Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainARM-type_fold

DNAJC13 RRP12 ZNFX1 KPNA6 PRKDC HEATR5B STAG2

3.12e-05339507IPR016024
DomainARM-like

DNAJC13 RRP12 KPNA6 PRKDC HEATR5B STAG2

8.05e-05270506IPR011989
Domain-

DNAJC13 RRP12 KPNA6 PRKDC HEATR5B

3.11e-042225051.25.10.10
DomainTPR-like_helical_dom

TTC7A SH3TC2 RMDN1 SEL1L3 PRKDC

3.88e-04233505IPR011990
Pubmed

L-fucose reduces gut inflammation due to T-regulatory response in Muc2 null mice.

PRKDC MUC2

2.19e-06252236584066
Pubmed

Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice.

B2M PRKDC

2.19e-06252211160136
Pubmed

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.

B2M PRKDC

2.19e-06252220554971
Pubmed

Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice.

B2M PRKDC

2.19e-0625229686607
Pubmed

Epidermal dendritic cell populations in the flaky skin mutant mouse.

TTC7A PRKDC

2.19e-0625228406628
Pubmed

Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury.

B2M PRKDC

2.19e-06252218515407
Pubmed

Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.

B2M PRKDC

2.19e-0625229103418
Pubmed

Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent.

B2M PRKDC

2.19e-0625229103469
Pubmed

Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions.

B2M PRKDC

6.57e-06352210725754
Pubmed

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.

B2M PRKDC

6.57e-06352231303383
Pubmed

Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice.

B2M PRKDC

6.57e-06352212361980
Pubmed

Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl.

B2M PRKDC

6.57e-06352215583018
Pubmed

NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.

B2M PRKDC

6.57e-06352212384415
Pubmed

Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation.

B2M PRKDC

6.57e-06352220382848
Pubmed

A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation.

B2M PRKDC

6.57e-06352226690701
Pubmed

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.

B2M PRKDC

6.57e-06352219659776
Pubmed

Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice.

B2M PRKDC

6.57e-0635228806787
Pubmed

Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model.

B2M PRKDC

6.57e-06352212689924
Pubmed

Cutting edge: Ly49C/I⁻ neonatal NK cells predispose newborns to autoimmune ovarian disease induced by maternal autoantibody.

B2M PRKDC

1.31e-05452223960238
Pubmed

Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II.

B2M PRKDC

1.31e-05452223740949
Pubmed

Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways.

B2M PRKDC

1.31e-05452216936188
Pubmed

Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses.

B2M PRKDC

1.31e-05452229151581
Pubmed

Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts.

B2M PRKDC

1.31e-05452221266499
Pubmed

Deranged early T cell development in immunodeficient strains of nonobese diabetic mice.

B2M PRKDC

1.31e-05452215494484
Pubmed

Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation.

B2M PRKDC

1.31e-05452236924493
Pubmed

Interferon-gamma mediates antigen trafficking to MHC class II-positive late endosomes of enterocytes.

B2M PRKDC

1.31e-05452215688349
Pubmed

Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis.

B2M PRKDC

1.31e-05452232914752
Pubmed

Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells.

B2M PRKDC

1.31e-05452212626535
Pubmed

β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function.

B2M PRKDC

2.19e-05552236868208
Pubmed

Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation.

B2M PRKDC

2.19e-05552219155490
Pubmed

Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells.

B2M PRKDC

2.19e-05552210227978
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

DAGLB BMPR2 MDN1 CELSR2 HSP90AB4P PGAP2 B2M PRKDC ZDHHC13

2.50e-05106152933845483
Pubmed

A putative 12 transmembrane domain cotransporter expressed in thymic cortical epithelial cells.

B2M PRKDC

3.28e-05652210706709
Pubmed

Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction.

B2M PRKDC

3.28e-05652210841521
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

RRP12 GRB10 ZNFX1 IGSF1

4.39e-0513052412421765
Pubmed

Humanized mice in translational biomedical research.

B2M PRKDC

4.58e-05752217259968
Pubmed

Defining the membrane proteome of NK cells.

