Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity	MFSD2A MYH13 MYO1E MYH7B RSF1 KIF12 MACF1 MCM3 ABCC2 SRCAP DICER1	9.78e-05	614	90	11	GO:0140657
GeneOntologyCellularComponent	myosin complex	MYH13 MYO1E MYH7B CGNL1	1.22e-04	59	90	4	GO:0016459
GeneOntologyCellularComponent	chromatin	NEUROD2 CEBPE ARID4B ATXN7 NFIL3 FOSB TRPS1 RSF1 MSL3 DBP PBX1 SRCAP TEF EZH2 PBX3 NEUROG3 CREB3	1.70e-04	1480	90	17	GO:0000785
GeneOntologyCellularComponent	RNA polymerase II transcription regulator complex	CEBPE ATXN7 NFIL3 XBP1 DBP PBX1 CREB3	1.74e-04	272	90	7	GO:0090575
GeneOntologyCellularComponent	actin cytoskeleton	SPTBN4 DENND2A CDC42BPA MYH13 MYO1E TJP1 MYH7B ANKRD62 MACF1 CGNL1	1.85e-04	576	90	10	GO:0015629
GeneOntologyCellularComponent	nuclear protein-containing complex	ELL2 CEBPE ARID4B ATXN7 CWC27 NFIL3 ABRAXAS1 RSF1 XBP1 MCM3 PAGR1 DBP PBX1 SRCAP EZH2 CREB3	2.39e-04	1377	90	16	GO:0140513
GeneOntologyCellularComponent	intercellular canaliculus	TJP1 ABCC2	6.47e-04	9	90	2	GO:0046581
GeneOntologyCellularComponent	transcription regulator complex	CEBPE ATXN7 NFIL3 XBP1 DBP PBX1 PBX3 SPEN CREB3	1.06e-03	596	90	9	GO:0005667
GeneOntologyCellularComponent	semaphorin receptor complex	PLXNA1 PLXNB3	1.39e-03	13	90	2	GO:0002116
HumanPheno	Sclerosis of distal finger phalanx	TRPS1 SRCAP	2.71e-05	2	27	2	HP:0100915
HumanPheno	Ivory epiphyses of the distal phalanges of the hand	TRPS1 SRCAP	2.71e-05	2	27	2	HP:0010252
Domain	bZIP_2	CEBPE NFIL3 FOSB XBP1 DBP TEF	1.09e-10	17	88	6	PF07716
Domain	BRLZ	CEBPE NFIL3 FOSB XBP1 DBP TEF CREB3	4.56e-09	52	88	7	SM00338
Domain	BZIP	CEBPE NFIL3 FOSB XBP1 DBP TEF CREB3	5.23e-09	53	88	7	PS50217
Domain	BZIP_BASIC	CEBPE NFIL3 FOSB XBP1 DBP TEF CREB3	5.23e-09	53	88	7	PS00036
Domain	bZIP	CEBPE NFIL3 FOSB XBP1 DBP TEF CREB3	5.98e-09	54	88	7	IPR004827
Domain	TF_DNA-bd	CEBPE FOSB XBP1 CREB3	2.70e-05	37	88	4	IPR008917
Domain	SPOC_met	RBM15 SPEN	6.56e-05	3	88	2	IPR010912
Domain	Myosin_tail_1	MYH13 MYH7B CGNL1	7.84e-05	18	88	3	PF01576
Domain	Myosin_tail	MYH13 MYH7B CGNL1	7.84e-05	18	88	3	IPR002928
Domain	SPOC	RBM15 SPEN	1.31e-04	4	88	2	PS50917
Domain	PBC	PBX1 PBX3	1.31e-04	4	88	2	PF03792
Domain	PBX	PBX1 PBX3	1.31e-04	4	88	2	IPR005542
Domain	-	RBM15 SPEN	2.17e-04	5	88	2	2.40.290.10
Domain	SPOC-like_C_dom	RBM15 SPEN	2.17e-04	5	88	2	IPR016194
Domain	Tudor-knot	ARID4B MSL3	3.25e-04	6	88	2	IPR025995
Domain	Tudor-knot	ARID4B MSL3	3.25e-04	6	88	2	PF11717
Domain	SPOC_C	RBM15 SPEN	3.25e-04	6	88	2	IPR012921
Domain	SPOC	RBM15 SPEN	3.25e-04	6	88	2	PF07744
Domain	Myosin_head_motor_dom	MYH13 MYO1E MYH7B	7.57e-04	38	88	3	IPR001609
Domain	MYOSIN_MOTOR	MYH13 MYO1E MYH7B	7.57e-04	38	88	3	PS51456
Domain	Myosin_head	MYH13 MYO1E MYH7B	7.57e-04	38	88	3	PF00063
Domain	MYSc	MYH13 MYO1E MYH7B	7.57e-04	38	88	3	SM00242
Domain	Plexin_cytopl	PLXNA1 PLXNB3	7.73e-04	9	88	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNA1 PLXNB3	7.73e-04	9	88	2	IPR013548
Domain	Plexin	PLXNA1 PLXNB3	7.73e-04	9	88	2	IPR031148
Domain	IQ_motif_EF-hand-BS	MYH13 MYO1E MYH7B CEP131	8.63e-04	90	88	4	IPR000048
Domain	IQ	MYH13 MYO1E MYH7B CEP131	9.76e-04	93	88	4	PS50096
Domain	P-loop_NTPase	TRIT1 MYH13 MYO1E TJP1 MYH7B KIF12 EIF5B MCM3 ABCC2 SRCAP DICER1	2.08e-03	848	88	11	IPR027417
Domain	Myosin_N	MYH13 MYH7B	2.21e-03	15	88	2	PF02736
Domain	Myosin_N	MYH13 MYH7B	2.21e-03	15	88	2	IPR004009
Domain	Myosin-like_IQ_dom	MYH13 MYH7B	3.56e-03	19	88	2	IPR027401
Domain	-	MYH13 MYH7B	3.56e-03	19	88	2	4.10.270.10
