Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

VLDLR LRP1 LRP2 LRP1B

1.92e-0716664GO:0005041
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

VLDLR LRP1 LRP2 LRP1B

6.24e-0721664GO:0030228
GeneOntologyMolecularFunctioncalcium ion binding

VLDLR NELL2 EYS FBN2 PCDH11Y SLIT3 LRP1 LRP2 ADGRE2 LRP1B NOTCH1 PCDH17 NOTCH2

8.55e-077496613GO:0005509
GeneOntologyMolecularFunctioncargo receptor activity

VLDLR LRP1 LRP2 LRP1B

1.80e-0485664GO:0038024
GeneOntologyBiologicalProcesscardiac septum development

TGFBR2 NPHP3 WNT11 SLIT3 LRP1 LRP2 NOTCH1 NOTCH2

9.50e-09134658GO:0003279
GeneOntologyBiologicalProcesscardiac chamber development

TGFBR2 NPHP3 WNT11 SLIT3 LRP1 LRP2 NOTCH1 NOTCH2 ADGRG6

2.10e-08212659GO:0003205
GeneOntologyBiologicalProcesscardiac septum morphogenesis

TGFBR2 WNT11 SLIT3 LRP2 NOTCH1 NOTCH2

3.66e-0789656GO:0060411
GeneOntologyBiologicalProcesscardiac chamber morphogenesis

TGFBR2 WNT11 SLIT3 LRP2 NOTCH1 NOTCH2 ADGRG6

7.38e-07161657GO:0003206
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

TGFBR2 MTMR4 FBN2 WFIKKN1 LRP1 LRP2 SMPD3 ITGB8 NOTCH1 NOTCH2

1.22e-064456510GO:0141091
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

TGFBR2 MTMR4 FBN2 WFIKKN1 LRP1 LRP2 SMPD3 ITGB8 NOTCH1 NOTCH2

2.51e-064826510GO:0007178
GeneOntologyBiologicalProcessaxon guidance

NELL2 SLIT3 LRP1 LRP2 SEMA4A NOTCH1 NOTCH2 USP33

3.07e-06285658GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

NELL2 SLIT3 LRP1 LRP2 SEMA4A NOTCH1 NOTCH2 USP33

3.15e-06286658GO:0097485
GeneOntologyBiologicalProcessgrowth

DCAF1 TGFBR2 NELL2 EYS SORBS2 WNT11 SLIT3 LRP1 TMPRSS4 MINAR1 SMPD3 ATP1A3 VPS13B NOTCH1 NOTCH2

5.10e-0612356515GO:0040007
GeneOntologyBiologicalProcesscirculatory system development

TGFBR2 TMEM67 FLT1 SORBS2 NPHP3 WNT11 SLIT3 LRP1 LRP2 LRP5 MINAR1 SEMA4A ITGB8 NOTCH1 NOTCH2 ADGRG6

7.34e-0614426516GO:0072359
GeneOntologyBiologicalProcessheart morphogenesis

TGFBR2 NPHP3 WNT11 SLIT3 LRP2 NOTCH1 NOTCH2 ADGRG6

7.36e-06321658GO:0003007
GeneOntologyBiologicalProcesscardiac atrium development

NPHP3 WNT11 NOTCH1 NOTCH2

9.19e-0642654GO:0003230
GeneOntologyBiologicalProcessventricular septum development

TGFBR2 WNT11 SLIT3 LRP2 NOTCH1

1.00e-0591655GO:0003281
GeneOntologyBiologicalProcessartery morphogenesis

TGFBR2 WNT11 LRP1 LRP2 NOTCH1

1.06e-0592655GO:0048844
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

TGFBR2 MTMR4 FBN2 WFIKKN1 LRP1 LRP2 NOTCH1 NOTCH2

1.30e-05347658GO:0090092
GeneOntologyBiologicalProcessregionalization

TGFBR2 TMEM67 NPHP3 WNT11 ETS2 LRP2 LRP5 NOTCH1 NOTCH2

1.81e-05478659GO:0003002
GeneOntologyBiologicalProcesssemi-lunar valve development

TGFBR2 SLIT3 NOTCH1 NOTCH2

1.85e-0550654GO:1905314
GeneOntologyBiologicalProcessheart development

TGFBR2 TMEM67 SORBS2 NPHP3 WNT11 SLIT3 LRP1 LRP2 NOTCH1 NOTCH2 ADGRG6

2.22e-057576511GO:0007507
GeneOntologyBiologicalProcesstube development

TGFBR2 TMEM67 FLT1 NPHP3 WNT11 LRP1 LRP2 LRP5 MINAR1 SMPD3 SEMA4A EPCAM ITGB8 NOTCH1 NOTCH2

2.32e-0514026515GO:0035295
GeneOntologyBiologicalProcessventricular septum morphogenesis

TGFBR2 WNT11 SLIT3 NOTCH1

2.92e-0556654GO:0060412
GeneOntologyBiologicalProcesscellular response to tumor cell

NOTCH1 NOTCH2

2.93e-053652GO:0071228
GeneOntologyBiologicalProcesspattern specification process

TGFBR2 TMEM67 NPHP3 WNT11 ETS2 LRP2 LRP5 NOTCH1 NOTCH2

3.83e-05526659GO:0007389
GeneOntologyBiologicalProcesstube morphogenesis

TGFBR2 TMEM67 FLT1 NPHP3 WNT11 LRP1 LRP2 LRP5 MINAR1 SEMA4A ITGB8 NOTCH1 NOTCH2

4.09e-0511256513GO:0035239
GeneOntologyBiologicalProcessblood vessel morphogenesis

TGFBR2 FLT1 WNT11 LRP1 LRP2 LRP5 MINAR1 SEMA4A ITGB8 NOTCH1 NOTCH2

4.46e-058176511GO:0048514
GeneOntologyBiologicalProcessheart valve morphogenesis

TGFBR2 SLIT3 NOTCH1 NOTCH2

4.65e-0563654GO:0003179
GeneOntologyBiologicalProcessepithelial tube morphogenesis

TGFBR2 TMEM67 FLT1 NPHP3 LRP2 LRP5 NOTCH1 NOTCH2

5.14e-05421658GO:0060562
GeneOntologyBiologicalProcessLangerhans cell differentiation

TGFBR2 ITGB8

5.84e-054652GO:0061520
GeneOntologyBiologicalProcessartery development

TGFBR2 WNT11 LRP1 LRP2 NOTCH1

6.26e-05133655GO:0060840
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

TGFBR2 FLT1 MTMR4 FBN2 WFIKKN1 LRP1 LRP2 SMPD3 ITGB8 NOTCH1 NOTCH2

6.37e-058506511GO:0071363
GeneOntologyBiologicalProcessnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

MTMR4 FBN2 WFIKKN1 LRP1 LRP2 NOTCH1

6.39e-05218656GO:0090101
GeneOntologyBiologicalProcessatrial septum development

NPHP3 WNT11 NOTCH2

6.54e-0525653GO:0003283
GeneOntologyBiologicalProcessembryonic morphogenesis

TGFBR2 FLT1 NPHP3 FBN2 WNT11 ETS2 LRP2 LRP5 NOTCH1 NOTCH2

7.34e-057136510GO:0048598
GeneOntologyBiologicalProcesssecondary palate development

TGFBR2 WNT11 ITGB8

8.28e-0527653GO:0062009
GeneOntologyBiologicalProcessheart looping

TGFBR2 NPHP3 NOTCH1 NOTCH2

8.30e-0573654GO:0001947
GeneOntologyBiologicalProcessresponse to growth factor

TGFBR2 FLT1 MTMR4 FBN2 WFIKKN1 LRP1 LRP2 SMPD3 ITGB8 NOTCH1 NOTCH2

8.96e-058836511GO:0070848
GeneOntologyBiologicalProcessatrioventricular valve morphogenesis

TGFBR2 SLIT3 NOTCH1

9.25e-0528653GO:0003181
GeneOntologyBiologicalProcessmyeloid dendritic cell differentiation

TGFBR2 ITGB8 NOTCH2

9.25e-0528653GO:0043011
GeneOntologyBiologicalProcesspositive regulation of lysosomal protein catabolic process

LRP1 LRP2

9.72e-055652GO:1905167
GeneOntologyBiologicalProcesschemoattraction of axon

LRP1 LRP2

9.72e-055652GO:0061642
GeneOntologyBiologicalProcessconnective tissue development

TGFBR2 WNT11 LRP5 SMPD3 ITGB8 VPS13B NOTCH1

1.01e-04343657GO:0061448
GeneOntologyBiologicalProcessheart valve development

TGFBR2 SLIT3 NOTCH1 NOTCH2

1.08e-0478654GO:0003170
GeneOntologyBiologicalProcessanimal organ formation

TGFBR2 WNT11 LRP2 NOTCH1

1.08e-0478654GO:0048645
GeneOntologyBiologicalProcessdetermination of heart left/right asymmetry

TGFBR2 NPHP3 NOTCH1 NOTCH2

1.13e-0479654GO:0061371
GeneOntologyBiologicalProcessdevelopmental growth

TGFBR2 EYS SORBS2 WNT11 SLIT3 LRP1 SMPD3 ATP1A3 VPS13B NOTCH1 NOTCH2

1.18e-049116511GO:0048589
GeneOntologyBiologicalProcessembryonic heart tube morphogenesis

TGFBR2 NPHP3 NOTCH1 NOTCH2

1.19e-0480654GO:0003143
GeneOntologyBiologicalProcessaorta development

TGFBR2 LRP1 LRP2 NOTCH1

1.19e-0480654GO:0035904
GeneOntologyBiologicalProcessdetermination of left/right symmetry

TGFBR2 TMEM67 NPHP3 NOTCH1 NOTCH2

1.25e-04154655GO:0007368
GeneOntologyBiologicalProcessskeletal system development

TGFBR2 FBN2 WFIKKN1 WNT11 ETS2 LRP5 SMPD3 ITGB8 NOTCH2

1.27e-04615659GO:0001501
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

TGFBR2 TMEM67 FLT1 NPHP3 WNT11 LRP2 LRP5 NOTCH1 NOTCH2

1.33e-04619659GO:0002009
GeneOntologyBiologicalProcessatrioventricular valve development

