Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionzinc ion binding

ZNF512B BMI1 RBSN NR2E3 TRAFD1 TRIM42 NR2E1 ZNF195 UHRF1 FBXO11 ZNFX1 LHX5 PPARG TRIP4

1.26e-058918114GO:0008270
GeneOntologyMolecularFunctiondiacylglycerol-dependent serine/threonine kinase activity

PRKCE PRKCH PRKCZ

3.47e-0516813GO:0004697
GeneOntologyMolecularFunctiondiacylglycerol-dependent, calcium-independent serine/threonine kinase activity

PRKCE PRKCH

4.86e-053812GO:0004699
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF7 PRAMEF12 PPARG PRAMEF8

7.32e-0555814GO:0042974
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF280A ZNF512B ZNF7 GTF2IRD2B NR2E3 SALL3 DMRT3 NR2E1 GTF2IRD2 ZNF195 ZBTB8A ZNF770 LHX5 PPARG ZNF454 ZNF426

1.50e-0414128116GO:0000981
GeneOntologyMolecularFunctiontransition metal ion binding

ZNF512B BMI1 RBSN NR2E3 TRAFD1 TRIM42 NR2E1 ZNF195 UHRF1 FBXO11 ZNFX1 LHX5 PPARG TRIP4

2.80e-0411898114GO:0046914
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF280A ZNF7 BMI1 NR2E3 SALL3 DMRT3 NR2E1 ZNF195 UHRF1 ZBTB8A ZNF770 PPARG ZNF454 ZNF426

5.48e-0412718114GO:0000987
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

MKRN4P RC3H2 RNF152 UHRF1 FBXO11 LONRF3 RSPRY1 RNF182

6.62e-04473818GO:0004842
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF280A ZNF512B ZNF7 BMI1 NR2E3 SALL3 DMRT3 NR2E1 ZNF195 ZBTB8A ZNF770 LHX5 PPARG ZNF454 ZNF426

6.98e-0414598115GO:0000977
GeneOntologyMolecularFunctionnuclear receptor binding

PRAMEF7 PRAMEF12 PPARG PRAMEF8 TRIP4

9.84e-04187815GO:0016922
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

MKRN4P RC3H2 RNF152 UHRF1 FBXO11 LONRF3 RSPRY1 RNF182

1.10e-03512818GO:0019787
GeneOntologyMolecularFunctionmolecular function activator activity

VEGFC BMI1 RAB3GAP1 COPA RASGRP3 WNT2B ARHGAP29 NBL1 PRKCE WNT4 ARHGAP45 CMC4 ARAP2

1.32e-0312338113GO:0140677
GeneOntologyMolecularFunctionaminoacyltransferase activity

MKRN4P RC3H2 RNF152 UHRF1 FBXO11 LONRF3 RSPRY1 RNF182

1.41e-03532818GO:0016755
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF280A ZNF7 BMI1 NR2E3 SALL3 DMRT3 NR2E1 ZNF195 ZBTB8A ZNF770 PPARG ZNF454 ZNF426

1.43e-0312448113GO:0000978
GeneOntologyMolecularFunctionnuclear receptor activity

NR2E3 NR2E1 PPARG

1.86e-0360813GO:0004879
GeneOntologyMolecularFunctionligand-activated transcription factor activity

