Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	semaphorin receptor activity	PLXNA3 PLXND1 PLXNC1	2.16e-05	12	94	3	GO:0017154
GeneOntologyBiologicalProcess	regulation of cell size	PLXNA3 RTN4R BCL11A SLC12A4 MEGF8 SLIT1 PLEK IQGAP3	1.20e-05	225	98	8	GO:0008361
GeneOntologyBiologicalProcess	regulation of axonogenesis	PLXNA3 RTN4R BCL11A PLXND1 MEGF8 PLXNC1 SLIT1	3.68e-05	192	98	7	GO:0050770
GeneOntologyBiologicalProcess	regulation of axon extension involved in axon guidance	PLXNA3 MEGF8 SLIT1	6.74e-05	17	98	3	GO:0048841
GeneOntologyBiologicalProcess	negative chemotaxis	PLXNA3 RTN4R ITGB3 SLIT1	1.01e-04	51	98	4	GO:0050919
GeneOntologyBiologicalProcess	axon extension involved in axon guidance	PLXNA3 MEGF8 SLIT1	1.50e-04	22	98	3	GO:0048846
GeneOntologyBiologicalProcess	neuron projection extension involved in neuron projection guidance	PLXNA3 MEGF8 SLIT1	1.50e-04	22	98	3	GO:1902284
GeneOntologyBiologicalProcess	regulation of anatomical structure size	PLXNA3 RTN4R BCL11A SPTBN5 SLC12A4 MEGF8 SLIT1 FGB PLEK SERPINF2 IQGAP3	1.69e-04	618	98	11	GO:0090066
GeneOntologyBiologicalProcess	regulation of cellular component size	PLXNA3 RTN4R BCL11A SPTBN5 SLC12A4 MEGF8 SLIT1 PLEK IQGAP3	1.95e-04	426	98	9	GO:0032535
GeneOntologyBiologicalProcess	positive regulation of axonogenesis	PLXNA3 BCL11A PLXND1 MEGF8 PLXNC1	2.13e-04	114	98	5	GO:0050772
GeneOntologyBiologicalProcess	negative regulation of axonogenesis	PLXNA3 RTN4R BCL11A SLIT1	2.16e-04	62	98	4	GO:0050771
GeneOntologyBiologicalProcess	blood coagulation	HGFAC VWF ITGB3 HPS4 FGB PLEK SERPINF2	2.43e-04	260	98	7	GO:0007596
GeneOntologyBiologicalProcess	zymogen activation	HGFAC MASP1 FGB SERPINF2	2.60e-04	65	98	4	GO:0031638
GeneOntologyBiologicalProcess	coagulation	HGFAC VWF ITGB3 HPS4 FGB PLEK SERPINF2	2.79e-04	266	98	7	GO:0050817
GeneOntologyBiologicalProcess	regulation of extent of cell growth	PLXNA3 RTN4R BCL11A MEGF8 SLIT1	2.92e-04	122	98	5	GO:0061387
GeneOntologyBiologicalProcess	hemostasis	HGFAC VWF ITGB3 HPS4 FGB PLEK SERPINF2	2.92e-04	268	98	7	GO:0007599
GeneOntologyBiologicalProcess	axonogenesis	PLXNA3 MYCBP2 SZT2 RTN4R EVX1 BCL11A PLXND1 MEGF8 PLXNC1 SLIT1	3.60e-04	566	98	10	GO:0007409
GeneOntologyCellularComponent	semaphorin receptor complex	PLXNA3 PLXND1 PLXNC1	3.02e-05	13	101	3	GO:0002116
HumanPheno	Persistent bleeding after trauma	VWF ITGB3 FGB SERPINF2	2.36e-05	28	32	4	HP:0001934
Domain	EGF_1	HGFAC LAMB4 MASP1 SSPOP LRP1B ITGB3 MEGF8 SLIT1 DLL3 NTN5 LRP5	6.30e-08	255	94	11	PS00022
Domain	EGF_2	HGFAC LAMB4 MASP1 SSPOP LRP1B ITGB3 MEGF8 SLIT1 DLL3 NTN5 LRP5	9.31e-08	265	94	11	PS01186
Domain	PSI	PLXNA3 PLXND1 ITGB3 MEGF8 PLXNC1	2.70e-06	44	94	5	IPR016201
Domain	PSI	PLXNA3 PLXND1 ITGB3 MEGF8 PLXNC1	3.38e-06	46	94	5	SM00423
Domain	EGF-like_CS	HGFAC LAMB4 MASP1 LRP1B ITGB3 MEGF8 SLIT1 DLL3 LRP5	6.69e-06	261	94	9	IPR013032
Domain	Plexin_cytopl	PLXNA3 PLXND1 PLXNC1	1.01e-05	9	94	3	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNA3 PLXND1 PLXNC1	1.01e-05	9	94	3	IPR013548
Domain	Plexin	PLXNA3 PLXND1 PLXNC1	1.01e-05	9	94	3	IPR031148
Domain	PSI	PLXNA3 PLXND1 MEGF8 PLXNC1	1.94e-05	32	94	4	PF01437
Domain	Plexin_repeat	PLXNA3 PLXND1 MEGF8 PLXNC1	1.94e-05	32	94	4	IPR002165
Domain	EGF_3	HGFAC MASP1 SSPOP LRP1B MEGF8 SLIT1 DLL3 LRP5	2.45e-05	235	94	8	PS50026
Domain	EGF-like_Ca-bd_dom	MASP1 LRP1B MEGF8 SLIT1 DLL3 LRP5	3.83e-05	124	94	6	IPR001881
Domain	EGF	HGFAC LRP1B ITGB3 SLIT1 DLL3 LRP5	4.19e-05	126	94	6	PF00008
Domain	CTCK_1	VWF SSPOP SLIT1	9.54e-05	18	94	3	PS01185
Domain	-	KLHDC9 MEGF8 KBTBD11 KLHL34	9.88e-05	48	94	4	2.120.10.80
Domain	VWC_out	VWF CRIM1 SSPOP	1.13e-04	19	94	3	SM00215
Domain	EGF_CA	MASP1 LRP1B MEGF8 SLIT1 LRP5	1.43e-04	99	94	5	PS01187
Domain	Kelch-typ_b-propeller	KLHDC9 MEGF8 KBTBD11 KLHL34	1.69e-04	55	94	4	IPR015915
Domain	Cys_knot_C	VWF SSPOP SLIT1	2.62e-04	25	94	3	IPR006207
Domain	CTCK_2	VWF SSPOP SLIT1	2.62e-04	25	94	3	PS01225
Domain	EGF-like_dom	HGFAC MASP1 LRP1B MEGF8 SLIT1 DLL3 LRP5	2.63e-04	249	94	7	IPR000742
Domain	IPT	PLXNA3 PLXND1 PLXNC1	3.31e-04	27	94	3	SM00429
Domain	EGF_CA	MASP1 LRP1B MEGF8 SLIT1 DLL3	3.78e-04	122	94	5	SM00179
Domain	EGF_LAM_2	LAMB4 MEGF8 NTN5	4.54e-04	30	94	3	PS50027
Domain	EGF_LAM_1	LAMB4 MEGF8 NTN5	4.54e-04	30	94	3	PS01248
Domain	TIG	PLXNA3 PLXND1 PLXNC1	5.01e-04	31	94	3	PF01833
Domain	Sema	PLXNA3 PLXND1 PLXNC1	5.01e-04	31	94	3	SM00630
Domain	Semap_dom	PLXNA3 PLXND1 PLXNC1	5.01e-04	31	94	3	IPR001627
Domain	Sema	PLXNA3 PLXND1 PLXNC1	5.01e-04	31	94	3	PF01403
Domain	SEMA	PLXNA3 PLXND1 PLXNC1	5.01e-04	31	94	3	PS51004
Domain	TLV_coat	ERVV-2 ERVV-1	5.18e-04	7	94	2	PF00429
Domain	IPT	PLXNA3 PLXND1 PLXNC1	5.51e-04	32	94	3	IPR002909
Domain	TLV/ENV_coat_polyprotein	ERVV-2 ERVV-1	6.88e-04	8	94	2	IPR018154
Domain	Laminin_EGF	LAMB4 MEGF8 NTN5	7.19e-04	35	94	3	PF00053
Domain	EGF_Lam	LAMB4 MEGF8 NTN5	7.19e-04	35	94	3	SM00180
Domain	VWFC_1	VWF CRIM1 SSPOP	7.82e-04	36	94	3	PS01208
Domain	Integin_beta_N	ITGB3 MEGF8	8.82e-04	9	94	2	IPR033760
Domain	PSI_integrin	ITGB3 MEGF8	8.82e-04	9	94	2	PF17205
Domain	VWC	VWF CRIM1 SSPOP	9.17e-04	38	94	3	SM00214
