Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	MAN2A2 MAN2A1	1.51e-05	2	78	2	GO:0004572
Domain	ZnF_C2HC	FAM90A14 FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10	2.20e-09	55	75	7	SM00343
Domain	Znf_CCHC	FAM90A14 FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10	2.20e-09	55	75	7	IPR001878
Domain	ZINC_FINGER_C2H2_2	ZXDC ZNF536 VEZF1 ZNF425 ZSCAN5A FIZ1 PLAG1 ZNF217 TRMT1L ZNF565 ZNF319 ZNF865 ZNF786	1.15e-05	775	75	13	PS50157
Domain	ZINC_FINGER_C2H2_1	ZXDC ZNF536 VEZF1 ZNF425 ZSCAN5A FIZ1 PLAG1 ZNF217 TRMT1L ZNF565 ZNF319 ZNF865 ZNF786	1.18e-05	777	75	13	PS00028
Domain	Znf_C2H2-like	ZXDC ZNF536 VEZF1 ZNF425 ZSCAN5A FIZ1 PLAG1 ZNF217 TRMT1L ZNF565 ZNF319 ZNF865 ZNF786	1.52e-05	796	75	13	IPR015880
Domain	-	ZXDC ZNF536 VEZF1 ZNF425 ZSCAN5A FIZ1 PLAG1 ZNF217 ZNF565 ZNF319 ZNF865 ZNF786	1.55e-05	679	75	12	3.30.160.60
Domain	Znf_C2H2	ZXDC ZNF536 VEZF1 ZNF425 ZSCAN5A FIZ1 PLAG1 ZNF217 TRMT1L ZNF565 ZNF319 ZNF865 ZNF786	1.71e-05	805	75	13	IPR007087
Domain	ZnF_C2H2	ZXDC ZNF536 VEZF1 ZNF425 ZSCAN5A FIZ1 PLAG1 ZNF217 TRMT1L ZNF565 ZNF319 ZNF865 ZNF786	1.78e-05	808	75	13	SM00355
Domain	Znf_C2H2/integrase_DNA-bd	ZXDC ZNF536 VEZF1 ZNF425 ZSCAN5A FIZ1 PLAG1 ZNF217 ZNF565 ZNF319 ZNF865 ZNF786	1.92e-05	694	75	12	IPR013087
Domain	PLAC	ADAMTS10 ADAMTS18 ADAMTSL2	2.19e-05	14	75	3	PF08686
Domain	PLAC	ADAMTS10 ADAMTS18 ADAMTSL2	5.75e-05	19	75	3	PS50900
Domain	PLAC	ADAMTS10 ADAMTS18 ADAMTSL2	5.75e-05	19	75	3	IPR010909
Domain	ADAM_spacer1	ADAMTS10 ADAMTS18 ADAMTSL2	1.04e-04	23	75	3	IPR010294
Domain	ADAM_spacer1	ADAMTS10 ADAMTS18 ADAMTSL2	1.04e-04	23	75	3	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS10 ADAMTS18 ADAMTSL2	1.18e-04	24	75	3	IPR013273
Domain	-	MAN2A2 MAN2A1	1.58e-04	5	75	2	1.20.1270.50
Domain	-	MAN2A2 MAN2A1	1.58e-04	5	75	2	3.20.110.10
Domain	Glyco_hydro_38_C	MAN2A2 MAN2A1	1.58e-04	5	75	2	IPR011682
Domain	Alpha-mann_mid	MAN2A2 MAN2A1	1.58e-04	5	75	2	SM00872
Domain	Alpha-mann_mid	MAN2A2 MAN2A1	1.58e-04	5	75	2	PF09261
Domain	Glyco_hydro_38_N	MAN2A2 MAN2A1	1.58e-04	5	75	2	IPR000602
Domain	Glyco_hydro_38/57_N	MAN2A2 MAN2A1	1.58e-04	5	75	2	IPR027291
Domain	Glyco_hydro_38_cen	MAN2A2 MAN2A1	1.58e-04	5	75	2	IPR015341
Domain	Glyco_hydro_57/38_cen	MAN2A2 MAN2A1	1.58e-04	5	75	2	IPR028995
Domain	Glyco_hydro_38C	MAN2A2 MAN2A1	1.58e-04	5	75	2	PF07748
Domain	Glyco_hydro_38	MAN2A2 MAN2A1	1.58e-04	5	75	2	PF01074
Domain	RIH_assoc	RYR2 ITPR3	2.36e-04	6	75	2	PF08454
Domain	RIH_assoc-dom	RYR2 ITPR3	2.36e-04	6	75	2	IPR013662
Domain	RIH_dom	RYR2 ITPR3	2.36e-04	6	75	2	IPR000699
Domain	Ins145_P3_rcpt	RYR2 ITPR3	2.36e-04	6	75	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 ITPR3	2.36e-04	6	75	2	IPR015925
Domain	-	RYR2 ITPR3	2.36e-04	6	75	2	1.25.10.30
Domain	RYDR_ITPR	RYR2 ITPR3	2.36e-04	6	75	2	PF01365
Domain	Ins145_P3_rec	RYR2 ITPR3	2.36e-04	6	75	2	PF08709
