Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	metalloendopeptidase activity	YBEY PAPPA MMP1 MMP12 MMP26	2.78e-05	120	59	5	GO:0004222
GeneOntologyMolecularFunction	metallopeptidase activity	YBEY PAPPA MMP1 MMP12 MMP26	3.10e-04	200	59	5	GO:0008237
Domain	-	ZXDC ZNF600 ZNF142 ZNF497 ZNF660 ZNF607 ZNF644 ZNF846 ZNF726 GFI1 ZFP82 ZNF181 ZXDB	1.21e-07	679	58	13	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZXDC ZNF600 ZNF142 ZNF497 ZNF660 ZNF607 ZNF644 ZNF846 ZNF726 GFI1 ZFP82 ZNF181 ZXDB	1.55e-07	694	58	13	IPR013087
Domain	zf-C2H2_6	ZNF600 ZNF497 ZNF660 ZNF607 ZNF846 ZNF726 GFI1 ZFP82 ZNF181	4.94e-07	314	58	9	PF13912
Domain	ZINC_FINGER_C2H2_2	ZXDC ZNF600 ZNF142 ZNF497 ZNF660 ZNF607 ZNF644 ZNF846 ZNF726 GFI1 ZFP82 ZNF181 ZXDB	5.48e-07	775	58	13	PS50157
Domain	ZINC_FINGER_C2H2_1	ZXDC ZNF600 ZNF142 ZNF497 ZNF660 ZNF607 ZNF644 ZNF846 ZNF726 GFI1 ZFP82 ZNF181 ZXDB	5.64e-07	777	58	13	PS00028
Domain	Znf_C2H2-like	ZXDC ZNF600 ZNF142 ZNF497 ZNF660 ZNF607 ZNF644 ZNF846 ZNF726 GFI1 ZFP82 ZNF181 ZXDB	7.40e-07	796	58	13	IPR015880
Domain	Znf_C2H2	ZXDC ZNF600 ZNF142 ZNF497 ZNF660 ZNF607 ZNF644 ZNF846 ZNF726 GFI1 ZFP82 ZNF181 ZXDB	8.40e-07	805	58	13	IPR007087
Domain	ZnF_C2H2	ZXDC ZNF600 ZNF142 ZNF497 ZNF660 ZNF607 ZNF644 ZNF846 ZNF726 GFI1 ZFP82 ZNF181 ZXDB	8.76e-07	808	58	13	SM00355
Domain	zf-C2H2	ZNF600 ZNF142 ZNF497 ZNF660 ZNF607 ZNF644 ZNF846 ZNF726 GFI1 ZFP82 ZNF181 ZXDB	1.15e-06	693	58	12	PF00096
Domain	M10A_MMP	MMP1 MMP12 MMP26	4.82e-05	23	58	3	IPR033739
Domain	Pept_M10A	MMP1 MMP12 MMP26	4.82e-05	23	58	3	IPR021190
Domain	Peptidase_M10	MMP1 MMP12 MMP26	5.49e-05	24	58	3	PF00413
Domain	ZnMc	MMP1 MMP12 MMP26	9.81e-05	29	58	3	SM00235
Domain	Peptidase_Metallo	MMP1 MMP12 MMP26	9.81e-05	29	58	3	IPR006026
Domain	MetalloPept_cat_dom	PAPPA MMP1 MMP12 MMP26	1.17e-04	81	58	4	IPR024079
Domain	-	PAPPA MMP1 MMP12 MMP26	1.17e-04	81	58	4	3.40.390.10
Domain	ZINC_PROTEASE	PAPPA MMP1 MMP12 MMP26	2.43e-04	98	58	4	PS00142
Domain	CYSTEINE_SWITCH	MMP1 MMP12 MMP26	2.79e-04	41	58	3	PS00546
Domain	Pept_M10_metallopeptidase	MMP1 MMP12 MMP26	3.21e-04	43	58	3	IPR001818
Domain	ZnF_BED	ZNF846 ZNF181	5.12e-04	11	58	2	SM00614
Domain	Znf_BED	ZNF846 ZNF181	6.13e-04	12	58	2	IPR003656
Domain	KRAB	ZNF607 ZNF846 KRBA2 ZNF726 ZFP82 ZNF181	8.31e-04	358	58	6	PS50805
Domain	KRAB	ZNF607 ZNF846 KRBA2 ZNF726 ZFP82 ZNF181	8.31e-04	358	58	6	PF01352
Domain	Pept_M10A_Zn_BS	MMP1 MMP12	9.70e-04	15	58	2	IPR021158
Domain	KRAB	ZNF607 ZNF846 KRBA2 ZNF726 ZFP82 ZNF181	9.72e-04	369	58	6	SM00349
Domain	KRAB	ZNF607 ZNF846 KRBA2 ZNF726 ZFP82 ZNF181	9.86e-04	370	58	6	IPR001909
Domain	Hemopexin_CS	MMP1 MMP12	1.25e-03	17	58	2	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP1 MMP12	1.40e-03	18	58	2	IPR016293
Domain	Apc4_WD40_dom	EML5 WDR47	1.74e-03	20	58	2	IPR024977
Domain	ANAPC4_WD40	EML5 WDR47	1.74e-03	20	58	2	PF12894
Domain	PG_binding_1	MMP1 MMP12	1.74e-03	20	58	2	PF01471
Domain	Peptidoglycan-bd-like	MMP1 MMP12	1.74e-03	20	58	2	IPR002477
