Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glucokinase activity	HK1 HK2 HK3	1.14e-07	5	46	3	GO:0004340
GeneOntologyMolecularFunction	hexokinase activity	HK1 HK2 HK3	1.14e-07	5	46	3	GO:0004396
GeneOntologyMolecularFunction	fructokinase activity	HK1 HK2 HK3	1.14e-07	5	46	3	GO:0008865
GeneOntologyMolecularFunction	D-glucose binding	HK1 HK2 HK3	4.09e-06	14	46	3	GO:0005536
GeneOntologyMolecularFunction	carbohydrate kinase activity	HK1 HK2 HK3	1.48e-05	21	46	3	GO:0019200
GeneOntologyMolecularFunction	DNA translocase activity	ATRX RAD54B	5.17e-05	5	46	2	GO:0015616
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	RAD54L2 ATRX RAD54B	8.42e-05	37	46	3	GO:0140658
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	CDKL3 PRKDC HK1 HK2 HK3 RIPK1 TRIO RPS6KA2	1.92e-04	709	46	8	GO:0016773
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	CDKL3 PRKDC HK1 HK2 HK3 RIPK1 TRIO TENT5D RPS6KA2	2.46e-04	938	46	9	GO:0016772
GeneOntologyMolecularFunction	kinase activity	CDKL3 PRKDC HK1 HK2 HK3 RIPK1 TRIO RPS6KA2	3.18e-04	764	46	8	GO:0016301
GeneOntologyMolecularFunction	monosaccharide binding	HK1 HK2 HK3	1.37e-03	95	46	3	GO:0048029
GeneOntologyMolecularFunction	protein serine kinase activity	CDKL3 PRKDC RIPK1 TRIO RPS6KA2	1.44e-03	363	46	5	GO:0106310
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ATP11C ATP9A	1.89e-03	28	46	2	GO:0140326
GeneOntologyMolecularFunction	protein kinase activity	CDKL3 PRKDC HK1 RIPK1 TRIO RPS6KA2	2.42e-03	600	46	6	GO:0004672
GeneOntologyMolecularFunction	ATP-dependent activity	ATP11C RAD54L2 ATP9A ATRX DNAH10 RAD54B	2.71e-03	614	46	6	GO:0140657
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	RAD54L2 ATRX RAD54B	3.12e-03	127	46	3	GO:0008094
GeneOntologyMolecularFunction	ATP hydrolysis activity	ATP11C RAD54L2 ATP9A ATRX DNAH10	3.34e-03	441	46	5	GO:0016887
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	CDKL3 PRKDC RIPK1 TRIO RPS6KA2	3.51e-03	446	46	5	GO:0004674
GeneOntologyBiologicalProcess	fructose 6-phosphate metabolic process	HK1 HK2 HK3	5.33e-06	16	45	3	GO:0006002
GeneOntologyBiologicalProcess	canonical glycolysis	HK1 HK2 HK3	1.26e-05	21	45	3	GO:0061621
GeneOntologyBiologicalProcess	NADH regeneration	HK1 HK2 HK3	1.26e-05	21	45	3	GO:0006735
GeneOntologyBiologicalProcess	glucose catabolic process to pyruvate	HK1 HK2 HK3	1.26e-05	21	45	3	GO:0061718
GeneOntologyBiologicalProcess	NAD metabolic process	NADSYN1 HK1 HK2 HK3	2.15e-05	75	45	4	GO:0019674
GeneOntologyBiologicalProcess	carbohydrate phosphorylation	HK1 HK2 HK3	2.16e-05	25	45	3	GO:0046835
GeneOntologyBiologicalProcess	glycolytic process through glucose-6-phosphate	HK1 HK2 HK3	2.16e-05	25	45	3	GO:0061620
GeneOntologyBiologicalProcess	NAD catabolic process	HK1 HK2 HK3	2.16e-05	25	45	3	GO:0019677
GeneOntologyBiologicalProcess	glycolytic process through fructose-6-phosphate	HK1 HK2 HK3	4.18e-05	31	45	3	GO:0061615
GeneOntologyBiologicalProcess	glucose catabolic process	HK1 HK2 HK3	4.60e-05	32	45	3	GO:0006007
GeneOntologyBiologicalProcess	glucose 6-phosphate metabolic process	HK1 HK2 HK3	4.60e-05	32	45	3	GO:0051156
