Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	interleukin-15 receptor activity	IL2RB IL2RG	2.66e-05	3	60	2	GO:0042010
GeneOntologyMolecularFunction	interleukin-2 binding	IL2RB IL2RG	2.66e-05	3	60	2	GO:0019976
GeneOntologyMolecularFunction	interleukin-2 receptor activity	IL2RB IL2RG	2.66e-05	3	60	2	GO:0004911
MousePheno	abnormal retina vasculature morphology	AOC1 DST ZNF280C ZFC3H1 ZNF626 NUDT13 CALHM4 ARF3	2.98e-05	390	45	8	MP:0002792
MousePheno	abnormal eye vasculature morphology	AOC1 DST ZNF280C ZFC3H1 ZNF626 NUDT13 CALHM4 ARF3	4.64e-05	415	45	8	MP:0031346
Domain	KRAB	ZNF93 ZNF845 ZNF486 ZNF556 ZNF257 ZNF253 ZNF737 ZNF90 ZNF626	2.28e-06	358	61	9	PS50805
Domain	KRAB	ZNF93 ZNF845 ZNF486 ZNF556 ZNF257 ZNF253 ZNF737 ZNF90 ZNF626	2.28e-06	358	61	9	PF01352
Domain	KRAB	ZNF93 ZNF845 ZNF486 ZNF556 ZNF257 ZNF253 ZNF737 ZNF90 ZNF626	2.92e-06	369	61	9	SM00349
Domain	KRAB	ZNF93 ZNF845 ZNF486 ZNF556 ZNF257 ZNF253 ZNF737 ZNF90 ZNF626	2.98e-06	370	61	9	IPR001909
Domain	zf-C2H2_6	ZNF93 ZNF845 ZNF486 ZNF556 ZNF253 ZNF737 ZNF90 ZNF626	7.93e-06	314	61	8	PF13912
Domain	ZINC_FINGER_C2H2_2	ZNF93 ZNF845 ZNF486 ZNF556 ZNF257 ZNF253 ZNF280C ZNF737 ZNF90 ZNF626	1.89e-04	775	61	10	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF93 ZNF845 ZNF486 ZNF556 ZNF257 ZNF253 ZNF280C ZNF737 ZNF90 ZNF626	1.93e-04	777	61	10	PS00028
Domain	Znf_C2H2-like	ZNF93 ZNF845 ZNF486 ZNF556 ZNF257 ZNF253 ZNF280C ZNF737 ZNF90 ZNF626	2.34e-04	796	61	10	IPR015880
Domain	Znf_C2H2	ZNF93 ZNF845 ZNF486 ZNF556 ZNF257 ZNF253 ZNF280C ZNF737 ZNF90 ZNF626	2.57e-04	805	61	10	IPR007087
Domain	ZnF_C2H2	ZNF93 ZNF845 ZNF486 ZNF556 ZNF257 ZNF253 ZNF280C ZNF737 ZNF90 ZNF626	2.64e-04	808	61	10	SM00355
Domain	HEMATOPO_REC_S_F1	IL2RB IL2RG	2.90e-04	8	61	2	PS01355
Domain	-	ZNF93 ZNF845 ZNF486 ZNF556 ZNF257 ZNF253 ZNF737 ZNF90 ZNF626	3.36e-04	679	61	9	3.30.160.60
Domain	Hempt_rcpt_S_F1_CS	IL2RB IL2RG	3.72e-04	9	61	2	IPR003531
Domain	zf-C2H2	ZNF93 ZNF845 ZNF486 ZNF556 ZNF257 ZNF253 ZNF737 ZNF90 ZNF626	3.90e-04	693	61	9	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF93 ZNF845 ZNF486 ZNF556 ZNF257 ZNF253 ZNF737 ZNF90 ZNF626	3.94e-04	694	61	9	IPR013087
Domain	HAT	ZFC3H1 XAB2	4.64e-04	10	61	2	IPR003107
Domain	HAT	ZFC3H1 XAB2	4.64e-04	10	61	2	SM00386
Domain	TPR-contain_dom	SMG7 ZFC3H1 CABIN1 XAB2	1.46e-03	150	61	4	IPR013026
Domain	RICIN	PLA2R1 GALNT6	3.76e-03	28	61	2	SM00458
Domain	RICIN_B_LECTIN	PLA2R1 GALNT6	3.76e-03	28	61	2	PS50231
Domain	ARF	ARF1 ARF3	4.02e-03	29	61	2	PS51417
Domain	Small_GTPase_ARF	ARF1 ARF3	4.02e-03	29	61	2	IPR024156
Domain	Ricin_B_lectin	PLA2R1 GALNT6	4.30e-03	30	61	2	IPR000772
Domain	Arf	ARF1 ARF3	4.59e-03	31	61	2	PF00025
Domain	Kringle-like	PLA2R1 HABP2	4.89e-03	32	61	2	IPR013806
Domain	Small_GTPase_ARF/SAR	ARF1 ARF3	5.19e-03	33	61	2	IPR006689
Domain	TPR-like_helical_dom	SMG7 ZFC3H1 CABIN1 XAB2	7.07e-03	233	61	4	IPR011990
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF93 ZNF845 ZNF486 ZNF257 ZNF253 ZNF737 ZNF90 ZNF626	1.23e-09	181	62	8	37372979
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF93 ZNF737 ZNF90	2.97e-06	16	62	3	8467795
Pubmed	Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera.	IL2RB IL2RG	3.13e-06	2	62	2	18589435