Domain	Glyco_hydro/deAcase_b/a-brl	MAN2A2 MAN2A1	3.30e-04	7	75	2	IPR011330
Domain	eIF5C	EIF5 EIF4G3	3.30e-04	7	75	2	SM00515
Domain	W2	EIF5 EIF4G3	3.30e-04	7	75	2	PF02020
Domain	W2	EIF5 EIF4G3	3.30e-04	7	75	2	PS51363
Domain	W2_domain	EIF5 EIF4G3	3.30e-04	7	75	2	IPR003307
Domain	zf-C2H2	ZNF536 VEZF1 ZNF425 ZSCAN5A FIZ1 ZNF217 ZNF565 ZNF319 ZNF865 ZNF786	4.35e-04	693	75	10	PF00096
Domain	Peptidase_M12B_N	ADAMTS10 ADAM18 ADAMTS18	5.12e-04	39	75	3	IPR002870
Domain	Pep_M12B_propep	ADAMTS10 ADAM18 ADAMTS18	5.12e-04	39	75	3	PF01562
Domain	DISINTEGRIN_1	ADAMTS10 ADAM18 ADAMTS18	5.52e-04	40	75	3	PS00427
Domain	Reprolysin	ADAMTS10 ADAM18 ADAMTS18	5.52e-04	40	75	3	PF01421
Domain	ADAM_MEPRO	ADAMTS10 ADAM18 ADAMTS18	5.52e-04	40	75	3	PS50215
Domain	DISINTEGRIN_2	ADAMTS10 ADAM18 ADAMTS18	5.52e-04	40	75	3	PS50214
Domain	Peptidase_M12B	ADAMTS10 ADAM18 ADAMTS18	5.52e-04	40	75	3	IPR001590
Domain	EGF_1	EYS THBS4 ADAM18 ATRNL1 ITGB2 AGRN	5.60e-04	255	75	6	PS00022
Domain	Disintegrin_dom	ADAMTS10 ADAM18 ADAMTS18	5.94e-04	41	75	3	IPR001762
Domain	EGF-like_CS	EYS THBS4 ADAM18 ATRNL1 ITGB2 AGRN	6.32e-04	261	75	6	IPR013032
Domain	EGF_2	EYS THBS4 ADAM18 ATRNL1 ITGB2 AGRN	6.85e-04	265	75	6	PS01186
Domain	MIR	RYR2 ITPR3	7.01e-04	10	75	2	PS50919
Domain	MIR	RYR2 ITPR3	7.01e-04	10	75	2	PF02815
Domain	MIR	RYR2 ITPR3	7.01e-04	10	75	2	SM00472
Domain	MIR_motif	RYR2 ITPR3	7.01e-04	10	75	2	IPR016093
Domain	Laminin_G_1	EYS AGRN	8.55e-04	11	75	2	PF00054
Domain	-	MAN2A2 MAN2A1	1.40e-03	14	75	2	2.60.40.1180
Domain	Glyco_hydro_b	MAN2A2 MAN2A1	1.62e-03	15	75	2	IPR013780
Domain	MIF4-like	EIF5 EIF4G3	1.62e-03	15	75	2	IPR016021
Domain	-	EIF5 EIF4G3	1.62e-03	15	75	2	1.25.40.180
Domain	Laminin_G	EYS THBS4 AGRN	1.64e-03	58	75	3	IPR001791
Domain	EGF_extracell	ADAM18 ATRNL1 ITGB2	1.81e-03	60	75	3	IPR013111
Domain	EGF_2	ADAM18 ATRNL1 ITGB2	1.81e-03	60	75	3	PF07974
Domain	TSP_1	ADAMTS10 ADAMTS18 ADAMTSL2	2.08e-03	63	75	3	PF00090
Domain	Gal_mutarotase_SF_dom	MAN2A2 MAN2A1	2.08e-03	17	75	2	IPR011013
Domain	TSP1	ADAMTS10 ADAMTS18 ADAMTSL2	2.27e-03	65	75	3	SM00209
Domain	TSP1_rpt	ADAMTS10 ADAMTS18 ADAMTSL2	2.27e-03	65	75	3	IPR000884
Domain	TSP1	ADAMTS10 ADAMTS18 ADAMTSL2	2.27e-03	65	75	3	PS50092
Domain	EGF_3	EYS THBS4 ADAM18 ATRNL1 AGRN	2.55e-03	235	75	5	PS50026
Domain	EGF-like_dom	EYS THBS4 ADAM18 ATRNL1 AGRN	3.27e-03	249	75	5	IPR000742
Pathway	WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS	ADAMTS10 CREBBP ADAMTSL2 SMAD9	5.09e-05	59	49	4	M39886
Pubmed	Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A2P FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	1.54e-28	25	83	13	17684299
Pubmed	Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A2P FAM90A7 FAM90A9 FAM90A8 FAM90A16 FAM90A10	9.47e-24	23	83	11	18602769
Pubmed	Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A26 FAM90A23 FAM90A1 FAM90A7 FAM90A9 FAM90A8 FAM90A10	2.20e-13	164	83	11	22967998