GeneOntologyBiologicalProcess	maintenance of protein location in mitochondrion	HK1 HK2	4.63e-05	5	45	2	GO:0072656
GeneOntologyBiologicalProcess	NADH metabolic process	HK1 HK2 HK3	1.05e-04	42	45	3	GO:0006734
GeneOntologyBiologicalProcess	hexose catabolic process	HK1 HK2 HK3	2.11e-04	53	45	3	GO:0019320
GeneOntologyBiologicalProcess	monosaccharide catabolic process	HK1 HK2 HK3	2.61e-04	57	45	3	GO:0046365
Domain	Hexokinase_C	HK1 HK2 HK3	1.39e-07	5	46	3	IPR022673
Domain	Hexokinase_N	HK1 HK2 HK3	1.39e-07	5	46	3	IPR022672
Domain	Hexokinase_1	HK1 HK2 HK3	1.39e-07	5	46	3	PF00349
Domain	Hexokinase_2	HK1 HK2 HK3	1.39e-07	5	46	3	PF03727
Domain	HEXOKINASE_2	HK1 HK2 HK3	1.39e-07	5	46	3	PS51748
Domain	Hexokinase_BS	HK1 HK2 HK3	1.39e-07	5	46	3	IPR019807
Domain	HEXOKINASE_1	HK1 HK2 HK3	1.39e-07	5	46	3	PS00378
Domain	Hexokinase	HK1 HK2 HK3	2.78e-07	6	46	3	IPR001312
Domain	SNF2_N	RAD54L2 ATRX RAD54B	6.60e-05	32	46	3	IPR000330
Domain	SNF2_N	RAD54L2 ATRX RAD54B	6.60e-05	32	46	3	PF00176
Domain	P_typ_ATPase_c	ATP11C ATP9A	5.30e-04	14	46	2	IPR032630
Domain	P-type_ATPase_N	ATP11C ATP9A	5.30e-04	14	46	2	IPR032631
Domain	P-type_ATPase_IV	ATP11C ATP9A	5.30e-04	14	46	2	IPR006539
Domain	PhoLip_ATPase_C	ATP11C ATP9A	5.30e-04	14	46	2	PF16212
Domain	PhoLip_ATPase_N	ATP11C ATP9A	5.30e-04	14	46	2	PF16209
Domain	Helicase_C	RAD54L2 ATRX RAD54B	2.32e-03	107	46	3	PF00271
Domain	HELICc	RAD54L2 ATRX RAD54B	2.32e-03	107	46	3	SM00490
Domain	Helicase_C	RAD54L2 ATRX RAD54B	2.38e-03	108	46	3	IPR001650
Domain	HELICASE_CTER	RAD54L2 ATRX RAD54B	2.45e-03	109	46	3	PS51194
Domain	HELICASE_ATP_BIND_1	RAD54L2 ATRX RAD54B	2.45e-03	109	46	3	PS51192
Domain	DEXDc	RAD54L2 ATRX RAD54B	2.45e-03	109	46	3	SM00487
Domain	Helicase_ATP-bd	RAD54L2 ATRX RAD54B	2.51e-03	110	46	3	IPR014001
Domain	-	ATP11C ATP9A	2.81e-03	32	46	2	3.40.1110.10
Domain	-	ATP11C ATP9A	2.81e-03	32	46	2	2.70.150.10
Domain	ATPase_P-typ_cyto_domN	ATP11C ATP9A	3.35e-03	35	46	2	IPR023299
Domain	P_typ_ATPase	ATP11C ATP9A	3.54e-03	36	46	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP11C ATP9A	3.54e-03	36	46	2	IPR018303
Domain	ATPASE_E1_E2	ATP11C ATP9A	3.54e-03	36	46	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP11C ATP9A	3.74e-03	37	46	2	IPR008250
Domain	E1-E2_ATPase	ATP11C ATP9A	3.74e-03	37	46	2	PF00122
Domain	HEAT	PRKDC GCN1	6.23e-03	48	46	2	PF02985
Domain	TPR_REGION	PRKDC DNAH10 GTF3C3	7.78e-03	165	46	3	PS50293
Domain	TPR	PRKDC DNAH10 GTF3C3	7.78e-03	165	46	3	PS50005
Domain	Kelch-typ_b-propeller	KLHL35 KLHDC4	8.11e-03	55	46	2	IPR015915
Domain	HEAT	PRKDC GCN1	8.99e-03	58	46	2	IPR000357
Domain	Kinase-like_dom	CDKL3 PRKDC RIPK1 TRIO RPS6KA2	1.04e-02	542	46	5	IPR011009
Domain	DH_1	TRIO SPATA13	1.05e-02	63	46	2	PS00741
Domain	-	ATP11C ATP9A	1.09e-02	64	46	2	3.40.50.1000
Domain	Ser/Thr_kinase_AS	CDKL3 RIPK1 TRIO RPS6KA2	1.14e-02	357	46	4	IPR008271
Domain	S_TKc	CDKL3 RIPK1 TRIO RPS6KA2	1.16e-02	359	46	4	SM00220
Domain	PROTEIN_KINASE_ST	CDKL3 RIPK1 TRIO RPS6KA2	1.19e-02	362	46	4	PS00108
Domain	RhoGEF	TRIO SPATA13	1.22e-02	68	46	2	SM00325
