Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	KL MAN2B2 MAN2B1 GLB1L2 HEXD	7.81e-06	103	53	5	GO:0004553
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	KL MAN2B2 MAN2B1 GLB1L2 HEXD	3.95e-05	144	53	5	GO:0016798
GeneOntologyMolecularFunction	CTPase activity	ENTPD7 ENTPD4	1.03e-04	6	53	2	GO:0043273
GeneOntologyMolecularFunction	carbohydrate binding	SIGLEC12 MAN2B2 MAN2B1 PKD1 KLRG2 CRYBG3	1.66e-04	310	53	6	GO:0030246
GeneOntologyMolecularFunction	UDP phosphatase activity	ENTPD7 ENTPD4	2.46e-04	9	53	2	GO:0045134
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCNKA CLCNKB	3.74e-04	11	53	2	GO:0005247
GeneOntologyMolecularFunction	GDP phosphatase activity	ENTPD7 ENTPD4	4.49e-04	12	53	2	GO:0004382
GeneOntologyMolecularFunction	alpha-mannosidase activity	MAN2B2 MAN2B1	7.10e-04	15	53	2	GO:0004559
GeneOntologyMolecularFunction	mannosidase activity	MAN2B2 MAN2B1	8.10e-04	16	53	2	GO:0015923
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CACNA2D4 CLCNKA CLCNKB SLC31A2 PKD1 KCNN1 NDUFA8 SLC39A8	8.11e-04	758	53	8	GO:0015318
GeneOntologyMolecularFunction	voltage-gated monoatomic anion channel activity	CLCNKA CLCNKB	9.16e-04	17	53	2	GO:0008308
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNA2D4 MPC1L CLCNKA CLCNKB SLC31A2 PKD1 KCNN1 NDUFA8 SLC25A16 SLC39A8	9.50e-04	1180	53	10	GO:0022857
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA2D4 CLCNKA CLCNKB SLC31A2 PKD1 KCNN1 NDUFA8 SLC39A8	1.09e-03	793	53	8	GO:0015075
GeneOntologyMolecularFunction	nucleoside diphosphate phosphatase activity	ENTPD7 ENTPD4	1.27e-03	20	53	2	GO:0017110
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA2D4 CLCNKA CLCNKB KCNN1	1.38e-03	182	53	4	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA2D4 CLCNKA CLCNKB KCNN1	1.44e-03	184	53	4	GO:0022832
GeneOntologyMolecularFunction	transporter activity	CACNA2D4 MPC1L CLCNKA CLCNKB SLC31A2 PKD1 KCNN1 NDUFA8 SLC25A16 SLC39A8	1.85e-03	1289	53	10	GO:0005215
GeneOntologyBiologicalProcess	UDP catabolic process	ENTPD7 ENTPD4	1.94e-05	3	53	2	GO:0006256
GeneOntologyBiologicalProcess	pyrimidine nucleoside diphosphate catabolic process	ENTPD7 ENTPD4	1.94e-05	3	53	2	GO:0009140
GeneOntologyBiologicalProcess	pyrimidine ribonucleoside diphosphate catabolic process	ENTPD7 ENTPD4	1.94e-05	3	53	2	GO:0009195
GeneOntologyBiologicalProcess	UDP metabolic process	ENTPD7 ENTPD4	1.35e-04	7	53	2	GO:0046048
GeneOntologyBiologicalProcess	pyrimidine ribonucleoside diphosphate metabolic process	ENTPD7 ENTPD4	1.35e-04	7	53	2	GO:0009193
HumanPheno	Hypokalemic hypochloremic metabolic alkalosis	CLCNKA CLCNKB	4.38e-05	3	20	2	HP:0004909
HumanPheno	Abnormal parathyroid morphology	KL GCM2 CLCNKB	8.72e-05	23	20	3	HP:0011766
HumanPheno	Hypochloremic metabolic alkalosis	CLCNKA CLCNKB	8.75e-05	4	20	2	HP:0005977
HumanPheno	Abnormal urine output	KL CLCNKA CLCNKB ACE	1.27e-04	69	20	4	HP:0012590
HumanPheno	Abnormal blood inorganic cation concentration	KL GCM2 CLCNKA CLCNKB SLC39A8 DNMT3A	1.28e-04	216	20	6	HP:0010927
HumanPheno	Abnormal urine chloride concentration	CLCNKA CLCNKB	1.45e-04	5	20	2	HP:0012600
HumanPheno	Hyperchloriduria	CLCNKA CLCNKB	1.45e-04	5	20	2	HP:0002914