Domain	VWFC_2	VWF CRIM1 SSPOP	9.17e-04	38	94	3	PS50184
Domain	Laminin_EGF	LAMB4 MEGF8 NTN5	9.17e-04	38	94	3	IPR002049
Domain	Rho_GTPase_activation_prot	PLXNA3 PLXND1 PLXNC1 IQGAP3	1.02e-03	88	94	4	IPR008936
Domain	LDLR_class-A_CS	SSPOP LRP1B LRP5	1.07e-03	40	94	3	IPR023415
Domain	Growth_fac_rcpt_	CRIM1 LRP1B MEGF8 SLIT1 DLL3	1.15e-03	156	94	5	IPR009030
Domain	EGF	HGFAC LRP1B MEGF8 SLIT1 DLL3 LRP5	1.21e-03	235	94	6	SM00181
Domain	VWF_dom	VWF CRIM1 SSPOP	1.23e-03	42	94	3	IPR001007
Domain	EGF_Ca-bd_CS	MASP1 LRP1B MEGF8 SLIT1	1.46e-03	97	94	4	IPR018097
Domain	Ldl_recept_a	SSPOP LRP1B LRP5	1.50e-03	45	94	3	PF00057
Domain	TIL	VWF SSPOP	1.60e-03	12	94	2	PF01826
Domain	C8	VWF SSPOP	1.60e-03	12	94	2	PF08742
Domain	-	SSPOP LRP1B LRP5	1.60e-03	46	94	3	4.10.400.10
Domain	LDLRA_1	SSPOP LRP1B LRP5	1.81e-03	48	94	3	PS01209
Domain	TRYPSIN_HIS	HGFAC MASP1 KLK6 PRSS57	1.82e-03	103	94	4	IPR018114
Domain	Ig_E-set	PLXNA3 MYCBP2 PLXND1 PLXNC1	1.88e-03	104	94	4	IPR014756
Domain	Unchr_dom_Cys-rich	VWF SSPOP	1.89e-03	13	94	2	IPR014853
Domain	C8	VWF SSPOP	1.89e-03	13	94	2	SM00832
Domain	LDLRA_2	SSPOP LRP1B LRP5	1.92e-03	49	94	3	PS50068
Domain	LDrepeatLR_classA_rpt	SSPOP LRP1B LRP5	1.92e-03	49	94	3	IPR002172
Domain	LDLa	SSPOP LRP1B LRP5	1.92e-03	49	94	3	SM00192
Domain	TRYPSIN_SER	HGFAC MASP1 KLK6 PRSS57	2.02e-03	106	94	4	PS00135
Domain	EGF-type_Asp/Asn_hydroxyl_site	MASP1 LRP1B MEGF8 SLIT1	2.02e-03	106	94	4	IPR000152
Domain	TRYPSIN_HIS	HGFAC MASP1 KLK6 PRSS57	2.09e-03	107	94	4	PS00134
Domain	TIL_dom	VWF SSPOP	2.19e-03	14	94	2	IPR002919
Domain	Ldl_recept_b	LRP1B LRP5	2.19e-03	14	94	2	PF00058
Domain	LDLRB	LRP1B LRP5	2.19e-03	14	94	2	PS51120
Domain	LY	LRP1B LRP5	2.52e-03	15	94	2	SM00135
Domain	LDLR_classB_rpt	LRP1B LRP5	2.52e-03	15	94	2	IPR000033
Domain	Peptidase_S1A	HGFAC MASP1 KLK6 PRSS57	2.55e-03	113	94	4	IPR001314
Domain	TRYPSIN_DOM	HGFAC MASP1 KLK6 PRSS57	2.72e-03	115	94	4	PS50240
Domain	VWD	VWF SSPOP	2.87e-03	16	94	2	SM00216
Domain	VWF_type-D	VWF SSPOP	2.87e-03	16	94	2	IPR001846
Domain	-	PLXNA3 IQGAP3	2.87e-03	16	94	2	1.10.506.10
Domain	VWFD	VWF SSPOP	2.87e-03	16	94	2	PS51233
Domain	VWD	VWF SSPOP	2.87e-03	16	94	2	PF00094
Domain	Tryp_SPc	HGFAC MASP1 KLK6 PRSS57	2.89e-03	117	94	4	SM00020
Domain	NAD/diacylglycerol_kinase	SPHK2 NADK2	3.24e-03	17	94	2	IPR016064
Domain	Trypsin	HGFAC MASP1 KLK6 PRSS57	3.26e-03	121	94	4	PF00089
Domain	Trypsin_dom	HGFAC MASP1 KLK6 PRSS57	3.26e-03	121	94	4	IPR001254
Domain	Gal_Oxase/kelch_b-propeller	KLHDC9 MEGF8 KBTBD11	3.27e-03	59	94	3	IPR011043
Domain	EGF_extracell	LRP1B ITGB3 DLL3	3.43e-03	60	94	3	IPR013111
Domain	EGF_2	LRP1B ITGB3 DLL3	3.43e-03	60	94	3	PF07974
Domain	Peptidase_S1_PA	HGFAC MASP1 KLK6 PRSS57	3.46e-03	123	94	4	IPR009003
Domain	ZF_RING_1	RNF169 MYCBP2 TRIM65 TRIM28 UBR3 PDZRN3	3.52e-03	291	94	6	PS00518
Domain	RasGAP_dom	PLXNA3 IQGAP3	3.64e-03	18	94	2	IPR001936
Domain	ZF_RING_2	RNF169 MYCBP2 TRIM65 TRIM28 UBR3 PDZRN3	3.95e-03	298	94	6	PS50089
Domain	RCC1	MYCBP2 IBTK	4.49e-03	20	94	2	PF00415
Domain	RCC1_1	MYCBP2 IBTK	4.95e-03	21	94	2	PS00625
Domain	RCC1_2	MYCBP2 IBTK	4.95e-03	21	94	2	PS00626
Domain	RCC1_3	MYCBP2 IBTK	4.95e-03	21	94	2	PS50012
Pathway	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	VWF ITGB3 FGB	4.48e-05	15	67	3	M12101
Pathway	REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	VWF ITGB3 FGB	4.48e-05	15	67	3	M1262
Pathway	REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	VWF ITGB3 FGB	4.48e-05	15	67	3	MM14959
Pathway	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	VWF ITGB3 FGB	4.48e-05	15	67	3	MM14961
Pathway	WP_BLOOD_CLOTTING_CASCADE	VWF FGB SERPINF2	1.48e-04	22	67	3	M39480
Pathway	WP_COMPLEMENT_AND_COAGULATION_CASCADES	MASP1 VWF FGB SERPINF2	1.63e-04	58	67	4	M39649
Pathway	WP_BLOOD_CLOTTING_CASCADE	VWF FGB SERPINF2	1.70e-04	23	67	3	MM15936
Pathway	WP_DENGUE2_INTERACTIONS_WITH_COMPLEMENT_AND_COAGULATION_CASCADES	MASP1 VWF FGB SERPINF2	1.74e-04	59	67	4	M48343
Pathway	REACTOME_INTEGRIN_SIGNALING	VWF ITGB3 FGB	2.77e-04	27	67	3	M760
Pathway	REACTOME_INTEGRIN_SIGNALING	VWF ITGB3 FGB	3.09e-04	28	67	3	MM14958
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	MASP1 VWF FGB SERPINF2	3.19e-04	69	67	4	M16894
Pathway	REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2	VWF ITGB3 FGB PLEK SERPINF2	3.77e-04	130	67	5	MM15455
Pathway	REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2	VWF ITGB3 FGB PLEK SERPINF2	4.05e-04	132	67	5	M724
Pathway	REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION	VWF ITGB3 FGB	7.69e-04	38	67	3	MM15456
Pathway	REACTOME_MAP2K_AND_MAPK_ACTIVATION	VWF ITGB3 FGB	8.30e-04	39	67	3	MM15272
Pathway	REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION	VWF ITGB3 FGB	8.30e-04	39	67	3	M10735
Pathway	REACTOME_MAP2K_AND_MAPK_ACTIVATION	VWF ITGB3 FGB	8.94e-04	40	67	3	M27557
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COAGULATION_CASCADE_FIBRINOGEN_TO_FIBRIN	MASP1 FGB	9.77e-04	10	67	2	M47879
Pubmed	Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo.	VWF ITGB3 FGB	2.37e-07	5	101	3	16824188
Pubmed	The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to IIb/IIIa antagonists.	VWF ITGB3 FGB	2.81e-06	10	101	3	12082590
