Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1D CACNA1E CACNA1S

1.28e-0514673GO:0008331
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1D CACNA1E CACNA1S TRPA1

1.70e-0546674GO:0005245
GeneOntologyMolecularFunctionosmolarity-sensing monoatomic cation channel activity

TRPA1 SCN7A

1.10e-045672GO:1990760
GeneOntologyMolecularFunctionosmosensor activity

TRPA1 SCN7A

1.65e-046672GO:0005034
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNA1D CACNA1E

3.93e-049672GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNA1D CACNA1E

3.93e-049672GO:0099626
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1D CACNA1E CACNA1S TRPA1

9.30e-04129674GO:0005262
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1D CACNA1E CACNA1S TRPA1 SCN7A UNC80

1.02e-03343676GO:0005261
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1D CACNA1E CACNA1S TRPA1

1.66e-03151674GO:0015085
GeneOntologyMolecularFunctionmetalloexopeptidase activity

AGBL4 ADAM17 AGBL3

1.68e-0370673GO:0008235
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1D CACNA1E CACNA1S TRPA1

1.71e-03152674GO:0022843
GeneOntologyCellularComponentcochlear hair cell ribbon synapse

CACNA1D CAMK2D

1.51e-046672GO:0098683
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1D CACNA1E CACNA1S

4.33e-0446673GO:0005891
GeneOntologyCellularComponentruffle

MYO10 MKLN1 AKT2 ADAM17 SNX9

5.21e-04206675GO:0001726
GeneOntologyCellularComponentL-type voltage-gated calcium channel complex

CACNA1D CACNA1S

6.54e-0412672GO:1990454
GeneOntologyCellularComponentcation channel complex

CACNA1D CACNA1E CACNA1S SCN7A UNC80

9.43e-04235675GO:0034703
GeneOntologyCellularComponentcell leading edge

CACNA1D PTPRK MYO10 MKLN1 AKT2 ADAM17 SNX9

1.08e-03500677GO:0031252
DomainVDCC_a1su_IQ

CACNA1D CACNA1E CACNA1S

1.46e-067663IPR014873
DomainGPHH

CACNA1D CACNA1E CACNA1S

1.46e-067663PF16905
DomainGPHH_dom

CACNA1D CACNA1E CACNA1S

1.46e-067663IPR031649
DomainCa_chan_IQ

CACNA1D CACNA1E CACNA1S

1.46e-067663SM01062
DomainCa_chan_IQ

CACNA1D CACNA1E CACNA1S

1.46e-067663PF08763
DomainVDCCAlpha1

CACNA1D CACNA1E CACNA1S

4.97e-0610663IPR002077
DomainChannel_four-helix_dom

CACNA1D CACNA1E CACNA1S SCN7A

4.88e-0557664IPR027359
Domain-

CACNA1D CACNA1E CACNA1S SCN7A

4.88e-05576641.20.120.350
DomainIon_trans_dom

CACNA1D CACNA1E CACNA1S TRPA1 SCN7A

5.15e-05114665IPR005821
DomainIon_trans

CACNA1D CACNA1E CACNA1S TRPA1 SCN7A

5.15e-05114665PF00520
DomainVDCC_L_a1su

CACNA1D CACNA1S

7.35e-054662IPR005446
DomainPeptidase_M14

AGBL4 AGBL3

2.97e-0323662PF00246
DomainPeptidase_M14

AGBL4 AGBL3

2.97e-0323662IPR000834
DomainPTPase_domain

PTPRK CDC14B

9.23e-0341662IPR000242
DomainY_phosphatase

PTPRK CDC14B

9.23e-0341662PF00102
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1D CACNA1E CACNA1S

7.96e-0523523M47666
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1D CACNA1E CACNA1S

1.03e-0425523M47948
Pubmed

Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

CACNA1D CACNA1E CACNA1S

2.38e-07767312900400
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1D CACNA1E CACNA1S

3.80e-07867328330839
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1D CACNA1E CACNA1S

3.06e-061567320188150
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1D CACNA1E CACNA1S

3.06e-061567324453333
Pubmed

Overexpression of CDC14B causes mitotic arrest and inhibits zygotic genome activation in mouse preimplantation embryos.

CDC14C CDC14B

3.66e-06267219923902
Pubmed

The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway.

CDC14C CDC14B

3.66e-06267221502810
Pubmed

The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cells.

ADAM17 PTK7

3.66e-06267222665490
Pubmed

Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.

CDC14C CDC14B

3.66e-06267218547142
Pubmed

Structure and functional characterization of neuronal alpha 1E calcium channel subtypes.

CACNA1D CACNA1E

3.66e-0626728071363
Pubmed

[The expression of genes encoding the voltage-dependent L-type Ca2+ channels in proliferating and differentiating C2C12 myoblasts of mice].

