Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransporter activity

GABRD SLC37A1 TRPM4 ABCC1 SLC26A8 CLCN1 TMC2 PSEN1 ABCB10 SLC13A1 ABCB9 SLC16A1 SLC31A2 SLC45A3 SLC17A1 SLC22A2 OTOP2 SERINC3 SLC24A3 ATP11C ATP10B SLC13A3 CATSPER3 GRIK1 SERINC5 ATP1B2 ATP1B3 SLC2A2 SLC16A8 SLC22A12 ITPR1

5.81e-1512899231GO:0005215
GeneOntologyMolecularFunctiontransmembrane transporter activity

GABRD SLC37A1 TRPM4 ABCC1 SLC26A8 CLCN1 TMC2 PSEN1 ABCB10 SLC13A1 ABCB9 SLC16A1 SLC31A2 SLC45A3 SLC17A1 SLC22A2 OTOP2 SERINC3 SLC24A3 SLC13A3 CATSPER3 GRIK1 SERINC5 ATP1B2 ATP1B3 SLC2A2 SLC16A8 SLC22A12 ITPR1

3.27e-1411809229GO:0022857
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

GABRD SLC37A1 TRPM4 ABCC1 SLC26A8 CLCN1 TMC2 PSEN1 SLC13A1 SLC16A1 SLC31A2 SLC45A3 SLC17A1 OTOP2 SLC24A3 SLC13A3 CATSPER3 GRIK1 ATP1B2 ATP1B3 ITPR1

2.51e-117589221GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

GABRD TRPM4 SLC26A8 CLCN1 TMC2 PSEN1 SLC13A1 SLC16A1 SLC31A2 SLC45A3 SLC17A1 OTOP2 SLC24A3 SLC13A3 CATSPER3 GRIK1 ATP1B2 ATP1B3 ITPR1

2.89e-097939219GO:0015075
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC37A1 ABCC1 SLC26A8 ABCB10 SLC13A1 ABCB9 SLC16A1 SLC45A3 SLC17A1 SLC22A2 SLC24A3 SLC13A3 ATP1B2 ATP1B3 SLC16A8

4.59e-094779215GO:0022804
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

TRPM4 TMC2 PSEN1 SLC13A1 SLC16A1 SLC31A2 SLC45A3 SLC17A1 OTOP2 SLC24A3 SLC13A3 CATSPER3 GRIK1 ATP1B2 ATP1B3 ITPR1

2.54e-086279216GO:0022890
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

TRPM4 TMC2 PSEN1 SLC13A1 SLC16A1 SLC31A2 SLC45A3 SLC17A1 OTOP2 SLC24A3 SLC13A3 CATSPER3 GRIK1 ATP1B2 ATP1B3 ITPR1

5.62e-086649216GO:0008324
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC37A1 ABCC1 SLC26A8 SLC16A1 SLC22A2 SERINC3 SLC13A3 GRIK1 SERINC5 SLC2A2 SLC16A8

1.05e-072939211GO:0008514
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

TRPM4 TMC2 PSEN1 SLC13A1 SLC31A2 SLC17A1 SLC24A3 SLC13A3 CATSPER3 GRIK1 ATP1B2 ATP1B3 ITPR1

2.10e-074659213GO:0046873
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

ABCC1 SLC26A8 SLC16A1 SLC22A2 SERINC3 SLC13A3 GRIK1 SERINC5 SLC16A8

4.80e-07207929GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

ABCC1 SLC26A8 SLC16A1 SLC22A2 SERINC3 SLC13A3 GRIK1 SERINC5 SLC16A8

5.00e-07208929GO:0005342
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

TRPM4 SLC13A1 SLC17A1 SLC24A3 SLC13A3 GRIK1 ATP1B2 ATP1B3

1.24e-06171928GO:0015081
GeneOntologyMolecularFunctioncalcium channel activity

TRPM4 TMC2 PSEN1 SLC24A3 CATSPER3 GRIK1 ITPR1

2.21e-06129927GO:0005262
GeneOntologyMolecularFunctionsymporter activity

SLC13A1 SLC16A1 SLC45A3 SLC17A1 SLC24A3 SLC13A3 SLC16A8

6.03e-06150927GO:0015293
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

TRPM4 TMC2 PSEN1 SLC24A3 CATSPER3 GRIK1 ITPR1

6.30e-06151927GO:0015085
GeneOntologyMolecularFunctionmonoatomic ion channel activity

GABRD TRPM4 SLC26A8 CLCN1 TMC2 PSEN1 OTOP2 SLC24A3 CATSPER3 GRIK1 ITPR1

8.46e-064599211GO:0005216
GeneOntologyMolecularFunctionsulfur compound transmembrane transporter activity

ABCC1 SLC26A8 SLC13A1 SLC22A2 SLC13A3

9.03e-0661925GO:1901682
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC37A1 SLC26A8 SLC13A1 SLC16A1 SLC45A3 SLC17A1 SLC24A3 SLC13A3 SLC16A8

9.06e-06296929GO:0015291
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC26A8 SLC13A1 SLC16A1 SLC45A3 SLC17A1 SLC24A3 SLC13A3 ATP1B2 ATP1B3

1.04e-05301929GO:0022853
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

GABRD SLC37A1 ABCC1 SLC26A8 CLCN1 SLC13A1 SLC17A1

1.42e-05171927GO:0015103
GeneOntologyMolecularFunctionL-amino acid transmembrane transporter activity

SLC22A2 SERINC3 SLC13A3 GRIK1 SERINC5

1.91e-0571925GO:0015179
GeneOntologyMolecularFunctionATP-dependent activity

ABCC1 MDN1 ABCB10 ABCB9 SMARCAL1 ATP11C ATP10B ATP1B2 ATP1B3 DICER1 ACSS3 HELB

2.47e-056149212GO:0140657
GeneOntologyMolecularFunctionchannel activity

GABRD TRPM4 SLC26A8 CLCN1 TMC2 PSEN1 OTOP2 SLC24A3 CATSPER3 GRIK1 ITPR1

2.94e-055259211GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

GABRD TRPM4 SLC26A8 CLCN1 TMC2 PSEN1 OTOP2 SLC24A3 CATSPER3 GRIK1 ITPR1

2.99e-055269211GO:0022803
GeneOntologyMolecularFunctionneurexin family protein binding

NLGN3 NLGN4X NLGN4Y

5.07e-0516923GO:0042043
GeneOntologyMolecularFunctionoligopeptide transmembrane transporter activity

ABCC1 ABCB9 SLC13A3

5.07e-0516923GO:0035673
GeneOntologyMolecularFunctiontachykinin receptor activity

TACR2 TACR3

6.28e-053922GO:0004995
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC22A2 SERINC3 SLC13A3 GRIK1 SERINC5

1.25e-04105925GO:0015171
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCC1 ABCB10 ABCB9 ATP1B2 ATP1B3

1.49e-04109925GO:0042626
GeneOntologyMolecularFunctionmonoatomic cation channel activity

TRPM4 TMC2 PSEN1 OTOP2 SLC24A3 CATSPER3 GRIK1 ITPR1

1.86e-04343928GO:0005261
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC13A1 SLC16A1 SLC45A3 SLC17A1 SLC13A3

2.25e-04119925GO:0015294
GeneOntologyMolecularFunctionsuccinate transmembrane transporter activity

SLC16A1 SLC13A3

3.11e-046922GO:0015141
GeneOntologyMolecularFunctionlactate transmembrane transporter activity

SLC16A1 SLC16A8

3.11e-046922GO:0015129
GeneOntologyMolecularFunctiondicarboxylic acid transmembrane transporter activity

SLC26A8 SLC16A1 SLC13A3

3.87e-0431923GO:0005310
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TRPM4 GRIK1 ITPR1

3.87e-0431923GO:0099604
GeneOntologyMolecularFunctionglutathione transmembrane transporter activity

ABCC1 SLC13A3

4.34e-047922GO:0034634
GeneOntologyMolecularFunctionaspartic endopeptidase activity, intramembrane cleaving

PSEN1 PSEN2

5.77e-048922GO:0042500
GeneOntologyMolecularFunctionvitamin transmembrane transporter activity

ABCC1 SLC22A2 SLC2A2

6.05e-0436923GO:0090482
GeneOntologyMolecularFunctiontripeptide transmembrane transporter activity

ABCC1 SLC13A3

7.40e-049922GO:0042937
GeneOntologyMolecularFunctionL-serine transmembrane transporter activity

SERINC3 SERINC5

7.40e-049922GO:0015194
GeneOntologyMolecularFunctiongated channel activity

GABRD TRPM4 CLCN1 TMC2 CATSPER3 GRIK1 ITPR1

8.93e-04334927GO:0022836
GeneOntologyMolecularFunctionscaffold protein binding

NLGN3 NLGN4X NLGN4Y GRIK1

9.01e-0493924GO:0097110
GeneOntologyMolecularFunctionP-type sodium transporter activity

ATP1B2 ATP1B3

9.22e-0410922GO:0008554
GeneOntologyMolecularFunctionP-type sodium:potassium-exchanging transporter activity

ATP1B2 ATP1B3

9.22e-0410922GO:0005391
GeneOntologyMolecularFunctionamide transmembrane transporter activity

ABCC1 ABCB9 SLC13A3

9.54e-0442923GO:0042887
GeneOntologyMolecularFunctionP-type potassium transmembrane transporter activity

ATP1B2 ATP1B3

1.12e-0311922GO:0008556
GeneOntologyMolecularFunctionsecondary active sulfate transmembrane transporter activity

SLC26A8 SLC13A1

1.12e-0311922GO:0008271
GeneOntologyMolecularFunctionsiRNA binding

AGO2 DICER1

1.34e-0312922GO:0035197
GeneOntologyMolecularFunctionprimary active transmembrane transporter activity

ABCC1 ABCB10 ABCB9 ATP1B2 ATP1B3

1.40e-03178925GO:0015399
GeneOntologyMolecularFunctionmiRNA binding

AGO2 AGO4 DICER1

1.41e-0348923GO:0035198
GeneOntologyMolecularFunctionABC-type transporter activity

ABCC1 ABCB10 ABCB9

1.50e-0349923GO:0140359
GeneOntologyMolecularFunctionATPase binding

PSEN1 ATP1B2 ATP1B3 AR

1.57e-03108924GO:0051117
GeneOntologyMolecularFunctionglycerophospholipid flippase activity

ATP11C ATP10B

1.84e-0314922GO:0140333
GeneOntologyMolecularFunctionC4-dicarboxylate transmembrane transporter activity

SLC16A1 SLC13A3

2.12e-0315922GO:0015556
GeneOntologyMolecularFunctionefflux transmembrane transporter activity

ABCC1 SLC22A2

2.42e-0316922GO:0015562
GeneOntologyMolecularFunctionsulfate transmembrane transporter activity

SLC26A8 SLC13A1

2.42e-0316922GO:0015116
GeneOntologyMolecularFunctionchloride ion binding

NLGN4X NLGN4Y

2.42e-0316922GO:0031404
GeneOntologyMolecularFunctionflippase activity

ATP11C ATP10B

2.73e-0317922GO:0140327
GeneOntologyMolecularFunctionregulatory RNA binding

AGO2 AGO4 DICER1

2.94e-0362923GO:0061980
GeneOntologyMolecularFunctionbasal RNA polymerase II transcription machinery binding

AGO2 TAF1 AR

3.51e-0366923GO:0001099
GeneOntologyMolecularFunctionbasal transcription machinery binding

AGO2 TAF1 AR

3.51e-0366923GO:0001098
GeneOntologyMolecularFunctionacidic amino acid transmembrane transporter activity

SLC13A3 GRIK1

3.78e-0320922GO:0015172
GeneOntologyMolecularFunctionsphingolipid transporter activity

ABCC1 ATP10B

3.78e-0320922GO:0046624
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCC1 MDN1 ABCB10 ABCB9 ATP11C ATP10B HELB

4.27e-03441927GO:0016887
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

GABRD GRIK1 CHRM3

5.03e-0375923GO:0098960
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

GABRD SLC26A8 CLCN1 SLC13A1

5.25e-03151924GO:0008509
GeneOntologyMolecularFunctionphosphate transmembrane transporter activity