Pubmed	Human T-cell leukemia virus type I tax repression of p73beta is mediated through competition for the C/H1 domain of CBP.	CREBBP TP73	5.63e-06	2	83	2	11279015
Pubmed	Regulatory mechanisms and pathophysiological significance of IP3 receptors and ryanodine receptors in drug dependence.	RYR2 ITPR3	5.63e-06	2	83	2	24285081
Pubmed	Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.	MAN2A2 MAN2A1	5.63e-06	2	83	2	8524845
Pubmed	Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells.	RYR2 ITPR3	5.63e-06	2	83	2	18586264
Pubmed	Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region.	RB1CC1 CREBBP	5.63e-06	2	83	2	36394358
Pubmed	TNF-α response of vascular endothelial and vascular smooth muscle cells involve differential utilization of ASK1 kinase and p73.	TP73 MAP3K5	5.63e-06	2	83	2	21738216
Pubmed	N-Glycan structure analysis using lectins and an alpha-mannosidase activity assay.	MAN2A2 MAN2A1	5.63e-06	2	83	2	17113875
Pubmed	Germ cell survival through carbohydrate-mediated interaction with Sertoli cells.	MAN2A2 MAN2A1	5.63e-06	2	83	2	11778047
Pubmed	Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice.	MAN2A2 MAN2A1	5.63e-06	2	83	2	16754854
Pubmed	ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.	VPS18 VPS16 RB1CC1	1.24e-05	19	83	3	33422265
Pubmed	Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts.	CD55 ITGB2	1.69e-05	3	83	2	11745332
Pubmed	The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis.	CREBBP TP73	1.69e-05	3	83	2	10648616
Pubmed	Role of the N-terminal activation domain of the coiled-coil coactivator in mediating transcriptional activation by beta-catenin.	CALCOCO1 CREBBP	3.37e-05	4	83	2	16931570
Pubmed	CBP-mediated post-translational N-glycosylation of BRCA2.	BRCA2 CREBBP	3.37e-05	4	83	2	19578754
Pubmed	The interaction of mammalian Class C Vps with nSec-1/Munc18-a and syntaxin 1A regulates pre-synaptic release.	VPS18 VPS16	3.37e-05	4	83	2	17027648
Pubmed	Molecular cloning and characterization of oppo 1: a haploid germ cell-specific complementary DNA encoding sperm tail protein.	AKAP4 ODF1	3.37e-05	4	83	2	12079992
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZXDC LIMK1 ZNF536 VEZF1 EIF5 PLAG1 ZNF217 CREBBP SMAD9	4.96e-05	709	83	9	22988430
Pubmed	Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families.	ADAMTS10 ADAMTSL2	5.60e-05	5	83	2	29758265
Pubmed	A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity.	CREBBP TP73	5.60e-05	5	83	2	25675294
Pubmed	Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33.	VPS18 VPS16	5.60e-05	5	83	2	11250079
Pubmed	Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase.	VPS18 VPS16	5.60e-05	5	83	2	16203730
Pubmed	Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.	VPS18 VPS16	8.39e-05	6	83	2	21802320
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR2 ITPR3	8.39e-05	6	83	2	23463619