TGFBR2 SLIT3 NOTCH1

1.39e-0432653GO:0003171
GeneOntologyBiologicalProcessanimal organ morphogenesis

TGFBR2 TMEM67 FLT1 NPHP3 FBN2 WNT11 SLIT3 LRP2 LRP5 SMPD3 NOTCH1 NOTCH2 ADGRG6

1.39e-0412696513GO:0009887
GeneOntologyBiologicalProcessblood vessel development

TGFBR2 FLT1 WNT11 LRP1 LRP2 LRP5 MINAR1 SEMA4A ITGB8 NOTCH1 NOTCH2

1.40e-049296511GO:0001568
GeneOntologyBiologicalProcessneuron development

TMEM67 VLDLR NELL2 RP1L1 SLIT3 LRP1 LRP2 MINAR1 SEMA4A TDP2 VPS13B NOTCH1 NOTCH2 USP33

1.52e-0414636514GO:0048666
GeneOntologyBiologicalProcesscardiac ventricle development

TGFBR2 WNT11 SLIT3 LRP2 NOTCH1

1.54e-04161655GO:0003231
GeneOntologyBiologicalProcessleft/right pattern formation

TGFBR2 TMEM67 NPHP3 NOTCH1 NOTCH2

1.59e-04162655GO:0060972
GeneOntologyBiologicalProcesskidney development

TMEM67 NPHP3 WNT11 LRP2 EPCAM NOTCH1 NOTCH2

1.66e-04372657GO:0001822
GeneOntologyBiologicalProcessdetermination of bilateral symmetry

TGFBR2 TMEM67 NPHP3 NOTCH1 NOTCH2

1.73e-04165655GO:0009855
GeneOntologyBiologicalProcessspecification of symmetry

TGFBR2 TMEM67 NPHP3 NOTCH1 NOTCH2

1.73e-04165655GO:0009799
GeneOntologyBiologicalProcessanatomical structure formation involved in morphogenesis

TGFBR2 FLT1 FBN2 WNT11 ETS2 LRP2 MINAR1 SMPD3 SEMA4A ITGB8 VPS13B NOTCH1 NOTCH2 ADGRG6

1.75e-0414836514GO:0048646
GeneOntologyBiologicalProcessheart formation

WNT11 LRP2 NOTCH1

1.98e-0436653GO:0060914
GeneOntologyBiologicalProcessvasculature development

TGFBR2 FLT1 WNT11 LRP1 LRP2 LRP5 MINAR1 SEMA4A ITGB8 NOTCH1 NOTCH2

2.03e-049696511GO:0001944
GeneOntologyBiologicalProcesspositive regulation of protein catabolic process in the vacuole

LRP1 LRP2

2.03e-047652GO:1904352
GeneOntologyBiologicalProcessrenal system development

TMEM67 NPHP3 WNT11 LRP2 EPCAM NOTCH1 NOTCH2

2.08e-04386657GO:0072001
GeneOntologyBiologicalProcessoutflow tract morphogenesis

TGFBR2 WNT11 LRP2 NOTCH1

2.21e-0494654GO:0003151
GeneOntologyBiologicalProcesstransforming growth factor beta receptor signaling pathway

TGFBR2 MTMR4 FBN2 WFIKKN1 LRP1 ITGB8

2.32e-04276656GO:0007179
GeneOntologyBiologicalProcessaortic valve morphogenesis

TGFBR2 SLIT3 NOTCH1

2.52e-0439653GO:0003180
GeneOntologyBiologicalProcessaorta morphogenesis

TGFBR2 LRP1 NOTCH1

2.92e-0441653GO:0035909
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

TGFBR2 FLT1 MTMR4 FBN2 WFIKKN1 LRP1 LRP2 SMPD3 ATP1A3 ITGB8 NOTCH1 NOTCH2

2.93e-0411866512GO:0007167
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

MTMR4 FBN2 WFIKKN1 LRP1 LRP2 NOTCH1 NOTCH2

3.10e-04412657GO:0090287
GeneOntologyBiologicalProcessembryonic heart tube development

TGFBR2 NPHP3 NOTCH1 NOTCH2

3.14e-04103654GO:0035050
GeneOntologyBiologicalProcessroof of mouth development

TGFBR2 WFIKKN1 WNT11 ITGB8

3.26e-04104654GO:0060021
GeneOntologyBiologicalProcesspositive regulation of nervous system development

FLT1 LRP1 LRP2 SEMA4A ADGRE2 NOTCH1 NOTCH2

3.38e-04418657GO:0051962
GeneOntologyBiologicalProcessatrioventricular node development

NOTCH1 NOTCH2

3.47e-049652GO:0003162
GeneOntologyBiologicalProcesspositive regulation of cardiac epithelial to mesenchymal transition

TGFBR2 NOTCH1

3.47e-049652GO:0062043
GeneOntologyBiologicalProcesscell adhesion involved in heart morphogenesis

TGFBR2 NOTCH1

3.47e-049652GO:0061343
GeneOntologyBiologicalProcessregulation of mesenchymal cell proliferation

TGFBR2 WNT11 LRP5

3.86e-0445653GO:0010464
GeneOntologyBiologicalProcessaxonogenesis

NELL2 SLIT3 LRP1 LRP2 SEMA4A NOTCH1 NOTCH2 USP33

3.90e-04566658GO:0007409
GeneOntologyBiologicalProcessBMP signaling pathway

MTMR4 LRP2 SMPD3 NOTCH1 NOTCH2

3.92e-04197655GO:0030509
GeneOntologyBiologicalProcessbranching morphogenesis of an epithelial tube

TGFBR2 TMEM67 FLT1 LRP5 NOTCH1

4.01e-04198655GO:0048754
GeneOntologyBiologicalProcessaortic valve development

TGFBR2 SLIT3 NOTCH1

4.12e-0446653GO:0003176
GeneOntologyBiologicalProcessmyeloid dendritic cell activation

TGFBR2 ITGB8 NOTCH2

4.12e-0446653GO:0001773
GeneOntologyBiologicalProcessgliogenesis

FLT1 LRP1 LRP2 ADAM22 NOTCH1 NOTCH2 ADGRG6

4.29e-04435657GO:0042063
GeneOntologyBiologicalProcesscoronary artery morphogenesis

LRP2 NOTCH1

4.33e-0410652GO:0060982
GeneOntologyBiologicalProcessnegative regulation of cell-cell adhesion mediated by cadherin

EPCAM NOTCH1

4.33e-0410652GO:2000048
GeneOntologyBiologicalProcesssecondary heart field specification

WNT11 LRP2

5.28e-0411652GO:0003139
GeneOntologyBiologicalProcessconvergent extension involved in gastrulation

NPHP3 WNT11

5.28e-0411652GO:0060027
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

VLDLR NELL2 SLIT3 LRP1 LRP2 SEMA4A NOTCH1 NOTCH2 USP33

5.37e-04748659GO:0048667
GeneOntologyBiologicalProcessregulation of stem cell proliferation

TGFBR2 WNT11 EPCAM NOTCH1

5.44e-04119654GO:0072091
GeneOntologyBiologicalProcesstissue morphogenesis

TGFBR2 TMEM67 FLT1 NPHP3 WNT11 LRP2 LRP5 NOTCH1 NOTCH2

5.47e-04750659GO:0048729
GeneOntologyBiologicalProcessgastrulation

TGFBR2 NPHP3 WNT11 ETS2 LRP5

5.48e-04212655GO:0007369
GeneOntologyBiologicalProcessresponse to BMP

MTMR4 LRP2 SMPD3 NOTCH1 NOTCH2

5.84e-04215655GO:0071772
GeneOntologyBiologicalProcesscellular response to BMP stimulus

MTMR4 LRP2 SMPD3 NOTCH1 NOTCH2

5.84e-04215655GO:0071773
GeneOntologyBiologicalProcessregulation of lysosomal protein catabolic process

LRP1 LRP2

6.32e-0412652GO:1905165
GeneOntologyBiologicalProcesscellular response to transforming growth factor beta stimulus

TGFBR2 MTMR4 FBN2 WFIKKN1 LRP1 ITGB8

6.58e-04336656GO:0071560
GeneOntologyBiologicalProcessdendritic cell differentiation

TGFBR2 ITGB8 NOTCH2

6.61e-0454653GO:0097028
GeneOntologyBiologicalProcessreceptor-mediated endocytosis

TGFBR2 VLDLR LRP1 LRP2 LDLRAD3 LRP1B

6.68e-04337656GO:0006898
GeneOntologyBiologicalProcessregulation of growth

DCAF1 TGFBR2 NELL2 WNT11 SLIT3 LRP1 TMPRSS4 MINAR1 NOTCH1

7.05e-04777659GO:0040008
GeneOntologyBiologicalProcessresponse to transforming growth factor beta

TGFBR2 MTMR4 FBN2 WFIKKN1 LRP1 ITGB8

7.33e-04343656GO:0071559
GeneOntologyBiologicalProcesschondrocyte development involved in endochondral bone morphogenesis