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PLXNA3 SPHK2 MYCBP2 SZT2 PLXND1 ZBED3 SLC12A4 MEGF8 TRIM28 KBTBD11 LRP5 SAC3D1 CACNA1H IQGAP3	3.86e-06	1105	101	14	35748872
Pubmed	Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.	PLXNA3 PLXND1 PLXNC1	5.13e-06	12	101	3	21270798
Pubmed	Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.	PLXNA3 PLXND1 PLXNC1	6.66e-06	13	101	3	10520995
Pubmed	Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane.	VWF ITGB3	8.35e-06	2	101	2	22134168
Pubmed	Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.	KIF7 UBR3	8.35e-06	2	101	2	27195754
Pubmed	The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation.	ITGB3 FGB	8.35e-06	2	101	2	20538554
Pubmed	Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.	ERVV-2 ERVV-1	8.35e-06	2	101	2	18826608
Pubmed	The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.	EGLN3 KIF1B	8.35e-06	2	101	2	18334619
Pubmed	Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.	ERVV-2 ERVV-1	8.35e-06	2	101	2	23555306
Pubmed	Beta3 integrin haplotype influences gene regulation and plasma von Willebrand factor activity.	VWF ITGB3	8.35e-06	2	101	2	18045606
Pubmed	p130Cas: a versatile scaffold in signaling networks.	VWF ITGB3 FGB	8.45e-06	14	101	3	16581250
Pubmed	Integrins and Src: dynamic duo of adhesion signaling.	VWF ITGB3 FGB	8.45e-06	14	101	3	16005629
Pubmed	Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors.	KLK6 FGB SERPINF2	8.45e-06	14	101	3	12878203
Pubmed	TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.	PLXNA3 PLXND1 PLXNC1 SLIT1	1.09e-05	47	101	4	35462405
Pubmed	Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.	PLXNA3 PLXND1 PLXNC1	1.57e-05	17	101	3	11683995
Pubmed	Semaphorin signaling facilitates cleft formation in the developing salivary gland.	PLXNA3 PLXND1 PLXNC1	1.57e-05	17	101	3	17626059
Pubmed	An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.	PLXNA3 PLXND1 PLXNC1 NTN5	1.63e-05	52	101	4	26633812
Pubmed	Potential role for a specialized β3 integrin-based structure on osteocyte processes in bone mechanosensation.	ITGB3 CACNA1H	2.50e-05	3	101	2	29087614
Pubmed	USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3.	EGLN3 KIF1B	2.50e-05	3	101	2	34112167
Pubmed	Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin alpha(IIb)beta(3) and myosin light chain.	VWF ITGB3	2.50e-05	3	101	2	19765213
Pubmed	Solid-phase von Willebrand factor contains a conformationally active RGD motif that mediates endothelial cell adhesion through the alpha v beta 3 receptor.	VWF ITGB3	2.50e-05	3	101	2	7505120
Pubmed	Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3.	VWF FGB	2.50e-05	3	101	2	9351824
Pubmed	Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress.	VWF ITGB3	2.50e-05	3	101	2	18927433
Pubmed	Platelet adhesion receptors do not modulate infarct volume after a photochemically induced stroke in mice.	VWF ITGB3	2.50e-05	3	101	2	17996853
Pubmed	Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor.	VWF ITGB3	2.50e-05	3	101	2	30305279
Pubmed	The Commensal Microbiota Enhances ADP-Triggered Integrin αIIbβ3 Activation and von Willebrand Factor-Mediated Platelet Deposition to Type I Collagen.	VWF ITGB3	2.50e-05	3	101	2	32998468
Pubmed	Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.	PLXNA3 CRIM1 PLXND1 PLXNC1 SLIT1	3.46e-05	126	101	5	16284245
Pubmed	Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa.	VWF ITGB3	4.99e-05	4	101	2	18487513
Pubmed	Analysis of plasminogen activator inhibitor-1, integrin beta3, beta fibrinogen, and methylenetetrahydrofolate reductase polymorphisms in Iranian women with recurrent pregnancy loss.	ITGB3 FGB	4.99e-05	4	101	2	21241403
Pubmed	Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins.	VWF ITGB3	4.99e-05	4	101	2	11071623
Pubmed	Recombinant human ZP3-induced sperm acrosome reaction: evidence for the involvement of T- and L-type voltage-gated calcium channels.	ZP2 CACNA1H	4.99e-05	4	101	2	20394732
Pubmed	Immunocytochemical localization of peroxisomal proteins in human liver and kidney.	ACAA1 AGXT	4.99e-05	4	101	2	9053548
Pubmed	Osteopetrosis with micro-lacunar resorption because of defective integrin organization.	ITGB3 PLEK	4.99e-05	4	101	2	19546854
Pubmed	Intercellular calcium communication regulates platelet aggregation and thrombus growth.	VWF ITGB3	4.99e-05	4	101	2	12668663
Pubmed	The VWF/LRP4/αVβ3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells.	VWF ITGB3	4.99e-05	4	101	2	33576766
Pubmed	ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.	VWF ITGB3	4.99e-05	4	101	2	17003372
Pubmed	Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3.	VWF ITGB3	4.99e-05	4	101	2	8918453
Pubmed	Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.	PLXNA3 PLXNC1 SLIT1	7.39e-05	28	101	3	18617019
Pubmed	[Associations of hemostasis factors genes with early development of ischemic heart disease and manifestation of myocardial infarction in young age].	ITGB3 FGB	8.30e-05	5	101	2	16353042