DNAJC13 MDN1 B2M KPNA6 PRKDC GALNT7 HEATR5B ZDHHC13 STAG2

5.28e-05116852919946888
Pubmed

A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor.

B2M PRKDC

6.10e-05852215383569
Pubmed

The functional interactome landscape of the human histone deacetylase family.

MDN1 RRP12 KPNA6 PRKDC STAG2

7.23e-0528952523752268
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

DAGLB B2M RRP12 KPNA6 PRKDC GALNT7 HEATR5B STAG2

7.36e-0594252831073040
Pubmed

RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells.

B2M PRKDC

7.84e-05952235688159
Pubmed

A crucial role for B cells in neuroinvasive scrapie.

B2M PRKDC

9.79e-05105229414161
Pubmed

Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts.

B2M PRKDC

9.79e-051052228783664
Pubmed

Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells.

B2M PRKDC

9.79e-051052217982459
Pubmed

The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.

B2M PLCG2

1.20e-041152222683124
Pubmed

Differential expression of nicotinic acetylcholine receptor subunits in fetal and neonatal mouse thymus.

PRKDC CHRNB4

1.20e-041152212225896
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DGCR2 MDN1 CELSR2 RRP12 GRB10 PRKDC RYR1 KCNH3

2.20e-04110552835748872
Pubmed

The sperm-associated antigen 6 interactome and its role in spermatogenesis.

RMDN1 DDHD1 MDM4 STAG2

2.27e-0419952431146259
Pubmed

Identification of potential protein interactors of Lrrk2.

MDN1 PRKDC

2.27e-041552217400507
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

DNAJC13 RRP12 ZNFX1 PRKDC

2.40e-0420252433005030
Pubmed

The HSP90 family of genes in the human genome: insights into their divergence and evolution.

HSP90AB4P HSP90AB3P

2.60e-041652216269234
Pubmed

Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING.

B2M PRKDC

2.60e-041652232723479
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

MDN1 RRP12 KPNA6 PRKDC STAG2

3.05e-0439452527248496
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

DNAJC13 MDN1 HSP90AB4P KPNA6 PRKDC STAG2

3.70e-0463852633239621
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

DGCR2 BMPR2 CELSR2 RRP12 PRSS21 SEL1L3 GALNT7 ZDHHC13

3.85e-04120152835696571
Pubmed

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.

PRKDC PLCG2

5.44e-042352222761313
Pubmed

IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.

B2M PRKDC

5.44e-042352234473953
Pubmed

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.

PGAP2 B2M PRKDC STAG2 SP140

5.99e-0445752532968282
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

DNAJC13 HSP90AB4P B2M PRSS21 KPNA6 PRKDC GALNT7 SPECC1

6.40e-04129752833545068
Pubmed

UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors.

CELSR2 CHRNB4

6.96e-042652219474315
Pubmed

Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells.

B2M PRKDC

8.67e-042952234678150
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

DNAJC13 MDN1 RRP12 PRKDC STAG2 WDR44

1.02e-0377452615302935
Pubmed

RUNX1 and TGF-β signaling cross talk regulates Ca2+ ion channels expression and activity during megakaryocyte development.

BMPR2 B2M

1.26e-033552232281291
Pubmed

Galnt1 is required for normal heart valve development and cardiac function.

BMPR2 GALNT7

1.34e-033652225615642
Pubmed

The genetic architecture of economic and political preferences.

EML6 AKR1C1

1.41e-033752222566634
Pubmed

Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2.

DGCR2 PRKDC

1.41e-033752210337614
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

CELSR2 GRB10 PLCG2 RYR1

1.49e-0332952417474147
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCG2 PLA2G4D

6.45e-0419362832
GeneFamilyLipases|Arylacetamide deacetylase family

DAGLB LIPJ

8.68e-0422362464
GeneFamilyPhospholipases

PLCG2 PLA2G4D

3.16e-0342362467
ToppCellfacs-Heart-RA-24m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRIQ1 PLCG2 RYR1 CHRNB4 SP140

1.41e-0616552536415924d05373e9dd3665be599f4f3f40bf0497
ToppCellfacs-Heart-RA-24m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRIQ1 PLCG2 RYR1 CHRNB4 SP140