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR2 ITPR3	8.39e-05	6	83	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR2 ITPR3	8.39e-05	6	83	2	25966694
Pubmed	CORVET, CHEVI and HOPS - multisubunit tethers of the endo-lysosomal system in health and disease.	VPS18 VPS16	8.39e-05	6	83	2	31092635
Pubmed	ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice.	RYR2 ITPR3	8.39e-05	6	83	2	16352659
Pubmed	Social isolation mediated anxiety like behavior is associated with enhanced expression and regulation of BDNF in the female mouse brain.	LIMK1 CREBBP	8.39e-05	6	83	2	26921097
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR2 ITPR3	8.39e-05	6	83	2	16844763
Pubmed	Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7.	VPS18 VPS16	8.39e-05	6	83	2	11382755
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	VPS18 KMT2B EIF5 LARS1 VPS16 RB1CC1 AP4B1	1.09e-04	454	83	7	33226137
Pubmed	RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking.	VPS18 VPS16	1.17e-04	7	83	2	25445562
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR2 ITPR3	1.17e-04	7	83	2	11860456
Pubmed	Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.	ZC3H14 ZNF536 CREBBP TP73	1.44e-04	110	83	4	37219487
Pubmed	SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.	VPS18 VPS16	1.56e-04	8	83	2	19109425
Pubmed	Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex.	VPS18 VPS16	1.56e-04	8	83	2	14623309
Pubmed	Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.	VPS18 VPS16	1.56e-04	8	83	2	25783203
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR2 ITPR3	1.56e-04	8	83	2	19033399
Pubmed	Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.	VPS18 VPS16	1.56e-04	8	83	2	23901104
Pubmed	Identification of the switch in early-to-late endosome transition.	VPS18 VPS16	1.56e-04	8	83	2	20434987
Pubmed	The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17.	VPS18 VPS16	1.56e-04	8	83	2	24554770
Pubmed	Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations.	VPS18 VPS16	2.00e-04	9	83	2	25266290
Pubmed	Modulating Wnt Signaling Rescues Palate Morphogenesis in Pax9 Mutant Mice.	DKK4 SMAD9	2.00e-04	9	83	2	28692808
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ZC3H14 EEF1G MAN2A1 KMT2B VEZF1 EIF5 CD55 MCM5 ZNF217 TRMT1L EIF4G3 AGRN	2.21e-04	1497	83	12	31527615
Pubmed	Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.	VPS18 VPS16	2.50e-04	10	83	2	26463206
Pubmed	Estrogen receptor (ER) beta or p53 attenuates ERalpha-mediated transcriptional activation on the BRCA2 promoter.	BRCA2 CREBBP	2.50e-04	10	83	2	18765668
Pubmed	HIV-1 gp120 N-linked glycosylation differs between plasma and leukocyte compartments.	MAN2A2 MAN2A1	2.50e-04	10	83	2	18215327
Pubmed	Glycosylation site-specific analysis of HIV envelope proteins (JR-FL and CON-S) reveals major differences in glycosylation site occupancy, glycoform profiles, and antigenic epitopes' accessibility.	MAN2A2 MAN2A1	2.50e-04	10	83	2	18330979