HumanPheno	Abnormality of renal excretion	KL CLCNKA CLCNKB ACE	1.76e-04	75	20	4	HP:0011036
HumanPheno	Abnormal glomerular filtration rate	CLCNKA CLCNKB PKD1	1.77e-04	29	20	3	HP:0012212
HumanPheno	Decreased glomerular filtration rate	CLCNKA CLCNKB PKD1	1.77e-04	29	20	3	HP:0012213
HumanPheno	Hypomagnesemia	GCM2 CLCNKA CLCNKB	2.17e-04	31	20	3	HP:0002917
HumanPheno	Abnormal circulating prostaglandin circulation	CLCNKA CLCNKB	2.18e-04	6	20	2	HP:0011023
HumanPheno	Hyperprostaglandinuria	CLCNKA CLCNKB	2.18e-04	6	20	2	HP:0003527
HumanPheno	Neoplasm of the endocrine system	MSH6 GCM2 CLCNKB PKD1 DNMT3A	2.62e-04	155	20	5	HP:0100568
HumanPheno	Abnormal magnesium concentration	GCM2 CLCNKA CLCNKB	2.87e-04	34	20	3	HP:0004921
HumanPheno	Impaired renal concentrating ability	CLCNKA CLCNKB	3.04e-04	7	20	2	HP:0004727
HumanPheno	Hypochloremia	CLCNKA CLCNKB	3.04e-04	7	20	2	HP:0003113
HumanPheno	Abnormal circulating unsaturated fatty acid concentration	CLCNKA CLCNKB	4.04e-04	8	20	2	HP:0011022
HumanPheno	Hyperactive renin-angiotensin system	CLCNKA CLCNKB	4.04e-04	8	20	2	HP:0000841
HumanPheno	Abnormal circulating eicosanoid concentration	CLCNKA CLCNKB	4.04e-04	8	20	2	HP:0030361
HumanPheno	Polyuria	KL CLCNKA CLCNKB	4.66e-04	40	20	3	HP:0000103
HumanPheno	Hypokalemic metabolic alkalosis	CLCNKA CLCNKB	5.19e-04	9	20	2	HP:0001960
HumanPheno	Increased urinary potassium	CLCNKA CLCNKB	5.19e-04	9	20	2	HP:0003081
HumanPheno	Impaired renal function	CLCNKA CLCNKB	5.19e-04	9	20	2	HP:0000087
HumanPheno	Hypernatriuria	CLCNKA CLCNKB	6.47e-04	10	20	2	HP:0012605
HumanPheno	Abnormal urine anion concentration	GCM2 CLCNKA CLCNKB	7.52e-04	47	20	3	HP:0011866
HumanPheno	Atrioventricular valve regurgitation	MAN2B1 MEGF8 LOX PKD1 DNMT3A	7.75e-04	196	20	5	HP:0034376
MousePheno	abnormal systemic artery morphology	DMXL2 KL MEGF8 CLCNKB LOX PKD1 ACE	3.61e-06	304	31	7	MP:0011655
MousePheno	hypotension	CLCNKB ACE SLC39A8	3.12e-05	28	31	3	MP:0001596
MousePheno	abnormal artery morphology	DMXL2 KL MEGF8 CLCNKB LOX PKD1 ACE	3.98e-05	440	31	7	MP:0002191
MousePheno	decreased systemic arterial blood pressure	ASNSD1 CLCNKB ACE SLC39A8	7.79e-05	104	31	4	MP:0002843
MousePheno	abnormal parathyroid gland physiology	GCM2 PKD1	1.32e-04	8	31	2	MP:0003431
MousePheno	abnormal kidney medulla morphology	KL PKD1 ACE	1.70e-04	49	31	3	MP:0003014
MousePheno	abnormal blood vessel morphology	GXYLT2 DMXL2 CACNA2D4 KL MAN2B1 MEGF8 CLCNKB LOX PKD1 NDUFA8 ACE	1.95e-04	1472	31	11	MP:0001614
MousePheno	decreased urine osmolality	CLCNKA CLCNKB ACE	2.27e-04	54	31	3	MP:0002988
MousePheno	small kidney	KL MEGF8 CLCNKB LOX IRF3 ACE	2.94e-04	425	31	6	MP:0002989
MousePheno	abnormal urine osmolality	CLCNKA CLCNKB ACE	3.93e-04	65	31	3	MP:0002987
MousePheno	aortic aneurysm	LOX PKD1	4.26e-04	14	31	2	MP:0006278
MousePheno	kidney medulla cyst	PKD1 ACE	4.26e-04	14	31	2	MP:0011307
MousePheno	abnormal atrioventricular valve morphology	KL MEGF8 PKD1	4.69e-04	69	31	3	MP:0002745
MousePheno	increased phosphate level	KL GCM2 IRF3 SLC39A8	4.70e-04	166	31	4	MP:0014545
MousePheno	increased circulating phosphate level	KL GCM2 IRF3 SLC39A8	4.70e-04	166	31	4	MP:0001566
