Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainSCAN

ZSCAN31 ZNF165 ZNF397 ZSCAN23 ZNF287

1.45e-0656655SM00431
DomainSCAN_BOX

ZSCAN31 ZNF165 ZNF397 ZSCAN23 ZNF287

1.73e-0658655PS50804
DomainSCAN

ZSCAN31 ZNF165 ZNF397 ZSCAN23 ZNF287

1.73e-0658655PF02023
DomainSCAN_dom

ZSCAN31 ZNF165 ZNF397 ZSCAN23 ZNF287

1.73e-0658655IPR003309
DomainRetrov_capsid_C

ZSCAN31 ZNF165 ZNF397 ZSCAN23 ZNF287

1.89e-0659655IPR008916
DomainZINC_FINGER_C2H2_1

TUT4 ZSCAN31 ZNF165 ZNF69 ZNF397 ZNF763 ZSCAN23 ZNF287 ZNF557

1.41e-03777659PS00028
Domainzf-C2H2

ZSCAN31 ZNF165 ZNF69 ZNF397 ZNF763 ZSCAN23 ZNF287 ZNF557

2.69e-03693658PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZSCAN31 ZNF165 ZNF69 ZNF397 ZNF763 ZSCAN23 ZNF287 ZNF557

2.72e-03694658IPR013087
DomainZINC_FINGER_C2H2_2

ZSCAN31 ZNF165 ZNF69 ZNF397 ZNF763 ZSCAN23 ZNF287 ZNF557

5.29e-03775658PS50157
DomainZnf_C2H2-like

ZSCAN31 ZNF165 ZNF69 ZNF397 ZNF763 ZSCAN23 ZNF287 ZNF557

6.20e-03796658IPR015880
DomainZnf_C2H2

ZSCAN31 ZNF165 ZNF69 ZNF397 ZNF763 ZSCAN23 ZNF287 ZNF557

6.62e-03805658IPR007087
DomainZnF_C2H2

ZSCAN31 ZNF165 ZNF69 ZNF397 ZNF763 ZSCAN23 ZNF287 ZNF557

6.76e-03808658SM00355
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

ITGA11 RINT1 LMAN1 BTD ASPH LAMB2 NGLY1 MMP2 HM13 M6PR SLC33A1 GNS SORL1

5.00e-071201681335696571
Pubmed

Investigating the Endo-Lysosomal System in Major Neurocognitive Disorders Due to Alzheimer's Disease, Frontotemporal Lobar Degeneration and Lewy Body Disease: Evidence for SORL1 as a Cross-Disease Gene.

DNAJC6 SORL1

3.77e-06268234948429
Pubmed

SH2-B family members differentially regulate JAK family tyrosine kinases.

JAK1 SH2B2

1.13e-05368211751854
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

LMAN1 STYX IFT172 ASPH LAMB2 NGLY1 DNAJC6 BAG6 PCM1 SORL1

1.89e-05974681028675297
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

PREB UBE4A RINT1 LMAN1 ASPH LAMB2 TTYH3 RERE HM13 M6PR BAG6

2.04e-051203681129180619
Pubmed

Genetic susceptibility to total hip arthroplasty failure: a preliminary study on the influence of matrix metalloproteinase 1, interleukin 6 polymorphisms and vitamin D receptor.

MMP2 VDR

2.25e-05468217363400
Pubmed

ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.

PREB RINT1 LMAN1 HM13 BAG6 SLC33A1

2.69e-0529968637931956
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

PREB UBE4A RINT1 LMAN1 ASPH PPA2 HM13 DNAJC6 M6PR BAG6 SLC33A1 PCM1

2.82e-051487681233957083
Pubmed

HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA.

M6PR SORL1

3.75e-05568230679749
Pubmed

Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.

JAK1 UBE4A TRMT2A ASPSCR1 NGLY1

4.87e-0520268529540532
Pubmed

Matrix metalloproteinase 2 and 9 dysfunction underlie vascular stiffness in circadian clock mutant mice.

PER3 MMP2

5.62e-05668220829506
Pubmed

CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement.

PREB FSIP2 IFT172 ASPH PPA2

6.26e-0521368529615496
Pubmed

Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.

RINT1 LMAN1 STYX PPA2 TTYH3 NGLY1 M6PR BAG6 PCM1

8.14e-0593168927432908
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

PREB UBE4A RINT1 TUT4 LMAN1 COX6B1 PPA2 RERE HM13 BAG6 SLC33A1

1.44e-041496681132877691
Pubmed

Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

CEP350 RERE DNAJC6

1.84e-04566839455484
Pubmed

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

JAK1 UBE4A TRMT2A HM13 BAG6

2.36e-0428368521903422
Pubmed

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.

JAK1 SH2B2

2.45e-041268210872802
Pubmed

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

PREB LMAN1 COX6B1 ASPH PPA2 TTYH3 M6PR BAG6

2.68e-0485968831536960
Pubmed

Global landscape of HIV-human protein complexes.

