Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cytoplasmic microtubule	KIF18A TEKT2 FAM161A BICD1	1.08e-04	133	39	4	GO:0005881
GeneOntologyCellularComponent	astral microtubule	KIF18A FAM161A	1.85e-04	11	39	2	GO:0000235
GeneOntologyCellularComponent	aster	KIF18A FAM161A	2.21e-04	12	39	2	GO:0005818
GeneOntologyCellularComponent	microtubule organizing center	TSGA10 KIF18A TEKT2 CCDC42 CAMSAP2 FAM161A CEP97 BICD1	2.47e-04	919	39	8	GO:0005815
GeneOntologyCellularComponent	DNA repair complex	ASCC3 KDM1A	8.37e-04	23	39	2	GO:1990391
Domain	-	RBM5 RBM10	1.80e-04	10	38	2	4.10.1060.10
Domain	zf-RanBP	RBM5 RBM10	9.08e-04	22	38	2	PF00641
Domain	G_patch	RBM5 RBM10	9.93e-04	23	38	2	SM00443
Domain	G_patch_dom	RBM5 RBM10	9.93e-04	23	38	2	IPR000467
Domain	ZnF_RBZ	RBM5 RBM10	9.93e-04	23	38	2	SM00547
Domain	G-patch	RBM5 RBM10	9.93e-04	23	38	2	PF01585
Domain	G_PATCH	RBM5 RBM10	9.93e-04	23	38	2	PS50174
Domain	ZF_RANBP2_2	RBM5 RBM10	9.93e-04	23	38	2	PS50199
Domain	ZF_RANBP2_1	RBM5 RBM10	1.08e-03	24	38	2	PS01358
Domain	EF-hand_5	RCN3 MICU1	1.17e-03	25	38	2	PF13202
Domain	Znf_RanBP2	RBM5 RBM10	1.17e-03	25	38	2	IPR001876
Domain	EF-hand_8	RCN3 MICU1	2.17e-03	34	38	2	PF13833
Domain	RRM_1	RBM5 EIF3B RBM10	8.62e-03	208	38	3	PF00076
Domain	Prefoldin	ATP6V0A1 RB1CC1	9.42e-03	72	38	2	IPR009053
Domain	RRM	RBM5 EIF3B RBM10	9.68e-03	217	38	3	SM00360
Domain	RRM_dom	RBM5 EIF3B RBM10	1.09e-02	227	38	3	IPR000504
Domain	RRM	RBM5 EIF3B RBM10	1.13e-02	230	38	3	PS50102
Domain	IQ	DCAF6 CEP97	1.18e-02	81	38	2	SM00015
Domain	-	RBM5 EIF3B RBM10	1.33e-02	244	38	3	3.30.70.330
Domain	IQ_motif_EF-hand-BS	DCAF6 CEP97	1.44e-02	90	38	2	IPR000048
Domain	IQ	DCAF6 CEP97	1.53e-02	93	38	2	PS50096
Domain	Nucleotide-bd_a/b_plait	RBM5 EIF3B RBM10	1.54e-02	258	38	3	IPR012677
Pubmed	RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5.	RBM5 RBM10	1.23e-06	2	39	2	28662214
Pubmed	Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay.	RBM5 RBM10	1.23e-06	2	39	2	28586478
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	CDADC1 KIF18A TEKT2 OCRL DPP8 CAMSAP2 CEP97 FYB2 KDM1A MICU1	1.40e-06	1321	39	10	27173435
Pubmed	Co- and post-transcriptional regulation of Rbm5 and Rbm10 in mouse cells as evidenced by tissue-specific, developmental and disease-associated variation of splice variant and protein expression levels.	RBM5 RBM10	3.67e-06	3	39	2	26784654
Pubmed	RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.	RBM5 RBM10	7.34e-06	4	39	2	24332178
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	RBM5 DCAF6 ATP6V0A1 RBM10 LSM3	6.28e-05	378	39	5	34315543
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RBM5 EIF3B ASCC3 CAMSAP2 KDM1A TADA2B LSM3 MICU1	2.16e-04	1497	39	8	31527615
Pubmed	Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption.	ABCA3 RCN3	2.30e-04	20	39	2	26252542
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	ASCC3 HECW1 TADA2B NCOA5	2.75e-04	281	39	4	24163370
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	ASCC3 RBM10 KDM1A	4.13e-04	129	39	3	23022380
Pubmed	Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.	CEP97 KCTD4	4.23e-04	27	39	2	30404837
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	RBM10 KDM1A TADA2B	4.62e-04	134	39	3	25452129
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	EIF3B OCRL BICD1	5.14e-04	139	39	3	25476789
Pubmed	rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions.	RBM5 RBM10 LSM3	5.47e-04	142	39	3	30217970
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	RBM5 EIF3B ASCC3 RBM10 NCOA5	5.53e-04	605	39	5	28977666
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	RBM5 EIF3B RBM10 LSM3	6.08e-04	347	39	4	16033648
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	RB1CC1 CEP97 NOS1AP	8.75e-04	167	39	3	25659891