MousePheno	abnormal urine homeostasis	MAN2B1 GCM2 CLCNKA CLCNKB ACE SLC39A8	4.81e-04	466	31	6	MP:0009643
MousePheno	abnormal kidney arterial blood vessel morphology	CLCNKB ACE	5.60e-04	16	31	2	MP:0011309
MousePheno	abnormal heart atrium and ventricle connection	KL MEGF8 PKD1	5.99e-04	75	31	3	MP:0010435
Domain	Cl_channel-K	CLCNKA CLCNKB	8.51e-06	2	55	2	IPR002250
Domain	-	MAN2B2 MAN2B1	8.47e-05	5	55	2	1.20.1270.50
Domain	-	MAN2B2 MAN2B1	8.47e-05	5	55	2	3.20.110.10
Domain	Glyco_hydro_38_C	MAN2B2 MAN2B1	8.47e-05	5	55	2	IPR011682
Domain	RDM	RFPL4A RFPL4AL1	8.47e-05	5	55	2	PF11002
Domain	Alpha-mann_mid	MAN2B2 MAN2B1	8.47e-05	5	55	2	SM00872
Domain	Alpha-mann_mid	MAN2B2 MAN2B1	8.47e-05	5	55	2	PF09261
Domain	Glyco_hydro_38_N	MAN2B2 MAN2B1	8.47e-05	5	55	2	IPR000602
Domain	Glyco_hydro_38/57_N	MAN2B2 MAN2B1	8.47e-05	5	55	2	IPR027291
Domain	RDM_domain_RFPL	RFPL4A RFPL4AL1	8.47e-05	5	55	2	IPR022723
Domain	Glyco_hydro_38_cen	MAN2B2 MAN2B1	8.47e-05	5	55	2	IPR015341
Domain	Glyco_hydro_57/38_cen	MAN2B2 MAN2B1	8.47e-05	5	55	2	IPR028995
Domain	Glyco_hydro_38C	MAN2B2 MAN2B1	8.47e-05	5	55	2	PF07748
Domain	Glyco_hydro_38	MAN2B2 MAN2B1	8.47e-05	5	55	2	PF01074
Domain	-	KL GLB1L2 HEXD	1.48e-04	35	55	3	3.20.20.80
Domain	Glyco_hydro/deAcase_b/a-brl	MAN2B2 MAN2B1	1.77e-04	7	55	2	IPR011330
Domain	TLV_coat	ERVV-2 ERVV-1	1.77e-04	7	55	2	PF00429
Domain	Glyco_hydro_catalytic_dom	KL GLB1L2 HEXD	1.89e-04	38	55	3	IPR013781
Domain	GDA1_CD39_NTPase	ENTPD7 ENTPD4	2.36e-04	8	55	2	IPR000407
Domain	TLV/ENV_coat_polyprotein	ERVV-2 ERVV-1	2.36e-04	8	55	2	IPR018154
Domain	GDA1_CD39	ENTPD7 ENTPD4	2.36e-04	8	55	2	PF01150
Domain	GDA1_CD39_NTPASE	ENTPD7 ENTPD4	2.36e-04	8	55	2	PS01238
Domain	Cl-channel_core	CLCNKA CLCNKB	3.02e-04	9	55	2	IPR014743
Domain	-	CLCNKA CLCNKB	3.02e-04	9	55	2	1.10.3080.10
Domain	Voltage_CLC	CLCNKA CLCNKB	3.02e-04	9	55	2	PF00654
Domain	Cl-channel_volt-gated	CLCNKA CLCNKB	3.02e-04	9	55	2	IPR001807
Domain	ConA-like_dom	RFPL4A CNTNAP1 USH2A MAMDC4 RFPL4AL1	4.57e-04	219	55	5	IPR013320
Domain	Glycoside_hydrolase_SF	KL GLB1L2 HEXD	5.10e-04	53	55	3	IPR017853
Domain	-	MAN2B2 MAN2B1	7.57e-04	14	55	2	2.60.40.1180
Domain	Glyco_hydro_b	MAN2B2 MAN2B1	8.72e-04	15	55	2	IPR013780
Domain	CBS	CLCNKA CLCNKB	9.95e-04	16	55	2	SM00116
Domain	Gal_mutarotase_SF_dom	MAN2B2 MAN2B1	1.13e-03	17	55	2	IPR011013
Domain	CBS_dom	CLCNKA CLCNKB	1.56e-03	20	55	2	IPR000644
Domain	CBS	CLCNKA CLCNKB	1.56e-03	20	55	2	PF00571
Domain	CBS	CLCNKA CLCNKB	1.56e-03	20	55	2	PS51371
Domain	PWWP	MSH6 DNMT3A	1.56e-03	20	55	2	SM00293
Domain	PLAT	PKD1 PNLIPRP3	1.72e-03	21	55	2	PS50095
Domain	-	PKD1 PNLIPRP3	1.72e-03	21	55	2	2.60.60.20
Domain	PLAT	PKD1 PNLIPRP3	1.72e-03	21	55	2	PF01477
Domain	PLAT/LH2_dom	PKD1 PNLIPRP3	1.72e-03	21	55	2	IPR001024
Domain	PWWP	MSH6 DNMT3A	2.07e-03	23	55	2	PF00855
Domain	PWWP_dom	MSH6 DNMT3A	2.07e-03	23	55	2	IPR000313
Domain	PWWP	MSH6 DNMT3A	2.25e-03	24	55	2	PS50812
Domain	Fibrinogen_C	ANGPT4 CNTNAP1	2.85e-03	27	55	2	PF00147
Domain	FBG	ANGPT4 CNTNAP1	3.29e-03	29	55	2	SM00186
Domain	-	ANGPT4 CNTNAP1	3.51e-03	30	55	2	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	ANGPT4 CNTNAP1	3.51e-03	30	55	2	IPR014716