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_FIMA_TO_CROSSTALK_BETWEEN_EXTRINSIC_AND_INTRINSIC_APOPTOTIC_PATHWAYS	HK1 HK2 HK3	2.33e-07	6	33	3	M47654
Pathway	WP_UDPDERIVED_SUGARS_SYNTHESIS_IN_FIBROBLASTS	HK1 HK2 HK3	1.90e-06	11	33	3	M48094
Pathway	KEGG_GALACTOSE_METABOLISM	HK1 HK2 HK3	2.93e-05	26	33	3	M4377
Pathway	KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM	HK1 HK2 HK3	6.66e-05	34	33	3	M15898
Pathway	WP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION	HK1 HK2 HK3	1.09e-04	40	33	3	M39595
Pathway	KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM	HK1 HK2 HK3	1.45e-04	44	33	3	M8104
Pathway	WP_GLYCOLYSIS_AND_GLUCONEOGENESIS	HK1 HK2 HK3	1.55e-04	45	33	3	M39474
Pathway	KEGG_TYPE_II_DIABETES_MELLITUS	HK1 HK2 HK3	1.77e-04	47	33	3	M19708
Pathway	WP_GLYCOLYSIS_AND_GLUCONEOGENESIS	HK1 HK2 HK3	2.25e-04	51	33	3	MM15928
Pathway	KEGG_STARCH_AND_SUCROSE_METABOLISM	HK1 HK2 HK3	2.39e-04	52	33	3	M14171
Pathway	KEGG_GLYCOLYSIS_GLUCONEOGENESIS	HK1 HK2 HK3	4.02e-04	62	33	3	M11521
Pathway	REACTOME_RAC1_GTPASE_CYCLE	DOCK7 TRIO LEMD3 SPATA13	8.55e-04	184	33	4	M41809
Pathway	REACTOME_GLUCOSE_METABOLISM	HK1 HK2 HK3	9.13e-04	82	33	3	MM15394
Pathway	REACTOME_GLUCOSE_METABOLISM	HK1 HK2 HK3	1.01e-03	85	33	3	M1870
Pathway	WP_CLEAR_CELL_RENAL_CELL_CARCINOMA_PATHWAYS	HK1 HK2 HK3	1.05e-03	86	33	3	M39375
Pathway	WP_METABOLIC_EPILEPTIC_DISORDERS	HK1 HK2 HK3	1.23e-03	91	33	3	M48079
Pathway	REACTOME_CDC42_GTPASE_CYCLE	DOCK7 TRIO SPATA13	1.36e-03	94	33	3	MM15598
Pathway	KEGG_MEDICUS_REFERENCE_TNF_P38_SIGNALING_PATHWAY	RIPK1 CREB3L4	1.42e-03	24	33	2	M47568
Pubmed	[Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods].	HK1 HK2 HK3	2.17e-09	3	46	3	26855992
Pubmed	Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.	HK1 HK2 HK3	8.65e-09	4	46	3	25904018
Pubmed	High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3.	HK1 HK2 HK3	8.65e-09	4	46	3	25766729
Pubmed	Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma.	HK1 HK2 HK3	1.81e-07	9	46	3	19554504
Pubmed	Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice.	HK1 HK2 HK3	1.81e-07	9	46	3	21074528
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DOCK7 POR PRKDC HK1 HK2 ATRX DNAH10 TRIO GCN1 SRSF9 GTF3C3 RPF2	2.28e-07	1425	46	12	30948266
Pubmed	Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury.	HK1 HK2	1.71e-06	2	46	2	24990892
Pubmed	The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia-reperfusion injury.	HK1 HK2	1.71e-06	2	46	2	21504994
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	POR PRKDC NCSTN HK2 ATP9A KLHDC4 LEMD3 GCN1 GTF3C3	3.38e-06	942	46	9	31073040
Pubmed	Effect of Increased IL-1β on Expression of HK in Alzheimer's Disease.	HK1 HK2	5.13e-06	3	46	2	33525649
Pubmed	Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.	HK1 HK2	5.13e-06	3	46	2	19049977
Pubmed	Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress.	HK1 HK2	5.13e-06	3	46	2	21430642
Pubmed	Fubp1 supports the lactate-Akt-mTOR axis through the upregulation of Hk1 and Hk2.	HK1 HK2	5.13e-06	3	46	2	30871777
Pubmed	A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.	HK1 HK2	5.13e-06	3	46	2	20347420
