Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN3A CAPN3 SCN9A

2.27e-0914845GO:0031402
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN2A SCN3A SCN9A SCN10A

7.17e-0826845GO:0005248
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN3A CAPN3 SCN9A

7.17e-0826845GO:0031420
GeneOntologyMolecularFunctionsodium channel activity

SCN1A SCN2A SCN3A SCN9A SCN10A

2.60e-0652845GO:0005272
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

SCN1A SCN2A SCN10A

4.68e-0517843GO:0099508
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR1 RYR2

1.04e-044842GO:0005219
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SCN1A SCN2A SCN3A SCN9A SCN10A HRH1 ATP2A2 RYR1 RYR2

1.46e-04465849GO:0046873
GeneOntologyMolecularFunctionenzyme regulator activity

DOCK5 FRY TBC1D15 PPP2R3A PTPA PDE8A CAPN3 PPME1 ITPRIP C4A C4B APOA4 OCRL ADGRV1 SERPINA6 ARAP2

2.45e-0414188416GO:0030234
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR1 RYR2

2.59e-046842GO:0048763
GeneOntologyMolecularFunctionsulfur compound binding

PTPRS LRP1 FGFR2 TNXB RYR2 SMAD4 IMPG2

4.24e-04323847GO:1901681
GeneOntologyMolecularFunctionacetylgalactosaminyltransferase activity

GALNT1 CHPF2 GALNT4

4.26e-0435843GO:0008376
GeneOntologyMolecularFunctionmonoatomic cation channel activity

SCN1A SCN2A SCN3A SCN9A SCN10A RYR1 RYR2

6.06e-04343847GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion channel activity

SCN1A SCN2A SCN3A SCN9A SCN10A RYR1 RYR2 GABRA6

6.94e-04459848GO:0005216
GeneOntologyMolecularFunctioncomplement component C1q complex binding

C4A C4B

7.70e-0410842GO:0001849
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SCN1A SCN2A SCN3A SCN9A SCN10A

7.77e-04171845GO:0015081
GeneOntologyMolecularFunctionphosphoric ester hydrolase activity

PTPN5 PTPA PDE8A PTPRS PDE8B OCRL CTDNEP1

1.21e-03386847GO:0042578
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SCN1A SCN2A SCN3A SCN9A SCN10A HRH1 ATP2A2 RYR1 RYR2

1.27e-03627849GO:0022890
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SCN1A SCN2A SCN3A SCN9A SCN10A HRH1 ATP2A2 RYR1 RYR2 GABRA6

1.28e-037588410GO:0015318
GeneOntologyMolecularFunctioncytidine deaminase activity

APOBEC3B APOBEC3F

1.32e-0313842GO:0004126
GeneOntologyMolecularFunctionchannel activity

SCN1A SCN2A SCN3A SCN9A SCN10A RYR1 RYR2 GABRA6

1.64e-03525848GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SCN1A SCN2A SCN3A SCN9A SCN10A RYR1 RYR2 GABRA6

1.66e-03526848GO:0022803
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SCN1A SCN2A SCN3A SCN9A SCN10A HRH1 ATP2A2 RYR1 RYR2 GABRA6

1.79e-037938410GO:0015075
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SCN1A SCN2A SCN3A SCN9A SCN10A HRH1 ATP2A2 RYR1 RYR2

1.88e-03664849GO:0008324
GeneOntologyMolecularFunctioncarbohydrate binding

IGF2R GALNT1 C4A C4B CHID1 GALNT4

1.97e-03310846GO:0030246
GeneOntologyMolecularFunctioncalcium-dependent cysteine-type endopeptidase activity

CAPN3 CAPN5

2.28e-0317842GO:0004198
GeneOntologyMolecularFunctionenzyme inhibitor activity

FRY PPME1 ITPRIP C4A C4B ADGRV1 SERPINA6

2.38e-03435847GO:0004857
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR1 RYR2

2.56e-0318842GO:0015278
GeneOntologyMolecularFunctiongated channel activity

SCN1A SCN2A SCN10A RYR1 RYR2 GABRA6

2.85e-03334846GO:0022836
GeneOntologyMolecularFunctionpolypeptide N-acetylgalactosaminyltransferase activity

GALNT1 GALNT4

3.16e-0320842GO:0004653
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

HRH1 ATP2A2 RYR1 RYR2

3.80e-03151844GO:0015085
GeneOntologyMolecularFunction3',5'-cyclic-AMP phosphodiesterase activity

PDE8A PDE8B

3.82e-0322842GO:0004115
GeneOntologyMolecularFunctioncalcium ion binding

PPP2R3A DSG1 CAPN3 LRP1 ADAMTS13 ADGRV1 ATP2A2 RYR1 RYR2

4.19e-03749849GO:0005509
GeneOntologyMolecularFunctioncopper ion binding

CP APOA4 F8

4.35e-0378843GO:0005507
GeneOntologyMolecularFunction3',5'-cyclic-GMP phosphodiesterase activity

PDE8A PDE8B

4.54e-0324842GO:0047555
GeneOntologyMolecularFunctioncollagen binding

DPP4 TNXB SMAD4

4.84e-0381843GO:0005518
GeneOntologyMolecularFunction3',5'-cyclic-nucleotide phosphodiesterase activity

PDE8A PDE8B

4.93e-0325842GO:0004114
GeneOntologyMolecularFunctionopsonin binding

C4A C4B

4.93e-0325842GO:0001846
GeneOntologyMolecularFunctioncysteine-type endopeptidase activity

ATG4A CAPN3 CAPN5

5.72e-0386843GO:0004197
GeneOntologyMolecularFunctioncyclic-nucleotide phosphodiesterase activity

PDE8A PDE8B

5.73e-0327842GO:0004112
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SCN1A SCN2A SCN3A SCN9A SCN10A ATP2A2 RYR2

5.95e-0887837GO:0086001
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN1A SCN2A SCN3A SCN9A SCN10A ATP2A2 RYR2

9.47e-0893837GO:0086003
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN1A SCN2A SCN3A SCN9A SCN10A RYR2

1.81e-0762836GO:0086002
GeneOntologyBiologicalProcessstriated muscle contraction

SCN1A SCN2A SCN3A SCN9A SCN10A ATP2A2 RYR1 RYR2 CHUK

2.24e-07217839GO:0006941
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN1A SCN2A SCN3A SCN9A SCN10A

3.19e-0736835GO:0086010
GeneOntologyBiologicalProcessactin-mediated cell contraction

SCN1A SCN2A SCN3A SCN9A SCN10A ATP2A2 RYR2

8.00e-07127837GO:0070252
GeneOntologyBiologicalProcessactin filament-based movement

SCN1A SCN2A SCN3A SCN9A SCN10A ATP2A2 RYR2

2.79e-06153837GO:0030048
GeneOntologyBiologicalProcessmuscle contraction

DOCK5 SCN1A SCN2A SCN3A SCN9A SCN10A ATP2A2 RYR1 RYR2 CHUK

4.64e-064008310GO:0006936
GeneOntologyBiologicalProcesscardiac muscle contraction

SCN1A SCN2A SCN3A SCN9A SCN10A ATP2A2 RYR2

4.98e-06167837GO:0060048
GeneOntologyBiologicalProcessneuronal action potential

SCN1A SCN2A SCN3A SCN9A SCN10A

5.47e-0663835GO:0019228
GeneOntologyBiologicalProcessmuscle system process

DOCK5 SCN1A SCN2A SCN3A SCN9A SCN10A ATP2A2 RYR1 RYR2 SMAD4 CHUK

1.19e-055478311GO:0003012
GeneOntologyBiologicalProcessaction potential

SCN1A SCN2A SCN3A SCN9A SCN10A ATP2A2 RYR2

1.67e-05201837GO:0001508
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception of pain

SCN1A SCN9A SCN10A PRDM12

2.67e-0543834GO:0062149
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception

SCN1A SCN9A SCN10A ADGRV1

8.19e-0557834GO:0050974
GeneOntologyBiologicalProcesstransmission of nerve impulse

SCN1A SCN2A SCN3A SCN9A SCN10A

8.94e-05112835GO:0019226
GeneOntologyBiologicalProcessmembrane depolarization

SCN1A SCN2A SCN3A SCN9A SCN10A

1.29e-04121835GO:0051899
GeneOntologyBiologicalProcessdetection of temperature stimulus involved in sensory perception of pain

SCN9A SCN10A PRDM12

1.53e-0426833GO:0050965
GeneOntologyBiologicalProcessmulticellular organismal response to stress

DPP4 PDE8B SCN3A SCN9A SCN10A

1.56e-04126835GO:0033555
GeneOntologyBiologicalProcessheart contraction

SCN1A SCN2A SCN3A SCN9A SCN10A ATP2A2 RYR2

1.99e-04298837GO:0060047
GeneOntologyBiologicalProcessdetection of temperature stimulus involved in sensory perception

SCN9A SCN10A PRDM12

2.36e-0430833GO:0050961
GeneOntologyBiologicalProcessclearance of foreign intracellular DNA

APOBEC3B APOBEC3F

2.37e-046832GO:0044355
GeneOntologyBiologicalProcessclearance of foreign intracellular nucleic acids

APOBEC3B APOBEC3F

2.37e-046832GO:0099046
GeneOntologyBiologicalProcessdetection of mechanical stimulus

SCN1A SCN9A SCN10A ADGRV1

2.38e-0475834GO:0050982
GeneOntologyBiologicalProcessheart process

SCN1A SCN2A SCN3A SCN9A SCN10A ATP2A2 RYR2

2.48e-04309837GO:0003015
GeneOntologyBiologicalProcessmuscle cell differentiation

DOCK5 FKTN CAPN3 ATP11A FGFR2 ATP2A2 RYR1 SMAD4 CHUK

2.81e-04531839GO:0042692
GeneOntologyBiologicalProcessbehavioral response to pain

SCN3A SCN9A SCN10A

2.86e-0432833GO:0048266
GeneOntologyBiologicalProcessresponse to abiotic stimulus

DPP4 PDE8B SCN1A SCN2A CAPN3 SCN9A SCN10A HRH1 PRDM12 FGFR2 ADGRV1 RYR1 RYR2 SMAD4 CHUK

3.13e-0413618315GO:0009628
GeneOntologyBiologicalProcessdetection of temperature stimulus

SCN9A SCN10A PRDM12

3.14e-0433833GO:0016048
GeneOntologyBiologicalProcessleft ventricular cardiac muscle tissue morphogenesis

RYR2 SMAD4

3.32e-047832GO:0003220
GeneOntologyBiologicalProcessregulation of extracellular matrix organization

DPP4 LRP1 TNXB SMAD4

3.68e-0484834GO:1903053
GeneOntologyBiologicalProcesspositive regulation of apoptotic cell clearance

C4A C4B

4.41e-048832GO:2000427
GeneOntologyBiologicalProcesssensory perception of temperature stimulus

