Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	single-stranded RNA binding	ILF3 DAZAP1 ZFR2	8.08e-04	111	33	3	GO:0003727
GeneOntologyMolecularFunction	UDP-galactosyltransferase activity	ABO B3GNT8	1.27e-03	32	33	2	GO:0035250
GeneOntologyMolecularFunction	galactosyltransferase activity	ABO B3GNT8	1.52e-03	35	33	2	GO:0008378
GeneOntologyMolecularFunction	acetylgalactosaminyltransferase activity	ABO GALNT2	1.52e-03	35	33	2	GO:0008376
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	ABO GALNT2 B3GNT8	2.03e-03	153	33	3	GO:0008194
GeneOntologyMolecularFunction	extracellular matrix structural constituent	ENAM FGG TECTB	3.64e-03	188	33	3	GO:0005201
GeneOntologyMolecularFunction	hexosyltransferase activity	ABO GALNT2 B3GNT8	5.02e-03	211	33	3	GO:0016758
GeneOntologyMolecularFunction	manganese ion binding	ABO GALNT2	6.13e-03	71	33	2	GO:0030145
GeneOntologyMolecularFunction	double-stranded RNA binding	ILF3 ZFR2	7.35e-03	78	33	2	GO:0003725
Domain	ZF_C2H2_AKAP95	ZNF326 AKAP8L	9.07e-06	3	33	2	PS51799
Domain	AKAP95	ZNF326 AKAP8L	9.07e-06	3	33	2	IPR007071
Domain	AKAP95	ZNF326 AKAP8L	9.07e-06	3	33	2	PF04988
Domain	DZF_dom	ILF3 ZFR2	3.02e-05	5	33	2	IPR006561
Domain	DZF	ILF3 ZFR2	3.02e-05	5	33	2	SM00572
Domain	DZF	ILF3 ZFR2	3.02e-05	5	33	2	PF07528
Domain	DZF	ILF3 ZFR2	3.02e-05	5	33	2	PS51703
Domain	-	ABO GALNT2	8.99e-03	81	33	2	3.90.550.10
Domain	Nucleotide-diphossugar_trans	ABO GALNT2	1.05e-02	88	33	2	IPR029044
Pubmed	Venous thromboembolism risk associated with ABO, F11 and FGG loci.	FGG ABO	2.62e-06	3	33	2	29995659
Pubmed	Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population.	FGG ABO	2.62e-06	3	33	2	37076872
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SAE1 ZNF326 ILF3 CTNND1 RBMXL3 DAZAP1 AKAP8L CTSC HDAC2	3.67e-06	1371	33	9	36244648
Pubmed	Genetics of venous thrombosis: insights from a new genome wide association study.	FGG ABO	1.83e-05	7	33	2	21980494
Pubmed	A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.	FGG ABO	2.44e-05	8	33	2	23650146
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZNF462 NOL4 NDUFS7 AKAP8L HDAC2	4.40e-05	418	33	5	34709266
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	ZNF326 ILF3 FGG CTNND1 AKAP8L	4.56e-05	421	33	5	34650049
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	ZNF462 ZNF326 DAZAP1 HDAC2	5.52e-05	220	33	4	35785414
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ZNF462 NOL4 ZNF326 NDUFS7 ILF3 AKAP8L HDAC2	5.82e-05	1082	33	7	38697112
Pubmed	Selection system for genes encoding nuclear-targeted proteins.	NOL4 AKAP8L	7.89e-05	14	33	2	9853615
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	ZNF326 ILF3 CTNND1 AKAP8L	8.24e-05	244	33	4	29884807
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	ZNF326 MEX3A ILF3 DAZAP1 AKAP8L HDAC2	9.94e-05	807	33	6	22681889
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	ZNF326 MEX3A ILF3 DAZAP1	1.02e-04	258	33	4	37794589
Pubmed	Genetic predictors of fibrin D-dimer levels in healthy adults.	FGG ABO	1.04e-04	16	33	2	21502573
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	ZNF462 ENAM ILF3 FGG AKAP8L	1.16e-04	513	33	5	25798074
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	SAE1 ZNF326 NDUFS7 ILF3 CTNND1 AKAP8L HDAC2	1.41e-04	1247	33	7	27684187
Pubmed	A global genomic transcriptional code associated with CNS-expressed genes.	ZNF462 ZNF326 HOXD13 TECTB	2.28e-04	318	33	4	16919269
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	ZNF326 ILF3 AKAP8L HDAC2	2.62e-04	330	33	4	33301849
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	ZNF326 ILF3 CTNND1 DAZAP1 AKAP8L HDAC2	2.99e-04	989	33	6	36424410
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	MEX3A ILF3 RBMXL3 DAZAP1	3.17e-04	347	33	4	16033648
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ZNF326 ILF3 CTNND1 GALNT2 DAZAP1 HDAC2	3.60e-04	1024	33	6	24711643
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	ZNF462 ZNF326 ILF3	3.61e-04	146	33	3	23892456
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	ZNF326 ILF3 CTNND1 DAZAP1 HDAC2	3.71e-04	660	33	5	32780723