SLC37A1 SLC17A1

5.43e-0324922GO:0005315
GeneOntologyMolecularFunctiondouble-stranded RNA binding

AGO2 AGO4 DICER1

5.61e-0378923GO:0003725
GeneOntologyMolecularFunctionRNA endonuclease activity

AGO2 AGO4 DICER1

5.81e-0379923GO:0004521
GeneOntologyMolecularFunctionsolute:proton symporter activity

SLC16A1 SLC45A3

5.88e-0325922GO:0015295
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC13A1 SLC17A1 SLC13A3

6.23e-0381923GO:0015370
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

SLC22A2 SERINC3 SERINC5

6.67e-0383923GO:0015101
GeneOntologyMolecularFunctionRNA polymerase II general transcription initiation factor binding

TAF1 AR

6.84e-0327922GO:0001091
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ATP11C ATP10B

7.34e-0328922GO:0140326
GeneOntologyMolecularFunctionchloride channel activity

GABRD SLC26A8 CLCN1

7.35e-0386923GO:0005254
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

SLC24A3 GRIK1 ATP1B2 ATP1B3

7.45e-03167924GO:0015079
GeneOntologyMolecularFunctionsugar transmembrane transporter activity

SLC45A3 SLC2A2

7.86e-0329922GO:0051119
GeneOntologyMolecularFunctionmonocarboxylic acid transmembrane transporter activity

ABCC1 SLC16A1 SLC16A8

8.33e-0390923GO:0008028
GeneOntologyMolecularFunctionsolute:inorganic anion antiporter activity

SLC37A1 SLC26A8

9.52e-0332922GO:0005452
GeneOntologyMolecularFunctionATPase activator activity

ATP1B2 ATP1B3

9.52e-0332922GO:0001671
GeneOntologyBiologicalProcessmonoatomic ion transport

GABRD TRPM4 ABCC1 NLGN3 SLC26A8 CLCN1 TMC2 PSEN1 PSEN2 SLC13A1 GPER1 SLC16A1 SLC31A2 SLC17A1 SLC22A2 OTOP2 SRL SLC24A3 ATP11C TACR2 SLC13A3 CATSPER3 GRIK1 ATP1B2 ATP1B3 SLC22A12 ITPR1

2.07e-1113749127GO:0006811
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

GABRD TRPM4 ABCC1 NLGN3 SLC26A8 CLCN1 TMC2 PSEN1 PSEN2 SLC13A1 GPER1 SLC16A1 SLC31A2 SLC17A1 OTOP2 SLC24A3 ATP11C SLC13A3 CATSPER3 GRIK1 ATP1B2 ATP1B3 ITPR1

3.54e-1011159123GO:0034220
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

GABRD SLC37A1 TRPM4 SLC26A8 CLCN1 TMC2 PSEN1 PSEN2 SLC13A1 GPER1 SLC16A1 SLC31A2 SLC17A1 OTOP2 SLC24A3 SLC13A3 CATSPER3 GRIK1 ATP1B2 ATP1B3 ITPR1

2.38e-0910179121GO:0098660
GeneOntologyBiologicalProcessamide transport

TRPM4 ABCC1 ABCB9 GPER1 SLC16A1 RAPGEF4 TACR2 SLC13A3 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

3.91e-084209113GO:0042886
GeneOntologyBiologicalProcessorganic anion transport

SLC37A1 ABCC1 SLC26A8 PSEN1 SLC16A1 SLC17A1 SLC22A2 SERINC3 SLC13A3 GRIK1 SERINC5 SLC2A2 SLC16A8 SLC22A12

5.64e-085159114GO:0015711
GeneOntologyBiologicalProcessmale courtship behavior

NLGN4X NLGN4Y AR

3.31e-074913GO:0008049
GeneOntologyBiologicalProcessvascular process in circulatory system

TRPM4 ABCC1 GPER1 SLC16A1 SLC22A2 SLC24A3 TACR2 SLC13A3 HMGCR ATP1B2 CHRM3

3.41e-073449111GO:0003018
GeneOntologyBiologicalProcesspeptide transport

TRPM4 ABCB9 GPER1 SLC16A1 RAPGEF4 TACR2 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

4.66e-073559111GO:0015833
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

TRPM4 TMC2 PSEN1 PSEN2 SLC13A1 GPER1 SLC16A1 SLC31A2 SLC17A1 OTOP2 SLC24A3 SLC13A3 CATSPER3 GRIK1 ATP1B2 ATP1B3 ITPR1

4.99e-079229117GO:0098662
GeneOntologyBiologicalProcessmonoatomic cation transport

TRPM4 TMC2 PSEN1 PSEN2 SLC13A1 GPER1 SLC16A1 SLC31A2 SLC17A1 SLC22A2 OTOP2 SRL SLC24A3 SLC13A3 CATSPER3 GRIK1 ATP1B2 ATP1B3 ITPR1

5.61e-0711579119GO:0006812
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

TRPM4 TMC2 PSEN1 PSEN2 SLC13A1 GPER1 SLC16A1 SLC31A2 SLC17A1 OTOP2 SLC24A3 SLC13A3 CATSPER3 GRIK1 ATP1B2 ATP1B3 ITPR1

6.72e-079429117GO:0098655
GeneOntologyBiologicalProcessregulation of insulin secretion

TRPM4 GPER1 SLC16A1 RAPGEF4 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

8.38e-07231919GO:0050796
GeneOntologyBiologicalProcesspeptide hormone secretion

TRPM4 GPER1 SLC16A1 RAPGEF4 TACR2 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

2.18e-063349110GO:0030072
GeneOntologyBiologicalProcesstransport across blood-brain barrier

ABCC1 SLC16A1 SLC22A2 SLC24A3 SLC13A3 ATP1B2

2.37e-0687916GO:0150104
GeneOntologyBiologicalProcessvascular transport

ABCC1 SLC16A1 SLC22A2 SLC24A3 SLC13A3 ATP1B2

2.53e-0688916GO:0010232
GeneOntologyBiologicalProcesspeptide secretion

TRPM4 GPER1 SLC16A1 RAPGEF4 TACR2 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

2.76e-063439110GO:0002790
GeneOntologyBiologicalProcesscourtship behavior

NLGN4X NLGN4Y AR

2.87e-067913GO:0007619
GeneOntologyBiologicalProcessinsulin secretion

TRPM4 GPER1 SLC16A1 RAPGEF4 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

3.42e-06274919GO:0030073
GeneOntologyBiologicalProcesssodium ion transport

TRPM4 SLC13A1 SLC17A1 SLC24A3 SLC13A3 CATSPER3 GRIK1 ATP1B2 ATP1B3

3.53e-06275919GO:0006814
GeneOntologyBiologicalProcessregulation of peptide hormone secretion

TRPM4 GPER1 SLC16A1 RAPGEF4 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

3.74e-06277919GO:0090276
GeneOntologyBiologicalProcessregulation of hormone secretion

TRPM4 GPER1 SLC16A1 RAPGEF4 TACR2 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

3.75e-063559110GO:0046883
GeneOntologyBiologicalProcesscirculatory system process

TRPM4 ABCC1 PSEN2 GPER1 SLC16A1 SLC22A2 SLC24A3 TACR2 SLC13A3 HMGCR TACR3 ATP1B2 CHRM3 AR

3.84e-067339114GO:0003013
GeneOntologyBiologicalProcesssodium ion transmembrane transport

TRPM4 SLC13A1 SLC17A1 SLC24A3 SLC13A3 GRIK1 ATP1B2 ATP1B3

3.88e-06208918GO:0035725
GeneOntologyBiologicalProcessregulation of peptide transport

TRPM4 GPER1 SLC16A1 RAPGEF4 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

4.32e-06282919GO:0090087
GeneOntologyBiologicalProcessregulation of peptide secretion

TRPM4 GPER1 SLC16A1 RAPGEF4 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

4.32e-06282919GO:0002791
GeneOntologyBiologicalProcesspositive regulation of uterine smooth muscle contraction

GPER1 TACR2 TACR3

6.85e-069913GO:0070474
GeneOntologyBiologicalProcessmetal ion transport

TRPM4 TMC2 PSEN1 PSEN2 SLC13A1 GPER1 SLC31A2 SLC17A1 SRL SLC24A3 SLC13A3 CATSPER3 GRIK1 ATP1B2 ATP1B3 ITPR1

7.01e-0610009116GO:0030001
GeneOntologyBiologicalProcesspresynaptic membrane assembly

NLGN3 NLGN4X NLGN4Y

9.75e-0610913GO:0097105
GeneOntologyBiologicalProcessRISC complex assembly

AGO2 AGO4 DICER1

9.75e-0610913GO:0070922
GeneOntologyBiologicalProcesssulfur compound transport

ABCC1 SLC26A8 SLC13A1 SLC22A2 SLC13A3

1.00e-0565915GO:0072348
GeneOntologyBiologicalProcesscarboxylic acid transport

ABCC1 SLC26A8 PSEN1 SLC16A1 SLC22A2 SERINC3 SLC13A3 GRIK1 SERINC5 SLC16A8

1.32e-054109110GO:0046942
GeneOntologyBiologicalProcesspostsynaptic membrane assembly

NLGN3 NLGN4X NLGN4Y

1.34e-0511913GO:0097104
GeneOntologyBiologicalProcessorganic acid transport

ABCC1 SLC26A8 PSEN1 SLC16A1 SLC22A2 SERINC3 SLC13A3 GRIK1 SERINC5 SLC16A8

1.38e-054129110GO:0015849
GeneOntologyBiologicalProcesspositive regulation of insulin secretion

TRPM4 GPER1 RAPGEF4 CHRM3 SLC2A2 ITPR1

1.52e-05120916GO:0032024
GeneOntologyBiologicalProcesshormone secretion

TRPM4 GPER1 SLC16A1 RAPGEF4 TACR2 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

1.63e-054209110GO:0046879
GeneOntologyBiologicalProcessregulation of uterine smooth muscle contraction

GPER1 TACR2 TACR3

1.78e-0512913GO:0070472
GeneOntologyBiologicalProcesspositive regulation of smooth muscle contraction

GPER1 TACR2 TACR3 CHRM3

1.87e-0536914GO:0045987
GeneOntologyBiologicalProcesspositive regulation of serine C-palmitoyltransferase activity

SERINC1 SERINC5

1.93e-052912GO:1904222
GeneOntologyBiologicalProcessregulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity

SERINC1 SERINC5

1.93e-052912GO:1904217
GeneOntologyBiologicalProcessregulation of system process

TRPM4 NLGN3 NLGN4X GPER1 RAPGEF4 SRL TACR2 GRIK1 HMGCR TACR3 ATP1B2 CHRM3 DICER1

1.96e-057349113GO:0044057
GeneOntologyBiologicalProcesshormone transport

TRPM4 GPER1 SLC16A1 RAPGEF4 TACR2 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

2.07e-054329110GO:0009914
GeneOntologyBiologicalProcessuterine smooth muscle contraction

GPER1 TACR2 TACR3

2.30e-0513913GO:0070471
GeneOntologyBiologicalProcesspresynaptic membrane organization

NLGN3 NLGN4X NLGN4Y

2.30e-0513913GO:0097090
GeneOntologyBiologicalProcessregulation of protein secretion

TRPM4 GPER1 SLC16A1 RAPGEF4 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

2.43e-05350919GO:0050708
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

GABRD SLC37A1 SLC26A8 CLCN1 SLC13A1 SLC17A1

2.85e-05134916GO:0098661
GeneOntologyBiologicalProcessbehavior

TRPM4 NLGN3 NLGN4X PSEN1 PSEN2 SLC16A1 NLGN4Y TACR2 GRIK1 HMGCR TACR3 ATP1B2 UNC79 AR

3.44e-058919114GO:0007610
GeneOntologyBiologicalProcessregulation of membrane potential

GABRD TRPM4 NLGN3 CLCN1 NLGN4X PSEN1 GPER1 RAPGEF4 GRIK1 ATP1B2 ATP1B3

3.50e-055599111GO:0042391
GeneOntologyBiologicalProcessregulation of protein transport

TRPM4 PSEN1 GPER1 UBR5 SLC16A1 RAPGEF4 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

3.56e-055609111GO:0051223
GeneOntologyBiologicalProcessmale mating behavior

NLGN4X NLGN4Y AR

3.64e-0515913GO:0060179
GeneOntologyBiologicalProcessregulation of establishment of protein localization