Pubmed	Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin.	ARF1 ARF3	3.13e-06	2	62	2	1577740
Pubmed	Assignment of human ADP ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42 and 12q13, respectively.	ARF1 ARF3	3.13e-06	2	62	2	8661066
Pubmed	Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin.	ARF1 ARF3	3.13e-06	2	62	2	2474826
Pubmed	Characterization of the human interleukin-2 receptor gamma chain gene.	IL2RB IL2RG	3.13e-06	2	62	2	8514792
Pubmed	The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface.	IL2RB IL2RG	3.13e-06	2	62	2	8648694
Pubmed	Glomerular common gamma chain confers B- and T-cell-independent protection against glomerulonephritis.	IL2RB IL2RG	3.13e-06	2	62	2	28111009
Pubmed	ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway.	ARF1 ARF3	3.13e-06	2	62	2	22971977
Pubmed	Alternate signalling pathways from the interleukin-2 receptor.	IL2RB IL2RG	3.13e-06	2	62	2	11750878
Pubmed	Characterization of Receptor-Associated Protein Complex Assembly in Interleukin (IL)-2- and IL-15-Activated T-Cell Lines.	IL2RB IL2RG	3.13e-06	2	62	2	27463037
Pubmed	Autoregulation of the 26S proteasome by in situ ubiquitination.	UBA1 UBR4 HUWE1	5.12e-06	19	62	3	24743594
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	TENM4 UBR4 NAV2 EIF2AK4 UNC79	8.16e-06	153	62	5	10718198
Pubmed	Soluble IL-2 receptor beta and gamma subunits: ligand binding and cooperativity.	IL2RB IL2RG	9.37e-06	3	62	2	8049354
Pubmed	Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.	IL2RB IL2RG	9.37e-06	3	62	2	8026467
Pubmed	GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines.	IL2RB IL2RG	9.37e-06	3	62	2	11856346
Pubmed	Clinical utility of soluble interleukin-2 receptor in hemophagocytic syndromes: a systematic scoping review.	IL2RB IL2RG	9.37e-06	3	62	2	28497365
Pubmed	Value of serum soluble interleukin-2 receptor as a diagnostic and predictive biomarker in sarcoidosis.	IL2RB IL2RG	9.37e-06	3	62	2	32248706
Pubmed	ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus.	ARF1 ARF3	9.37e-06	3	62	2	23783033
Pubmed	Oligomerization of IL-2Ralpha.	IL2RB IL2RG	9.37e-06	3	62	2	11886175
Pubmed	Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy.	IL2RB IL2RG	9.37e-06	3	62	2	28678791
Pubmed	Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors.	ARF1 ARF3	9.37e-06	3	62	2	10623590
Pubmed	Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis.	ARF1 ARF3	9.37e-06	3	62	2	26330566
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	UBR4 RLIM HUWE1	1.71e-05	28	62	3	35474067
Pubmed	Ligand-independent homomeric and heteromeric complexes between interleukin-2 or -9 receptor subunits and the gamma chain.	IL2RB IL2RG	1.87e-05	4	62	2	18829468
Pubmed	The interleukin-2 and interleukin-4 receptors studied by molecular modelling.	IL2RB IL2RG	1.87e-05	4	62	2	7529123
Pubmed	Lymphocyte activation by HIV-1 envelope glycoprotein.	IL2RB IL2RG	1.87e-05	4	62	2	2843775
Pubmed	IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development.	IL2RB IL2RG	1.87e-05	4	62	2	23315074
Pubmed	Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.	IL2RB IL2RG	1.87e-05	4	62	2	16293754
Pubmed	Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor.	IL2RB IL2RG	1.87e-05	4	62	2	8262055