Pubmed	c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.	HK1 HK2	5.13e-06	3	46	2	28054552
Pubmed	Rad54/Rad54B deficiency is associated to increased chromosome breakage in mouse spermatocytes.	ATRX RAD54B	5.13e-06	3	46	2	30204892
Pubmed	Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.	HK1 HK2 HK3	8.57e-06	30	46	3	27133129
Pubmed	Hexokinase activity is required for recruitment of parkin to depolarized mitochondria.	HK1 HK2	1.03e-05	4	46	2	23962723
Pubmed	Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation.	PRKDC ATRX	1.03e-05	4	46	2	20150414
Pubmed	A novel human rad54 homologue, Rad54B, associates with Rad51.	ATRX RAD54B	1.03e-05	4	46	2	10851248
Pubmed	Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program.	HK1 HK2	1.03e-05	4	46	2	32152094
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DOCK7 ATP9A MEGF9 RABGAP1L SPATA13 EPG5	1.56e-05	407	46	6	12693553
Pubmed	Functional complementation between FADD and RIP1 in embryos and lymphocytes.	PRKDC RIPK1	1.71e-05	5	46	2	21368761
Pubmed	Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak.	HK1 HK2	1.71e-05	5	46	2	15574336
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	POR ERMP1 PRKDC HK2 MRPL24 GCN1	1.91e-05	422	46	6	27342126
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	DOCK7 PRKDC HK1 HK2 GCN1 SRSF9 RPF2	2.26e-05	653	46	7	33742100
Pubmed	Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.	ATRX RAD54B	2.56e-05	6	46	2	17118963
Pubmed	ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.	PRKDC RPS6KA2	2.56e-05	6	46	2	14966265
Pubmed	T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death.	PRKDC RIPK1	2.56e-05	6	46	2	34752416
Pubmed	Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.	NCSTN ATP9A	2.56e-05	6	46	2	26094765
Pubmed	Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver.	HK1 HK2	3.58e-05	7	46	2	18165236
Pubmed	Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase.	HK2 HK3	4.77e-05	8	46	2	11068878
Pubmed	Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins.	ATRX SVEP1	4.77e-05	8	46	2	15522233
Pubmed	RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells.	PRKDC RIPK1	6.12e-05	9	46	2	35688159
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	DOCK7 POR PRKDC HK1 LEMD3 GCN1 GTF3C3	6.78e-05	777	46	7	35844135
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	RIPK1 ATRX MRPL24 SRSF9 GTF3C3 RPF2	7.01e-05	533	46	6	30554943
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	DOCK7 PRKDC NCSTN HK2 GCN1 GTF3C3	7.09e-05	534	46	6	35032548
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	PRKDC HK2 RAD54L2 ATRX GCN1	7.65e-05	332	46	5	32786267
Pubmed	The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease.	ATP11C ATP9A	7.65e-05	10	46	2	15919184
Pubmed	Proteomics identifies the developmental regulation of HKDC1 in liver of pigs and mice.	HK1 HK2	7.65e-05	10	46	2	37545422
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DOCK7 PRKDC HK1 GCN1 SRSF9 COG4 GTF3C3 RPF2	7.81e-05	1082	46	8	38697112
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	ATP11C NADSYN1 ATP9A ATRX SVEP1 RAD54B	8.50e-05	552	46	6	10737800