SCN9A SCN10A PRDM12

4.79e-0438833GO:0050951
GeneOntologyBiologicalProcessresponse to mechanical stimulus

SCN1A SCN9A SCN10A ADGRV1 RYR2 CHUK

4.85e-04247836GO:0009612
GeneOntologyBiologicalProcesscAMP catabolic process

PDE8A PDE8B

5.65e-049832GO:0006198
GeneOntologyBiologicalProcessregulation of lipase activity

LRP1 APOA4 FGFR2

6.00e-0441833GO:0060191
GeneOntologyBiologicalProcessmuscle structure development

DOCK5 PPP2R3A FKTN CAPN3 ATP11A FGFR2 ATP2A2 RYR1 RYR2 SMAD4 CHUK

6.34e-048588311GO:0061061
GeneOntologyBiologicalProcessdetection of external stimulus

SCN1A SCN9A SCN10A PRDM12 ADGRV1

6.71e-04173835GO:0009581
GeneOntologyBiologicalProcessDNA cytosine deamination

APOBEC3B APOBEC3F

7.05e-0410832GO:0070383
GeneOntologyBiologicalProcessprotein O-linked glycosylation via serine

GALNT1 GALNT4

7.05e-0410832GO:0018242
GeneOntologyBiologicalProcessprotein O-linked glycosylation via threonine

GALNT1 GALNT4

7.05e-0410832GO:0018243
GeneOntologyBiologicalProcessregulation of apoptotic cell clearance

C4A C4B

7.05e-0410832GO:2000425
GeneOntologyBiologicalProcessdetection of abiotic stimulus

SCN1A SCN9A SCN10A PRDM12 ADGRV1

7.07e-04175835GO:0009582
GeneOntologyBiologicalProcesscirculatory system process

DOCK5 SCN1A SCN2A SCN3A SCN9A SCN10A LRP1 HRH1 ATP2A2 RYR2

7.08e-047338310GO:0003013
GeneOntologyBiologicalProcesssarcoplasmic reticulum calcium ion transport

ATP2A2 RYR1 RYR2

7.39e-0444833GO:0070296
GeneOntologyBiologicalProcesssteroid metabolic process

ARV1 PDE8B LRP1 HRH1 APOA4 SERPINA6 TIPARP

8.00e-04376837GO:0008202
GeneOntologyBiologicalProcessextracellular matrix organization

DPP4 FKTN LRP1 ADAMTS13 TNXB SMAD4 IMPG2

8.13e-04377837GO:0030198
GeneOntologyBiologicalProcessextracellular structure organization

DPP4 FKTN LRP1 ADAMTS13 TNXB SMAD4 IMPG2

8.26e-04378837GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

DPP4 FKTN LRP1 ADAMTS13 TNXB SMAD4 IMPG2

8.38e-04379837GO:0045229
GeneOntologyBiologicalProcesssensory perception of pain

SCN1A SCN9A SCN10A PRDM12

8.56e-04105834GO:0019233
GeneOntologyBiologicalProcesscellular response to caffeine

RYR1 RYR2

8.59e-0411832GO:0071313
GeneOntologyBiologicalProcessapoptotic cell clearance

LRP1 C4A C4B

9.54e-0448833GO:0043277
GeneOntologyBiologicalProcessstriated muscle cell differentiation

DOCK5 FKTN CAPN3 ATP11A RYR1 SMAD4 CHUK

1.01e-03391837GO:0051146
GeneOntologyBiologicalProcesscytidine to uridine editing

APOBEC3B APOBEC3F

1.03e-0312832GO:0016554
GeneOntologyBiologicalProcessAV node cell to bundle of His cell signaling

SCN10A RYR2

1.03e-0312832GO:0086027
GeneOntologyBiologicalProcessAV node cell action potential

SCN10A RYR2

1.03e-0312832GO:0086016
GeneOntologyBiologicalProcessmanganese ion transmembrane transport

HRH1 RYR2

1.03e-0312832GO:0071421
GeneOntologyBiologicalProcessactin filament-based process

SCN1A SCN2A SCN3A CAPN3 SCN9A SCN10A LRP1 ATP2A2 TNXB RYR2 SMAD4

1.04e-039128311GO:0030029
GeneOntologyBiologicalProcessresponse to toxic substance

SCN3A SCN9A CP APOA4 ADAMTS13 CHUK

1.10e-03289836GO:0009636
GeneOntologyBiologicalProcessresponse to pain

SCN3A SCN9A SCN10A

1.14e-0351833GO:0048265
GeneOntologyBiologicalProcessblood circulation

DOCK5 SCN1A SCN2A SCN3A SCN9A SCN10A HRH1 ATP2A2 RYR2

1.17e-03648839GO:0008015
GeneOntologyBiologicalProcessregulation of muscle contraction

DOCK5 SCN10A ATP2A2 RYR1 RYR2

1.34e-03202835GO:0006937
GeneOntologyBiologicalProcesscytidine catabolic process

APOBEC3B APOBEC3F

1.41e-0314832GO:0006216
GeneOntologyBiologicalProcesscyclic nucleotide catabolic process

PDE8A PDE8B

1.41e-0314832GO:0009214
GeneOntologyBiologicalProcessDNA deamination

APOBEC3B APOBEC3F

1.41e-0314832GO:0045006
GeneOntologyBiologicalProcessmanganese ion transport

HRH1 RYR2

1.41e-0314832GO:0006828
GeneOntologyBiologicalProcesscytidine metabolic process

APOBEC3B APOBEC3F

1.41e-0314832GO:0046087
GeneOntologyBiologicalProcesscytidine deamination

APOBEC3B APOBEC3F

1.41e-0314832GO:0009972
GeneOntologyBiologicalProcesscellular response to purine-containing compound

RYR1 RYR2

1.41e-0314832GO:0071415
GeneOntologyBiologicalProcessresponse to metal ion

CAPN3 CP ADAMTS13 ADGRV1 RYR1 RYR2 CHUK

1.42e-03415837GO:0010038
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SCN1A SCN2A SCN3A SCN9A SCN10A

1.53e-03208835GO:0035725
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN2A SCN3A SCN9A SCN10A

4.89e-0917825GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN2A SCN3A SCN9A SCN10A

9.05e-0829825GO:0034706
GeneOntologyCellularComponentcation channel complex

PTPA SCN1A SCN2A SCN3A SCN9A SCN10A RYR1 RYR2

3.95e-06235828GO:0034703
GeneOntologyCellularComponenttransporter complex

PTPA SCN1A SCN2A SCN3A SCN9A SCN10A ATP11A ATP2A2 RYR1 RYR2 GABRA6

9.79e-065508211GO:1990351
GeneOntologyCellularComponentmonoatomic ion channel complex

PTPA SCN1A SCN2A SCN3A SCN9A SCN10A RYR1 RYR2 GABRA6

1.72e-05378829GO:0034702
GeneOntologyCellularComponenttransmembrane transporter complex

PTPA SCN1A SCN2A SCN3A SCN9A SCN10A ATP2A2 RYR1 RYR2 GABRA6

3.75e-055238210GO:1902495
GeneOntologyCellularComponentstereocilium membrane

ADGRV1 CLRN2

2.26e-046822GO:0060171
GeneOntologyCellularComponentT-tubule

SCN1A SCN2A CAPN3 RYR1

2.64e-0479824GO:0030315
GeneOntologyCellularComponentsymbiont cell surface

C4A C4B

4.19e-048822GO:0106139
GeneOntologyCellularComponentother organism part

C4A C4B

5.38e-049822GO:0044217
GeneOntologyCellularComponentjunctional sarcoplasmic reticulum membrane

RYR1 RYR2

6.70e-0410822GO:0014701
GeneOntologyCellularComponentsarcoplasmic reticulum membrane

ATP2A2 RYR1 RYR2

7.33e-0445823GO:0033017
GeneOntologyCellularComponentcytoplasmic side of plasma membrane

DSG1 ATP2A2 RYR1 RYR2 CHUK

8.09e-04185825GO:0009898
GeneOntologyCellularComponentsarcolemma

SCN1A SCN2A CAPN3 RYR1 RYR2

9.12e-04190825GO:0042383
GeneOntologyCellularComponentsarcoplasm

SCN3A ATP2A2 RYR1 RYR2

1.06e-03114824GO:0016528
GeneOntologyCellularComponentphosphatase complex

PPP2R3A PTPA CTDNEP1

1.32e-0355823GO:1903293
GeneOntologyCellularComponentprotein serine/threonine phosphatase complex

PPP2R3A PTPA CTDNEP1

1.32e-0355823GO:0008287
GeneOntologyCellularComponentextrinsic component of cytoplasmic side of plasma membrane

ATP2A2 RYR1 RYR2

1.39e-0356823GO:0031234
GeneOntologyCellularComponentmembrane protein complex

PTPA IGF2R SCN1A SCN2A SCN3A SCN9A SCN10A LRP1 CTDNEP1 ATP2A2 RYR1 RYR2 CHUK GABRA6

1.95e-0314988214GO:0098796
GeneOntologyCellularComponentcytoplasmic side of membrane

DSG1 ATP2A2 RYR1 RYR2 CHUK

2.12e-03230825GO:0098562
GeneOntologyCellularComponentprotein phosphatase type 2A complex

PPP2R3A PTPA

2.23e-0318822GO:0000159
GeneOntologyCellularComponentintercalated disc

SCN1A SCN2A ATP2A2

2.43e-0368823GO:0014704
GeneOntologyCellularComponentblood microparticle

CP C4A C4B APOA4

2.49e-03144824GO:0072562
GeneOntologyCellularComponentaxon

PTPN5 PTPRS SCN1A SCN2A SCN3A SCN9A SCN10A LRP1 C4A C4B

2.50e-038918210GO:0030424
GeneOntologyCellularComponentnode of Ranvier

SCN1A SCN2A

2.76e-0320822GO:0033268
GeneOntologyCellularComponentZ disc

SCN1A CAPN3 RYR1 RYR2

2.96e-03151824GO:0030018
GeneOntologyCellularComponentcalcium channel complex

PTPA RYR1 RYR2

2.97e-0373823GO:0034704
GeneOntologyCellularComponentperinuclear region of cytoplasm

IGF2R GALNT1 PDE8A PDE8B LRP1 ADGRV1 SRCAP ATP2A2 GALNT4 RYR1

3.51e-039348210GO:0048471
GeneOntologyCellularComponentneuron projection membrane