1.41e-0616552556310fddd3d8e4afdfde066d26cee9747e5b8c6a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SH3TC2 LRRIQ1 EML6 SEL1L3 AKR1C1

2.54e-061865255c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellmild-B_naive|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SEL1L3 DGKD PLCG2 MDM4 SP140

3.62e-06200525222789b897e2a683bbfd1d00b6fd8705015d90df
ToppCellTCGA-Mesothelium-Primary_Tumor-Mesothelioma-Epitheliod-3|TCGA-Mesothelium / Sample_Type by Project: Shred V9

LRRIQ1 FA2H FAM169A ZDHHC13

1.99e-05137524a1e34ebbeda3d5a4f14917282d44fcb4dcbf3133
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

SEL1L3 DGKD PLCG2 ZDHHC13

3.93e-051635246bed27d2f67a430a847da5eb47878d14b4949c45
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Gpc3_Slc18a3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RGS8 GRB10 PLCG2 IGSF1

3.93e-05163524ec9a20cfe0d69430f9c68cddd1ab0e4a3e4554b8
ToppCellTuft-tuft-1|World / Class top

EML6 SEL1L3 DGKD PLCG2

4.42e-051685248ddc2ec483ed2c6c0fb2ae521c6861ceb6d32e34
ToppCellControl-B_cells-Activated_B_cells|Control / group, cell type (main and fine annotations)

EML6 SEL1L3 PLCG2 SP140

4.42e-05168524a7159a35fe37f8c241cf8d391debe271e0698105
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B-B_cells-B-cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEL1L3 DGKD PLCG2 SP140

4.42e-05168524eeb381b62c7ba263af96de1194ed59e57b6ca3ae
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B-B_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEL1L3 DGKD PLCG2 SP140

4.42e-05168524063d0368d656962b335154c230bdcd9236e7c9ad
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_B|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEL1L3 DGKD PLCG2 SP140

4.42e-05168524a7c4251d8a83bc30196a444028a35c17c24dc291
ToppCellLPS-IL1RA-Lymphocytic_B|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEL1L3 DGKD PLCG2 SP140

4.62e-0517052456284fbfd1e53f67c8c0b7fba64505a4002adba2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

B2M PRSS21 SEL1L3 SP140

4.62e-05170524a965e3ee6818790a4a6916824fde64333d9b11b7
ToppCellLPS-IL1RA-Lymphocytic_B-B_cells-B-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEL1L3 DGKD PLCG2 SP140

4.62e-0517052492e0873f618b2fa60c4d555b10f234d5cbcf3325
ToppCellLPS-IL1RA-Lymphocytic_B-B_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEL1L3 DGKD PLCG2 SP140

4.62e-05170524c181991f933b779f99afc3782f292306f209e2ac
ToppCellAdult-Immune-B_cell-D175|Adult / Lineage, Cell type, age group and donor

EML6 SEL1L3 PLCG2 SP140

4.73e-05171524355a246f3395900342d400f6f7c6640cba0d4d5d
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

TTC7A SEL1L3 DGKD PLCG2

4.95e-05173524d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCellLPS-antiTNF-Lymphocytic_B-B_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEL1L3 DGKD PLCG2 SP140

5.06e-05174524b4c2d1c029fcd0d4926aa79a5b789c713919dcf3
ToppCellLPS-antiTNF-Lymphocytic_B|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEL1L3 DGKD PLCG2 SP140

5.06e-05174524cc493654ea3517bc6a145c7f787f304929636f86
ToppCellLPS-antiTNF-Lymphocytic_B-B_cells-B-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEL1L3 DGKD PLCG2 SP140

5.06e-051745249eb3504f9340517ef5d056503044fbdb9ffeb714
ToppCellControl-B_cells|Control / group, cell type (main and fine annotations)

EML6 SEL1L3 PLCG2 SP140

5.29e-051765249125caa27bf790f6b1b960a86c09b4bcb1b58641
ToppCellLPS_only-Lymphocytic_B|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEL1L3 DGKD PLCG2 SP140

5.41e-051775245ed65e08d773d157840317c72e0d43c261d438d4
ToppCellLPS_only-Lymphocytic_B-B_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEL1L3 DGKD PLCG2 SP140