Domain	EGF_LAM_2	MEGF8 USH2A	3.51e-03	30	55	2	PS50027
Domain	EGF_LAM_1	MEGF8 USH2A	3.51e-03	30	55	2	PS01248
Domain	FIBRINOGEN_C_1	ANGPT4 CNTNAP1	3.99e-03	32	55	2	PS00514
Domain	Fibrinogen_a/b/g_C_dom	ANGPT4 CNTNAP1	3.99e-03	32	55	2	IPR002181
Domain	FIBRINOGEN_C_2	ANGPT4 CNTNAP1	3.99e-03	32	55	2	PS51406
Domain	Laminin_EGF	MEGF8 USH2A	4.76e-03	35	55	2	PF00053
Domain	EGF_Lam	MEGF8 USH2A	4.76e-03	35	55	2	SM00180
Domain	LAM_G_DOMAIN	CNTNAP1 USH2A	5.59e-03	38	55	2	PS50025
Domain	Laminin_EGF	MEGF8 USH2A	5.59e-03	38	55	2	IPR002049
Domain	Laminin_G_2	CNTNAP1 USH2A	6.18e-03	40	55	2	PF02210
Domain	PRY	RFPL4A RFPL4AL1	6.80e-03	42	55	2	PF13765
Domain	LamG	CNTNAP1 USH2A	7.44e-03	44	55	2	SM00282
Pathway	REACTOME_PHOSPHATE_BOND_HYDROLYSIS_BY_NTPDASE_PROTEINS	ENTPD7 ENTPD4	1.96e-04	8	38	2	M27737
Pathway	REACTOME_PHOSPHATE_BOND_HYDROLYSIS_BY_NTPDASE_PROTEINS	ENTPD7 ENTPD4	1.96e-04	8	38	2	MM15486
Pubmed	Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney.	CLCNKA CLCNKB	2.55e-06	2	56	2	8544406
Pubmed	Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding properties.	MAN2B2 MAN2B1	2.55e-06	2	56	2	19722277
Pubmed	The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.	CLCNKA CLCNKB	2.55e-06	2	56	2	27335120
Pubmed	Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization.	CLCNKA CLCNKB	2.55e-06	2	56	2	8812470
Pubmed	Associations between CLCNKA_B tag SNPs with essential hypertension and interactions between genetic and environmental factors in an island population in China.	CLCNKA CLCNKB	2.55e-06	2	56	2	25919862
Pubmed	Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes.	CLCNKA CLCNKB	2.55e-06	2	56	2	24863058
Pubmed	Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel.	CLCNKA CLCNKB	2.55e-06	2	56	2	9916798
Pubmed	Kidney kinetics and chloride ion pumps.	CLCNKA CLCNKB	2.55e-06	2	56	2	9916791
Pubmed	Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.	ERVV-2 ERVV-1	2.55e-06	2	56	2	18826608
Pubmed	Expanding Genotype-Phenotype Correlation of CLCNKA and CLCNKB Variants Linked to Hearing Loss.	CLCNKA CLCNKB	2.55e-06	2	56	2	38069401
Pubmed	Immunohistochemical evaluation of Klotho and DNA methyltransferase 3a in oral squamous cell carcinomas.	KL DNMT3A	2.55e-06	2	56	2	28303350
Pubmed	A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.	CLCNKA CLCNKB	2.55e-06	2	56	2	20805576
Pubmed	Salt wasting and deafness resulting from mutations in two chloride channels.	CLCNKA CLCNKB	2.55e-06	2	56	2	15044642
Pubmed	Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.	ERVV-2 ERVV-1	2.55e-06	2	56	2	23555306
Pubmed	Two highly homologous members of the ClC chloride channel family in both rat and human kidney.	CLCNKA CLCNKB	2.55e-06	2	56	2	8041726
Pubmed	A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane.	CLCNKA CLCNKB	2.55e-06	2	56	2	18648499
Pubmed	Cl(-) channels in basolateral TAL membranes XV. Molecular heterogeneity between cortical and medullary channels.	CLCNKA CLCNKB	2.55e-06	2	56	2	11014860
Pubmed	Human CLC-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be Functional.	CLCNKA CLCNKB	7.63e-06	3	56	2	26013830
Pubmed	Barttin increases surface expression and changes current properties of ClC-K channels.	CLCNKA CLCNKB	7.63e-06	3	56	2	12111250