Domain	Hemopexin-like_dom	MMP1 MMP12	2.30e-03	23	58	2	IPR000585
Domain	Hemopexin-like_repeat	MMP1 MMP12	2.30e-03	23	58	2	IPR018487
Domain	Hemopexin	MMP1 MMP12	2.30e-03	23	58	2	PF00045
Domain	HEMOPEXIN	MMP1 MMP12	2.30e-03	23	58	2	PS00024
Domain	-	MMP1 MMP12	2.30e-03	23	58	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP1 MMP12	2.30e-03	23	58	2	PS51642
Domain	HX	MMP1 MMP12	2.30e-03	23	58	2	SM00120
Domain	GPS	CELSR2 ADGRD2	4.99e-03	34	58	2	SM00303
Domain	GPS	CELSR2 ADGRD2	5.28e-03	35	58	2	PF01825
Domain	UBA	VPS13D NBR1	5.58e-03	36	58	2	PF00627
Domain	GPS	CELSR2 ADGRD2	5.58e-03	36	58	2	PS50221
Domain	GPS	CELSR2 ADGRD2	5.89e-03	37	58	2	IPR000203
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP1 MMP12 MMP26	8.15e-05	30	40	3	M39652
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ZNF600 AOC1 EML5 GLG1 FAM91A1 EIF2AK4 MMP1 SLC1A3 TAPBP ZNF726 ZFP82	1.82e-06	1084	59	11	11544199
Pubmed	Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.	MMP1 MMP12	2.83e-06	2	59	2	8226919
Pubmed	Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking.	MMP1 MMP12	2.83e-06	2	59	2	30789935
Pubmed	The Immunological Roles of Periostin/Tumor-Associated Macrophage Axis in Development of Dermatofibrosarcoma Protuberans.	MMP1 MMP12	2.83e-06	2	59	2	28551623
Pubmed	Matrix metalloproteinase-1 and matrix metalloproteinase-12 gene polymorphisms and the risk of ischemic stroke in a Tunisian population.	MMP1 MMP12	2.83e-06	2	59	2	24834994
Pubmed	MMP Gene Polymorphisms, MMP-1 -1607 1G/2G, -519 A/G, and MMP-12 -82 A/G, and Ischemic Stroke: A Meta-Analysis.	MMP1 MMP12	2.83e-06	2	59	2	28958661
Pubmed	THE ROLE OF POLYMORPHISMS OF MATRIX METALLOPROTEINASES' POLYMORPHISMS 1 AND 12 IN THE FORMATION OF WHEEZING SYNDROME AMONG CHILDREN WITH RECURRENT BRONCHITIS.	MMP1 MMP12	2.83e-06	2	59	2	34459757
Pubmed	Matrix metalloproteinase-1 and matrix metalloproteinase-12 gene polymorphisms and the outcome of coronary artery disease.	MMP1 MMP12	2.83e-06	2	59	2	21606841
Pubmed	Matrix metalloproteinases.	MMP1 MMP12 MMP26	6.98e-06	22	59	3	10419448
Pubmed	Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population.	MMP1 MMP12	8.48e-06	3	59	2	20160424
Pubmed	Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer.	MMP1 MMP12	8.48e-06	3	59	2	16311244
Pubmed	Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis.	MMP1 MMP12	8.48e-06	3	59	2	19321798
Pubmed	Association of matrix metalloprotease 1, 3, and 12 polymorphisms with rheumatic heart disease in a Chinese Han population.	MMP1 MMP12	8.48e-06	3	59	2	29458338
Pubmed	Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke: A Mendelian Randomization Study.	MMP1 MMP12	8.48e-06	3	59	2	33902302
Pubmed	[Polymorphism in promoter regions of matrix metalloproteinases (MMP1, MMP9, and MMP12) in chronic obstructive pulmonary disease patients].	MMP1 MMP12	8.48e-06	3	59	2	18619044
Pubmed	Matrix metalloproteinase expression by human alveolar macrophages in relation to emphysema.	MMP1 MMP12	8.48e-06	3	59	2	18259971
