Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ArfGap	GIT2 AGAP4 AGAP6	1.47e-05	29	31	3	SM00105
Domain	ARFGAP	GIT2 AGAP4 AGAP6	1.47e-05	29	31	3	PS50115
Domain	ArfGAP	GIT2 AGAP4 AGAP6	1.47e-05	29	31	3	IPR001164
Domain	ArfGap	GIT2 AGAP4 AGAP6	1.47e-05	29	31	3	PF01412
Domain	ANK	GIT2 ANKHD1 AGAP4 AGAP6 NOTCH1	5.38e-05	251	31	5	SM00248
Domain	ANK_REPEAT	GIT2 ANKHD1 AGAP4 AGAP6 NOTCH1	5.58e-05	253	31	5	PS50088
Domain	Ankyrin_rpt-contain_dom	GIT2 ANKHD1 AGAP4 AGAP6 NOTCH1	5.69e-05	254	31	5	IPR020683
Domain	ANK_REP_REGION	GIT2 ANKHD1 AGAP4 AGAP6 NOTCH1	5.69e-05	254	31	5	PS50297
Domain	Ankyrin_rpt	GIT2 ANKHD1 AGAP4 AGAP6 NOTCH1	6.59e-05	262	31	5	IPR002110
Domain	UBA-like	TAB2 TNRC6C UBALD1	1.61e-04	64	31	3	IPR009060
Domain	Ank_2	GIT2 AGAP4 AGAP6 NOTCH1	4.21e-04	215	31	4	PF12796
Domain	Ank	GIT2 ANKHD1 AGAP4 NOTCH1	5.25e-04	228	31	4	PF00023
Domain	-	GIT2 AGAP4 AGAP6 NOTCH1	7.20e-04	248	31	4	1.25.40.20
Domain	PH	SNTG1 AGAP4 AGAP6	1.08e-02	278	31	3	SM00233
Domain	PH_DOMAIN	SNTG1 AGAP4 AGAP6	1.09e-02	279	31	3	PS50003
Domain	PH_domain	SNTG1 AGAP4 AGAP6	1.10e-02	280	31	3	IPR001849
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIKFYVE ATMIN CARD10 TNRC6C PER2 GAREM2 ANKHD1 ZNF827 TESK1 NOTCH1	2.43e-08	1105	31	10	35748872
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	PIKFYVE TAB2 TNRC6C AGAP4 AGAP6 CPEB4	3.66e-08	218	31	6	33378226
Pubmed	Periventricular notch activation and asymmetric Ngn2 and Tbr2 expression in pair-generated neocortical daughter cells.	NEUROG2 NOTCH1	2.31e-06	3	31	2	19059340
Pubmed	Exploring the potential relationship between Notch pathway genes expression and their promoter methylation in mice hippocampal neurogenesis.	NEUROG2 NOTCH1	2.31e-06	3	31	2	25701255
Pubmed	Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism.	XYLT1 NOTCH1	4.61e-06	4	31	2	26414444
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	XYLT1 CASP8AP2 NHS ANKHD1	7.69e-06	142	31	4	11812828
Pubmed	The Neurog2-Tbr2 axis forms a continuous transition to the neurogenic gene expression state in neural stem cells.	NEUROG2 NOTCH1	1.15e-05	6	31	2	38772376
Pubmed	Retinoic acid-dependent signaling pathways and lineage events in the developing mouse spinal cord.	NEUROG2 NOTCH1	1.61e-05	7	31	2	22396766
Pubmed	Genome-wide analysis of Müller glial differentiation reveals a requirement for Notch signaling in postmitotic cells to maintain the glial fate.	NEUROG2 NOTCH1	1.61e-05	7	31	2	21829655
Pubmed	PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.	GCM1 ADAMTS9 NOTCH1	2.02e-05	59	31	3	38374152
Pubmed	Transcriptome and proteome analysis of early embryonic mouse brain development.	NEUROG2 NOTCH1	2.15e-05	8	31	2	18283662
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP4 AGAP6	2.76e-05	9	31	2	12640130
Pubmed	Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome.	ADAMTS9 NOTCH1	2.76e-05	9	31	2	23095891
Pubmed	Ectopic expression of Gcm1 induces congenital spinal cord abnormalities.	GCM1 NOTCH1	2.76e-05	9	31	2	12135932
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP4 AGAP6	3.44e-05	10	31	2	20664521
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP4 AGAP6	4.21e-05	11	31	2	15381706
Pubmed	Conservation of the Notch signalling pathway in mammalian neurogenesis.	NEUROG2 NOTCH1	4.21e-05	11	31	2	9102301
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CASP8AP2 TAB2 GIT2 TNRC6C	4.68e-05	225	31	4	12168954
Pubmed	Mapping spatio-temporal activation of Notch signaling during neurogenesis and gliogenesis in the developing mouse brain.	NEUROG2 NOTCH1	5.05e-05	12	31	2	15198674
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP4 AGAP6	5.96e-05	13	31	2	27713690
Pubmed	Basal progenitor cells in the embryonic mouse thalamus - their molecular characterization and the role of neurogenins and Pax6.	NEUROG2 NOTCH1	6.95e-05	14	31	2	22077982
