed49dc0ac4630ccd9e51c4a5
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A2 ZHX3 PLA2R1 CORO2B	2.61e-04	179	77	4	025d414ec88d5680d99c8173e70ee3bb0b694f74
Drug	H-89, Dihydrochloride; Up 200; 0.5uM; PC3; HT_HG-U133A	ZHX3 WWC2 ACACB AKAP13 TMC5 LARGE1 RAD23B	4.25e-06	194	77	7	6921_UP
Drug	xanthanoic acid	GRM1 GRM5	1.13e-05	2	77	2	CID000065736
Drug	rhodizonic acid	RHCG HGF SPTA1 CNDP2 LAMA2 INVS	2.43e-05	170	77	6	CID000067050
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	NPC1 COL4A2 HEY1 OGDHL GMPR RIPK4	3.14e-05	178	77	6	5693_UP
Drug	fenobam	GRM1 GRM5	3.38e-05	3	77	2	CID000162834
Drug	aminocyclopentane	PFAS GRM1 GRM5	3.47e-05	19	77	3	CID000002906
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	NPC1 CORO2B HEY1 GMPR AKAP13 RIPK4	3.56e-05	182	77	6	5017_UP
Drug	2-propylpentanoic acid; Down 200; 1000uM; HL60; HT_HG-U133A	COL4A2 ENOSF1 HGF STS ERAP1 SIK1	4.14e-05	187	77	6	2669_DN
Drug	rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA	ENOSF1 HGF ERAP1 SIK1 AKAP13 HBP1	4.94e-05	193	77	6	921_UP
Drug	ICI182,780; Up 200; 1uM; PC3; HT_HG-U133A	WWC2 ACACB SIK1 MED13L NR1D2 RAD23B	5.23e-05	195	77	6	6918_UP
Drug	radicicol; Down 200; 0.1uM; HL60; HG-U133A	TRPM3 GLRA2 AKAP13 NR1D2 POLR3C RAD23B	5.23e-05	195	77	6	544_DN
Drug	Levonordefrin [829-74-3]; Down 200; 21.8uM; HL60; HT_HG-U133A	HGF PTGES2 GRM1 TMC5 MAP3K1 NR1D2	5.38e-05	196	77	6	2710_DN
Drug	Benzthiazide [91-33-8]; Up 200; 9.2uM; PC3; HT_HG-U133A	STS ACACB ERAP1 LAMA2 GLB1L2 RAD23B	5.38e-05	196	77	6	6607_UP
Drug	LY 294002; Down 200; 10uM; HL60; HT_HG-U133A	COL4A2 BNC2 LIG4 STS SIK1 GRM1	5.38e-05	196	77	6	2687_DN
Drug	Allantoin [97-59-6]; Up 200; 25.2uM; PC3; HT_HG-U133A	SGPP1 ZHX3 PTGES2 ERAP1 GMPR HMGCR	5.53e-05	197	77	6	1800_UP
Drug	Todralazine hydrochloride [3778-76-5]; Up 200; 14.8uM; MCF7; HT_HG-U133A	WWC2 HEY1 ERAP1 AKAP13 GRM1 TMC5	5.53e-05	197	77	6	1677_UP
Drug	Talampicillin hydrochloride [39878-70-1]; Up 200; 7.8uM; HL60; HT_HG-U133A	COL4A2 ZHX3 ACACB LAMA2 SIK1 MAP3K1	5.53e-05	197	77	6	2954_UP
Drug	genistein; Down 200; 10uM; PC3; HG-U133A	ENOSF1 ZHX3 HEY1 SPATS2 MED13L RAD23B	5.53e-05	197	77	6	703_DN
Drug	Aminohippuric acid [61-78-9]; Down 200; 20.6uM; PC3; HT_HG-U133A	COL4A2 STS ERAP1 AKAP13 CTSO RAD23B	5.69e-05	198	77	6	6294_DN
Drug	Biotin [58-85-5]; Up 200; 16.4uM; MCF7; HT_HG-U133A	HGF ACACB TRPM3 HEY2 TMC5 ADAM22	5.69e-05	198	77	6	3289_UP