CACNA1D CACNA1S

3.66e-06267221789999
Pubmed

Mechanisms Responsible for ω-Pore Currents in Cav Calcium Channel Voltage-Sensing Domains.

CACNA1D CACNA1S

3.66e-06267228978442
Pubmed

Early-onset aging and defective DNA damage response in Cdc14b-deficient mice.

CDC14C CDC14B

1.10e-05367221262768
Pubmed

Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels.

CACNA1D CACNA1S

1.10e-05367217289261
Pubmed

Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP).

CACNA1D CACNA1S

1.10e-05367217767505
Pubmed

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.

CDC14C CDC14B

1.10e-05367222355704
Pubmed

CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes.

CDC14C CDC14B

1.10e-05367219129509
Pubmed

Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes.

CACNA1D CACNA1S

1.10e-0536722173707
Pubmed

Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.

CDC14C CDC14B

1.10e-05367226283732
Pubmed

OS9 Protein Interacts with Na-K-2Cl Co-transporter (NKCC2) and Targets Its Immature Form for the Endoplasmic Reticulum-associated Degradation Pathway.

SLC12A3 OS9

1.10e-05367226721884
Pubmed

CDC14A phosphatase is essential for hearing and male fertility in mouse and human.

CDC14C CDC14B

2.19e-05467229293958
Pubmed

Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.

CACNA1D CACNA1S

2.19e-05467220937870
Pubmed

Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development.

IL7 PTK7

2.19e-05467220709954
Pubmed

Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/CCdh1 regulation during meiotic G2/M transition in mouse oocytes.

CDC14C CDC14B

2.19e-05467232341029
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1D CACNA1E

3.64e-05567215451373
Pubmed

Developmental expression patterns of alpha1H T-type Ca2+ channels during spermatogenesis and organogenesis in mice.

CACNA1D CACNA1E

3.64e-05567212060068
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1D CACNA1E

3.64e-05567211296258
Pubmed

The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas.

AKT2 PGR

5.46e-05667222107784
Pubmed

A novel subfamily of mouse cytosolic carboxypeptidases.

AGBL4 AGBL3

5.46e-05667217244818
Pubmed

The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids.

AGBL4 AGBL3

5.46e-05667225103237
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

CACNA1E KIF26A MCM9 KMT2E ZNF292

8.90e-0523367537704626
Pubmed

Vezf1: A Zn finger transcription factor restricted to endothelial cells and their precursors.

VEZF1 MAZ

1.02e-0486729986727
Pubmed

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.

AGBL4 AGBL3

1.30e-04967226829768
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1E CACNA1S

1.30e-04967216382099
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA1D CACNA1E CACNA1S SCN7A

1.54e-0413967416985003
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

CDK5RAP3 PUS3 VEZF1 MYO10 MCM9 PHF14 SNAPC3 COG5 GTPBP10 ZNF292

2.17e-041327671032694731
Pubmed

IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development.

AGBL4 AGBL3

2.38e-041267228794449
Pubmed

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.

MYO10 ANGPTL1

3.78e-041567210051567
Pubmed

Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.

C17orf75 MRPL22 PRIM2 OS9 SNX9 GTPBP10 CDC14B PPP4R3A

4.13e-0493167827432908
Pubmed

Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.

CDK5RAP3 EXOC6B GTPBP10 PTK7

4.39e-0418367431932471
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

CDK5RAP3 MKLN1 OS9 SNX9 GTPBP10 PTK7

5.70e-0453367625544563
Pubmed

The transcription factor Maz is essential for normal eye development.

LHX2 MAZ

7.50e-042167232571845
Pubmed

PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation.

PUS3 PPP4R3A

9.82e-042467224710276
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

VEZF1 MAZ ZNF516 SNX9 ZNF292

1.03e-0339867535016035
Pubmed

Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.

AGBL4 AGBL3

1.07e-032567229593216
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

VEZF1 MAZ PHF14 CABIN1 SPEN ZNF292

1.13e-0360867636089195
Pubmed

ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes.

CAMK2D ZNF516

1.15e-032667225228645
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

ZNF516 SPEN UNC80 SLC3A1 PTK7

1.31e-0342067528065597
Pubmed

Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.