Pubmed	Shh and Gli3 activities are required for timely generation of motor neuron progenitors.	NEUROG2 NOTCH1	6.95e-05	14	31	2	19433083
Pubmed	bHLH gene expression in the Emx2-deficient dentate gyrus reveals defective granule cells and absence of migrating precursors.	NEUROG2 NOTCH1	6.95e-05	14	31	2	15084498
Pubmed	Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice.	NEUROG2 NOTCH1	6.95e-05	14	31	2	18164701
Pubmed	Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis.	NEUROG2 NOTCH1	6.95e-05	14	31	2	26728556
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP4 AGAP6	6.95e-05	14	31	2	22453919
Pubmed	Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina.	NEUROG2 NOTCH1	6.95e-05	14	31	2	25100656
Pubmed	F3/Contactin acts as a modulator of neurogenesis during cerebral cortex development.	NEUROG2 NOTCH1	6.95e-05	14	31	2	22360968
Pubmed	A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development.	NEUROG2 NOTCH1	6.95e-05	14	31	2	25191221
Pubmed	Role for Lhx2 in corticogenesis through regulation of progenitor differentiation.	NEUROG2 NOTCH1	8.02e-05	15	31	2	23454273
Pubmed	A non-canonical role for the proneural gene Neurog1 as a negative regulator of neocortical neurogenesis.	NEUROG2 NOTCH1	1.04e-04	17	31	2	30201687
Pubmed	Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGFβ signaling to specify V2b interneurons in the spinal cord.	NEUROG2 NOTCH1	1.04e-04	17	31	2	24257627
Pubmed	Notch signaling is a critical initiator of roof plate formation as revealed by the use of RNA profiling of the dorsal neural tube.	NEUROG2 NOTCH1	1.17e-04	18	31	2	33892704
Pubmed	Presenilin enhancer 2 is crucial for the transition of apical progenitors into neurons but into not basal progenitors in the developing hippocampus.	NEUROG2 NOTCH1	1.30e-04	19	31	2	35575074
Pubmed	Lunatic fringe potentiates Notch signaling in the developing brain.	NEUROG2 NOTCH1	1.30e-04	19	31	2	20510365
Pubmed	Functional Cooperation of α-Synuclein and Tau Is Essential for Proper Corticogenesis.	NEUROG2 NOTCH1	1.30e-04	19	31	2	35906071
Pubmed	An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis.	NEUROG2 NOTCH1	1.76e-04	22	31	2	29140246
Pubmed	A novel function for Foxm1 in interkinetic nuclear migration in the developing telencephalon and anxiety-related behavior.	NEUROG2 NOTCH1	1.76e-04	22	31	2	24453338
Pubmed	FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis.	NEUROG2 NOTCH1	1.76e-04	22	31	2	22031906
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	TAB2 TNRC6C ANKHD1 CPEB4	1.86e-04	322	31	4	39098523
Pubmed	Notch signalling regulates epibranchial placode patterning and segregation.	NEUROG2 NOTCH1	1.92e-04	23	31	2	31988190
Pubmed	Slit/Robo signaling modulates the proliferation of central nervous system progenitors.	NEUROG2 NOTCH1	1.92e-04	23	31	2	23083737
Pubmed	Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.	ADAMTS9 CPEB4	2.10e-04	24	31	2	20935629
Pubmed	Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis.	NEUROG2 NOTCH1	2.10e-04	24	31	2	20808958
Pubmed	Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling.	NEUROG2 NOTCH1	2.28e-04	25	31	2	35815610
Pubmed	Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.	NEUROG2 NOTCH1	2.28e-04	25	31	2	39271675
Pubmed	The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord.	NEUROG2 NOTCH1	2.28e-04	25	31	2	23223237
Pubmed	Regulation of differentiation flux by Notch signalling influences the number of dopaminergic neurons in the adult brain.	NEUROG2 NOTCH1	2.47e-04	26	31	2	26912775
Pubmed	SCAP knockout in SM22α-Cre mice induces defective angiogenesis in the placental labyrinth.	GCM1 NOTCH1	2.66e-04	27	31	2	33227706
Pubmed	Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.	ADAMTS9 NOTCH1	2.66e-04	27	31	2	20490451
