Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Atresia of the external auditory canal	FRAS1 GMNN CDC45 ORC1 GLI3	2.18e-05	58	31	5	HP:0000413
HumanPheno	Microtia, third degree	GMNN CDC45 ORC1	3.26e-05	11	31	3	HP:0011267
HumanPheno	Mandibular aplasia	GMNN CDC45 ORC1	5.60e-05	13	31	3	HP:0009939
HumanPheno	Cutaneous finger syndactyly	FRAS1 KAT6A CDC45 ORC1 GLI3	6.26e-05	72	31	5	HP:0010554
HumanPheno	Submucous cleft hard palate	GMNN CDC45 ORC1 DGCR8 GDF11	6.26e-05	72	31	5	HP:0000176
HumanPheno	Submucous cleft of soft and hard palate	GMNN CDC45 ORC1 DGCR8 GDF11	6.26e-05	72	31	5	HP:0410031
HumanPheno	Anotia	GMNN CDC45 ORC1	7.10e-05	14	31	3	HP:0009892
HumanPheno	Submucous cleft lip/palate	GMNN CDC45 ORC1 DGCR8 GDF11	7.14e-05	74	31	5	HP:0000208
HumanPheno	Cleft hard palate	GMNN CDC45 ORC1 DGCR8 GDF11	8.65e-05	77	31	5	HP:0410005
HumanPheno	Submucous cleft palate	GMNN CDC45 ORC1 DGCR8 GDF11	1.24e-04	83	31	5	HP:5201016
HumanPheno	Breast aplasia	GMNN CDC45 ORC1	1.31e-04	17	31	3	HP:0100783
HumanPheno	Elbow dislocation	GMNN CDC45 ORC1 AEBP1 GLI3	1.31e-04	84	31	5	HP:0003042
HumanPheno	Aplastic clavicle	GMNN CDC45 ORC1	1.85e-04	19	31	3	HP:0006660
HumanPheno	Upper extremity joint dislocation	GMNN CDC45 ORC1 AEBP1 GLI3	2.47e-04	96	31	5	HP:0030310
HumanPheno	Abnormal auditory canal morphology	FRAS1 GMNN CDC45 ORC1 GLI3	2.72e-04	98	31	5	HP:0000372
HumanPheno	Patellar aplasia	GMNN CDC45 ORC1	2.91e-04	22	31	3	HP:0006443
HumanPheno	Cutaneous syndactyly	FRAS1 KAT6A CDC45 ORC1 GLI3	3.43e-04	103	31	5	HP:0012725
Domain	DUF2476	PRR23A PRR23B	1.62e-04	4	98	2	PF10630
Domain	PRR23	PRR23A PRR23B	1.62e-04	4	98	2	IPR018903
Domain	FYVE	ZFYVE16 RBSN FGD5	4.64e-04	29	98	3	PF01363
Domain	FYVE	ZFYVE16 RBSN FGD5	4.64e-04	29	98	3	SM00064
Domain	Znf_FYVE-rel	ZFYVE16 RBSN FGD5	7.45e-04	34	98	3	IPR017455
Domain	Calx_beta	FRAS1 ADGRV1	7.48e-04	8	98	2	SM00237
Domain	Calx_beta	FRAS1 ADGRV1	9.58e-04	9	98	2	IPR003644
Domain	Calx-beta	FRAS1 ADGRV1	9.58e-04	9	98	2	PF03160
Domain	Znf_FYVE	ZFYVE16 RBSN FGD5	1.03e-03	38	98	3	IPR000306
Domain	Znf_FYVE_PHD	ZFYVE16 KAT6A RBSN ANKIB1 FGD5	1.06e-03	147	98	5	IPR011011
Domain	ZF_FYVE	ZFYVE16 RBSN FGD5	1.20e-03	40	98	3	PS50178
Domain	Ras_G-nucl-exch_fac_CS	RALGDS SOS2	2.38e-03	14	98	2	IPR019804
Domain	Cadherin_CS	CDHR1 PCDHB6 PCDH18 CDH8	2.60e-03	109	98	4	IPR020894
Domain	CADHERIN_1	CDHR1 PCDHB6 PCDH18 CDH8	2.97e-03	113	98	4	PS00232
Domain	Cadherin	CDHR1 PCDHB6 PCDH18 CDH8	2.97e-03	113	98	4	PF00028
Domain	CADHERIN_2	CDHR1 PCDHB6 PCDH18 CDH8	3.06e-03	114	98	4	PS50268
Domain	-	CDHR1 PCDHB6 PCDH18 CDH8	3.06e-03	114	98	4	2.60.40.60
Domain	CA	CDHR1 PCDHB6 PCDH18 CDH8	3.16e-03	115	98	4	SM00112
Domain	Cadherin-like	CDHR1 PCDHB6 PCDH18 CDH8	3.26e-03	116	98	4	IPR015919
Domain	Cadherin	CDHR1 PCDHB6 PCDH18 CDH8	3.46e-03	118	98	4	IPR002126
Domain	GOLGA2L5	GOLGA6C GOLGA6B	3.95e-03	18	98	2	PF15070
Domain	Golgin_A	GOLGA6C GOLGA6B	3.95e-03	18	98	2	IPR024858
Domain	RasGEFN	RALGDS SOS2	4.87e-03	20	98	2	SM00229
Domain	RasGEF_N	RALGDS SOS2	5.36e-03	21	98	2	PF00618
Domain	Ras-like_Gua-exchang_fac_N	RALGDS SOS2	5.88e-03	22	98	2	IPR000651
Domain	RASGEF_NTER	RALGDS SOS2	5.88e-03	22	98	2	PS50212
Domain	Quino_amine_DH_bsu	WDR36 NBAS	5.88e-03	22	98	2	IPR011044