Pubmed	Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.	IL2RB IL2RG	1.87e-05	4	62	2	7973659
Pubmed	Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID.	IL2RB IL2RG	1.87e-05	4	62	2	7973658
Pubmed	In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein.	IL2RB IL2RG	1.87e-05	4	62	2	18791162
Pubmed	TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation.	UBR4 HUWE1	1.87e-05	4	62	2	37324936
Pubmed	NEDD4-2 associates with gamma(c) and regulates its degradation rate.	IL2RB IL2RG	1.87e-05	4	62	2	19615332
Pubmed	The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium.	IL2RB IL2RG	1.87e-05	4	62	2	19846871
Pubmed	Interleukin-2 receptor beta and gamma chain dysregulation during the inhibition of CD4 T cell activation by human immunodeficiency virus-1 gp120.	IL2RB IL2RG	1.87e-05	4	62	2	9341758
Pubmed	Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.	IL2RB IL2RG	1.87e-05	4	62	2	16477002
Pubmed	Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA.	IL2RB IL2RG	1.87e-05	4	62	2	2315327
Pubmed	Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response.	IL2RB IL2RG	1.87e-05	4	62	2	11702064
Pubmed	Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains.	IL2RB IL2RG	1.87e-05	4	62	2	8041779
Pubmed	The Rag2⁻Il2rb⁻Dmd⁻ mouse: a novel dystrophic and immunodeficient model to assess innovating therapeutic strategies for muscular dystrophies.	IL2RB IL2RG	1.87e-05	4	62	2	23975040
Pubmed	Interleukin-2 and its receptor complex (alpha, beta and gamma chains) in in situ and infiltrative human breast cancer: an immunohistochemical comparative study.	IL2RB IL2RG	1.87e-05	4	62	2	14680494
Pubmed	Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells.	IL2RB IL2RG	1.87e-05	4	62	2	17371960
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ZNF93 AOC1 AOPEP MYPN DHX38 RLIM FAM216A EIF2AK4 HUWE1 DYNC1LI2	2.05e-05	1084	62	10	11544199
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	ANKRD31 PLA2R1 TENM4 MYPN ZNF280C HLA-E NAV2 IL2RG	2.57e-05	674	62	8	37196079
Pubmed	The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle.	UBA1 UBR4 HUWE1	2.58e-05	32	62	3	36278411
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	UBA1 UBR4 HUWE1 ELAC2 XAB2 ARF3	2.84e-05	332	62	6	32786267
Pubmed	Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes.	ARF1 ARF3	3.12e-05	5	62	2	9038142
Pubmed	gamma(c) cytokines provide multiple homeostatic signals to naive CD4(+) T cells.	IL2RB IL2RG	3.12e-05	5	62	2	17683114
Pubmed	IL-2Rbeta/IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte (IEL) developmental defects of gammac-/- mice: roles for both IL-2 and IL-15 in CD8alphaalpha IEL development.	IL2RB IL2RG	3.12e-05	5	62	2	10570276
Pubmed	Efficient xenoengraftment in severe immunodeficient NOD/Shi-scid IL2rγnull mice is attributed to a lack of CD11c+B220+CD122+ cells.	IL2RB IL2RG	3.12e-05	5	62	2	23018460
Pubmed	Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex.	IL2RB IL2RG	3.12e-05	5	62	2	23341462
Pubmed	Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain.	IL2RB IL2RG	3.12e-05	5	62	2	15123770
Pubmed	ADP-ribosylation factor is functionally and physically associated with the Golgi complex.	ARF1 ARF3	3.12e-05	5	62	2	2105501