Domain	CH	SPTBN4 EHBP1L1 MACF1	3.58e-03	65	88	3	SM00033
Domain	CH	SPTBN4 EHBP1L1 MACF1	4.41e-03	70	88	3	PF00307
Domain	IQ	MYH13 MYO1E CEP131	4.59e-03	71	88	3	PF00612
Domain	-	SPTBN4 EHBP1L1 MACF1	4.59e-03	71	88	3	1.10.418.10
Pubmed	Comprehensive identification of human bZIP interactions with coiled-coil arrays.	CEBPE NFIL3 XBP1 DBP TEF CREB3	3.02e-11	23	93	6	12805554
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RBM15 ARID4B ARGLU1 ATXN7 PURB ASPH MSL3 EIF5B MCM3 PAGR1 SCFD1 EZH2 YTHDC1 SPEN	1.90e-08	774	93	14	15302935
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SPTBN4 CFAP20DC RBM15 MYO1E CWC27 MACF1 MTCL1 YTHDC1 SPEN FAM43A	4.83e-08	361	93	10	26167880
Pubmed	Networks of bZIP protein-protein interactions diversified over a billion years of evolution.	CEBPE NFIL3 XBP1 DBP CREB3	7.49e-08	40	93	5	23661758
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	LSR CDC42BPA NOP16 ARGLU1 ATXN7 CWC27 PURB TRPS1 ASPH EIF5B WHAMM MACF1 MRPS16 CEP131 EZH2 YTHDC1 SPEN DICER1	7.85e-08	1497	93	18	31527615
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	RBM15 EHBP1L1 CDC42BPA ARGLU1 TJP1 MRPL55 EIF5B MACF1 MCM3 MRPS16 MRPL46 SRCAP YTHDC1 SPEN NKAPL	1.82e-07	1082	93	15	38697112
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	NEK4 TJP1 ATXN7 ASPH KIF12 MTCL1 DBP TEF TTLL7	7.10e-07	371	93	9	15747579
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	RBM15 ARGLU1 PURB TRPS1 ASPH EIF5B MACF1 MRPS16 YTHDC1 CTDNEP1	8.92e-07	496	93	10	31343991
Pubmed	A census of human transcription factors: function, expression and evolution.	NEUROD2 CEBPE NFIL3 FOSB TRPS1 XBP1 DBP PBX1 TEF EZH2 PBX3 NEUROG3 CREB3	9.09e-07	908	93	13	19274049
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	RBM15 RSF1 EIF5B MCM3 CEP131 MTCL1 EZH2 YTHDC1 SPEN PDCD4	1.01e-06	503	93	10	16964243
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	TDRD15 LSR CDC42BPA MYH13 DSCAM CCDC146 TJP1 MCM3 CEP131 SCFD1 CGNL1 SPEN	1.13e-06	777	93	12	35844135
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SPTBN4 MYH13 RRP36 TJP1 ATXN7 CWC27 MYH7B ZNF330 RSF1 MARF1 EIF5B MACF1 ABCC2 SRCAP SPEN UTP14C	1.31e-06	1442	93	16	35575683
Pubmed	REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.	NFIL3 DBP TEF	1.54e-06	9	93	3	19721697
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	RBM15 CDC42BPA MYH13 NGEF MACF1 CGNL1 UTP14C	3.31e-06	234	93	7	36243803
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	RBM15 MYH13 TJP1 PURB MRPS16 YTHDC1 SPEN	6.27e-06	258	93	7	37794589
Pubmed	RBM15-Mediated N6-Methyl Adenosine (m6A) Modification of EZH2 Drives the Epithelial-Mesenchymal Transition of Cervical Cancer.	RBM15 EZH2	7.07e-06	2	93	2	38842201
Pubmed	Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress.	ATG16L1 XBP1	7.07e-06	2	93	2	32673694
Pubmed	TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins.	DBP TEF	7.07e-06	2	93	2	1916262
Pubmed	PBX1 promotes development of natural killer cells by binding directly to the Nfil3 promoter.	NFIL3 PBX1	7.07e-06	2	93	2	32190943
Pubmed	Interference with endogenous EZH2 reverses the chemotherapy drug resistance in cervical cancer cells partly by up-regulating Dicer expression.	EZH2 DICER1	7.07e-06	2	93	2	26631032
Pubmed	Chromosomal localization and cDNA cloning of the human DBP and TEF genes.	DBP TEF	7.07e-06	2	93	2	7835883
Pubmed	Myosin 1e is a component of the glomerular slit diaphragm complex that regulates actin reorganization during cell-cell contact formation in podocytes.	MYO1E TJP1	7.07e-06	2	93	2	23761676