Pathway	REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX	MCM7 GMNN CDC45 ORC1	1.34e-05	32	65	4	MM15368
Pathway	REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX	MCM7 GMNN CDC45 ORC1	1.52e-05	33	65	4	M9694
Pathway	WP_DNA_REPLICATION	MCM7 GMNN CDC45 ORC1	4.04e-05	42	65	4	M39335
Pathway	KEGG_MEDICUS_REFERENCE_DNA_REPLICATION_LICENSING	MCM7 CDC45 ORC1	1.77e-04	24	65	3	M47857
Pathway	KEGG_MEDICUS_REFERENCE_PRE_IC_FORMATION	MCM7 CDC45 ORC1	2.53e-04	27	65	3	M47858
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	ZFYVE16 ARID4A GON4L UBN2 CEP350 RLF RNPS1 EPC1 ZNF638 CHD6 CABIN1 CPSF7	4.42e-07	645	102	12	25281560
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KIAA1549 GON4L MEAK7 GPR107 HERC4 PCDH18	5.55e-07	101	102	6	10997877
Pubmed	RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly.	CEP350 IFT88 CEP19	8.50e-07	7	102	3	28428259
Pubmed	Self-assembling protein microarrays.	MCM7 GMNN CDC45 ORC1	1.80e-06	30	102	4	15232106
Pubmed	A role for primary cilia in aortic valve development and disease.	NFATC1 IFT88 GLI3	2.90e-06	10	102	3	28556366
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FRAS1 LRCH2 ZFYVE16 GON4L FHIP1B AKAP9 CHD6 CAMSAP2 BAIAP3	3.31e-06	407	102	9	12693553
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RALGDS KIAA1549 ADGRV1 PREPL GPR107 NUP205 SUPT6H ANKIB1 ESPL1 HERC4	3.71e-06	529	102	10	14621295
Pubmed	A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.	GOLGA6C GOLGA6B IFT88 GLI3	4.27e-06	37	102	4	21725307
Pubmed	The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.	CEP350 IFT88 CEP19	5.29e-06	12	102	3	28625565
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	WDR36 GON4L FHIP1B NUP205 RLF GLI3 COPS4 DCTN4	6.24e-06	331	102	8	19490893
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PIK3R3 KAT6A FRYL ADGRV1 UBN2 RLF NFATC1 SUPT6H ANKAR ANKIB1 ZNF638 SLC9A7 PRKCE CHD6 BAIAP3 SOS2	6.90e-06	1489	102	16	28611215
Pubmed	Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin.	NFATC1 IFT88 GLI3	8.71e-06	14	102	3	32151560
Pubmed	Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures.	MCM7 CDC45 ORC1	2.29e-05	19	102	3	15226314
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PDE2A POLR2C PREPL CEP350 ZNF334 IFT88 COPS4 CCDC15 CHD6 DGCR8 CABIN1 TRIM37 CNOT3 SOS2	2.36e-05	1285	102	14	35914814
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	WDR36 ARID4A POLR2C DDX42 NOL10 UBN2 ORC1 RNPS1 SUPT6H EPC1 ZNF638 CHD6 CABIN1 CPSF7	2.55e-05	1294	102	14	30804502
Pubmed	Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha.	MCM7 CDC45	2.55e-05	3	102	2	10518787
Pubmed	Differential diagnosis of reactive mesothelial cells and malignant mesothelioma cells using the cell proliferation markers minichromosome maintenance protein 7, geminin, topoisomerase II alpha and Ki-67.	MCM7 GMNN	2.55e-05	3	102	2	23860238
Pubmed	CEP19 cooperates with FOP and CEP350 to drive early steps in the ciliogenesis programme.	CEP350 CEP19	2.55e-05	3	102	2	28659385
Pubmed	Molecular Pathway of Microtubule Organization at the Golgi Apparatus.	AKAP9 CAMSAP2	2.55e-05	3	102	2	27666745
Pubmed	Primary cilia defects causing mitral valve prolapse.	NFATC1 IFT88	2.55e-05	3	102	2	31118289