ADGRV1 CLRN2 GABRA6

4.12e-0382823GO:0032589
GeneOntologyCellularComponentI band

SCN1A CAPN3 RYR1 RYR2

4.15e-03166824GO:0031674
GeneOntologyCellularComponentpresynaptic membrane

PTPRS SCN1A SCN2A SCN10A GABRA6

4.69e-03277825GO:0042734
GeneOntologyCellularComponentsarcoplasmic reticulum

ATP2A2 RYR1 RYR2

5.02e-0388823GO:0016529
HumanPhenoGeneralized cerebral atrophy/hypoplasia

SCN1A SCN2A SCN9A ADGRV1

2.45e-0613414HP:0007058
HumanPhenoAtypical absence status epilepticus

SCN1A SCN2A SCN9A ADGRV1

7.97e-0617414HP:0011151
HumanPhenoGeneralized non-convulsive status epilepticus without coma

SCN1A SCN2A SCN9A ADGRV1

1.02e-0518414HP:0032860
HumanPhenoNon-convulsive status epilepticus without coma

SCN1A SCN2A SCN9A ADGRV1

1.59e-0520414HP:0032671
HumanPhenoTalipes valgus

SCN1A SCN2A SCN9A ADGRV1

1.96e-0521414HP:0004684
HumanPhenoPhotosensitive myoclonic seizure

SCN1A SCN2A SCN9A

2.64e-058413HP:0001327
HumanPhenoCyanotic episode

SCN1A SCN2A SCN9A

2.64e-058413HP:0200048
HumanPhenoTibial torsion

SCN1A SCN2A SCN9A ADGRV1

2.86e-0523414HP:0100694
HumanPhenoRigidity

PTPA PDE8B SCN1A SCN2A SCN3A SCN9A CP LSM11 RYR1

3.73e-05214419HP:0002063
HumanPhenoLimited knee extension

SCN1A SCN2A SCN9A ADGRV1

5.55e-0527414HP:0003066
HumanPhenoStatus epilepticus without prominent motor symptoms

SCN1A SCN2A SCN9A ADGRV1

5.55e-0527414HP:0031475
HumanPhenoLimited neck range of motion

SCN1A SCN2A SCN9A

7.64e-0511413HP:0000466
HumanPhenoEpilepsia partialis continua

SCN1A SCN2A SCN9A

1.01e-0412413HP:0012847
HumanPhenoCogwheel rigidity

SCN1A SCN2A SCN9A CP

1.10e-0432414HP:0002396
HumanPhenoObsessive-compulsive trait

SCN1A SCN2A SCN9A ADGRV1

1.25e-0433414HP:0008770
HumanPhenoAbnormal ankle morphology

SCN1A SCN2A CAPN3 SCN9A ADGRV1 RYR1

1.27e-04100416HP:0034673
HumanPhenoCalcaneovalgus deformity

SCN1A SCN2A SCN9A ADGRV1

1.41e-0434414HP:0001848
HumanPhenoDeformed tarsal bones

SCN1A SCN2A SCN9A ADGRV1

1.58e-0435414HP:0008119
HumanPhenoLimitation of knee mobility

SCN1A SCN2A SCN9A ADGRV1

1.58e-0435414HP:0010501
HumanPhenoDisturbance of facial expression

SCN1A SCN2A SCN9A CP

1.77e-0436414HP:0005324
HumanPhenoScapular muscle atrophy

FKTN CAPN3

1.89e-043412HP:0009060
HumanPhenoFacial tics

SCN1A SCN2A SCN9A

2.06e-0415413HP:0011468
HumanPhenoPhotosensitive tonic-clonic seizure

SCN1A SCN2A SCN9A

2.06e-0415413HP:0007207
HumanPhenoDysgenesis of the hippocampus

SCN1A SCN2A SCN9A

2.52e-0416413HP:0025101
HumanPhenoComplex febrile seizure

SCN1A SCN2A SCN9A

2.52e-0416413HP:0011172
HumanPhenoBradykinesia

PTPA PDE8B SCN1A SCN2A SCN9A ADGRV1

2.87e-04116416HP:0002067
HumanPhenoFocal motor status epilepticus

SCN1A SCN2A SCN9A

3.04e-0417413HP:0032663
HumanPhenoVisually-induced seizure

SCN1A SCN2A SCN9A

3.63e-0418413HP:0020216
HumanPhenoAmyotrophy involving the shoulder musculature

FKTN CAPN3

3.75e-044412HP:0001465
HumanPhenoLimitation of joint mobility

SCN1A HS2ST1 SCN2A CAPN3 SCN9A FGFR2 OCRL ADGRV1 F8 RYR1 SMAD4

4.36e-044324111HP:0001376
HumanPhenoAtypical absence seizure

SCN1A SCN2A SCN9A ADGRV1

4.62e-0446414HP:0007270
MousePhenoincreased susceptibility to induced morbidity/mortality

SCN1A C4A C4B ADGRV1 ATP2A2 TNXB F8 RYR1 RYR2 TIPARP

4.05e-063466510MP:0009763
MousePhenotranslucent skin

FGFR2 RYR1 CHUK

4.20e-0515653MP:0001201
MousePhenoabnormal susceptibility to induced morbidity/mortality

SCN1A C4A C4B ADGRV1 ATP2A2 TNXB F8 RYR1 RYR2 TIPARP

5.82e-054716510MP:0020148
MousePhenoabnormal heart septum morphology

CCP110 IGF2R LRP1 TRAPPC10 ATP11A FGFR2 ATP2A2 RYR1 RYR2

7.21e-05388659MP:0006113
MousePhenoabnormal breathing pattern

DPP4 IGF2R SCN1A SCN2A SCN10A PPME1 FGFR2 RYR1

7.67e-05303658MP:0001951
MousePhenoomphalocele

CCP110 LRP1 RYR1 CHUK

1.05e-0453654MP:0003052
MousePhenodecreased paired-pulse ratio

SCN1A RYR2

1.27e-044652MP:0014253
MousePhenoabnormal induced morbidity/mortality

DPP4 SCN1A HRH1 C4A C4B ADGRV1 ATP2A2 TNXB F8 RYR1 RYR2 TIPARP

1.29e-047376512MP:0001657
MousePhenoabnormal parietal endoderm morphology

FKTN CTDNEP1 SMAD4

1.81e-0424653MP:0011187
MousePhenopremature bone ossification

SAMD1 IGF2R FGFR2

2.31e-0426653MP:0003416
MousePhenodecreased spleen germinal center number

GALNT1 C4A C4B

2.31e-0426653MP:0008482
MousePhenoneonatal lethality

CCP110 IGF2R PTPRS SCN1A HS2ST1 SCN9A PRDM12 PPME1 FGFR2 ATP2A2 RYR1 CHUK

2.73e-047996512MP:0002058
MousePhenodecreased susceptibility to viral infection

DPP4 C4A C4B APOBEC3B APOBEC3F

2.84e-04125655MP:0002410
MousePhenodecreased susceptibility to Coronaviridae infection

DPP4 C4A C4B

2.89e-0428653MP:0020950
MousePhenoabnormal Reichert's membrane thickness

FKTN SMAD4

3.16e-046652MP:0012094
MousePhenoskeletal muscle degeneration

SAMD1 CAPN3 RYR1

3.56e-0430653MP:0009415
MousePhenoabnormal action potential

SCN1A SCN2A SCN9A SCN10A RYR2

3.78e-04133655MP:0005402
MousePhenoperinatal lethality, complete penetrance

CCP110 IGF2R HS2ST1 SCN2A SCN9A LRP1 PRDM12 PPME1 FGFR2 RYR1 CHUK

4.00e-047126511MP:0011089
MousePhenoventricular fibrillation

SCN1A RYR2

4.40e-047652MP:0006110
MousePhenoabnormal paired-pulse ratio

SCN1A RYR2

4.40e-047652MP:0014252
MousePhenoabnormal interventricular groove morphology

FGFR2 RYR1

4.40e-047652MP:0004032
MousePhenoabnormal presphenoid bone morphology

FGFR2 TIPARP CHUK

4.74e-0433653MP:0004448
MousePhenothick interventricular septum

IGF2R ATP2A2 RYR2

4.74e-0433653MP:0010724
MousePhenoabnormal respiratory function

DPP4 IGF2R SCN1A SCN2A SCN10A PPME1 FGFR2 RYR1

5.00e-04399658MP:0002327
MousePhenoabnormal abdominal wall morphology

CCP110 LRP1 RYR1 CHUK

5.67e-0482654MP:0003257
MousePhenoperinatal lethality

CCP110 IGF2R PTPRS SCN1A HS2ST1 SCN2A SCN9A LRP1 PRDM12 PPME1 FGFR2 ATP2A2 RYR1 CHUK

5.73e-0411306514MP:0002081
MousePhenostomach epithelial hyperplasia

ATP2A2 SMAD4

5.85e-048652MP:0005493
DomainNa_channel_asu

SCN1A SCN2A SCN3A SCN9A SCN10A

3.57e-1010825IPR001696
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN9A SCN10A

3.57e-1010825IPR010526
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN9A SCN10A