Pubmed	The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue-specific expression, but have different target promoter preferences.	DBP TEF	7.07e-06	2	93	2	8617210
Pubmed	Chromatin changes in dicer-deficient mouse embryonic stem cells in response to retinoic acid induced differentiation.	EZH2 DICER1	7.07e-06	2	93	2	24040281
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SPTBN4 NEUROD2 DSCAM MYO1E ARGLU1 TJP1 TRPS1 NGEF WHAMM MACF1 PBX1 PBX3 FRMD4B PLXNB3	8.01e-06	1285	93	14	35914814
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	RBM15 LSR ARID4B RSF1 MSL3 SPAG7 CEP131 SRCAP SPEN PDCD4	9.11e-06	645	93	10	25281560
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	LSR NFIL3 FOSB TRPS1 XBP1 SRCAP TEF PBX3 PLXNA1 NEUROG3 CREB3	1.07e-05	808	93	11	20412781
Pubmed	The contribution of de novo coding mutations to autism spectrum disorder.	DSCAM SRCAP SPEN	1.47e-05	18	93	3	25363768
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RBM15 LSR RRP36 ARGLU1 TJP1 EIF5B MACF1 MCM3 CEP131 SRCAP SPEN DICER1	1.85e-05	1024	93	12	24711643
Pubmed	Exosomal lncRNA NEAT1 Inhibits NK-Cell Activity to Promote Multiple Myeloma Cell Immune Escape via an EZH2/PBX1 Axis.	PBX1 EZH2	2.12e-05	3	93	2	37889101
Pubmed	The TALE homeodomain protein Pbx2 is not essential for development and long-term survival.	PBX1 PBX3	2.12e-05	3	93	2	15169896
Pubmed	A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells.	TJP1 CGNL1	2.12e-05	3	93	2	21454477
Pubmed	PAR bZIP-bik is a novel transcriptional pathway that mediates oxidative stress-induced apoptosis in fibroblasts.	DBP TEF	2.12e-05	3	93	2	19219069
Pubmed	The Circadian Clock Gene Bmal1 Controls Intestinal Exporter MRP2 and Drug Disposition.	NFIL3 ABCC2	2.12e-05	3	93	2	31244920
Pubmed	Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression.	DICER1 PDCD4	2.12e-05	3	93	2	25979949
Pubmed	Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival.	MFSD2A TRIT1	2.12e-05	3	93	2	17145094
Pubmed	HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation.	PBX1 PBX3	2.12e-05	3	93	2	11571641
Pubmed	Modulation of the endocrine transcriptional program by targeting histone modifiers of the H3K27me3 mark.	EZH2 NEUROG3	2.12e-05	3	93	2	29530603
Pubmed	Isolation of a novel cDNA that encodes a protein localized to the pre-acrosome region of spermatids.	CEP131 UTP14C	2.12e-05	3	93	2	8529672
Pubmed	Association of polymorphisms and haplotype in the region of TRIT1, MYCL1 and MFSD2A with the risk and clinicopathological features of gastric cancer in a southeast Chinese population.	MFSD2A TRIT1	2.12e-05	3	93	2	23349019
Pubmed	A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing.	RBM15 SPEN	2.12e-05	3	93	2	26190105
Pubmed	The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver.	PBX1 PBX3	2.12e-05	3	93	2	11468159
Pubmed	Functional D-box sequences reset the circadian clock and drive mRNA rhythms.	NFIL3 DBP	2.12e-05	3	93	2	31428688
Pubmed	Induction of pancreatic islet cell differentiation by the neurogenin-neuroD cascade.	NEUROD2 NEUROG3	2.12e-05	3	93	2	17924961
Pubmed	Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2.	EZH2 PDCD4	2.12e-05	3	93	2	28854977
Pubmed	Identification and characterization of mouse plexin B3 promoter.	NEUROG3 PLXNB3	2.12e-05	3	93	2	18680721
Pubmed	A novel pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b.	PBX1 PBX3	2.12e-05	3	93	2	10679934