Drug	Procarbazine hydrochloride [366-70-1]; Up 200; 15.6uM; MCF7; HT_HG-U133A	HGF ERAP1 HEY2 GRM1 ADAM22 INVS	5.69e-05	198	77	6	3533_UP
Drug	NF-21	HGF PTGES2	6.74e-05	4	77	2	CID000087296
Drug	Cbpg	GRM1 GRM5	6.74e-05	4	77	2	CID005311040
Drug	D-GDH	PTGES2 GLRA2	6.74e-05	4	77	2	CID000128097
Drug	1-chloro-1,2,2-trifluorocyclobutane	GLRA2 GRM1 GRM5	7.15e-05	24	77	3	CID000079091
Drug	AC1L1D63	PTGES2 GRM1 GRM5	8.11e-05	25	77	3	CID000002209
Drug	JP8 aviation fuel	HGF FAT2 STS HMGCR PRKDC MAP3K1 MADD CAP1	8.54e-05	419	77	8	ctd:C098607
Drug	L-689,560	GLRA2 GRM1 GRM5	1.03e-04	27	77	3	CID000121918
Drug	hexadecanol	NPC1 HGF HMGCR ALDH3A1	1.04e-04	72	77	4	CID000002682
Drug	CB3717	HGF GLRA2 DHFR2 CNDP2	1.10e-04	73	77	4	CID000001405
Drug	corticosterone hemisuccinate	GRM1 GRM5	1.12e-04	5	77	2	CID000159273
Drug	DMeOB	GRM1 GRM5	1.12e-04	5	77	2	CID002061047
Drug	AC1LCUX7	GRM1 GRM5	1.12e-04	5	77	2	CID000656420
Drug	Acamprosate	GRM1 GRM5	1.12e-04	5	77	2	DB00659
Drug	LY393675	GRM1 GRM5	1.12e-04	5	77	2	CID005311262
Drug	Cao C	PTGES2 GLRA2	1.12e-04	5	77	2	CID000166617
Drug	tyrphostin B52	GRM1 GRM5	1.12e-04	5	77	2	CID005328773
Drug	triethylammonium chloride	GRM1 GRM5	1.12e-04	5	77	2	CID000011130
Drug	AC1L1E5T	CNDP2 SIK1 GRM1 GRM5	1.16e-04	74	77	4	CID000002653
Drug	AC1NUW3V	GLRA2 GRM1 GRM5	1.28e-04	29	77	3	CID005462126
Drug	GYKI 53655	CNDP2 GRM1 GRM5	1.41e-04	30	77	3	CID000126757
Drug	NPC 12626	GLRA2 GRM1 GRM5	1.56e-04	31	77	3	CID000108099
Drug	LY235959	GLRA2 GRM1 GRM5	1.56e-04	31	77	3	CID000131938
Drug	eliprodil	GLRA2 GRM1 GRM5	1.56e-04	31	77	3	CID000060703
Drug	NBMPR-P	STS DHFR2	1.68e-04	6	77	2	CID006335125
Drug	AC1MBZ3L	GRM1 GRM5	1.68e-04	6	77	2	CID002733524
Drug	MTEP	GRM1 GRM5	1.68e-04	6	77	2	CID009794218
Drug	SIB-1757	GRM1 GRM5	1.68e-04	6	77	2	CID006304902
Drug	forskolin; Up 200; 50uM; MCF7; HT_HG-U133A_EA	NPC1 ACACB SIK1 HBP1 MAP3K1	1.94e-04	157	77	5	913_UP
Drug	Thioridazine hydrochloride [130-61-0]; Up 200; 9.8uM; MCF7; HT_HG-U133A	NPC1 SIK1 HBP1 HMGCR MAP3K1	2.24e-04	162	77	5	1486_UP
Drug	kainite	CNDP2 AKAP13 GRM1	2.25e-04	35	77	3	CID000164810
Drug	Niclosamide [50-65-7]; Up 200; 12.2uM; MCF7; HT_HG-U133A	NPC1 HBP1 HMGCR MED13L MAP3K1	2.31e-04	163	77	5	1498_UP
Drug	azetidine-2,4-dicarboxylic acid	GRM1 GRM5	2.34e-04	7	77	2	CID000005370
Drug	MCCG-I	GRM1 GRM5	2.34e-04	7	77	2	CID005311457
Drug	CDPPB	GRM1 GRM5	2.34e-04	7	77	2	CID011245456
Drug	I CR	HGF STS PRKDC	2.45e-04	36	77	3	CID011840956