3.57e-1010825PF06512
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN9A

5.14e-096824PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN9A

5.14e-096824IPR024583
DomainIon_trans_dom

SCN1A SCN2A SCN3A SCN9A SCN10A RYR1 RYR2

6.83e-07114827IPR005821
DomainIon_trans

SCN1A SCN2A SCN3A SCN9A SCN10A RYR1 RYR2

6.83e-07114827PF00520
DomainChannel_four-helix_dom

SCN1A SCN2A SCN3A SCN9A SCN10A

5.05e-0657825IPR027359
Domain-

SCN1A SCN2A SCN3A SCN9A SCN10A

5.05e-06578251.20.120.350
DomainPDEase_PDE8

PDE8A PDE8B

1.90e-052822IPR013938
DomainIQ_motif_EF-hand-BS

SCN1A SCN2A SCN3A SCN9A SCN10A

4.73e-0590825IPR000048
DomainIQ

SCN1A SCN2A SCN3A SCN9A SCN10A

5.54e-0593825PS50096
DomainRyanrecept_TM4-6

RYR1 RYR2

5.70e-053822IPR009460
DomainRyR

RYR1 RYR2

5.70e-053822PF02026
DomainRyanodine_rcpt

RYR1 RYR2

5.70e-053822IPR003032
DomainCu-oxidase

CP F8

5.70e-053822PF00394
DomainRR_TM4-6

RYR1 RYR2

5.70e-053822PF06459
DomainRyan_recept

RYR1 RYR2

5.70e-053822IPR013333
DomainCu-oxidase

CP F8

5.70e-053822IPR001117
DomainFAM47

FAM47C FAM47B

1.14e-044822PF14642
DomainCu-oxidase_2

CP F8

1.14e-044822IPR011706
DomainFAM47

FAM47C FAM47B

1.14e-044822IPR032743
DomainCu-oxidase_2

CP F8

1.14e-044822PF07731
DomainCu_oxidase_CS

CP F8

1.89e-045822IPR033138
DomainAnaphylatoxin_comp_syst

C4A C4B

1.89e-045822IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

1.89e-045822IPR001840
DomainCu-oxidase_3

CP F8

1.89e-045822IPR011707
DomainMULTICOPPER_OXIDASE1

CP F8

1.89e-045822PS00079
DomainCu-oxidase_3

CP F8

1.89e-045822PF07732
DomainEF-hand-dom_pair

PPP2R3A SCN1A SCN3A CAPN3 SCN9A RYR1 RYR2

2.67e-04287827IPR011992
DomainIQ

SCN1A SCN3A SCN9A SCN10A

2.68e-0471824PF00612
DomainRIH_assoc

RYR1 RYR2

2.82e-046822PF08454
DomainRIH_assoc-dom

RYR1 RYR2

2.82e-046822IPR013662
DomainRIH_dom

RYR1 RYR2

2.82e-046822IPR000699
DomainIns145_P3_rcpt

RYR1 RYR2

2.82e-046822IPR014821
DomainRyanodine_recept-rel

RYR1 RYR2

2.82e-046822IPR015925
Domain-

RYR1 RYR2

2.82e-0468221.25.10.30
DomainRYDR_ITPR

RYR1 RYR2

2.82e-046822PF01365
DomainIns145_P3_rec

RYR1 RYR2

2.82e-046822PF08709
DomainCu_oxidase_Cu_BS

CP F8

2.82e-046822IPR002355
DomainANATO

C4A C4B

3.94e-047822SM00104
DomainANATO

C4A C4B

3.94e-047822PF01821
DomainANAPHYLATOXIN_2

C4A C4B

3.94e-047822PS01178
DomainANAPHYLATOXIN_1

C4A C4B

3.94e-047822PS01177
DomainAnaphylatoxin/fibulin

C4A C4B

3.94e-047822IPR000020
DomainEF-hand_8

CAPN3 RYR1 RYR2

4.42e-0434823PF13833
DomainIQ

SCN1A SCN2A SCN3A SCN9A

4.44e-0481824SM00015
DomainThiol-ester_cl

C4A C4B

5.24e-048822PF10569
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

5.24e-048822IPR019565
DomainMacrogloblnA2_CS

C4A C4B

5.24e-048822IPR019742
DomainA2M_N

C4A C4B

8.38e-0410822PF01835
DomainMIR

RYR1 RYR2

8.38e-0410822PS50919
DomainMIR

RYR1 RYR2

8.38e-0410822PF02815
DomainMIR

RYR1 RYR2

8.38e-0410822SM00472
DomainA2M_N

C4A C4B

8.38e-0410822IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

8.38e-0410822IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

8.38e-0410822PS00477
DomainA2M

C4A C4B

8.38e-0410822PF00207
DomainMIR_motif

RYR1 RYR2

8.38e-0410822IPR016093
DomainA2M_N_2

C4A C4B

8.38e-0410822IPR011625
DomainA2M_comp

C4A C4B

8.38e-0410822IPR011626
DomainA2M_N_2

C4A C4B

8.38e-0410822PF07703
DomainA2M_recep

C4A C4B

8.38e-0410822PF07677
DomainA2M_comp

C4A C4B

8.38e-0410822PF07678
DomainMacroglobln_a2

C4A C4B

8.38e-0410822IPR001599
DomainKRAB

ZNF383 ZNF789 ZNF566 ZNF189 ZNF324 ZNF324B ZNF554

9.94e-04358827PS50805
DomainKRAB

ZNF383 ZNF789 ZNF566 ZNF189 ZNF324 ZNF324B ZNF554

9.94e-04358827PF01352
DomainKRAB

ZNF383 ZNF789 ZNF566 ZNF189 ZNF324 ZNF324B ZNF554

1.18e-03369827SM00349
DomainKRAB

ZNF383 ZNF789 ZNF566 ZNF189 ZNF324 ZNF324B ZNF554

1.20e-03370827IPR001909
DomainAPOBEC_N

APOBEC3B APOBEC3F

1.22e-0312822PF08210
DomainCalpain_III

CAPN3 CAPN5

1.22e-0312822IPR022683
Domaincalpain_III

CAPN3 CAPN5

1.22e-0312822SM00720
DomainC2_III

CAPN3 CAPN5

1.22e-0312822IPR033883
DomainAPOBEC_N

APOBEC3B APOBEC3F

1.22e-0312822IPR013158
DomainCalpain_domain_III

CAPN3 CAPN5

1.44e-0313822IPR022682
DomainCalpain_III

CAPN3 CAPN5

1.44e-0313822PF01067
Domain-

CP F8

1.67e-03148222.60.40.420
DomainCalpain_cysteine_protease

CAPN3 CAPN5

1.67e-0314822IPR022684
DomainAPOBEC/CMP_deaminase_Zn-bd

APOBEC3B APOBEC3F

1.67e-0314822IPR016192
DomainCysPc

CAPN3 CAPN5

1.93e-0315822SM00230
DomainPeptidase_C2_calpain_cat

CAPN3 CAPN5

1.93e-0315822IPR001300
DomainPeptidase_C2

CAPN3 CAPN5

1.93e-0315822PF00648
DomainCALPAIN_CAT

CAPN3 CAPN5

1.93e-0315822PS50203
DomainCYT_DCMP_DEAMINASES_2

APOBEC3B APOBEC3F

1.93e-0315822PS51747
DomainC345C

C4A C4B

2.48e-0317822SM00643
DomainCytidine_deaminase-like

APOBEC3B APOBEC3F

2.48e-0317822IPR016193
DomainCYT_DCMP_DEAMINASES_1

APOBEC3B APOBEC3F

2.48e-0317822PS00903
DomainCMP_dCMP_Zn-bd

APOBEC3B APOBEC3F

2.48e-0317822IPR002125
DomainTerpenoid_cyclase/PrenylTrfase

C4A C4B

2.78e-0318822IPR008930
DomainNTR

C4A C4B

3.10e-0319822PF01759
DomainPDEase

PDE8A PDE8B

3.10e-0319822IPR023088
DomainNetrin_module_non-TIMP

C4A C4B

3.10e-0319822IPR018933
DomainPDEase_I

PDE8A PDE8B

3.79e-0321822PF00233
DomainPDEASE_I

PDE8A PDE8B

3.79e-0321822PS00126
DomainPDEase_CS

PDE8A PDE8B

3.79e-0321822IPR023174
DomainCupredoxin

CP F8

4.15e-0322822IPR008972
Domain-

PDE8A PDE8B

4.15e-03228221.10.1300.10
PathwayREACTOME_CARDIAC_CONDUCTION

SCN1A SCN2A SCN3A SCN9A SCN10A ATP2A2 RYR1 RYR2

1.96e-07130688M27454
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN1A SCN2A SCN3A SCN9A SCN10A

3.47e-0731685M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN2A SCN3A SCN9A SCN10A

4.09e-0732685M27455
PathwayREACTOME_MUSCLE_CONTRACTION

SCN1A SCN2A SCN3A SCN9A SCN10A ATP2A2 RYR1 RYR2

5.68e-06203688M5485
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN2A SCN3A SCN9A SCN10A

4.36e-13684523652591
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN2A SCN3A SCN9A SCN10A

9.11e-12984516382098
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN2A SCN3A SCN9A SCN10A

9.23e-111384515123669
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN2A SCN3A SCN9A

1.58e-1058448812438
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

DPP4 PTPRS LRP1 CP C4A ADAMTS13 SERPINA6 TNXB F8

1.30e-0825784916335952
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN3A SCN9A

1.36e-08384319284629
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN3A SCN9A

1.36e-08384333895391
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN2A SCN3A

1.36e-08384323859570
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN2A SCN3A

1.36e-08384312610651
Pubmed

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.

SCN3A SCN9A SCN10A

1.36e-08384319699781
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN2A SCN3A

1.36e-08384318784617
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN2A SCN3A

1.36e-08384317544618
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN2A SCN3A

1.36e-08384314973256
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN3A

5.43e-08484317537961
Pubmed

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.

SCN1A SCN9A SCN10A

5.43e-08484322260870
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN2A SCN3A

5.43e-08484335801810
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN3A

5.43e-08484335031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN3A

5.43e-08484329578003
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN1A SCN2A SCN3A

5.43e-0848438974318
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN1A SCN2A SCN3A

1.35e-0758431679748
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN1A SCN2A SCN3A

1.35e-07584324337656
Pubmed

Androgen-dependent hereditary mouse keratoconus: linkage to an MHC region.

C4A C4B TNXB

2.70e-07684311773012
Pubmed

Pain without nociceptors? Nav1.7-independent pain mechanisms.

SCN3A SCN9A SCN10A

4.72e-07784324440715
Pubmed

Significant determinants of mouse pain behaviour.

SCN3A SCN9A SCN10A

7.54e-07884325101983
Pubmed

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.

ATP2A2 RYR1 RYR2

7.54e-07884311784029
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

ATP2A2 RYR1 RYR2

7.54e-07884319033399
Pubmed

Molecular genetics of the human MHC complement gene cluster.

C4A C4B TNXB

7.54e-07884310072631
Pubmed

Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.

SCN3A SCN9A SCN10A

1.13e-0698438854872
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN2A SCN3A

1.13e-06984315746173
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

SCN1A SCN3A SCN9A SCN10A ATP2A2 RYR2

1.15e-0613984616985003
Pubmed

Organizations and gene duplications of the human and mouse MHC complement gene clusters.

C4A C4B TNXB

2.21e-061184310686478
Pubmed

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.

ATP2A2 RYR1 RYR2

2.94e-061284319095005
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN2A SCN3A

2.94e-061284330175250
Pubmed

Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.

SCN1A SCN2A SCN3A

2.94e-06128438169823
Pubmed

Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.

LRP1 CP C4A APOA4

3.99e-064484431273033
Pubmed

MED12 regulates a transcriptional network of calcium-handling genes in the heart.

ATP2A2 RYR1 RYR2

4.85e-061484328724790
Pubmed

Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

CP C4A C4B SERPINA6

5.22e-064784414760718
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF383 ZNF789 ZNF566 ZNF324 ZNF324B ZNF554

5.31e-0618184637372979
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

5.76e-06284222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

5.76e-06284216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

5.76e-06284215998580
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

5.76e-06284219062096
Pubmed

cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis.

PDE8A PDE8B

5.76e-06284222232524
Pubmed

Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.

SCN2A SCN3A

5.76e-06284220346423
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

5.76e-06284219933335
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

5.76e-0628422459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

5.76e-06284217645767
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

5.76e-06284212207352
Pubmed

Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

SCN1A SCN2A

5.76e-06284210827969
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

5.76e-06284227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

5.76e-06284222387014
Pubmed

Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.

SCN1A SCN2A

5.76e-06284219694741
Pubmed

Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.

SCN2A SCN3A

5.76e-06284211245985
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

5.76e-06284223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

5.76e-06284223918728
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

5.76e-0628423037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

5.76e-06284211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

5.76e-0628424216347
Pubmed

The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland.