Pubmed	An analysis of expression patterns of genes encoding proteins with catalytic activities.	HK1 HK2 HK3	9.78e-05	67	46	3	17626619
Pubmed	ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.	ATP11C ATP9A	1.12e-04	12	46	2	21914794
Pubmed	Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.	DOCK7 PRKDC GCN1	1.21e-04	72	46	3	36376293
Pubmed	Differential expression of putative transbilayer amphipath transporters.	ATP11C ATP9A	1.32e-04	13	46	2	11015572
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DOCK7 PRKDC TRIO GCN1	1.49e-04	202	46	4	33005030
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	DOCK7 PRKDC GCN1 RPF2	1.49e-04	202	46	4	24639526
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	DOCK7 TRAF3IP1 GCN1 SRSF9 GTF3C3	1.62e-04	390	46	5	17643375
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	POR ATP11C NCSTN HK2 GCN1	1.66e-04	392	46	5	33144569
Pubmed	Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations.	DOCK7 HPS3	1.78e-04	15	46	2	2379821
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DOCK7 HK2 RAD54L2 ATRX COG4 RAD54B	2.07e-04	650	46	6	38777146
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	PRKDC GCN1 SRSF9 GTF3C3	2.10e-04	221	46	4	29991511
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DOCK7 PRKDC HK1 GCN1 GTF3C3 RPF2	2.12e-04	653	46	6	22586326
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	PRKDC HK1 HK2 GCN1	2.65e-04	235	46	4	28378594
Pubmed	Network organization of the human autophagy system.	PRKDC HK1 GCN1 GTF3C3 RABGAP1L	2.75e-04	437	46	5	20562859
Pubmed	Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress.	PRKDC ATRX	2.88e-04	19	46	2	23329831
Pubmed	The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.	PRKDC ATRX	2.88e-04	19	46	2	20504901
Pubmed	Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.	DOCK7 PRKDC HK1 GCN1	2.92e-04	241	46	4	23125841
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	ATP9A TRIO SORCS1	3.30e-04	101	46	3	18519826
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	PRKDC RAD54L2 ATRX	3.80e-04	106	46	3	19394292
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	PRKDC MRPL24 SRSF9 RPF2	3.83e-04	259	46	4	30404004
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	RAD54L2 GCN1 GTF3C3 RPF2	4.01e-04	262	46	4	36880596
Pubmed	A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.	ATP11C PRKDC	4.25e-04	23	46	2	22761313
Pubmed	ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.	POR ERMP1 PRKDC GCN1	4.36e-04	268	46	4	33024031
Pubmed	Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.	HK1 HK2 HK3	4.70e-04	114	46	3	28245920
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	POR ATP9A LEMD3 COG4 HPS3	5.26e-04	504	46	5	34432599
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	ERMP1 NCSTN LEMD3 GCN1	5.28e-04	282	46	4	35007762
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	DOCK7 PRKDC HK1 HK2 GCN1 SRSF9 COG4 RPF2	5.43e-04	1440	46	8	30833792
Pubmed	Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.	PRKDC RAD54B	5.88e-04	27	46	2	20610542
Pubmed	Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.	SLC9A9 EPG5	5.88e-04	27	46	2	18649358
