Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

TBXAS1 DPYD

6.96e-0434232GO:0016628
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors

TBXAS1 DPYD

2.30e-0362232GO:0016627
GeneOntologyMolecularFunctioncysteine-type endopeptidase activity

BLMH USP1

4.37e-0386232GO:0004197
GeneOntologyMolecularFunctionflavin adenine dinucleotide binding

NOX4 DPYD

5.20e-0394232GO:0050660
GeneOntologyMolecularFunctionphosphoric diester hydrolase activity

PDE6B FAN1

5.53e-0397232GO:0008081
GeneOntologyBiologicalProcessnon-proteinogenic amino acid metabolic process

BLMH NOX4 DPYD

1.05e-0487223GO:0170041
GeneOntologyBiologicalProcesshomocysteine metabolic process

BLMH NOX4

1.13e-0415222GO:0050667
GeneOntologyBiologicalProcessresponse to xenobiotic stimulus

BLMH FANCB DPYD PARP4 CTPS1

1.93e-04525225GO:0009410
GeneOntologyBiologicalProcesspyrimidine nucleobase metabolic process

DPYD CTPS1

2.48e-0422222GO:0006206
GeneOntologyBiologicalProcessregulation of DNA metabolic process

USP1 TTF1 NOX4 FANCB PARP4

2.69e-04564225GO:0051052
GeneOntologyBiologicalProcessamino acid metabolic process

BLMH NOX4 DPYD CTPS1

3.83e-04332224GO:0006520
GeneOntologyBiologicalProcessregulation of DNA biosynthetic process

USP1 NOX4 PARP4

4.11e-04138223GO:2000278
GeneOntologyBiologicalProcesspyrimidine ribonucleotide metabolic process

DPYD CTPS1

5.97e-0434222GO:0009218
GeneOntologyBiologicalProcessDNA metabolic process

USP1 TTF1 NOX4 FANCB PARP4 FAN1

7.38e-041081226GO:0006259
GeneOntologyBiologicalProcesssulfur amino acid metabolic process

BLMH NOX4

8.27e-0440222GO:0000096
GeneOntologyBiologicalProcessinterstrand cross-link repair

FANCB FAN1

9.11e-0442222GO:0036297
GeneOntologyBiologicalProcessnucleobase metabolic process

DPYD CTPS1

1.05e-0345222GO:0009112
DomainVIT

PARP4 VWA5B1

5.93e-0510222PS51468
DomainVIT

PARP4 VWA5B1

5.93e-0510222IPR013694
Domain-

PARP4 VWA5B1

3.40e-03742223.40.50.410
DomainVWFA

PARP4 VWA5B1

4.15e-0382222PS50234
DomainVWA

PARP4 VWA5B1

4.36e-0384222SM00327
DomainVWF_A

PARP4 VWA5B1

6.00e-0399222IPR002035
PathwayREACTOME_FANCONI_ANEMIA_PATHWAY

USP1 FANCB FAN1

2.16e-0539203MM15318
PathwayREACTOME_FANCONI_ANEMIA_PATHWAY

USP1 FANCB FAN1

2.16e-0539203M14990
PathwayPID_FANCONI_PATHWAY

USP1 FANCB FAN1

3.81e-0547203M1
PathwayWP_DNA_REPAIR_PATHWAYS_FULL_NETWORK

USP1 FANCB FAN1

6.17e-04120203M40049
Pubmed

Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway.

USP1 FANCB

3.25e-051323227986371
Pubmed

The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.

USP1 FANCB

4.37e-051523219536649
Pubmed

siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.

USP1 FANCB

1.35e-042623223435420
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

TBXAS1 NOX4 TMED9 PARP4 IPMK

1.64e-0481423523251661
Pubmed

CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.

USP1 PARP4 CTPS1

2.31e-0418223331067453
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

USP1 ZNF592 FSD2 PARP4

2.94e-0449723423414517
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

ZNF592 DPYD EIF2AK4 CTPS1

2.94e-0449723436774506
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

BLMH USP1 APLP2 EIF2AK4 FAN1

5.29e-04104923527880917
Pubmed

The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

USP1 ZNF592

6.53e-045723221555454
CytobandEnsembl 112 genes in cytogenetic band chr15q25

ZNF592 FSD2

2.91e-03160232chr15q25
ToppCell356C-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ZNF592 PARP4 IPMK

4.58e-05136233edfd453c9a650d69d05a5a3ab15f7df56349fa86
ToppCell356C-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ZNF592 PARP4 IPMK

4.58e-0513623303e4e2353c23ceffde35b2d0aadd15299e3db09f
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

USP1 CEP112 PARP4

7.84e-05163233130c84bca3f72ab7d1a4fee2990c3d01600318ed
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PARP4 VWA5B1 ASIC4

9.19e-051722338b396d1e9173da104d467e42286379fe07cee257
ToppCelldroplet-Kidney-nan-18m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOX4 APLP2 IPMK

1.12e-04184233e02859bbac36dbbd55d7ae8cb5e46b764d7c6381
ToppCell5'-Adult-LymphNode-Epithelial-goblet-BEST2+_Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF592 DPYD CTPS1