Pubmed	Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.	RBM5 EIF3B RB1CC1 ASCC3	8.87e-04	384	39	4	31059266
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	EIF3B RB1CC1 ASCC3 RBM10 KDM1A NCOA5	9.13e-04	1024	39	6	24711643
Pubmed	Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.	CAMSAP2 KDM1A	9.77e-04	41	39	2	15561718
Pubmed	Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.	RBM10 KDM1A RCN3 NCOA5	1.06e-03	403	39	4	35253629
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CAMSAP2 RBM10 MAP3K4 NOS1AP	1.10e-03	407	39	4	12693553
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	RBM5 RBM10	2.66e-04	21	21	2	89
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	RBM5 RBM10	2.93e-04	22	21	2	579
GeneFamily	RNA binding motif containing	RBM5 EIF3B RBM10	1.83e-03	213	21	3	725
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	KIF18A RB1CC1	1.85e-02	181	21	2	694
GeneFamily	EF-hand domain containing	RCN3 MICU1	2.64e-02	219	21	2	863
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-Tfh\|Liver / Manually curated celltypes from each tissue	ABCA3 CAMSAP2 CEP97 CCDC148 NCOA5	2.46e-07	156	39	5	85bc34ff507f9a66c6e3ba7a3ffd5416d0073ccf
ToppCell	ASK452-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	KIF18A OCRL RBM10 VASH2 MACROD2	4.86e-07	179	39	5	c3cf49c069e66db16d2fce1de4c52a4c4fe7e832
Disease	cognitive impairment measurement	CDADC1 MACROD2	1.48e-03	44	38	2	EFO_0007998
Disease	autism	ADCK5 MACROD2	1.75e-03	48	38	2	EFO_0003758
Disease	congestive heart failure (biomarker_via_orthology)	RBM10 NOS1AP	8.41e-03	107	38	2	DOID:6000 (biomarker_via_orthology)
Disease	Drug Use Disorders	ANO4 MACROD2	9.66e-03	115	38	2	C0013222
Disease	Drug Dependence	ANO4 MACROD2	9.66e-03	115	38	2	C1510472
Disease	Drug habituation	ANO4 MACROD2	9.66e-03	115	38	2	C0013170
Disease	Substance Dependence	ANO4 MACROD2	9.66e-03	115	38	2	C0038580
Disease	Substance Use Disorders	ANO4 MACROD2	9.66e-03	115	38	2	C0038586
Disease	Substance-Related Disorders	ANO4 MACROD2	9.66e-03	115	38	2	C0236969
Disease	Drug abuse	ANO4 MACROD2	9.66e-03	115	38	2	C0013146
Disease	Organic Mental Disorders, Substance-Induced	ANO4 MACROD2	9.66e-03	115	38	2	C0029231
Disease	Prescription Drug Abuse	ANO4 MACROD2	9.66e-03	115	38	2	C4316881
Disease	Substance abuse problem	ANO4 MACROD2	9.82e-03	116	38	2	C0740858

Protein segments in the cluster

Peptide	Gene	Start	Entry
LVERRRTMMEDFRKY	EIF3B	746	P55884
ERVKYRQELLERRLM	CCDC148	456	Q8NFR7
RIRMKDEIREYKFRE	BICD1	151	Q96G01
AVVQEKERRLKEYMR	ABCA3	281	Q99758
YVMAEAREKRRMRLV	ADCK5	66	Q3MIX3
MDDKQKDREIRKFRY	CDADC1	381	Q9BWV3
FFRRRKERKEMEELD	DCAF6	686	Q58WW2
KDLRDRMRREKYLIQ	ANO4	911	Q32M45
IERAKARLARYMEEK	CCDC42	196	Q96M95
YKKMLARDERRFRVA	RCN3	161	Q96D15
QMKYRDRAAERREKY	RBM10	811	P98175
VEVVRRKMFIKHYRE	RB1CC1	501	Q8TDY2
MILKVRRDARNFERY	HECW1	986	Q76N89
MLKTRRSYLEKRREE	KIF18A	486	Q8NI77
FRDRKVMEYENRIRA	MICU1	106	Q9BPX6
DKIINYLRERKERLM	NCOA5	361	Q9HCD5
DERIYVKMRNDRELR	LSM3	26	P62310
MERKINRREKEKEYE	KCTD4	1	Q8WVF5
REIRRLMEEIKFKDR	JAKMIP3	206	Q5VZ66
ALELREREMKYRDRA	RBM5	691	P52756
SRRKRAKVEYREMDE	KDM1A	111	O60341
AKDVRYEIRLRRMQE	CEP97	581	Q8IW35
GMYSREEELLRERKR	DPP8	146	Q6V1X1
IVAAMRRIRYEFKAK	NOS1AP	51	O75052
AVRKSEKERMREYQR	FAM161A	526	Q3B820
EKERMREYQRELEER	FAM161A	531	Q3B820
RARREFIRQEYMRRK	CAMSAP2	1226	Q08AD1
RREKFYQRDLEERMV	MROH2A	486	A6NES4
VRLFEEKRYREMRRK	MAP3K4	1301	Q9Y6R4
ERLLKMTLEERRKEY	MACROD2	16	A1Z1Q3
EKMLRAKIRELQRYR	TADA2B	281	Q86TJ2
MKREEKLFRERFKYD	FYB2	646	Q5VWT5
RKRLREMEKVYSELK	TEKT2	266	Q9UIF3
RRYRKVFEDSVRIMD	OCRL	541	Q01968
LMKQYRREEKRIARR	ASCC3	336	Q8N3C0
LDRMEYVRTFRKRED	TMEM121	131	Q9BTD3
RADIRKELEKYARDM	VASH2	276	Q86V25
RDREELKCMLEKYER	TSGA10	31	Q9BZW7
RRCEEMDRKLRFVEK	ATP6V0A1	56	Q93050
EMRKKRYDRKELLLE	WFDC11	26	Q8NEX6