Pubmed	Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.	PRKDC GCN1	6.33e-04	28	46	2	35227662
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	DOCK7 PRKDC GCN1 SRSF9 GTF3C3 SORCS1	6.59e-04	809	46	6	32129710
Pubmed	Characterising the dynamics of placental glycogen stores in the mouse.	HK1 HK2	6.79e-04	29	46	2	32798765
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	DOCK7 NADSYN1 HK1 COG4	6.99e-04	304	46	4	32235678
Pubmed	Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation.	CDKL3 HK1 TRAF3IP1 MRPL24	7.08e-04	305	46	4	21244100
Pubmed	Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.	DOCK7 DNAH10	7.27e-04	30	46	2	19936222
Pubmed	UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.	PRKDC GCN1	7.27e-04	30	46	2	32867711
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	PRKDC HK1 HK2 GCN1	7.70e-04	312	46	4	37120454
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	DOCK7 ATP11C GCN1 GTF3C3	7.80e-04	313	46	4	38270169
Pubmed	TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment.	TRAF3IP1 ATRX MRPL24	8.19e-04	138	46	3	37506885
Pubmed	Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.	DOCK7 RIPK1	8.28e-04	32	46	2	20056645
Pubmed	Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.	PRKDC GCN1	9.35e-04	34	46	2	11101529
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	DOCK7 PRKDC GCN1 SRSF9 GTF3C3	1.16e-03	601	46	5	33658012
Pubmed	Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury.	HK1 HK2	1.17e-03	38	46	2	20185832
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	PRKDC NCSTN HK2 GCN1 RPF2	1.26e-03	613	46	5	22268729
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	PRKDC ATRX GCN1 GTF3C3	1.27e-03	357	46	4	37059091
Cytoband	3q24	SLC9A9 HPS3	4.48e-04	31	46	2	3q24
Cytoband	Xq21.1	ATRX TENT5D	5.08e-04	33	46	2	Xq21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3q24	SLC9A9 HPS3	1.03e-03	47	46	2	chr3q24
Cytoband	16q24.3	CENPBD1P KLHDC4	1.26e-03	52	46	2	16q24.3
Cytoband	11q13.4	KLHL35 NADSYN1	2.60e-03	75	46	2	11q13.4
Cytoband	12q24.31	DNAH10 SRSF9	2.95e-03	80	46	2	12q24.31
GeneFamily	ATPase phospholipid transporting	ATP11C ATP9A	2.23e-04	15	27	2	1210
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIO SPATA13	4.34e-03	66	27	2	722
GeneFamily	Solute carriers	SLC9A9 SLC7A14 SLC10A4	2.05e-02	395	27	3	752
CoexpressionAtlas	DevelopingKidney_e15.5_Endothelial cells_emap-29965_k-means-cluster#5_top-relative-expression-ranked_1000	ATP11C ATRX TRIO RABGAP1L	2.74e-05	84	44	4	gudmap_developingKidney_e15.5_Endothelial cells_1000_k5
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	PRKDC ADGRV1 ATP9A ATRX LEMD3 GTF3C3	4.68e-08	193	46	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
Drug	galactosone	HK1 HK2 HK3 TRIO	2.61e-08	16	46	4	CID000097398
Drug	2,3-anhydro-D-allose	HK1 HK2 HK3	3.08e-08	4	46	3	CID000191595
Drug	lofenal	HK1 HK2 HK3	3.08e-08	4	46	3	CID000159256
Drug	N-bromoacetylglucosamine	HK1 HK2 HK3	3.08e-08	4	46	3	CID000152920
Drug	1,5-anhydroglucitol 6-phosphate	HK1 HK2 HK3	3.08e-08	4	46	3	CID003081444