NR2E3 NR2E1 PPARG

1.95e-0361813GO:0098531
DomainZF_DAG_PE_1

RASGRP3 DGKK ARHGAP29 PRKCE PRKCH PRKCZ ARHGAP45

1.13e-0864817PS00479
DomainZF_DAG_PE_2

RASGRP3 DGKK ARHGAP29 PRKCE PRKCH PRKCZ ARHGAP45

1.13e-0864817PS50081
DomainC1

RASGRP3 DGKK ARHGAP29 PRKCE PRKCH PRKCZ ARHGAP45

1.26e-0865817SM00109
DomainPE/DAG-bd

RASGRP3 DGKK ARHGAP29 PRKCE PRKCH PRKCZ ARHGAP45

1.40e-0866817IPR002219
DomainC1_1

RASGRP3 DGKK ARHGAP29 PRKCE PRKCH PRKCZ

1.68e-0757816PF00130
DomainZF_RING_1

MKRN4P BMI1 RC3H2 PCGF1 RNF152 TRIM42 UHRF1 LONRF3 RSPRY1 RNF182

5.12e-072918110PS00518
DomainZF_RING_2

MKRN4P BMI1 RC3H2 PCGF1 RNF152 TRIM42 UHRF1 LONRF3 RSPRY1 RNF182

6.36e-072988110PS50089
DomainRING

MKRN4P BMI1 RC3H2 PCGF1 RNF152 TRIM42 UHRF1 LONRF3 RSPRY1 RNF182

7.85e-073058110SM00184
DomainZnf_RING

MKRN4P BMI1 RC3H2 PCGF1 RNF152 TRIM42 UHRF1 LONRF3 RSPRY1 RNF182

1.43e-063268110IPR001841
DomainZnf_C2H2-like

ZNF280A ZNF512B ZNF7 RBSN GTF2IRD2B TRAFD1 SALL3 ZNF781 GTF2IRD2 ZNF195 ZBTB8A ZNF770 ZNF233 ZNF454 ZNF426

1.44e-067968115IPR015880
DomainZnF_C2H2

ZNF280A ZNF512B ZNF7 RBSN GTF2IRD2B TRAFD1 SALL3 ZNF781 GTF2IRD2 ZNF195 ZBTB8A ZNF770 ZNF233 ZNF454 ZNF426

1.73e-068088115SM00355
DomainDAG/PE-bd

RASGRP3 PRKCE PRKCH PRKCZ

1.86e-0621814IPR020454
DomainZnf_RING/FYVE/PHD

BMI1 RC3H2 RBSN PCGF1 RNF152 TRIM42 MTMR3 UHRF1 LONRF3 RSPRY1 RNF182

4.51e-064598111IPR013083
DomainZnf_RING_CS

BMI1 RC3H2 PCGF1 TRIM42 UHRF1 LONRF3 RNF182

6.85e-06163817IPR017907
DomainZnf_C2H2

ZNF280A ZNF512B ZNF7 RBSN TRAFD1 SALL3 ZNF781 ZNF195 ZBTB8A ZNF770 ZNF233 ZNF454 ZNF426

4.01e-058058113IPR007087
Domainzf-C3HC4

MKRN4P BMI1 PCGF1 RNF152 TRIM42 LONRF3 RNF182

5.17e-05223817PF00097
DomainPUA-like_domain

UHRF1 LONRF3 TRIP4

7.24e-0519813IPR015947
DomainPRAME_family

PRAMEF7 PRAMEF12 PRAMEF8

7.24e-0519813IPR026271
Domain-

GTF2IRD2B GTF2IRD2

1.11e-0448123.90.1460.10
DomainGTF2I

GTF2IRD2B GTF2IRD2

1.11e-044812PS51139
DomainGTF2I

GTF2IRD2B GTF2IRD2

1.11e-044812PF02946
DomainGTF2I

GTF2IRD2B GTF2IRD2

1.11e-044812IPR004212
DomainProt_kin_PKC_delta

PRKCE PRKCH

1.11e-044812IPR014376
DomainZINC_FINGER_C2H2_2

ZNF280A ZNF512B ZNF7 RBSN SALL3 ZNF781 ZNF195 ZBTB8A ZNF770 ZNF233 ZNF454 ZNF426

1.22e-047758112PS50157
DomainZINC_FINGER_C2H2_1

ZNF280A ZNF512B ZNF7 RBSN SALL3 ZNF781 ZNF195 ZBTB8A ZNF770 ZNF233 ZNF454 ZNF426

1.25e-047778112PS00028
Domain-

RC3H2 RBSN PCGF1 RNF152 MTMR3 UHRF1 LONRF3 RSPRY1 RNF182

1.40e-044498193.30.40.10
DomainMACPF_2

MPEG1 C8A

3.85e-047812PS51412
DomainMACPF_1

MPEG1 C8A

3.85e-047812PS00279
DomainPkinase_C

PRKCE PRKCH PRKCZ

5.49e-0437813IPR017892
DomainRho_GTPase_activation_prot

PLXNC1 ARHGAP29 ARHGAP45 ARAP2

5.81e-0488814IPR008936
Domain-

ZNF280A ZNF7 SALL3 ZNF781 ZNF195 ZBTB8A ZNF770 ZNF233 ZNF454 ZNF426

6.92e-0467981103.30.160.60
DomainPkinase_C

PRKCE PRKCH PRKCZ

7.99e-0442813PF00433
DomainRetinoid-X_rcpt/HNF4

NR2E3 NR2E1

8.17e-0410812IPR000003
DomainZnf_C2H2/integrase_DNA-bd

ZNF280A ZNF7 SALL3 ZNF781 ZNF195 ZBTB8A ZNF770 ZNF233 ZNF454 ZNF426

8.18e-046948110IPR013087
DomainZnf_C3HC4_RING-type

BMI1 PCGF1 RNF152 LONRF3 RNF182

9.10e-04172815IPR018957
DomainMACPF

MPEG1 C8A

9.96e-0411812PF01823
Domainzf-C4

NR2E3 NR2E1 PPARG

1.04e-0346813PF00105
DomainZnf_hrmn_rcpt

NR2E3 NR2E1 PPARG

1.04e-0346813IPR001628
DomainNuclear_hrmn_rcpt

NR2E3 NR2E1 PPARG

1.04e-0346813IPR001723
DomainNUCLEAR_REC_DBD_2

NR2E3 NR2E1 PPARG

1.04e-0346813PS51030
DomainNUCLEAR_REC_DBD_1