Pubmed	Different requirement for Rnd GTPases of R-Ras GAP activity of Plexin-C1 and Plexin-D1.	PLXND1 PLXNC1	8.30e-05	5	101	2	19136556
Pubmed	Platelet polymorphisms: frequency distribution and association with coronary artery disease in an Indian population.	ITGB3 FGB	8.30e-05	5	101	2	21034162
Pubmed	Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse.	VWF FGB	8.30e-05	5	101	2	11891199
Pubmed	Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor.	VWF ITGB3	8.30e-05	5	101	2	19036705
Pubmed	Inflammation induces hemorrhage in thrombocytopenia.	VWF ITGB3	8.30e-05	5	101	2	18256319
Pubmed	Absence of association between polymorphisms in the hemostatic factor pathway genes and carotid intimal medial thickness: the Framingham Heart Study.	ITGB3 FGB	8.30e-05	5	101	2	14963283
Pubmed	Analysis of inherited thrombophilic mutations and natural anticoagulant deficiency in patients with idiopathic portal hypertension.	ITGB3 FGB	8.30e-05	5	101	2	18685811
Pubmed	hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis.	MRPL12 NOA1	8.30e-05	5	101	2	19103604
Pubmed	Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways.	ITGB3 FGB	8.30e-05	5	101	2	10605720
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	HGFAC PLXND1 ITGB3 MEGF8 FGB SERPINF2	1.08e-04	257	101	6	16335952
Pubmed	Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression.	VWF ITGB3	1.24e-04	6	101	2	19332769
Pubmed	Connection between genetically determined blood coagulation factors and haemorheology.	ITGB3 FGB	1.24e-04	6	101	2	18503143
Pubmed	Spectrum and prevalence of prothrombotic single nucleotide polymorphism profiles in the Greek Cypriot population.	ITGB3 FGB	1.24e-04	6	101	2	12518110
Pubmed	Mutations and polymorphisms in genes affecting haemostasis components in children with thromboembolic events.	ITGB3 FGB	1.24e-04	6	101	2	17230042
Pubmed	Comparison of thrombophilic gene mutations among patients experiencing recurrent miscarriage and deep vein thrombosis.	ITGB3 FGB	1.24e-04	6	101	2	18803625
Pubmed	Positional cloning of a global regulator of anterior-posterior patterning in mice.	EVX1 MEOX1	1.24e-04	6	101	2	8805699
Pubmed	Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition.	NRIP1 HDAC5	1.24e-04	6	101	2	15060175
Pubmed	Role of thrombophilic gene polymorphisms in branch retinal vein occlusion.	ITGB3 FGB	1.24e-04	6	101	2	16157382
Pubmed	Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.	ERVV-2 ERVV-1	1.24e-04	6	101	2	23085571
Pubmed	Prothrombotic polymorphisms, mutations, and their association with pediatric non-cardioembolic stroke in Asian-Indian patients.	ITGB3 FGB	1.74e-04	7	101	2	18836720
Pubmed	Mutations and polymorphisms in genes affecting hemostasis proteins and homocysteine metabolism in children with arterial ischemic stroke.	ITGB3 FGB	1.74e-04	7	101	2	16567932
Pubmed	Polymorphisms in prothrombotic genes and their impact on ischemic stroke in a Sardinian population.	ITGB3 FGB	1.74e-04	7	101	2	15968394
Pubmed	Multiple thrombophilic gene mutations rather than specific gene mutations are risk factors for recurrent miscarriage.	ITGB3 FGB	1.74e-04	7	101	2	16635210
Pubmed	Early pregnancy loss in celiac women: The role of genetic markers of thrombophilia.	ITGB3 FGB	1.74e-04	7	101	2	19395327
Pubmed	Mice lacking factor VII develop normally but suffer fatal perinatal bleeding.	VWF FGB	1.74e-04	7	101	2	9384381
Pubmed	Thrombophilic gene polymorphisms are risk factors for unexplained infertility.	ITGB3 FGB	1.74e-04	7	101	2	18930220
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	MYCBP2 TRIM65 TRIM28 UBR3	1.74e-04	95	101	4	29643511
Pubmed	The expression of plexins during mouse embryogenesis.	PLXNA3 PLXNC1	2.31e-04	8	101	2	15661641
Pubmed	Syncytins expressed in human placental trophoblast.	ERVV-2 ERVV-1	2.31e-04	8	101	2	33504453
Pubmed	Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release.	ITGB3 FGB	2.31e-04	8	101	2	27221710
Pubmed	Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain.	NRIP1 TRIM28	2.31e-04	8	101	2	9774463
Pubmed	Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.	MEGF8 SLIT1	2.97e-04	9	101	2	9693030
Pubmed	Impact of genetic polymorphisms on platelet function and aspirin resistance.	ITGB3 FGB	2.97e-04	9	101	2	19923980
Pubmed	Candidate genetic markers and the risk of restenosis after coronary angioplasty.	ITGB3 FGB	2.97e-04	9	101	2	12899665
Pubmed	LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE-carrying lipoproteins.	LRP1B FGB	2.97e-04	9	101	2	21420681
Pubmed	The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries.	MEOX1 DLL3	3.70e-04	10	101	2	9662403
Pubmed	A prospective case-control study analyzes 12 thrombophilic gene mutations in Turkish couples with recurrent pregnancy loss.	ITGB3 FGB	3.70e-04	10	101	2	19906129
Pubmed	Vascular at-risk genotypes and disease severity in Lebanese sickle cell disease patients.	ITGB3 FGB	3.70e-04	10	101	2	20425806
Pubmed	Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects.	VWF PLXND1	3.70e-04	10	101	2	18992737
Pubmed	Prevalence of prothrombotic polymorphisms in Greece.	ITGB3 FGB	3.70e-04	10	101	2	19072566