Drug	1-deoxy-D-manno-heptulose	HK1 HK2 HK3	3.08e-08	4	46	3	CID000193198
Drug	AC1L5VHN	HK1 HK2 HK3	3.08e-08	4	46	3	CID000235938
Drug	3-chloromethylthiochromone-1,1-dioxide	HK1 HK2 HK3	7.70e-08	5	46	3	CID000100620
Drug	2-fluoro-2-deoxy-6-phosphogluconate	HK1 HK2 HK3	7.70e-08	5	46	3	CID000127270
Drug	8-thiocyano-ATP	HK1 HK2 HK3	1.54e-07	6	46	3	CID000132196
Drug	glucose 6-arsenate	HK1 HK2 HK3	2.69e-07	7	46	3	CID000128033
Drug	AC1L5A5F	HK1 HK2 HK3	2.69e-07	7	46	3	CID000173497
Drug	AFDG	HK1 HK2 HK3	4.29e-07	8	46	3	CID000164297
Drug	tetrahydropyran-2-methanol	HK1 HK2 HK3	4.29e-07	8	46	3	CID000007524
Drug	ATP-EDC	HK1 HK2 HK3	9.17e-07	10	46	3	CID000195647
Drug	triethyltin bromide	HK1 HK2 HK3	2.18e-06	13	46	3	CID000017701
Drug	AC1Q6HGX	HK1 HK2 HK3	3.45e-06	15	46	3	CID000000600
Drug	morpholine-citrate	HK1 HK2 HK3	6.17e-06	18	46	3	CID000173845
Drug	AC1Q6RZ6	HK1 HK2 HK3 GCN1	6.54e-06	60	46	4	CID000000609
Drug	o-toluidine	HK1 HK2 HK3	8.59e-06	20	46	3	CID000007242
Drug	NSC 226836	HK1 HK2 HK3	8.59e-06	20	46	3	CID000012600
Drug	2-deoxy-D-glucose 6-phosphate	HK1 HK2 HK3	1.00e-05	21	46	3	CID000440992
Drug	2-deoxy-2-fluoro-D-talose	HK1 HK2 HK3	1.94e-05	26	46	3	CID000068614
Drug	ATP beta S	HK1 HK2 HK3	2.72e-05	29	46	3	CID000123766
Drug	mg U	HK1 HK2 HK3	3.02e-05	30	46	3	CID000445508
Drug	acetylphenylhydrazine	HK1 HK2 HK3	3.33e-05	31	46	3	CID000008247
Drug	2,5-anhydro-D-mannitol	HK1 HK2 HK3	3.33e-05	31	46	3	CID000001494
Drug	AP2PL	HK1 HK2 HK3	3.33e-05	31	46	3	CID000121867
Drug	procarbazine	POR HK1 HK2 HK3	3.73e-05	93	46	4	CID000004915
Drug	lonidamine	HK1 HK2 HK3	4.04e-05	33	46	3	CID000039562
Drug	3-OMG	HK1 HK2 HK3	4.04e-05	33	46	3	CID000097217
Drug	2-deoxy-D-arabino-hexose 6-phosphate	HK1 HK2 HK3	4.42e-05	34	46	3	CID000108108
Drug	Tiapride hydrochloride [51012-33-0]; Down 200; 11uM; MCF7; HT_HG-U133A	CDKL3 MEGF9 TRIO RPS6KA2 RABGAP1L	4.51e-05	195	46	5	4686_DN
Drug	riboxin	HK1 HK2 HK3	5.26e-05	36	46	3	CID000006831
Drug	AC1L1IM7	HK1 HK2 HK3	1.10e-04	46	46	3	CID000004638
Drug	AC1Q6RZ4	HK1 HK2 HK3 GCN1	1.11e-04	123	46	4	CID000000719
Drug	AC1Q6RZL	HK1 HK2 HK3	1.18e-04	47	46	3	CID000001144
Drug	CID5288005	HK1 HK2 HK3	1.25e-04	48	46	3	CID005288004
Drug	glucitol-6-phosphate	HK1 HK2 HK3	1.33e-04	49	46	3	CID000000618
Drug	3-bromopyruvate	HK1 HK2 HK3	1.59e-04	52	46	3	CID000070684
Drug	2,3-DPG	HK1 ADGRV1 HK2 HK3	1.68e-04	137	46	4	CID000000061
Drug	18F-FDG	HK1 HK2 HK3	1.68e-04	53	46	3	CID000315411
Drug	AC1L494B	HK1 HK2 HK3	1.68e-04	53	46	3	CID000181487
Drug	GDP-Man	HK1 HK2 HK3 LEMD3	1.83e-04	140	46	4	CID000000732
Drug	AC1L1DKE	HK1 HK2 HK3	1.88e-04	55	46	3	CID000002388
Drug	DB07744	HK1 HK2 HK3	1.88e-04	55	46	3	CID011840941
Drug	Ptpc	HK1 HK2 HK3	1.88e-04	55	46	3	CID003036276
Drug	first rate	HK1 HK2	2.17e-04	11	46	2	CID000086453
Drug	[(2S)-2-[(Z)-dodec-9-enoyl]oxy-3-tetradecanoyloxypropyl] [(2R,3R,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl] phosphate	HK1 HK2 HK3	2.44e-04	60	46	3	CID011968289
Drug	AC1Q6S1V	HK1 HK2 HK3	2.82e-04	63	46	3	CID000000620
Drug	1,6-di-o-phosphonohexopyranose	HK1 HK2 HK3	2.95e-04	64	46	3	CID000000737