Pubmed	Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension.	CLCNKA CLCNKB	7.63e-06	3	56	2	17510212
Pubmed	Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.	CLCNKA CLCNKB	7.63e-06	3	56	2	11734858
Pubmed	Barttin modulates trafficking and function of ClC-K channels.	CLCNKA CLCNKB	7.63e-06	3	56	2	16849430
Pubmed	Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance.	CLCNKA CLCNKB	7.63e-06	3	56	2	18094726
Pubmed	Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor.	CLCNKA CLCNKB	7.63e-06	3	56	2	10982849
Pubmed	Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.	ENTPD7 CH25H ACE	1.26e-05	28	56	3	20534741
Pubmed	Haplotype diversity in four genes (CLCNKA, CLCNKB, BSND, NEDD4L) involved in renal salt reabsorption.	CLCNKA CLCNKB	1.52e-05	4	56	2	17652939
Pubmed	The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.	RFPL4A RFPL4AL1	2.54e-05	5	56	2	11850190
Pubmed	Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.	ERVV-2 ERVV-1	3.80e-05	6	56	2	23085571
Pubmed	Impairment in renal medulla development underlies salt wasting in Clc-k2 channel deficiency.	CLCNKA CLCNKB	5.32e-05	7	56	2	34499620
Pubmed	Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney.	CLCNKA CLCNKB	5.32e-05	7	56	2	11423561
Pubmed	Syncytins expressed in human placental trophoblast.	ERVV-2 ERVV-1	7.09e-05	8	56	2	33504453
Pubmed	RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.	RFPL4A RFPL4AL1	7.09e-05	8	56	2	12525704
Pubmed	Changing expression of chloride channels during preimplantation mouse development.	CLCNKA CLCNKB	9.10e-05	9	56	2	23115349
Pubmed	A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.	MSH6 DNMT3A	2.29e-04	14	56	2	26912663
Pubmed	Parathyroid hormone regulates fetal-placental mineral homeostasis.	GCM2 SLC39A8	2.64e-04	15	56	2	19968565
Pubmed	Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.	MAN2B2 MAN2B1	2.64e-04	15	56	2	8892864
Pubmed	Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.	CH25H ACE	3.41e-04	17	56	2	20413850
Pubmed	Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.	MAN2B2 MAN2B1	3.41e-04	17	56	2	2355006
Pubmed	Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.	MAN2B2 MAN2B1	4.75e-04	20	56	2	12560567
Pubmed	Identification and proteomic profiling of exosomes in human urine.	PKD1 ACE	5.24e-04	21	56	2	15326289
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	MEGF8 LOX PKD1	5.72e-04	100	56	3	25807483
Pubmed	Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.	MAN2B2 MAN2B1	5.76e-04	22	56	2	8673525
Pubmed	Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation.	MAN2B2 MAN2B1	5.76e-04	22	56	2	9109416
Pubmed	Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.	MAN2B2 MAN2B1	5.76e-04	22	56	2	11530211
Pubmed	Assessment of Alzheimer's disease case-control associations using family-based methods.	CH25H ACE	5.76e-04	22	56	2	18830724
Pubmed	Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function.	MAN2B2 MAN2B1	6.30e-04	23	56	2	1736542
Pubmed	Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.	MAN2B2 MAN2B1	6.30e-04	23	56	2	8093218