TRPM4 PSEN1 GPER1 UBR5 SLC16A1 RAPGEF4 PARL HMGCR FAM3D CHRM3 SLC2A2 ITPR1

4.00e-056749112GO:0070201
GeneOntologyBiologicalProcessexport from cell

TRPM4 ABCC1 PSEN1 GPER1 SLC16A1 SLC22A2 RAPGEF4 TACR2 HMGCR ATP1B2 ATP1B3 FAM3D CHRM3 SLC2A2 EXOC8 ITPR1

4.04e-0511539116GO:0140352
GeneOntologyBiologicalProcessneuron cell-cell adhesion

NLGN3 NLGN4X NLGN4Y

4.46e-0516913GO:0007158
GeneOntologyBiologicalProcessprotein secretion

TRPM4 GPER1 SLC16A1 RAPGEF4 TACR2 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

5.06e-054809110GO:0009306
GeneOntologyBiologicalProcessestablishment of protein localization to extracellular region

TRPM4 GPER1 SLC16A1 RAPGEF4 TACR2 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

5.33e-054839110GO:0035592
GeneOntologyBiologicalProcessoligopeptide transmembrane transport

ABCC1 ABCB9 SLC13A3

5.40e-0517913GO:0035672
GeneOntologyBiologicalProcesspre-miRNA processing

AGO2 AGO4 DICER1

5.40e-0517913GO:0031054
GeneOntologyBiologicalProcessterritorial aggressive behavior

NLGN4X NLGN4Y

5.76e-053912GO:0002124
GeneOntologyBiologicalProcessprotein localization to extracellular region

TRPM4 GPER1 SLC16A1 RAPGEF4 TACR2 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

6.01e-054909110GO:0071692
GeneOntologyBiologicalProcesspositive regulation of peptide hormone secretion

TRPM4 GPER1 RAPGEF4 CHRM3 SLC2A2 ITPR1

6.91e-05157916GO:0090277
GeneOntologyBiologicalProcesspositive regulation of peptide secretion

TRPM4 GPER1 RAPGEF4 CHRM3 SLC2A2 ITPR1

7.94e-05161916GO:0002793
GeneOntologyBiologicalProcesspositive regulation of protein transport

TRPM4 PSEN1 GPER1 UBR5 RAPGEF4 CHRM3 SLC2A2 ITPR1

8.37e-05319918GO:0051222
GeneOntologyBiologicalProcesscarboxylic acid transmembrane transport

ABCC1 PSEN1 SLC16A1 SLC22A2 SLC13A3 SLC16A8

8.51e-05163916GO:1905039
GeneOntologyBiologicalProcessorganic acid transmembrane transport

ABCC1 PSEN1 SLC16A1 SLC22A2 SLC13A3 SLC16A8

9.72e-05167916GO:1903825
GeneOntologyBiologicalProcessphospholipid translocation

ABCC1 SLC66A2 ATP11C ATP10B

1.02e-0455914GO:0045332
GeneOntologyBiologicalProcessprotein catabolic process at postsynapse

PSEN1 PSEN2

1.15e-044912GO:0140249
GeneOntologyBiologicalProcessregulation of serine C-palmitoyltransferase activity

SERINC1 SERINC5

1.15e-044912GO:1904220
GeneOntologyBiologicalProcesssiRNA-mediated post-transcriptional gene silencing

AGO2 AGO4

1.15e-044912GO:0140766
GeneOntologyBiologicalProcesssiRNA-mediated gene silencing by mRNA destabilization

AGO2 AGO4

1.15e-044912GO:0090625
GeneOntologyBiologicalProcesspositive regulation of sodium ion export across plasma membrane

ATP1B2 ATP1B3

1.15e-044912GO:1903278
GeneOntologyBiologicalProcesspositive regulation of muscle contraction

GPER1 TACR2 TACR3 CHRM3

1.34e-0459914GO:0045933
GeneOntologyBiologicalProcessoligopeptide transport

ABCC1 ABCB9 SLC13A3

1.38e-0423913GO:0006857
GeneOntologyBiologicalProcesssignal release

TRPM4 PSEN1 GPER1 SLC16A1 RAPGEF4 TACR2 HMGCR FAM3D CHRM3 SLC2A2 ITPR1

1.40e-046539111GO:0023061
GeneOntologyBiologicalProcesslipid translocation

ABCC1 SLC66A2 ATP11C ATP10B

1.43e-0460914GO:0034204
GeneOntologyBiologicalProcessinorganic anion transport

GABRD SLC37A1 SLC26A8 CLCN1 SLC13A1 SLC17A1

1.47e-04180916GO:0015698
GeneOntologyBiologicalProcessvocalization behavior

NLGN3 NLGN4X NLGN4Y

1.57e-0424913GO:0071625
GeneOntologyBiologicalProcessmonoatomic anion transport

GABRD ABCC1 SLC26A8 CLCN1 SLC13A1 SLC17A1

1.60e-04183916GO:0006820
GeneOntologyBiologicalProcessregulation of sodium ion export across plasma membrane

ATP1B2 ATP1B3

1.91e-045912GO:1903276
GeneOntologyBiologicalProcessregulation of membrane lipid distribution

ABCC1 SLC66A2 ATP11C ATP10B

1.95e-0465914GO:0097035
GeneOntologyBiologicalProcesspositive regulation of protein secretion

TRPM4 GPER1 RAPGEF4 CHRM3 SLC2A2 ITPR1

2.20e-04194916GO:0050714
GeneOntologyBiologicalProcessamino acid transport

PSEN1 SLC22A2 SERINC3 SLC13A3 GRIK1 SERINC5

2.26e-04195916GO:0006865
GeneOntologyBiologicalProcesslearning or memory

TRPM4 NLGN3 NLGN4X PSEN1 PSEN2 NLGN4Y TACR2 HMGCR

2.44e-04373918GO:0007611
GeneOntologyBiologicalProcessendoplasmic reticulum calcium ion homeostasis

PSEN1 PSEN2 ITPR1

2.79e-0429913GO:0032469
GeneOntologyBiologicalProcessregulation of protein localization

TRPM4 NLGN3 PSEN1 GPER1 UBR5 SLC16A1 RAPGEF4 PARL HMGCR FAM3D CHRM3 AR SLC2A2 ITPR1

2.81e-0410879114GO:0032880
GeneOntologyBiologicalProcessprotein catabolic process at synapse

PSEN1 PSEN2

2.85e-046912GO:0140246
GeneOntologyBiologicalProcessxenobiotic transport across blood-brain barrier

ABCC1 SLC22A2

2.85e-046912GO:1990962
GeneOntologyBiologicalProcesssuccinate transmembrane transport

SLC16A1 SLC13A3

2.85e-046912GO:0071422
GeneOntologyBiologicalProcesssuccinate transport

SLC16A1 SLC13A3

2.85e-046912GO:0015744
GeneOntologyBiologicalProcessL-serine biosynthetic process

SERINC3 SERINC5

2.85e-046912GO:0006564
GeneOntologyBiologicalProcesspositive regulation of hormone secretion

TRPM4 GPER1 RAPGEF4 CHRM3 SLC2A2 ITPR1

2.96e-04205916GO:0046887
GeneOntologyBiologicalProcessmembrane biogenesis

NLGN3 NLGN4X SERINC1 NLGN4Y

3.06e-0473914GO:0044091
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

TRPM4 TMC2 PSEN1 PSEN2 GPER1 SLC24A3 CATSPER3 ITPR1

3.41e-04392918GO:0070588
GeneOntologyBiologicalProcesssynaptic signaling

GABRD NLGN3 NLGN4X PSEN1 PSEN2 GPER1 NLGN4Y RAPGEF4 TACR2 GRIK1 HMGCR CHRM3 ITPR1

3.43e-049769113GO:0099536
GeneOntologyBiologicalProcesscellular homeostasis

TRPM4 PSEN1 PSEN2 GPER1 SLC31A2 SLC24A3 HMGCR ATP1B2 ATP1B3 SLC2A2 SLC22A12 DMXL1 ITPR1

3.61e-049819113GO:0019725
GeneOntologyBiologicalProcesspositive regulation of potassium ion import across plasma membrane

ATP1B2 ATP1B3

3.99e-047912GO:1903288
GeneOntologyBiologicalProcessdetection of virus

SERINC3 SERINC5

3.99e-047912GO:0009597
GeneOntologyBiologicalProcesspositive regulation of establishment of protein localization

TRPM4 PSEN1 GPER1 UBR5 RAPGEF4 CHRM3 SLC2A2 ITPR1

4.10e-04403918GO:1904951
GeneOntologyBiologicalProcesscalcium ion transport

TRPM4 TMC2 PSEN1 PSEN2 GPER1 SRL SLC24A3 CATSPER3 ITPR1

4.13e-04509919GO:0006816
GeneOntologyBiologicalProcessregulation of smooth muscle contraction

GPER1 TACR2 TACR3 CHRM3

4.14e-0479914GO:0006940
GeneOntologyBiologicalProcessintracellular chemical homeostasis

TRPM4 PSEN1 PSEN2 GPER1 SLC31A2 SLC24A3 HMGCR ATP1B2 ATP1B3 SLC2A2 DMXL1 ITPR1

4.16e-048669112GO:0055082
GeneOntologyBiologicalProcessorganic cation transport

PSEN1 SLC22A2 SERINC3 TACR2 SERINC5

4.59e-04145915GO:0015695
GeneOntologyCellularComponentsymmetric, GABA-ergic, inhibitory synapse

NLGN3 NLGN4X NLGN4Y

3.18e-074913GO:0098983
GeneOntologyCellularComponentendoplasmic reticulum membrane

SLC37A1 PSEN1 PSEN2 ABCB9 GPER1 TMEM259 SERINC1 PGAP2 HHAT UGT3A1 ELOVL3 SRL ATP11C HACD4 ATP10B HMGCR RNF175 CHRM3 PIGO ITPR1

5.57e-0712939120GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

SLC37A1 PSEN1 PSEN2 ABCB9 GPER1 TMEM259 SERINC1 PGAP2 HHAT UGT3A1 ELOVL3 SRL ATP11C HACD4 ATP10B HMGCR RNF175 CHRM3 PIGO ITPR1

5.99e-0712999120GO:0098827
GeneOntologyCellularComponentdendrite

USP50 GABRD NLGN3 BRINP3 AGO2 NLGN4X PSEN1 GPER1 NLGN4Y RAPGEF4 GRIK1 TACR3 CHRM3 DICER1 AR ITPR1

8.21e-078589116GO:0030425
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

SLC37A1 PSEN1 PSEN2 ABCB9 GPER1 TMEM259 SERINC1 PGAP2 HHAT UGT3A1 ELOVL3 SRL ATP11C HACD4 ATP10B HMGCR RNF175 CHRM3 PIGO ITPR1

8.37e-0713279120GO:0042175
GeneOntologyCellularComponentdendritic tree

USP50 GABRD NLGN3 BRINP3 AGO2 NLGN4X PSEN1 GPER1 NLGN4Y RAPGEF4 GRIK1 TACR3 CHRM3 DICER1 AR ITPR1

8.47e-078609116GO:0097447
GeneOntologyCellularComponentbasolateral plasma membrane

ABCC1 SLC16A1 SLC22A2 FRMPD2 RAPGEF4 SLC13A3 ATP1B3 CHRM3 SLC2A2 SLC16A8

1.32e-063209110GO:0016323
GeneOntologyCellularComponentapical plasma membrane

ABCC1 SLC13A1 SLC16A1 SLC17A1 SLC22A2 RAPGEF4 DRAM2 ATP1B2 ATP1B3 SLC2A2 SLC16A8 SLC22A12

1.33e-064879112GO:0016324
GeneOntologyCellularComponentapical part of cell

ABCC1 SLC13A1 SLC16A1 SLC17A1 SLC22A2 FRMPD2 RAPGEF4 DRAM2 ATP1B2 ATP1B3 SLC2A2 SLC16A8 SLC22A12

1.68e-065929113GO:0045177
GeneOntologyCellularComponentbasal plasma membrane

ABCC1 SLC16A1 SLC22A2 FRMPD2 RAPGEF4 SLC13A3 ATP1B3 CHRM3 SLC2A2 SLC16A8

3.25e-063549110GO:0009925
GeneOntologyCellularComponentsomatodendritic compartment