5.41e-05177524c82332c5f656aa26513e4f7525d5d4d733019725
ToppCellLPS_only-Lymphocytic_B-B_cells-B-cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEL1L3 DGKD PLCG2 SP140

5.41e-051775248a955a7ab84c434f9ad4b467246b8be3cb479406
ToppCellChildren_(3_yrs)-Immune-B_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

EML6 SEL1L3 PLCG2 SP140

5.77e-0518052440a12eb852373ae3d7c8d9bca376b0ae99f724b3
ToppCellCOVID-19_Moderate-B_intermediate|World / disease group, cell group and cell class

EML6 SEL1L3 PLCG2 SP140

5.77e-05180524bd81b87a6dc81e5ab4a6c948eb0c80f14401a6a7
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NWD2 LRRIQ1 B2M AKR1C1

5.90e-05181524b9fe3833a6a56b9fbe5c257393fdbea5bf8ac4a3
ToppCellnucseq-Immune-Lymphocytic_B-Lymphocytic_B-B|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

EML6 SEL1L3 PLCG2 SP140

5.90e-051815248d8cc4dae2c8bd5f4b1c159f2a52edc4c9449c86
ToppCellnormal-na-Lymphocytic_B-B_mem-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

EML6 SEL1L3 PLCG2 SP140

6.03e-05182524ee36ea6cb9a5a08aeb83f2b7a249255f0b1a9870
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-6|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FA2H SEL1L3 PLCG2 SP140

6.16e-0518352482fe14fc7039415de41bdfd615a1380bed99f560
ToppCellCOVID-19-B_cells-Plasma_cells|COVID-19 / group, cell type (main and fine annotations)

EML6 SEL1L3 PLCG2 SP140

6.16e-05183524130c109f63a5e3c8f83cb96e32f4addf513b6415
ToppCellCOVID-19-B_cells|COVID-19 / group, cell type (main and fine annotations)

EML6 SEL1L3 PLCG2 SP140

6.16e-051835242c016bb59f131a0e821853b085289a3583f0a729
ToppCellHealthy/Control-B_memory|World / Disease group and Cell class

FA2H EML6 SEL1L3 SP140

6.29e-051845249e1879d86b535ede9b47deb0752e291f987a5d5e
ToppCellnucseq-Immune-Lymphocytic_B-Lymphocytic_B|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

EML6 SEL1L3 PLCG2 SP140

6.29e-05184524942b58ae7172bb5f97e55b032db9329d161854af
ToppCellnucseq-Immune-Lymphocytic_B|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

EML6 SEL1L3 PLCG2 SP140

6.29e-05184524911658e7bb499c1bbc8419eec8ff88729bc39a75
ToppCellCOVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi|lung / Disease (COVID-19 only), tissue and cell type

EML6 SEL1L3 PLCG2 SP140

6.56e-0518652466676d9395172de5707e204826a1c9f73b448cca
ToppCellHealthy_donor-B_memory|World / disease group, cell group and cell class (v2)

FA2H EML6 SEL1L3 SP140

6.69e-051875244f68e3243071a4549c80aff8bff32c6ad892ee7f
ToppCellHealthy/Control-B_memory|Healthy/Control / Disease group and Cell class

FA2H EML6 SEL1L3 SP140

6.83e-051885243aff07f77b2b15e7a30e47b30115178abe64474e
ToppCellHealthy_donor-B_memory|Healthy_donor / disease group, cell group and cell class (v2)

FA2H EML6 SEL1L3 SP140

7.12e-0519052446104a521f00d399315deca86699cb261b2795d6
ToppCellRV-10._Endothelium_II|RV / Chamber and Cluster_Paper

BMPR2 B2M GRB10 AKR1C1

7.56e-0519352401c2df9206f1527c578e808978e58196c35e72f5
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-large_intestine_goblet_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEL1L3 GALNT7 CHRNB4 KCNH3

7.56e-051935246a9bce5064938b5b84ad57b4fd4a7841afe100c8
ToppCellCOVID-19_Mild-Lymphoid_B-B_intermediate|COVID-19_Mild / Disease group, lineage and cell class