CAMK2D AKT2

1.34e-032867224462114
Pubmed

The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

CACNA1D CACNA1S

1.86e-033367222357600
Cytoband18q23

TXNL4A ZNF516

8.30e-042967218q23
CytobandEnsembl 112 genes in cytogenetic band chr18q23

TXNL4A ZNF516

1.58e-0340672chr18q23
GeneFamilyCalcium voltage-gated channel subunits

CACNA1D CACNA1E CACNA1S

3.14e-0526433253
CoexpressionGSE14769_40MIN_VS_360MIN_LPS_BMDM_DN

CACNA1D MYO10 EXOC6B KMT2E CABIN1 SPEN

1.21e-05199676M3517
Drugnitrendipine; Up 200; 10uM; MCF7; HG-U133A

LHX2 GPR4 TXNL4A GPR173 EXOC6B LBP PTK7

1.89e-06198677336_UP
DrugCNS 1145

CACNA1D CACNA1E CACNA1S TRPA1

2.63e-0633674CID000190902
DrugIHC-64

CACNA1D CACNA1E CACNA1S TRPA1

2.63e-0633674CID000162753
Drugisradipine

CACNA1D CACNA1E CACNA1S TRPA1 SCN7A

1.15e-05100675CID000003784
Drugaldosterone

CACNA1D CACNA1E CACNA1S TRPA1 SLC12A3 AKT2 CABIN1 PGR

2.12e-05397678CID000005839
DrugCinildipine

CACNA1D CACNA1E CACNA1S TRPA1

2.24e-0556674CID000002752
Druglamotrigine

CACNA1D CACNA1E CACNA1S TRPA1 SCN7A

2.36e-05116675CID000003878
DrugTrimethoprim [738-70-5]; Down 200; 13.8uM; MCF7; HT_HG-U133A

TXNL4A MAZ SNAPC3 CABIN1 PPP4R3A PARP12

2.50e-051976762307_DN
Drugnilvadipine

CACNA1D CACNA1E CACNA1S TRPA1

2.95e-0560674CID000004494
DrugIAA-94

CACNA1D CACNA1E CACNA1S TRPA1

3.15e-0561674CID000003667
Drugbepridil

CACNA1D CACNA1E CACNA1S TRPA1 SCN7A

3.52e-05126675CID000002351
Druglercanidipine

CACNA1D CACNA1E CACNA1S TRPA1

3.58e-0563674CID000065866
Druggallopamil

CACNA1D CACNA1E CACNA1S TRPA1

4.57e-0567674CID000001234
DrugAC1L2AC7

CACNA1D CACNA1E CACNA1S TRPA1

5.13e-0569674CID000068733
DrugCAS 298-57-7

CACNA1D CACNA1E CACNA1S TRPA1

6.40e-0573674CID000002761
Drugethosuximide

CACNA1D CACNA1E CACNA1S TRPA1

6.75e-0574674CID000003291
Drugnisoldipine

CACNA1D CACNA1E CACNA1S TRPA1

8.29e-0578674CID000004499
DrugNilvadipine

CACNA1D CACNA1S

8.48e-055672DB06712
DrugNisoldipine

CACNA1D CACNA1S

8.48e-055672DB00401
DrugN-cyclopentyl-N-cyclobutylformamide

CACNA1D CACNA1E CACNA1S TRPA1

8.72e-0579674CID005287890
Drugprocaine

CACNA1D CACNA1E CACNA1S TRPA1 SCN7A

8.86e-05153675CID000004914
Druggenistein

CACNA1D CACNA1E CACNA1S TRPA1 PTPRK RRM2B MAZ PHF14 AKT2 ADAM17 IL7 PGR

9.02e-0511176712CID005280961
DiseaseTimothy syndrome (implicated_via_orthology)

CACNA1D CACNA1S

2.95e-054662DOID:0060173 (implicated_via_orthology)
DiseaseSeizures

CACNA1E RRM2B KMT2E ZNF292 PIGM

1.30e-04218665C0036572
Diseaseepilepsy (implicated_via_orthology)

CACNA1E SLC12A3 CAMK2D SCN7A

4.95e-04163664DOID:1826 (implicated_via_orthology)
Diseaseovarian carcinoma (is_implicated_in)