Pubmed	MicroRNAs of the miR-290-295 Family Maintain Bivalency in Mouse Embryonic Stem Cells.	EZH2 DICER1	2.12e-05	3	93	2	27150236
Pubmed	The loss of circadian PAR bZip transcription factors results in epilepsy.	DBP TEF	2.12e-05	3	93	2	15175240
Pubmed	Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circadian PAR bZip transcription factors DBP, HLF, and TEF.	DBP TEF	2.12e-05	3	93	2	20686175
Pubmed	Functional role of lncRNA MEG3 on pyroptosis through interacting with EZH2 and YTHDC1 in postoperative cognitive dysfunction.	EZH2 YTHDC1	2.12e-05	3	93	2	39236791
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	RBM15 CDC42BPA ARGLU1 MRPL55 PURB ASPH EIF5B MRPS16 MRPL46 YTHDC1	2.15e-05	713	93	10	29802200
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	CEBPE TRPS1 EIF5B XBP1 MCM3 DBP PBX1 TEF EZH2 PBX3 SPEN	2.29e-05	877	93	11	20211142
Pubmed	Mapping the Genetic Landscape of Human Cells.	ARGLU1 EIF5B MCM3 MRPS16 SPAG7 MRPL46 YTHDC1 DICER1	2.92e-05	451	93	8	30033366
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	RBM15 ARID4B NOP16 ARGLU1 NFIL3 ABRAXAS1 ASPH MSL3 PAGR1 SRCAP EZH2 YTHDC1 SPEN	4.04e-05	1294	93	13	30804502
Pubmed	Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export.	RBM15 SPEN	4.23e-05	4	93	2	16129689
Pubmed	Molecular clock is involved in predictive circadian adjustment of renal function.	DBP TEF	4.23e-05	4	93	2	19805330
Pubmed	A promoter in the novel exon of hPPARgamma directs the circadian expression of PPARgamma.	NFIL3 DBP	4.23e-05	4	93	2	20093779
Pubmed	Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.	PBX1 PBX3	4.23e-05	4	93	2	18723445
Pubmed	Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.	ATG16L1 XBP1	4.23e-05	4	93	2	28082357
Pubmed	PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.	PBX1 PBX3	4.23e-05	4	93	2	1682799
Pubmed	Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice.	DBP TEF	4.23e-05	4	93	2	22753645
Pubmed	The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification.	DBP TEF	4.23e-05	4	93	2	16814730
Pubmed	Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity.	DBP TEF	4.23e-05	4	93	2	21383142
Pubmed	Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon.	TJP1 NFIL3 DBP TEF	4.78e-05	74	93	4	26332085
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SPTBN4 DLGAP3 DSCAM ARGLU1 TJP1 PURB NGEF MACF1 MCM3 CEP131 MTCL1	5.34e-05	963	93	11	28671696
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	ARID4B ABRAXAS1 RSF1 SRCAP EZH2	5.34e-05	150	93	5	28242625
Pubmed	Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation.	PBX1 PBX3	7.04e-05	5	93	2	10842069
Pubmed	Bicellular Localization of Tricellular Junctional Protein Angulin-3/ILDR2 Allows Detection of Podocyte Injury.	LSR TJP1	7.04e-05	5	93	2	38311119
Pubmed	Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis.	PBX1 PBX3	7.04e-05	5	93	2	11335119
Pubmed	HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.	PBX1 PBX3	7.04e-05	5	93	2	10082572
Pubmed	m(6)A RNA methylation promotes XIST-mediated transcriptional repression.	RBM15 YTHDC1	7.04e-05	5	93	2	27602518
Pubmed	Transcription factor PBX4 regulates limb development and haematopoiesis in mice.	PBX1 PBX3	7.04e-05	5	93	2	38230761
Pubmed	Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy.	ATG16L1 TJP1 XBP1	7.13e-05	30	93	3	38218976
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	PURB RSF1 EIF5B MCM3 PDCD4	7.92e-05	163	93	5	22113938