EML6 SEL1L3 PLCG2 SP140

7.72e-05194524bf6f72a489c62cbf1a679552d8c5eaaaa0b99d33
ToppCell10x5'v1-week_14-16-Lymphocytic_B-B_lineage-immature_B_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

B2M DGKD PLCG2 SP140

7.87e-05195524ecaaa3d071e763c40d05d088fbf9e8ca06f78f47
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

EML6 SEL1L3 PLCG2 SP140

8.03e-05196524fd18a9ae8401121ae276adff1a85d5f938e2df91
ToppCellBronchial_Biopsy-Epithelial-Club|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

B2M SEL1L3 GALNT7 AKR1C1

8.03e-05196524057d150bdf0cad959fd03ec2d1560a96ba03fae9
ToppCellBronchial_Biopsy-Epithelial-Club|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

B2M SEL1L3 GALNT7 AKR1C1

8.19e-051975243f5dfa892a1f631b96eeb6f4cfc284aee51d1ce6
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

EML6 SEL1L3 PLCG2 SP140

8.19e-051975240f489d26e4013d1b5a90559856ed2de32a0bb772
ToppCell3'-Child04-06|3' / Celltypes from developing, pediatric, Crohn's, & adult GI tract

B2M EML6 SEL1L3 SP140

8.19e-051975245da92d069bb32ede5e8f30c5b68c4d0790373467
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B-B_plasma|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

EML6 SEL1L3 PLCG2 SP140

8.35e-05198524567fcf882c8612356946240843525b786f3c8dbe
ToppCellcontrol-B_intermediate|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

EML6 SEL1L3 PLCG2 SP140

8.35e-05198524e24345c8cec8c21f7b5163b7326ba8f83a587ce3
ToppCellmild-B_memory|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

EML6 SEL1L3 PLCG2 SP140

8.51e-05199524e6ac9a0959b0de2c6a99298feb7715aa80ade1dd
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-B-B_intermediate|COVID-19_Mild / Disease, condition lineage and cell class

EML6 SEL1L3 PLCG2 SP140

8.51e-051995241c6a08d01f6c1a2a4b6587d3a4522efbd03275e1
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

B2M GALNT7 SPECC1 STAG2

8.51e-05199524c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellLPS_only-Hematopoietic_Lymphocytic-B_cells-B-cells|LPS_only / Treatment groups by lineage, cell group, cell type

SEL1L3 DGKD PLCG2 SP140

8.51e-051995247c297a36af047fe47412695e82320cec8a4be83c
ToppCellTracheal-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

EML6 SEL1L3 PLCG2 SP140

8.51e-051995241bb02f41f3cc76a28581e38b0ca4c36b930b85b4
ToppCellTracheal-NucSeq-Immune_Lymphocytic-B|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

EML6 SEL1L3 PLCG2 SP140

8.51e-0519952458242d78517c05fa367a7c6edac57ef79107453c
ToppCellLPS_only-Hematopoietic_Lymphocytic-B_cells|LPS_only / Treatment groups by lineage, cell group, cell type

SEL1L3 DGKD PLCG2 SP140

8.51e-05199524fce4dc28547ae28b99ea9cf7e27c66d6a108fce5
ToppCellTracheal-NucSeq-Immune_Lymphocytic-B-B_plasma|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

EML6 SEL1L3 PLCG2 SP140

8.51e-051995242f60682f1b82918a65e8851e99c9e3398845b62f
ToppCellLPS_IL1RA_TNF-Hematopoietic_Lymphocytic-B_cells-B-cells|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SEL1L3 DGKD PLCG2 SP140

8.68e-05200524c07e37db9d50b91378d9c8355168745560cdbd25
ToppCellmild-B_intermediate|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

EML6 SEL1L3 PLCG2 SP140

8.68e-052005248e3132a1fe3708f725c5c4077878fb87bbea3678
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEL1L3 GRB10 DGKD GALNT7

8.68e-05200524c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCellLPS_IL1RA_TNF-Hematopoietic_Lymphocytic-B_cells|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SEL1L3 DGKD PLCG2 SP140