USP50 GABRD TRPM4 NLGN3 BRINP3 AGO2 NLGN4X PSEN1 PSEN2 GPER1 NLGN4Y RAPGEF4 GRIK1 TACR3 CHRM3 DICER1 AR ITPR1

4.83e-0612289118GO:0036477
GeneOntologyCellularComponentbasal part of cell

ABCC1 SLC16A1 SLC22A2 FRMPD2 RAPGEF4 SLC13A3 ATP1B3 CHRM3 SLC2A2 SLC16A8

5.81e-063789110GO:0045178
GeneOntologyCellularComponentRISC-loading complex

AGO2 AGO4 DICER1

9.37e-0610913GO:0070578
GeneOntologyCellularComponentneuron to neuron synapse

USP50 NLGN3 NLGN4X GPER1 NLGN4Y RAPGEF4 GRIK1 ATP1B2 CHRM3 DICER1 ITPR1

1.68e-055239111GO:0098984
GeneOntologyCellularComponentsymmetric synapse

NLGN3 NLGN4X NLGN4Y

2.21e-0513913GO:0032280
GeneOntologyCellularComponentasymmetric synapse

USP50 NLGN3 NLGN4X GPER1 NLGN4Y RAPGEF4 GRIK1 CHRM3 DICER1 ITPR1

4.29e-054779110GO:0032279
GeneOntologyCellularComponentsynaptic membrane

GABRD NLGN3 NLGN4X PSEN1 PSEN2 GPER1 NLGN4Y SLC22A2 GRIK1 CHRM3 ITPR1

4.54e-055839111GO:0097060
GeneOntologyCellularComponentpostsynaptic specialization

USP50 NLGN3 NLGN4X GPER1 NLGN4Y RAPGEF4 GRIK1 CHRM3 DICER1 ITPR1

6.69e-055039110GO:0099572
GeneOntologyCellularComponentasymmetric, glutamatergic, excitatory synapse

NLGN3 NLGN4X NLGN4Y

1.51e-0424913GO:0098985
GeneOntologyCellularComponentpostsynaptic density

USP50 NLGN4X GPER1 NLGN4Y RAPGEF4 GRIK1 CHRM3 DICER1 ITPR1

1.53e-04451919GO:0014069
GeneOntologyCellularComponentinhibitory synapse

NLGN3 NLGN4X NLGN4Y

3.28e-0431913GO:0060077
GeneOntologyCellularComponentgamma-secretase complex

PSEN1 PSEN2

3.88e-047912GO:0070765
GeneOntologyCellularComponentpostsynapse

USP50 GABRD NLGN3 AGO2 NLGN4X PSEN1 GPER1 NLGN4Y RAPGEF4 GRIK1 CHRM3 DICER1 ITPR1

4.52e-0410189113GO:0098794
GeneOntologyCellularComponentendoribonuclease complex

AGO2 AGO4 DICER1

5.57e-0437913GO:1902555
GeneOntologyCellularComponenttransporter complex

GABRD TRPM4 CLCN1 ATP11C ATP10B CATSPER3 GRIK1 ATP1B2 ATP1B3

6.54e-04550919GO:1990351
GeneOntologyCellularComponentcell body

GABRD TRPM4 NLGN3 BRINP3 PSEN1 PSEN2 GPER1 RAPGEF4 GRIK1 TACR3 ATP1B2 ITPR1

6.88e-049299112GO:0044297
GeneOntologyCellularComponentGABA-ergic synapse

GABRD NLGN3 NLGN4X NLGN4Y ITPR1

7.55e-04164915GO:0098982
GeneOntologyCellularComponentglutamatergic synapse

GABRD NLGN3 AGO2 NLGN4X PSEN1 PSEN2 NLGN4Y RAPGEF4 GRIK1 CHRM3 DICER1

8.33e-048179111GO:0098978
GeneOntologyCellularComponentendonuclease complex

AGO2 AGO4 DICER1

8.68e-0443913GO:1905348
GeneOntologyCellularComponentneuronal cell body

GABRD TRPM4 NLGN3 BRINP3 PSEN1 PSEN2 GPER1 RAPGEF4 GRIK1 TACR3 ITPR1

9.94e-048359111GO:0043025
GeneOntologyCellularComponentsodium:potassium-exchanging ATPase complex

ATP1B2 ATP1B3

1.20e-0312912GO:0005890
GeneOntologyCellularComponentexcitatory synapse

NLGN3 NLGN4X NLGN4Y RAPGEF4

1.23e-03107914GO:0060076
GeneOntologyCellularComponentpresynaptic membrane

PSEN1 PSEN2 GPER1 SLC22A2 GRIK1 CHRM3

1.33e-03277916GO:0042734
GeneOntologyCellularComponentpresynapse

NLGN3 NLGN4X PSEN1 PSEN2 GPER1 NLGN4Y SLC22A2 RAPGEF4 GRIK1 CHRM3 ITPR1

1.60e-038869111GO:0098793
GeneOntologyCellularComponentphospholipid-translocating ATPase complex

ATP11C ATP10B

1.65e-0314912GO:1990531
GeneOntologyCellularComponentDNA replication factor A complex

SMARCAL1 HELB

1.65e-0314912GO:0005662
GeneOntologyCellularComponentpostsynaptic specialization membrane

NLGN3 NLGN4X NLGN4Y GRIK1 CHRM3

1.86e-03201915GO:0099634
GeneOntologyCellularComponentpostsynaptic membrane

GABRD NLGN3 NLGN4X GPER1 NLGN4Y GRIK1 CHRM3

1.95e-03405917GO:0045211
GeneOntologyCellularComponentdistal axon

PSEN1 GPER1 RAPGEF4 GRIK1 CHRM3 DICER1 EXOC8

2.91e-03435917GO:0150034
GeneOntologyCellularComponentnuclear envelope

RANBP17 GMCL1 GMCL2 PSEN1 PSEN2 GPER1 NUP210L ITPR1

3.06e-03560918GO:0005635
GeneOntologyCellularComponentglycinergic synapse

NLGN4X NLGN4Y

3.38e-0320912GO:0098690
GeneOntologyCellularComponentnuclear replisome

SMARCAL1 HELB

4.47e-0323912GO:0043601
GeneOntologyCellularComponentphotoreceptor inner segment

RAPGEF4 DRAM2 ATP1B2

4.80e-0378913GO:0001917
GeneOntologyCellularComponentpostsynaptic density membrane

NLGN4X NLGN4Y GRIK1 CHRM3

4.93e-03157914GO:0098839
GeneOntologyCellularComponentreplisome

SMARCAL1 HELB

5.27e-0325912GO:0030894
GeneOntologyCellularComponentsodium channel complex

TRPM4 GRIK1

7.05e-0329912GO:0034706
GeneOntologyCellularComponentlateral plasma membrane

ABCC1 SLC16A1 ATP1B2

7.14e-0390913GO:0016328
GeneOntologyCellularComponenttransmembrane transporter complex

GABRD TRPM4 CLCN1 CATSPER3 GRIK1 ATP1B2 ATP1B3

7.83e-03523917GO:1902495
DomainMFS_dom

SLC37A1 SLC16A1 SLC45A3 SLC17A1 SLC22A2 SLC2A2 SLC16A8 SLC22A12

2.47e-07134898IPR020846
DomainMFS

SLC37A1 SLC16A1 SLC17A1 SLC22A2 SLC2A2 SLC16A8 SLC22A12

8.29e-07108897PS50850
DomainNlgn

NLGN3 NLGN4X NLGN4Y

1.04e-065893IPR000460
DomainTDE1/TMS

SERINC1 SERINC3 SERINC5

1.04e-065893IPR005016
DomainSerinc

SERINC1 SERINC3 SERINC5

1.04e-065893PF03348
DomainMFS_1

SLC37A1 SLC16A1 SLC45A3 SLC17A1 SLC16A8 SLC22A12

1.78e-0677896PF07690
DomainMFS

SLC37A1 SLC16A1 SLC45A3 SLC17A1 SLC16A8 SLC22A12

1.78e-0677896IPR011701
DomainPAZ

AGO2 AGO4 DICER1

8.61e-069893PS50821
DomainPAZ

AGO2 AGO4 DICER1

8.61e-069893SM00949
DomainPAZ_dom

AGO2 AGO4 DICER1

8.61e-069893IPR003100
DomainPAZ

AGO2 AGO4 DICER1

8.61e-069893PF02170
DomainPeptidase_A22A

PSEN1 PSEN2

2.25e-052892IPR001108
DomainNLGN4

NLGN4X NLGN4Y

2.25e-052892IPR030025
DomainPresenilin

PSEN1 PSEN2

2.25e-052892PF01080
DomainCarboxylesterase_B_CS

NLGN3 NLGN4X NLGN4Y

2.89e-0513893IPR019819
DomainCARBOXYLESTERASE_B_2

NLGN3 NLGN4X NLGN4Y

3.67e-0514893PS00941
DomainCOesterase

NLGN3 NLGN4X NLGN4Y

3.67e-0514893PF00135
DomainCarbesteraseB

NLGN3 NLGN4X NLGN4Y

3.67e-0514893IPR002018
DomainNeurokn_rcpt

TACR2 TACR3

6.72e-053892IPR001681
DomainArgonaute_N

AGO2 AGO4

1.34e-044892IPR032474
DomainArgonaute_Mid_dom

AGO2 AGO4

1.34e-044892IPR032473
DomainArgoL2

AGO2 AGO4

1.34e-044892IPR032472
DomainArgoN

AGO2 AGO4

1.34e-044892PF16486
DomainArgoMid

AGO2 AGO4

1.34e-044892PF16487
DomainArgoL2

AGO2 AGO4

1.34e-044892PF16488
DomainABC_membrane

ABCC1 ABCB10 ABCB9

1.97e-0424893PF00664
DomainNa/sul_symport

SLC13A1 SLC13A3

2.22e-045892IPR001898
DomainNa_sulph_symp

SLC13A1 SLC13A3

2.22e-045892PF00939
DomainNa/K_ATPase_sub_beta

ATP1B2 ATP1B3

2.22e-045892IPR000402
DomainNa_K-ATPase

ATP1B2 ATP1B3

2.22e-045892PF00287
DomainATPASE_NA_K_BETA_1

ATP1B2 ATP1B3

2.22e-045892PS00390
DomainDUF1785

AGO2 AGO4

2.22e-045892SM01163
DomainMCT

SLC16A1 SLC16A8

2.22e-045892IPR004743
DomainABC_TM1F

ABCC1 ABCB10 ABCB9

3.14e-0428893PS50929
DomainABC1_TM_dom

ABCC1 ABCB10 ABCB9

3.14e-0428893IPR011527
DomainArgoL1

AGO2 AGO4

3.33e-046892PF08699
DomainFrag1

PGAP2 DRAM2

3.33e-046892PF10277
DomainArgoL1

AGO2 AGO4

3.33e-046892IPR014811
DomainFrag1/DRAM/Sfk1

PGAP2 DRAM2

3.33e-046892IPR019402
DomainPSN

PSEN1 PSEN2

4.64e-047892SM00730
DomainPreselin/SPP

PSEN1 PSEN2

4.64e-047892IPR006639
DomainPIWI

AGO2 AGO4

6.17e-048892PS50822
DomainPiwi

AGO2 AGO4

6.17e-048892SM00950
DomainPiwi

AGO2 AGO4

6.17e-048892IPR003165
DomainPiwi

AGO2 AGO4

6.17e-048892PF02171
DomainMFS_sugar_transport-like

SLC22A2 SLC2A2 SLC22A12

6.67e-0436893IPR005828
DomainSugar_tr

SLC22A2 SLC2A2 SLC22A12

6.67e-0436893PF00083
DomainABC_transporter_CS

ABCC1 ABCB10 ABCB9

1.05e-0342893IPR017871
DomainABC_tran

ABCC1 ABCB10 ABCB9

1.55e-0348893PF00005
DomainABC_TRANSPORTER_2

ABCC1 ABCB10 ABCB9

1.55e-0348893PS50893
DomainABC_TRANSPORTER_1

ABCC1 ABCB10 ABCB9

1.64e-0349893PS00211
DomainABC_transporter-like

ABCC1 ABCB10 ABCB9

1.74e-0350893IPR003439
DomainP_typ_ATPase_c

ATP11C ATP10B

1.97e-0314892IPR032630
DomainP-type_ATPase_N

ATP11C ATP10B

1.97e-0314892IPR032631
DomainP-type_ATPase_IV

ATP11C ATP10B

1.97e-0314892IPR006539
DomainPhoLip_ATPase_C

ATP11C ATP10B

1.97e-0314892PF16212
DomainPhoLip_ATPase_N

ATP11C ATP10B

1.97e-0314892PF16209
DomainSUGAR_TRANSPORT_2

SLC22A2 SLC2A2

2.91e-0317892PS00217
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

TRPM4 ABCC1 CLCN1 ABCB10 SLC13A1 ABCB9 SLC16A1 SLC45A3 SLC17A1 SLC22A2 PARL SLC24A3 ATP11C ATP10B SLC13A3 ATP1B2 ATP1B3 UNC79 SLC2A2 SLC16A8 SLC22A12