Pubmed	Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses.	MAN2A2 MAN2A1	2.50e-04	10	83	2	18314154
Pubmed	An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.	VPS18 VPS16	2.50e-04	10	83	2	18799622
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZXDC MAN2A2 KMT2B KMT5C MCM5 ZNF865 AGRN REXO1 MAP3K5 ITPR3	3.00e-04	1105	83	10	35748872
Pubmed	Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.	VPS18 VPS16	3.05e-04	11	83	2	18552835
Pubmed	Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways.	RB1CC1 MAP3K5	3.05e-04	11	83	2	17015619
Pubmed	New nomenclature for chromatin-modifying enzymes.	KMT2B KMT5C CREBBP	3.49e-04	57	83	3	18022353
Pubmed	Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.	KMT2B CREBBP	3.66e-04	12	83	2	17707229
Pubmed	Integrins.	ITGA10 ITGB2	3.66e-04	12	83	2	19693543
Pubmed	Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells.	VPS18 VPS16	3.66e-04	12	83	2	21411634
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS10 ADAMTS18	3.66e-04	12	83	2	25770910
Pubmed	Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex.	EEF1G LARS1	4.31e-04	13	83	2	11829477
Pubmed	UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.	VPS18 VPS16	4.31e-04	13	83	2	24550300
Pubmed	Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis.	CD55 ITGB2	5.03e-04	14	83	2	19299737
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZNF536 KMT2B BRCA2 FIZ1 ZNF217 RB1CC1	5.03e-04	418	83	6	34709266
Pubmed	Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.	MAN2A2 MAN2A1	5.79e-04	15	83	2	8892864
Pubmed	H-2 haplotypes, genes, and antigens: second listing. I. Non-H-2 loci on chromosome 17.	MAN2A1 ITPR3	7.48e-04	17	83	2	6816725
Pubmed	Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.	MAN2A2 MAN2A1	7.48e-04	17	83	2	2355006
Pubmed	Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton.	VPS18 VPS16	7.48e-04	17	83	2	14668490
Pubmed	Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.	CALCOCO1 CREBBP	7.48e-04	17	83	2	19183483
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS10 ADAMTS18 ADAMTSL2	7.82e-04	75	83	3	20637190
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	VPS18 EIF5 VPS16 RB1CC1 AP4B1 CREBBP	8.01e-04	457	83	6	32968282
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	ADAMTS10 SMAD9	8.40e-04	18	83	2	35503090
Pubmed	Genes, plasticity and mental retardation.	LIMK1 CREBBP	9.37e-04	19	83	2	18329113
Pubmed	Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.	MAN2A2 MAN2A1	1.04e-03	20	83	2	12560567
Pubmed	BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer	BRCA2 RB1CC1	1.15e-03	21	83	2	20301425
Pubmed	The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.	EEF1G EIF5 LARS1 MCM5 EIF4G3	1.18e-03	330	83	5	32529326
Pubmed	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	BRCA2 GAS2 CHST2 ITGB2	1.20e-03	193	83	4	20677014