Pubmed	Hemostatic gene polymorphisms in young Sardinian with non-fatal acute myocardial infarction.	VWF FGB	3.70e-04	10	101	2	20036902
Pubmed	A comprehensive analysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel disease: data from Turkey.	ITGB3 FGB	3.70e-04	10	101	2	17111197
Pubmed	Genetics of early mammalian folliculogenesis.	ZP2 NOBOX	4.51e-04	11	101	2	16416028
Pubmed	Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.	PDE3B HDAC5	4.51e-04	11	101	2	22649097
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP1B LRP5	4.51e-04	11	101	2	24639464
Pubmed	Defects in somite formation in lunatic fringe-deficient mice.	MEOX1 DLL3	4.51e-04	11	101	2	9690472
Pubmed	Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.	PLXNA3 PLXND1	5.41e-04	12	101	2	25839327
Pubmed	Potential thrombophilic mutations/polymorphisms in patients with no flow-limiting stenosis after myocardial infarction.	ITGB3 FGB	5.41e-04	12	101	2	12514663
Pubmed	Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy.	KIF1B TRIM28	5.41e-04	12	101	2	23569248
Pubmed	A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11.	VWF ITGB3	5.41e-04	12	101	2	8986815
Pubmed	Genetic influences on lipid metabolism trait variability within the Stanislas Cohort.	ITGB3 FGB	5.41e-04	12	101	2	11714857
Pubmed	Nolz1 expression is required in dopaminergic axon guidance and striatal innervation.	PLXND1 PLXNC1 SLIT1	5.59e-04	55	101	3	32561725
Pubmed	Prothrombotic genetic variants and atherosclerosis in patients with cerebral ischemia of arterial origin.	VWF FGB	6.38e-04	13	101	2	18848323
Pubmed	Genetic influences on blood pressure within the Stanislas Cohort.	ITGB3 FGB	6.38e-04	13	101	2	15076187
Pubmed	Genetic cardiovascular risk factors and age-related macular degeneration.	ITGB3 FGB	6.38e-04	13	101	2	19860767
Pubmed	The mouse rib-vertebrae mutation disrupts anterior-posterior somite patterning and genetically interacts with a Delta1 null allele.	MEOX1 DLL3	6.38e-04	13	101	2	10906448
Pubmed	PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition.	ZP2 NOBOX	6.38e-04	13	101	2	32558204
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	VWF ACAA1 KIF1B ITGB3 TRIM28 GSDMD	6.55e-04	360	101	6	33111431
Pubmed	Gene polymorphisms in association with emerging cardiovascular risk markers in adult women.	ITGB3 FGB	7.43e-04	14	101	2	20078877
GeneFamily	Plexins	PLXNA3 PLXND1 PLXNC1	2.73e-06	9	59	3	683
GeneFamily	Low density lipoprotein receptors	LRP1B LRP5	7.98e-04	13	59	2	634
GeneFamily	Proteases, serine	MASP1 KLK6 PRSS57	1.14e-03	63	59	3	738
Coexpression	NABA_MATRISOME	PLXNA3 HGFAC EGLN3 LAMB4 MASP1 VWF CRIM1 ADAMTS8 PLXND1 ZP2 SSPOP CD209 MEGF8 PLXNC1 SLIT1 NTN5 FGB SERPINF2	5.05e-08	1026	99	18	M5889
Coexpression	NABA_MATRISOME	PLXNA3 HGFAC EGLN3 MASP1 VWF CRIM1 ADAMTS8 PLXND1 ZP2 SSPOP CD209 MEGF8 PLXNC1 SLIT1 NTN5 FGB SERPINF2	2.18e-07	1008	99	17	MM17056
Coexpression	NABA_ECM_GLYCOPROTEINS	LAMB4 VWF CRIM1 ZP2 SSPOP SLIT1 NTN5 FGB	8.11e-07	196	99	8	M3008
Coexpression	NABA_ECM_GLYCOPROTEINS	VWF CRIM1 ZP2 SSPOP SLIT1 NTN5 FGB	8.26e-06	191	99	7	MM17059
Coexpression	NABA_CORE_MATRISOME	LAMB4 VWF CRIM1 ZP2 SSPOP SLIT1 NTN5 FGB	9.95e-06	275	99	8	M5884
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BCL11A TMEM200B PLXNC1 KBTBD11 NTN5 FRMD5	2.11e-06	165	101	6	479962ce1c3d6636ae62b6709635299748653801
ToppCell	AT1-AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	GGT6 UPK3B ALS2CL KIF7 LRP5 CACNA1H	2.68e-06	172	101	6	0be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell	LA-11._Adipocyte\|LA / Chamber and Cluster_Paper	PDE3B MYCBP2 ZBED3 LRP1B TMEM132C CRLS1	3.84e-06	183	101	6	3f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCell	15-Distal-RBC\|Distal / Age, Tissue, Lineage and Cell class	HGFAC PRSS57 YPEL4 AGXT FGB GLTPD2	4.48e-06	188	101	6	c68ccb1c5c21d13ddac09b16e7d466f0530bbda5
ToppCell	15-Distal-RBC-RBC\|Distal / Age, Tissue, Lineage and Cell class	HGFAC PRSS57 YPEL4 AGXT FGB GLTPD2	4.48e-06	188	101	6	2534684e4932c1255c24a26ca2277ac7af0a118b
ToppCell	Transverse-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	EGLN3 BCL11A ZBED3 PLEK SERPINF2	2.43e-05	151	101	5	6870f3b5d2bfad849c3203658b5f28f0ae181295
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	LINC01547 ALS2CL SSPOP TMEM132C MEGF8	2.59e-05	153	101	5	e7d20c88466ff81db613869cf7a6a4bb95fd6c2f
ToppCell	Frontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Igsf8_(Ctps)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ATP6V1B1 GGT6 SSPOP DEFB109B	3.16e-05	79	101	4	eddad041c0bc6952d9c68a36bdd78f6d661f0e58
ToppCell	Frontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Igsf8_(Ctps)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ATP6V1B1 GGT6 SSPOP DEFB109B	3.16e-05	79	101	4	4c9c3051cb8a9c39c6df20e3fe37242db4b44280
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC ACAA1 AGXT FGB SERPINF2	3.31e-05	161	101	5	274838cebdc7af1db32d309dfe42ef7ccd3c190b
ToppCell	droplet-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC ACAA1 AGXT FGB SERPINF2	3.51e-05	163	101	5	a794540f2d8984f963c08f05175e4bc916fcc224