Drug	C6H12NO5P	GLRA2 GRM1 GRM5	2.45e-04	36	77	3	CID000104962
Drug	Bisacodyl [603-50-9]; Up 200; 11uM; MCF7; HT_HG-U133A	SGPP1 HEY1 HBP1 MED13L ADAM22	2.88e-04	171	77	5	3297_UP
Drug	HA-966	GLRA2 GRM1 GRM5	3.11e-04	39	77	3	CID000001232
Drug	DETC-MeSO	ALDH3A1 GRM1 GRM5	3.11e-04	39	77	3	CID003035711
Drug	trimethylamine-cyanoborane	DHFR2 HMGCR	3.12e-04	8	77	2	CID006328234
Drug	cis-MCG-I	GRM1 GRM5	3.12e-04	8	77	2	CID003035584
Drug	6-nitrobenzo(a)pyrene	STS GMPR	3.12e-04	8	77	2	CID000044374
Drug	Mefloquine hydrochloride [51773-92-3]; Up 200; 9.6uM; PC3; HT_HG-U133A	NPC1 HEY1 ERAP1 HBP1 LARGE1	3.46e-04	178	77	5	2048_UP
Drug	Biotin	ACACB PCCB	4.00e-04	9	77	2	DB00121
Drug	delta 7-PGA1	PTGES2 PRKDC	4.00e-04	9	77	2	CID006438550
Drug	mM PEP	GRM1 GRM5	4.00e-04	9	77	2	CID005311462
Drug	nortropanol	STS GLRA2	4.00e-04	9	77	2	CID000068147
Drug	AC1N21PP	GRM1 GRM5	4.00e-04	9	77	2	CID004014619
Drug	septacidin	NPC1 PRKDC	4.00e-04	9	77	2	CID000096278
Drug	1,3-cyclopentanedicarboxylic acid	GRM1 GRM5	4.00e-04	9	77	2	CID000107216
Drug	trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A	NPC1 ZHX3 HEY1 OGDHL GMPR	4.13e-04	185	77	5	5935_UP
Drug	cyclothiazide	GLRA2 CNDP2 GRM1 GRM5	4.15e-04	103	77	4	CID000002910
Drug	LY 294002; Up 200; 10uM; PC3; HT_HG-U133A	ERAP1 LAMA2 AKAP13 HBP1 NR1D2	4.23e-04	186	77	5	4463_UP
Drug	Zardaverine [101975-10-4]; Down 200; 15uM; HL60; HT_HG-U133A	HGF PTGES2 ERAP1 PFAS NR1D2	4.23e-04	186	77	5	2926_DN
Drug	GBR 12909 dihydrochloride [67469-78-7]; Up 200; 7.6uM; MCF7; HT_HG-U133A	HGF GLRA2 GMPR RIPK4 GRM1	4.34e-04	187	77	5	3240_UP
Drug	17-AAG; Up 200; 1uM; HL60; HT_HG-U133A	COL4A2 STS ACACB ERAP1 ADAM22	4.34e-04	187	77	5	1147_UP
Drug	Adenosine 5'-monophosphate monohydrate [18422-05-4]; Down 200; 11uM; HL60; HG-U133A	HGF PFAS RBM28 MED13 MADD	4.44e-04	188	77	5	1622_DN
Drug	celecoxib; Up 200; 10uM; MCF7; HT_HG-U133A_EA	STS ERAP1 AKAP13 MED13L GRM1	4.55e-04	189	77	5	922_UP
Drug	Fenbendazole [43210-67-9]; Up 200; 13.4uM; MCF7; HT_HG-U133A	COL4A2 ACACB AKAP13 ALDH3A1 GRM1	4.66e-04	190	77	5	3888_UP
Drug	7-chlorokynurenic acid	GLRA2 GRM1 GRM5	4.76e-04	45	77	3	CID000001884
Drug	Metyrapone [54-36-4]; Up 200; 17.6uM; MCF7; HT_HG-U133A	CORO2B STS GLRA2 GMPR ADAM22	4.78e-04	191	77	5	5667_UP
Drug	Fluticasone propionate [80474-14-2]; Up 200; 8uM; MCF7; HT_HG-U133A	BNC2 PLA2R1 STS SIK1 ADAM22	4.89e-04	192	77	5	4129_UP