1.19e-117366721M27287
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

TRPM4 ABCC1 CLCN1 SLC13A1 ABCB9 SLC16A1 SLC45A3 SLC17A1 SLC22A2 PARL SLC24A3 ATP11C ATP10B SLC13A3 ATP1B2 ATP1B3 UNC79 SLC2A2 SLC16A8 SLC22A12

2.48e-116816720MM14985
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC13A1 SLC16A1 SLC45A3 SLC17A1 SLC22A2 SLC24A3 SLC13A3 SLC2A2 SLC16A8 SLC22A12

1.66e-072386710MM15076
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC13A1 SLC16A1 SLC45A3 SLC17A1 SLC22A2 SLC24A3 SLC13A3 SLC2A2 SLC16A8 SLC22A12

2.53e-072496710M5988
PathwayBIOCARTA_DICER_PATHWAY

AGO2 AGO4 DICER1

1.02e-065673M22079
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC13A1 SLC16A1 SLC22A2 SLC13A3 SLC16A8 SLC22A12

1.54e-0676676MM15072
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC13A1 SLC16A1 SLC22A2 SLC13A3 SLC16A8 SLC22A12

2.79e-0684676M27334
PathwayREACTOME_BASIGIN_INTERACTIONS

SLC16A1 ATP1B2 ATP1B3 SLC16A8

4.61e-0624674MM17215
PathwayREACTOME_BASIGIN_INTERACTIONS

SLC16A1 ATP1B2 ATP1B3 SLC16A8

5.47e-0625674M4974
PathwayREACTOME_SERINE_BIOSYNTHESIS

SERINC1 SERINC3 SERINC5

8.45e-069673M27959
PathwayREACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS

AGO2 AGO4 DICER1

8.45e-069673M27340
PathwayREACTOME_SERINE_BIOSYNTHESIS

SERINC1 SERINC3 SERINC5

8.45e-069673MM15707
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPM4 CLCN1 ATP11C ATP10B ATP1B2 ATP1B3 UNC79

1.94e-05176677MM15718
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPM4 CLCN1 ATP11C ATP10B ATP1B2 ATP1B3 UNC79

2.50e-05183677M997
PathwayREACTOME_SIGNALING_BY_TGFBR3

AGO2 AGO4 PSEN1 PSEN2

8.41e-0549674M48250
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

TACR2 TACR3 CHRM3 ITPR1

9.10e-0550674M47951
PathwayREACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS

AGO2 AGO4 DICER1

9.42e-0519673M48238
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP11C ATP10B ATP1B2 ATP1B3

1.32e-0455674M971
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP11C ATP10B ATP1B2 ATP1B3

1.52e-0457674MM15643
PathwayREACTOME_MICRORNA_MIRNA_BIOGENESIS

AGO2 AGO4 DICER1

2.19e-0425673M712
PathwayREACTOME_SODIUM_COUPLED_SULPHATE_DI_AND_TRI_CARBOXYLATE_TRANSPORTERS

SLC13A1 SLC13A3

2.20e-045672MM15099
PathwayREACTOME_SODIUM_COUPLED_SULPHATE_DI_AND_TRI_CARBOXYLATE_TRANSPORTERS

SLC13A1 SLC13A3

2.20e-045672M27354
PathwayREACTOME_TACHYKININ_RECEPTORS_BIND_TACHYKININS

TACR2 TACR3

2.20e-045672M27277
PathwayREACTOME_TACHYKININ_RECEPTORS_BIND_TACHYKININS

TACR2 TACR3

2.20e-045672MM14977
PathwayWP_FRAGILE_X_SYNDROME

GABRD AGO2 SLC16A1 DICER1 ITPR1

2.71e-04121675M39804
PathwayWP_EXRNA_MECHANISM_OF_ACTION_AND_BIOGENESIS

AGO2 DICER1

3.30e-046672M39578
PathwayREACTOME_MICRORNA_MIRNA_BIOGENESIS

AGO2 AGO4

3.30e-046672MM14818
PathwayREACTOME_PROTON_COUPLED_MONOCARBOXYLATE_TRANSPORT

SLC16A1 SLC16A8

3.30e-046672MM17217
PathwayREACTOME_PROTON_COUPLED_MONOCARBOXYLATE_TRANSPORT

SLC16A1 SLC16A8

3.30e-046672M27355
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

AGO2 AGO4

3.30e-046672MM15083
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

AGO2 AGO4

4.60e-047672M46421
PathwayREACTOME_NEUREXINS_AND_NEUROLIGINS

NLGN3 NLGN4X NLGN4Y

4.61e-0432673MM15326
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

RAPGEF4 CHRM3 SLC2A2 ITPR1

5.10e-0478674M1921
PathwayREACTOME_NONCANONICAL_ACTIVATION_OF_NOTCH3

PSEN1 PSEN2

6.12e-048672M27887
PathwayREACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS

AGO2 AGO4

6.12e-048672MM15082
PathwayREACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION

AGO2 AGO4

7.84e-049672M27810
PathwayREACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION

AGO2 AGO4

7.84e-049672M46436
PathwayREACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS

AGO2 AGO4

9.77e-0410672M48013
PathwayKEGG_ABC_TRANSPORTERS

ABCC1 ABCB10 ABCB9

1.18e-0344673M11911
PathwayREACTOME_NOTCH4_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

PSEN1 PSEN2

1.19e-0311672M27882
PathwayREACTOME_TGFBR3_PTM_REGULATION

PSEN1 PSEN2

1.19e-0311672M48251
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

PSEN1 PSEN2

1.19e-0311672M47865
PathwayWP_INCLUSION_BODY_MYOSITIS

PSEN1 PSEN2

1.19e-0311672M42545
PathwayREACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR

PSEN1 PSEN2

1.19e-0311672M2661
PathwayREACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT

SLC22A2 SLC22A12

1.42e-0312672MM15192
PathwayWP_TROP2_REGULATORY_SIGNALING

ABCC1 PSEN1 PSEN2

1.62e-0349673M46458
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

PSEN1 ITPR1

1.68e-0313672M47696
PathwayREACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION

AGO2 AGO4

1.68e-0313672M46434
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

RAPGEF4 CHRM3 SLC2A2 ITPR1

1.72e-03108674M17034
PathwayREACTOME_DRUG_ADME

ABCC1 SLC16A1 SLC22A2 UGT3A1

1.78e-03109674M45012
PathwayREACTOME_ION_HOMEOSTASIS

ATP1B2 ATP1B3 ITPR1

2.14e-0354673M27460
PathwayREACTOME_ION_HOMEOSTASIS

ATP1B2 ATP1B3 ITPR1

2.14e-0354673MM15202
PathwayREACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT

SLC22A2 SLC22A12

2.25e-0315672M888
PathwayREACTOME_NEUREXINS_AND_NEUROLIGINS

NLGN3 NLGN4X NLGN4Y

2.38e-0356673M27616
PathwayREACTOME_DRUG_ADME

ABCC1 SLC16A1 SLC22A2 UGT3A1

2.46e-03119674MM15692
PathwayWP_PROXIMAL_TUBULE_TRANSPORT

SLC22A2 SLC13A3 SLC2A2

2.50e-0357673M39812
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

PSEN1 PSEN2

2.56e-0316672M47695
PathwayREACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS

PSEN1 PSEN2

2.56e-0316672M7257
PathwayREACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY

AGO2 AGO4

2.89e-0317672M27788
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

RAPGEF4 SLC2A2 ITPR1

3.03e-0361673MM15071
PathwayREACTOME_CA2_PATHWAY

AGO2 AGO4 ITPR1

3.18e-0362673M27321
PathwayWP_NRXN1_DELETION_SYNDROME

NLGN3 NLGN4X

3.24e-0318672M48098
PathwayREACTOME_CELLULAR_HEXOSE_TRANSPORT

SLC45A3 SLC2A2

3.61e-0319672MM14718
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

NLGN3 NLGN4X NLGN4Y

3.96e-0367673MM15327
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

CHRM3 ITPR1

4.00e-0320672M47688
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

CHRM3 ITPR1

4.41e-0321672M47689
PathwayREACTOME_CELLULAR_HEXOSE_TRANSPORT

SLC45A3 SLC2A2

4.41e-0321672M27058
PathwayREACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

PSEN1 PSEN2

4.83e-0322672M27210
PathwayREACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS

ELOVL3 HACD4

4.83e-0322672MM15451
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

RAPGEF4 SLC2A2 ITPR1

4.84e-0372673MM14631
Pubmed

Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.

NLGN3 NLGN4X NLGN4Y

1.79e-08392332011705
Pubmed

Analysis of the neuroligin 4Y gene in patients with autism.

NLGN3 NLGN4X NLGN4Y

1.79e-08392318628683
Pubmed

Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.

NLGN3 NLGN4X NLGN4Y

7.15e-08492312669065
Pubmed

Homodimerization and isoform-specific heterodimerization of neuroligins.

NLGN3 NLGN4X NLGN4Y

7.15e-08492322671294
Pubmed

Ultrasonic vocalizations in mouse models for speech and socio-cognitive disorders: insights into the evolution of vocal communication.

NLGN3 NLGN4X NLGN4Y

7.15e-08492320579107
Pubmed

Analysis of four neuroligin genes as candidates for autism.

NLGN3 NLGN4X NLGN4Y

7.15e-08492316077734
Pubmed

Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.

NLGN3 NLGN4X NLGN4Y

7.15e-08492317292328
Pubmed

Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells.

AGO2 AGO4 DICER1

1.78e-07592319393748
Pubmed

Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.

NLGN3 NLGN4X NLGN4Y

1.78e-07592337865312
Pubmed

Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.

AGO2 AGO4 DICER1

1.78e-07592312526743
Pubmed

Differential expression of components of the microRNA machinery during mouse organogenesis.

AGO2 AGO4 DICER1

1.78e-07592316036130
Pubmed

Synapse formation: if it looks like a duck and quacks like a duck ...

NLGN3 NLGN4X NLGN4Y

1.78e-07592310996085
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

GABRD SLC37A1 TRPM4 TMEM42 SLC16A1 SLC31A2 TMEM259 SERINC3 GRIK1 SERINC5 TAFA5 CHRM3

3.21e-07697921228298427
Pubmed

The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?

NLGN3 NLGN4X NLGN4Y

3.56e-07692321838267
Pubmed

Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.

NLGN3 NLGN4X NLGN4Y

3.56e-07692329724786
Pubmed

Blood-Brain Barrier: From Physiology to Disease and Back.

ABCC1 SLC16A1 SLC22A2 SLC24A3 SLC13A3 ATP1B2

3.79e-0710592630280653
Pubmed

Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.

NLGN3 NLGN4X NLGN4Y

9.94e-07892330871858
Pubmed

Suppression of microRNA Activity in Kidney Collecting Ducts Induces Partial Loss of Epithelial Phenotype and Renal Fibrosis.

AGO2 AGO4 DICER1

9.94e-07892329021386
Pubmed

Identification of eight members of the Argonaute family in the human genome.

AGO2 AGO4 DICER1

1.49e-06992312906857
Pubmed

Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.

NLGN3 NLGN4X NLGN4Y

1.49e-06992323010509
Pubmed

SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.

NLGN3 NLGN4X NLGN4Y

2.91e-061192332973045
Pubmed

Behavioral phenotypes of genetic mouse models of autism.

NLGN3 NLGN4X NLGN4Y

2.91e-061192326403076
Pubmed

Advancing the understanding of autism disease mechanisms through genetics.

NLGN3 NLGN4X NLGN4Y

5.03e-061392327050589
Pubmed

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.

PSEN1 PSEN2

6.92e-06292221285369
Pubmed

Novel PSEN1 and PSEN2 Mutations Identified in Sporadic Early-onset Alzheimer Disease and Posterior Cortical Atrophy.