ToppCell	ILEUM-non-inflamed-(3)_pDC\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	EGLN3 PRSS57 BCL11A SERPINF2 CKMT1A	3.51e-05	163	101	5	bc5411702badab39143905aa51676b4bbfad2041
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC ACAA1 AGXT FGB SERPINF2	3.51e-05	163	101	5	03d9fa615d9d02ef98e20f28a10aaa6894dd4960
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC ACAA1 AGXT FGB SERPINF2	3.51e-05	163	101	5	1c4de36cf8cdaabb981cda5c7ce7e5ae7b4280e3
ToppCell	droplet-Liver-Hepatocytes-18m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC ACAA1 AGXT FGB SERPINF2	3.51e-05	163	101	5	7e82c1b7849eca895732df2da74ac6430bd9ba7a
ToppCell	Ionocyte\|World / shred by cell class for turbinate	ATP6V1B1 ITGB3 PLA2G4C AGXT ADGRA1	3.72e-05	165	101	5	0cb2199b87f17ece743fb2652b2f448dfa78ae0b
ToppCell	facs-Aorta-Heart-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAA1 GGT6 KRTCAP3 SERPINF2 CKMT1A	4.17e-05	169	101	5	daed9083ee05c220365200328c2c50047fe21efd
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3B MYCBP2 ALS2CL ITGB3 KBTBD11	4.29e-05	170	101	5	90f7640f04672c800cb28aea50004b1bb0565e8a
ToppCell	E12.5-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HGFAC KRTCAP3 AGXT FGB SERPINF2	4.41e-05	171	101	5	a4d6b0f57eead11b01153688b06b2a45a3b488f2
ToppCell	-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	LAMB4 ADAMTS8 TMEM132C SLIT1 PDZRN3	4.66e-05	173	101	5	88be9182fbb1bc83531cd41e59ea57c112a21d54
ToppCell	COVID-mDC1-\|COVID / Condition, Cell_class and T cell subcluster	EGLN3 BCL11A SPTBN5 NTN5 SERPINF2	4.92e-05	175	101	5	83a95d6fc2ddf3ec53f05825bbc982fb8d2ccd15
ToppCell	COVID-mDC1\|COVID / Condition, Cell_class and T cell subcluster	EGLN3 BCL11A SPTBN5 NTN5 SERPINF2	4.92e-05	175	101	5	b9280444016e21c28131a61df65cc5c56d402412
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_A2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	BCL11A YPEL4 KRTCAP3 LRP5 IQGAP3	5.06e-05	176	101	5	052b54c4337ca728974a106b6dbd3b72dd28eb23
ToppCell	COVID-19-kidney-PCT-S3-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HGFAC CALHM3 AGXT FGB SERPINF2	5.06e-05	176	101	5	b6497324e3e52f514ce556a3fa0c3011c45dcc7b
ToppCell	356C-Endothelial_cells-Endothelial-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	VWF CRIM1 ITGB3 ADM5 MEOX1	5.20e-05	177	101	5	a0b172f40e0df97a288a5549ae7066697ad469b3
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Paneth\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KRTCAP3 AGXT FGB KAAG1 CKMT1A	5.20e-05	177	101	5	2af09028014f4ec3b7d2a4c286f1ae5e84a9f590
ToppCell	356C-Endothelial_cells-Endothelial-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	VWF CRIM1 ITGB3 ADM5 MEOX1	5.20e-05	177	101	5	ab8f09e118e4df696b0b4d33f013da020bdbd351
ToppCell	RV-11._Adipocyte\|RV / Chamber and Cluster_Paper	NRIP1 PDE3B MYCBP2 TMEM132C CRLS1	5.34e-05	178	101	5	278bbea5cf8f0589f71675c7a3d00679391b5253
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CRIM1 UPK3B GRM6 TMEM200B NKAIN4	5.34e-05	178	101	5	c77a1d1a9aef0ab51b4408b9e84f201219788ca2
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_Erythro-Mega\|lymph-node_spleen / Manually curated celltypes from each tissue	VWF PRSS57 ITGB3 PLA2G4C IQGAP3	5.48e-05	179	101	5	4e0cf069bc47328eda753a4edc7e89b8915d52bb
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HGFAC LAMB4 ITGB3 TMEM200B PDZRN3	5.78e-05	181	101	5	fc51468c74534b60b4e786bd512d0f1c5dc05de7
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	EGLN3 CRIM1 BCL11A LRP5 SERPINF2	5.93e-05	182	101	5	9bbe8062aa562dc3b9c299581faf6ebbcb72a9f7
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	EGLN3 CRIM1 BCL11A LRP5 SERPINF2	5.93e-05	182	101	5	4602a98df7045e2c70b7560abfba9b444fbd5d30
ToppCell	wk_15-18-Epithelial-PNS-Early_Schwann\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	KLK6 SPTBN5 NKAIN4 DLL3 CKMT1A	6.09e-05	183	101	5	7e8366ec8117d36cec67f77dcb0e9a6032d87fcb
ToppCell	LA-11._Adipocyte\|World / Chamber and Cluster_Paper	PDE3B ZBED3 LRP1B TMEM132C CRLS1	6.09e-05	183	101	5	b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCell	facs-Spleen-nan-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3B KIF1B ALS2CL ITGB3 KBTBD11	6.25e-05	184	101	5	c37c623c4a5ff1628486d8a6461fa355ad5c264c
ToppCell	droplet-Fat-Mat-18m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF CRIM1 ADAMTS8 LRP5 UFSP1	6.41e-05	185	101	5	d9be5853acdda7b1ac819cf50c7940d1d2362d15
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF PLXND1 ZP2 PLA2G4C KBTBD11	6.41e-05	185	101	5	fb84fcf7f51f53489bcb3962fa9cb483e48257ed
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-lymphatic\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	VWF PLXND1 ZP2 PLA2G4C KBTBD11	6.57e-05	186	101	5	86b218a400f9c64f92b050f00b49f09647b17437
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	VWF PLXND1 ZP2 PLA2G4C KBTBD11	6.57e-05	186	101	5	f51c76b1c3c6c49e0ebc9a913d8413e0b6a04d80
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF PLXND1 ZP2 PLA2G4C KBTBD11	6.57e-05	186	101	5	9d250d5ae7cf9129be05b41d70cb6c3a046c5f1e