Pubmed	Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays.	NFIL3 XBP1 CREB3	9.53e-05	33	93	3	20102225
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	LSR EHBP1L1 TRPM3 PURB TRPS1 RSF1 XBP1 CEP131 MTCL1	9.76e-05	689	93	9	36543142
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ARID4B NFIL3 FOSB TRPS1 EIF5B PBX1 PBX3 YTHDC1 SPEN TTLL7	1.00e-04	857	93	10	25609649
Pubmed	Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification.	EZH2 NEUROG3	1.05e-04	6	93	2	25107471
Pubmed	The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse.	PBX1 PBX3	1.05e-04	6	93	2	10381567
Pubmed	Characterization of TALE genes expression during the first lineage segregation in mammalian embryos.	PBX1 PBX3	1.05e-04	6	93	2	22987645
Pubmed	Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms.	DBP TEF	1.05e-04	6	93	2	33452134
Pubmed	A transcriptional constraint mechanism limits the homeostatic response to activity deprivation in mammalian neocortex.	DBP TEF	1.05e-04	6	93	2	36749029
Pubmed	Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes.	DBP TEF	1.05e-04	6	93	2	32979312
Pubmed	A multipotent progenitor domain guides pancreatic organogenesis.	LSR XBP1 PBX3 NEUROG3	1.07e-04	91	93	4	17609113
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	NEUROD2 CEBPE FOSB XBP1 DBP PBX1 TEF CREB3	1.08e-04	544	93	8	28473536
Pubmed	Human transcription factor protein interaction networks.	CDC42BPA ARID4B NOP16 ATXN7 PURB TRPS1 MARF1 MRPS16 CEP131 PAGR1 PBX1 SRCAP SPEN	1.10e-04	1429	93	13	35140242
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	LSR NEUROD2 TRPS1 XBP1 MACF1 PBX1 PBX3 PLXNA1 CREB3	1.21e-04	709	93	9	22988430
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	RBM15 MYO1E NOP16 ARGLU1 TJP1 PURB ASPH EIF5B MCM3 YTHDC1 SPEN PDCD4	1.32e-04	1257	93	12	36526897
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MYO1E TJP1 CWC27 ZNF330 MARF1 EIF5B MACF1 SPEN DICER1	1.42e-04	724	93	9	36232890
Pubmed	Paneth cells as a site of origin for intestinal inflammation.	ATG16L1 XBP1	1.47e-04	7	93	2	24089213
Pubmed	ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.	ATG16L1 XBP1	1.47e-04	7	93	2	30254094
Pubmed	Circadian clock-coordinated 12 Hr period rhythmic activation of the IRE1alpha pathway controls lipid metabolism in mouse liver.	DBP TEF	1.47e-04	7	93	2	20074527
Pubmed	PBX, MEIS, and IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects.	PBX1 PBX3	1.47e-04	7	93	2	12397630
Pubmed	Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.	ATG16L1 XBP1	1.47e-04	7	93	2	30819965
Pubmed	Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5.	PURB EIF5B EZH2	1.70e-04	40	93	3	21151833
Pubmed	Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.	NFIL3 DBP EZH2	1.70e-04	40	93	3	23555304
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EHBP1L1 CDC42BPA MYO1E MRPL55 CEP131 MRPL46 SRCAP SPEN CTDNEP1 PLXNA1 CREB3	1.79e-04	1105	93	11	35748872
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	RBM15 LSR ARID4B CWC27 MCM3 CEP131 MTCL1 EZH2 PBX3 YTHDC1	1.81e-04	922	93	10	27609421
Pubmed	Blood-Brain Barrier: From Physiology to Disease and Back.	MFSD2A LSR TJP1 ABCC2	1.86e-04	105	93	4	30280653
Interaction	ANKRD50 interactions	ATG16L1 MYO1E RRP36 ARGLU1 CEP131 YTHDC1	9.49e-06	108	91	6	int:ANKRD50
Interaction	MECP2 interactions	RBM15 EHBP1L1 CDC42BPA NOP16 ARGLU1 TJP1 ZNF330 MRPL55 EIF5B MACF1 MCM3 MRPS16 MRPL46 SRCAP EZH2 YTHDC1 SPEN NKAPL	1.51e-05	1287	91	18	int:MECP2