Pubmed	Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.	MAN2B2 MAN2B1	6.30e-04	23	56	2	3099781
Pubmed	Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.	MAN2B2 MAN2B1	6.30e-04	23	56	2	3264072
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ENTPD7 GXYLT2 MAN2B2 MAN2B1 MEGF8 LOX CNTNAP1 GLB1L2	6.44e-04	1201	56	8	35696571
Pubmed	Genetic variation in healthy oldest-old.	KL DNMT3A	6.87e-04	24	56	2	19680556
Pubmed	Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.	MAN2B2 MAN2B1	7.46e-04	25	56	2	2283726
Pubmed	Intermediate phenotypes identify divergent pathways to Alzheimer's disease.	CH25H ACE	7.46e-04	25	56	2	20574532
Pubmed	Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.	MAN2B2 MAN2B1	8.07e-04	26	56	2	8218172
Pubmed	Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.	MEGF8 PRPF4	9.37e-04	28	56	2	28655764
Pubmed	Heritable Thoracic Aortic Disease Overview	LOX PKD1	1.08e-03	30	56	2	20301299
Pubmed	ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles.	RFPL4A RFPL4AL1	1.15e-03	31	56	2	31657143
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	OR51L1 MSH6 PTPRN2 PKD1 GAL3ST2 SLC25A16	1.16e-03	736	56	6	29676528
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CLCNKA CLCNKB KCNN1	1.48e-03	139	56	3	16985003
Interaction	SLURP1 interactions	ASNSD1 DMXL2 MAN2B2 MAN2B1 MEGF8 CNTNAP1	1.86e-06	144	52	6	int:SLURP1
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	SIGLEC12 RFPL4A ERVV-2 MEGF8 KIR3DL3 IRF3 ERVV-1 RFPL4AL1	9.49e-05	1192	56	8	chr19q13
Cytoband	19q13.42	RFPL4A KIR3DL3 RFPL4AL1	4.92e-04	125	56	3	19q13.42
Cytoband	7q36	BLACE PTPRN2	5.03e-04	27	56	2	7q36
Cytoband	1p36	CLCNKA CLCNKB	1.53e-03	47	56	2	1p36
Cytoband	Ensembl 112 genes in cytogenetic band chr9q32	SLC31A2 PRPF4	1.72e-03	50	56	2	chr9q32
GeneFamily	Mannosidases alpha class 2	MAN2B2 MAN2B1	3.84e-05	5	36	2	1194
GeneFamily	Chloride voltage-gated channels	CLCNKA CLCNKB	1.72e-04	10	36	2	302
GeneFamily	PWWP domain containing	MSH6 DNMT3A	8.68e-04	22	36	2	1147
Drug	Methapyrilene hydrochloride [135-23-9]; Up 200; 13.4uM; PC3; HT_HG-U133A	LOX HSD17B6 ACE THAP9 ENTPD4 DNMT3A	5.83e-06	194	53	6	6644_UP
Drug	4-methylumbelliferone	SIGLEC12 MAN2B2 MAN2B1 GAL3ST2 HEXD	1.39e-05	132	53	5	CID003364573
Drug	mibefradil	CACNA2D4 PKD1 KCNN1 ACE	1.50e-05	64	53	4	CID000060662
Drug	(3S,4S)-pyrrolidine-3,4-diol	MAN2B2 MAN2B1	1.59e-05	3	53	2	CID000146198
Drug	methyl oligobiosaminide	MAN2B2 MAN2B1	1.59e-05	3	53	2	CID003083102
Drug	(1R,2R,3S,4R)-4-aminocyclopentane-1,2,3-triol	MAN2B2 MAN2B1	1.59e-05	3	53	2	CID010034676
Drug	Man)6(GlcNAc)2Asn	MAN2B2 MAN2B1	1.59e-05	3	53	2	CID000170160
Drug	oligostatin C	MAN2B2 MAN2B1	1.59e-05	3	53	2	CID000174107
Drug	B-792	MAN2B2 MAN2B1	3.18e-05	4	53	2	CID003060720
Drug	citronellyl alpha-D-mannopyranosyl phosphate	MAN2B2 MAN2B1	3.18e-05	4	53	2	CID000191367
Drug	Man)5(GlcNAc)2Asn	MAN2B2 MAN2B1	3.18e-05	4	53	2	CID003082495
Drug	benzyl-alpha-D-mannopyranoside	MAN2B2 MAN2B1	3.18e-05	4	53	2	CID000188977
Drug	msdC	MAN2B2 MAN2B1	3.18e-05	4	53	2	CID000131526
Drug	mannonolactam amidrazone	MAN2B2 MAN2B1	3.18e-05	4	53	2	CID000126858
Drug	4-methylumbelliferyl	KL MAN2B2 MAN2B1 GAL3ST2	4.20e-05	83	53	4	CID000011833