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-bladder_urothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAA1 UPK3B KRTCAP3 KBTBD11 CKMT1A	6.74e-05	187	101	5	aa336fb568a24e12c0454265ddd71ed10a6614cf
ToppCell	3'_v3-blood-Myeloid_Dendritic-DC1\|blood / Manually curated celltypes from each tissue	EGLN3 BCL11A PIGZ PLEK SERPINF2	6.91e-05	188	101	5	411d4dd5c9dee7ebd8db352640cf009e7b033ba9
ToppCell	RA-11._Adipocyte\|World / Chamber and Cluster_Paper	NRIP1 PDE3B MYCBP2 LRP1B TMEM132C	6.91e-05	188	101	5	4dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF PLXND1 PLA2G4C KBTBD11 UBR3	7.27e-05	190	101	5	32400c62cb9de4c2b24af4206c21a0215ab12212
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HGH1 YPEL4 SERPINF2 IQGAP3 UFSP1	7.27e-05	190	101	5	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF PLXND1 PLA2G4C KBTBD11 UBR3	7.27e-05	190	101	5	b2bd2cb384bb8a5662064ed1aee68e905e1f780d
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF CRIM1 PLXND1 ADM5 MEOX1	7.64e-05	192	101	5	eafead22bba48ac5ee568faa8946c444445c1034
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF PLXND1 ZP2 PLA2G4C KBTBD11	7.64e-05	192	101	5	fa0ef05a32c661bdd59b5a9b6f75fd647ee937f3
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF PLXND1 ZP2 PLA2G4C KBTBD11	7.64e-05	192	101	5	4e63d95f75fe6eb3f817e84528883e95093c5bbd
ToppCell	droplet-Bladder-nan-3m-Epithelial-basal_bladder_epithelial_cell_(Krt5+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRIP1 ACAA1 KBTBD11 TNKS2 CKMT1A	7.82e-05	193	101	5	268925bfe85fb94a93a4ff8fe078d692df888140
ToppCell	Endothelial\|World / shred by cell class for bronchial biopsy	VWF CRIM1 PLXND1 ADM5 MEOX1	8.21e-05	195	101	5	f0e46e859f7a9bdead3203889f7e20fa21f76ff0
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-HSC-MPP\|bone_marrow / Manually curated celltypes from each tissue	PRSS57 MRPL12 BCL11A ZBED3 KBTBD11	8.41e-05	196	101	5	2440201ff08a88d7e4d92dd6e9ff4d0e271605eb
ToppCell	mild-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EGLN3 BCL11A LRP5 SERPINF2 PDZRN3	8.62e-05	197	101	5	0cb00daa6943f7a7fb34a8fdf51188646af65686
ToppCell	Influenza-Influenza_Severe-Myeloid-pDC\|Influenza_Severe / Disease, condition lineage and cell class	EGLN3 BCL11A ZBED3 KLHDC9 SERPINF2	8.62e-05	197	101	5	e8e6f71e6dc8a695e4321a18543c1df63dd62f3e
ToppCell	mild-pDC\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EGLN3 BCL11A LRP5 SERPINF2 PDZRN3	8.62e-05	197	101	5	15230a54fa5903dd728de1a0ad633bd2d2c7a04d
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF CRIM1 PLXND1 ADM5 MEOX1	8.83e-05	198	101	5	5b86dc00acf8ac2ede008f5d79c09996485bf250
ToppCell	Transverse-(5)_Dendritic_cell-(51)_cDC1\|Transverse / shred on region, Cell_type, and subtype	EGLN3 BCL11A ZBED3 PLEK SERPINF2	9.04e-05	199	101	5	52dd1c4cd372f8ee515307a9200e357bb2145888
ToppCell	Transverse-Dendritic_cell-cDC1\|Transverse / Region, Cell class and subclass	EGLN3 BCL11A ZBED3 PLEK SERPINF2	9.04e-05	199	101	5	b68419939d206417158a703f60a374bf8ec5d5a1
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1-Trf\|Thalamus / BrainAtlas - Mouse McCarroll V32	KLK6 GGT6 PIGZ DEFB109B	1.23e-04	112	101	4	cb351e57c99aaaf9ae6c7ff7e8ce5375552b1639
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)\|Thalamus / BrainAtlas - Mouse McCarroll V32	KLK6 GGT6 PIGZ DEFB109B	1.23e-04	112	101	4	999b5eeed4305e1a1385aadbaf017b64f21c1ee0
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	KLK6 GGT6 PIGZ DEFB109B	1.23e-04	112	101	4	004cd69b66c3b26b9a61f03279b48230da351574
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1\|Thalamus / BrainAtlas - Mouse McCarroll V32	KLK6 GGT6 PIGZ DEFB109B	1.23e-04	112	101	4	502e3f356f6e1c959bff0a39c98f33f863ce8265
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O2\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	KLK6 SSPOP PIGZ DEFB109B	1.71e-04	122	101	4	d4152c45dfbb979ddf8380b4896db753a79cad9e
ToppCell	Frontal_cortex-Macroglia-OLIGODENDROCYTE-O2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	KLK6 SSPOP PIGZ DEFB109B	1.71e-04	122	101	4	2880f25d10a7765e55a2aa20c7a6ef74cea19c4d
ToppCell	Frontal_cortex-Macroglia-OLIGODENDROCYTE\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	KLK6 SSPOP PIGZ DEFB109B	1.71e-04	122	101	4	ecd0e54dd829201290212ea2ff7c8e7eec19c0e9
ToppCell	Frontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	KLK6 SSPOP PIGZ DEFB109B	1.71e-04	122	101	4	cffd7730bda90828efc0def452cabb44cf93ab48
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O2-Trf\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	KLK6 SSPOP PIGZ DEFB109B	1.71e-04	122	101	4	40f983623c990203df4ba997e296231489d51012
Drug	Rgdf peptide	VWF ITGB3 FGB SERPINF2	3.13e-07	14	98	4	CID003080994
Disease	Osteoporosis	HDAC5 FGB LRP5 PLEK	3.85e-05	63	88	4	C0029456
Disease	venous thromboembolism, fibrinogen measurement	HGFAC VWF FGB PLEK	4.90e-05	67	88	4	EFO_0004286, EFO_0004623
Disease	pulse pressure measurement	HGFAC NRIP1 CRIM1 TRIM65 ADAMTS8 SSPOP ABHD17C MEGF8 PLXNC1 SLIT1 UBR3 TMEM270 FER1L5	2.41e-04	1392	88	13	EFO_0005763
Disease	end stage renal disease (is_implicated_in)	VWF ITGB3 FGB	2.52e-04	41	88	3	DOID:783 (is_implicated_in)