TGFBR2 SMPD3

7.46e-0413652GO:0003433
GeneOntologyBiologicalProcesstrabecula morphogenesis

FBN2 NOTCH1 ADGRG6

7.74e-0457653GO:0061383
GeneOntologyCellularComponentreceptor complex

TGFBR2 VLDLR FLT1 LRP1 LRP2 LRP5 LRP1B ITGB8 NOTCH1 NOTCH2

1.15e-055816510GO:0043235
GeneOntologyCellularComponentcell surface

TGFBR2 VLDLR LRP1 LRP2 ATP1A3 ADGRE2 EPCAM ITGB8 NOTCH1 NOTCH2 TSPAN33 ADGRG6

1.41e-0411116512GO:0009986
DomainEGF_1

VLDLR NELL2 EYS FBN2 MALRD1 SLIT3 LRP1 LRP2 LRP5 ADGRE2 LRP1B SSPOP ITGB8 ADAM22 NOTCH1 NOTCH2

4.23e-162556616PS00022
DomainEGF_2

VLDLR NELL2 EYS FBN2 MALRD1 SLIT3 LRP1 LRP2 LRP5 ADGRE2 LRP1B SSPOP ITGB8 ADAM22 NOTCH1 NOTCH2

7.78e-162656616PS01186
DomainEGF_CA

VLDLR NELL2 EYS FBN2 SLIT3 LRP1 LRP2 LRP5 ADGRE2 LRP1B NOTCH1 NOTCH2

9.62e-16996612PS01187
DomainEGF_3

VLDLR NELL2 EYS FBN2 MALRD1 SLIT3 LRP1 LRP2 LRP5 ADGRE2 LRP1B SSPOP ADAM22 NOTCH1 NOTCH2

3.04e-152356615PS50026
DomainEGF

VLDLR NELL2 EYS FBN2 MALRD1 SLIT3 LRP1 LRP2 LRP5 ADGRE2 LRP1B ITGB8 ADAM22 NOTCH1 NOTCH2

3.04e-152356615SM00181
DomainEGF-like_CS

VLDLR NELL2 EYS FBN2 MALRD1 SLIT3 LRP1 LRP2 LRP5 ADGRE2 LRP1B ITGB8 ADAM22 NOTCH1 NOTCH2

1.44e-142616615IPR013032
DomainEGF-like_Ca-bd_dom

VLDLR NELL2 EYS FBN2 SLIT3 LRP1 LRP2 LRP5 ADGRE2 LRP1B NOTCH1 NOTCH2

1.55e-141246612IPR001881
DomainEGF_Ca-bd_CS

VLDLR NELL2 EYS FBN2 SLIT3 LRP1 LRP2 ADGRE2 LRP1B NOTCH1 NOTCH2

3.51e-14976611IPR018097
DomainLdl_recept_a

VLDLR MALRD1 LRP1 LRP2 LRP5 TMPRSS4 LDLRAD3 LRP1B SSPOP

3.91e-1445669PF00057
Domain-

VLDLR MALRD1 LRP1 LRP2 LRP5 TMPRSS4 LDLRAD3 LRP1B SSPOP

4.84e-14466694.10.400.10
DomainLDLRA_1

VLDLR MALRD1 LRP1 LRP2 LRP5 TMPRSS4 LDLRAD3 LRP1B SSPOP

7.33e-1448669PS01209
DomainLDLRA_2

VLDLR MALRD1 LRP1 LRP2 LRP5 TMPRSS4 LDLRAD3 LRP1B SSPOP

8.96e-1449669PS50068
DomainLDrepeatLR_classA_rpt

VLDLR MALRD1 LRP1 LRP2 LRP5 TMPRSS4 LDLRAD3 LRP1B SSPOP

8.96e-1449669IPR002172
DomainLDLa

VLDLR MALRD1 LRP1 LRP2 LRP5 TMPRSS4 LDLRAD3 LRP1B SSPOP

8.96e-1449669SM00192
DomainEGF-type_Asp/Asn_hydroxyl_site

VLDLR NELL2 EYS FBN2 SLIT3 LRP1 LRP2 ADGRE2 LRP1B NOTCH1 NOTCH2

9.58e-141066611IPR000152
DomainEGF-like_dom

VLDLR NELL2 EYS FBN2 MALRD1 SLIT3 LRP1 LRP2 LRP5 ADGRE2 LRP1B ADAM22 NOTCH1 NOTCH2

1.62e-132496614IPR000742
DomainGrowth_fac_rcpt_

TMEM67 VLDLR NELL2 EYS FBN2 SLIT3 LRP1 LRP2 ADGRE2 LRP1B NOTCH1 NOTCH2

2.51e-131566612IPR009030
DomainEGF_CA

VLDLR NELL2 EYS FBN2 SLIT3 LRP1 LRP2 ADGRE2 LRP1B NOTCH1 NOTCH2

4.63e-131226611SM00179
DomainLDLR_class-A_CS

VLDLR MALRD1 LRP1 LRP2 LRP5 LDLRAD3 LRP1B SSPOP

1.10e-1240668IPR023415
DomainASX_HYDROXYL

VLDLR NELL2 EYS FBN2 LRP1 LRP2 ADGRE2 LRP1B NOTCH1 NOTCH2

2.01e-121006610PS00010
DomainEGF_CA

VLDLR NELL2 FBN2 LRP1 LRP2 ADGRE2 LRP1B NOTCH1 NOTCH2

1.81e-1186669PF07645
DomainEGF

VLDLR EYS MALRD1 SLIT3 LRP1 LRP2 LRP5 LRP1B NOTCH1 NOTCH2

2.08e-111266610PF00008
DomainLdl_recept_b

VLDLR LRP1 LRP2 LRP5 LRP1B

9.22e-1014665PF00058
DomainLDLRB

VLDLR LRP1 LRP2 LRP5 LRP1B

9.22e-1014665PS51120
DomainLY

VLDLR LRP1 LRP2 LRP5 LRP1B

1.38e-0915665SM00135
DomainLDLR_classB_rpt

VLDLR LRP1 LRP2 LRP5 LRP1B

1.38e-0915665IPR000033
DomainEGF_extracell

NELL2 LRP2 LRP1B ITGB8 ADAM22 NOTCH1

6.65e-0860666IPR013111
DomainEGF_2

NELL2 LRP2 LRP1B ITGB8 ADAM22 NOTCH1

6.65e-0860666PF07974
Domain-

VLDLR LRP1 LRP2 LRP5 LRP1B

2.48e-07396652.120.10.30
Domain6-blade_b-propeller_TolB-like

VLDLR LRP1 LRP2 LRP5 LRP1B

5.79e-0746665IPR011042
DomaincEGF

FBN2 LRP1 LRP2 LRP1B

2.01e-0626664IPR026823
DomaincEGF

FBN2 LRP1 LRP2 LRP1B

2.01e-0626664PF12662
DomainhEGF

EYS FBN2 NOTCH1 NOTCH2

2.73e-0628664PF12661
DomainDUF5050

LRP1 LRP1B

1.23e-052662IPR032485
DomainDUF5050

LRP1 LRP1B

1.23e-052662PF16472
DomainDUF3454

NOTCH1 NOTCH2

3.68e-053662PF11936
DomainDUF3454_notch

NOTCH1 NOTCH2

3.68e-053662IPR024600
DomainDUF3454

NOTCH1 NOTCH2

3.68e-053662SM01334
DomainNotch

NOTCH1 NOTCH2

7.35e-054662IPR008297
DomainNODP

NOTCH1 NOTCH2

7.35e-054662PF07684
DomainNotch_NODP_dom

NOTCH1 NOTCH2

7.35e-054662IPR011656
DomainNotch_NOD_dom

NOTCH1 NOTCH2

7.35e-054662IPR010660
DomainNOD

NOTCH1 NOTCH2

7.35e-054662PF06816
DomainNOD

NOTCH1 NOTCH2

7.35e-054662SM01338
DomainNODP

NOTCH1 NOTCH2

7.35e-054662SM01339
DomainLNR

NOTCH1 NOTCH2

1.22e-045662PS50258
DomainConA-like_dom

NELL2 EYS MALRD1 MAMDC2 SLIT3 ADGRG6

1.23e-04219666IPR013320
DomainNotch_dom

NOTCH1 NOTCH2

2.55e-047662IPR000800
DomainNotch

NOTCH1 NOTCH2

2.55e-047662PF00066
DomainNL

NOTCH1 NOTCH2

2.55e-047662SM00004
Domain-

NELL2 EYS SLIT3 ADGRG6

3.56e-04956642.60.120.200
DomainLaminin_G_2

NELL2 EYS SLIT3

3.79e-0440663PF02210
DomainLamG

NELL2 EYS SLIT3

5.03e-0444663SM00282
DomainTIL_dom

LRP2 SSPOP

1.09e-0314662IPR002919
DomainLaminin_G

NELL2 EYS SLIT3

1.13e-0358663IPR001791
DomainMAM

MALRD1 MAMDC2

1.62e-0317662SM00137
DomainMAM

MALRD1 MAMDC2

1.81e-0318662PF00629
DomainMAM_dom

MALRD1 MAMDC2

1.81e-0318662IPR000998
DomainMAM_2

MALRD1 MAMDC2

1.81e-0318662PS50060
DomainCTCK_1

SLIT3 SSPOP

1.81e-0318662PS01185
DomainZnf_FYVE_PHD

DPF1 MTMR4 KAT6B TRIM24

1.82e-03147664IPR011011
DomainVWC_out

NELL2 SSPOP

2.02e-0319662SM00215
DomainPHD

DPF1 KAT6B TRIM24

2.37e-0375663PF00628
DomainZnf_PHD-finger

DPF1 KAT6B TRIM24

2.75e-0379663IPR019787
DomainCys_knot_C

SLIT3 SSPOP

3.50e-0325662IPR006207
DomainCTCK_2

SLIT3 SSPOP

3.50e-0325662PS01225
Domain-

SMPD3 TDP2

3.78e-03266623.60.10.10
DomainExo_endo_phos

SMPD3 TDP2

3.78e-0326662PF03372
DomainPHD

DPF1 KAT6B TRIM24

3.85e-0389663SM00249
DomainEndo/exonuclease/phosphatase

SMPD3 TDP2

4.08e-0327662IPR005135
DomainZnf_PHD

DPF1 KAT6B TRIM24

4.10e-0391663IPR001965
DomainZF_PHD_2

DPF1 KAT6B TRIM24

4.63e-0395663PS50016
DomainZF_PHD_1

DPF1 KAT6B TRIM24

4.76e-0396663PS01359
Domain-

DPF1 MTMR4 SCAF11 KAT6B TRIM24 USP33

5.02e-034496663.30.40.10
DomainZnf_RING/FYVE/PHD

DPF1 MTMR4 SCAF11 KAT6B TRIM24 USP33

5.58e-03459666IPR013083
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

TGFBR2 WNT11 LRP5 TMPRSS4 NOTCH1 NOTCH2

1.67e-05161486M39770
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

VLDLR NPC1L1 LRP1 LRP2 LRP5 TMPRSS4 LRP1B USP33

3.87e-05381488M48063
PathwayKEGG_DORSO_VENTRAL_AXIS_FORMATION

ETS2 NOTCH1 NOTCH2

7.13e-0524483M11190
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH1 NOTCH2

1.13e-045482M27411
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH1 NOTCH2

1.69e-046482M27068
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

TGFBR2 MTMR4 ITGB8

2.87e-0438483MM14874
PathwayREACTOME_REGULATION_OF_COMMISSURAL_AXON_PATHFINDING_BY_SLIT_AND_ROBO

NELL2 SLIT3

5.02e-0410482M27348
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

TGFBR2 MTMR4 ITGB8

5.41e-0447483M646
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH1 NOTCH2

6.12e-0411482M47865
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

WNT11 LRP5 NOTCH1 NOTCH2

6.83e-04118484M39852
PathwayBIOCARTA_HES_PATHWAY

NOTCH1 NOTCH2

7.33e-0412482MM1562
PathwayBIOCARTA_HES_PATHWAY

NOTCH1 NOTCH2

7.33e-0412482M22042
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH1 NOTCH2

7.33e-0412482M47532
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH1 NOTCH2

7.33e-0412482M47533
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

NOTCH1 NOTCH2

8.65e-0413482M47423
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NOTCH1 NOTCH2

8.65e-0413482M47534
PathwayWP_FAMILIAL_HYPERLIPIDEMIA_TYPE_3

VLDLR LRP1

8.65e-0413482M42551
PathwayWP_NEUROGENESIS_REGULATION_IN_THE_OLFACTORY_EPITHELIUM

VLDLR SEMA4A NOTCH1

9.53e-0457483M48326
PathwayPID_NOTCH_PATHWAY

SSPOP NOTCH1 NOTCH2

1.05e-0359483M17
PathwayREACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING

TGFBR2 MTMR4

1.32e-0316482MM14873
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

SSPOP NOTCH1 NOTCH2

1.59e-0368483M27303
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH1 NOTCH2

1.68e-0318482M614
PathwayWP_BREAST_CANCER_PATHWAY

WNT11 LRP5 NOTCH1 NOTCH2

1.83e-03154484M39739
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

VLDLR SLIT3 SEMA4A USP33 ADGRG6

1.87e-03261485MM15676
PathwayWP_HEAD_AND_NECK_SQUAMOUS_CELL_CARCINOMA

TGFBR2 NOTCH1 NOTCH2

2.03e-0374483M39857
PathwayREACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

NOTCH1 NOTCH2

2.07e-0320482M27881
PathwayREACTOME_SIGNALING_BY_ROBO_RECEPTORS

SLIT3 USP33

2.07e-0320482MM14974
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

TGFBR2 MTMR4 ITGB8

2.27e-0377483MM14670
PathwayWP_EXTRACELLULAR_VESICLES_IN_THE_CROSSTALK_OF_CARDIAC_CELLS

SORBS2 ETS2

2.29e-0321482M39735
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

VLDLR LRP1 LRP2 LRP5 LRP1B

4.19e-102166521337463
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

VLDLR FLT1 LRP1 LRP2 LRP1B NOTCH1 NOTCH2

9.54e-1010166723382219
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1 LRP2 LRP5 LRP1B

3.86e-091166424639464
Pubmed

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

VLDLR LRP1 LRP2 LRP1B

1.17e-081466415082773
Pubmed

Identification of Thymosin β4 as an effector of Hand1-mediated vascular development.

TGFBR2 FLT1 NOTCH1 NOTCH2

1.59e-081566420975697
Pubmed

Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.

LRP1 LRP2 LRP5

2.61e-0846637775583
Pubmed

Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.

VLDLR LRP1 LRP2

6.51e-08566318685438
Pubmed

Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex.

VLDLR NOTCH1 NOTCH2

1.30e-07666318957219
Pubmed

The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.

VLDLR LRP1 LRP2

2.27e-07766312169628
Pubmed

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.

TGFBR2 VLDLR CACNA2D4 RP1L1 LRP2 LRP5 SEMA4A

3.08e-0723366732290105
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

TMEM67 NELL2 THADA FBN2 LRP1 LRP5 ADGRE2 LRP1B ITGB8 ADAM22 NOTCH1 NOTCH2 DMXL1

3.48e-071201661335696571
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

VLDLR NELL2 SORBS2 ETS2 LRP1 LRP2 TLN2 SMPD3 LRP1B TDP2 ITGB8 ADAM22 USP33

7.44e-071285661335914814
Pubmed

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

QSOX1 TMEM67 SLIT3 LRP1 LRP2

1.38e-0610066525807483
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

QSOX1 NELL2 LRP2 SCAF11 ATP1A3 KAT6B SSPOP NOTCH1 PCDH17

2.19e-0660866916713569
Pubmed

Stage-specific association of apolipoprotein A-I and E in developing mouse retina.

VLDLR LRP1 LRP2

2.34e-061466317389516
Pubmed

A role for notch signaling in human corneal epithelial cell differentiation and proliferation.

NOTCH1 NOTCH2

3.55e-06266217652726
Pubmed

Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture.

NOTCH1 NOTCH2

3.55e-06266224508387
Pubmed

Striking differences of LDL receptor-related protein 1B expression in mouse and human.

LRP1 LRP1B

3.55e-06266215963947
Pubmed

Clinical role of Notch signaling pathway in intraductal papillary mucinous neoplasm of the pancreas.

NOTCH1 NOTCH2

3.55e-06266225041344
Pubmed

Notch controls generation and function of human effector CD8+ T cells.

NOTCH1 NOTCH2

3.55e-06266223380742
Pubmed

Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.

LRP1 LRP2

3.55e-06266234445520
Pubmed

Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.

NOTCH1 NOTCH2

3.55e-06266225866967
Pubmed

Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking.

NOTCH1 NOTCH2

3.55e-06266232423029
Pubmed

Differential Notch1 and Notch2 expression and frequent activation of Notch signaling in gastric cancers.

NOTCH1 NOTCH2

3.55e-06266221466361
Pubmed

Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice.

NOTCH1 NOTCH2

3.55e-06266220069650
Pubmed

Testosterone influenced the expression of Notch1, Notch2 and Jagged1 induced by lipopolysaccharide in macrophages.

NOTCH1 NOTCH2

3.55e-06266215625786
Pubmed

Notch2 signaling is required for potent antitumor immunity in vivo.

NOTCH1 NOTCH2

3.55e-06266220351182
Pubmed

Involvement of Notch in activation and effector functions of γδ T cells.

NOTCH1 NOTCH2

3.55e-06266224489102
Pubmed

Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.

NOTCH1 NOTCH2

3.55e-06266217261636
Pubmed

Motch A and motch B--two mouse Notch homologues coexpressed in a wide variety of tissues.

NOTCH1 NOTCH2

3.55e-0626628440332
Pubmed

The Notch pathway in podocytes plays a role in the development of glomerular disease.

NOTCH1 NOTCH2

3.55e-06266218311147
Pubmed

Recurrent mutations of NOTCH genes in follicular lymphoma identify a distinctive subset of tumours.

NOTCH1 NOTCH2

3.55e-06266225141821
Pubmed

Differential expression of Notch1 and Notch2 in developing and adult mouse brain.

NOTCH1 NOTCH2

3.55e-0626627609614
Pubmed

Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation.

NOTCH1 NOTCH2

3.55e-06266233017398
Pubmed

Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells.

NOTCH1 NOTCH2

3.55e-06266221285514
Pubmed

Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis.

NOTCH1 NOTCH2

3.55e-06266218353145
Pubmed

Notch signal suppresses Toll-like receptor-triggered inflammatory responses in macrophages by inhibiting extracellular signal-regulated kinase 1/2-mediated nuclear factor κB activation.

NOTCH1 NOTCH2

3.55e-06266222205705
Pubmed

Notch signaling induces cell cycle arrest in small cell lung cancer cells.

NOTCH1 NOTCH2

3.55e-06266211306509
Pubmed

Correlation of asymmetric Notch2 expression and mouse incisor rotation.

NOTCH1 NOTCH2

3.55e-06266210704869
Pubmed

Notch signaling is necessary but not sufficient for differentiation of dendritic cells.

NOTCH1 NOTCH2

3.55e-06266212907456
Pubmed

Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis.

NOTCH1 NOTCH2

3.55e-06266226933171
Pubmed

A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia.

NOTCH1 NOTCH2

3.55e-06266221693515
Pubmed

Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration.

NOTCH1 NOTCH2

3.55e-06266223589286
Pubmed

MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth.

MINAR1 NOTCH2

3.55e-06266229329397
Pubmed

Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice.

VLDLR LRP1

3.55e-06266215327526
Pubmed

Inhibition of granulocytic differentiation by mNotch1.

NOTCH1 NOTCH2

3.55e-0626628917536
Pubmed

Functional conservation of Notch1 and Notch2 intracellular domains.

NOTCH1 NOTCH2

3.55e-06266215897231
Pubmed

Notch signalling suppresses regulatory T-cell function in murine experimental autoimmune uveitis.

NOTCH1 NOTCH2

3.55e-06266227564686
Pubmed

Increased surface expression of NOTCH on memory T cells in peripheral blood from patients with asthma.

NOTCH1 NOTCH2

3.55e-06266230296524
Pubmed

Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells.

NOTCH1 NOTCH2

3.55e-06266212753746
Pubmed

Notch down-regulation in regenerated epidermis contributes to enhanced expression of interleukin-36α and suppression of keratinocyte differentiation during wound healing.

NOTCH1 NOTCH2

3.55e-06266225982147
Pubmed

Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.

NOTCH1 NOTCH2

3.55e-06266219701457
Pubmed

Notch activation on effector T cells increases their sensitivity to Treg cell-mediated suppression through upregulation of TGF-βRII expression.

TGFBR2 NOTCH1

3.55e-06266222585622
Pubmed

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL.

NOTCH1 NOTCH2

3.55e-06266226041884
Pubmed

Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma.

NOTCH1 NOTCH2

3.55e-06266228820917
Pubmed

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.

NOTCH1 NOTCH2

3.55e-06266222006338
Pubmed

Notch1, Notch2, and Epstein-Barr virus-encoded nuclear antigen 2 signaling differentially affects proliferation and survival of Epstein-Barr virus-infected B cells.

NOTCH1 NOTCH2

3.55e-06266219339697
Pubmed

The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer.

NOTCH1 NOTCH2

3.55e-06266215492845
Pubmed

Unravelling disparate roles of NOTCH in bladder cancer.

NOTCH1 NOTCH2

3.55e-06266229643502
Pubmed

Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies.

NOTCH1 NOTCH2

3.55e-06266219915064
Pubmed

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells.

NOTCH1 NOTCH2

3.55e-06266227776108
Pubmed

Notch Inhibition Prevents Differentiation of Human Limbal Stem/Progenitor Cells in vitro.

NOTCH1 NOTCH2

3.55e-06266231316119
Pubmed

Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice.

NOTCH1 NOTCH2

3.55e-06266218666240
Pubmed

In vivo mapping of notch pathway activity in normal and stress hematopoiesis.

NOTCH1 NOTCH2

3.55e-06266223791481
Pubmed

Deletion of LRP5 in VLDLR knockout mice inhibits retinal neovascularization.

VLDLR LRP5

3.55e-06266224058663
Pubmed

Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis.

FLT1 LRP5 NOTCH1

3.59e-061666319154719
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

FAF2 LRP2 SNX29 ADAM22 VPS13B NOTCH2 USP33 DMXL1

5.06e-0650466834432599
Pubmed

Chloride intracellular channel 4 is required for maturation of the cerebral collateral circulation.

TGFBR2 FLT1 NOTCH1

5.22e-061866326276819
Pubmed

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.

VLDLR LRP1 LRP2

5.22e-061866310827173
Pubmed

Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves.

SLIT3 NOTCH1 NOTCH2

6.19e-061966325691540
Pubmed

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.

FLT1 WNT11 LRP5

6.19e-061966321623369
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

DPF1 DCAF1 VLDLR NELL2 THADA FBN2 LRP1 LRP2 KAT6B TRIM24 NOTCH2

7.55e-061116661131753913
Pubmed

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

TGFBR2 FLT1 WNT11 ETS2 LRP5 NOTCH1 NOTCH2

8.28e-0638366719453261
Pubmed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.