PDE8A PDE8B

5.76e-06284221187369
Pubmed

Mercury metallation of the copper protein azurin and structural insight into possible heavy metal reactivity.

CP F8

5.76e-06284225265377
Pubmed

Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE.

LRP1 F8

5.76e-06284227794518
Pubmed

Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.

RYR1 RYR2

5.76e-06284217259277
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

5.76e-0628426950384
Pubmed

Differential expression of two sodium channel subtypes in human brain.

SCN1A SCN2A

5.76e-0628421317301
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

5.76e-0628428660986
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

5.76e-0628428428773
Pubmed

A common polymorphism decreases LRP1 mRNA stability and is associated with increased plasma factor VIII levels.

LRP1 F8

5.76e-06284228431990
Pubmed

Proteolytic cleavage of factor VIII heavy chain is required to expose the binding-site for low-density lipoprotein receptor-related protein within the A2 domain.

LRP1 F8

5.76e-06284216839343
Pubmed

Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.

SCN2A SCN3A

5.76e-06284223016767
Pubmed

Ryanodine receptor oligomeric interaction: identification of a putative binding region.

RYR1 RYR2

5.76e-06284214722100
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

5.76e-06284224638111
Pubmed

Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.

LRP1 F8

5.76e-06284225903134
Pubmed

Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

SCN2A SCN3A

5.76e-06284227153334
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

5.76e-06284221345967
Pubmed

Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.

SCN1A SCN3A

5.76e-06284224990319
Pubmed

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

SCN3A SCN9A

5.76e-06284225172946
Pubmed

Structural and functional interactions within ryanodine receptor.

RYR1 RYR2

5.76e-06284226009179
Pubmed

Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.

SCN1A SCN2A

5.76e-06284231439038
Pubmed

Ocular manifestations among patients with congenital insensitivity to pain due to variants in PRDM12 and SCN9A genes.

SCN9A PRDM12

5.76e-06284236111846
Pubmed

Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.

RYR1 RYR2

5.76e-06284232899693
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

5.76e-0628422572548
Pubmed

The complement component C4 of mammals.

C4A C4B

5.76e-0628422302180
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

5.76e-06284222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

5.76e-06284218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

5.76e-06284229080553
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

5.76e-0628426589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

5.76e-06284225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

5.76e-06284217728371
Pubmed

Structure and organization of the C4 genes.

C4A C4B

5.76e-0628426149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

5.76e-0628426149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

5.76e-06284212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

5.76e-0628423542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

5.76e-0628422387317
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

5.76e-06284216908004
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

5.76e-0628427365238
Pubmed

Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.

SCN1A SCN2A

5.76e-06284215249644
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

5.76e-0628427391573
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

5.76e-06284217971360
Pubmed

Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.

SCN1A SCN3A

5.76e-06284227690330
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

5.76e-06284229928053
InteractionCACNA1D interactions

SCN1A SCN9A SCN10A FGFR2 RYR2

3.94e-0824825int:CACNA1D
Cytoband2q24.3

DPP4 SCN1A SCN2A

3.25e-06168432q24.3
CytobandEnsembl 112 genes in cytogenetic band chr2q24

DPP4 SCN1A SCN2A SCN3A SCN9A

3.88e-06127845chr2q24
Cytoband2q24

SCN3A SCN9A

1.80e-04118422q24
Cytoband18q12.1

GALNT1 DSG1

1.04e-032684218q12.1
CytobandXp21.1

FAM47C FAM47B

1.79e-0334842Xp21.1
Cytoband9q34

PTPA ADAMTS13

4.45e-03548429q34
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN2A SCN3A SCN9A SCN10A

5.45e-1196351203
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR1 RYR2

3.58e-053632287
GeneFamilyProtein phosphatase 2 modulatory subunits

PTPA PPME1

1.19e-0456321265
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

4.23e-0496321234
GeneFamilyApolipoprotein B mRNA editing enzyme catalytic subunits

APOBEC3B APOBEC3F

7.71e-0412632406
GeneFamilyC2 domain containing|Calpains

CAPN3 CAPN5

1.22e-0315632975
GeneFamilyPolypeptide N-acetylgalactosaminyltransferases

GALNT1 GALNT4

2.18e-0320632433
GeneFamilyPhosphodiesterases

PDE8A PDE8B

3.14e-0324632681
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF383 ZNF789 ZNF566 ZNF189 ZNF324 PRDM12 ZNF324B ZNF554

3.35e-0371863828
GeneFamilyComplement system|Sushi domain containing

C4A C4B

6.98e-0336632492
GeneFamilyGlycosyltransferase family 6|Blood group antigens

C4A C4B

7.36e-0337632454
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FRY ZNF566 HRH1 ZNF324B SRCAP ZNF554

4.76e-07154846ba55a63cfa5e0fb9dfec794f80078a2f0d03d0ad
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 SCN3A SCN9A C4B ADGRV1 RYR2

8.20e-0716984612bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

PTPN5 FRY SCN2A SCN3A SCN9A RYR2

1.62e-061908466e92c78799f34b31d098854503c796edb0dc7f80
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A SCN9A SCN10A ADGRV1 SERPINA6

8.16e-0614584596712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCelldroplet-Liver-Npc-21m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C4A ATP11A TNXB GALNT4

9.98e-0671844cf4c8715c2bd77fc86e45cc01bcc7aa6044e091d
ToppCell3'_v3-blood-Lymphocytic_T_CD8-Trm_gut_CD8|blood / Manually curated celltypes from each tissue

FNDC7 CAPN3 ADAMTS13 F8 ZNF554

1.03e-051528451fea735321da6db6d2cd3f83d2f7fac72d44904d
ToppCelldroplet-Lung-nan-21m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPP4 FNDC7 HRH1 SERPINA6 RYR1

1.76e-0517084571c52fadecc6b4bfe98692b266adaa1406f6d56d
ToppCelldroplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FKTN PTPRS HRH1 RYR1 TMEM229B

1.86e-05172845422d311bba2dd5d8bece4e96ee8c86e78086b62d
ToppCelldroplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FKTN PTPRS HRH1 RYR1 TMEM229B

1.86e-051728451abb6fbb28c8aff384540493d0f70eeacaa751f4
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPP4 PTPRS SCN2A LRP1 TNXB

1.97e-051748451d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK5 SCN3A SCN9A TNXB F8

2.20e-05178845ad3de3e03a401dac64431a541899445262246347
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK5 SCN3A SCN9A TNXB F8

2.51e-051838454d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK5 PTPRS LRP1 TNXB RYR2

2.51e-051838457eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 SCN2A SCN9A ADGRV1 RYR2

2.57e-051848452cbed6462fea2622871bb7e49b0df3d984239281
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

DPP4 SCN1A ATP11A FGFR2 ADGRV1

2.57e-05184845369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 SCN2A SCN9A ADGRV1 RYR2

2.57e-05184845ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 SCN2A SCN9A ADGRV1 RYR2

2.57e-051848452b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Brain_Non-Myeloid-Cerebellum|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FNDC7 SCN2A RYR2 TMEM229B GABRA6

2.64e-05185845c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK5 SCN3A SCN9A TNXB F8

2.71e-0518684540070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SCN2A SCN10A LRP1 ADGRV1 RYR2

2.71e-0518684523b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A KLHDC8A SCN2A RYR2 TMEM229B

2.78e-051878457b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DPP4 SCN1A ATP11A FGFR2 ADGRV1

2.78e-051878455df9e1f5ca32217af255e76e6fb5afa346337811
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A HRH1 ATP11A ADGRV1 SNX29

2.85e-05188845af740fa78542438fdff627ea1f74f4eee43316be
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

DOCK5 SCN1A ATP11A FGFR2 ADGRV1

2.85e-05188845707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D231|Adult / Lineage, Cell type, age group and donor

DPP4 SCN1A ATP11A FGFR2 ADGRV1

2.93e-05189845dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCellfacs-Lung-18m-Mesenchymal|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SCN3A LRP1 CP C4B TNXB

2.93e-05189845bdf8db938aa0863c4fed6fa99dcffd63c8c20c31
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FRY SCN9A FGFR2 ADGRV1 ARAP2

2.93e-051898457659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SCN3A LRP1 CP C4B TNXB

2.93e-0518984540cbd679dc0548bf5207e1b033c0597886ad6fe1
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SCN3A LRP1 CP C4B TNXB

3.08e-0519184544a9a6768084dafc641ad455b65862bfd4cc0cb9
ToppCellfacs-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN3A ITPRIP CP ANKRD6 F8

3.08e-0519184548823a97c38263f2c6e58348214f5b62773a6368
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

DPP4 SCN1A ATP11A FGFR2 ADGRV1

3.08e-05191845276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN3A ITPRIP CP ANKRD6 F8

3.08e-051918450eedc66e967b1837ce2c14f8c14b3c1eba868c76
ToppCellPND28-Mesenchymal-Mesenchymal_structural|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN3A LRP1 CP C4B TNXB

3.23e-05193845ec81c1afdae2e0433a22c8c1fa1c6232526ff7e7
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK5 SCN3A SCN9A TNXB F8

3.23e-05193845040f6bb42aa41d0921371fdda1cc0912c4fe1930
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK5 SCN3A SCN9A TNXB F8

3.23e-05193845e468287c8b30c56d1de65e8347ade233ba6cf584
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN3A LRP1 CP C4B TNXB

3.23e-0519384530481fb01c7acf85beae10213f038da86bed6777
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

FRY PPP2R3A PDE8B ATP2A2 RYR2

3.32e-05194845c3535f7cc0076653c72db582047cff053c322397
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PDE8B CP C4A FGFR2 ADGRV1

3.57e-0519784501e9505d947e5a5f005d1eab96301f84fc194809
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

SCN1A CP ATP11A FGFR2 ADGRV1

3.57e-051978451a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRY SCN1A SCN2A SCN3A RYR2

3.65e-05198845c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellLAM-Endothelial-LymEndo|Endothelial / Condition, Lineage and Cell class

DOCK5 GALNT1 SCN3A SCN9A TNXB

3.65e-05198845ba64b1c95dfaa995045239d412e725596f6c482e
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRY SCN1A SCN2A SCN3A RYR2

3.65e-051988456d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRY SCN1A SCN2A SCN3A RYR2

3.65e-051988454ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellParenchyma_COVID-19-Endothelial-TX-Lymphatic|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

DOCK5 SCN3A SCN9A TNXB F8

3.74e-0519984588f33b8dcd837abfa1d12c28719e073a7da6e979
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK5 SCN1A ATP11A FGFR2 ADGRV1

3.74e-051998458587bd98de7767a575088afbea07a1feb4516b9b
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DOCK5 SCN3A SCN9A TNXB F8

3.74e-0519984564b19aff72e2a109cb5857cb248bd4712dd49b43
ToppCellSepsis-Bac-SEP-Myeloid-tDC|Bac-SEP / Disease, condition lineage and cell class