Drug	glyceraldehyde-3-phosphate	HK1 ADGRV1 HK2 HK3	2.97e-04	159	46	4	CID000000729
Drug	Verteporfin [129497-78-5]; Down 200; 2.8uM; MCF7; HT_HG-U133A	ERMP1 NCSTN ATP9A MEGF9	3.12e-04	161	46	4	3556_DN
Drug	allulose 6-phosphate	HK1 HK2 HK3 GCN1	3.19e-04	162	46	4	CID000000603
Drug	mannose-1-phosphate	HK1 HK2 HK3 LEMD3	3.42e-04	165	46	4	CID000000466
Drug	dimethyl suberimidate	HK1 HK2 HK3	3.53e-04	68	46	3	CID000034750
Drug	AD 288	PRKDC RPS6KA2	3.58e-04	14	46	2	CID000073553
Drug	AC1L19C4	HK1 HK2 HK3	3.68e-04	69	46	3	CID000000483
Disease	glucose metabolism disease (implicated_via_orthology)	HK1 HK2 HK3	1.06e-05	28	45	3	DOID:4194 (implicated_via_orthology)
Disease	hyperinsulinemic hypoglycemia (implicated_via_orthology)	HK2 HK3	2.27e-05	5	45	2	DOID:13317 (implicated_via_orthology)
Disease	Metastatic melanoma	PRKDC TRIO RPS6KA2	7.79e-05	54	45	3	C0278883
Disease	urinary bladder cancer (implicated_via_orthology)	NCSTN HK1	8.13e-05	9	45	2	DOID:11054 (implicated_via_orthology)
Disease	maturity-onset diabetes of the young (implicated_via_orthology)	HK2 HK3	1.02e-04	10	45	2	DOID:0050524 (implicated_via_orthology)
Disease	platelet storage pool deficiency (implicated_via_orthology)	DOCK7 HPS3	2.36e-04	15	45	2	DOID:2223 (implicated_via_orthology)
Disease	hyperglycemia (implicated_via_orthology)	HK2 HK3	3.05e-04	17	45	2	DOID:4195 (implicated_via_orthology)
Disease	Adenocarcinoma of large intestine	PRKDC RIPK1 RPS6KA2	4.29e-04	96	45	3	C1319315

Protein segments in the cluster

Peptide	Gene	Start	Entry
KRIGYMIRMTLGYVS	EPG5	641	Q9HCE0
LIGLYVTMEEYFMRE	COG4	416	Q9H9E3
MEMYETLGKVGEGSY	CDKL3	1	Q8IVW4
LIREKGTYGMVMVTF	ADGRV1	171	Q8WXG9
EGGVLLMGYEMYRLL	RAD54L2	396	Q9Y4B4
NYMVVMGVVLYLGKK	ERMP1	421	Q7Z2K6
KEGIIFLYECVMGMR	RAD54B	301	Q9Y620
DYIGSSRMVYDMEKG	NCSTN	336	Q92542
GVVMVCVVLRYMKYR	LEMD3	641	Q9Y2U8
GIFVLIYKMYGSEML	SLC10A4	376	Q96EP9
EVIRMTGFMKGLYTD	TRAF3IP1	41	Q8TDR0
AKVYMGEMGRLKSYE	POR	256	P16435
GKVMVREIYYITEDM	KIAA1109	81	Q2LD37
FEKMISGMYLGEIVR	HK2	741	P52789
VLLMGFVGAVYMYRE	MEGF9	526	Q9H1U4
EVMGRLMEIYQEKLY	GCN1	1196	Q92616
YMKGADVVMAGIVQY	ATP9A	566	O75110
YEKMISGMYLGEIVR	HK1	741	P19367
RFEKMISGMYLGEIV	HK3	746	P52790
MISYGYIGISIMKIT	OR5AN1	216	Q8NGI8
MESMGKSYDGRAYVI	RABGAP1L	351	Q5R372
GGVMIIGYEMYRNLA	ATRX	1676	P46100
PEMLIDLMYRIAKGY	DOCK7	1666	Q96N67
MLAVKHGVLYVYGGM	KLHDC4	436	Q8TBB5
MSGLRMIYELYEGLK	DNAH10	1261	Q8IVF4
EFMVDKAIYLSGYRM	ENOX1	186	Q8TC92
MLYEVVYEAGALERM	CREB3L4	111	Q8TEY5
GVGMVEYLRKEDMEY	SRSF9	146	Q13242
MVYGLIMGLILRYAT	SLC9A9	56	Q8IVB4
VGYLYMVVKSVELMS	HPS3	351	Q969F9
EGMTKYDYLMTLHGV	TENT5D	291	Q8NEK8
VIIEEGKYSLVMEYM	RIPK1	81	Q13546
EVSGIYGYVMLDGML	SVEP1	1431	Q4LDE5
RYIGKTMDYRGTMIP	MRPL24	96	Q96A35
VIAYIMETFGMKYRD	STYX	131	Q8WUJ0
GRMYDYHVLDMIELG	RPF2	106	Q9H7B2
QGKMYGYVDTLLTML	GTF3C3	546	Q9Y5Q9
MYTEMLKSIIEEGEY	CENPBD1P	166	B2RD01
YGVAVYTGMETKMAL	ATP11C	261	Q8NB49
YYTMRIRLGLPGKMD	SLC7A14	541	Q8TBB6
LYYKGRLDMDEMELV	SPATA13	496	Q96N96
IEKMYERMYAALGDP	PRKDC	3606	P78527
MIDLYEVAGIKGMFL	SORCS1	466	Q8WY21
RDLGYVVEGYMALMK	TRIO	1986	O75962
IYVMGGLMSKIFTYD	KLHL35	491	Q6PF15
YDDGKFVYLVMELMR	RPS6KA2	476	Q15349
MGMTYAELSVYGKLR	NADSYN1	591	Q6IA69