NR2E3 NR2E1 PPARG

1.04e-0346813PS00031
DomainZnF_C4

NR2E3 NR2E1 PPARG

1.04e-0346813SM00399
Domain-

NR2E3 NR2E1 PPARG

1.11e-03478131.10.565.10
DomainHOLI

NR2E3 NR2E1 PPARG

1.18e-0348813SM00430
DomainNucl_hrmn_rcpt_lig-bd

NR2E3 NR2E1 PPARG

1.18e-0348813IPR000536
DomainHormone_recep

NR2E3 NR2E1 PPARG

1.18e-0348813PF00104
DomainMACPF

MPEG1 C8A

1.19e-0312812SM00457
DomainMACPF

MPEG1 C8A

1.19e-0312812IPR020864
DomainAGC-kinase_C

PRKCE PRKCH PRKCZ

1.85e-0356813IPR000961
DomainAGC_KINASE_CTER

PRKCE PRKCH PRKCZ

1.85e-0356813PS51285
DomainS_TK_X

PRKCE PRKCH PRKCZ

1.85e-0356813SM00133
Domain-

NR2E3 NR2E1 PPARG

1.94e-03578133.30.50.10
DomainZnf_NHR/GATA

NR2E3 NR2E1 PPARG

2.04e-0358813IPR013088
DomainRhoGAP

ARHGAP29 ARHGAP45 ARAP2

2.47e-0362813SM00324
DomainRhoGAP

ARHGAP29 ARHGAP45 ARAP2

2.59e-0363813PF00620
DomainRHOGAP

ARHGAP29 ARHGAP45 ARAP2

2.71e-0364813PS50238
DomainRhoGAP_dom

ARHGAP29 ARHGAP45 ARAP2

2.71e-0364813IPR000198
Domain-

ARHGAP29 ARHGAP45 ARAP2

2.71e-03648131.10.555.10
DomainWnt

WNT2B WNT4

3.03e-0319812IPR005817
DomainWnt_CS

WNT2B WNT4

3.03e-0319812IPR018161
Domainwnt

WNT2B WNT4

3.03e-0319812PF00110
DomainWNT1

WNT2B WNT4

3.03e-0319812SM00097
DomainWNT1

WNT2B WNT4

3.03e-0319812PS00246
Domainzf-C2H2

ZNF7 SALL3 ZNF781 ZNF195 ZBTB8A ZNF770 ZNF233 ZNF454 ZNF426

3.05e-03693819PF00096
DomainRNaseH-like_dom

GTF2IRD2B GTF2IRD2 PAN2

3.35e-0369813IPR012337
PathwayWP_WNT_SIGNALING

WNT2B PRKCE PRKCH PRKCZ WNT4

3.78e-0661555MM15893
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

WNT2B PRKCE PRKCH PRKCZ WNT4 PPARG

6.28e-06118556M39852
PathwayWP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY

WNT2B PRKCE PRKCH PRKCZ WNT4

4.47e-05101555MM15829
PathwayWP_WNT_SIGNALING_AND_PLURIPOTENCY

WNT2B PRKCE PRKCH PRKCZ WNT4

4.47e-05101555M39387
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

DGKK PRKCE PRKCH

1.22e-0425553MM14511
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

DGKK PRKCE PRKCH

1.54e-0427553M12123
PathwayPID_RAS_PATHWAY

RASGRP3 PRKCE PRKCZ

2.12e-0430553M269
Pubmed

Differentiation of nonbeating embryonic stem cells into beating cardiomyocytes is dependent on downregulation of PKC beta and zeta in concert with upregulation of PKC epsilon.

PRKCE PRKCH PRKCZ

5.04e-08482312648500
Pubmed

Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states.

PRKCE PRKCH PRKCZ

5.04e-0848238670164
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF7 UHRF1 PRAMEF12 PRAMEF8

1.08e-071982428604677
Pubmed

Protein kinase C(mu) regulation of the JNK pathway is triggered via phosphoinositide-dependent kinase 1 and protein kinase C(epsilon).

PRKCE PRKCH PRKCZ

1.26e-07582312223477
Pubmed

Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta.

PRKCE PRKCH PRKCZ

2.51e-0768238621384
Pubmed

Platelet P-selectin expression: requirement for protein kinase C, but not protein tyrosine kinase or phosphoinositide 3-kinase.

PRKCE PRKCH PRKCZ

2.51e-07682312783114
Pubmed

Distribution of the extended family of protein kinase C isoenzymes in fetal organs of mice: an immunohistochemical study.

PRKCE PRKCH PRKCZ

7.01e-0788237606770
Pubmed

aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.

PRKCE PRKCH PRKCZ

1.05e-06982317203073
Pubmed

Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein.

PRKCE PRKCH PRKCZ

1.05e-0698237850771
Pubmed

Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report.