GeneFamily	Basic leucine zipper proteins	CEBPE NFIL3 FOSB XBP1 CREB3	4.47e-07	49	57	5	506
GeneFamily	PAR bZIP family	DBP TEF	2.92e-05	3	57	2	1248
GeneFamily	Plexins	PLXNA1 PLXNB3	3.47e-04	9	57	2	683
GeneFamily	Myosin heavy chains	MYH13 MYH7B	9.99e-04	15	57	2	1098
GeneFamily	Mitochondrial ribosomal proteins	MRPL55 MRPS16 MRPL46	1.98e-03	79	57	3	646
GeneFamily	TALE class homeoboxes and pseudogenes	PBX1 PBX3	3.02e-03	26	57	2	526
Coexpression	FISCHER_G1_S_CELL_CYCLE	NUDT7 ARGLU1 FOSB ASPH MCM3 EZH2 TTLL7	7.38e-06	200	93	7	M107
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARID4B ARGLU1 MACF1 DBP TEF PDCD4 FAM43A	1.72e-07	194	93	7	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARID4B ATXN7 FOSB EIF5B YTHDC1 PDCD4	2.69e-06	187	93	6	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	CDC42BPA ARID4B CCDC146 RSF1 EIF5B PBX1	3.84e-06	199	93	6	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	10x5'-blood-Myeloid_Mac\|blood / Manually curated celltypes from each tissue	DLGAP3 SNX32 ASPH TEF DSE	1.48e-05	148	93	5	1ae2d7475e030e2de49940f3287b02953dbf3c65
ToppCell	10x5'-blood-Myeloid_Mac-Intermediate_macrophages\|blood / Manually curated celltypes from each tissue	DLGAP3 SNX32 ASPH TEF DSE	1.48e-05	148	93	5	b801f38d249a02c4ceceb242cabbbc88418e5fd1
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAM ARGLU1 MYH7B FOSB KIF12	2.57e-05	166	93	5	66026988509e39e41274fa0de738383219e8ff30
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPTBN4 ELL2 NEUROD2 KIF12 NEUROG3	3.14e-05	173	93	5	46ed379571385684145b5cb6dd4ae340ac546e64
ToppCell	COVID-19-kidney-tDL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TRPM3 NGEF KIF12 CGNL1 ABCC2	3.79e-05	180	93	5	864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	DENND2A TRPM3 PBX1 TEF FRMD4B	3.89e-05	181	93	5	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	IIH-mono3-\|IIH / Condition, Cell_class and T cell subcluster	MFSD2A ELL2 MYO1E TJP1 NFIL3	5.54e-05	195	93	5	28a858b04a7b413916c07a8d880f5ea02e985461
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Stem_cells\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	LSR ELL2 TRPM3 MCM3 FAM43A	5.54e-05	195	93	5	2fa0216ba493d9722324c0a9a0c59c40e72b3c4e
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Stem_cells-retina_progenitors\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	LSR ELL2 TRPM3 MCM3 FAM43A	5.54e-05	195	93	5	06a437459717dc3c41ec343b1ec57cf910ecbdd8
ToppCell	IIH-mono3\|IIH / Condition, Cell_class and T cell subcluster	MFSD2A ELL2 MYO1E TJP1 NFIL3	5.54e-05	195	93	5	c6dd5af582d257be64b718e30f60220c1bf1738a
ToppCell	facs-Lung-3m\|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARGLU1 FOSB DBP PDCD4 DSE	5.54e-05	195	93	5	c4648c0332c3826776f9ad3f5f803dbac2b4c0c0
ToppCell	CV-Moderate-6\|CV / Virus stimulation, Condition and Cluster	NFIL3 EIF5B XBP1 MRPS16 CTDNEP1	5.68e-05	196	93	5	7bced0cc2112697593c478fa291b8ed3941fb811
ToppCell	Control-PLT_4\|Control / Disease Group and Platelet Clusters	ARID4B EZH2 FRMD4B PDCD4 TTLL7	5.96e-05	198	93	5	387fd3037fd52e4d4c42de0588767e58af228b59
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	CDC42BPA CCDC146 TJP1 RSF1 PBX1	5.96e-05	198	93	5	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	CDC42BPA ARID4B CCDC146 RSF1 EIF5B	6.10e-05	199	93	5	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	LSR TRPM3 MTCL1 CGNL1 PLXNA1	6.25e-05	200	93	5	2dadf317a42a7e27cc1fac74f91b806c93a57108