Pubmed	Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells.	ILF3 RBMXL3 DAZAP1	4.13e-04	153	33	3	28225217
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	ZNF326 ILF3 DAZAP1	4.88e-04	162	33	3	31363146
Pubmed	Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis.	ZNF326 ILF3 DAZAP1	5.81e-04	172	33	3	26336360
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	ZNF462 ILF3 AKAP8L HDAC2	6.00e-04	411	33	4	35182466
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	ZNF326 AKAP8L HDAC2	6.32e-04	177	33	3	26206133
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	ZNF326 ILF3 FGG HDAC2	7.10e-04	430	33	4	38172120
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	ZNF462 HDAC2	7.69e-04	43	33	2	33472061
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	SAE1 ILF3 DAZAP1 AKAP8L	8.62e-04	453	33	4	29656893
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	ZNF326 ILF3 DAZAP1 AKAP8L	9.27e-04	462	33	4	31138677
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	NDUFS7 ILF3 DAZAP1 AKAP8L ZFR2	2.47e-04	797	33	5	chr19p13
Cytoband	19p13.3	NDUFS7 DAZAP1 ZFR2	6.61e-04	237	33	3	19p13.3
GeneFamily	RNA binding motif containing	RBMXL3 DAZAP1	2.73e-02	213	22	2	725
Disease	n-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 measurement	ABO B3GNT8	3.83e-05	9	31	2	EFO_0801817
Disease	Ischemic stroke, venous thromboembolism, stroke, Abnormal thrombosis, deep vein thrombosis, pulmonary embolism	FGG ABO	1.44e-04	17	31	2	EFO_0000712, EFO_0003827, EFO_0003907, EFO_0004286, HP_0001977, HP_0002140
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	FGG ABO	2.22e-04	21	31	2	EFO_0004286, EFO_0004792
Disease	venous thromboembolism, tissue plasminogen activator measurement	FGG ABO	2.67e-04	23	31	2	EFO_0004286, EFO_0004791
Disease	partial thromboplastin time	FGG ABO	2.91e-04	24	31	2	EFO_0004310
Disease	pulmonary embolism	FGG ABO	3.16e-04	25	31	2	EFO_0003827
Disease	cholesterol to total lipids in medium LDL percentage	ABO GALNT2	3.69e-04	27	31	2	EFO_0022238
Disease	D dimer measurement	FGG ABO	4.56e-04	30	31	2	EFO_0004507
Disease	factor XI measurement, venous thromboembolism	FGG ABO	4.56e-04	30	31	2	EFO_0004286, EFO_0004694
Disease	factor VIII measurement, venous thromboembolism	FGG ABO	5.87e-04	34	31	2	EFO_0004286, EFO_0004630
Disease	free cholesterol to total lipids in large VLDL percentage	ABO GALNT2	6.95e-04	37	31	2	EFO_0022281
Disease	venous thromboembolism, factor VII measurement	FGG ABO	7.33e-04	38	31	2	EFO_0004286, EFO_0004619
Disease	venous thromboembolism, von Willebrand factor measurement	FGG ABO	8.96e-04	42	31	2	EFO_0004286, EFO_0004629

Protein segments in the cluster

Peptide	Gene	Start	Entry
GDFYYLGGFFGGSVQ	ABO	261	P16442
YGQYAGYGQDLSGFG	DAZAP1	346	Q96EP5
GYGYGYGQDNTTNYG	AKAP8L	46	Q9ULX6
EEHGYTGSYNYGSYG	RFX4	596	Q33E94
MSHYGSYYGGLGYSC	KRTAP19-1	1	Q8IUB9
YYMYSGGGSALAGGA	GALNT2	21	Q10471
HAGHLNGVYYQGGTY	FGG	366	P02679
NHGGYMNAGAGYGSY	ILF3	661	Q12906
SAPALGYGYHFGNGY	HOXD13	121	P35453
GYGYHFGNGYYSCRM	HOXD13	126	P35453
YSSEYHYVGGFYGGC	CTSC	341	P53634
YGGYVPGYKFQFGHT	FAM166B	241	A8MTA8
VGGLGSMYGGYYYTG	MARVELD2	236	Q8N4S9
GNPYFGYFGYHGFGG	ENAM	196	Q9NRM1
GYFGYHGFGGRPPYY	ENAM	201	Q9NRM1
YDGDIGNYYYGQGHP	HDAC2	16	Q92769
FFEGGYPAYASGGGY	B3GNT8	296	Q7Z7M8
HYHALFTGFGGALGY	SLC45A2	181	Q9UMX9
HYEDGYPGGSDNYGS	CTNND1	216	O60716
LYYSYGLLHTYGSGG	PKDREJ	1866	Q9NTG1
GLLHTYGSGGYALYF	PKDREJ	1871	Q9NTG1
FYYWGLFDGHAGGGA	PPM1J	151	Q5JR12
GDVFGYHGYTFANLG	SAE1	156	Q9UBE0
GEVNGTYYQFGKHYG	NAP1L3	486	Q99457
GGLCYNGVHEGGYYQ	TECTB	56	Q96PL2
GSCANGGGYYHYSYS	NDUFS7	151	O75251
GGGYYHYSYSVVRGC	NDUFS7	156	O75251
GTYSYHSYRGLGGGL	NOL4	551	O94818
TFGHLAGGYDGQYYG	NLN	621	Q9BYT8
HGEGGYYLTSAYGAL	RIN2	731	Q8WYP3
GYGGYQPHSGQDFAY	ZFR2	56	Q9UPR6
YGLSDRYGGGGHYEE	RBMXL3	971	Q8N7X1
RYGGGGHYEEYQGSL	RBMXL3	976	Q8N7X1
LGEQGGDFGYGGYLF	MEX3A	356	A1L020
GAQGGDYFYSFGGCH	SRXN1	86	Q9BYN0
YDHTAWVYTGGYGGG	TECPR1	786	Q7Z6L1
GTGGYYGHSPGYYGQ	ZNF462	81	Q96JM2
ENGAFSGGYHGASGY	TLX2	46	O43763
YGGMDRDYGHGSYGG	ZNF326	31	Q5BKZ1