PRKCE PRKCH PRKCZ

1.05e-0698238206685
Pubmed

Regulation of HIV-1 gag protein subcellular targeting by protein kinase C.

PRKCE PRKCH PRKCZ

1.05e-0698237876252
Pubmed

Phosphorylation of HIV-1 gag proteins by protein kinase C.

PRKCE PRKCH PRKCZ

1.05e-0698238473314
Pubmed

The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway.

PRKCE PRKCH PRKCZ

1.50e-06108231970444
Pubmed

Human immunodeficiency virus induces phosphorylation of its cell surface receptor.

PRKCE PRKCH PRKCZ

1.50e-06108233259291
Pubmed

Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates.

PRKCE PRKCH PRKCZ

1.50e-061082310491200
Pubmed

Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41.

PRKCE PRKCH PRKCZ

1.50e-06108232139676
Pubmed

Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol.

PRKCE PRKCH PRKCZ

2.06e-061182314613966
Pubmed

IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C.

PRKCE PRKCH PRKCZ

2.06e-06118238599832
Pubmed

Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.

PRKCE PRKCH PRKCZ

2.06e-06118232182321
Pubmed

In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46.

PRKCE PRKCH PRKCZ

2.06e-06118238914829
Pubmed

Expression profile of protein kinase C isozymes in preimplantation mouse development.

PRKCE PRKCH PRKCZ

2.06e-061182316183862
Pubmed

Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium.

PRKCE PRKCH PRKCZ

2.74e-061282311141237
Pubmed

HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?

PRKCE PRKCH PRKCZ

2.74e-061282318577246
Pubmed

c-FLIPL regulates PKC via AP-2 to inhibit Bax-mediated apoptosis induced by HIV-1 gp120 in Jurkat cells.

PRKCE PRKCH PRKCZ

2.74e-061282319363595
Pubmed

HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta.

PRKCE PRKCH PRKCZ

2.74e-061282311919157
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF7 MKRN4P JARID2 NR2E3 SALL3 PLXNC1 NR2E1 ZNF195 UHRF1 ZBTB8A ZNF426

3.11e-06808821120412781
Pubmed

HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system.

PRKCE PRKCH PRKCZ

3.55e-061382310641798
Pubmed

The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.

PRKCE PRKCH PRKCZ

3.55e-06138238948582
Pubmed

EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland.

PRKCE PRKCH PRKCZ

3.55e-061382312761849
Pubmed

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.

PRAMEF7 REC114 PRAMEF12 PRAMEF8

4.34e-064682417287250
Pubmed

HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells.

PRKCE PRKCH PRKCZ

4.51e-06148237642615
Pubmed

[Correlation between PPARgamma and VEGF-C expression in extrahepatic cholangioadenocarcinoma (EHCAC) and their prognostic significance].

VEGFC PPARG

5.49e-06282220021832
Pubmed

Novel modulating effects of PKC family genes on the relationship between serum vitamin D and relapse in multiple sclerosis.

PRKCH PRKCZ

5.49e-06282223868949
Pubmed

UHRF1 Promotes Proliferation of Human Adipose-Derived Stem Cells and Suppresses Adipogenesis via Inhibiting Peroxisome Proliferator-Activated Receptor γ.

UHRF1 PPARG

5.49e-06282231428652
Pubmed

Role of protein kinase C and mitochondrial permeability transition pore in the neuroprotective effect of ceramide in ischemia-induced cell death.

PRKCE PRKCZ

5.49e-06282221081127
Pubmed

UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression.

UHRF1 PPARG

5.49e-06282222286757
Pubmed

Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.

GTF2IRD2B GTF2IRD2

5.49e-06282215388857
Pubmed

Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes.

PRKCE PRKCH PRKCZ

5.63e-06158238627654
Pubmed

Association of CPI-17 with protein kinase C and casein kinase I.

PRKCE PRKCH PRKCZ

5.63e-061582315003508
Pubmed

HIV envelope gp120 activates human arterial smooth muscle cells.

PRKCE PRKCH PRKCZ

5.63e-061582311504923
Pubmed

A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.

PRKCE PRKCH PRKCZ

6.92e-06168231832084
Pubmed

[HIV-1 Tat protein induces IL-10 production by human monocytes: implications of the PKC and calcium pathway].

PRKCE PRKCH PRKCZ

6.92e-061682311833470
Pubmed

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

MKRN4P BMI1 JARID2 PRAMEF7 PRAMEF12 LHX5 WNT4 PRAMEF8

7.41e-0642482821731673
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF7 PRAMEF12 PRAMEF8

8.39e-061782323565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF7 PRAMEF12 PRAMEF8

8.39e-061782337781892
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF7 PRAMEF12 PRAMEF8

1.00e-051882323894331
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF7 PRAMEF12 PRAMEF8

1.00e-051882312890732
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF7 PRAMEF12 PRAMEF8

1.00e-051882329731491
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF7 PRAMEF12 PRAMEF8

1.00e-051882314675769
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF7 PRAMEF12 PRAMEF8

1.00e-051882339181896
Pubmed

Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway.