Drug	Cinoxacin [28657-80-9]; Down 200; 15.2uM; HL60; HT_HG-U133A	HGF LIG4 STS TMC5 MAP3K1	4.89e-04	192	77	5	2722_DN
Drug	panobinostat	SGPP1 BNC2 ERAP1 VEPH1 LAMA2 HEY2 SIK1 RIPK4 MED13L TMC5 TOX2 C8orf34 ADAM22	4.94e-04	1333	77	13	ctd:C496932
Drug	N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo(d)thiazol-2-yl)acetamide	HGF PRKDC	4.99e-04	10	77	2	ctd:C558744
Drug	3,5-dihydroxyphenylglycine	GRM1 GRM5	4.99e-04	10	77	2	ctd:C079215
Drug	NS-105	GRM1 GRM5	4.99e-04	10	77	2	CID000198695
Drug	Vitamin K2 [11032-49-8]; Up 200; 9uM; MCF7; HT_HG-U133A	STS HEY2 ALDH3A1 ADAM22 RAD23B	5.01e-04	193	77	5	3880_UP
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A	COL4A2 HGF PTGES2 ERAP1 NR1D2	5.01e-04	193	77	5	2904_DN
Drug	Podophyllotoxin [518-28-5]; Down 200; 9.6uM; HL60; HT_HG-U133A	HGF PTGES2 PFAS GRM1 NR1D2	5.01e-04	193	77	5	2540_DN
Drug	Novobiocin sodium salt [1476-53-5]; Up 200; 6.4uM; PC3; HT_HG-U133A	CORO2B ERAP1 ICAM5 BRSK2 LARGE1	5.01e-04	193	77	5	4569_UP
Drug	prochlorperazine dimaleate salt; Up 200; 10uM; MCF7; HG-U133A	NPC1 AKAP13 HBP1 MED13L MAP3K1	5.01e-04	193	77	5	455_UP
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A	COL4A2 HGF STS TMC5 NR1D2	5.01e-04	193	77	5	2721_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A	COL4A2 STS ERAP1 ICAM5 MAP3K1	5.13e-04	194	77	5	2474_DN
Drug	Finasteride [98319-26-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A	COL4A2 STS LAMA2 GRM1 CTSO	5.13e-04	194	77	5	3641_UP
Drug	Epivincamine [6835-99-0]; Up 200; 11.2uM; HL60; HG-U133A	ICAM5 GLRA2 LAMA2 SPATS2 GRM1	5.13e-04	194	77	5	1783_UP
Drug	Flutamide [13311-84-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A	WWC2 AKAP13 MED13L NR1D2 RAD23B	5.13e-04	194	77	5	4361_DN
Drug	Methionine sulfoximine (L) [15985-39-4]; Down 200; 22.2uM; HL60; HT_HG-U133A	SGPP1 COL4A2 PTGES2 ACACB NT5DC3	5.25e-04	195	77	5	2470_DN
Drug	Dilazep dihydrochloride [20153-98-4]; Up 200; 6uM; HL60; HT_HG-U133A	SERPINB13 STS ERAP1 TMC5 CTSO	5.25e-04	195	77	5	2333_UP
Disease	Attention deficit hyperactivity disorder	STS GRM1 GRM5 MED13	4.15e-07	24	76	4	C1263846
Disease	Attention Deficit Disorder	STS GRM1 GRM5	2.44e-05	22	76	3	C0041671
Disease	Minimal Brain Dysfunction	STS GRM1 GRM5	2.44e-05	22	76	3	C1321905
Disease	Cerebral Astrocytoma	HGF HEY1 HEY2	3.63e-05	25	76	3	C0750935
Disease	Intracranial Astrocytoma	HGF HEY1 HEY2	3.63e-05	25	76	3	C0750936