Computational	Genes upregulated in subsets of cells of a given type within various tumors	ARGLU1 TJP1 MACF1 SPEN	1.46e-04	50	58	4	GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN
Disease	acute lymphoblastic leukemia (implicated_via_orthology)	DBP TEF EZH2	5.27e-07	6	89	3	DOID:9952 (implicated_via_orthology)
Disease	cholangiocarcinoma (is_implicated_in)	ASPH ABCC2 EZH2	3.92e-05	22	89	3	DOID:4947 (is_implicated_in)
Disease	alcohol dependence measurement, electroencephalogram measurement	FRMD4B DSE	1.87e-04	7	89	2	EFO_0004357, EFO_0007835
Disease	mean platelet volume	MFSD2A MYO1E TRPM3 PURB RSF1 MCM3 SPAG7 TRIM40 PBX1 SRCAP DSE	2.49e-04	1020	89	11	EFO_0004584
Disease	diffuse large B-cell lymphoma (is_marker_for)	EZH2 DICER1	2.49e-04	8	89	2	DOID:0050745 (is_marker_for)
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH13 MYH7B	3.98e-04	10	89	2	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH13 MYH7B	3.98e-04	10	89	2	DOID:0111269 (implicated_via_orthology)
Disease	Focal segmental glomerulosclerosis	MYO1E APOL1	3.98e-04	10	89	2	cv:C0017668
Disease	Inherited focal segmental glomerulosclerosis	MYO1E APOL1	3.98e-04	10	89	2	cv:CN327126
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH13 MYH7B	3.98e-04	10	89	2	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH13 MYH7B	3.98e-04	10	89	2	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH13 MYH7B	3.98e-04	10	89	2	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH13 MYH7B	3.98e-04	10	89	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH13 MYH7B	3.98e-04	10	89	2	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH13 MYH7B	3.98e-04	10	89	2	DOID:0111596 (implicated_via_orthology)
Disease	Hereditary Nephrotic Syndromes, Autosomal Dominant	MYO1E APOL1	4.86e-04	11	89	2	cv:CN043612
Disease	Sodium measurement	MFSD2A RSPH3	4.86e-04	11	89	2	C0337443
Disease	Adverse Event by CTCAE Category	MFSD2A RSPH3	4.86e-04	11	89	2	C1879645
Disease	disease recurrence, colon carcinoma	MACF1 FRMD4B MAP3K4	4.97e-04	51	89	3	EFO_0004952, EFO_1001950
Disease	distal myopathy (implicated_via_orthology)	MYH13 MYH7B	5.82e-04	12	89	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH13 MYH7B	5.82e-04	12	89	2	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH13 MYH7B	6.87e-04	13	89	2	DOID:397 (implicated_via_orthology)
Disease	Familial idiopathic steroid-resistant nephrotic syndrome	MYO1E APOL1	6.87e-04	13	89	2	cv:C4273714
Disease	Malignant neoplasm of liver	NUDT7 NOP16 FOSB DICER1	9.14e-04	142	89	4	C0345904
Disease	Liver neoplasms	NUDT7 NOP16 FOSB DICER1	9.14e-04	142	89	4	C0023903
Disease	distal arthrogryposis (implicated_via_orthology)	MYH13 MYH7B	9.21e-04	15	89	2	DOID:0050646 (implicated_via_orthology)
Disease	total lipids in small VLDL	TDRD15 TRPS1 DBP	1.11e-03	67	89	3	EFO_0022148
Disease	esophagus squamous cell carcinoma (is_marker_for)	PAGR1 EZH2 PBX3	1.47e-03	74	89	3	DOID:3748 (is_marker_for)
Disease	alpha-tocopherol measurement	CFAP20DC MRPL46	1.65e-03	20	89	2	EFO_0007898
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH13 MYH7B DICER1	1.84e-03	80	89	3	DOID:12930 (implicated_via_orthology)
Disease	Etat Marbre	ATXN7 FOSB	2.18e-03	23	89	2	C0266487
Disease	inflammatory bowel disease (implicated_via_orthology)	NFIL3 XBP1	2.58e-03	25	89	2	DOID:0050589 (implicated_via_orthology)
Disease	birth weight, parental genotype effect measurement	MYH7B NFILZ NFIL3 KIF12	2.76e-03	192	89	4	EFO_0004344, EFO_0005939