1.25e-04191233e5c41c3054ead03597c136eaccaf9822e6bb9d1a
ToppCell5'-Adult-LymphNode-Epithelial-goblet|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF592 DPYD CTPS1

1.25e-041912337e24175c7fabe5ea0b22b73173da4c3a666e5eb8
ToppCellCOPD-Myeloid|COPD / Disease state, Lineage and Cell class

TBXAS1 APLP2 DPYD

1.29e-04193233f58552e286aa27e592497ad78776f58f8ee09841
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TBXAS1 FANCB CTPS1

1.31e-04194233590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCellControl-Myeloid|Control / Disease state, Lineage and Cell class

TBXAS1 APLP2 DPYD

1.33e-0419523346ce2e403ca5d757e5ba17349b6c7ce5cde1f195
ToppCellPBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TBXAS1 APLP2 DPYD

1.33e-041952330110b976f98561ecd2e20ff6e7e3960a401bb7c2
ToppCellIPF-Myeloid|IPF / Disease state, Lineage and Cell class

TBXAS1 APLP2 DPYD

1.33e-04195233fdeb958aeaa00f3fc25c4e59efbbc6f4a572c9ce
ToppCellPBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TBXAS1 APLP2 DPYD

1.33e-04195233050fc59b328391d6e3ce23051764a842dcbb3144
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

USP1 FANCB CTPS1

1.33e-0419523356d8734d020b3da08a5aa9e67999706a9e023a99
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

USP1 FANCB CTPS1

1.33e-04195233b65463a804fed2d9a3be9e528ca8b9c98469bc86
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TBXAS1 APLP2 DPYD

1.35e-0419623328e9e191361966df3a9bd48450090577aa72a999
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TBXAS1 APLP2 DPYD

1.37e-041972332afc23f7394d9b40bdf06527c5e6b553e1b02dca
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TBXAS1 APLP2 DPYD

1.37e-0419723315bcfe6105c0b508811fb9bba0bc4312fea04f4c
ToppCell3'_v3-lymph-node_spleen-Myeloid_Monocytic-Classical_monocytes|lymph-node_spleen / Manually curated celltypes from each tissue

TBXAS1 APLP2 DPYD

1.39e-04198233187a04d498f0b355cb11c81172721698818082d6
ToppCellCOVID-19_Mild-Myeloid-Classical_Monocyte|COVID-19_Mild / Disease group, lineage and cell class

TBXAS1 APLP2 DPYD

1.39e-04198233e78d027a095473af555762a4d542a73f5bb2e166
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TBXAS1 APLP2 DPYD

1.39e-0419823374591eba5dbb2d77d416309326a26be969e4ad42
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TBXAS1 APLP2 DPYD

1.39e-041982333e1e79bb7b13540a06956b59c6a62984efea19ee
ToppCellPBMC-Mild-cDC_0|Mild / Compartment, Disease Groups and Clusters

TBXAS1 APLP2 DPYD

1.39e-04198233fb873b7636bb1c7b119dd5b23d7a20f518e6c6da
ToppCell3'_v3-lymph-node_spleen-Myeloid_Monocytic|lymph-node_spleen / Manually curated celltypes from each tissue

TBXAS1 APLP2 DPYD

1.39e-04198233065c8a9655d19f93dfdb453c78bbfe7d857caf3e
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TBXAS1 APLP2 DPYD

1.41e-0419923396dfbcf5261286f17d9718b04ebb7b288d229b52
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TBXAS1 APLP2 DPYD

1.41e-04199233b2dc3d0af6ecd3ab01779aaa1f061cb0f941cae8
ToppCellHealthy_donor-Classical_Monocyte|World / disease group, cell group and cell class (v2)

TBXAS1 APLP2 DPYD

1.41e-0419923345e9099a13becb1e235435ceaaffb92b82ce34ee
ToppCellSevere_COVID-19-Myeloid-MoAM3|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

TBXAS1 APLP2 DPYD

1.41e-0419923330523cf08815ca214877e33a2c52197ff8318557
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TBXAS1 APLP2 DPYD

1.41e-0419923387d513a521dd0359f4f79b01e9e97eacb0a3c6e2
ToppCellBAL-Severe-cDC_0|Severe / Compartment, Disease Groups and Clusters

TBXAS1 APLP2 DPYD

1.41e-04199233d39be8b173156bf87baddd3caed4b35597c53ea1
ToppCellPBMC-Control-cDC_0|Control / Compartment, Disease Groups and Clusters

TBXAS1 APLP2 DPYD

1.41e-04199233ebf03979ef56e978d72db475bb635b43b9cbe402
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TBXAS1 APLP2 DPYD

1.41e-04199233126a0ebd40e55c0dfb5e7c7dd8fdd733da6aa323
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TBXAS1 APLP2 DPYD

1.41e-041992330892957a49304ce4b6daa3657d76d8365ce0dd19
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

TBXAS1 APLP2 DPYD

1.41e-04199233105709b97c55826a852aed27658e3b4af1738c8a
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TBXAS1 APLP2 DPYD