Disease	Pilocytic Astrocytoma	HGF HEY1 HEY2	3.63e-05	25	76	3	C0334583
Disease	Astrocytoma	HGF HEY1 HEY2	3.63e-05	25	76	3	C0004114
Disease	Juvenile Pilocytic Astrocytoma	HGF HEY1 HEY2	3.63e-05	25	76	3	C0280783
Disease	Diffuse Astrocytoma	HGF HEY1 HEY2	3.63e-05	25	76	3	C0280785
Disease	Grade I Astrocytoma	HGF HEY1 HEY2	3.63e-05	25	76	3	C1704230
Disease	Subependymal Giant Cell Astrocytoma	HGF HEY1 HEY2	3.63e-05	25	76	3	C0205768
Disease	Mixed oligoastrocytoma	HGF HEY1 HEY2	3.63e-05	25	76	3	C0547065
Disease	Childhood Cerebral Astrocytoma	HGF HEY1 HEY2	3.63e-05	25	76	3	C0338070
Disease	Gemistocytic astrocytoma	HGF HEY1 HEY2	4.09e-05	26	76	3	C0334581
Disease	Protoplasmic astrocytoma	HGF HEY1 HEY2	4.09e-05	26	76	3	C0334580
Disease	Fibrillary Astrocytoma	HGF HEY1 HEY2	4.09e-05	26	76	3	C0334582
Disease	Anaplastic astrocytoma	HGF HEY1 HEY2	4.59e-05	27	76	3	C0334579
Disease	autosomal recessive limb-girdle muscular dystrophy (is_implicated_in)	LAMA2 HMGCR	6.51e-05	5	76	2	DOID:0110274 (is_implicated_in)
Disease	severe pre-eclampsia (is_marker_for)	COL4A2 ERAP1	1.81e-04	8	76	2	DOID:13129 (is_marker_for)
Disease	Autistic behavior	TRPM3 MED13	1.81e-04	8	76	2	C0856975
Disease	hemangiopericytoma (is_marker_for)	HEY1 HEY2	2.33e-04	9	76	2	DOID:264 (is_marker_for)
Disease	sleep duration	PTGES2 SPTA1 LAMA2 TMC5 GRM5 PCCB	3.47e-04	362	76	6	EFO_0005271
Disease	Congenital muscular dystrophy	LAMA2 LARGE1	4.25e-04	12	76	2	cv:C0699743
Disease	very low density lipoprotein cholesterol measurement	ZHX3 ACACB HMGCR KLHL8 PCCB	5.67e-04	260	76	5	EFO_0008317
Disease	tetralogy of Fallot (implicated_via_orthology)	HEY2 INVS	5.84e-04	14	76	2	DOID:6419 (implicated_via_orthology)
Disease	Diabetic Asymmetric Polyneuropathy	HGF GRM5	5.84e-04	14	76	2	C0393835
Disease	Diabetic Neuralgia	HGF GRM5	5.84e-04	14	76	2	C0751074
Disease	Diabetic Neuropathies	HGF GRM5	5.84e-04	14	76	2	C0011882
Disease	Asymmetric Diabetic Proximal Motor Neuropathy	HGF GRM5	5.84e-04	14	76	2	C0271674
Disease	Symmetric Diabetic Proximal Motor Neuropathy	HGF GRM5	5.84e-04	14	76	2	C0271673
Disease	Diabetic Mononeuropathy	HGF GRM5	5.84e-04	14	76	2	C0271678
Disease	Diabetic Autonomic Neuropathy	HGF GRM5	5.84e-04	14	76	2	C0271686
Disease	Diabetic Amyotrophy	HGF GRM5	5.84e-04	14	76	2	C0271685
Disease	Diabetic Polyneuropathies	HGF GRM5	5.84e-04	14	76	2	C0271680