PREB LMAN1 COX6B1 NGLY1 HM13 BAG6

2.74e-0445768622190034
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

PREB PPP4R1 RINT1 TRMT2A ASPH SLC33A1 SORL1

2.79e-0465068738777146
Pubmed

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

PREB UBE4A RINT1 LMAN1 HM13 SLC33A1

3.11e-0446868631056421
Pubmed

Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.

JAK1 DNAJC6

3.38e-041468232123171
Pubmed

HIV-host interactome revealed directly from infected cells.

LMAN1 ASPH HM13 BAG6

3.68e-0417268427375898
Pubmed

Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.

PREB ASPH HM13 SLC33A1

3.84e-0417468432149426
Pubmed

Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.

KAT2B VDR

3.89e-04156829267036
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS20 C6 MMP2

4.36e-047568320637190
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

PREB RINT1 LMAN1 TENM1 BAG6 SLC33A1

4.60e-0450468634432599
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

KAT2B GNPDA2 PPA2 DNAJC6

4.94e-0418668433637726
Pubmed

Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.

NTF4 LAMB2 MMP2

5.47e-048168339217171
Pubmed

Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?

IFT172 RERE

5.65e-041868226921296
Pubmed

Agrin has a pathological role in the progression of oral cancer.

ASPH PPA2 M6PR GNS

6.13e-0419768429872149
Pubmed

Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.

UBE2Z UBE2W

6.30e-041968227425610
Pubmed

Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling.

LAMB2 MMP2

7.00e-042068221750040
Pubmed

Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes.

ZNF397 ZNF763

8.48e-04226821505991
Pubmed

Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.

ITGA11 TENM1

8.48e-042268235245678
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

PREB RINT1 LMAN1 HM13 SLC33A1 PCM1

8.59e-0456868637774976
Pubmed

APJ Regulates Parallel Alignment of Arteries and Veins in the Skin.

APLNR MMP2

9.28e-042368225920569
Pubmed

FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.

ASPH ASPSCR1 NGLY1 BAG6

9.88e-0422468428443643
Pubmed

Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.

UBE2Z UBE2W

1.10e-032568217597759
Pubmed

Wdnm1-like, a new adipokine with a role in MMP-2 activation.

MMP2 SH2B2

1.10e-032568218492766
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

TUT4 LAMB2 BAG6 PCM1

1.18e-0323568430258100
Pubmed

The DNA sequence and analysis of human chromosome 6.

GJE1 ZSCAN31 ZNF165 KDM1B ZSCAN23 BAG6

1.37e-0362268614574404
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

JAK1 KAT2B TUT4 TRMT2A RERE KDM1B PCM1 SORL1

1.47e-03111668831753913
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

CEP350 HM13 SH2B2 PCM1

1.50e-0325168429778605
Pubmed

A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.

UBE4A UBE2Z UBE2W

1.62e-0311868319690564
Pubmed

Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.

TENM1 SORL1

1.69e-033168227798109
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

JAK1 RINT1 LMAN1 TTYH3 HM13 BAG6

1.80e-0365768636180527
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

FSIP2 ATP13A5 CCDC168

1.83e-0312368326912792
Cytoband1p36.23

PER3 RERE

1.94e-04146821p36.23
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZSCAN31 ZNF165 ZNF69 ZNF397 ZNF763 ZSCAN23 ZNF287 ZNF557

7.29e-0471850828
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#1

JAK1 UBE4A RINT1 TUT4 GJE1 BTD IFT172 GAL3ST3 ADAMTS20 TTYH3 RERE

2.60e-057806611Facebase_RNAseq_e10.5_Lateral Nasal Eminence_2500_K1
ToppCellfacs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPGRIP1 ASPH LAMB2 SH2B2 SLC33A1 TMEM82

2.40e-07170686d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell367C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PPP4R1 AFAP1L2 ASPH GNS ZNF557

8.02e-061796855aa8465e943b6b666c7f8b1937fcc3764bfe91f6
ToppCellB_cells-Plasma_cells_and_plasmablasts|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

PREB LMAN1 HM13 SLC33A1 VDR

1.27e-051976853b1c574b3d119b63967bb1306f0353ecc4c522f3
Diseasemyopia (is_implicated_in)

MMP2 VDR

6.15e-0416682DOID:11830 (is_implicated_in)
Diseaseproteinuria (implicated_via_orthology)

LAMB2 C6

2.18e-0330682DOID:576 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
TYSDFCQFRPPVRVN