PRKCE PRKCH PRKCZ

1.40e-052082311044099
Pubmed

Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.

ZNF7 ZNF195 ZNF426

1.40e-05208237479878
Pubmed

Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.

ZNF7 ZNF195 ZNF426

1.40e-05208232542606
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF7 PRAMEF12 PRAMEF8

1.40e-052082326694250
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF7 PRAMEF12 PRAMEF8

1.40e-052082316580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF7 PRAMEF12 PRAMEF8

1.40e-052082321425410
Pubmed

Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.

PRKCE PRKCH PRKCZ

1.63e-05218239446795
Pubmed

The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.

PRKCE PRKCH PRKCZ

1.63e-052182322114277
Pubmed

Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways.

PRKCE PRKCH PRKCZ

1.63e-05218239671211
Pubmed

Long noncoding RNA SNHG12 induces proliferation, migration, epithelial-mesenchymal transition, and stemness of esophageal squamous cell carcinoma cells via post-transcriptional regulation of BMI1 and CTNNB1.

BMI1 SNHG12

1.64e-05382232239639
Pubmed

Isoforms of protein kinase C and their distribution in human adrenal cortex and tumors.

PRKCE PRKCZ

1.64e-05382211740573
Pubmed

Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms.

PRKCE PRKCZ

1.64e-05382221338602
Pubmed

Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.

GTF2IRD2B GTF2IRD2

1.64e-05382215100712
Pubmed

A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin.

PRKCE PRKCH

1.64e-0538222266135
Pubmed

Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation.

MKRN4P PPARG

1.64e-05382224336050
Pubmed

Upregulation of PKCη by PKCε and PDK1 involves two distinct mechanisms and promotes breast cancer cell survival.

PRKCE PRKCH

1.64e-05382223562764
Pubmed

Highly conserved non-coding sequences and the 18q critical region for short stature: a common mechanism of disease?

SALL3 CHRDL1

1.64e-05382218213369
Pubmed

Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesis.

WNT2B WNT4

1.64e-05382211507767
Pubmed

Direct interaction of the beta-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes.

PRKCH PRKCZ

1.64e-05382210491320
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF7 PRAMEF12 PRAMEF8

1.88e-052282331729367
Pubmed

HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.

PRKCE PRKCH PRKCZ

1.88e-052282311154208
Pubmed

The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.

PRKCE PRKCH PRKCZ

1.88e-05228239151826
Pubmed

A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

NR2E3 NR2E1 PPARG

1.88e-052282323975195
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF7 PRAMEF12 PRAMEF8

2.16e-052382319480014
Pubmed

Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

PRKCE PRKCH PRKCZ

2.47e-052482310843712
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

PRAMEF7 RASGRP3 FBXO11 PRAMEF12 PPARG PRAMEF8 ZNF426

2.47e-0536382714691545
Pubmed

Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120.

PRKCE PRKCH PRKCZ

2.80e-052582315689238
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF7 PRAMEF12 PRAMEF8

2.80e-052582337451217
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF7 PRAMEF12 PRAMEF8

2.80e-052582312620990
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF7 PRAMEF12 PRAMEF8

3.16e-052682318500982
Pubmed

Protein kinase C regulates human pluripotent stem cell self-renewal.

PRKCE PRKCZ

3.28e-05482223349801
Pubmed

Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts.

PRKCE PRKCZ

3.28e-05482222232556
Pubmed

Effects of the antiandrogen flutamide on the expression of protein kinase C isoenzymes in LNCaP and PC3 human prostate cancer cells.

PRKCE PRKCZ

3.28e-05482215499829
Pubmed

Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1.

PRKCE PRKCZ

3.28e-05482218296444
Pubmed

Dual Regulation of Spine-Specific and Synapse-to-Nucleus Signaling by PKCδ during Plasticity.

PRKCE PRKCH

3.28e-05482237277178
Pubmed

Phosphorylation of Nanog is essential to regulate Bmi1 and promote tumorigenesis.

BMI1 PRKCE

3.28e-05482223708658
Pubmed

De novo mutation in RING1 with epigenetic effects on neurodevelopment.

BMI1 PCGF1

3.28e-05482229386386
Pubmed

TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.

GTF2IRD2B GTF2IRD2

3.28e-05482217823943
Pubmed

Evolution of general transcription factors.

GTF2IRD2B GTF2IRD2

3.28e-05482223229069
Pubmed

Canonical WNT signaling during kidney development.

WNT2B WNT4

3.28e-05482217494089
Pubmed

GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.

GTF2IRD2B GTF2IRD2

3.28e-05482222899722
Pubmed

Expression of protein kinase C isoforms and interleukin-1beta in myofibrillar myopathy.