1.41e-04199233961ad44199871be8e09d31904d383edc865ba262
ToppCellhealthy_donor-Myeloid-Monocytic-CD14+_Monocyte|healthy_donor / Disease condition, Lineage, Cell class and subclass

TBXAS1 APLP2 DPYD

1.44e-04200233e4f4ac674f3e085f52c6affeb6aeadaec7fffa73
ToppCellCOVID_vent-Myeloid-Monocytic-CD14+_Monocyte|COVID_vent / Disease condition, Lineage, Cell class and subclass

TBXAS1 APLP2 DPYD

1.44e-04200233e57452b73abb21cb3f645d45523ab93f6bef0243
ToppCellcontrol-HLA-DR-_S100A+_Monocyte|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TBXAS1 APLP2 DPYD

1.44e-042002339e3e13a68bc1110fa000ec2d80f4c654ddbce17e
ToppCellmild-HLA-DR+_CD83+_Monocyte|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TBXAS1 APLP2 DPYD

1.44e-042002338a480f487b52938d00b53bf4b18f067353d34419
ToppCellCOVID-19-COVID-19_Mild-Myeloid-CD14+_Monocyte|COVID-19_Mild / Disease, condition lineage and cell class

TBXAS1 APLP2 DPYD

1.44e-04200233f76d3647f8ab5f7be018b0697c911597198e03f5
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Gfra1-Inhibitory_Neuron.Gad1Gad2_Pvalb.Gfra1_(Interneuron,_Basket_1)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

PDE6B FSD2

4.06e-0458232f058992ac3c6c3bd56ff0d1e0c9de1d61e15b387
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Gfra1-Inhibitory_Neuron.Gad1Gad2_Pvalb.Gfra1_(Interneuron,_Basket_1)|Hippocampus / BrainAtlas - Mouse McCarroll V32

PDE6B FSD2

4.06e-0458232f9971c7e50844116d831be1c47fce1d213ac7228
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Gfra1|Hippocampus / BrainAtlas - Mouse McCarroll V32

PDE6B FSD2

4.06e-0458232a58f4ee94896c1f790335245163179f52705fae7
ComputationalNeighborhood of AIP

BLMH PDE6B TTF1

3.13e-0540173GCM_AIP
DiseaseFanconi anemia (implicated_via_orthology)

USP1 FAN1

1.62e-058232DOID:13636 (implicated_via_orthology)
Diseasegamma-glutamylglutamate measurement

EIF2AK4 IPMK

5.26e-0514232EFO_0021137
DiseaseColonic Neoplasms

NOX4 DPYD PARP4

2.20e-04152233C0009375
DiseaseMalignant tumor of colon

NOX4 DPYD PARP4

2.51e-04159233C0007102
DiseaseMalignant Head and Neck Neoplasm

FANCB DPYD

5.39e-0444232C0278996
DiseasePeripheral Nervous System Diseases

DPYD GJE1

8.11e-0454232C4721453
DiseaseAlzheimer's disease (implicated_via_orthology)

PITRM1 APLP2

9.04e-0457232DOID:10652 (implicated_via_orthology)
Diseasesocial interaction measurement

USP1 DPYD

2.43e-0394232EFO_0009592
Diseasecorneal topography

USP1 EIF2AK4

3.25e-03109232EFO_0004345
Diseasedocosahexaenoic acid measurement

USP1 IPMK

4.38e-03127232EFO_0007761
Diseasehypertension (implicated_via_orthology)

TBXAS1 NOX4

4.45e-03128232DOID:10763 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
PKHFRKDVDVVCVDM

TTF1

116

Q15361
EELAKKHCGEVMIFE

EIF2AK4

111

Q9P2K8
EFDHFVVDMKPFVLK

CEP112

16

Q8N8E3
EMELAKEEKCEFLPF

DPYD

376

Q12882
PEKCQFFHKERMEVC

APLP2

146

Q06481
KKMVNVEDVAECPHF

PDE6B

146

P35913
MPIEIVCKIKFAEED

ASIC4

1

Q96FT7
EKHPEKESEACMLVF

PARP4

846

Q9UKK3
EDVTHKFNKPCIMDV

IPMK

131

Q8NFU5
FTQHKFVKICMEEPR

NOX4

261

Q9NPH5
LLEHMKCEIIKEFPE

FANCB

676

Q8NB91
CMVPEHFEKTIFLIA

GJE1

161

A6NN92
EHVKPLFNMEDKICL

BLMH

256

Q13867
EEGEVTVCFKMKHDF

DCTN4

411

Q9UJW0
FKCDSLKEECIPEHM

FAN1

216

Q9Y2M0
EMCHEEKVDFIKDAV

FSD2

311

A1L4K1
PCFEEEEHFKVLVKM

PITRM1

691

Q5JRX3
VKEKISMFCHVEPEQ

CTPS1

226

P17812
EKKCFIEEIPDETMV

TMED9

46

Q9BVK6
VDVFKEKHMAPEFCS

TBXAS1

371

P24557
VPELHMFDHFCKKEP

ZNF592

191

Q92610
FDKMPEVITIHLKCF

USP1

521

O94782
EAFCEATHIPMEKLK

VWA5B1

1066

Q5TIE3