TGFBR2 WNT11 SLIT3 LRP5 NOTCH1 NOTCH2

8.42e-0625166629031500
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

FBN2 LRP1 LRP2 SSPOP

1.04e-057166433541421
Pubmed

Angiogenesis-related protein expression in bevacizumab-treated metastatic colorectal cancer: NOTCH1 detrimental to overall survival.

FLT1 NOTCH1

1.06e-05366226394830
Pubmed

Reduced Notch signaling leads to renal cysts and papillary microadenomas.

NOTCH1 NOTCH2

1.06e-05366220378824
Pubmed

Redundant Notch1 and Notch2 signaling is necessary for IFNγ secretion by T helper 1 cells during infection with Leishmania major.

NOTCH1 NOTCH2

1.06e-05366222396647
Pubmed

Helicobacter pylori Infection of Gastric Epithelial Cells Affects NOTCH Pathway In Vitro.

NOTCH1 NOTCH2

1.06e-05366227073072
Pubmed

Clinicopathological analysis of ATRX, DAXX and NOTCH receptor expression in angiosarcomas.

NOTCH1 NOTCH2

1.06e-05366228796347
Pubmed

NOTCH knockdown affects the proliferation and mTOR signaling of leukemia cells.

NOTCH1 NOTCH2

1.06e-05366224122995
Pubmed

Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS).

NOTCH1 NOTCH2

1.06e-05366219797679
Pubmed

The binding sites for the very low density lipoprotein receptor and low-density lipoprotein receptor-related protein are shared within coagulation factor VIII.

VLDLR LRP1

1.06e-05366218277139
Pubmed

Notch signaling regulates follicular helper T cell differentiation.

NOTCH1 NOTCH2

1.06e-05366223918982
Pubmed

Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate.

NOTCH1 NOTCH2

1.06e-0536627615640
Pubmed

Notch Signaling Contributes to Liver Inflammation by Regulation of Interleukin-22-Producing Cells in Hepatitis B Virus Infection.

NOTCH1 NOTCH2

1.06e-05366227800305
Pubmed

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium.

NOTCH1 NOTCH2

1.06e-0536627918097
Pubmed

Complementary and combinatorial patterns of Notch gene family expression during early mouse development.

NOTCH1 NOTCH2

1.06e-0536628645602
Pubmed

Notch signaling confers antigen-presenting cell functions on mast cells.

NOTCH1 NOTCH2

1.06e-05366219130928
Pubmed

Notch1 and Notch2 Coordinately Regulate Stem Cell Function in the Quiescent and Activated States of Muscle Satellite Cells.

NOTCH1 NOTCH2

1.06e-05366229139178
Pubmed

The astrocyte-expressed integrin αvβ8 governs blood vessel sprouting in the developing retina.

TGFBR2 ITGB8

1.06e-05366222069187
Pubmed

Recurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas.

NOTCH1 NOTCH2

1.06e-05366227566587
Pubmed

Expression of Notch1 to -4 and their ligands in renal cell carcinoma: a tissue microarray study.

NOTCH1 NOTCH2

1.06e-05366221471519
Pubmed

Inhibition of fibroblast growth by Notch1 signaling is mediated by induction of Wnt11-dependent WISP-1.

WNT11 NOTCH1

1.06e-05366222715413
Pubmed

MicroRNA expression profiling and Notch1 and Notch2 expression in minimal deviation adenocarcinoma of uterine cervix.

NOTCH1 NOTCH2

1.06e-05366225381598
Pubmed

RBP-Jκ-dependent Notch signaling enhances retinal pigment epithelial cell proliferation in transgenic mice.

NOTCH1 NOTCH2

1.06e-05366220856205
Pubmed

Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner.

NOTCH1 NOTCH2

1.06e-05366217080428
Pubmed

Notch signaling contributes to the expression of cardiac markers in human circulating progenitor cells.

WNT11 NOTCH1

1.06e-05366217967789
Pubmed

Effect of notch1,2,3 genes silicing on NF-κB signaling pathway of macrophages in patients with atherosclerosis.

NOTCH1 NOTCH2

1.06e-05366227697639
Pubmed

Interferon regulatory factor 4 (IRF4) is overexpressed in human non‑small cell lung cancer (NSCLC) and activates the Notch signaling pathway.

NOTCH1 NOTCH2

1.06e-05366228849037
InteractionIGFL3 interactions

TMEM67 VLDLR FBN2 LRP2 LRP5 LRP1B NOTCH1 NOTCH2

1.07e-1075658int:IGFL3
InteractionNTN5 interactions

MTMR4 FBN2 LRP2 LRP1B NOTCH1 NOTCH2

1.14e-1024656int:NTN5
InteractionZFP41 interactions

NELL2 FBN2 LRP1 LRP2 LRP1B NOTCH2

2.84e-0857656int:ZFP41
InteractionZNF408 interactions

VLDLR NELL2 MTMR4 FBN2 LRP2 LRP1B NOTCH2

4.24e-07145657int:ZNF408
InteractionFBXO2 interactions

QSOX1 FLT1 NELL2 FBN2 LRP2 LRP1B NOTCH1 NOTCH2 ADGRG6

6.51e-06411659int:FBXO2
InteractionRAC2 interactions

TGFBR2 FAF2 LRP5 TLN2 SNX29 ADAM22 VPS13B NOTCH1 PCDH17 NOTCH2 ADGRG6

9.33e-066746511int:RAC2
InteractionRAB11A interactions

TGFBR2 MTMR4 AFTPH FAF2 LRP1 LRP2 SEMA4A TDP2 VPS13B NOTCH1 NOTCH2 DMXL1

1.19e-058306512int:RAB11A
InteractionRAB4A interactions

AFTPH FAF2 LRP1 LRP2 SNX29 VPS13B NOTCH1 NOTCH2 DMXL1

1.52e-05457659int:RAB4A
InteractionDKK2 interactions

LRP2 LRP5 LRP1B NOTCH1

1.87e-0549654int:DKK2
InteractionFOXD4L6 interactions

FBN2 LRP1B NOTCH1 NOTCH2

1.87e-0549654int:FOXD4L6
InteractionZNF224 interactions

FBN2 LRP2 LRP1B

3.51e-0520653int:ZNF224
InteractionSULF2 interactions

DCAF1 LRP2 TMPRSS4 LRP1B NOTCH2

4.11e-05119655int:SULF2
InteractionANKRD36B interactions

VLDLR LRP1 LRP2 LRP1B

4.20e-0560654int:ANKRD36B
InteractionFEZF1 interactions

MTMR4 LRP2 LRP1B

9.90e-0528653int:FEZF1
InteractionZNF517 interactions

NPHP3 LRP2 LRP1B

1.10e-0429653int:ZNF517
InteractionTAFA3 interactions

FBN2 LRP2 OTUD4 LRP1B

1.18e-0478654int:TAFA3
InteractionCLU interactions

TGFBR2 VLDLR ETS2 LRP1 LRP2 LRP1B

1.38e-04245656int:CLU
InteractionAPOB interactions

FLT1 FAF2 LRP2 TMPRSS4 SMPD3

1.48e-04156655int:APOB
InteractionITGB1BP1 interactions

LRP1 LRP2 HNRNPH1

1.63e-0433653int:ITGB1BP1
InteractionNDP interactions

TMEM67 LRP5 LRP1B

1.95e-0435653int:NDP
InteractionLPL interactions

VLDLR LRP1 LRP2

1.95e-0435653int:LPL
InteractionTIMP3 interactions

LRP2 LRP5 LRP1B NOTCH2

2.04e-0490654int:TIMP3
InteractionELSPBP1 interactions

QSOX1 TMEM67 NOTCH1 NOTCH2

2.23e-0492654int:ELSPBP1
InteractionWNT10A interactions

LRP5 NOTCH1 NOTCH2

2.30e-0437653int:WNT10A
InteractionGREM2 interactions

FBN2 LRP2 NOTCH2

2.30e-0437653int:GREM2
InteractionCHRM4 interactions

DNAAF5 QSOX1 THADA ATP1A3

2.42e-0494654int:CHRM4
GeneFamilyLow density lipoprotein receptors

VLDLR LRP1 LRP2 LRP5 LRP1B

9.63e-1113455634
GeneFamilyNon-clustered protocadherins

PCDH11Y PCDH17

3.94e-041245221
GeneFamilyPHD finger proteins

DPF1 KAT6B TRIM24

1.46e-039045388
CoexpressionMARIADASON_RESPONSE_TO_BUTYRATE_SULINDAC_6

SORBS2 ETS2 SCAF11 HNRNPH1

5.67e-0647654M1652
CoexpressionLEE_NEURAL_CREST_STEM_CELL_DN

NELL2 SORBS2 FBN2 TRIM24 NOTCH1

1.33e-05122655M10276
CoexpressionLEE_BMP2_TARGETS_UP

VLDLR MAMDC2 LRP1 TMPRSS4 GBP3 SEMA4A EPCAM ITGB8 VPS13B ADGRG6

2.74e-058056510MM1067
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_1000

DPF1 DCAF1 ZIC4 NELL2 THADA MTMR4 SORBS2 FAF2 LRP2 ATP1A3 ITGB8 NOTCH1

3.08e-059796412Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000

ZIC4 NELL2 SORBS2 AFTPH SLIT3 LRP2 SCAF11 SEMA4A ATP1A3 EPCAM ITGB8 ADAM22

3.31e-059866412Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000
CoexpressionAtlasratio_induced-Ectoderm_vs_StemCell_top-relative-expression-ranked_2500_k-means-cluster#3

ZIC4 FBN2 WFIKKN1 MAMDC2 SLIT3 LRP2 WDR86 SMPD3 LRP1B SSPOP PCDH17

4.14e-058486411ratio_ECTO_vs_SC_2500_K3
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_top-relative-expression-ranked_500

VLDLR SORBS2 SLIT3 ETS2 LRP2 EPCAM NOTCH2 ADGRG6

6.57e-05456648gudmap_kidney_P0_JuxtaGlom_Ren1_500
CoexpressionAtlasratio_induced-Ectoderm_vs_StemCell_top-relative-expression-ranked_1000_k-means-cluster#3

ZIC4 WFIKKN1 MAMDC2 SLIT3 LRP2 WDR86 SMPD3 SSPOP

8.23e-05471648ratio_ECTO_vs_SC_1000_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_500

DPF1 ZIC4 NELL2 SORBS2 LRP2 ATP1A3 ITGB8 NOTCH1

9.66e-05482648Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_500
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

QSOX1 FLT1 SORBS2 RP1L1 NOTCH1 ADGRG6

3.51e-071876667170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 WDR86 NOTCH1 PCDH17 ADGRG6

4.91e-0719866636c97eb71b89bac01cabd6a8b728e5a20e52d2a3
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 WDR86 NOTCH1 PCDH17 ADGRG6