Pubmed	Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP.	AKAP9 PRKCE	2.55e-05	3	102	2	10945988
Pubmed	Intraflagellar transport molecules in ciliary and nonciliary cells of the retina.	GOLGA6C GOLGA6B IFT88	2.69e-05	20	102	3	20368623
Pubmed	Development of the post-natal growth plate requires intraflagellar transport proteins.	GOLGA6C GOLGA6B IFT88	2.69e-05	20	102	3	17359961
Pubmed	Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.	MCM7 CDC45 ORC1	2.69e-05	20	102	3	12614612
Pubmed	DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system.	MCM7 CDC45 ORC1	3.62e-05	22	102	3	15707391
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ABCA3 WDR36 MCM7 MEAK7 RNPS1 ANKIB1 ZNF638	3.98e-05	313	102	7	38270169
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	UBXN6 KIAA1549 CBARP MEAK7 GPR107 SLC7A2 SLC15A1 PHACTR4 PCDH18	4.69e-05	569	102	9	30639242
Pubmed	Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.	IFT88 GLI3	5.09e-05	4	102	2	19701205
Pubmed	Dual and opposing roles of primary cilia in medulloblastoma development.	IFT88 GLI3	5.09e-05	4	102	2	19701203
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	POLR2C MCM7 UBN2 TBC1D8 NFATC1 SUPT6H TRIM37 CNOT3 CPSF7	6.03e-05	588	102	9	38580884
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	CEP350 AKAP9 CCDC15 DCTN4 CEP19	7.31e-05	146	102	5	21399614
Pubmed	22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development.	CDC45 GLI3 DGCR8	8.47e-05	29	102	3	23077214
Pubmed	Nuclear organization of DNA replication initiation proteins in mammalian cells.	MCM7 ORC1	8.47e-05	5	102	2	11779870
Pubmed	Variants in the GH-IGF axis confer susceptibility to lung cancer.	CAMKK1 AKAP9	8.47e-05	5	102	2	16741161
Pubmed	Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma.	IFT88 GLI3	8.47e-05	5	102	2	24927541
Pubmed	Molecular architecture of the human GINS complex.	MCM7 CDC45	8.47e-05	5	102	2	17557111
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	VIL1 FRAS1 ADGRV1 AKAP9 ESPL1	8.84e-05	152	102	5	34299191
Pubmed	Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- mice.	GOLGA6C GOLGA6B IFT88	1.04e-04	31	102	3	17765678
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	FRAS1 WDR36 PIK3R3 DDX42 KIAA1549 CBARP PREPL TBC1D8 NBAS AKAP9 SUPT6H PHACTR4 COPS4 ESPL1	1.13e-04	1487	102	14	33957083
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PDE2A LRCH2 ASIC1 GOLGA6C GOLGA6B UBN2 PREPL AKAP9 PRKCE CABIN1 CAMSAP2	1.25e-04	963	102	11	28671696
Pubmed	Atypical E2F repressors and activators coordinate placental development.	ESX1 ESPL1 ZNF367	1.25e-04	33	102	3	22516201
Pubmed	Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.	IFT88 GLI3	1.27e-04	6	102	2	16254602
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	ARID4A PREPL GPR107 NUP205 CDC45 RLF NBAS RBSN MTF1 SLC7A6OS GLI3 EPC1 CPSF7	1.37e-04	1327	102	13	32694731
Pubmed	Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.	MCM7 CDC45 ORC1	1.37e-04	34	102	3	12791985
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	DDX42 AEBP1 RNPS1 NKAPD1 DCTN4 DDX39A	1.47e-04	269	102	6	29511261
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	WDR36 POLR2C MCM7 NOL10 NUP205 CDC45 RLF ORC1 RNPS1 ANKIB1 ZNF638 DCTN4 DDX39A	1.66e-04	1353	102	13	29467282