PSEN1 PSEN2

6.92e-06292233973882
Pubmed

Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12.

PSEN1 PSEN2

6.92e-06292212460542
Pubmed

Alzheimer's Disease Associated Presenilin 1 and 2 Genes Dysregulation in Neonatal Lymphocytes Following Perinatal Asphyxia.

PSEN1 PSEN2

6.92e-06292234067945
Pubmed

Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus.

PSEN1 PSEN2

6.92e-06292236710361
Pubmed

Association Analysis of Noncoding Variants in Neuroligins 3 and 4X Genes with Autism Spectrum Disorder in an Italian Cohort.

NLGN3 NLGN4X

6.92e-06292227782075
Pubmed

Not all neuroligin 3 and 4X missense variants lead to significant functional inactivation.

NLGN3 NLGN4X

6.92e-06292228948087
Pubmed

Binding of transcription factors to Presenilin 1 and 2 promoter cis-acting elements varies during the development of mouse cerebral cortex.

PSEN1 PSEN2

6.92e-06292227177724
Pubmed

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts.

PSEN1 PSEN2

6.92e-06292211715026
Pubmed

Clinical Phenotype and Mutation Spectrum of Alzheimer's Disease with Causative Genetic Mutation in a Chinese Cohort.

PSEN1 PSEN2

6.92e-06292234102969
Pubmed

Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations.

PSEN1 PSEN2

6.92e-06292223365231
Pubmed

Changes in cholesterol metabolism are associated with PS1 and PS2 gene regulation in SK-N-BE.

PSEN1 PSEN2

6.92e-06292217401156
Pubmed

Mouse germ cell-less as an essential component for nuclear integrity.

GMCL1 GMCL2

6.92e-06292212556490
Pubmed

3-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3.

SLC22A2 SLC13A3

6.92e-06292217356845
Pubmed

Identification of Structural Calcium Binding Sites in Membrane-Bound Presenilin 1 and 2.

PSEN1 PSEN2

6.92e-06292232420742
Pubmed

Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism.

NLGN3 NLGN4X

6.92e-06292216648374
Pubmed

A substitution involving the NLGN4 gene associated with autistic behavior in the Greek population.

NLGN3 NLGN4X

6.92e-06292219645625
Pubmed

Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro.

PSEN1 PSEN2

6.92e-06292233413468
Pubmed

Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.

PSEN1 PSEN2

6.92e-06292231167792
Pubmed

Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism.

PSEN1 PSEN2

6.92e-06292218367332
Pubmed

Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.

PSEN1 PSEN2

6.92e-06292229078389
Pubmed

Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.

PSEN1 PSEN2

6.92e-06292219834068
Pubmed

Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death.

PSEN1 PSEN2

6.92e-06292218971484
Pubmed

Presenilin Gene Mutation-associated Psychosis: Phenotypic Characteristics and Clinical Implications.

PSEN1 PSEN2

6.92e-06292238227890
Pubmed

Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands.

NLGN3 NLGN4X

6.92e-06292215274046
Pubmed

Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction.

ATP1B2 DMXL1

6.92e-06292216865689
Pubmed

Epigenetic regulation of presenilin 1 and 2 in the cerebral cortex of mice during development.

PSEN1 PSEN2

6.92e-06292225652771
Pubmed

MicroRNA-Independent Modulation of DICER1 Expression by hAgo2.

AGO2 DICER1

6.92e-06292232778571
Pubmed

Loss of presenilin function enhances tau phosphorylation and aggregation in mice.

PSEN1 PSEN2

6.92e-06292234593029
Pubmed

Loss of Spatial Memory, Learning, and Motor Function During Normal Aging Is Accompanied by Changes in Brain Presenilin 1 and 2 Expression Levels.

PSEN1 PSEN2

6.92e-06292225204494
Pubmed

Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.

NLGN4X NLGN4Y

6.92e-06292223183221
Pubmed

Decreased AGO2 and DCR1 in PBMCs from War Veterans with PTSD leads to diminished miRNA resulting in elevated inflammation.

AGO2 DICER1

6.92e-06292228850112
Pubmed

Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.

NLGN4X NLGN4Y

6.92e-06292224855039
Pubmed

Increased inflammatory response both in brain and in periphery in presenilin 1 and presenilin 2 conditional double knock-out mice.

PSEN1 PSEN2

6.92e-06292219584449
Pubmed

Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway.

PSEN1 PSEN2

6.92e-06292228619096
Pubmed

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

PSEN1 PSEN2

6.92e-0629228574969
Pubmed

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

PSEN1 PSEN2

6.92e-06292212846562
Pubmed

Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.

NLGN4X NLGN4Y

6.92e-06292237001827
Pubmed

HIV-cell membrane fusion intermediates are restricted by Serincs as revealed by cryo-electron and TIRF microscopy.

SERINC3 SERINC5

6.92e-06292232788212
Pubmed

Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.

PSEN1 PSEN2

6.92e-06292237864790
Pubmed

Ibuprofen partially attenuates neurodegenerative symptoms in presenilin conditional double-knockout mice.

PSEN1 PSEN2

6.92e-06292224699228
Pubmed

Identification of an axotomy-induced glycosylated protein, AIGP1, possibly involved in cell death triggered by endoplasmic reticulum-Golgi stress.

SERINC3 SERINC5

6.92e-06292212486168
Pubmed

The gain-of-function enhancement of IP3-receptor channel gating by familial Alzheimer's disease-linked presenilin mutants increases the open probability of mitochondrial permeability transition pore.

PSEN1 ITPR1

6.92e-06292227184076
Pubmed

Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells.

PSEN1 PSEN2

6.92e-06292215287885
Pubmed

A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.

PSEN1 PSEN2

6.92e-06292215537629
Pubmed

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.

PSEN1 PSEN2

6.92e-06292212885769
Pubmed

Age and sex dependent alteration in presenilin expression in mouse cerebral cortex.

PSEN1 PSEN2

6.92e-06292217874292
Pubmed

Genome-wide identification of targets and function of individual MicroRNAs in mouse embryonic stem cells.

AGO2 DICER1

6.92e-06292220975942
Pubmed

Two homologous genes causing early-onset familial Alzheimer's disease.

PSEN1 PSEN2

6.92e-0629229246482
Pubmed

A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.

PSEN1 PSEN2

6.92e-06292216103124
Pubmed

Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells.

GMCL1 GMCL2

6.92e-06292210448096
Pubmed

Dimorphic effects of Notch signaling in bone homeostasis.

PSEN1 PSEN2

6.92e-06292218297084
Pubmed

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.

PSEN1 PSEN2

6.92e-06292215128703
Pubmed

Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization.

PSEN1 PSEN2

6.92e-06292221914807
Pubmed

Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5.

SERINC3 SERINC5

6.92e-06292231186327
Pubmed

Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes.

ABCB10 ABCB9

6.92e-06292210748049
Pubmed

Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice.

PSEN1 PSEN2

6.92e-06292217614943
Pubmed

Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction.

PSEN1 PSEN2

6.92e-06292220854432
Pubmed

Down-regulation of Dicer and Ago2 is associated with cell proliferation and apoptosis in prostate cancer.

AGO2 DICER1

6.92e-06292225135428
Pubmed

PSEN1 and PSEN2 gene expression in Alzheimer's disease brain: a new approach.

PSEN1 PSEN2

6.92e-06292224927704
Pubmed

Abnormalities in periodontal and salivary tissues in conditional presenilin 1 and presenilin 2 double knockout mice.

PSEN1 PSEN2

6.92e-06292220953898
Pubmed

No evidence for involvement of genetic variants in the X-linked neuroligin genes NLGN3 and NLGN4X in probands with autism spectrum disorder on high functioning level.

NLGN3 NLGN4X

6.92e-06292218189281
Pubmed

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.

PSEN1 PSEN2

6.92e-06292222002539
Pubmed

Presence of presenilin 1/2 affects the invasion and replication of Salmonella typhimurium.

PSEN1 PSEN2

6.92e-06292215922300
Pubmed

Enhanced oxidative stress is an early event during development of Alzheimer-like pathologies in presenilin conditional knock-out mice.

PSEN1 PSEN2

6.92e-06292218539391
Pubmed

Presenilin mutations in Alzheimer's disease.

PSEN1 PSEN2

6.92e-0629229521418
Pubmed

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.

PSEN1 PSEN2

6.92e-0629229450754
Pubmed

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.

PSEN1 PSEN2

6.92e-06292222505025
Pubmed

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation.

PSEN1 PSEN2

6.92e-0629229298903
Pubmed

Circadian rhythm sleep disorders and time-of-day-dependent memory deficiency in Presenilin1/2 conditional knockout mice with long noncoding RNA expression profiling changes.

PSEN1 PSEN2

6.92e-06292236805914
Pubmed

Disorder-associated mutations lead to functional inactivation of neuroligins.

NLGN3 NLGN4X

6.92e-06292215150161
Pubmed

Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients.

NLGN3 NLGN4X

6.92e-06292215622415
Pubmed

Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice.

PSEN1 PSEN2

6.92e-06292222496554
Pubmed

Novel role of presenilins in maturation and transport of integrin beta 1.

PSEN1 PSEN2

6.92e-06292218293935
Pubmed

gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.

PSEN1 PSEN2

6.92e-06292216135086
Pubmed

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef.

SERINC3 SERINC5

6.92e-06292226416733
Pubmed

HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation.

SERINC3 SERINC5

6.92e-06292226416734
GeneFamilySolute carriers

SLC37A1 SLC26A8 SLC13A1 SLC16A1 SLC31A2 SLC45A3 SLC17A1 SLC22A2 SLC24A3 SLC13A3 SLC2A2 SLC16A8 SLC22A12

3.46e-103955913752
GeneFamilyTachykinin receptors

TACR2 TACR3

3.13e-053592258
GeneFamilyATPase Na+/K+ transporting subunits

ATP1B2 ATP1B3

2.18e-0475921208
GeneFamilyArgonaute/PIWI family

AGO2 AGO4

2.89e-048592408
GeneFamilyATP binding cassette subfamily B

ABCB10 ABCB9

5.65e-0411592806
GeneFamilyATPase phospholipid transporting

ATP11C ATP10B

1.07e-03155921210
ToppCellfacs-Kidney|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC13A1 SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC2A2 SLC22A12

5.99e-08168927d2f17a470e04f8f0edb111894027bcfc6ee1a12f
ToppCellCOVID-19-kidney-PCT-S1/S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC13A1 SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC2A2 SLC22A12

8.89e-0817892723a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCelldroplet-Kidney|droplet / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC13A1 SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC2A2 SLC22A12

9.60e-081809277e5f497699876ac8e1ce780626c6f5a1f6f5f079
ToppCellCOVID-19-kidney-Stressed_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC13A1 SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC2A2 SLC22A12

9.97e-081819276980ea624151da32b7f537f263e40fcb87a02e81
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC13A1 SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC2A2 SLC22A12

1.04e-07182927faf0dfa3adc2d2706b6942b5127093ccdc856447
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC13A1 SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC2A2 SLC22A12

1.04e-07182927be8dd52898525ce6632af0adc2801944f3ac10bd
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC13A1 SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC22A12

1.22e-06165926082f62f759a0b16ab56fad6dd4c4dd70b4f18a5c
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC13A1 SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC22A12

1.26e-061669268ab18c9d911eb3a9970bba7a769294b0927538f7
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC13A1 SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC22A12

1.26e-061669260868f45d8d39ad39b5cee5e81ac3dd4dc512775d
ToppCelldroplet-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC13A1 SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC22A12

1.35e-06168926dd48da83c32d41a62f80cd7e5e5c64e42776fa27
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC16A1 SLC17A1 SLC13A3 SLC2A2 SLC22A12

1.35e-06168926fa0d251693935116adf633d02b7ec4a295100865
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NLGN4X RARRES1 NLGN4Y SLC24A3 ATP10B SLC16A8

1.66e-061749269c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NLGN4X RARRES1 NLGN4Y SLC24A3 ATP10B SLC16A8

1.66e-06174926bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC2A2 SLC22A12

2.02e-06180926358923e4228035a3e90e2957392089219e90dcd7
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC13A1 SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC2A2

2.02e-06180926864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCellCOVID-19-kidney-PCT-S1/S2|kidney / Disease (COVID-19 only), tissue and cell type