Pubmed	MMP-1(-1607G) polymorphism as a risk factor for fibrosis after pulmonary tuberculosis in Taiwan.	MMP1 MMP12	8.48e-06	3	59	2	20392358
Pubmed	Anion exchanger 2 (AE2) binds to erythrocyte ankyrin and is colocalized with ankyrin along the basolateral plasma membrane of human gastric parietal cells.	ANK1 SLC4A2	8.48e-06	3	59	2	9587054
Pubmed	Matrix Metalloproteinase Genes (MMP1, MMP10, MMP12) on Chromosome 11q22 and the Risk of Non-Contact Anterior Cruciate Ligament Ruptures.	MMP1 MMP12	8.48e-06	3	59	2	32650441
Pubmed	Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency.	MMP1 MMP12	8.48e-06	3	59	2	19293200
Pubmed	[Study on matrix metalloproteinase 1, 9, 12 polymorphisms and susceptibility to chronic obstructive pulmonary disease among Han nationality in northern China].	MMP1 MMP12	8.48e-06	3	59	2	16676616
Pubmed	The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function.	MMP1 MMP12	8.48e-06	3	59	2	11875051
Pubmed	Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population.	MMP1 MMP12	8.48e-06	3	59	2	20078883
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF607 ZNF644 ZNF726 ZFP82 ZNF181	1.44e-05	181	59	5	37372979
Pubmed	Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancer.	MMP1 MMP12	1.69e-05	4	59	2	17000679
Pubmed	Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage.	MMP1 MMP12	1.69e-05	4	59	2	11546917
Pubmed	MMP expression in rheumatoid inflammation: the rs11568818 polymorphism is associated with MMP-7 expression at an extra-articular site.	MMP1 MMP12	1.69e-05	4	59	2	23343931
Pubmed	[Expression of genes for metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis].	MMP1 MMP12	1.69e-05	4	59	2	22117411
Pubmed	Matrix metalloproteinase genes on chromosome 11q22 and the risk of anterior cruciate ligament (ACL) rupture.	MMP1 MMP12	1.69e-05	4	59	2	21410539
Pubmed	All-trans retinoic acid induces arginase-1 and inducible nitric oxide synthase-producing dendritic cells with T cell inhibitory function.	EIF2AK4 ARG1	1.69e-05	4	59	2	24790153
Pubmed	Association between polymorphisms of matrix metalloproteinase 11 (MMP-11) and Kawasaki disease in the Korean population.	MMP12 MMP26	1.69e-05	4	59	2	20230842
Pubmed	Association of MMP1, MMP3, MMP9, and MMP12 polymorphisms with risk and clinical course of multiple sclerosis in a Polish population.	MMP1 MMP12	1.69e-05	4	59	2	19628284
Pubmed	Functional polymorphisms in matrix metalloproteinases -1, -3, -9 and -12 in relation to cervical artery dissection.	MMP1 MMP12	1.69e-05	4	59	2	19664242
Pubmed	Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population.	MMP1 MMP12	1.69e-05	4	59	2	29317790
Pubmed	Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema.	MMP1 MMP12	1.69e-05	4	59	2	23900981
Pubmed	Altered Expression Levels of MMP1, MMP9, MMP12, TIMP1, and IL-1β as a Risk Factor for the Elevated IOP and Optic Nerve Head Damage in the Primary Open-Angle Glaucoma Patients.	MMP1 MMP12	2.82e-05	5	59	2	26120586