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	EYS RNF19A PLAG1 ZNF217 CREBBP	1.22e-03	332	83	5	37433992
Pubmed	Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.	MAN2A2 MAN2A1	1.26e-03	22	83	2	8673525
Pubmed	Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation.	MAN2A2 MAN2A1	1.26e-03	22	83	2	9109416
Pubmed	Positional cloning of the mouse saccharin preference (Sac) locus.	AGRN TP73	1.26e-03	22	83	2	11555487
Pubmed	Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.	MAN2A2 MAN2A1	1.26e-03	22	83	2	11530211
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	ZC3H14 EEF1G KMT2B VEZF1 EIF5 LARS1 MCM5 ZNF217 CREBBP	1.26e-03	1103	83	9	34189442
Pubmed	Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function.	MAN2A2 MAN2A1	1.38e-03	23	83	2	1736542
Pubmed	Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.	MAN2A2 MAN2A1	1.38e-03	23	83	2	8093218
Pubmed	Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.	MAN2A2 MAN2A1	1.38e-03	23	83	2	3099781
Pubmed	Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.	MAN2A2 MAN2A1	1.38e-03	23	83	2	3264072
Pubmed	Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation.	RYR2 SMAD9	1.50e-03	24	83	2	34062094
Pubmed	Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.	MAN2A2 MAN2A1	1.63e-03	25	83	2	2283726
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	ZC3H14 LIMK1 LARS1 PLAG1 RB1CC1	1.69e-03	358	83	5	32460013
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	ZXDC EEF1G KMT2B ITPR3	1.75e-03	214	83	4	22199357
Pubmed	Transcriptional profiling of sequentially generated septal neuron fates.	FXYD6 TP73	1.76e-03	26	83	2	34851821
Pubmed	Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development.	CREBBP MAP3K5	1.76e-03	26	83	2	17177285
Pubmed	Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.	MAN2A2 MAN2A1	1.76e-03	26	83	2	8218172
Pubmed	Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.	ITGA10 ITGB2	1.90e-03	27	83	2	31541017
Pubmed	ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.	BRCA2 CREBBP	1.90e-03	27	83	2	17525332
Pubmed	ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development.	MAP3K5 SMAD9	2.04e-03	28	83	2	26173459
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	CEP104 ATRNL1 ADAMTSL2	2.06e-03	105	83	3	9628581
Pubmed	A genetic approach to Mammalian glycan function.	MAN2A2 MAN2A1	2.34e-03	30	83	2	12676797
Interaction	FAM90A26 interactions	FAM90A26 FAM90A1	1.19e-05	2	70	2	int:FAM90A26
Cytoband	8p23.1	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A2P FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	1.04e-16	154	83	12	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A2P FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	1.63e-14	234	83	12	chr8p23
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZXDC ZNF536 VEZF1 ZNF425 ZSCAN5A FIZ1 PLAG1 ZNF217 ZNF565 ZNF319 ZNF865 ZNF786	3.35e-07	718	49	12	28