ZNF789 DNAH10 CAPN3 SCN9A ZNF324B

3.74e-05199845a2be40d367338d32348a6906c8475aa3b544a0f7
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DOCK5 SCN3A SCN9A TNXB F8

3.74e-051998452b9e1e069b36b3a61cc3e384f4523687b0e03905
ToppCellILEUM-non-inflamed-(8)_Fibroblast-(8)_Fibroblasts|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

LRP1 CP CAPN5 FGFR2 TNXB

3.74e-0519984556d72da6a5fab9cbb2975fe6f87a631debaba6a8
ToppCellfacs-Brain_Non-Myeloid-Hippocampus|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCP110 GALNT1 PDE8A EIF3B ARAP2

3.83e-05200845fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

FRY SCN1A SCN2A SCN3A SCN9A

3.83e-05200845f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

FRY SCN1A SCN2A SCN3A SCN9A

3.83e-05200845cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

FRY SCN1A SCN2A SCN3A SCN9A

3.83e-05200845c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-AT2-2|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

DPP4 SCN1A ATP11A FGFR2 ADGRV1

3.83e-05200845acc771a902cf2f060c3eb9aedb72a256f5778a6c
ToppCellParenchyma_COVID-19-Epithelial-TX-AT2-2|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

DPP4 SCN1A ATP11A FGFR2 ADGRV1

3.83e-05200845ceb613ac6cdf0e3e6bb3f04d89034e18a524cefb
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

FRY SCN1A SCN2A SCN3A SCN9A

3.83e-052008454fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

FRY SCN1A SCN2A SCN3A SCN9A

3.83e-05200845310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-AT2-2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DPP4 SCN1A ATP11A FGFR2 ADGRV1

3.83e-05200845eb44d1f80ecaac3a022cd04ab16dc36151e45488
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

FRY SCN1A SCN2A SCN3A SCN9A

3.83e-05200845961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Sla|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CAPN3 ZNF189 ANKRD6 RYR1

1.14e-04132844ddebc0b233fdbb73ceb70187945bbed8fd273f2a
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Tpbg_(eccentric_SPN,_dSPN-like_markers)|Striatum / BrainAtlas - Mouse McCarroll V32

SCN10A APOA4 ADAMTS13

1.15e-04508439a54cd5a55ef53f7a8b43fe76c4e0e47b44b8c71
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Tpbg_(eccentric_SPN,_dSPN-like_markers)-|Striatum / BrainAtlas - Mouse McCarroll V32

SCN10A APOA4 ADAMTS13

1.15e-0450843cd5e2a8f4fa4a31d0c7a74d5826485e42b3908f7
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FKTN CP ATP11A FGFR2

1.17e-041338445bf5e654653e2c340891f51e3f2a30441b7b6b2b
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Serpinb1a|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DOCK5 PDE8A FGFR2 ADGRV1

1.31e-04137844ca8fdbe66a854e6283b22179ec9359ea9e86cd8e
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE|Hippocampus / BrainAtlas - Mouse McCarroll V32

DOCK5 CCP110 PDE8A ADGRV1

1.31e-041378445e97480f014f1d9267e8126f1d0e58acd22f36aa
ToppCellprimary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Serpinb1a|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DOCK5 PDE8A FGFR2 ADGRV1

1.39e-04139844789edd3c98e7c5c1cc402c780fded9a9dfd1dfb8
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DPP4 LRP1 CHID1 FGFR2

1.51e-04142844d52da766e031f7409eb5a7a9fa88f48e14a79d8b
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DPP4 LRP1 CHID1 FGFR2

1.51e-04142844a05b320cf182b2aaf18df7c40045dc65b659bf20
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-13|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDE8B SCN3A ADAMTS13 SNX29

1.59e-04144844b2a9f3b5dd46d27689467f4a5fd717cd5827821f
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|368C / Donor, Lineage, Cell class and subclass (all cells)

ZNF566 ZNF324B SRCAP ZNF554

1.72e-041478443ed5b020ce1f1277917d79ef1f7da53fa474e8db
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK5 LRP1 CP RYR1

1.96e-0415284482a493ffb2f1704cd6f68a82d970fe12f537d20e
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CP SRCAP F8 APOBEC3B

2.01e-04153844991782d111d66e25b40319d4e6dea40f2c2c0805
ToppCellfacs-Liver|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CP C4B APOA4 SERPINA6

2.27e-04158844ea7db6bd9742153ceb6e444892a6d1df9c7fcc96
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZNF566 OCRL TNXB F8

2.33e-041598441472536eea61d4f13033efe42f128bae1614fa74
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIAA0825 LSM11 ANKRD6 TMEM229B

2.33e-04159844f7bccfeffa737f151417bf52ea45111b0957bce9
ToppCellsevere_COVID-19-pDC|severe_COVID-19 / disease group, cell group and cell class (v2)

PPP2R3A PTPRS SCN9A RYR1

2.33e-04159844ea5088d27e42b8850455764d53b757ea8d8f14bc
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DNAH10 SCN9A SCN10A ADGRV1

2.50e-04162844bf886e22ff2a20353499004b53f25fb9e6574896
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CP APOA4 ATP11A ADAMTS13

2.50e-04162844de0fde4310a56dc96bfc134c44d104993526d9bc
ToppCellBac-SEP-Myeloid-tDC|Bac-SEP / Disease, Lineage and Cell Type

ZNF789 DNAH10 SCN9A ZNF324B

2.68e-041658448728f927502e56f2768b4224e9111939d3d7815a
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 C4B TNXB GABRA6

2.68e-04165844f80665b75d43f1bf6919d59fc762e7e0bac653f2
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-Granular_Neuron_CB_Gabra6|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN5 KLHDC8A SCN2A TMEM229B

2.74e-04166844ec7bd549bda5f18aca8aebce5ba479a81abbbeda
ToppCelldroplet-Lung-LUNG-1m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPP4 FNDC7 HRH1 RYR1

2.74e-04166844c215c4aede38d355d35fd26cd7ef2c19efecd0e6
ToppCellVE-Treg-exh_CD4|VE / Condition, Cell_class and T cell subcluster

CCP110 PDE8A OCRL ZNF324B

2.80e-041678441036ac1ef9440612500137af9d1929672b077e4d
ToppCelldroplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPP4 FNDC7 HRH1 RYR1

2.87e-0416884499148986aa5628f67d85258c171b254be77a071c
ToppCellmild_COVID-19_(asymptomatic)-pDC|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

DPP4 ZNF789 PTPRS SCN9A

2.87e-04168844968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCell343B-Lymphocytic-NK_cells-NK_cell_B0|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

DPP4 PTPRS SCN9A CTDNEP1

2.93e-0416984489b5452e0d8d058648a1d2659f1611fd6aebc6b6
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPP4 PDE8A LRP1 TNXB

2.93e-04169844bb43abad2c049b7f4d307737347290e01b3339a3
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPP4 PDE8A LRP1 TNXB

2.93e-041698445f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPP4 PDE8A LRP1 TNXB

2.93e-041698448bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN3A HRH1 RYR1 TMEM229B

3.14e-041728447fb31ccbcd0204c3612986a6bc20d57ed6825e9c
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN3A HRH1 RYR1 TMEM229B

3.14e-041728442a4614b3d25e8c6b095e6992d8ca35371dcdb5e1
ToppCellfacs-Marrow-T-cells-24m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRS HRH1 RYR1 TMEM229B

3.21e-04173844ca3d2a9562734f76127e3e7d54c10b63e95141bb
ToppCellfacs-Marrow-T-cells-24m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRS HRH1 RYR1 TMEM229B

3.21e-0417384419a9e10885173d7712996be8660a3a5a7a9aa39f
ToppCellCOVID-19-Heart-Neuronal|Heart / Disease (COVID-19 only), tissue and cell type

DOCK5 IRS4 SCN9A ARAP2

3.21e-041738446fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ZNF566 OCRL TNXB F8

3.21e-041738447e2149205e119cec4f5099c83c85d1e13470137a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK5 GALNT1 TNXB RSPH10B

3.35e-041758449a96a946db731ba24c9be34bedebf1f4a1372b9e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK5 GALNT1 TNXB RSPH10B

3.35e-0417584454c1f080195ad8392a095e83b56a4b54073d4c0d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK5 GALNT1 TNXB RSPH10B

3.35e-041758442b51406a2c2daa13ab4ed283ede038cd11d9e641
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PDE8B CP CAPN5 TMEM229B

3.50e-04177844a235ff4f37a7622216526191efc4832fb8ed6957
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A SCN3A OCRL TIPARP

3.50e-041778441dc69c661e70e7e22bd9d7cf953eb638da9fd43c
Druglamotrigine

PTPN5 SCN2A SCN3A SCN9A SCN10A RYR1 RYR2

2.06e-07116827CID000003878
DrugZonisamide

SCN1A SCN2A SCN3A SCN9A

3.59e-0717824DB00909
DrugLMWH

LIPM HS2ST1 LRP1 CHPF2 C4A APOA4 ADAMTS13 FGFR2 TNXB F8 RYR1 RYR2 IMPG2

6.78e-076638213CID000000772
DrugAPETx1, Anthopleura elegantissima

SCN2A SCN3A SCN10A

8.94e-076823ctd:C475726
Drugfenpropathrin

SCN2A SCN3A SCN10A

8.94e-076823ctd:C044267
Drugphenytoin

SCN2A SCN3A SCN9A SCN10A CAPN5 FGFR2 RYR1 RYR2

1.25e-06219828CID000001775
Drugdihydrochloride

DSG1 SCN3A SCN9A SCN10A HRH1 CP APOA4

1.74e-06159827CID000070978
Drug2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