PRKCH PRKCZ

3.28e-05482215159477
Pubmed

A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells.

PRKCE PRKCH

3.28e-05482221602810
Pubmed

The Par6alpha/aPKC complex regulates Akt1 activity by phosphorylating Thr34 in the PH-domain.

PRKCH PRKCZ

3.28e-05482217335965
Pubmed

Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs.

PRKCE PRKCH

3.28e-05482234593629
Pubmed

Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.

GTF2IRD2B GTF2IRD2

3.28e-05482221328569
Pubmed

Protein kinase C as a tumor suppressor.

PRKCE PRKCZ

3.28e-05482228476658
Pubmed

The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.

RNF152 RNF182

3.28e-05482232486221
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

JARID2 PRAMEF7 RBSN TRAFD1 MRNIP PRAMEF12 PRKCZ LONRF3 PRAMEF8 ARMH3 AMZ2 ARAP2

3.37e-051242821230973865
Pubmed

Role of phosphorylation in the nuclear biology of HIV-1.

PRKCE PRKCH PRKCZ

3.55e-052782321651489
Cytoband1p36.21

PRAMEF7 PRAMEF12 PRAMEF8

2.02e-04638231p36.21
GeneFamilyRing finger proteins

MKRN4P BMI1 RC3H2 PCGF1 RNF152 TRIM42 UHRF1 LONRF3 RSPRY1 RNF182

1.83e-08275591058
GeneFamilyPRAME family

PRAMEF7 PRAMEF12 PRAMEF8

6.36e-0524593686
GeneFamilyRing finger proteins|Polycomb group ring fingers

BMI1 PCGF1

2.18e-04759261
GeneFamilyC2 domain containing protein kinases

PRKCE PRKCH

4.63e-0410592835
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF7 SALL3 ZNF781 ZNF195 ZBTB8A ZNF770 ZNF233 ZNF454 ZNF426

4.95e-0471859928
GeneFamilyNuclear hormone receptors

NR2E3 NR2E1 PPARG

5.47e-044959371
GeneFamilyWnt family|Endogenous ligands

WNT2B WNT4

1.73e-0319592360
GeneFamilyZinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors

RBSN MTMR3

4.58e-033159281
CoexpressionHEVNER_CORTEX_NEURAL_STEM_CELLS

VEGFC SALL3 NR2E1

1.31e-0515823MM406
CoexpressionHUANG_GATA2_TARGETS_DN

PRAMEF7 NT5C3A ARHGAP29 PRAMEF12 PRAMEF8

1.43e-0598825MM942
CoexpressionAtlasdev gonad_e13.5_F_SupCellPrec_Sry_k-means-cluster#3_top-relative-expression-ranked_1000

RNF152 ETFDH ARHGAP29 OCIAD2 PHOSPHO2 WNT4 RYR2 ARAP2

7.37e-06281768gudmap_dev gonad_e13.5_F_SupCellPrec_Sry_k3_1000
CoexpressionAtlasdev gonad_e12.5_F_SupCellPrec_Sry_k-means-cluster#2_top-relative-expression-ranked_200

RNF152 ARHGAP29 OCIAD2 RYR2

4.50e-0555764gudmap_dev gonad_e12.5_F_SupCellPrec_Sry_k2_200
Drugaplysiatoxin

CHRDL1 PRKCE PRKCH PRKCZ

3.00e-0628824CID000040465
DrugPolychlorinated biphenyls

CHRDL1 PRKCE PRKCH PRKCZ

3.47e-0629824CID000006636
Drugethoxytriethyleneglycol

VEGFC NR2E3 PRKCE PRKCH PRKCZ

4.03e-0666825CID000008190
Drugstrontium

TRPM7 PRKCE PRKCH PRKCZ RYR2

4.67e-0668825CID000104798
Drugnorathyriol

PRKCE PRKCH PRKCZ PPARG

9.43e-0637824CID005281656
DrugFura-2AM

TRPM7 NBL1 PRKCE PRKCH RYR2

9.80e-0679825CID000105091
DrugAC1LDMDX

PRKCE PRKCH PRKCZ PPARG

1.73e-0543824CID000621355
Drugdansyl-DAG

PRKCE PRKCH PRKCZ

1.99e-0515823CID000129493
DrugRK-1409B

PRKCE PRKCH PRKCZ

1.99e-0515823CID003036125
Drugprocyanidin B2

CHRDL1 PRKCE PRKCH PRKCZ

2.08e-0545824CID000122738
Drugdaphnoretin

PRKCE PRKCH PRKCZ

2.95e-0517823CID005281406
Drugdihydrosterculic acid

PRKCE PRKCH PRKCZ

3.53e-0518823CID000160788
Drugsevoflurane

COPA NBL1 PRKCE PRKCH PRKCZ

3.90e-05105825CID000005206
DrugTAPP-Br

PRKCE PRKCH PRKCZ

4.19e-0519823CID000160326
Drugphosphine oxide

NBL1 PRKCE PRKCH PRKCZ RYR2

4.27e-05107825CID000166931
DrugKS-619-1

PRKCE PRKCH PRKCZ

5.71e-0521823CID000128369
DrugK-259-2

PRKCE PRKCH PRKCZ

5.71e-0521823CID006438946
Drugbroussochalcone A

PRKCE PRKCH PRKCZ

5.71e-0521823CID006438825
DrugChlorprothixene hydrochloride [6469-93-8]; Up 200; 11.4uM; PC3; HT_HG-U133A