GeneFamily	Mannosidases alpha class 2	MAN2A2 MAN2A1	7.16e-05	5	49	2	1194
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS10 ADAMTS18	1.19e-03	19	49	2	50
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2B KMT5C	3.82e-03	34	49	2	487
Coexpression	GSE19888_CTRL_VS_A3R_INHIBITOR_TREATED_MAST_CELL_DN	VEZF1 CALCOCO1 ZNF217 ZNF565 RB1CC1 CREBBP	1.63e-05	195	72	6	M7310
Coexpression	GSE2770_UNTREATED_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP	ZNF536 AKAP4 ATRNL1 ASAP3 PLAG1 ITGB2	1.88e-05	200	72	6	M6055
ToppCell	Control-PLT_4\|Control / Disease Group and Platelet Clusters	VEZF1 RNF19A EIF5 CD55 RB1CC1 RYR2	8.26e-07	198	72	6	387fd3037fd52e4d4c42de0588767e58af228b59
ToppCell	wk_20-22-Hematologic-Meg-ery-Definitive_erythroblast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MAN2A2 RNF19A CALCOCO1 EIF5 CD55	1.15e-05	182	72	5	0c77ef4556c1d1512ebe9077df858b28f9e38dd5
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS10 ZNF536 ATRNL1 FXYD6 RYR2	1.18e-05	183	72	5	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	Fibroblasts-CD55+_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	THBS4 FXYD6 CD55 CHST2 ITPR3	1.42e-05	190	72	5	b4088128f5acf53f43244c9af9fe44e033f1a57a
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	MAN2A1 GAS2 ADAMTS18 PLAG1 RB1CC1	1.49e-05	192	72	5	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ZNF536 BRCA2 ATRNL1 MCM5 ADAMTSL2	1.53e-05	193	72	5	bbdfda6665941cfa1965418bb91ef9ff43b1326f
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ZNF536 BRCA2 ATRNL1 MCM5 ADAMTSL2	1.57e-05	194	72	5	590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-dn_T\|Leuk-UTI / Disease, condition lineage and cell class	ZSCAN5A ITGA10 LBH PLAG1 MCM5	1.77e-05	199	72	5	aa4d8ce8994e5032a33d5cc68c482882147cdc3b
Disease	dystonia (is_implicated_in)	KMT2B VPS16	4.41e-04	14	66	2	DOID:543 (is_implicated_in)
Disease	nephroblastoma (is_implicated_in)	BRCA2 TP73	4.41e-04	14	66	2	DOID:2154 (is_implicated_in)
Disease	visceral:subcutaneous adipose tissue ratio	VPS18 ADAM18 TP73	5.26e-04	70	66	3	EFO_0004767
Disease	BREAST CANCER	BRCA2 RB1CC1	1.01e-03	21	66	2	114480
Disease	Heart valve disease	ITGB2 ADAMTSL2	1.55e-03	26	66	2	C0018824
Disease	Malignant tumor of breast	BRCA2 RB1CC1	1.67e-03	27	66	2	cv:C0006142
Disease	Breast neoplasm	BRCA2 RB1CC1	1.67e-03	27	66	2	cv:C1458155
Disease	Familial cancer of breast	BRCA2 RB1CC1	1.67e-03	27	66	2	cv:C0346153

Protein segments in the cluster

Peptide	Gene	Start	Entry
FTKDPCPLCDEAKEV	C5orf63	36	A6NC05
CQVRPNPEEKKCFDL	ASAP3	351	Q8TDY4
CPEGPKCQFAQKIRE	CPSF4L	156	A6NMK7
KLLNENPFKCEDPCE	AKAP4	636	Q5JQC9
CGFKNSQPLPCERKD	ADAM18	531	Q9Y3Q7
QENVFKKFDGPCDPC	AGRN	306	O00468
SKCQGAERCDPELPK	AP4B1	576	Q9Y6B7
DCPVCLPLKNASDKR	CREBBP	426	Q92793
CKCSFNQKPRAPGDE	FXYD6	61	Q9H0Q3