Drug	(2S,3S,4R,5R,6S)-2,6-difluoro-2-(hydroxymethyl)oxane-3,4,5-triol	MAN2B2 MAN2B1	5.29e-05	5	53	2	CID010013013
Drug	didecyl sulfate	MAN2B2 MAN2B1	5.29e-05	5	53	2	CID011760650
Drug	alpha-ManMNT	MAN2B2 MAN2B1	5.29e-05	5	53	2	CID006438897
Drug	2-Methyl-4-chlorophenoxyacetic Acid	CLCNKA CLCNKB	5.29e-05	5	53	2	ctd:D008456
Drug	FP 6	KL LOX	5.29e-05	5	53	2	CID000077372
Drug	AC1L8Y60	GCM2 CLCNKA CLCNKB ACE	5.52e-05	89	53	4	CID000410009
Drug	1-deoxycastanospermine	MAN2B2 MAN2B1	7.93e-05	6	53	2	CID000195154
Drug	5-amino-5-deoxy-D-mannopyranose	MAN2B2 MAN2B1	7.93e-05	6	53	2	CID000124624
Drug	cyclic oxamide	MAN2B2 MAN2B1	7.93e-05	6	53	2	CID000468476
Drug	naphthol-AS-BI	KL MAN2B2 MAN2B1	8.75e-05	37	53	3	CID000071060
Drug	alpha-Santonin [481-06-1]; Up 200; 16.2uM; PC3; HT_HG-U133A	MEGF8 SLC31A2 PTPRN2 HSD17B6 SLC39A8	8.78e-05	194	53	5	4531_UP
Drug	Lithocholic acid [434-13-9]; Up 200; 10.6uM; PC3; HT_HG-U133A	ENTPD7 PTPRN2 HSD17B6 KCNN1 ENTPD4	9.22e-05	196	53	5	4551_UP
Drug	CP-320650-01 [172079-28-6]; Up 200; 1uM; PC3; HT_HG-U133A	PTPRN2 HSD17B6 KCNN1 ENTPD4 SLC39A8	9.90e-05	199	53	5	4560_UP
Drug	iminocyclitol	MAN2B2 MAN2B1	1.11e-04	7	53	2	CID011298136
Drug	HJ4	MAN2B2 MAN2B1	1.11e-04	7	53	2	CID005493402
Drug	Plantagoside	MAN2B2 MAN2B1	1.11e-04	7	53	2	CID000174157
Drug	4'-hydroxywogonin	MAN2B2 MAN2B1	1.11e-04	7	53	2	CID005322078
Drug	DMAPN	KL LOX	1.48e-04	8	53	2	CID000015615
Drug	rhamnose	SIGLEC12 CACNA2D4 MAN2B2 MAN2B1 GAL3ST2 ACE	1.73e-04	356	53	6	CID000000840
Drug	AC1L9MXH	KL MAN2B2 MAN2B1	2.03e-04	49	53	3	CID000449271
Drug	( )-Calystegine A3	MAN2B2 MAN2B1	2.36e-04	10	53	2	CID000183073
Drug	Man(6)GlcNAc(2	MAN2B2 MAN2B1	2.36e-04	10	53	2	CID003081584
Drug	Dfj	MAN2B2 MAN2B1	2.36e-04	10	53	2	CID009549198
Disease	Bartter disease type 4B	CLCNKA CLCNKB	3.05e-06	2	52	2	cv:C4310805
Disease	BARTTER SYNDROME, TYPE 4B	CLCNKA CLCNKB	3.05e-06	2	52	2	C2751312
Disease	BARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS	CLCNKA CLCNKB	3.05e-06	2	52	2	C4310805
Disease	Bartter disease type 3 (implicated_via_orthology)	CLCNKA CLCNKB	3.05e-06	2	52	2	DOID:0110144 (implicated_via_orthology)
Disease	Bartter disease type 4b (is_implicated_in)	CLCNKA CLCNKB	3.05e-06	2	52	2	DOID:0110146 (is_implicated_in)
Disease	BARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS	CLCNKA CLCNKB	3.05e-06	2	52	2	613090
Disease	Bartter disease (implicated_via_orthology)	CLCNKA CLCNKB	3.05e-06	2	52	2	DOID:445 (implicated_via_orthology)
Disease	Bartter syndrome	CLCNKA CLCNKB	4.55e-05	6	52	2	cv:C0004775
Disease	verbal-numerical reasoning measurement	DMXL2 PTPRN2 WWP2 SLC39A8	8.52e-05	131	52	4	EFO_0008394
Disease	abdominal aortic aneurysm (implicated_via_orthology)	LOX ACE	1.09e-04	9	52	2	DOID:7693 (implicated_via_orthology)
Disease	nephrogenic diabetes insipidus (implicated_via_orthology)	CLCNKA CLCNKB	1.36e-04	10	52	2	DOID:12387 (implicated_via_orthology)
Disease	chronic musculoskeletal pain	WWP2 SLC39A8	1.99e-04	12	52	2	EFO_0022195
Disease	heart failure	CLCNKA PKD1 CH25H SLC39A8	3.20e-04	185	52	4	EFO_0003144
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	PKD1 ACE	3.60e-04	16	52	2	DOID:0110861 (implicated_via_orthology)