Pubmed	Association of genotypes at the matrix metalloproteinase (MMP) loci with carotid IMT and presence of carotid and femoral atherosclerotic plaques.	MMP1 MMP12	2.82e-05	5	59	2	24043512
Pubmed	Expression of metalloproteinases 1, 2, 7, 9, and 12 in human cytotrophoblastic cells from normal and preeclamptic placentas.	MMP1 MMP12	2.82e-05	5	59	2	22936257
Pubmed	Matrix metalloproteinase haplotypes associated with coronary artery aneurysm formation in patients with Kawasaki disease.	MMP1 MMP12	2.82e-05	5	59	2	20827277
Pubmed	Variation in the matrix metalloproteinase-3, -7, -12 and -13 genes is associated with functional status in rheumatoid arthritis.	MMP1 MMP12	2.82e-05	5	59	2	17373931
Pubmed	Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.	TGFBR2 MMP1 MMP12	3.18e-05	36	59	3	20587546
Pubmed	Matrix metalloproteinase single-nucleotide polymorphisms and haplotypes predict breast cancer progression.	MMP1 MMP12	4.23e-05	6	59	2	18006768
Pubmed	TGF-β cytokine signaling promotes CD8+ T cell development and low-affinity CD4+ T cell homeostasis by regulation of interleukin-7 receptor α expression.	TGFBR2 GFI1	4.23e-05	6	59	2	23932572
Pubmed	Matrix metalloproteinase polymorphisms and bladder cancer risk.	MMP1 MMP12	4.23e-05	6	59	2	17178858
Pubmed	Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact.	MMP1 MMP12	4.23e-05	6	59	2	28122331
Pubmed	Single nucleotide polymorphisms in matrix metalloproteinase genes and lung cancer chemotherapy response and prognosis.	MMP1 MMP12	4.23e-05	6	59	2	19643940
Pubmed	Putative functional polymorphisms of MMP9 predict survival of NSCLC in a Chinese population.	MMP1 MMP12	4.23e-05	6	59	2	19132754
Pubmed	Matrix metalloproteinase polymorphisms are associated with bladder cancer invasiveness.	MMP1 MMP12	4.23e-05	6	59	2	17473191
Pubmed	Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors.	TGFBR2 MMP1	4.23e-05	6	59	2	19424605
Pubmed	Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3.	MMP1 MMP12	5.91e-05	7	59	2	8921407
Pubmed	Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3.	ANK1 SLC4A2	5.91e-05	7	59	2	2968981
Pubmed	Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation.	MMP1 MMP12	5.91e-05	7	59	2	10859319
Pubmed	Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation.	MMP1 MMP12	5.91e-05	7	59	2	11113146
Pubmed	Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinoma.	MMP1 MMP12	5.91e-05	7	59	2	17607721
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DNAJC16 SPEG ZNF644 FAM91A1 CLEC16A WDR47	6.61e-05	407	59	6	12693553
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	FCSK VPS13D DNAJC16 FAM91A1 PC CLEC16A SLC1A3	7.33e-05	606	59	7	36538041
Pubmed	TGF-beta1 induces the different expressions of lysyl oxidases and matrix metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after mechanical injury.	MMP1 MMP12	1.26e-04	10	59	2	23357697
Pubmed	The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.	USP21 WDR47	1.54e-04	11	59	2	27621083