Pubmed	A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus.	IFT88 GLI3	1.77e-04	7	102	2	21653639
Pubmed	Mutations in the Neuroblastoma Amplified Sequence gene in a family affected by Acrofrontofacionasal Dysostosis type 1.	TNMD NBAS	1.77e-04	7	102	2	29929043
Pubmed	Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.	PDE2A CDHR1 MCM7 CDC45	1.81e-04	95	102	4	21440680
Pubmed	The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism.	MCM7 CDC45	2.36e-04	8	102	2	16912045
Pubmed	Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.	MCM7 CDC45	2.36e-04	8	102	2	19805216
Pubmed	Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium.	CDC45 DGCR8	2.36e-04	8	102	2	27184122
Pubmed	Biochemical characterization of the Ras-related GTPases Rit and Rin.	RALGDS RLF	2.36e-04	8	102	2	10545207
Pubmed	A WD-repeat protein stabilizes ORC binding to chromatin.	GMNN ORC1	2.36e-04	8	102	2	20932478
Pubmed	ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.	ARID4A KAT6A EPC1	2.59e-04	42	102	3	16387653
Pubmed	International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants.	CAMKK1 AKAP9	3.03e-04	9	102	2	20106900
Pubmed	Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.	IFT88 GLI3	3.03e-04	9	102	2	27802276
Pubmed	The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.	MCM7 CDC45	3.03e-04	9	102	2	25049228
Pubmed	L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability.	MCM7 CDC45	3.03e-04	9	102	2	21149733
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	WDR36 LRCH2 POLR2C MCM7 NUP205 SUPT6H ESPL1	3.25e-04	440	102	7	34244565
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	DDX42 FRYL UBN2 NKAPD1 ZNF638 ESPL1 DDX39A BAIAP3 HERC4 PCDH18 TRIM37	3.44e-04	1084	102	11	11544199
Pubmed	A piggyBac insertion disrupts Foxl2 expression that mimics BPES syndrome in mice.	PRR23A PRR23B	3.77e-04	10	102	2	24565867
Pubmed	Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase.	MCM7 CDC45	3.77e-04	10	102	2	35920641
Pubmed	Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.	GMNN ORC1	3.77e-04	10	102	2	11125146
Pubmed	Ependymal cilia beating induces an actin network to protect centrioles against shear stress.	AKAP9 IFT88	3.77e-04	10	102	2	29891944
Pubmed	Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication.	MCM7 CDC45	3.77e-04	10	102	2	16902406
Pubmed	Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis.	WDR36 POLR2C MCM7 DDX39A	4.01e-04	117	102	4	34662580
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FRAS1 PDE2A PCNX3 KAT6A FRYL FHIP1B ORC1 NFATC1 CABIN1 ESPL1 ALOX5	4.04e-04	1105	102	11	35748872
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	KAT6A PREPL CEP350 RNPS1 CHD6 CAMSAP2 TRIM37 CPSF7	4.33e-04	608	102	8	16713569
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ARID4A KAT6A UBN2 RLF RNPS1 NKAPD1 CHD6 CABIN1	4.33e-04	608	102	8	36089195
Pubmed	Primary cilia regulate Shh activity in the control of molar tooth number.	IFT88 GLI3	4.60e-04	11	102	2	19211681
Pubmed	De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.	POLR2C SUPT6H	4.60e-04	11	102	2	31045206