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC2A2 SLC22A12

2.30e-06184926dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCellCOVID-19-kidney-Mito-rich_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC2A2 SLC22A12

2.37e-061859261bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

SLC13A1 SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC2A2

2.52e-06187926acd305475f3609800af0d7bc68d83ef41228080b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC2A2 SLC22A12

2.68e-0618992613fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCellCOVID-19-kidney-PCT-S2|kidney / Disease (COVID-19 only), tissue and cell type

KLHL29 SLC13A1 SLC17A1 SLC22A2 SLC13A3 AR

2.68e-061899260be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC2A2 SLC22A12

3.51e-0619892672733b6149b797ac11cc108bc80428b77fbbba78
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC2A2 SLC22A12

3.51e-06198926f23559ce6072e3c323f6791ff95269271b0f7ff1
ToppCellLPS_IL1RA-Hematopoietic_Myeloid-Granulocytic_cells-Mast-cells|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ABCC1 SLC45A3 HHAT SLC24A3 HACD4 CHRM3

3.71e-062009262200a621da1634728a49b1706e422e3e78b1f3bf
ToppCellEpithelial-Epithelial-B_(AT1-AT2-progenitors)|Epithelial / shred on cell class and cell subclass (v4)

BRINP3 MDN1 SMARCAL1 OTOP2 ITPR1

1.70e-05154925770712806e26f73456fb77a81aa4ef8ec78a21ea
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC17A1 SLC22A2 UGT3A1 UROC1 SLC22A12

2.59e-05168925b14fd50232887b6dca1f39014d43c6f66e5c3b5c
ToppCellfacs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC22A12

2.66e-05169925ee27bcfe3f9a295ec5fb0a375d77d1050e5cbaad
ToppCellfacs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC22A12

2.66e-05169925922086f218135b734b7d370b871923e50141edce
ToppCelldroplet-Kidney-nan-3m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC22A2 UGT3A1 SLC24A3 UROC1 SLC22A12

2.74e-05170925dd48fd3c5c67eb71183981f42975a538f12077c3
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC22A12

2.82e-0517192548fc4eca18b102b5ec5050f758281292ee8e10c6
ToppCelldroplet-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC22A12

2.82e-0517192505fcc72df50a380a913821b5781d9621df37d328
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC66A2 SLC13A1 SLC17A1 SLC13A3 SLC22A12

3.50e-0517992578fae47ec9bff4e0159a86a281e831d7f8ee925a
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_proximal_straight_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLGN3 SLC13A1 SLC17A1 SLC13A3 SLC22A12

3.60e-05180925b34d933cdabf692f02eaaf65c2aaca1fb9510627
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC13A3 UNC79 SLC2A2

3.60e-051809251363b3254470f6ff98630d1df83a1bdbacc137e0
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC13A3 UNC79 SLC22A12

3.69e-051819259542c19edc9bd2cba68c01c2a8407705398e3011
ToppCellfacs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC13A1 SLC17A1 SLC13A3 SLC2A2 SLC22A12

3.69e-05181925bec7076efe94898213a62db72d171d737949977e
ToppCellfacs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC13A1 SLC17A1 SLC13A3 SLC2A2 SLC22A12

3.69e-05181925cf149b30b814cf87c9e923ef502cadf7fe4a3597
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC13A3 UNC79 SLC22A12

3.69e-051819258f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC13A3 SLC2A2 SLC22A12

3.79e-05182925e1e58176f533092b6b974ca1ce8b02192a6e193d
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC17A1 SLC22A2 UGT3A1 SLC13A3 SLC22A12

3.79e-05182925bdeebbfffc1308a29b721a5f8fed23a28d7a2f2f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC13A3 SLC2A2 SLC22A12

3.79e-0518292557bb5a2da976464ba7c4460106bd9f692008ebd9
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC2A2

3.79e-051829259d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC13A3 SLC2A2 SLC22A12

3.89e-05183925facd6dbe0851b537d70a899ac7485714ab27d071
ToppCellCOVID-19-kidney-PCT-S1|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC22A12

3.89e-051839256878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC13A1 SLC17A1 SLC13A3 SLC2A2 SLC22A12

3.99e-051849253d7dd193a0826cc7a4e454a29236a16c315e5965
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC13A1 SLC17A1 SLC13A3 SLC2A2 SLC22A12

3.99e-0518492545577ff91c3b2b303acd97239dde2463ea7a429c
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC13A1 SLC17A1 SLC13A3 SLC2A2 SLC22A12

4.10e-051859253e3217c99719fd1d2fa94e16be7712a7e5077152
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC13A1 SLC17A1 SLC13A3 SLC2A2 SLC22A12

4.10e-051859250ff4148b4701003d9d594e0da8261176fb13aa59
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TACR2 GRIK1 TAFA5 ATP1B2 UNC79

4.21e-05186925d8d559daff4aeef334d403fde4e3ee2e4a6086d0
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRD LRRC3B RAPGEF4 UNC79 ITPR1

4.21e-05186925a1ab273b01971d6a892912560d387685dd657179
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC66A2 SLC17A1 SLC13A3 SLC2A2 SLC22A12

4.21e-051869255784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRD LRRC3B RAPGEF4 UNC79 ITPR1

4.31e-05187925ef3c85c01bc3da408ae288b6e3096ad888a12e63
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC13A3 SLC2A2 SLC22A12

4.31e-051879253ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCellCOVID-19-kidney-tDL|kidney / Disease (COVID-19 only), tissue and cell type

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC2A2

4.31e-05187925d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCellCOVID-19-kidney-Mito-rich_PCT|kidney / Disease (COVID-19 only), tissue and cell type

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC22A12

4.31e-05187925738ec2611b4be6a08eedad16b57fba84e1f11fef
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC22A12

4.42e-05188925f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC22A12

4.42e-051889250792432cd4c564dea1102241ea9884f7ced7658c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC22A12

4.54e-05189925204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRD LRRC3B RAPGEF4 UNC79 ITPR1

4.54e-051899253d838da870623a6a278ddc8e6cedca85d9877e50
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRD SLC24A3 ATP11C GRIK1 ATP1B2

4.54e-05189925979b7fa947538aa7ca4a219263da2575869a2caa
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC22A2 AR SLC2A2

4.54e-0518992528b502611829e4a24caff2562545c7db97686099
ToppCellpdx-Tumor_cells-T8|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

SLC45A3 SLC17A1 UROC1 SERINC5 SLC2A2

4.65e-05190925b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TACR2 GRIK1 TAFA5 ATP1B2 UNC79

4.65e-05190925ff3dec5b45c6ea9b5319fb51a0198c6773b7be26
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRRC3B SLC24A3 ATP11C GRIK1 ATP1B2

4.65e-05190925be2b184a3559da41ba387ae0fdbeb9ae532868a5
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TACR2 GRIK1 TAFA5 ATP1B2 UNC79

4.65e-051909254971857eac9af17d66d673ed2ab7072639f60a10
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC2A2

4.77e-051919253c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC2A2

4.77e-051919251c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRRC3B SLC24A3 ATP11C GRIK1 ATP1B2

4.89e-05192925342842378c20267c5044bdd622515e8b9f895623
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRD SLC24A3 ATP11C GRIK1 ATP1B2

4.89e-05192925bd3fa6c8fcb618db64d11f25cabaf08608957c35
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BRINP3 CLCN1 UGT3A1 OTOP2 CHRM3

5.26e-05195925e87b11e3242fdbed2e7f383e6876ec375af32bd4
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRD SLC24A3 ATP11C GRIK1 ATP1B2

5.26e-0519592598ca9f3aa36211dde1e6f7f3817b9418c95e583e
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NLGN3 NLGN4X ATP10B TACR3 TAFA5

5.39e-05196925f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NLGN3 NLGN4X ATP10B TACR3 TAFA5

5.39e-05196925671c380b58d7f634b4fbec38c357d357ea4f3535
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 UGT3A1 SLC13A3 SLC2A2 SLC22A12

5.52e-051979259b038dac4d4d306aa40ec07d79374c4fe9c604a6
ToppCellTracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

BRINP3 SRL TACR2 ATP1B2 ITPR1

5.66e-051989251e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 UGT3A1 SLC13A3 SLC2A2 SLC22A12

5.79e-051999254bde35e5df019189433d65d415e29a0c1145ac66
ToppCellCaecum-(5)_Dendritic_cell-(51)_cDC1|Caecum / shred on region, Cell_type, and subtype

CLCN1 GPER1 RAPGEF4 CATSPER3 AR

5.79e-051999252b97fda45241b2ce7be904cf081cabcf3eb5ba1d
ToppCellCaecum-Dendritic_cell-cDC1|Caecum / Region, Cell class and subclass

CLCN1 GPER1 RAPGEF4 CATSPER3 AR

5.79e-051999259ab38a0060a883de6fe3da8cdac42e124d7981d9
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

BRINP3 NLGN4X RAPGEF4 SLC24A3 GRIK1

5.93e-05200925f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

BRINP3 NLGN4X RAPGEF4 SLC24A3 GRIK1

5.93e-05200925cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC22A12

5.93e-05200925e118d5e6e5d5bb808877a6667668c36f21afad5b
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

BRINP3 NLGN4X RAPGEF4 SLC24A3 GRIK1

5.93e-05200925c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

BRINP3 NLGN4X RAPGEF4 SLC24A3 GRIK1

5.93e-052009254fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RARRES1 SLC13A1 SLC17A1 SLC22A2 AR

5.93e-05200925105564ee05bd11685b5747ee32d5350cf3c2e2e1
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 SLC17A1 SLC22A2 SLC13A3 SLC22A12

5.93e-05200925234e5a927eec0e235226586451ba3754c8a14169
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

BRINP3 NLGN4X RAPGEF4 SLC24A3 GRIK1

5.93e-05200925310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

BRINP3 NLGN4X RAPGEF4 SLC24A3 GRIK1

5.93e-05200925961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC13A1 UGT3A1 SLC13A3 SLC2A2 SLC22A12

5.93e-05200925825aad08431dd6b54aa636ace6efc821dfaf8014
ToppCellPosterior_cortex-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Tfr.Tmem2_(Tmem2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SLC45A3 HHAT ATP10B ACSS3

6.20e-05103924287e945ef2f9646f1ff4a4c50fe6e8a5e7fe0d92
ToppCell|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC45A3 SLC24A3 HACD4 CHRM3

1.16e-04121924da8fe561dcf50792d0cbcaad383d564f900a6677
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Proliferative_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GABRD TMC2 UGT3A1 ATP10B

1.48e-041299240dcce7cb95bb3593626ecb34ed9da58c7de4e016
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells-Mast-cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCC1 SLC13A1 SLC45A3 SLC24A3

1.67e-0413392481189e8516a431d5890a0909f9fc7c82ec3442bc
ToppCellLPS_only-Hematopoietic_Mast-Mast_cells-Mast-cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC45A3 SLC24A3 HACD4 CHRM3

1.82e-0413692482d7f90ef2a63a3137c331efd68c036cd0db3ac1
ToppCellLPS-IL1RA-Hematopoietic_Mast-Mast_cells-Mast-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCC1 SLC45A3 SLC24A3 CHRM3

1.97e-04139924f1d1a51a79afdddc82e73cd29b3240e3e973db28
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CDRT4 SLC26A8 BRINP3 NLGN4X

2.32e-04145924b961b69befb15ff6f58635e0d4bda88ea732a346
ToppCellPND03-Immune-Immune_Myeloid-Granulocytic-Mast|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RARRES1 PSEN2 SLC31A2 SLC45A3

2.71e-041519249702575e47ececcf0a9f0f20a4a920dbb1ba5657
ToppCellTCGA-Kidney|World / Sample_Type by Project: Shred V9

SLC13A1 SLC17A1 SLC22A2 SLC22A12

2.71e-04151924e31974c0d0a0c644205a0ee6013ab74a09d8a306
ToppCellPND03-Immune-Immune_Myeloid-Granulocytic-Mast-Mast_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RARRES1 PSEN2 SLC31A2 SLC45A3

2.71e-04151924673e4ab117b723c14d1df3804bbedc9e48284a9d
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC24A3 ATP11C GRIK1 TBC1D8B

2.78e-041529248ff5a178a8f3550d89a003c0858820aab3773386
ToppCellTCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

SLC13A1 SLC17A1 UGT3A1 SLC22A12

2.92e-0415492489a60a79d07466d7ad05888d10a72d3b1ab384af
ToppCellTCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal-Connective_tissue_normal|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