Pubmed	N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.	NAA35 UBR4	3.12e-05	5	62	2	37891180
Pubmed	Cutting edge: JAK3 activation and rescue of T cells from HIV gp120-induced unresponsiveness.	IL2RB IL2RG	3.12e-05	5	62	2	9637477
Pubmed	Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.	IL2RB IL2RG	3.12e-05	5	62	2	7641685
Pubmed	Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells.	IL2RB IL2RG	4.67e-05	6	62	2	10725718
Pubmed	Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation.	IL2RB IL2RG	4.67e-05	6	62	2	19923221
Pubmed	IL-2 receptor signaling through the Shb adapter protein in T and NK cells.	IL2RB IL2RG	4.67e-05	6	62	2	12200137
Pubmed	Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB.	ZNF257 ZNF253	4.67e-05	6	62	2	10585455
Pubmed	The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15.	IL2RB IL2RG	4.67e-05	6	62	2	18390713
Pubmed	Gamma c cytokines condition the progressive differentiation of CD4+ T cells.	IL2RB IL2RG	4.67e-05	6	62	2	17855567
Pubmed	Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance.	HLA-E IL2RG	6.53e-05	7	62	2	20844537
Pubmed	CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells.	IL2RB IL2RG	6.53e-05	7	62	2	17923507
Pubmed	Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells.	RLIM HUWE1	6.53e-05	7	62	2	23362347
Pubmed	GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.	ARF1 ARF3	6.53e-05	7	62	2	11950392
Pubmed	IL-2 induces conformational changes in its preassembled receptor core, which then migrates in lipid raft and binds to the cytoskeleton meshwork.	IL2RB IL2RG	6.53e-05	7	62	2	20816854
Pubmed	Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells.	ARF1 ARF3	8.69e-05	8	62	2	8195219
Pubmed	Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6).	ARF1 ARF3	8.69e-05	8	62	2	8947846
Pubmed	A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells.	IL2RB IL2RG	8.69e-05	8	62	2	18566388
Pubmed	The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.	ZNF93 ZNF90	8.69e-05	8	62	2	2023909
Pubmed	Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development.	ARF1 ARF3	8.69e-05	8	62	2	38227057
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	NAA35 DST UBR4 HUWE1 SPAG17 UNC79 ARF1 ARF3	9.08e-05	807	62	8	30575818
Pubmed	Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.	UBA1 UBR4 HUWE1	9.96e-05	50	62	3	17550899
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	NAA35 UBA1 ZNF486 SMG7 UBR4 DHX38 RLIM EIF2AK4 EIPR1 XAB2	1.12e-04	1327	62	10	32694731
Pubmed	Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.	MALRD1 HLA-E	1.12e-04	9	62	2	20062062
Pubmed	Innate Lymphoid Cells in the Induction of Obesity.	IL2RB IL2RG	1.12e-04	9	62	2	31269440
Pubmed	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	UBA1 DST RLIM HUWE1 ARF1	1.25e-04	271	62	5	25737280
Pubmed	NLGN4X TCR transgenic T cells to treat gliomas.	HLA-E IL2RG	1.39e-04	10	62	2	37715782
Pubmed	Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model.	HLA-E IL2RG	1.39e-04	10	62	2	37712758
Pubmed	Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.	IL2RB IL2RG	1.39e-04	10	62	2	10825200
Pubmed	Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.	HLA-E IL2RG	1.39e-04	10	62	2	30383447