Disease	peripheral arterial disease, traffic air pollution measurement	TRPS1 MACF1 MCM3 MTCL1	2.86e-03	194	89	4	EFO_0004265, EFO_0007908

Protein segments in the cluster

Peptide	Gene	Start	Entry
QFKRSRLLDTQDKRS	ABRAXAS1	356	Q6UWZ7
NSDERLQNSRAKDRK	ARID4B	911	Q4LE39
AAKDASSVKRRRLNR	AMER2	481	Q8N7J2
ARRFIKLDAQRKRLS	ELL2	566	O00472
KLEESKRARQASRLS	CCDC116	501	Q8IYX3
RKSDARLEQLRDKIR	CCDC187	146	A0A096LP49
SRSEELRKEARQLKR	CWC27	311	Q6UX04
RERNNIAVRKSRDKA	CEBPE	211	Q15744
KDSRRRQARLQKELA	ATG16L1	211	Q676U5
NKKRSRSRSRSRDKE	ARGLU1	21	Q9NWB6
RLNDLNDRDKKNRTA	ANKRD62	61	A6NC57
ADLLKLSLKRRSDRQ	ASPH	416	Q12797
KSAAARRALRSLKAN	DICER1	1901	Q9UPY3
SRALKRRRQSKTNDI	CDC14C	401	A4D256
KRDRKNSASAERDRK	RBM15	716	Q96T37
AKRSREKRRLNDAAI	NFILZ	56	A0A5F9ZHS7
SARSQKREARLDKVL	PAGR1	191	Q9BTK6
QNELERLKESSLKRR	MTCL1	471	Q9Y4B5
LDARRKRRNFNKQAT	PBX1	231	P40424
RRKRRNFSKQATEIL	PBX3	236	P40426
NQLKKRRRLDSDAVN	TRIT1	421	Q9H3H1
ALSKQRRSRRKKAND	NEUROG3	76	Q9Y4Z2
RLRKEKSQLQNSRDL	KIF12	431	Q96FN5
LRQLKRFRRADEVKS	EZH2	26	Q15910
DAETRARNEALRLKK	MYH7B	1651	A7E2Y1
NAKAKRRLRKNSSRD	PDCD4	56	Q53EL6
EKDEQARRQRLRSKL	PLXNA1	1871	Q9UIW2
KAKRTLNDSRLLRED	PLXNB3	1496	Q9ULL4
KLNLRNASSRERRAA	NEK4	36	P51957
RKNNEAAKRSREKRR	NFIL3	81	Q16649
AAKRSREKRRLNDLV	NFIL3	86	Q16649
TDENRRLQRKLARKA	MSL3	76	Q8N5Y2
DLLKKRRSRLRNSSS	EHBP1L1	1281	Q8N3D4
KRRNDQRSRFLALRD	MYCLP1	286	P12525
RKTAERLLRFSDKRQ	DSE	771	Q9UL01
QKARRALQRRQEKSS	ABCC2	251	Q92887
VRNSLLDDAKARLRK	NUDT7	11	P0C024
SNNRKFLNKRLSERE	ATXN7	326	O15265
ERGRSLDDARKRAKQ	MACF1	6541	Q9UPN3
KLAAAKCRNRRRELT	FOSB	166	P53539
VNDLRRKNEKRANRL	MCM3	51	P25205
RRRQNKKALQALRDE	MFSD2A	511	Q8NA29
LDTRTRGRRRSKKQN	FRMD4B	756	Q9Y2L6
QNSERRNFKLLDTRK	DENND2A	426	Q9ULE3
RSGKRNRINTDDRKR	CGNL1	371	Q0VF96
QEARKRLLAAKRAAS	DLGAP3	941	O95886
KDIRALRRARANLQS	APOL1	281	O14791
TSANALAEFKRLKRR	FAM43A	191	Q8N2R8
QRFRLSRDRKVAKSL	HRH3	346	Q9Y5N1
AKNAADDKLRQSLRR	MARF1	421	Q9Y4F3
NEAAKRSRDARRLKE	DBP	266	Q10586
RKIRNKRSAQESRRK	CREB3	156	O43889
RLRSAKELLRREKSN	CROCCP3	56	Q8IVE0
AAARRKKRRRLNDLD	RSF1	1081	Q96T23
KKRRRLNDLDSDSNL	RSF1	1086	Q96T23
KAREEKARQARRAAI	CEP131	326	Q9UPN4
RRALKSEFLVRENRK	PURB	116	Q96QR8
TDSQASRERRLKKNL	LSR	626	Q86X29
SRERRLKKNLALSRE	LSR	631	Q86X29
IRAALRTTERDRKKN	MAP3K4	146	Q9Y6R4
REQRLKRLRDAKSLA	DSCAM	1621	O60469
RRKRAREVLLASQKT	MRPS16	111	Q9Y3D3
DEKNDRTSLNRKLDR	MRPL46	141	Q9H2W6
ERLNRRSRKLRKDIA	TRIM40	116	Q6P9F5
QETRRKAREQAARLK	SPAG7	21	O75391
DALNATARRLRERKS	TDRD15	1326	B5MCY1
KLLTKSQREARARAE	EIF5B	406	O60841
RNSIFNRSIRRKSKA	NGEF	61	Q8N5V2
AAKRSRDARRLKENQ	TEF	246	Q10587
RKLKNRVAAQTARDR	XBP1	76	P17861
RLRSFKDKRLAQSVR	WHAMM	541	Q8TF30
LDSLEEKRKRQRSER	SRCAP	1886	Q6ZRS2
SLRQELRRTERAKKE	CDC42BPA	616	Q5VT25
SVNRKRLNRNARRKA	NOP16	16	Q9Y3C1
SRKQREKERDFRNLR	CCDC146	351	Q8IYE0
DKNNNRRRLRLKSTS	CFAP20DC	231	Q6ZVT6
VADKLDNSRSILKRR	CTDNEP1	141	O95476
KRALASFNQEERRKR	NKAPL	366	Q5M9Q1
NKSKDESQSLLRRRR	TRPS1	876	Q9UHF7
AKAASLARNLAKRRR	RSPH3	6	Q86UC2
NRRKLAERSEASLKV	UTP14C	56	Q5TAP6
LEARKRRFADSNLKA	SPEN	981	Q96T58
ARLRKREAQLQSRKE	MRPL55	91	Q7Z7F7
RKSFSISDKLDRQRN	TRPM3	1676	Q9HCF6
DAEIRSRNDALRLKK	MYH13	1606	Q9UKX3
DKKLRENLRDARNSL	SCFD1	226	Q8WVM8
LRKRELDANRKSSNR	SPTBN4	2426	Q9H254
ENFLSRKRRRNAGKD	RRP36	236	Q96EU6
QRSERNKRLDADRKI	YTHDC1	101	Q96MU7
NKRLDADRKIRLSSS	YTHDC1	106	Q96MU7
GLRSSKRNLRKSRED	TJP1	606	Q07157
KAENRREREKQLRAS	ZNF330	11	Q9Y3S2
KSLASERKRALLSQR	TECRL	6	Q5HYJ1
NKALDKARTRNREVR	SNX32	321	Q86XE0
RRNLAKQKAEAQRRL	TTLL7	386	Q6ZT98
EASDLLLNKKERRRN	MYO1E	721	Q12965
LERSKLRRQKANARE	NEUROD2	116	Q15784