SLC13A1 SLC17A1 UGT3A1 SLC22A12

2.92e-04154924f1fea1a87e977221fa125b62287368be9af4987d
Drugmersalyl

SLC37A1 SLC16A1 SLC17A1 SLC13A3 AR ITPR1

1.17e-0685916CID000010294
Drug4-cpp

GMCL1 GMCL2 CLCN1

9.96e-0611913CID000018703
Drugezlopitant

TACR2 GRIK1 TACR3

9.96e-0611913CID000188927
DrugProtriptyline hydrochloride [1225-55-4]; Down 200; 13.4uM; MCF7; HT_HG-U133A

COL4A5 TRPM4 BRINP3 GPER1 TAF1 CHRM3 PIGO

1.38e-051969175438_DN
DrugS-182

PSEN1 PSEN2

1.58e-052912CID003033995
DiseaseAlzheimer's disease 3 (implicated_via_orthology)

PSEN1 PSEN2

9.41e-062912DOID:0110042 (implicated_via_orthology)
DiseaseColorectal Carcinoma

ABCC1 GMCL2 SLC66A2 NLGN4X ABCB10 LRRC3B FRMPD2 OTOP2 ATP11C PIGO

6.19e-057029110C0009402
DiseaseKohlschutter-Tonz syndrome (implicated_via_orthology)

SLC13A1 SLC13A3

9.35e-055912DOID:0111668 (implicated_via_orthology)
DiseaseX-12798 measurement

SLC17A1 SLC22A2

9.35e-055912EFO_0021335
Diseaseearly-onset Parkinson's disease (implicated_via_orthology)

PSEN1 PSEN2

1.40e-046912DOID:0060894 (implicated_via_orthology)
DiseaseAsphyxia Neonatorum

PSEN1 PSEN2

1.40e-046912C0004045
DiseaseHyperphosphatasia-intellectual disability syndrome

PGAP2 PIGO

1.40e-046912cv:C1855923
Diseaseepilepsy (implicated_via_orthology)

SLC13A1 SLC24A3 SLC13A3 ATP1B2 ATP1B3

1.53e-04163915DOID:1826 (implicated_via_orthology)
DiseaseEarly-onset autosomal dominant Alzheimer disease

PSEN1 PSEN2

1.96e-047912cv:CN043596
DiseaseHyperphosphatasia with Mental Retardation

PGAP2 PIGO

1.96e-047912C1855923
Diseasealcohol-related neurodevelopmental disorder (implicated_via_orthology)

SLC13A1 SLC13A3

2.60e-048912DOID:0050667 (implicated_via_orthology)
Diseasecardiac arrest (biomarker_via_orthology)

TRPM4 ITPR1

2.60e-048912DOID:0060319 (biomarker_via_orthology)
DiseaseAlzheimer disease

PSEN1 PSEN2

2.60e-048912cv:C0002395
Diseaseautistic disorder (is_implicated_in)

NLGN3 NLGN4X RAPGEF4

2.99e-0442913DOID:12849 (is_implicated_in)
Diseaseestradiol measurement

UGT3A1 ATP1B2 AR HELB

3.81e-04110914EFO_0004697
Diseasemyopathy (implicated_via_orthology)

COL4A5 CLCN1 HMGCR

4.44e-0448913DOID:423 (implicated_via_orthology)
Diseasepregnenediol disulfate (C21H34O8S2) measurement

SLC17A1 UGT3A1

5.08e-0411912EFO_0800279
Diseaseglucose-dependent insulinotropic peptide measurement

ABCB9 SLC13A3 GRIK1

5.95e-0453913EFO_0008464
Diseasepolyunsaturated fatty acid measurement

NAA25 AGO2 SLC22A2 HMGCR

7.36e-04131914EFO_0010733
Diseasehemoglobin A1 measurement

ABCC1 GMCL2 NAA25 ABCB10 SLC22A2 ATP1B2 SLC2A2

1.15e-03520917EFO_0007629
DiseaseHbA1c measurement

KLHL29 ABCC1 NAA25 PSEN1 SRL TACR2 ATP1B2 SLC2A2

1.15e-03675918EFO_0004541
DiseaseAlcoholic Intoxication, Chronic

AGO2 NLGN4X GRIK1 TACR3 AR

1.47e-03268915C0001973
DiseaseMalignant neoplasm of breast

OR12D3 ABCC1 NAA25 CLCN1 ABCB10 GPER1 LRRC3B SMARCAL1 AR SLC2A2

1.75e-0310749110C0006142
Diseasedilated cardiomyopathy (implicated_via_orthology)

PSEN1 PSEN2 DICER1

1.96e-0380913DOID:12930 (implicated_via_orthology)
Diseasemean corpuscular hemoglobin concentration

KLHL29 ABCC1 SLC26A8 AGO2 AGO4 UBR5 SLC31A2 STK17A PIGO DMXL1

2.15e-0311059110EFO_0004528
DiseaseRenal glomerular disease

COL4A5 SMARCAL1

2.28e-0323912C0268731
DiseaseGlomerulopathy Assessment

COL4A5 SMARCAL1

2.28e-0323912C4521256
Diseaseserum metabolite measurement

ABCC1 PSEN2 SLC17A1 PGAP2 HHAT SLC22A2 UGT3A1 SLC24A3 SLC13A3

2.56e-03945919EFO_0005653

Protein segments in the cluster

PeptideGeneStartEntry
PMNYFLNTSTIMHLW

BRINP3

331

Q76B58
MISTVTSNAFFMALW

CATSPER3

56

Q86XQ3
TYEKMWAFMSSRQQT

GRIK1

716

P39086
SMNLFTTYIIMNRWA

CHRM3

121

P20309
MTVGELSSFLMYAFW

ABCB10

426

Q9NRK6
WNMMLNIDVSATAFY

AGO4

201

Q9HCK5
MDSGMSLETVWQVYY

DICER1

1821

Q9UPY3
NSNSYSWSLMRLAMV

DMXL1

2481

Q9Y485
FSSSTMIDYWQMIFF

ATP10B

1136

O94823
WKMMLNIDVSATAFY

AGO2

211

Q9UKV8
YFSSMFSGSWKESSM

GMCL1

131

Q96IK5
LSSWIQMSFKHYAMQ

RCN2

86

Q14257
LNTKTSYTMLFDWMY

RANBP17

731

Q9H2T7
DTAWVSSIMLAMLYG

SLC16A8

56

O95907
ESTLSMWGAYSVLAM

CDRT4

96

Q8N9R6
SEVSWISSIMLAVMY

SLC16A1

56

P53985
YTVVLTNMAFHMTAW

PGAP2

221

Q9UHJ9
TSLWSELFNSMFMSF

MDN1

3006

Q9NU22
ELFNSMFMSFWSSTV

MDN1

3011

Q9NU22
IVTTWMFIRSYMSFS

FAM3D

16

Q96BQ1
MSFWSSISFNLAVLM

ITPR1

2281

Q14643
WNLLDMVRYTYSMLS

HACD4

121

Q5VWC8
SLWQFYLSKMISMDI

HMGCR

306

P04035
VFYGFLTAMFTLTMW

ATP1B2

46

P14415
SMSTLPSMLSIYWFN

OR51H1

76

Q8NH63
MITTAAEWSMSFSFF

DRAM2

206

Q6UX65
NKFSWMSYVSMIAIF

SLC2A2

391

P11168
ANMEYTMTVFLHQSW

GABRD

81

O14764
TTDYAMLVTMFGWFT

LRRC3B

201

Q96PB8
MVFAMGWRSFTNVNS

AR

746

P10275
YSAFVVWARSAMGMF

EXOC8

486

Q8IYI6
ASSTLWIAAFSYMMV

SLC24A3

481

Q9HC58
AWLISFFYALMHSVM

OR12D3

146

Q9UGF7
SLFASTMLYVMWKNV

OTOP2

251

Q7RTS6
AHSMALSMSGNIYSW

HERC5

201

Q9UII4
STMFSFTGMWRYFDV

HHAT

326

Q5VTY9
VMLSAVVMTYWTNFA

NLGN3

551

Q9NZ94
DVMLSAVVMTYWTNF

NLGN4Y

516

Q8NFZ3
LSPSGWSNVFYMLMF

SLC37A1

486

P57057
TTMEHLFWSFILYMT

ELOVL3

231

Q9HB03
ASQMHVYSLGMTLYW

FRMPD2

101

Q68DX3
MLAVMSYNTWIFLGV

SLC31A2

111

O15432
DSLWIGYSFMMHTSA

COL4A5

1591

P29400
SMWMARTSYLAAFAI

TMEM259

296

Q4ZIN3
LTWSYLQMAVMGTAA

SLC22A12

176

Q96S37
GFMSSTAFLSMWLSN

SLC13A1

126

Q9BZW2
SFLSMWLSNTASTAM

SLC13A3

136

Q8WWT9
KHTMILMYNWFTSSV

SLC22A2

346

O15244
DVMLSAVVMTYWTNF

NLGN4X

516

Q8N0W4
VNYSFYSWTQTMMTT

HELB

561

Q8NG08
ALFWLAMSSTMYNPI

TACR2

291

P21452
FSSLAGMMFEWSIAQ

NUP210L

161

Q5VU65
HMAANMYVLWSFSSS

PARL

221

Q9H300
TTYLNWLVRMSSEME

ABCC1

1241

P33527
LPSMSSTFWAFMILA

TAFA5

16

Q7Z5A7
MSSKDLAYQMTIYDW

RAPGEF4

771

Q8WZA2
LIYSSTMVWLVNMAE

PSEN1

286

P49768
WLPSSMTRNAMAYNV

TAF1

436

P21675
DCALWMMTFSSSIFL

SLC26A8

486

Q96RN1
VLMVNTGSWYTVSHM

NSUN7

296

Q8NE18
YFSSMFSGSWKESSM

GMCL2

131

Q8NEA9
MYSSVFFLTWMSFDR

GPER1

141

Q99527
WSHNIMTLYTPMFIN

SLC17A1

276

Q14916
TWNFSMNDYSALMKA

SMARCAL1

276

Q9NZC9
QVYLASFWLAMSSTM

TACR3

336

P29371
SFWLAMSSTMYNPII

TACR3

341

P29371
SWMALMTFTLFYTDF

SLC45A3

281

Q96JT2
VITVYTMYLTWSAMT

SERINC1

266

Q9NRX5
SMATDMWSIGVLTYV

STK17A

241

Q9UEE5
MARFSYSVIWIMAIS

TDGF1

6

P13385
MFSLSWQLSLVTFMG

ABCB9

321

Q9NP78
YAVMLHWSMSSIYGL

ACSS3

316

Q9H6R3
AALFSFTMWVMLQTL

ATP1B3

51

P54709
LLMALVSWSMDYVSA

CLCN1

126

P35523
MYFVFAQMLSSVSTW

ATP11C

1056

Q8NB49
MFFSFSRSQWDMQST

UGT3A1

206

Q6NUS8
MTDMTFFSSVSLSWF

TBC1D8B

636

Q0IIM8
AQFWLTMFYLSKMTE

UROC1

136

Q96N76
LSMWGMFSVITSYIL

RNF175

106

Q8N4F7
ATQMLMRVYGALFWS

SRL

261

Q86TD4
SLYVMMTVTNWFNHV

SERINC5

401

Q86VE9
ALIYSSAMVWTVGMA

PSEN2

291

P49810
SEVATAFAYLMTDMW

USP50

91

Q70EL3
TLYTMYLTWSAMSNE

SERINC3

276

Q13530
AVSAWALMATQTFYS

PIGO

891

Q8TEQ8
VMASTNSLMWTFFSR

TMEM42

76

Q69YG0
TSMYFQCWAVMSSNV

TMC2

666

Q8TDI7
WMTYTFSFFMFSSIM

XKRX

66

Q6PP77
FLGSSYVMWEMTTQV

RARRES1

196

P49788
MVLMWTSGDAFKTAY

SLC66A2

206

Q8N2U9
MYFWEMGSNAVSSAL

TRPM4

576

Q8TD43
MSMTERQDLVYFWTS

UBR5

2721

O95071
LVAMVFQWFHSTAYM

UNC79

526

Q9P2D8
YMSLLDNWNLVSRMT

KLHL29

656

Q96CT2
NPYYFWSVMSLIMQS

NAA25

146

Q14CX7