8.68e-05200524d124acbe5d46220850fe485ed78f032daddca5b1
ToppCellLPS_anti-TNF-Hematopoietic_Lymphocytic-B_cells-B-cells|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SEL1L3 DGKD PLCG2 SP140

8.68e-052005244c8007a158f0f6b6fa259b25d2387b648bb2fc0d
ToppCellmild-B_intermediate|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

EML6 SEL1L3 PLCG2 SP140

8.68e-05200524fe815824e9e4be3f3db73610e3814a7fd533da65
ToppCellLPS_anti-TNF-Hematopoietic_Lymphocytic-B_cells|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SEL1L3 DGKD PLCG2 SP140

8.68e-052005242fb3cf5c7a03c3874390a111bba15203599d4859
ToppCellCOVID-19-B_cells-B_cells|COVID-19 / group, cell type (main and fine annotations)

SEL1L3 PLCG2 SP140

4.70e-04130523267b06a0db31e2664cf595cd737402da07ab51cd
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf|Hippocampus / BrainAtlas - Mouse McCarroll V32

SH3TC2 FA2H CDC37L1

4.91e-04132523dc6edfa821a1cdc645668b0af5ba5ff80dee10bd
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O2|Hippocampus / BrainAtlas - Mouse McCarroll V32

SH3TC2 FA2H CDC37L1

4.91e-0413252360ced08bda5efc95a6f116cd0c6d1a779d99ed38
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE|Hippocampus / BrainAtlas - Mouse McCarroll V32

SH3TC2 FA2H CDC37L1

5.47e-041375235e97480f014f1d9267e8126f1d0e58acd22f36aa
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_memory-B_memory-6|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

EML6 SEL1L3 SP140

6.98e-041495232cd860b96ed4be4d26844085d464961c1418054a
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-B_lymphocytic-memory_B_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SEL1L3 MDM4 FOXR2

7.83e-04155523d336559092563b0d7776eef873f1d2759aca45f7
ToppCellAdult-Immune-B_cell-D122|Adult / Lineage, Cell type, age group and donor

SEL1L3 PLCG2 SP140

7.83e-041555235857aebd43b901fc9f8c46f2d628582969db9e6a
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Adamts2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NWD2 RYR1 KCNH3

7.98e-041565232cd007b423c2395c5ce331902e7f27c805755eb3
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RRP12 EML6 SPECC1

8.13e-04157523a426c54fd1545093d41426e9620862f71bd06f6b
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPECC1 WDR44 SP140

8.28e-0415852391d265e95156f16459924d3e4dd11c180e164eee
ToppCellnormal_Lung-B_lymphocytes-Undetermined|normal_Lung / Location, Cell class and cell subclass

EML6 DGKD SPECC1

8.43e-04159523f89fc18966d9b9b33e81e7b9eb3ec3420c20ff43
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

B2M PLCG2 SP140

8.43e-04159523dd9059f98eec43adbcc0cd42bb155670f7a3a479
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRIQ1 RYR1 KCNH3

8.43e-0415952300a157d033627d0e65c3fbd38d652c4cf56b47f6
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

EML6 SEL1L3 SP140

8.58e-041605237ad065337ac802de52c15ee715f6b78a3eed0cef
ToppCellCOVID-19-kidney-Plasma|COVID-19 / Disease (COVID-19 only), tissue and cell type

SEL1L3 PLCG2 SP140

8.58e-04160523f8d9e459976e711e9ad39ea2b6173140c0589d6e
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TTC7A GRB10 RFNG

8.74e-041615238ec923c230a7a3cce5edf2a736b3a00d607c698a
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPECC1 WDR44 SP140

8.90e-0416252393bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCellTCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Seminoma-_NOS-5|TCGA-Testes / Sample_Type by Project: Shred V9

DDHD1 EML6 DGKD

9.06e-0416352380bc3732afd8501938753120b8403098c7c5e928
ToppCellTCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Seminoma-_NOS|TCGA-Testes / Sample_Type by Project: Shred V9

DDHD1 EML6 DGKD

9.06e-0416352367551fefe22bd5b8178fa248fed2a6c17b19fb0f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-B_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PRSS21 SEL1L3 SP140