Disease	cortical surface area measurement	HGF ZHX3 BNC2 BRSK2 LAMA2 HEY2 HMGCR MED13L CTSO MAP3K1 RAD23B	6.38e-04	1345	76	11	EFO_0010736
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	PTGES2 ACACB HMGCR KLHL8 PCCB	7.18e-04	274	76	5	EFO_0004530, EFO_0004612
Disease	myopia (is_implicated_in)	HGF LAMA2	7.67e-04	16	76	2	DOID:11830 (is_implicated_in)
Disease	Intellectual Disability	TRPM3 BRSK2 RBM28 MED13L MED13 LARGE1	1.04e-03	447	76	6	C3714756
Disease	Severe Combined Immunodeficiency	LIG4 PRKDC	1.21e-03	20	76	2	C0085110
Disease	central corneal thickness	AKAP13 ALDH3A1 KLHL8 NT5DC3 PCCB	1.23e-03	309	76	5	EFO_0005213
Disease	hair color	BNC2 SIK1 MED13L GRM5 MAP3K1	1.26e-03	311	76	5	EFO_0003924
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	ACACB HMGCR KLHL8	1.44e-03	86	76	3	EFO_0008595, EFO_0020945
Disease	initial pursuit acceleration	PFAS MED13 MAP3K1	1.49e-03	87	76	3	EFO_0008434
Disease	Epilepsy, Benign Psychomotor, Childhood	GRM1 GRM5	1.60e-03	23	76	2	C0393672
Disease	Epilepsy, Lateral Temporal	GRM1 GRM5	1.60e-03	23	76	2	C0393682
Disease	Uncinate Epilepsy	GRM1 GRM5	1.60e-03	23	76	2	C0014558
Disease	Epilepsy, Temporal Lobe	GRM1 GRM5	1.60e-03	23	76	2	C0014556
Disease	Carcinoma, Pancreatic Ductal	HEY1 HEY2	1.74e-03	24	76	2	C0887833
Disease	Ureteral obstruction	HEY1 HEY2	1.74e-03	24	76	2	C0041956
Disease	digestive system infectious disorder	NPC1 ANKRD29	2.04e-03	26	76	2	MONDO_0043424
Disease	myocardial infarction	COL4A2 ZHX3 VEPH1 HMGCR PCCB	2.12e-03	350	76	5	EFO_0000612
Disease	Nephrotic Syndrome	COL4A2 XPO5	2.20e-03	27	76	2	C0027726
Disease	cortical thickness	COL4A2 ZHX3 BNC2 XPO5 LAMA2 KLHL8 PCCB MAP3K1 RAD23B	2.21e-03	1113	76	9	EFO_0004840
Disease	free cholesterol measurement, very low density lipoprotein cholesterol measurement	ZHX3 ACACB HMGCR PCCB	2.33e-03	215	76	4	EFO_0008317, EFO_0008591
Disease	non-high density lipoprotein cholesterol measurement	NPC1 COL4A2 ZHX3 BNC2 SPTA1 HMGCR PCCB	2.41e-03	713	76	7	EFO_0005689
Disease	very low density lipoprotein cholesterol measurement, lipid measurement	ZHX3 ACACB HMGCR PCCB	2.54e-03	220	76	4	EFO_0004529, EFO_0008317

Protein segments in the cluster

Peptide	Gene	Start	Entry
MGKGGDAASHLFTAS	TDRD5	751	Q8NAT2
TEDSHLNGYGRGMAE	BNC2	941	Q6ZN30
GNSGMGSYHGKKSFE	ALDH3A1	406	P30838
QSLDGFYSHGMGAEG	AKAP13	1506	Q12802
NIHKMDGYSCDGVQG	ADAM22	526	Q9P0K1
ASSGVGHSLKNYMEE	C8orf34	471	Q49A92
DGGTALLAASQYGHM	ANKRD29	111	Q8N6D5
DMHRGYADSPSKAGA	CAP1	26	Q01518