AKT2 CABIN1

5.08e-0415662DOID:4001 (is_implicated_in)
Diseaselongitudinal BMI measurement

CACNA1E MIGA2 MYO10

8.34e-0482663EFO_0005937
DiseaseNephritis, Tubulointerstitial

SLC12A3 SLC3A1

1.01e-0321662C0041349
Diseaseelectrocardiography

PUS3 CAMK2D MKLN1 ZFC3H1 COG5 CDC14B

1.19e-03530666EFO_0004327
DiseaseNeurodevelopmental Disorders

KMT2E PTK7 ZNF292

1.20e-0393663C1535926
DiseaseNephritis, Interstitial

SLC12A3 SLC3A1

1.32e-0324662C0027707
Diseaseatrial fibrillation

AGBL4 CAMK2D COG5 SPEN ZNF292

1.46e-03371665EFO_0000275

Protein segments in the cluster

PeptideGeneStartEntry
QEDRRCTGYIFFYMH

USP26

871

Q9BXU7
MNNHRANDKFFLYVC

PRO1854

1

Q9UHT4
KYAFQTHDRLCFVME

AKT2

216

P31751
YCDLHGHSRKENIFM

AGBL3

456

Q8NEM8
EFYSGKLHRACFMNN

CACNA1E

241

Q15878
DCFHAVKKAMQYGFL

CDC14B

181

O60729
CDYLFFRNNMPEFHK

CFAP418

151

Q96NL8
LDRDKDMYAGNCAHF

ANGPTL1

421

O95841
DCFHAVKKAMQYGFL

CDC14C

151

A4D256
TEFLGFFYKHCMHVL

PPP4R3A

471

Q6IN85
EMFYAQKCHCFLADI

KCTD19

816

Q17RG1
HVGKVFMARNYEFLA

DAOA

101

P59103
HKDFLFLGANVQYMR

LBP

466

P18428
CDMQEKFRHNIAYFP

ISOC2

21

Q96AB3
HMDTRNFCDIGYHFL

PGLYRP3

231

Q96LB9
MFALFEYNGHVDKAI

MYO10

1741

Q9HD67
FVLFYSKFHGLEMCV

KMT2E

381

Q8IZD2
CEMCGKAFRDVYHLN

MAZ

281

P56270
FGMKDSLVYCRLHFE

LHX2

156

P50458
FTLHVYQYRMEKCGR

KIF26A

606

Q9ULI4
CAFFKHQIVQYLRDM

MIGA2

521

Q7L4E1
DREIEKMCNFHYQGF

EXOC6B

61

Q9Y2D4
FIRQAEMNHYALFKC

C17orf75

336

Q9HAS0
GMCRAYFHVTCAQKE

PHF14

461

O94880
DRYNHTFCFEKFPME

GPR4

161

P46093
SCDFVKRHFFSDYLM

LY6H

76

O94772
QLHLCRFMVYGACKF

PARP12

91

Q9H0J9
FKRAMEGQHNYLCAG

PGR

591

P06401
KYFEMIHNVDDCGFS

PRIM2

426

P49643
IARVMSDYFKHFECL

COG5

651

Q9UP83
VVHMKDFFYFRNHFC

DYRK4

166

Q9NR20
FCHFFFEAYIGKMRK

ELOVL6

246

Q9H5J4
MVHCSCVLFRKYGNF

GTPBP10

1

A4D1E9
KFYMHDICICPNRFD

CABIN1

1076

Q9Y6J0
AAMKIIAYGFLFHQD

CACNA1S

101

Q13698
AFLHKGSFCRNYFNM

CACNA1S

856

Q13698
EMREQFYHSCKQYGI

CDK5RAP3

156

Q96JB5
DHRKNYVMSFAFCFD

AGBL4

141

Q5VU57
FFKRHICDANKEGMF

IL7

66

P13232
FEHRYFKANDTLGFM

GPR173

176

Q9NS66
HKGAFCRNYFNLLDM

CACNA1D

946

Q01668
GMDFHRFYFENALSK

CAMK2D

391

Q13557
YFRGHNESKADCLDM

PTPRK

431

Q15262
GRFGIMEKVYCHYFV

MRPL22

156

Q9NWU5
FERDYMCNKCKHVFV

MCM9

141

Q9NXL9
LHFLMECNHEYKGFL

SNX9

486

Q9Y5X1
YVGTHDFRNLCKMDV

PUS3

216

Q9BZE2
MLFHSKNRCLYVFGG

MKLN1

461

Q9UL63
FDEVRNQCYFHQFMK

SLC3A1

266

Q07837
DVCFRMLHYDSEGNK

SNAPC3

381

Q92966
EFCYGRHIQQYHMED

OS9

121

Q13438
KVCLAHLFTYQDFDM

ADAM17

331

P78536
HCDFACLMFQYLVNK

RRM2B

231

Q7LG56
ECFECGKIFRTYHQM

ZNF516

516

Q92618
LKRCDDMDTFFLHYA

TRPA1

56

O75762
VGYADFFNEHMRKLC

UNC80

586

Q8N2C7
CEMCGKAFRDVYHLN

VEZF1

176

Q14119
YHCMEKSGQDIRDFY

SPEN

596

Q96T58
CKLDMNFGSCYEVHF

SPINT4

41

Q6UDR6
CGRYFIQMADFHRHE

ZNF620

201

Q6ZNG0
RFLYCDVMLENFAHV

ZNF551

51

Q7Z340
MQYCVLCDKEFLGHR

ZNF292

541

O60281
LHDAFDFNYGVCVMR

SLC12A3

761

P55017
ECLERAMKFAFGEFH

TTC7A

401

Q9ULT0
MKLFGKNYEEFVCHI

SCN7A

646

Q01118
YDPCTVMFFFRNKHI

TXNL4A

76

P83876
VACAAVFYGFAVHMK

PIGM

166

Q9H3S5
VARYEEAMFHCQFSA

PTK7

236

Q13308
EVFYHMCKFFILQNR

ZFC3H1

1671

O60293