9.38e-041655237039bb5a7af4684fbd1192230864e5cd6936e83c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GRB10 PLCG2 GALNT7

9.38e-04165523dc570154baed59ed109e5369589448e075ba66a9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-B_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PRSS21 SEL1L3 SP140

9.38e-04165523d2c79653710b139794170f3d72f11392fc548ac7
ToppCellcontrol-Plasmablast|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FA2H EML6 SEL1L3

9.38e-0416552361063e0ce61bc92d5d1093be8279af03f650720b
ToppCellfacs-Marrow-B-cells-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH3TC2 EML6 SEL1L3

9.38e-04165523361a605d8f833d9ec54b120480dce397da35f9c3
ToppCellhealthy_donor-Lymphocytic-Plasma_cell-IgM_Plasmablast|healthy_donor / Disease condition, Lineage, Cell class and subclass

FA2H EML6 SEL1L3

9.55e-041665232b7b580bec8d9467b0deaf97098065f72dbf2a4f
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-9|TCGA-Brain / Sample_Type by Project: Shred V9

IGSF1 AKR1C1 RYR1

9.71e-04167523013971700e80b71e4b8c79b8fff0d8beeac295c3
ToppCellControl-NK|Control / Disease group and Cell class

PGAP2 ZNF283 EML6

9.88e-04168523683d389c8a1e791bfc773e63148115a21a6566db
ToppCell3'-Adult-LargeIntestine-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRRC66 PLCG2 MUC2

9.88e-041685232163e6774eb7a3d010422e4d59be5e45b4158329
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_mem-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

FA2H SEL1L3 SP140

1.01e-03169523e3ec9468141b6456398dca17dd8eeaabd2462710
ToppCellPND10-Immune-Immune_Myeloid-DC-maDC-maDC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

B2M KCNH3 SP140

1.01e-03169523a83e4078db91ecedee637b28b12ec38640fe45f9
ToppCellfacs-Heart-RA-24m-Lymphocytic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR1 CHRNB4 SP140

1.01e-03169523dcf92121fb00e3b6498e2648363e90ac044ea396
ToppCellPND10-Immune-Immune_Myeloid-DC-maDC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

B2M KCNH3 SP140

1.01e-03169523f914aa8899fa170a09da31e5fad86de897ea789b
ToppCell343B-Myeloid-Dendritic-cDC_activated|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

B2M EML6 LIPJ

1.01e-03169523e68e6c24606fd46eca6f86bb63fa86ea17879ae2
ToppCellChildren_(3_yrs)-Immune-B_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SEL1L3 PLCG2 SP140

1.02e-03170523e421f9eedf74baffda1d03707a710ece4b777f29
Diseaseprimary pulmonary hypertension (is_implicated_in)

BMPR2 RYR1

4.37e-056512DOID:14557 (is_implicated_in)
DiseaseAbdominal Aortic Aneurysm

CELSR2 CHRNB4 HSP90AB3P

2.25e-0468513EFO_0004214
DiseaseSpastic Paraplegia, Hereditary

FA2H DDHD1

2.63e-0414512C0037773
DiseaseNeoplasm of uncertain or unknown behavior of bladder

MDM4 STAG2

3.03e-0415512C0496930
DiseaseBenign neoplasm of bladder

MDM4 STAG2

3.03e-0415512C0154017
DiseaseCarcinoma in situ of bladder

MDM4 STAG2

3.03e-0415512C0154091
DiseaseCarcinoma of bladder

MDM4 STAG2

4.40e-0418512C0699885
Diseaselarge artery stroke, coronary artery disease

CELSR2 CHRNB4

8.57e-0425512EFO_0001645, EFO_0005524
Diseaseeosinophil count

SH3TC2 MDN1 FA2H RRP12 GRB10 PRKDC MDM4 MUC2 SP140

9.20e-041488519EFO_0004842
Diseasemuscular atrophy (biomarker_via_orthology)

HSP90AB4P HSP90AB3P

1.15e-0329512DOID:767 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
NCTLKFRSWTYDHTE