Pubmed	Differential expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) during mouse gonad development.	MMP1 MMP12	2.18e-04	13	59	2	12815621
Pubmed	Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms.	MMP1 MMP12	2.18e-04	13	59	2	15944607
Pubmed	Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.	MMP1 MMP12	2.54e-04	14	59	2	16236725
Pubmed	Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families.	MMP1 MMP12	3.34e-04	16	59	2	20484597
Pubmed	Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis.	MMP12 ARG1	3.34e-04	16	59	2	25211233
Pubmed	Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.	MMP1 MMP12	3.34e-04	16	59	2	37701782
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF726 ZFP82	5.27e-04	20	59	2	7479878
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF726 ZFP82	5.27e-04	20	59	2	2542606
Pubmed	Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter.	MMP1 MMP12	5.27e-04	20	59	2	19590686
Pubmed	Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina.	TGFBR2 SLC1A3	5.82e-04	21	59	2	17559664
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP1 MMP12	6.39e-04	22	59	2	23421805
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	CELSR2 DNAJC16 GLG1 FAM91A1 PC CLEC16A SLC1A3 WDR47	6.51e-04	1139	59	8	36417873
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DNAJC16 FAM91A1 EIF2AK4 CLEC16A ZXDB SLC4A2	8.10e-04	650	59	6	38777146
Pubmed	TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.	GLG1 FLG2 ARG1	1.05e-03	117	59	3	36898370
Pubmed	Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism.	TGFBR2 MMP1	1.12e-03	29	59	2	23565059
Pubmed	A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.	MMP1 MMP12 ARG1	1.16e-03	121	59	3	19789190
Pubmed	Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth.	MMP1 MMP12	1.19e-03	30	59	2	22171010
Pubmed	Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.	TGFBR2 EIF2AK4 USP21	1.30e-03	126	59	3	24319055
Pubmed	FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability.	ZXDC ZXDB	1.36e-03	32	59	2	35813202
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	CELSR2 ADGRD2	1.44e-03	33	59	2	25713288
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	VPS13D ANK1 SPEG EIF2AK4 TAPBP	1.55e-03	497	59	5	36774506
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZXDC ZNF600 ZNF142 ZNF497 ZNF660 ZNF607 ZNF846 ZNF726 GFI1 ZFP82 ZNF181 ZXDB	6.94e-08	718	43	12	28
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP1 MMP12 MMP26	2.45e-05	24	43	3	891
GeneFamily	C1-set domain containing	CD1E TAPBP	4.48e-03	42	43	2	591
Disease	Hair Diseases	EIF2AK4 ARG1	1.02e-05	3	55	2	C0018500
Disease	Immune System Diseases	EIF2AK4 ARG1	7.12e-05	7	55	2	C0021053
Disease	argininate measurement	DNAJC16 ARG1	9.48e-05	8	55	2	EFO_0800055
Disease	Barrett's esophagus (is_implicated_in)	MMP1 MMP12	1.86e-04	11	55	2	DOID:9206 (is_implicated_in)
Disease	abdominal aortic aneurysm (is_implicated_in)	MMP1 MMP12	2.22e-04	12	55	2	DOID:7693 (is_implicated_in)