VDR

146

P11473
ESADFCNKYLRFQPQ

SLC33A1

236

O00400
RRQDFNPCEYDLKFQ

ASPSCR1

41

Q9BZE9
ARFCRSETVPKNFPQ

ATP13A5

631

Q4VNC0
SALPPQRQDRFYSNC

CTAGE1

586

Q96RT6
YSPQRFPNAQRAFAD

BAG6

1116

P46379
NQYTPDAQRFNCQKP

AFAP1L2

281

Q8N4X5
TRPFCFFSKYVDNPQ

ACSM4

426

P0C7M7
YPQSPRARYGKAQCE

ASPH

371

Q12797
RLKNPYQCPFNGSRR

ADAMTS20

1771

P59510
RCGNPDVANYNFFPR

MMP2

101

P08253
PLRQYFFETRCKADN

NTF4

131

P34130
RCMNYDPNQRPFFRA

JAK1

826

P23458
NSCLNPFLYAFFDPR

APLNR

301

P35414
CQFSNRFPRYNNPEK

NGLY1

286

Q96IV0
DLQRVFTNCKEYNPP

KAT2B

791

Q92831
PPLENCESRFYNHFK

FSIP2

2886

Q5CZC0
NCPFSADENYRPLAK

PCM1

956

Q15154
QRAARYECAPVKPFF

PER3

196

P56645
ALASCQRDFRNKPYP

LMAN1

186

P49257
RCEQVQPGYFRPFLD

LAMB2

551

P55268
NKFFPASFPNRQYQL

HM13

126

Q8TCT9
RRLQKQVCNVSYPFF

ITGA11

886

Q9UKX5
APANPQNFNIYKRIF

IFT172

1471

Q9UG01
NAINKNFYRKFCPPS

OR10H4

301

Q8NGA5
QPQRRFTPAVCFYQP

PRTG

1066

Q2VWP7
NQYCPAFRRVPNASL

GAL3ST3

166

Q96A11
NRYFQPFYQPNECGK

KDM1B

266

Q8NB78
YKRSRTRECNNPAPQ

C6

581

P13671
RRDYCNFFQKPVPRT

BTBD8

301

Q5XKL5
IPFFNKQRNGCRPYC

DNAJC6

241

O75061
PCRINSSYFRRVKNP

CEP350

3001

Q5VT06
DKREVNLFCYNQFRP

GJE1

56

A6NN92
NLFCYNQFRPITPQV

GJE1

61

A6NN92
SSDPRCPKDGRYQFN

BTD

181

P43251
CNRIIQFKPGQDRYF

GNPDA2

21

Q8TDQ7
APQYQKAFQNVFAPR

GNS

241

P15586
IPKPTCRFKDAFQQY

DDX53

216

Q86TM3
YSERKQNRPFFFACV

CCDC168

7006

Q8NDH2
NYKTAPFDSRFPNQN

COX6B1

11

P14854
NPTEAPNCSRYFQFR

SORL1

1361

Q92673
RPSPQQTEYRNKCEF

TRMT2A

231

Q8IZ69
ASNNPYFRDQARFPV

RPGRIP1

841

Q96KN7
FCQENRPSIPYAFSK

PPP4R1

116

Q8TF05
KVYLQQRRCPNAFVF

TMEM229A

106

B2RXF0
QRRCPNAFVFNFLLY

TMEM229A

111

B2RXF0
SRPAFTFNKPYRCCN

TENM1

301

Q9UKZ4
RRPNTPYFICSIQDF

RERE

116

Q9P2R6
GQPCSQNYRLFFKNV

PPA2

41

Q9H2U2
ELFIQQCPFFFYNRP

ARHGAP35

1426

Q9NRY4
AFAYVQERRFCINPN

STYX

146

Q8WUJ0
RYQACRFGQVPDQPA

PREB

246

Q9HCU5
LFRQFCYQETPGPRE

ZSCAN31

41

Q96LW9
ETCRQNFRNFPYPDL

ZNF287

46

Q9HBT7
DFVCRSKPRNVPAAY

M6PR

241

P20645
NLFPLFSHYCKRPEN

RINT1

711

Q6NUQ1
KFCRFLRDNPAYDTP

SH2B2

41

O14492
VYFFVGCANDPQRRP

TMEM82

46

A0PJX8
CRFCFPYKSFRRNPQ

TRIM60

56

Q495X7
RFNPNFYRNGKVCLS

UBE2Z

176

Q9H832
QQFRKFCYQETPGPR

ZNF397

51

Q8NF99
CQQPKKAFRYHPSFR

ZNF69

166

Q9UC07
LFRQFCYQDSPGPRE

ZNF165

51

P49910
PDNSFYVRTCNKNPK

UBE2W

126

Q96B02
KRVFCNFQYAPQLAE

UBE4A

706

Q14139
CQQPKKAFRYHPSFR

ZNF763

146

Q0D2J5
PYKCNQCFREFRTQS

ZNF557

256

Q8N988
ARFQPNKPFYTQDRC

TUT4

1611

Q5TAX3
YLACSPRAANPFQQK

TTYH3

296

Q9C0H2
FRQFCYQESPGPREA

ZSCAN23

51

Q3MJ62