Pubmed	Distinct Activities of Gli1 and Gli2 in the Absence of Ift88 and the Primary Cilia.	IFT88 GLI3	4.60e-04	11	102	2	30791390
Pubmed	ROS/NF-κB Signaling Pathway-Mediated Transcriptional Activation of TRIM37 Promotes HBV-Associated Hepatic Fibrosis.	ATP1B4 TRIM37	4.60e-04	11	102	2	32916597
Pubmed	Functional characterization of putative cilia genes by high-content analysis.	IFT88 GLI3	4.60e-04	11	102	2	21289087
Pubmed	Temporal Regulation of ESCO2 Degradation by the MCM Complex, the CUL4-DDB1-VPRBP Complex, and the Anaphase-Promoting Complex.	MCM7 CDC45	4.60e-04	11	102	2	30100344
Pubmed	The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking.	IFT88 GLI3	4.60e-04	11	102	2	22689656
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	WDR36 MCM7 CBARP CEP350 RBSN GLI3 PHACTR4 ZNF638 DGCR8	4.77e-04	777	102	9	35844135
Pubmed	IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.	IFT88 GLI3	5.51e-04	12	102	2	22595669
Pubmed	Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate.	IFT88 GLI3	5.51e-04	12	102	2	28069795
Pubmed	Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.	MCM7 CDC45	5.51e-04	12	102	2	22474384
Pubmed	TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression.	MCM7 SUPT6H	5.51e-04	12	102	2	30479348
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	DDX42 GMNN CEP350 ORC1 NBAS COPS4 CCDC15 DCTN4 ESPL1 DDX39A CNOT3	5.84e-04	1155	102	11	20360068
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	VIL1 DNAH3 GLI3 PHACTR4 ANKIB1	6.35e-04	233	102	5	37704626
Pubmed	NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction.	CHD6 TRIM37	6.50e-04	13	102	2	28416489
Pubmed	IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment.	IFT88 GLI3	6.50e-04	13	102	2	25446516
Pubmed	Globozoospermia and lack of acrosome formation in GM130-deficient mice.	GOLGA6C GOLGA6B	6.50e-04	13	102	2	28055014
Pubmed	Protein interaction and cellular localization of human CDC45.	MCM7 CDC45	6.50e-04	13	102	2	23364835
Pubmed	GM130 regulates pulmonary surfactant protein secretion in alveolar type II cells.	GOLGA6C GOLGA6B	6.50e-04	13	102	2	33740186
Pubmed	Loss of GM130 does not impair oocyte meiosis and embryo development in mice.	GOLGA6C GOLGA6B	6.50e-04	13	102	2	32873390
Pubmed	GM130, a cis-Golgi protein, regulates meiotic spindle assembly and asymmetric division in mouse oocyte.	GOLGA6C GOLGA6B	6.50e-04	13	102	2	21552007
Pubmed	GOLGA2 loss causes fibrosis with autophagy in the mouse lung and liver.	GOLGA6C GOLGA6B	6.50e-04	13	102	2	29128360
Pubmed	Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice.	GOLGA6C GOLGA6B	6.50e-04	13	102	2	28028212
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	WDR36 DDX42 MCM7 NOL10 NUP205 ORC1 SUPT6H ZNF638 DGCR8 CPSF7	6.64e-04	989	102	10	36424410
Pubmed	The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development.	GOLGA6C GOLGA6B AKAP9	7.07e-04	59	102	3	26371508
Pubmed	GM130 and p115 play a key role in the organisation of the early secretory pathway during skeletal muscle differentiation.	GOLGA6C GOLGA6B	7.57e-04	14	102	2	30630895
Pubmed	Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors.	IFT88 GLI3	7.57e-04	14	102	2	15930098