Pubmed	Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors.	NEUROG2 NOTCH1	2.66e-04	27	31	2	30692224
Pubmed	Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation.	NEUROG2 NOTCH1	2.66e-04	27	31	2	24148613
Pubmed	Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice.	GCM1 NOTCH1	3.08e-04	29	31	2	17573777
Pubmed	Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis.	NEUROG2 RP1L1	3.08e-04	29	31	2	30048641
Pubmed	SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron.	NEUROG2 NOTCH1	3.08e-04	29	31	2	17928865
Pubmed	NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1.	NEUROG2 NOTCH1	3.75e-04	32	31	2	20610746
Pubmed	The transcription factor RBP-J is essential for retinal cell differentiation and lamination.	NEUROG2 NOTCH1	4.24e-04	34	31	2	20017954
Pubmed	Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.	ADAMTS9 NOTCH1	5.30e-04	38	31	2	29743679
Pubmed	Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.	GCM1 NOTCH1	5.30e-04	38	31	2	27930960
Pubmed	MTG8 interacts with LHX6 to specify cortical interneuron subtype identity.	NEUROG2 NOTCH1	5.58e-04	39	31	2	36064547
Pubmed	Notch-Rbpj signaling is required for the development of noradrenergic neurons in the mouse locus coeruleus.	NEUROG2 NOTCH1	5.87e-04	40	31	2	22718343
Pubmed	Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation.	NEUROG2 NOTCH1	6.47e-04	42	31	2	30485816
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	DMBT1 NEUROG2 NOTCH1	8.61e-04	210	31	3	16537572
Interaction	TOP3B interactions	PIKFYVE ATMIN CARD10 TNRC6C PER2 GAREM2 ANKHD1 ZNF827 TESK1 NOTCH1 CPEB4	6.48e-06	1470	31	11	int:TOP3B
Cytoband	Ensembl 112 genes in cytogenetic band chr3p14	CFAP20DC ADAMTS9	4.05e-03	140	31	2	chr3p14
Cytoband	Ensembl 112 genes in cytogenetic band chr10q11	AGAP4 AGAP6	7.17e-03	188	31	2	chr10q11
GeneFamily	Ankyrin repeat domain containing	GIT2 ANKHD1 AGAP4 AGAP6 NOTCH1	7.04e-06	242	21	5	403
GeneFamily	ArfGAPs	GIT2 AGAP4 AGAP6	7.20e-06	33	21	3	395
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP4 AGAP6	1.73e-04	17	21	2	1291
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	AGAP4 AGAP6	2.35e-02	206	21	2	682
Disease	cerebral palsy (implicated_via_orthology)	AGAP4 AGAP6	4.78e-05	10	31	2	DOID:1969 (implicated_via_orthology)
Disease	congenital heart disease (is_implicated_in)	TAB2 NOTCH1	2.91e-04	24	31	2	DOID:1682 (is_implicated_in)
Disease	Malignant neoplasm of breast	NHS PER2 TESK1 MAGEC2 NOTCH1 KRTAP10-8	7.73e-04	1074	31	6	C0006142
Disease	type 1 diabetes mellitus (is_implicated_in)	XYLT1 PTPRN	3.61e-03	85	31	2	DOID:9744 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WPSLATSACTPISTS	AGAP4	321	Q96P64
PWSPGLSSSSSSDSV	CARD10	561	Q9BWT7
SSSSLPSFPSTLSWS	GIT2	556	Q14161
SSCSSSWTSRSVAPG	CASP8AP2	1506	Q9UKL3
WPSLATSACTPISSS	AGAP6	321	Q5VW22
QASPSSHSSTPSWCE	PTPRN	666	Q16849
SPDQWSSSSPHSNVS	NOTCH1	2516	P46531
SQSPLSSCCSSFSWS	MAGEC2	96	Q9UBF1
LSSSGDSPSPASTWS	NEUROG2	201	Q9H2A3
DSPSPASTWSCTNSP	NEUROG2	206	Q9H2A3
ASTWSCTNSPAPSSS	NEUROG2	211	Q9H2A3
WSPSDTSQSSCPAVP	PER2	831	O15055
WSYQTPPSSPSSSSS	MTSS2	256	Q765P7
SAQSSNAPSACVSPW	PIKFYVE	1226	Q9Y2I7
DPWPAFASSSSSSTS	ADAMTS9	81	Q9P2N4
PSAQWATADSSVSSC	ATMIN	426	O43313
TSWPCSFSPSQNSSE	GCM1	321	Q9NP62
SSPSTCTGSSWQVDN	KRTAP10-8	31	P60410
SSYQSPSPTPSSSWS	CPEB4	286	Q17RY0
CSASQSQPTPSPDTW	DMBT1	1221	Q9UGM3
SSCAPSSSSSSEWQE	GAREM2	681	Q75VX8
SQESTSSCSSWGNAP	TNRC6C	906	Q9HCJ0
WTTCPASNPLSHTSS	TAB2	256	Q9NYJ8
SGNWSGSSSTCPSQT	NHS	631	Q6T4R5
NNTDTLSCSSWPTSP	SNTG1	181	Q9NSN8
FSPHPWTSASNSSTS	ANKHD1	2331	Q8IWZ3
TSSDDTTTWNSCLPP	CFAP20DC	586	Q6ZVT6
QTCSQTAWSSFSPDP	XYLT1	931	Q86Y38
SCSWDSEGASSTPST	RP1L1	616	Q8IWN7
ISTCSSASQPWSPRS	TESK1	496	Q15569
WLPNSTTTCSLSPDS	ZNF827	196	Q17R98
SWTAFSTSSSSPGTP	WNK4	796	Q96J92
TSSSAASSWPTAASP	UBALD1	116	Q8TB05