SCN2A SCN3A SCN10A

2.49e-068823ctd:C489827
Drugnefopam

SCN3A SCN9A SCN10A HRH1

2.57e-0627824CID000004450
Drugarabinosyladenine

DPP4 PTPA IGF2R PDE8A PDE8B CAPN3 C4A ATP11A ATP2A2 TNXB F8 RYR1 RYR2

3.17e-067628213CID000000191
Drugolanzapine

PDE8B HRH1 CP C4A C4B APOA4

5.01e-06121826ctd:C076029
Drugflecainide

SCN3A SCN9A SCN10A RYR1 RYR2

5.79e-0671825CID000003355
Drug1, 3-diallylurea

SCN3A SCN9A SCN10A ATP2A2 TIPARP

7.10e-0674825CID000074537
Drugbenzocaine

SCN2A SCN3A SCN9A SCN10A

9.43e-0637824CID000002337
DrugTetracaine

SCN9A SCN10A RYR1

9.68e-0612823ctd:D013748
Drug4-hydroxybutyl acrylate

SCN2A F8

1.28e-052822CID000075588
DrugSodium

SCN2A SCN3A SCN9A SCN10A CP

1.32e-0584825ctd:D012964
Drugprocaine

SCN3A SCN9A SCN10A RYR1 RYR2 GABRA6

1.92e-05153826CID000004914
Druglidocaine

SCN3A SCN9A SCN10A RYR1 RYR2 GABRA6

2.47e-05160826CID000003676
DrugAC1L9KQO

DPP4 DSG1 RYR1 RYR2

2.93e-0549824CID000447335
Drugindo-1

HRH1 ADGRV1 ATP2A2 RYR1 RYR2

2.94e-0599825CID000105060
Drugisradipine

SCN3A SCN9A SCN10A RYR1 RYR2

3.08e-05100825CID000003784
Druggabapentin

SCN3A SCN9A SCN10A RYR1 RYR2 GABRA6

3.36e-05169826CID000003446
DrugScorpion Venoms

SCN2A SCN3A SCN9A

3.53e-0518823ctd:D012604
Drugcis-diammineplatinum(II

RYR1 RYR2

3.84e-053822CID000159790
Drug2-hydroxyheptanoic acid

RYR1 RYR2

3.84e-053822CID002750949
Drug8N3-cADPR

RYR1 RYR2

3.84e-053822CID000127713
DrugN-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide

SCN3A SCN9A

3.84e-053822ctd:C561228
Drug2-aminothiophenol

C4A C4B

3.84e-053822ctd:C005464
Drugaminodantrolene

RYR1 RYR2

3.84e-053822CID009570289
DrugE 4021

PDE8A PDE8B

3.84e-053822ctd:C091517
Drug2-hydroxycarbazole

RYR1 RYR2

3.84e-053822CID000093551
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR1 RYR2

3.84e-053822CID005748312
Drugriluzole

SCN3A SCN9A SCN10A RYR1 RYR2 GABRA6

3.96e-05174826CID000005070
DrugAC1L380G

ATP2A2 RYR1 RYR2

4.19e-0519823CID000084698
Drugdiprafenone

SCN3A SCN9A SCN10A

4.19e-0519823CID000071249
DrugNSC7524

SCN2A SCN3A SCN9A SCN10A RYR1 RYR2

5.08e-05182826CID000005657
Drugindo-1/AM

ADGRV1 RYR1 RYR2

5.71e-0521823CID000123918
DrugNF T

PTPA FKTN LRP1 C4A APOA4 RYR1

6.46e-05190826CID006436102
Drugpropofol

SCN3A SCN9A SCN10A RYR1 RYR2 GABRA6

6.65e-05191826CID000004943
DrugPhenytoin

SCN1A SCN2A SCN3A CP APOA4 CAPN5 FGFR2 RYR2

7.45e-05385828ctd:D010672
DrugLidocaine

SCN9A SCN10A

7.65e-054822DB00281
DrugPCB74

RYR1 RYR2

7.65e-054822CID000036218
DrugAPETx2 protein, Anthopleura elegantissima

SCN2A SCN10A

7.65e-054822ctd:C501880
DrugDeladroxone

CP SERPINA6

7.65e-054822CID000032327
Drug148504-47-6

RYR1 RYR2

7.65e-054822CID006444275
DrugSC 38249

RYR1 RYR2

7.65e-054822CID000134834
DrugAC1L1U7A

RYR1 RYR2

7.65e-054822CID000035682
Drugethacizine

SCN9A HRH1

7.65e-054822CID000107841
DrugClorocruoro Hem

C4A CAPN5 ATP2A2 RYR1 RYR2

8.30e-05123825CID003518809
DrugAustricine [10180-88-8]; Down 200; 14.2uM; HL60; HT_HG-U133A

PTPA HRH1 CAPN5 SRCAP ANKRD6 ATP2A2

8.57e-052008262157_DN
DrugPMEI

C4A TNXB APOBEC3F

8.63e-0524823CID000451928
Drugsaxitoxin

SCN2A SCN3A SCN9A SCN10A

8.95e-0565824CID000037165
DrugAC1L1CQC

SCN3A SCN9A SCN10A HRH1

8.95e-0565824CID000002012
Drugbepridil

SCN3A SCN9A SCN10A RYR1 RYR2

9.30e-05126825CID000002351
DrugAC1L320U

DOCK5 PPP2R3A PTPA

9.78e-0525823CID000133020
DrugAC1L1KOK

LRP1 HRH1 ITPRIP

9.78e-0525823CID000005588
DrugAC1NT1AF

SCN3A SCN9A SCN10A

9.78e-0525823CID005322157
DrugMulticide

PTPN5 SCN2A SCN9A

9.78e-0525823CID000024365
Drugdibucaine

SCN3A SCN9A SCN10A CP

1.07e-0468824CID000003025
DrugPirmenolum

SCN3A SCN9A SCN10A

1.10e-0426823CID000004853
Drugmethyl palmoxirate

PTPN5 SCN2A ATP2A2

1.10e-0426823CID000068593
DrugAC1L1IZE

DNAH10 SERPINA6 ATP2A2 RYR1 RYR2

1.12e-04131825CID000004799
DrugGBR 12909

SCN3A SCN9A SCN10A HRH1

1.13e-0469824CID000003455
DrugPbTx-1

SCN3A SCN9A SCN10A

1.24e-0427823CID006437089
DrugAC1L1MOZ

SCN3A SCN9A SCN10A

1.24e-0427823CID000031958
DrugKm 201

PTPN5 CP

1.27e-045822CID000089125
DrugA 68930

RYR1 RYR2

1.27e-045822ctd:C065380
Drugsodium

DPP4 SCN2A SCN3A SCN9A SCN10A CP ATP11A SERPINA6 ATP2A2 RYR1 RYR2 GABRA6

1.38e-049448212CID000000923
Drugparaben

SCN3A SCN9A SCN10A

1.38e-0428823CID000007175
Drugisoproterenol

SAMD1 PDE8A PDE8B SCN3A SCN9A SCN10A HRH1 ATP2A2 RYR1 RYR2

1.43e-046698210CID000003779
Drugdermatan sulfate

HS2ST1 CHPF2 C4A FGFR2 TNXB IMPG2

1.44e-04220826CID000032756
Drugcyfluthrin

SCN2A SCN3A SCN10A

1.54e-0429823ctd:C052570
Drugcantharidic acid

DOCK5 PPP2R3A PTPA

1.54e-0429823CID000002544
DrugBicuculline

RYR1 RYR2 GABRA6

1.54e-0429823ctd:D001640
Drugdiphenhydramine

SCN3A SCN9A SCN10A HRH1

1.56e-0475824CID000003100
DrugLOPAC

SCN2A RYR1 RYR2

1.70e-0430823CID000062696
Drugtocainide

SCN3A SCN9A SCN10A

1.70e-0430823CID000038945
DrugM-HN

PTPN5 RYR1 RYR2

1.88e-0431823CID000015450
Drugdinophysistoxin-1

DOCK5 PPP2R3A PTPA

1.88e-0431823CID006437058
Drugchloro-m-cresol

RYR1 RYR2

1.90e-046822CID000012008
DrugMBED

RYR1 RYR2

1.90e-046822CID000129958
DrugAC1O528X

RYR1 RYR2

1.90e-046822CID006475857
Drugestradiol enanthate

CP SERPINA6

1.90e-046822CID000021070
DrugNSC114784

RYR1 RYR2

1.90e-046822CID000419425
DrugNSC93767

SCN3A SCN9A SCN10A

2.07e-0432823CID000005658
Drugbupropion

SCN3A SCN9A SCN10A HRH1

2.11e-0481824CID000000444
DrugNSC-270916

PTPN5 ADAMTS13 SERPINA6 F8

2.21e-0482824CID000002949
DrugTacrolimus

PTPN5 DPP4 ARV1 CP C4B ATP2A2 RYR1

2.23e-04339827ctd:D016559
Drug5-hydroxypropafenone

SCN3A SCN9A SCN10A

2.49e-0434823CID000107927
Drugforskolin from Coleus forskohlii

PTPN5 PTPA PDE8A PDE8B SCN3A SCN9A SCN10A HRH1 FGFR2 RYR1 RYR2 GABRA6

2.64e-0410138212CID000003413
DrugCoagulation Factor IX

LRP1 F8

2.66e-047822DB00100
DrugOrphenadrine

SCN10A HRH1

2.66e-047822DB01173
Drug[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate

RYR1 RYR2

2.66e-047822CID009547999
DrugAzumoleno

RYR1 RYR2

2.66e-047822CID000056259
DrugBr2BAPTA

RYR1 RYR2

2.66e-047822CID003081001
DrugCHAPS detergent

LRP1 AKAP3 SERPINA6 RYR1 RYR2

2.68e-04158825CID000107670
Drugendothall

DOCK5 PPP2R3A PTPA

2.95e-0436823CID000003225
Drugmag-fura-2

ATP2A2 RYR1 RYR2

3.20e-0437823CID000123839
DrugLeu-Glu

DPP4 SCN2A TNXB

3.20e-0437823CID000484686
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN9A SCN10A

3.02e-1110795DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN9A SCN10A

3.02e-1110795DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN9A SCN10A

9.44e-1112795DOID:0060170 (implicated_via_orthology)
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN2A SCN9A ADGRV1

5.93e-099794C3502809
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN9A

3.36e-0722794DOID:2030 (implicated_via_orthology)
DiseaseCongenital Pain Insensitivity

SCN9A SCN10A PRDM12

6.41e-077793C0002768
Diseaseepilepsy (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN9A SCN10A LRP1

5.16e-06163796DOID:1826 (implicated_via_orthology)
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN2A SCN9A

5.18e-0613793C0751122
DiseaseEarly Infantile Epileptic Encephalopathy 6

SCN1A SCN9A

7.08e-062792C4551549
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR1 RYR2

2.12e-053792DOID:3529 (implicated_via_orthology)
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR1 RYR2

2.12e-053792DOID:8545 (implicated_via_orthology)
DiseasePrimary Erythermalgia

SCN9A SCN10A

2.12e-053792C0014805
DiseasePAROXYSMAL EXTREME PAIN DISORDER

SCN9A SCN10A

2.12e-053792C1833661
Diseasepulmonary hypertension (biomarker_via_orthology)

ATP2A2 RYR1 RYR2 SMAD4

6.45e-0580794DOID:6432 (biomarker_via_orthology)
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