5.21e-07200666de55100e98d3e9b8a74e37aebcd3afa2b0996527
ToppCellfacs-Marrow-T-cells-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTMR4 LRP1 SEMA4A ATP1A3 LDLRAD3

5.39e-06170665a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLIT3 LRP1 LRP1B NOTCH2 ADGRG6

5.39e-061706655570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellfacs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTMR4 LRP1 SEMA4A ATP1A3 LDLRAD3

5.39e-06170665ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCellfacs-Aorta|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 LRP2 SSPOP PCDH17 TSPAN33

6.37e-061766650b3491451be02c18a16cdb875645be47eb867a7f
ToppCellfacs-Lung-EPCAM-3m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTMR4 SEMA4A SPATA32 ITGB8 TSPAN33

6.55e-06177665d445167dae956e641386f84ab3ae9f47c089e09a
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NELL2 SLIT3 LRP1B ITGB8 PCDH17

6.92e-06179665065a50952e8703fa07767beb6b73a090bf378ca6
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAMDC2 WNT11 LRP1 ADAM22 ADGRG6

6.92e-0617966502c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAMDC2 SLIT3 LRP1 LDLRAD3 ADAM22

7.11e-0618066508ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellControl-Myeloid-DC1|Control / Condition, Lineage and Cell class

WDR86 SEMA4A EPCAM TSPAN33 ADGRG6

7.30e-061816655a2a1f017ad23baed9972c68b4a46f4c618ef21a
ToppCell3'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGFBR2 FLT1 LDLRAD3 PCDH17 ADGRG6

7.50e-06182665d996ceb77c83591df4cef144ca72862f31d9777f
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAMDC2 WNT11 SLIT3 LRP1 ADGRG6

7.70e-061836657eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 LRP2 TLN2 LRP1B SSPOP

7.91e-061846652cbed6462fea2622871bb7e49b0df3d984239281
ToppCellPBMC-Severe-Hematopoietic-HSPC-HSPC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DPF1 MALRD1 MAMDC2 ADGRG6 DNTT

7.91e-0618466551d0447699e3b8f01abbde83f26b748bc9f3c723
ToppCellPBMC-Severe-Hematopoietic-HSPC-HSPC-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DPF1 MALRD1 MAMDC2 ADGRG6 DNTT

7.91e-06184665f7b0bb45a9055ab34e98b251217f6ec38c75ca22
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 LRP2 TLN2 LRP1B SSPOP

7.91e-06184665ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 LRP2 TLN2 LRP1B SSPOP

7.91e-061846652b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellP28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

QSOX1 FLT1 SORBS2 NOTCH1 ADGRG6

7.91e-061846658ed22b1af04a711203293e7a8b3df6fb9222fad5
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_EGR3|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT3 ETS2 LRP1B ITGB8 PCDH17

7.91e-06184665219bd3b8daa0a713fb6a8a5e1bb35cdb85bb7727
ToppCellPBMC-Severe-Hematopoietic-HSPC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

DPF1 MALRD1 MAMDC2 ADGRG6 DNTT

7.91e-0618466526edbf84216538b80f1ffcc079ee6e385a71fbf9
ToppCellControl-Endothelial-Endothelial-Vein|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 TLN2 LRP1B PCDH17 ADGRG6

8.34e-0618666592092f11ecce22c14f244e42c499af0822977e6f
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 WDR86 NOTCH1 PCDH17 ADGRG6

8.34e-0618666576535681667c8afb884fa72b6edfee9e1e46335b
ToppCellP28-Endothelial-large_vessel_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

QSOX1 FLT1 SORBS2 NOTCH1 ADGRG6

8.78e-06188665263169029293e005bcffd87db20221fdd2d3917e
ToppCellCOPD-Myeloid-cMonocyte|COPD / Disease state, Lineage and Cell class

FLT1 ETS2 LDLRAD3 ADGRE2 NOTCH2

9.01e-06189665d29f3a0bd23e6eb46389e6eb7ef21851c7b57545
ToppCellCOVID-19_Severe-HSPC|World / disease group, cell group and cell class

DPF1 MALRD1 MAMDC2 ADGRG6 DNTT

9.01e-06189665555c0b13f1508b9e3712b36d77144e73e828bc76
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLT1 ADGRE2 NOTCH1 PCDH17 ADGRG6

9.01e-061896651e1afa66b32ae752c0a42b02b80f10205464569c
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 NOTCH1 PCDH17 ADGRG6

9.24e-061906655a82709eeb68df4563bb42b97636d110126d2f97
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SORBS2 LRP2 TLN2 SNX29 ITGB8

9.48e-061916653c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SORBS2 LRP2 TLN2 SNX29 ITGB8

9.48e-061916651c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAMDC2 SLIT3 LRP1 NOTCH2 ADGRG6

9.48e-0619166514057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 ATP1A3 NOTCH1 PCDH17 ADGRG6

9.48e-06191665a53616c84178eb6c29b48662358765b082df3f97
ToppCell5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGFBR2 FLT1 SORBS2 LDLRAD3 ADGRG6

9.72e-06192665eafead22bba48ac5ee568faa8946c444445c1034
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TGFBR2 FLT1 ETS2 LDLRAD3 PCDH17

9.72e-061926651ee4783051ec94ea94600f040edcb385fc4289f1
ToppCellfacs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 LRP5 ADGRE2 NOTCH1 PCDH17

9.72e-061926654bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 WDR86 PCDH17 ADGRG6

9.97e-06193665d5930f7bd9b299f792212d40a3272a37adf64a82
ToppCellFetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLT1 RP1L1 ETS2 NOTCH1 PCDH17

9.97e-06193665ad2df9b77999780860141be6ec366afc0172a331
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGFBR2 FLT1 LDLRAD3 PCDH17 ADGRG6

9.97e-06193665c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCellP15-Endothelial-large_vessel_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

QSOX1 FLT1 SORBS2 NOTCH1 ADGRG6

9.97e-061936655f9a7cd5f8eb9ac294cdb50518fedf872f3f78f5
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 LRP5 ADGRE2 NOTCH1 PCDH17

1.02e-05194665f159ef8541d75a4e98468947f231bb463bec922c
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 MAMDC2 LRP2 ITGB8 ADGRG6

1.02e-051946658ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

QSOX1 MALRD1 EPCAM NOTCH2 ADGRG6

1.05e-0519566523ab7e2a419377c05bab0e92a2457afbcd3d9e07
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

QSOX1 MALRD1 EPCAM NOTCH2 ADGRG6

1.05e-05195665e87b11e3242fdbed2e7f383e6876ec375af32bd4
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLT1 SORBS2 ETS2 PCDH17 ADGRG6

1.05e-0519566581a98ebb0d43f416f9a8bba580531dc0cfea8f74
ToppCellCOVID-19-kidney-VWF+PLVAP+VCAM1+EC|kidney / Disease (COVID-19 only), tissue and cell type

TGFBR2 FLT1 ETS2 LDLRAD3 PCDH17

1.07e-05196665ac2c4a325efa8497a755cd31fb6a9d94d8e3bf42
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TGFBR2 FLT1 ETS2 PCDH17 ADGRG6

1.07e-0519666595c5b8fd4ebfae1f42de9b1475c1161d4a80e515
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGFBR2 FLT1 LDLRAD3 PCDH17 ADGRG6

1.10e-0519766587eda06344498dc66cac292cf89746dc90b5cf67
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 WDR86 PCDH17 ADGRG6

1.10e-05197665bb35a2b7320fda92e9cd42f536b7bd54e3a73a32
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLT1 SORBS2 ETS2 PCDH17 ADGRG6

1.10e-051976650542badae77d2f606c13cfaf361319495c354351
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 WDR86 PCDH17 ADGRG6

1.10e-051976651018aac22659c081d227d566afa29b1748c18ade
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLT1 SORBS2 ETS2 PCDH17 ADGRG6

1.10e-05197665a6a64581699cfcb9607b288976fa3b09648725b7
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 WDR86 PCDH17 ADGRG6

1.13e-0519866550dfe6efca76ea9683a19b6bff59cb5030d346f1
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 WDR86 NOTCH1 PCDH17 ADGRG6

1.13e-05198665c8272ac4d90f2367f538f66db40de911ad73ea7f
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 WDR86 PCDH17 ADGRG6

1.13e-051986656e314dc820db9c53fe7fc7c96bed4d7d9a325160
ToppCellEndothelial_cells-Endothelial-A|Endothelial_cells / lung cells shred on cell class, cell subclass, sample id

FLT1 SORBS2 ETS2 PCDH17 ADGRG6

1.16e-051996652a1424c61ddcd1fea9574f7a3ad1955387458130
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 WDR86 NOTCH1 PCDH17 ADGRG6

1.16e-05199665ce699726ac4825c65bf934cb9a76202ad7340596
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 WDR86 NOTCH1 PCDH17 ADGRG6

1.16e-05199665f1d5808ccb1d5d4e2d34f864e705e2484000e88f
ToppCellcellseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TGFBR2 FLT1 SORBS2 PCDH17 ADGRG6

1.16e-0519966568412bc39639edc4045437d62548f7101b9f1989
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 WDR86 PCDH17 ADGRG6

1.16e-05199665a76aa30fb264bdcbc0cb09113f814fc5a89e7319
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 WDR86 PCDH17 ADGRG6

1.16e-051996655f350d9c7da9ac111bf22623dd4fed7f7983c9fc
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SORBS2 ETS2 ITGB8 HNRNPH1 ADGRG6

1.16e-05199665174f6013af6eafa577f84205a62927f2b367fda3
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 ATP1A3 PCDH17 ADGRG6

1.16e-0519966547466253069d4b1b8f13ce3210f434e60753b38a
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 WDR86 NOTCH1 PCDH17 ADGRG6

1.16e-051996658d13a9ea87f685b5a34b84c4571db6be753cf2d9
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 WDR86 PCDH17 ADGRG6

1.16e-051996651761669ec514fdb4175042f11b9a31fa5687fc2b
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 WDR86 PCDH17 ADGRG6

1.16e-05199665a816b0eed80530113b7e720bbd2311a544ed8ed1
ToppCellLung_Parenchyma-Severe-Myeloid-Macrophage-Macrophages-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TGFBR2 FLT1 ETS2 PCDH17 ADGRG6

1.18e-05200665e6d36be0c4c569e27303bb4e4f34cd2187e9759d
ToppCellTracheal|World / Cell types per location group and 10X technology with lineage, and cell group designations

SORBS2 SLIT3 TMPRSS4 LDLRAD3 ITGB8

1.18e-05200665682960e28542a3d6c119047cd0131941932cfdea
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 WDR86 PCDH17 ADGRG6