Pubmed	IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.	IL2RB IL2RG	1.39e-04	10	62	2	17182565
Pubmed	HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice.	HLA-E IL2RG	1.39e-04	10	62	2	37877672
Pubmed	Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγ(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells.	HLA-E IL2RG	1.39e-04	10	62	2	23869841
Pubmed	Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti-PD-1 Immune Checkpoint Inhibitor Cancer Therapy.	HLA-E IL2RG	1.39e-04	10	62	2	38426910
Pubmed	Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.	HLA-E IL2RG	1.39e-04	10	62	2	37219526
Pubmed	Antitumor activity of AZD0754, a dnTGFβRII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer.	HLA-E IL2RG	1.39e-04	10	62	2	37966111
Pubmed	Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors.	ARF1 ARF3	1.39e-04	10	62	2	10828067
Pubmed	Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.	UBR4 RLIM HUWE1	1.40e-04	56	62	3	27103069
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ERBB3 DST DHX38 EIF2AK4 GALNT6 CLSTN1 XAB2	1.56e-04	650	62	7	38777146
Pubmed	Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense.	IL2RB IL2RG	1.70e-04	11	62	2	19084435
Pubmed	A function for interleukin 2 in Foxp3-expressing regulatory T cells.	IL2RB IL2RG	1.70e-04	11	62	2	16227984
Pubmed	Expression of CD226 is associated to but not required for NK cell education.	HLA-E IL2RG	1.70e-04	11	62	2	28561023
Pubmed	UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.	UBR4 RLIM HUWE1	1.89e-04	62	62	3	18775313
Pubmed	Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells.	IL2RB IL2RG	2.04e-04	12	62	2	33326784
Pubmed	Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells.	IL2RB IL2RG	2.04e-04	12	62	2	20023630
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF93 ZNF486 ZNF257 ZNF737 ZNF90 ZNF626	1.69e-08	122	62	6	chr19p12
Cytoband	19p12	ZNF93 ZNF486 ZNF737 ZNF90 ZNF626	1.53e-07	90	62	5	19p12
Cytoband	12q13	ERBB3 GALNT6 ARF3	1.26e-04	71	62	3	12q13
Cytoband	10q25.3	AFAP1L2 HABP2	7.12e-04	29	62	2	10q25.3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF93 ZNF845 ZNF486 ZNF556 ZNF257 ZNF253 ZNF737 ZNF90 ZNF626	2.11e-05	718	40	9	28
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	ARF1 ARF3	2.13e-03	31	40	2	357
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL2RB IL2RG	3.89e-03	42	40	2	602
GeneFamily	C-type lectin domain family	PLA2R1 CLEC2L	4.84e-03	47	40	2	494
Coexpression	WANG_TUMOR_INVASIVENESS_DN	NAA35 ERBB3 SMG7 RLIM DYNC1LI2 ARF1	9.73e-06	211	61	6	M1866
Coexpression	WANG_TUMOR_INVASIVENESS_DN	NAA35 ERBB3 SMG7 RLIM DYNC1LI2 ARF1	1.14e-05	217	61	6	MM778
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-Z\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF556 HLA-E ZNF90 IL2RG ARF3	1.69e-06	143	62	5	eb11ff288cb91210383b288aa57715ebd59a52c3
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-Z\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF556 HLA-E ZNF90 IL2RB IL2RG	2.85e-06	159	62	5	bf8ff9251bcb64b2b9d6dd93461aec97659686ec
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_4\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	ERBB3 AOPEP ZNF280C IL2RB LARGE1	4.42e-06	174	62	5	110369f6b78de34a6d934b5b47cecd023347bc80