Disease	Amino Acid Metabolism, Inherited Disorders	EIF2AK4 ARG1	2.63e-04	13	55	2	C0750905
Disease	Amino Acid Metabolism, Inborn Errors	EIF2AK4 ARG1	2.63e-04	13	55	2	C0002514
Disease	thoracic aortic aneurysm (is_marker_for)	MMP1 MMP12	3.06e-04	14	55	2	DOID:14004 (is_marker_for)
Disease	Pulmonary Emphysema	TGFBR2 MMP12	4.56e-04	17	55	2	C0034067
Disease	Eye Abnormalities	TGFBR2 APAF1	4.56e-04	17	55	2	C0015393
Disease	esophagus adenocarcinoma (is_implicated_in)	MMP1 MMP12	7.00e-04	21	55	2	DOID:4914 (is_implicated_in)
Disease	arteriosclerosis (is_marker_for)	TGFBR2 PAPPA	1.34e-03	29	55	2	DOID:2349 (is_marker_for)
Disease	Myopathy	EIF2AK4 ARG1	1.44e-03	30	55	2	C0026848
Disease	arteriosclerosis (is_implicated_in)	MMP1 MMP12	1.53e-03	31	55	2	DOID:2349 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ATHGLCHLLGFTHGT	YBEY	116	P58557
IHTSGLLGEIHTGHH	APAF1	826	O14727
NISAGSLGSLLGHHH	SLC4A2	441	P04920
SLGSLLGHHHGQGAE	SLC4A2	446	P04920
HISGVSLAAHLSHSG	EIF2AK4	381	Q9P2K8
TAGHTPLHIAAREGH	ANK1	501	P16157
LHHPGDSHSGRVSFL	COMMD5	11	Q9GZQ3
GTELTGHLVPHHDGL	CELSR2	76	Q9HCU4
TPEGLRHGTRLHTHL	AOC1	491	P19801
HSLAIGSISGHARVH	ARG1	101	P05089
ATHEIGHSLGLQHSG	MMP26	206	Q9NRE1
HHSREGLVLGHCISR	MROH7	181	Q68CQ1
LQSIVVGSLHHTGHL	ADARB2	581	Q9NS39
AVHEIGHSLGLGHSS	MMP12	216	P39900
SIVHERHGTIHGQTG	FLG2	1761	Q5D862
RHGTIHGQTGDTTRH	FLG2	1766	Q5D862
GAGLVHHATRAGHLD	ESPNL	36	Q6ZVH7
KVHLIGHSLGAHLAG	PNLIPRP3	161	Q17RR3
TPHGLEVHVRRSHSG	GFI1	266	Q99684
LRITHSNAGHLRGHG	GPSM1	576	Q86YR5
LTLGHTTGSGDLGHV	KIAA2026	1371	Q5HYC2
THSAVLIQGHGLHGI	FAM91A1	596	Q658Y4
LIQGHGLHGIGETVH	FAM91A1	601	Q658Y4
LAHHLGAHSTPSILG	DNAJC16	206	Q9Y2G8
LGLTPLHHASREGHV	ANKRD65	301	E5RJM6
TLTGHDGGDCRHLRH	PAPPA	431	Q13219
RVNGKVSGHLHVGHT	NID2	531	Q14112
HTRLHGSPGHAFTLV	FCSK	426	Q8N0W3
GEIEHHCSGLHRKGR	GLG1	446	Q92896
RVKHSSLGGHDLIIH	CD1E	286	P15812
IGGGIIHQHELIHGS	GNE	546	Q9Y223
GDSLGAGIVEHLSRH	SLC1A3	486	P43003
VGTHGHSDHIGNLGL	MBLAC1	111	A4D2B0
IRAISLGHGHILVGT	EML5	961	Q05BV3
GLSLVNGHVGHSHHL	SLC39A12	476	Q504Y0
ILHDTHLSIGHGGRT	KRBA2	196	Q6ZNG9
QESLTLHRSGGHIAH	AANAT	106	Q16613
DHSRHHHGSSIAGGL	NBR1	871	Q14596
AAHELGHSLGLSHST	MMP1	216	P03956
GSSLARGIAHLHSDH	TGFBR2	351	P37173
QHRHAGLSGVTVIHS	ADGRD2	516	Q7Z7M1
ILANGGSLSHHHGVG	AGPS	606	O00116
GGHGKTSRNIHSLDH	CLEC16A	11	Q2KHT3
QGLHALSGHTGHILA	WDR47	746	O94967
TRAEHLKGHSITHLG	ZXDB	496	P98169
RGSSGLAHHRLSHTG	ZNF497	396	Q6ZNH5
AHHTLLLGSGHVGLR	USP21	201	Q9UK80
SNSSHLIGHGRIHSG	ZNF846	236	Q147U1
RAEHLKGHSITHLGT	ZXDC	401	Q2QGD7
GGLHSLHIAHVGSED	SPEG	1116	Q15772
ALRHHSDGSVSLSGH	TAPBP	351	O15533
SGKSHLIRHQGIHSG	ZNF660	116	Q6AZW8
VHGRLTRHQGIHSGK	ZNF607	376	Q96SK3
IHLGSSHSSIHGIHG	TTC41P	1081	Q6P2S7
SHSSIHGIHGILHLL	TTC41P	1086	Q6P2S7
DHTGRIRVHGIGGGH	MRPL2	86	Q5T653
VGLSNHVRGHLHRAG	ZNF644	976	Q9H582
SQFGHLTTHRIIHTG	ZNF726	351	A6NNF4
CGSGLRVHHKLHTGE	ZFP82	321	Q8N141
LHNTHLSIGHGGRTR	ZBED9	311	Q6R2W3
QLVLDHHVKGHGGTR	ZNF142	1436	P52746
GSDSHLKQHTGLHTG	ZNF600	676	Q6ZNG1
LPLHIHTHDTSGAGV	PC	766	P11498
HGSSLTRHLISHSGE	ZNF181	276	Q2M3W8
TSGEHLVAGIHGLAH	VPS13D	4141	Q5THJ4