1.47e-047792C0149886
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

1.47e-047792C0751057
DiseaseHereditary Sensory Autonomic Neuropathy, Type 5

SCN9A SCN10A

1.47e-047792C0020075
DiseaseEarly Childhood Epilepsy, Myoclonic

SCN1A SCN9A

1.96e-048792C0393695
DiseaseIdiopathic Myoclonic Epilepsy

SCN1A SCN9A

1.96e-048792C0338478
DiseaseSymptomatic Myoclonic Epilepsy

SCN1A SCN9A

1.96e-048792C0338479
DiseaseBenign Infantile Myoclonic Epilepsy

SCN1A SCN9A

1.96e-048792C0751120
DiseaseMyoclonic Encephalopathy

SCN1A SCN9A

1.96e-048792C0438414
DiseaseMyoclonic Absence Epilepsy

SCN1A SCN9A

1.96e-048792C0393703
DiseasePruritus

SCN9A HRH1

1.96e-048792C0033774
DiseaseFebrile Convulsions

SCN1A SCN2A

2.52e-049792C0009952
DiseaseMyoclonic Epilepsy

SCN1A SCN9A

2.52e-049792C0014550
Diseasepostburn hypertrophic scarring severity measurement

DSG1 ARAP2

3.14e-0410792EFO_0007747
DiseaseEpilepsy, Myoclonic, Infantile

SCN1A SCN9A

3.14e-0410792C0917800
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

PPP2R3A IGF2R DNAH10 CAPN3 APOA4

3.17e-04220795EFO_0004529, EFO_0008317
DiseaseDiabetic Cardiomyopathies

ATP2A2 RYR2

3.83e-0411792C0853897
DiseaseMyoclonic Astatic Epilepsy

SCN1A SCN9A

3.83e-0411792C0393702
DiseaseCongenital muscular dystrophy

FKTN RYR1

4.59e-0412792cv:C0699743
DiseaseSkin Abnormalities

FGFR2 CHUK

5.42e-0413792C0037268
DiseaseSchizophrenia

PTPN5 LRP1 HRH1 CP APOA4 FGFR2 ATP2A2 TNXB GABRA6

5.84e-04883799C0036341
DiseaseMental Depression

DPP4 FGFR2 SERPINA6 ATP2A2 GABRA6

6.10e-04254795C0011570
DiseaseAutosomal recessive limb-girdle muscular dystrophy

FKTN CAPN3

6.31e-0414792cv:C2931907
Diseasevery low density lipoprotein cholesterol measurement

PPP2R3A IGF2R DNAH10 CAPN3 APOA4

6.77e-04260795EFO_0008317
DiseaseMMR-related febrile seizures

SCN1A SCN2A

7.27e-0415792EFO_0006519
DiseaseNeuralgia, Supraorbital

SCN9A SCN10A

8.29e-0416792C0038870
DiseaseNeuralgia

SCN9A SCN10A

8.29e-0416792C0027796
DiseaseNeuralgia, Atypical

SCN9A SCN10A

8.29e-0416792C0234247
DiseaseNeuralgia, Stump

SCN9A SCN10A

8.29e-0416792C0234249
DiseaseNeuralgia, Iliohypogastric Nerve

SCN9A SCN10A

8.29e-0416792C0423712
DiseaseNeuralgia, Perineal

SCN9A SCN10A

8.29e-0416792C0423711
DiseaseParoxysmal Nerve Pain

SCN9A SCN10A

8.29e-0416792C0751373
DiseaseNerve Pain

SCN9A SCN10A

8.29e-0416792C0751372
DiseaseNeuralgia, Ilioinguinal

SCN9A SCN10A

8.29e-0416792C0751371
DiseaseNeuralgia, Vidian

SCN9A SCN10A

8.29e-0416792C0042656
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

SCN1A SCN2A

8.29e-0416792C0393706
Diseaseheart disease (biomarker_via_orthology)

CP ATP2A2

9.38e-0417792DOID:114 (biomarker_via_orthology)
Diseasemuscular dystrophy (is_implicated_in)

FKTN CAPN3

9.38e-0417792DOID:9884 (is_implicated_in)
DiseaseMultiple congenital anomalies

FGFR2 CHUK

9.38e-0417792C0000772
DiseaseLimb Deformities, Congenital

FGFR2 CHUK

9.38e-0417792C0206762
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A

1.05e-0318792HP_0002373
DiseaseDepressive disorder

DPP4 FGFR2 SERPINA6 ATP2A2 GABRA6

1.09e-03289795C0011581
DiseaseIntrahepatic Cholangiocarcinoma

FGFR2 SMAD4

1.88e-0324792C0345905
DiseaseExtrahepatic Cholangiocarcinoma

FGFR2 SMAD4

1.88e-0324792C3805278
DiseaseNeurodevelopmental Disorders

SCN1A SCN2A SRCAP

2.02e-0393793C1535926
DiseaseLimb-girdle muscular dystrophy

FKTN CAPN3

2.21e-0326792cv:C0686353
DiseaseCholangiocarcinoma

FGFR2 SMAD4

2.21e-0326792C0206698

Protein segments in the cluster

PeptideGeneStartEntry
FDEWNSLAVYVSMDN

ATG4A

161

Q8WYN0
FTDFDKYMTISDEWD

EIF3B

266

P55884
EMEEAELTSWYFVSS

C4B

351

P0C0L5
AQVSIMTYDEFEYCW

APOBEC3B

331

Q9UH17
TFGEIMVYWELSSEF

ADGRV1

4676

Q8WXG9
MVYWELSSEFDITED

ADGRV1

4681

Q8WXG9
TEWMTSIFIAQHEYD

ARAP2

1526

Q8WZ64
GEFWMTFEDVCRYFT

CAPN5

321

O15484
VLYWESESSQAEMEF

ADAMTS13

1376

Q76LX8
FFEAVSTQMEKWYER

ANKRD6

671

Q9Y2G4
EVEDFIGVDSMYENW

ITPRIP

186

Q8IWB1
FTYSEWMEEKIEDDF

PTPN5

191

P54829
WADLNAMNVYETTEF

TIPARP

311

Q7Z3E1
WSQYFESMEDVEVEN

PPME1

46

Q9Y570
EVSADQVATVMWDYF

APOA4

21

P06727
EFVVMFSVVDENFSW

CP

216

P00450
EEFNTWVNNMYVFFV

RSPH10B

756

P0C881
QNWVFVTEGMDDFRY

FAM47C

46

Q5HY64
ETWYFMVNVTDAISS

FGFR2

116

P21802
DKFWNMALTDVDETY

LSM11

191

P83369
FANVFVSYMEEEQLW

KIAA0825

866

Q8IV33
IDQDEFWAFSYDEMA

LIPM

146

Q5VYY2
VQWEAVYMAIAFSVS

FNDC7

131

Q5VTL7
TVDYWSFGTMVFECI

CHUK

201

O15111
MDMFSVSVFEDFIYW

LRP1

2096

Q07954
FIDYFITDMFDAWDA

PDE8A

781

O60658
FIDYFITDMFDAWDA

PDE8B

836

O95263
QNWVFVTEGMDDFRY

FAM47B

46

Q8NA70
VGVDFQAMWYTDEDH

DPP4

726

P27487
EYTMDVFFRQTWTDE

GABRA6

76

Q16445
IFDETKSWYFTENME

F8

1901

P00451
MWEVFNEDGTVRYFI

PRDM12

136

Q9H4Q4
MSYADFVWFLISEED

PPP2R3A

956

Q06190
DEEFSANWMAVIFFI

DSG1

296

Q02413
DAQWETDDTAEYEMV

PTPRS

781

Q13332
EVWMDEFKNFFYIIS

GALNT1

371

Q10472
IMDDEEFAYCWENFV

APOBEC3F

146

Q8IUX4
VIWVYSTDTNFSDMF

ATP2A2

1026

P16615
DNEFATMWIERTTYT

DOCK5

1476

Q9H7D0
FFQSMEWDVGSDYAI

ARV1

251

Q9H2C2
IDTIDWNTFEFYMQI

GALNT4

256

Q8N4A0
NASDFDQWEMETVYS

CCP110

96

O43303
DVFFFYEETDHMWNG

FKTN

366

O75072
MDCFEVYSPEADQWT

KLHDC8A

46

Q8IYD2
WVTVALMESDFEFEY

FRY

2046

Q5TBA9
ETDFYDVTWFKVMTA

HRH1

181

P35367
VTEDGEFWMSYEDFI

CAPN3

391

P20807
YEGAFTWEFRDEMVN

DNAH10

3361

Q8IVF4
EWTVMDVVEYFTEAG

SAMD1

461

Q6SPF0
WYFEVMVDEVTPFLT

RYR1

661

P21817
WYFEFETVTAGDMRV

RYR2

1101

Q92736
YESEVLAMNFQDWAT

SERPINA6

151

P08185
RMVWDSQASEHFFEY

CHID1

331

Q9BWS9
EMEEAELTSWYFVSS

C4A

351

P0C0L4
YFAMVAENESEQESW

IRS4

176

O14654
MFISAVEDCEYTFAW

IGF2R

1486

P11717
RLSTFYEDWSFVMDE

SNX29

141

Q8TEQ0
YFCEVMFTAAWEFVV

TMEM229B

21

Q8NBD8
EYWCSIAYFEMDVQV

SMAD4

321

Q13485
QSDIWKMENEFYEFA

HS2ST1

306

Q7LGA3
MFYEVWEKFDPDATQ

SCN9A

1781

Q15858
SEDDFEMFYEVWEKF

SCN3A

1786

Q9NY46
DMEQITESSNYEWFD

IMPG2

746

Q9BZV3
TESSNYEWFDSEVSM

IMPG2

751

Q9BZV3
DTVVFYDSDWNPTMD

SRCAP

2131

Q6ZRS2
FFYFESVKEQEWSMA

OCRL

286

Q01968
SEDDFEMFYEVWEKF

SCN1A

1801

P35498
FMYDSDSWAEDLIVS

AKAP3

516

O75969
FQFVVVEEQYEESFW

CLRN2

176

A0PK11
DWFFIMQDDTYVQAP

CHPF2

176

Q9P2E5
VSQWYELVVFTASME

CTDNEP1

121

O95476
SYFITWDEDMFDEET

ATP11A

376

P98196
FEDVAVFFTQEEWDY

ZNF189

16

O75820
MAFEDVAVYFSQEEW

ZNF324

1

O75467
VMFSDVSIDFSQEEW

ZNF383

6

Q8NA42
FEYRVSEMWNEVHEE

PTPA

66

Q15257
LSEDDFDMFYETWEK

SCN10A

1736

Q9Y5Y9
TFEDMAVYFSEEEWQ

ZNF75CP

206

Q92670
WMVTEGEFDSFEIQY

TNXB

1901

P22105
SEDDFEMFYEVWEKF

SCN2A

1791

Q99250
VMENEVDAFWCFASY

TBC1D15

466

Q8TC07
VMFSDVSVDFSQEEW

ZNF566

6

Q969W8
GWSFCEYFMVQEELA

TRAPPC10

216

P48553
LSFEDVAMYFTREEW

ZNF789

11

Q5FWF6
MTFEDVAVYFSQEEW

ZNF324B

1

Q6AW86
TFEDVSMDFSQEEWE

ZNF554

46

Q86TJ5