1.18e-05200665363a8cebf2ace820661bcb87c7941f6671f8e5f3
ToppCellParenchyma_COVID-19-Endothelial-TX-Macrophages|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

TGFBR2 FLT1 ETS2 PCDH17 ADGRG6

1.18e-05200665c0c51719cf81512c50bfcc2fed883c867e522d2a
ToppCell390C-Endothelial_cells-Endothelial-A_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FLT1 SORBS2 ETS2 LDLRAD3 PCDH17

1.18e-0520066550b8788494b744e0f0ec8c4d67a1c90ae09dca65
ToppCell390C-Endothelial_cells-Endothelial-A_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FLT1 SORBS2 ETS2 LDLRAD3 PCDH17

1.18e-05200665f5f24273bee3259a4a3be99ba53b88defa1286c0
ToppCellLung_Parenchyma-Severe-Myeloid-Macrophage|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

TGFBR2 FLT1 ETS2 PCDH17 ADGRG6

1.18e-05200665758840c31f2ddd7ccf7bf13252ebb48d33e89479
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_only / Treatment groups by lineage, cell group, cell type

MAMDC2 LRP1 WDR86 ADAM22 ADGRG6

1.18e-05200665a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 ATP1A3 NOTCH1 PCDH17 ADGRG6

1.18e-05200665553e9612874480f4d2a45671462e266cd0a09321
ToppCellLung_Parenchyma-Severe-Myeloid-Macrophage-Macrophages|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

TGFBR2 FLT1 ETS2 PCDH17 ADGRG6

1.18e-05200665c37fe06a94e5779c56e01389869bb432d3bbaebc
ToppCellControl|World / 5 Neutrophil clusters in COVID-19 patients

DPF1 GLIPR1L2 ADGRE2 EPCAM

2.33e-05112664b3e5a901f3dbd6e49e968dd2a371f68274951735
ToppCellLPS-antiTNF-Myeloid-Monocytes,_Macrophages-T-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MALRD1 SEMA4A ADGRE2 SPATA32

4.98e-05136664186be8e1595608004b8216892cb9c7a7f31fbb4d
ToppCellControl-Neu_1|World / 5 Neutrophil clusters in COVID-19 patients

DPF1 GLIPR1L2 ADGRE2 EPCAM

5.27e-05138664b7920c9a28d28220e7e4b30cd91ba13d0548eb76
ToppCellCOVID-19-kidney-Technical/muscle_(EC)|kidney / Disease (COVID-19 only), tissue and cell type

FLT1 EYS MALRD1 PCDH11Y

5.42e-0513966464c35411bbe67acb5010dadc4b0b1be0f8b17737
ToppCellLPS-antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 CACNA2D4 LRP2 TLN2

6.22e-051446641b9e95e4f6e40042d3cf2f94c067f3a6b19428ea
ToppCelldroplet-Lung-nan-3m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTMR4 WNT11 WDR86 TSPAN33

7.67e-0515266477b319f594d5e4df29034bbf69c7490076f89dd3
ToppCellfacs-Brain_Myeloid-Cortex-3m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 LDLRAD3 ADGRE2 ADGRG6

7.86e-051536640ef7c45cdd854c79e527006034029767f8e108b2
ToppCelldroplet-Lung-nan-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1A3 LDLRAD3 ADGRE2 NOTCH2

7.86e-051536646dcab3d50ab50051955204dc4e4a64c1ca855bcd
ToppCelldroplet-Lung-nan-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1A3 LDLRAD3 ADGRE2 NOTCH2

7.86e-05153664f6ef14d949107c08cb3690e26ec91e194cb43518
ToppCellileum-BEST4+_Enterocytes|ileum / shred on tissue and cell subclass

QSOX1 TDP2 NOTCH2 ADGRG6

8.07e-05154664608e9c982125e0c2c15b86b1920813845a0db81f
ToppCell5'-Adult-Appendix-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

QSOX1 VLDLR TRIM24 NOTCH2

8.27e-051556645fabe24a784f0be46040ffc886eabd8d5ce78121
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP5 SMPD3 TSPAN33 ADGRG6

8.69e-0515766419c0599a669803c4db1f174de1ce755e562a50a3
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FLT1 ETS2 LRP1 LDLRAD3

9.13e-05159664fb9a45c1d596226128ce4f1adaebb066766e590a
ToppCellfacs-Spleen-nan-3m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 ATP1A3 TSPAN33 ADGRG6

9.58e-0516166445591addc765760db6029ac19e80573373d1d917
ToppCellfacs-Spleen-nan-3m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 ATP1A3 TSPAN33 ADGRG6

9.58e-051616648741b91a62c9a8ce377ef6533d323b65beb93c63
ToppCellfacs-Spleen-nan-3m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 ATP1A3 TSPAN33 ADGRG6

9.58e-051616649cf1dcf0e7ca9e35c46c094a6b78f98d1f6b9276
ToppCell368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

NPHP3 MAMDC2 TSPAN33 ADGRG6

1.00e-041636644b8abbad4df040c895e3afb240759ebbc66b4d0e
ToppCellIIF-Other-HSPC|IIF / Disease, Lineage and Cell Type

DPF1 MAMDC2 EPCAM ADGRG6

1.00e-041636641e0d38fbed38ac48478868a1480172a1a3f7c1b7
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_B|E18.5-samps / Age Group, Lineage, Cell class and subclass

FLT1 GBP3 ADGRE2 PCDH17

1.00e-04163664d6f9b7280c44d120df5a72dfc2ebb26ffbb5752b
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NELL2 SORBS2 PCDH17 ADGRG6

1.03e-0416466457301178e420983c0cb72178e288a3a0449fdda3
ToppCellMultiple_Sclerosis-Other-HSPC|Multiple_Sclerosis / Disease, Lineage and Cell Type

DPF1 MALRD1 MAMDC2 ADGRG6

1.03e-041646646af5529507d695b347adee4be5ead70f56c9cf55
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLT1 SORBS2 NOTCH1 ADGRG6

1.08e-041666647a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCellwk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

MALRD1 LRP1 VPS13B TSPAN33

1.08e-0416666465dafed953b01a9830b54309af75c7a561e88336
ToppCelldroplet-Lung-LUNG-1m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 ATP1A3 LDLRAD3 NOTCH2

1.08e-04166664dd5944101ef58a9a29aa3eb5c17690119572b8f1
DrugBezafibrate [41859-67-0]; Up 200; 11uM; PC3; HT_HG-U133A

FLT1 NELL2 LRP1 TMPRSS4 SNX29 ITGB8 ADAM22 NOTCH1

1.02e-071976686653_UP
Drugprobucol

VLDLR NPHP3 NPC1L1 LRP1 LRP2 LRP5 LRP1B

4.44e-07162667CID000004912
Drug25-hydroxycholesterol

NPC1L1 LRP1 LRP2 SMPD3 LRP1B NOTCH2

7.03e-06160666CID000065094
DrugQuinethazone [73-49-4]; Up 200; 13.8uM; PC3; HT_HG-U133A

VLDLR FLT1 LRP1 TLN2 MINAR1 ADGRE2

2.36e-051986664529_UP
Drugvaldecoxib; Up 200; 10uM; MCF7; HT_HG-U133A

DPF1 ZIC4 NELL2 SMPD3 ADAM22 HNRNPH1

2.50e-052006666403_UP
DrugEpivincamine [6835-99-0]; Up 200; 11.2uM; MCF7; HT_HG-U133A

LRP2 TMPRSS4 TLN2 MINAR1 ADAM22 VPS13B

2.50e-052006666838_UP
DiseaseDisorder of eye

TMEM67 EYS CACNA2D4 NPHP3 LRP5 SEMA4A

7.43e-06212656C0015397
DiseaseHereditary Nonpolyposis Colorectal Neoplasms

TGFBR2 SEMA4A EPCAM

2.56e-0526653C0009405
DiseaseHereditary non-polyposis colorectal cancer syndrome

TGFBR2 SEMA4A EPCAM

2.87e-0527653C1112155
DiseaseHereditary Nonpolyposis Colorectal Cancer

TGFBR2 SEMA4A EPCAM

3.58e-0529653C1333990
Diseasesmoking status measurement, chronic obstructive pulmonary disease

OTUD4 SMPD3 ITGB8 ADGRG6

4.35e-0588654EFO_0000341, EFO_0006527
Diseasepack-years measurement, systolic blood pressure

CACNA2D4 LRP2 LRP1B

5.81e-0534653EFO_0006335, EFO_0006526
Diseasenephronophthisis (is_implicated_in)

TMEM67 NPHP3

7.13e-056652DOID:12712 (is_implicated_in)
Diseaseadenocarcinoma (implicated_via_orthology)

NOTCH1 NOTCH2

9.96e-057652DOID:299 (implicated_via_orthology)
Diseasecentral nervous system cancer (implicated_via_orthology)

NOTCH1 NOTCH2

9.96e-057652DOID:3620 (implicated_via_orthology)
DiseaseNephronophthisis

TMEM67 NPHP3

1.70e-049652cv:C0687120
DiseaseAbdominal Migraine

TGFBR2 LRP1

1.70e-049652C0270858
DiseaseSick Headaches

TGFBR2 LRP1

1.70e-049652C0700438
DiseaseAcute Confusional Migraine

TGFBR2 LRP1

1.70e-049652C0521664
DiseaseLynch Syndrome

TGFBR2 EPCAM

1.70e-049652C4552100
DiseaseStatus Migrainosus

TGFBR2 LRP1

1.70e-049652C0338489
DiseaseCervical Migraine Syndrome

TGFBR2 LRP1

1.70e-049652C0007852
DiseaseHemicrania migraine

TGFBR2 LRP1

1.70e-049652C0018984
Diseasemood instability measurement

EYS LRP1B PCDH17 ADGRG6

1.86e-04128654EFO_0008475
DiseaseMeckel-Gruber syndrome

TMEM67 NPHP3

2.13e-0410652cv:C0265215
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

TGFBR2 FBN2 NOTCH1

2.21e-0453653C4707243
Diseaserespiratory system disease

DCAF1 WNT11 SPATA32 ITGB8

3.00e-04145654EFO_0000684
DiseaseMalignant neoplasm of skin

FLT1 NOTCH1 NOTCH2

3.04e-0459653C0007114
DiseaseSkin Neoplasms

FLT1 NOTCH1 NOTCH2

3.04e-0459653C0037286
Diseasecongenital diaphragmatic hernia (implicated_via_orthology)

SLIT3 LRP1

3.11e-0412652DOID:3827 (implicated_via_orthology)
Diseaseretinopathy of prematurity (biomarker_via_orthology)