ZNF280A PLXNC1 MTMR3 ARC MRNIP C8A

7.45e-051958266692_UP
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

ZNF7 JARID2 ARHGAP29 UHRF1 PPARG ARHGAP45

2.65e-05239726EFO_0010934
Diseasepulse pressure measurement

RC3H2 TRPM7 TTC16 PLXNC1 WNT2B ETFDH FAM76B UHRF1 PRKCE PPARG ARMH3 INTS8

1.29e-0413927212EFO_0005763
DiseaseMetabolic Diseases

ETFDH PPARG

2.61e-0410722C0025517
DiseaseColorectal Carcinoma

SALL3 TRPM7 ETFDH PAN2 PRKCE PRKCZ PPARG RNF182

3.09e-04702728C0009402
DiseaseCognitive impairment

NAALADL2 RYR2

3.18e-0411722HP_0100543
DiseaseFEV/FEC ratio

VEGFC REC114 ZNF781 RASGRP3 MTMR3 CHRDL1 PRKCE WNT4 PPARG ARAP2

7.71e-0412287210EFO_0004713
Diseasehematocrit

VEGFC NR2E3 NT5C3A DGKK MTMR3 CHRDL1 PRKCE PPARG RNF182

7.72e-041011729EFO_0004348
Diseasediastolic blood pressure, systolic blood pressure

ZNF512B REC114 PLXNC1 PRKCE FBXO11 PPARG RYR2

1.24e-03670727EFO_0006335, EFO_0006336
Diseasehip circumference

TRAFD1 TRPM7 FAM76B DNAJC27 PRKCH

1.43e-03338725EFO_0005093
Diseaseaspartate aminotransferase measurement

VEGFC TRAFD1 TRPM7 ETFDH ARHGAP29 FAM76B PPARG ARHGAP45

1.59e-03904728EFO_0004736
Diseasecerebral amyloid deposition measurement

WNT2B PRKCE ARHGAP45

1.64e-0395723EFO_0007707
Diseasebreast carcinoma (is_implicated_in)

VEGFC FBXO11

1.70e-0325722DOID:3459 (is_implicated_in)
Diseaseserum non-albumin protein measurement

RASGRP3 MTMR3 ARHGAP29 PPARG ARHGAP45

1.91e-03361725EFO_0004568
Diseaseacute kidney failure (implicated_via_orthology)

WNT4 PPARG

1.98e-0327722DOID:3021 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
CHENTKNLLCLFCLK