IGYSFLMHTAAGDEG	COL4A2	1621	P08572
FKMHLGRYSGNAGDA	ANGPTL5	271	Q86XS5
SNVMSADGAGYNALH	ANKRD24	106	Q8TF21
SGGIAEAGSGHMNYI	RAD23B	346	P54727
VHGNMKGQSLGYAFA	RBM28	531	Q9NW13
EDGGHVEAGSSYAEM	ACACB	911	O00763
TGGKGYFDAHALAMD	HEY2	106	Q9UBP5
GRNMQYHSNSGKEEG	DTD2	101	Q96FN9
GNHSKTYSMEEGTGD	LARGE1	96	O95461
AVHTEGNYGESGMEA	GRM5	216	P41594
SLEQSYAHAGLGGMA	MADD	1021	Q8WXG6
QFHKMAGRGTYGSEE	MED13L	1361	Q71F56
AMAGSIGGYNAHAAN	HMGCR	741	P04035
AYGATGAGKTHTMLG	KIF18A	111	Q8NI77
MTSTGKDGGAQHAQY	BRSK2	1	Q8IWQ3
KILMNEGGHYNASSG	C1QTNF2	171	Q9BXJ5
GGHGADAMHTDPDYS	ENOSF1	21	Q7L5Y1
QEHYMKGSDGAPDTG	ERAP1	546	Q9NZ08
EGNKDGVFSMNSYSG	FAT2	1696	Q9NYQ8
VAGAMGSHGGEYECA	ICAM5	801	Q9UMF0
HVYAVGGNDGMASLS	KLHL8	461	Q9P2G9
AADEGSGDVKYHLGM	OGDHL	326	Q9ULD0
AFHTMLTKGVGSDDG	VEPH1	451	Q14D04
GQLGTHAEYASGLMS	KIF24	1036	Q5T7B8
GHIKVSYDLGSGMAS	LAMA2	2396	P24043
GESYRGLMDHTESGK	HGF	216	P14210
GHDYTSSKGQNMVCG	NPC1	896	O15118
GGAYDVMSSKHLCGD	PCCB	436	P05166
DTHMLYLAGKGDGNI	CORO2B	281	Q9UQ03
QEAGATKADHMGSYG	HLA-DOA	21	P06340
TGTHGDAGDFAMIAY	LIG4	116	P49917
NFSGYGMGHCLQVKD	GLRA2	371	P23416
VGGSSVYKEAMNHLG	DHFR2	116	Q86XF0
EEDLQMGIHKGYGSD	HBP1	246	O60381
TAGGKGYFDAHALAM	HEY1	106	Q9Y5J3
VDAGSSINLYMFHGG	GLB1L2	306	Q8IW92
SDTAMNKHAGGVAEY	GMPR	271	P36959
HTEGNYGESGMDAFK	GRM1	231	Q13255
SGNSAKSGALGHSEM	SDK2	1966	Q58EX2
NMADKYGGTALHAAA	INVS	351	Q9Y283
GKKYSVDDLHSMGAG	NR1D2	466	Q14995
MAGGSVAHLLSKYGA	MAP3K1	1326	Q13233
ESAGNMKGTADNGYL	NKPD1	281	Q17RQ9
LEQMSDFYGKSSHGN	NT5DC3	196	Q86UY8
GAGIACGSHVTYNMG	SGPP1	326	Q9BX95
GKSQHGVYGDAVEEM	STS	301	P08842
AKNGEMFDYLTSNGH	SIK1B	106	A0A0B4J2F2
AKNGEMFDYLTSNGH	SIK1	106	P57059
GAVEGAVAKYMGAAA	PTGES2	271	Q9H7Z7
QQFHKMAGRGSYGTD	MED13	1311	Q9UHV7
HRGAGKEAMTSDGYT	RIPK4	706	P57078
GYGFVCEKMQDTSGH	PLA2R1	1091	Q13018
GVDGYAHVKMGSNVC	CTSO	296	P43234
YANGGKAAMDSRASD	CSNK1G2-AS1	66	Q8NCQ2
DLHSGVYGGSVHEAM	CNDP2	226	Q96KP4
KGGMNGYHVNGAIND	SPATS2	126	Q86XZ4
MSGGQSGYELSEAKA	WWC2	206	Q6AWC2
GVVMHTFGGYANSKA	WDR82	226	Q6UXN9
SGDSGGGMYVINLHK	POLR3C	326	Q9BUI4
GDAFSEHKADYSGMS	SERPINB13	306	Q9UIV8
EHKADYSGMSSGSGL	SERPINB13	311	Q9UIV8
TIEFQGGGHSNKAMY	TRPM3	141	Q9HCF6
FSGGIGSMEADHISK	PFAS	426	O15067
MHYILSAAQTADGGG	XPO5	296	Q9HAV4
QKTGQEMIEGGHYAS	SPTA1	641	P02549
LAASENNGGEGIHYM	PRKDC	2171	P78527
KDAGGSMTIHTFGAY	RHCG	176	Q9UBD6
LNAHMGTENTGDTYD	ZNF121	26	P58317
QKFDGDSAYVGMSDG	TOX2	41	Q96NM4
AENGHDYGSSETPKM	TMC5	246	Q6UXY8
TGELTAVHKGMGDTY	ZHX3	906	Q9H4I2