FLT1 NOTCH1

3.11e-0412652DOID:13025 (biomarker_via_orthology)
Diseasexanthine measurement

EYS ADAM22

3.67e-0413652EFO_0010548
DiseaseMigraine Disorders

TGFBR2 LRP1

3.67e-0413652C0149931
DiseaseNephronophthisis

TMEM67 NPHP3

3.67e-0413652C0687120
DiseaseCraniofacial Abnormalities

TGFBR2 ETS2 LRP2 NOTCH1

3.96e-04156654C0376634
DiseaseProstatic Neoplasms

TGFBR2 FAF2 PCDH11Y LRP2 EPCAM LRP1B HNRNPH1

4.08e-04616657C0033578
DiseaseMalignant neoplasm of prostate

TGFBR2 FAF2 PCDH11Y LRP2 EPCAM LRP1B HNRNPH1

4.08e-04616657C0376358
Diseaseurate measurement, bone density

EYS ETS2 GLIPR1L2 GBP3 KAT6B SNX29 PCDH17

4.20e-04619657EFO_0003923, EFO_0004531
Diseaseautosomal dominant polycystic kidney disease (implicated_via_orthology)

NPHP3 LRP5

4.27e-0414652DOID:898 (implicated_via_orthology)
DiseaseNeoplasm of uncertain or unknown behavior of bladder

NOTCH1 NOTCH2

4.93e-0415652C0496930
DiseaseBenign neoplasm of bladder

NOTCH1 NOTCH2

4.93e-0415652C0154017
DiseaseCarcinoma in situ of bladder

NOTCH1 NOTCH2

4.93e-0415652C0154091
Diseaseidiopathic scoliosis (implicated_via_orthology)

SSPOP ADGRG6

5.62e-0416652DOID:0060250 (implicated_via_orthology)
DiseaseVan Buchem disease

FLT1 LRP5

6.36e-0417652C0432272
DiseaseCarcinoma of bladder

NOTCH1 NOTCH2

7.15e-0418652C0699885
DiseaseMeckel syndrome type 1

TMEM67 NPHP3

7.15e-0418652C3714506
Diseasealcohol use disorder (implicated_via_orthology)

DPF1 ATP1A3 NOTCH1 NOTCH2

9.14e-04195654DOID:1574 (implicated_via_orthology)
Diseaseschizophrenia, intelligence, self reported educational attainment

DCAF1 SMPD3 LRP1B SNX29 PCDH17

1.00e-03346655EFO_0004337, EFO_0004784, MONDO_0005090
DiseaseSquamous cell carcinoma of esophagus

TGFBR2 NOTCH1 NOTCH2

1.22e-0395653C0279626
DiseaseCerebral Astrocytoma

NOTCH1 NOTCH2

1.39e-0325652C0750935
DiseaseIntracranial Astrocytoma

NOTCH1 NOTCH2

1.39e-0325652C0750936
DiseasePilocytic Astrocytoma

NOTCH1 NOTCH2

1.39e-0325652C0334583
DiseaseAstrocytoma

NOTCH1 NOTCH2

1.39e-0325652C0004114
DiseaseJuvenile Pilocytic Astrocytoma

NOTCH1 NOTCH2

1.39e-0325652C0280783
DiseaseDiffuse Astrocytoma

NOTCH1 NOTCH2

1.39e-0325652C0280785
DiseaseGrade I Astrocytoma

NOTCH1 NOTCH2

1.39e-0325652C1704230
DiseaseSubependymal Giant Cell Astrocytoma

NOTCH1 NOTCH2

1.39e-0325652C0205768
DiseaseMixed oligoastrocytoma

NOTCH1 NOTCH2

1.39e-0325652C0547065
DiseaseChildhood Cerebral Astrocytoma

NOTCH1 NOTCH2

1.39e-0325652C0338070
Diseasefree androgen index

THADA LRP5 TMPRSS4 MINAR1 SMPD3

1.41e-03374655EFO_0007005
Diseasebrain cancer (implicated_via_orthology)

NOTCH1 NOTCH2

1.50e-0326652DOID:1319 (implicated_via_orthology)
DiseaseGemistocytic astrocytoma

NOTCH1 NOTCH2

1.50e-0326652C0334581
DiseaseProtoplasmic astrocytoma

NOTCH1 NOTCH2

1.50e-0326652C0334580
DiseaseFibrillary Astrocytoma

NOTCH1 NOTCH2

1.50e-0326652C0334582
DiseaseAnaplastic astrocytoma

NOTCH1 NOTCH2

1.62e-0327652C0334579
Diseasebody weight

EYS FBN2 SLIT3 TLN2 SMPD3 KAT6B TRIM24 LRP1B ADGRG6

1.71e-031261659EFO_0004338
DiseaseCone-Rod Dystrophy 2

CACNA2D4 SEMA4A

1.87e-0329652C3489532
Diseasebipolar disorder (is_implicated_in)

ATP1A3 KAT6B

1.87e-0329652DOID:3312 (is_implicated_in)
Diseaseopioid dependence

ZIC4 TLN2 WDR86 TSPAN33

1.87e-03237654EFO_0005611
Diseasecolorectal cancer (implicated_via_orthology)

NOTCH1 NOTCH2

2.00e-0330652DOID:9256 (implicated_via_orthology)
Diseasepneumonia, COVID-19

NELL2 LRP1B VPS13B

2.01e-03113653EFO_0003106, MONDO_0100096

Protein segments in the cluster

PeptideGeneStartEntry
ATATFAAAQEECVCE

EPCAM

16

P16422
NNTVCEDVDECSSGQ

ADGRE2

206

Q9UHX3
DSSNDFVTCNDINED

AFTPH

416

Q6ULP2
RDSDASETVCLCNHF

ADGRG6

826

Q86SQ4
CGTSENDDQLLFCDD

DPF1

331

Q92782
AVNDCDIRETCSGNS

ADAM22

506

Q9P0K1
QRTCDFCSDAEELQS

DMXL1

2071

Q9Y485
DQADSDQDTNKGSCC

PCDH17

896

O14917
EAPAAQNESDCTCTD

OTUD4

751

Q01804
CAEETNSAVCRDFNI

QSOX1

101

O00391
DDTFQDCAETQEACR

KAT6B

1556

Q8WYB5
SAVEASCNFEQDLCN

MAMDC2

336

Q7Z304
SGDDCSENIDDCAFA

NOTCH2

331

Q04721
FREANEDESGFTCCA

DCAF1

1086

Q9Y4B6
NNCQDNSDEESCESS

LDLRAD3

136

Q86YD5
DCSENIDDCASAACF

NOTCH1

331

P46531
CGSNEDESNQTCTAR

LRP1B

911

Q9NZR2
SNITSNSFICECDEQ

EYS

271

Q5T1H1
IDECSDGFVQCDSRA

NELL2

556

Q99435
DKCTDFLCSNADRDQ

GLIPR1L2

216

Q4G1C9
TCRAVNSSCRAQDEF

LRP1

2516

Q07954
NSSCRAQDEFECANG

LRP1

2521

Q07954
SSRCNQFVDCEDASD

LRP1

2621

Q07954
ADCQDRSDEADCDAI

LRP5

1321

O75197
FESFEDDCSQSLCLN

ETS2

311

P15036
DDFCKQNQEASSDRC

GBP3

391

Q9H0R5
QDCDDGSDERQDCSQ

LRP2

91

P98164
RCDGVFDCSDNSDEA

LRP2

1206

P98164
SCSADEVQRFFSDCK

HNRNPH1

21

P31943
VVCGDFNFDNCSSDD

SMPD3

506

Q9NY59
EACDADFDSSLTACS

MTMR4

281

Q9NYA4
ARCNESQGDDVATCS

NPC1L1

241

Q9UHC9
QGEDNRCASSNAASC

ITGB8

41

P26012
VNDCADNSDETTFIC

MALRD1

1286

Q5VYJ5
QSCEDSDLDCFVIDN

CACNA2D4

881

Q7Z3S7
FDCDDVNFTTDNLCF

ATP1A3

561

P13637
FLDNFQETCNETTSC

KRTAP27-1

46

Q3LI81
EQDLFTDDSCVQSNC

KRTAP27-1

66

Q3LI81
FQACTDEEAAVVQSC

DNAAF5

406

Q86Y56
THNNDCLDIDECSSF

FBN2

1966

P35556
CDSFCSDQNESEVEP

SCAF11

721

Q99590
DNTFVACDSISNCSS

PCDH11Y

1001

Q9BZA8
SQATCELCDGNENSF

TMEM67

146

Q5HYA8
EASFESCRSDTEICN

MINAR1

116

Q9UPX6
TCQSTEFAFCQVDAS

THADA

1761

Q6YHU6
SDSDSRVTCLCAQFE

SNX29

36

Q8TEQ0
EAQDTVFTLDCANQC

SSPOP

4671

A2VEC9
AENCEFRENEDSCVT

DNTT

176

P04053
DDNCTDVTAAGTQCE

NPHP3

216

Q7Z494
DHQDSDEFCRNTLCA

FAF2

181

Q96CS3
ECRTSASDVDADNNC

SEMA4A

741

Q9H3S1
SNCRSFTEENHVSAC

SPATA32

131

Q96LK8
CSCSSDECNDNIIFS

TGFBR2

136

P37173
SRSCDDLLNDDCDSF

SORBS2

381

O94875
IQDFTCDGNEESSCQ

SLIT3

706

O75094
FNCSEDNPSRERCSV

TSPAN33

171

Q86UF1
QVCTSCEDNAEANGF

TRIM24

161

O15164
ACACATNEDEAERDS

RP1L1

1266

Q8IWN7
EFASVASCDAAVAQC

TDP2

31

O95551
ASCDAAVAQCFLAEN

TDP2

36

O95551
ACFDNFTEALAETAC

TMPRSS4

126

Q9NRS4
CEFEGCERRFANSSD

ZIC4

236

Q8N9L1
QSTCERECSRDQDCA

WFIKKN1

46

Q96NZ8
DRQCNKTSNGSDSCD

WNT11

296

O96014
NRSETEACFFICGDN

VPS13B

471

Q7Z7G8
ENCVRACQAATTDSE

TLN2

751

Q9Y4G6
FACSQCEAQFSSETA

ZNF142

1286

P52746
SEARCDFCSNNEESF

FLT1

476

P17948
TFCQLEDEAAFTCSA

WDR86

61

Q86TI4
EDEAAFTCSADCTIR

WDR86

66

Q86TI4
VDFQSCESCSNSDRA

USP33

316

Q8TEY7
CESCSNSDRAENENG

USP33

321

Q8TEY7
ADCSDQSDESLEQCG

VLDLR

216

P98155