ZNF280A

416

P59817
KRCPTCHNIIDNCKL

NT5C3A

101

Q9H0P0
QCKETGRCLKRHLVC

C8A

101

P07357
IKACLCRCQETIANL

ARC

91

Q7LC44
CIQVVHKLLCYQKKC

ARMH3

471

Q5T2E6
CVVICKKCAGQHRSL

ARAP2

716

Q8WZ64
CLSLEKLVNEHKCLC

ARL13B

146

Q3SXY8
KLVNEHKCLCQIEPC

ARL13B

151

Q3SXY8
LNLCPICLHKLQCAV

AMZ2

286

Q86W34
ILSNCNHTFCLKCIR

MKRN4P

336

Q13434
TVCKTCLNKLHRKAC

RC3H2

36

Q9HBD1
KEQALEHCCSCVQKL

REC114

126

Q7Z4M0
CLLHQKLQMLNCCIE

RAB3GAP1

511

Q15042
HRNQCQACRLKKCLQ

NR2E3

96

Q9Y5X4
CCTHCKDTLLKREQQ

RBSN

251

Q9H1K0
IKRMIKCCSLLNCHT

INTS8

881

Q75QN2
KCCSLLNCHTQVAIL

INTS8

886

Q75QN2
HNRHCLLTCEECKIK

OCIAD2

126

Q56VL3
HRKCTLLVFCKTVCE

MPEG1

436

Q2M385
RCCSCRLFQAHQVKK

MRNIP

11

Q6NTE8
VRCLIQNHLCQKEFC

PAN2

541

Q504Q3
IICEVCKVKSHRLCA

DGKK

356

Q5KSL6
CCLACHKKCLETLAI

ARHGAP45

731

Q92619
VCANKIDCTKHRCVD

DNAJC27

131

Q9NZQ0
CVVHKRCHELIITKC

PRKCE

206

Q02156
LQCKVCKMNVHRRCE

PRKCE

271

Q02156
IIECLHSFCKTCIVR

BMI1

31

P35226
RVANCNKHKSCSECL

PLXNC1

451

O60486
EPKRSCCRCHQKVRQ

FAM205A

41

Q6ZU69
QLCKECRIAHPIVKC

FAM76B

26

Q5HYJ3
HIKCVQCCECKTNLS

LHX5

26

Q9H2C1
LVEKILHCSCQACGK

NBL1

111

P41271
EELIALCQKSLKCCR

DEFB106A

41

Q8N104
THSCNRCPKNLCKKV

PHOSPHO2

141

Q8TCD6
QRKGLLHVCCKELQI

PRAMEF12

171

O95522
CLLVCHRKCLENLVI

ARHGAP29

641

Q52LW3
INAQNCVHCKTCDIK

ETFDH

581

Q16134
KHQLVRDSCKASCNC

CRISP3

226

P54108
VLCTCNVTKQECKKI

CHRDL1

286

Q9BU40
RNAICVNCIKKCHQG

FBXO11

861

Q86XK2
KDCTCEKCILIIERQ

DMRT3

51

Q9NQL9
IVICNRKLDALCNIH

COPA

511

P53621
ICCIIHPESLCAQKL

GTF2IRD2

651

Q86UP8
ICCIIHPESLCAQKL

GTF2IRD2B

651

Q6EKJ0
QRKGLLHVCCKELQV

PRAMEF8

171

Q5VWM4
CVICHRVLSCQSALK

SALL3

681

Q9BXA9
RNHKVLDVLCSLCVC

RYR2

606

Q92736
CRDIFQLHLTCKDCK

MTMR3

81

Q13615
QLHLTCKDCKVIRCQ

MTMR3

86

Q13615
HRNQCRACRLKKCLE

NR2E1

66

Q9Y466
VKIKDLNEHIVCCLC

PCGF1

36

Q9BSM1
CLRNQEVKRALCCTL

OR6A2

296

O95222
CLECALRHVEKQKSC

JARID2

1161

Q92833
CNHSLCEKCLRQLQK

TRIM42

161

Q8IWZ5
LLKQVSIRENCCSLC

RSPRY1

516

Q96DX4
KLLDCKHTCCSVCLQ

RNF152

26

Q8N8N0
CFKIHVTCKAVLICD

SNHG12

26

Q9BXW3
AAEHCQVTCKCNKKL

TRAFD1

56

O14545
IKAFLRKTECHCQIV

LCMT1

81

Q9UIC8
NCHKQCKDLLVLACR

RASGRP3

531

Q8IV61
CDLNCRIHKKSRNKC

PPARG

176

P37231
QRKPKVLECCHRVCA

RNF182

31

Q8N6D2
SKCQAVIQELRKCCA

CMC4

26

P56277
QRKGLLHVCCKELQV

PRAMEF7

171

Q5VXH5
PHKELDRNSCQCVCK

VEGFC

306

P49767
TIHQACKLICRKCKR

ZBTB8A

331

Q96BR9
QLSCKICIRQLKGHE

UNC5D

801

Q6UXZ4
ENIRTRHKICPCDKC

ZNF770

466

Q6IQ21
KRLLICSHKCQEPCI

ZNFX1

1466

Q9P2E3
EVCQKLQDALKCQHC

ZNF512B

531

Q96KM6
SCKHCKDDVNRLCRV

UHRF1

301

Q96T88
SRCQQIDVKNKLCKC

ZNF233

196

A6NK53
IDVKNKLCKCDHCVR

ZNF233

201

A6NK53
KLCKCDHCVRQRIAH

ZNF233

206

A6NK53
KCNICEKAFVCRAHL

ZNF454

301

Q8N9F8
VKCRQCQRLVELHTC

WNT4

336

P56705
CMACLLALKQHQACL

TTC16

176

Q8NEE8
QKHKLINNCLICGRI

TRIP4

176

Q15650
CGKVFICCSTLIQHK

ZNF781

66

Q8N8C0
LRTHTEEKACECKIC

ZNF426

411

Q9BUY5
SHIVSLFCCICKRRK

TRPM7

1136

Q96QT4
KCQECNNVIKTCSVL

ZNF195

301

O14628
RCKECRNTVDVHTCK

WNT2B

366

Q93097
KISRCQECQKKLSDC

ZNF7

221

P17097
ECKLQTCKRSHQLIH

ZC3HAV1L

201

Q96H79
CKICKMNVHIRCQAN

PRKCH

276

P24723
CINCKLLVHKRCHGL

PRKCZ

161

Q05513
FCLKCLERCLDHNAK

LONRF3

486

Q496Y0
KSNRCNFCHVLKILC

NAALADL2

116

Q58DX5