CHRNB4

166

P30926
HSDLSFSKDWSFYLL

B2M

71

P61769
WSDGLAFCALLHTYL

SPECC1

991

Q5M775
LHFLYLCTFSWALLE

CELSR2

2446

Q9HCU4
LCTFSWALLEALHLY

CELSR2

2451

Q9HCU4
IYSLDGSDCVHKWNF

NWD2

1331

Q9ULI1
FKSIHCLLYPDTDWC

RFNG

306

Q9Y644
KSICLHYVTTWFLLD

KCNH3

296

Q9ULD8
FCILWSLLFHFKETT

PGAP2

36

Q9UHJ9
SDLLADACWALSYLS

KPNA6

266

O60684
TLFHSWKDFEVCSSA

MDN1

4411

Q9NU22
LRKDWYSDCSKLTHS

MDM4

326

O15151
FYKSLTSDWEDHLAV

HSP90AB3P

246

Q58FF7
EFYKSLTSAWEDHLA

HSP90AB4P

276

Q58FF6
HLYLETSSKEFWAFS

LIPJ

96

Q5W064
ANYAEHWCSLLKKTE

MUC2

581

Q02817
WTRHYCAIADAKLSF

PLCG2

491

P16885
YDTALQSKAAEWHCS

LRRC66

826

Q68CR7
LKSAIKWFDACYSLH

LRRIQ1

1096

Q96JM4
KWFDACYSLHELSLT

LRRIQ1

1101

Q96JM4
STKLWDYCFHTLTPE

FA2H

351

Q7L5A8
LQLTYLDSCYWDHKE

ANP32C

136

O43423
DTGIYSCHYLLTWKT

IGSF1

386

Q8N6C5
SLCHYDDSVLLGSWL

HEATR5B

716

Q9P2D3
YSAKWSHEAEFSKIL

DAGLB

616

Q8NCG7
ECKYWHYDENLLTSS

GALNT7

196

Q86SF2
SLCKYLSLHTSDWVS

BMPR2

286

Q13873
ENKDLACFYTTKHSW

DNAJC13

6

O75165
FLCHSSTDYAKILWK

FAM169A

136

Q9Y6X4
SWHAESCYEKSSFLC

DGCR2

251

P98153
AAWLEHLSLCEYKDI

DGKD

1151

Q16760
WKSTIHYNLCFLDSF

FOXR2

236

Q6PJQ5
LLVYKSHCVDDNSWT

GRB10

196

Q13322
LSFITHIDWSLDSKY

EML6

451

Q6ZMW3
SHTAYWSSLDVALFL

DDHD1

866

Q8NEL9
CAESWHTDSYFTLFI

GPR21

181

Q99679
SYKAAWILTEDHSFE

RYR1

3656

P21817
EETAKYLILWCFHLE

CDC37L1

191

Q7L3B6
CSHKDFSTWADYQLD

PLA2G4D

616

Q86XP0
VECSAKYNWHILLLF

RASL10B

156

Q96S79
TRWADSFDVLLSHKY

RGS8

51

P57771
ESFSPCSLAWLYLHL

SEL1L3

1036

Q68CR1
FESSLCLAWAYLLAS

SH3TC2

796

Q8TF17
YKFHAAWSSVLQLLC

RRP12

481

Q5JTH9
REDIFYTSKLWCNSH

AKR1C1

76

Q04828
HCATTFKEDGLWTYL

ZDHHC13

496

Q8IUH4
FASHKWYAICLSDVG

RMDN1

161

Q96DB5
HDLSKWDLFACNYKL

STAG2

701

Q8N3U4
HTADLLDLSWSKNYF

WDR44

606

Q5JSH3
KDFWELASLDCYNHL

PRKDC

2991

P78527
LASLDCYNHLAEWKS

PRKDC

2996

P78527
ISFYDHLASLWDSLK

ZNFX1

1706

Q9P2E3
LLHSLSEECYWSPLS

TTC7A

291

Q9ULT0
YCVLSELEKTFGWSH

SP140

96

Q13342
WALTAAHCFETYSDL

PRSS21

76

Q9Y6M0
FTLFSCLSLLSSWDY

ZNF283

26

Q8N7M2
DDLLKYLWAAHTSTL

LEG1

201

Q6P5S2