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_A\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GOLGA8S C18orf63 CASP10 PNLDC1 IL2RB	5.96e-06	185	62	5	25781cf68e693e97dc1885e2879ab24fa946b51e
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST SMG7 RLIM HUWE1 CLSTN1	8.49e-06	199	62	5	8d50e1ee58710d896c0204937331d9f4dcd38de0
Disease	level of triacylglycerol (56:6) in blood serum	ZNF93 ZNF90	4.79e-04	16	60	2	OBA_2020007
Disease	Benign neoplasm of stomach	ERBB3 CASP10	5.42e-04	17	60	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ERBB3 CASP10	5.42e-04	17	60	2	C0496905
Disease	Carcinoma in situ of stomach	ERBB3 CASP10	5.42e-04	17	60	2	C0154060
Disease	eotaxin measurement	HABP2 ANO10 LARGE1	5.87e-04	80	60	3	EFO_0008122
Disease	Stomach Carcinoma	ERBB3 CASP10	8.33e-04	21	60	2	C0699791
Disease	cortical surface area measurement	ERBB3 CLEC2L AOPEP NAV2 CD180 SPAG17 CLSTN1 ELAC2 ARF1	1.50e-03	1345	60	9	EFO_0010736

Protein segments in the cluster

Peptide	Gene	Start	Entry
ISANRQLCYHHSLNW	ERBB3	456	P21860
DWSQSQEELQEYCRH	EIF2AK4	1431	Q9P2K8
RWCSVRDNHLHFYQD	AFAP1L2	371	Q8N4X5
HSLRHRNWYIQATCA	ARF3	146	P61204
YHLQDQDAEVRHRWC	AOPEP	736	Q8N6M6
NQVCDEEWHHYVLNV	CLSTN1	451	O94985
ELCSSSIYHQNDPWH	AOC1	631	P19801
RCQINWIHEDTFQSH	CD180	86	Q99467
YWQERCHQKIHHLLS	GOLGA8S	476	H3BPF8
SWENHRLESAYQNHL	ANO10	386	Q9NW15
WHVYNENSNRQKLEH	ANKRD31	646	Q8N7Z5
HQRAYLEDTCVEWLH	HLA-E	176	P13747
WNVQLSDHTRSEQCY	LARGE1	356	O95461
LTWLYLDHNHICSVQ	LRRTM1	91	Q86UE6
EQQYQNVLTLWHESH	DST	956	Q03001
HTRCNVWILDGDLYH	DYNC1LI2	101	O43237
CLVLEYWRHQAQQRH	OPA3	96	Q9H6K4
VLYHNWRHAFNVCQL	PDE11A	661	Q9HCR9
NLCYHAQTRHWVIRS	HUWE1	3211	Q7Z6Z7
AQALLRWHDAHQFCS	NUDT13	156	Q86X67
WNVRYNHSHDQLVLT	EIPR1	276	Q53HC9
CQVQFWYHLSQHSNL	MALRD1	551	Q5VYJ5
NQHACLYWNSHLLLQ	HABP2	211	Q14520
WQEEDTFHSLCHQQQ	CABIN1	856	Q9Y6J0
LQLREQLHCHNFSWY	GALNT6	466	Q8NCL4
HRCNISWEISQASHY	IL2RB	146	P14784
LQHCYWTSHLQNERE	CALHM4	216	Q5JW98
HSLRHRNWYIQATCA	ARF1	146	P84077
ELNWNNRFLNHCLEH	IL2RG	171	P31785
HCLEHLVQYRTDWDH	IL2RG	181	P31785
HVEEGSWYIQSLCNH	CASP10	451	Q92851
QKQHYPCTTWRHQLE	FAM216A	161	Q8WUB2
HAVIERHSILSNWCY	C18orf63	186	Q68DL7
SNYQLWHELCDLISQ	XAB2	216	Q9HCS7
WLLELHHETQYCSIQ	TMEM26	81	Q6ZUK4
ARHNCYRELHNAWSV	RNF151	156	Q2KHN1
QHRWYLQNTSCDRES	PNLDC1	211	Q8NA58
EQHTYSQDEQLCWTQ	SMG7	316	Q92540
NLQLHHNFRWVLCAN	NAV2	2266	Q8IVL1
PFQYNHQWHHECTRE	PLA2R1	181	Q13018
LHCEYWNIALHSNVG	SPAG17	831	Q6Q759
WNTGRQYCHTHEAVL	CLEC2L	121	P0C7M8
HINTFLQHYCQAWEI	C17orf64	91	Q86WR6
NHWRIHNEERSYKCN	ZNF845	596	Q96IR2
EEWHCLDTAQRNLYR	ZNF93	16	P35789
AWLQQYHNQCQEVLH	ELAC2	586	Q9BQ52
QRQHLACLGTWVLYH	NAA35	481	Q5VZE5
EYHVHCIDRWLSENS	RLIM	591	Q9NVW2
EHSYCRQDINKEHLW	THAP5	321	Q7Z6K1
YCWATSFQRHVRIHN	ZNF556	296	Q9HAH1
NCYVTNHLNIQWLEL	UNQ5815/PRO19632	96	Q6UWF5
WNGEHCTIAHYLDRV	TENM4	781	Q6N022
NNYSTIWCNDHFIHA	DHX38	1021	Q92620
CHHWHTQYSNNIRQL	UBA1	711	P22314
EEWHCLDTAQRNLYR	ZNF626	16	Q68DY1
EEWHCLDTAQRNLYR	ZNF253	16	O75346
EEWHCLDTAQQNLYR	ZNF90	16	Q03938
NESWENHTTCQHCYR	ZNF280C	346	Q8ND82
WQAHCLTLHIYRNSS	UBR4	3426	Q5T4S7
EWHCLDTAQQNLYRD	ZNF486	26	Q96H40
DDDCQWQHIQDYTLS	ZFC3H1	1196	O60293
LQYTAWNPIHCQHIE	UNC79	296	Q9P2D8
EEWHCLDTAQQNLYR	ZNF257	16	Q9Y2Q1
EEWHCLDTAQRNLYR	ZNF737	16	O75373
SCTARLDIYAQWHHQ	MYPN	1256	Q86TC9