Disease	susceptibility to scarlet fever measurement	PTPRN2 AOAH SLC25A16	3.71e-04	79	52	3	EFO_0008409
Disease	schizophrenia, inflammatory bowel disease	IRF3 SLC39A8	4.58e-04	18	52	2	EFO_0003767, MONDO_0005090
Disease	nucleus accumbens volume	USH2A SLC39A8	6.88e-04	22	52	2	EFO_0006931
Disease	urate measurement, bone density	GXYLT2 PTPRN2 AOAH USH2A THAP9 ENTPD4	7.46e-04	619	52	6	EFO_0003923, EFO_0004531
Disease	chronic myeloid leukemia (is_marker_for)	ACE DNMT3A	1.04e-03	27	52	2	DOID:8552 (is_marker_for)
Disease	retinitis pigmentosa (implicated_via_orthology)	PRPF4 USH2A	1.04e-03	27	52	2	DOID:10584 (implicated_via_orthology)
Disease	hypertension (is_implicated_in)	CLCNKB LOX ACE	1.28e-03	121	52	3	DOID:10763 (is_implicated_in)
Disease	waist-hip ratio	DMXL2 MEGF8 WWP2 HSD17B6 PKD1 KIAA1328 SLC39A8 DNMT3A	1.28e-03	1226	52	8	EFO_0004343
Disease	hypertension (implicated_via_orthology)	KL LOX ACE	1.51e-03	128	52	3	DOID:10763 (implicated_via_orthology)
Disease	heart function measurement	CLCNKA CH25H	1.65e-03	34	52	2	EFO_0004311
Disease	IGA Glomerulonephritis	MAN2B1 ACE	1.65e-03	34	52	2	C0017661

Protein segments in the cluster

Peptide	Gene	Start	Entry
FWYHGSLRSPGTLRV	MAMDC4	891	Q6UXC1
WTPFYQRGHNSTFFG	CNTNAP1	111	P78357
GGSTHAWLYLTRHFP	BLACE	91	A4D250
RRGSAPWHSFSRFFA	CRYBG3	6	Q68DQ2
SAAHRARYFWGNLPG	DNMT3A	786	Q9Y6K1
WGVFSGRTPPSRYNF	ACE	476	P12821
IAPWGGFTYHDVTLR	ERVV-2	336	B6SEH9
FVYLAHPRAVTGFSW	DMXL2	226	Q8TDJ6
GHWSLTRPGVFYIGR	DNAI3	721	Q8IWG1
GGPTTRRDFYWLRSF	SLC25A16	26	P16260
PRGWSFGIRHSDYLA	ODF3B	231	A8MYP8
FHFLSWYDRGVPSSS	PTPRN2	906	Q92932
SVFPTLRGYHWRGRD	AOAH	191	P28039
HYFLNTGSLSPFARW	PNLIPRP3	341	Q17RR3
RYEFLWGPRAHAETS	MAGEB18	266	Q96M61
GSSGSRIFVYFWPRH	ENTPD7	91	Q9NQZ7
REYVSSTHFWGPAFS	MPC1L	21	P0DKB6
VPGHYRFTWTARLAF	KCNN1	201	Q92952
IAPWGGFTYHDVTLR	ERVV-1	336	B6SEH8
LRGFPGLEYVHSWLS	OR51L1	16	Q8NGJ5
YRCFGSFRALPHAWS	KIR3DL3	291	Q8N743
WYSRFARHPFYGSAG	GXYLT2	251	A0PJZ3
GNRYVTGWFSPYHRQ	HEXD	386	Q8WVB3
WLYVSGGRTPHDLFS	MEGF8	346	Q7Z7M0
LGTPRFTSGRHYWEV	RFPL4A	141	A6NLU0
WAHSGFPEIAFGRYS	MSH6	456	P52701
YPSREAGAWNHGTFR	KIAA1328	531	Q86T90
AGSRVHLGYPWLFLA	GAL3ST2	86	Q9H3Q3
DFLGRYPVSRHSWVG	KLRG2	336	A4D1S0
HPRTRYSAGWDAKFF	HSD17B6	276	O14756
WYRQASEHPAGSFVF	CACNA2D4	801	Q7Z3S7
GSDSFPVGRTHHRWY	SLC31A2	76	O15432
WHYFKGPSYSLRASR	ANGPT4	481	Q9Y264
ADGPHQFWTGYFSSR	MAN2B1	381	O00754
HIPFSNRSGFYWNGV	MAN2B2	221	Q9Y2E5
RPRPTARHWFQAGYS	LOX	116	P28300
ASSHYLWFGRDFFGR	ASNSD1	126	Q9NWL6
HYRFSISWARVLPNG	KL	146	Q9UEF7
FWIFGGSIHYFRVPR	GLB1L2	61	Q8IW92
GDLQPATHGSRFYFW	NDUFA8	156	P51970
SGYNFPWSTHRLVPF	CH25H	216	O95992
LLYVHSSRGGPFQRW	COA1	101	Q9GZY4
SPRRVAYHWDFGDGS	PKD1	2086	P98161
TFTEGSGRSPRYALW	IRF3	331	Q14653
FHLLGCWFYSSRFPS	SYS1	101	Q8N2H4
YRAYGFAPWSLHSFR	USH2A	2291	O75445
LGTPRFTSGRHYWEV	RFPL4AL1	141	F8VTS6
LYWSHPRKFGQGSRS	RPS29	6	P62273
WHPSGRFLGTTCYDR	PRPF4	331	O43172
GSSGSRVFVYCWPRH	ENTPD4	96	Q9Y227
RGHSGYPVTNFWRLD	GCM2	131	O75603
GYWFRAGDHVSRNIP	SIGLEC12	61	Q96PQ1
WYHPRFTIFGTLAFF	CLCNKA	391	P51800
WYHPRFTIFGTLAFF	CLCNKB	391	P51801
GSPGAYDRSFRWKYH	WWP2	486	O00308
AVGIFGHWRTPLGYF	THAP9	326	Q9H5L6
GHWRTPLGYFFVNRA	THAP9	331	Q9H5L6
TRPSHSEVWGYGFLS	SLC39A8	121	Q9C0K1