KQFDPFCPLKSVDCL	CC2D2B	1236	Q6DHV5
KPCCACPETKKARDA	COX17	21	Q14061
DEEDPRLKCKNCGAF	FAM90A10	36	A6NDY2
PEECKDVNKVAYCPL	ADAMTS10	1066	Q9H324
ACNTNFCPAPEKRED	ADAMTS18	1171	Q8TE60
DEEDPRLKCKNCGAF	FAM90A7	36	A6NKC0
AAGDLDNPPKKFRDC	ITPR3	41	Q14573
DNPPKKFRDCLFKVC	ITPR3	46	Q14573
SFCTQKPRKFDCELP	RB1CC1	561	Q8TDY2
DEEDPRLKCKNCGAF	FAM90A23	36	A8MXZ1
PFCELDVNKCKISPC	EYS	961	Q5T1H1
GPDPKICCQFDFKRL	MAN2A1	361	Q16706
KCNTDQAGRPKCPLD	MCM5	196	P33992
INHDCKPNCKFVPAD	KMT5C	181	Q86Y97
DEEDPRLKCKNCEAF	FAM90A1	36	Q86YD7
KKEQENNFDPACCPA	KIAA2026	536	Q5HYC2
PDPSDFDRCCKLKDR	LBH	46	Q53QV2
EFCKKKSCPNPGEIR	CD55	156	P08174
DEEDPRLKCKNCGAF	FAM90A22	36	A8MWA6
DEEDPRLKCKNCGAF	FAM90A14	36	P0C7W9
KKPPEESTCFERPCF	ADAMTSL2	841	Q86TH1
KFPIEDASNKLPCNC	KMT2B	2691	Q9UMN6
DEEDPRLKCKNCGAF	FAM90A17	36	P0DV74
ICKEFSLPPCVDEKD	ODF1	171	Q14990
DEEDPRLKCKNCGAF	FAM90A16	36	P0DV73
KEKERPPSCCAAAGA	IQSEC3	151	Q9UPP2
DEEDPRLKCKNCGAF	FAM90A19	36	P0DV76
DFGFDLPDCKARKQP	TP73	611	O15350
DEEDPRLKCKNCGAF	FAM90A8	36	A6NJQ4
CLPSNEDKEEFPLCA	FBXO17	81	Q96EF6
CPNKEKECQPPFAFR	ITGB2	191	P05107
KDCNPAKPEKLANRC	CEP104	831	O60308
AKPEKLANRCPLCHE	CEP104	836	O60308
GFIKKFVLCPECENP	EIF5	91	P55010
CAFPKEFANRCLSPE	BRCA2	2636	P51587
KFCLQPRDEKPFCAT	DKK4	51	Q9UBT3
KPPNCKAFRDEELCK	ATRNL1	611	Q5VV63
KPFKCPRCERDFNAP	FIZ1	226	Q96SL8
GPDPKICCQFDFKRL	MAN2A2	361	P49641
KLVPFSKDCGPDNEC	ITGA10	781	O75578
KCDLKPCPNTVDCFI	GJB7	156	Q6PEY0
CEQALAAEPKAKDPF	EEF1G	266	P26641
DEEDPRLKCKNCGAF	FAM90A20P	36	A6NIJ5
DEEDPRLKCKNCGAF	FAM90A5P	36	A8MXJ8
LLNFKDDKSECPCPE	RYR2	1976	Q92736
CPICKERFPAESDKD	CALCOCO1	656	Q9P1Z2
LPTNENDDDICKKPC	EIF4G3	326	O43432
NDDDICKKPCSVAPN	EIF4G3	331	O43432
DEEDPRLKCKNCGAF	FAM90A24P	36	P0C7X0
LKCFEPDPDKRACAN	MAP3K5	916	Q99683
EDPPCKCPNKFCVER	GAS2	211	O43903
QRCKKCPQPLFEDPE	RTP3	91	Q9BQQ7
APKKLCDPFGSCDAR	REXO1	271	Q8N1G1
GNRQACPLCPKEKFR	TRMT1L	116	Q7Z2T5
DKIREDCCPGKPLNV	LARS1	1046	Q9P2J5
DEEDPRLKCKNCGAF	FAM90A12P	36	A8MX19
DEEDPRLKCKNCGAF	FAM90A9	36	A6NNJ1
DEEDPRLKCKNCGAF	FAM90A13P	36	P0C7W8
DEEDPRLKCKNCGAF	FAM90A26	36	D6RGX4
FKLAPPLDCVEGKNC	PLA2G3	426	Q9NZ20
DEEDPRLKCKNCGAF	FAM90A15P	36	P0C7V4
ELKPLECCEFPFGSK	SMAD9	106	O15198
FKAQLFCCKAERPEP	BRS3	341	P32247
KKCPPQRLARFEEEC	CHST2	281	Q9Y4C5
GETKPRKNFPCQLCD	PLAG1	26	Q6DJT9
PDEELPCSARNCKKD	THBS4	471	P35443
CPDLESRCEKFLQKD	ZNF565	116	Q8N9K5
RPELRCPACLKAFKD	ZNF865	986	P0CJ78
RCPEPQCALAFAKKH	ZXDC	176	Q2QGD7
PFECPICNQRFKRKD	VEZF1	201	Q14119
DDIKPCPRCAAYIIK	RNF19A	296	Q9NV58
DKCATCDFPLLNRPF	VPS18	851	Q9P253
KEKLCEFNCNIRAPP	VPS16	251	Q9H269
DEEDPRLKCKNCRAL	FAM90A2P	36	Q658T7
KALPPFACDVCEKRF	ZSCAN5A	351	Q9BUG6
EDDARKNRKYPCPLC	ZNF536	121	O15090
ERPFHCPECDKNFRE	ZNF786	701	Q8N393
AREKPLKCPDCEKRF	ZNF319	481	Q9P2F9
EPPKEKNCKENEFSC	ZNF217	116	O75362
EQKPFPCAECGKRFT	ZNF425	466	Q6IV72
PCKAFPNCKFAEKCL	ZC3H14	621	Q6PJT7
CPLEVAAAPKLCKEF	TTC31	21	Q49AM3
DEEDPRLKCKNCGAF	FAM90A18	36	P0DV75
CCDLDPEKRPSFVKL	LIMK1	586	P53667