Disease	fibrinogen measurement, tissue plasminogen activator measurement	HGFAC PLXND1 FGB	3.32e-04	45	88	3	EFO_0004623, EFO_0004791
Disease	diastolic blood pressure, alcohol drinking	EVX1 SLIT1 AGXT FER1L5	4.37e-04	118	88	4	EFO_0004329, EFO_0006336
Disease	early cardiac repolarization measurement	MYCBP2 LRP5	7.82e-04	14	88	2	EFO_0004885
Disease	Osteoporosis, Age-Related	FGB LRP5 PLEK	8.14e-04	61	88	3	C0001787
Disease	Post-Traumatic Osteoporosis	FGB LRP5 PLEK	8.14e-04	61	88	3	C0751406
Disease	Osteoporosis, Senile	FGB LRP5 PLEK	8.14e-04	61	88	3	C0029459
Disease	idiopathic scoliosis (implicated_via_orthology)	SSPOP KIF7	1.03e-03	16	88	2	DOID:0060250 (implicated_via_orthology)
Disease	Van Buchem disease	DLL3 LRP5	1.16e-03	17	88	2	C0432272
Disease	level of Sphingomyelin (d34:1) in blood serum	USP24 GLTPD2	1.30e-03	18	88	2	OBA_2045175
Disease	schizophrenia (is_implicated_in)	RTN4R BCL11A HPS4	1.66e-03	78	88	3	DOID:5419 (is_implicated_in)
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	VWF PLEK	1.78e-03	21	88	2	EFO_0004286, EFO_0004792
Disease	venous thromboembolism, tissue plasminogen activator measurement	VWF PLEK	2.14e-03	23	88	2	EFO_0004286, EFO_0004791
Disease	response to radiation, Hematuria	AGXT PLEK	2.14e-03	23	88	2	GO_0009314, HP_0000790
Disease	left ventricular structural measurement	EVX1 ITGB3 PDZRN3	2.34e-03	88	88	3	EFO_0008205
Disease	cardiovascular disease	HGFAC MACROD1 ABHD17C SPTBN5 NKAIN4 AGXT	2.48e-03	457	88	6	EFO_0000319

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGSAHLAGLAGRCSL	nan	41	Q9HAA7
CQGLEHGFGIRLLPQ	ALS2CL	386	Q60I27
LAGDALPGCLGAAAH	LINC01547	76	P58512
GPELHSGCLDGLRSL	C6orf136	96	Q5SQH8
IRCLHQGALGEGQPR	ADM5	56	C9JUS6
HLLSRLCQDLGPGAF	SERPINF2	146	P08697
LLDGGHGDCLLDAPA	ADAMTS8	416	Q9UP79
CGGGLSHRAPTLALG	CALHM3	321	Q86XJ0
ACHSGPANGLAPRAA	EVX1	351	P49640
LPGATCLQGEGQGHL	GSDMD	186	P57764
AALGRAACLHSPGLG	ADGRA1	336	Q86SQ6
AACLHSPGLGQPRGF	ADGRA1	341	Q86SQ6
DILLQHGCPGEGGSA	AGAP2	1141	Q99490
QHTGECAVGLLGPRG	ERVV-2	291	B6SEH9
GCLGHGPLVLQLLSF	CD209	36	Q9NNX6
VHLSLANCPIGDGGL	CEP78	151	Q5JTW2
PCRNGGLCLDLGHAL	DLL3	361	Q9NYJ7
IDNGGELHAGSALCP	CEMIP	101	Q8WUJ3
HCTGALRDGQLAGPR	EGLN3	51	Q9H6Z9
CGLPLTHGEQRAGGH	PDZRN3	146	Q9UPQ7
CLRNPHSEGNGASGL	MEOX1	21	P50221
GSGRGPCHLANLLST	NOBOX	236	O60393
SHLQELLARGAGPAG	KLHL34	156	Q8N239
LNGGCHDLCLLTPNG	LRP1B	2471	Q9NZR2
CLHRVATGALGGPDA	GLTPD2	196	A6NH11
LHDGLRQVAGPGAAA	KAAG1	21	Q9UBP8
SCHLGPGAACLSLRG	MYO15A	1176	Q9UKN7
HLGQGQPRELAGCGS	NADK2	46	Q4G0N4
GGRLGHGDEQTCLVP	IBTK	206	Q9P2D0
AGLPCQGTFLLHQGI	KIF1B	1276	O60333
GCLSGHDLESIRPAG	HPS4	326	Q9NQG7
GQCGQLCLAIPGGHR	LRP5	911	O75197
LGAPEGDHDLLTCGQ	BCL11A	36	Q9H165
PLGIGIATGEQCHNR	ENOSF1	296	Q7L5Y1
QHTGECAVGLLGPRG	ERVV-1	291	B6SEH8
DAGGCLHADPDLGVL	FGB	91	P02675
FCGLVLNQPLGGLHV	PLXNA3	386	P51805
LDCGHGHPDGRRLLL	PLXNC1	281	O60486
SLLARICLPHGAGGD	PLXND1	316	Q9Y4D7
LVGGAGCLLALGLDH	PDE3B	251	Q13370
LHGHQSCLQVEPGLG	KIF7	31	Q2M1P5
HGDPRRGHCDNLSGL	MEGF8	1216	Q7Z7M0
EHLGCAGSRPESGLL	NRIP1	1016	P48552
AAALLGLGPHAYCRN	HGFAC	326	Q04756
AAGGALAAPQRHALG	IQGAP3	1196	Q86VI3
VLGSGGGLRAHIACL	PLA2G4C	46	Q9UP65
GGELRALCQGHSGPE	FRMD5	476	Q7Z6J6
PVHARGAAGRACGQL	GRM6	46	O15303
RGTEGLCPLLCHADG	GGT6	226	Q6P531
GDRGLAGCGHLLVSL	CRIM1	6	Q9NZV1
GAGPGACSLHLSERA	ABHD17C	81	Q6PCB6
RGGLGPAEGHCLNLF	DEFB109B	21	Q30KR1
GGVDGCIHRAAGPLL	MACROD1	181	Q9BQ69
LSHLNGQPFCGGSLL	MASP1	466	P48740
GRLAGIVQPNDGQCH	ITGB3	286	P05106
HPGHQLLLFGGCNLA	KLHDC9	201	Q8NEP7
GACHPTTGDLLVGRN	LAMB4	26	A4D0S4
CLLGVALEGDGSPHG	HDAC5	426	Q9UQL6
CSLAVTPNGHLEGRG	CACNA1H	1056	O95180
ARDLCQAHGLPLDGE	SAC3D1	336	A6NKF1
ALNGGHCLAQPAAEP	SLC39A13	191	Q96H72
HCLAQPAAEPGLGAV	SLC39A13	196	Q96H72
LGLRLPGIGQRNHCS	CRLS1	56	Q9UJA2
DCARAGLLLAPGHQG	NOA1	271	Q8NC60
CPSNLGTGLRAGVHI	CKMT1A	316	P12532
VANGGRRLIADCHPG	KRTCAP3	121	Q53RY4
CGPGRALLAGQAALL	HGH1	51	Q9BTY7
HLDRCGLQELGPGLF	RTN4R	136	Q9BZR6
DGGPGTECRHLQQLL	SZT2	1941	Q5T011
GLPGSSCNLGAAREH	ATP6V1B1	11	P15313
GVLQPLDGFGELCHR	AGXT	161	P21549
GAVALGHPLGCTGAR	ACAA1	371	P09110
ADGRCLPPALLCDGH	SSPOP	1461	A2VEC9
GGAPCAGERHQARLC	SSPOP	4041	A2VEC9
GPGACEESNHLLLNG	TMEM132C	1001	Q8N3T6
GELLLGAPAARDCAH	TMEM200B	266	Q69YZ2
LFSPAGALHSGRLCG	FER1L5	721	A0AVI2
PGNHLGARETCNGSL	NTN5	51	Q8WTR8
AGAEDPLGAIHLRGC	PLEK	281	P08567
ADSGGPLVCRNRAHG	PRSS57	216	Q6UWY2
QLGHGDVNSRGCPTL	MYCBP2	971	O75592
GEAAALPCGHSLCRG	RNF169	76	Q8NCN4
AGRAHLLAAALGPAG	KBTBD11	291	O94819
ALPGIGHACGHNLIA	PM20D2	116	Q8IYS1
REGLAHLIQSCGLGG	SLC12A4	771	Q9UP95
CRLGQLHPAAPGGLA	SPTBN5	3276	Q9NRC6
GHQRCEALAGAPLDN	MRPL12	41	P52815
APHGQALVSGAGCAL	NKAIN4	126	Q8IVV8
QAHLPLGAAACPLGQ	TMEM270	61	Q6UE05
LDDAAARGGQCPGLG	ZBED3	16	Q96IU2
VILHNGACSPGARQG	VWF	1986	P04275
LLNCSLLLCRGGGHP	SPHK2	301	Q9NRA0
SLCLAHFGGPQGRLC	UFSP1	21	Q6NVU6
ALPLCGHRDRLGGQH	SCART1	716	Q4G0T1
LFGCLHQGGLVPGLE	PIGZ	426	Q86VD9
ARDDGGLIPLHNACS	TNKS2	86	Q9H2K2
GCGPAEQRLLLTGLH	YPEL4	66	Q96NS1
LIACHRLAAAVAGPG	USP24	676	Q9UPU5
LELIHRGGNLCSGGA	UBR3	1461	Q6ZT12
GALAEPCRGLQCLHG	SLIT1	1416	O75093
SRLCGLLLEEGSHPG	TRIM65	281	Q6PJ69
GPGAAADRLLHGQAL	UPK3B	261	Q9BT76
SQGLVRFHIPLNGCG	ZP2	411	Q05996
PAGGGAEALELLEHC	TRIM28	51	Q13263
DSGGPLVCGDHLRGL	KLK6	196	Q92876