Pubmed	Cdk1 protects against oxygen-glucose deprivation and reperfusion-induced Golgi fragmentation and apoptosis through mediating GM130 phosphorylation.	GOLGA6C GOLGA6B	7.57e-04	14	102	2	37831422
Pubmed	Interactions of MCP1 with components of the replication machinery in mammalian cells.	MCM7 CDC45	7.57e-04	14	102	2	21383955
Pubmed	Complex interactions between genes controlling trafficking in primary cilia.	IFT88 GLI3	7.57e-04	14	102	2	21552265
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	ZFYVE16 RBSN FGD5	1.46e-04	31	60	3	81
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	ZFYVE16 ARID4A KAT6A DDX42 FRYL CEP350 RLF NBAS AKAP9 ZNF638 CAMSAP2 HERC4 TRIM37 SOS2	5.85e-06	856	102	14	M4500
Coexpression	GSE16385_UNTREATED_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN	GMNN AKAP9 ZNF334 IFT88 ZNF638 CHD6 CEP19	1.36e-05	200	102	7	M7913
CoexpressionAtlas	dev gonad_e11.5_M_PrimGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_1000	WDR36 MCM7 GMNN NUP205 CDC45 DGCR8 ESPL1 DDX39A TRIM37	3.96e-06	258	101	9	gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_k2_1000
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#2_top-relative-expression-ranked_1000	WDR36 GMNN NUP205 CDC45 ORC1 DGCR8 ESPL1 TRIM37	4.04e-05	266	101	8	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k2_1000
ToppCell	3'_v3-blood-Lymphocytic_NK-Cycling_NK\|blood / Manually curated celltypes from each tissue	MCM7 GMNN CDC45 ORC1 ESPL1 DDX39A ZNF367	3.25e-07	194	102	7	bf9734abaad603ade2a6a6940918aaf1e1c4e2cd
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|343B / Donor, Lineage, Cell class and subclass (all cells)	MCM7 GMNN RLF ORC1 CCDC15 ZNF367	2.57e-06	169	102	6	02fa66a91b8bd2bf971aec4f5ec58318b5bfdf14
ToppCell	10x5'-blood-Lymphocytic_NK-Cycling_NK\|blood / Manually curated celltypes from each tissue	MCM7 GMNN CDC45 ORC1 CCDC15 ZNF367	3.58e-06	179	102	6	c93711273055a999335ba8d0f6500e4549f46cec
ToppCell	LPS-IL1RA-Epithelial_alveolar-Mes-Like-AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 PCDHB6 GMNN SLC7A2 P3H2	4.38e-06	105	102	5	8d5528ae2bdba17e2474a7ca07fc8596d1b04647
ToppCell	367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	MCM7 CDC45 SHD ORC1 ESPL1 ZNF367	4.74e-06	188	102	6	f5102e8d95506c25c675094b86162a6a50087b64
ToppCell	PBMC-Mild-cDC_12\|Mild / Compartment, Disease Groups and Clusters	MCM7 GMNN CDC45 ORC1 ZNF334 ZNF367	4.89e-06	189	102	6	946c95d2ecc36b241f58e8c4ad6455fe47c762fa
ToppCell	PBMC-Severe-cDC_12\|Severe / Compartment, Disease Groups and Clusters	MCM7 GMNN NUP205 CDC45 ORC1 ZNF367	5.04e-06	190	102	6	84ee185939bdefb10705b621a70da27701eadcee
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MCM7 GMNN CDC45 ORC1 CCDC15 ZNF367	5.19e-06	191	102	6	50854384fdaa0efa2e3227659d544ed09ac102f2
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic-lymphocyte-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	MCM7 GMNN CDC45 ORC1 ESPL1 DDX39A	5.19e-06	191	102	6	56b45259dfc38bd5ea43b0e3adf47e7e2c043a5d
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-Undetermined\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	MCM7 GMNN CDC45 ORC1 DDX39A ZNF367	5.35e-06	192	102	6	3856c4d611224cd6c2558631147cd5333bc0ccb7
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	5.68e-06	194	102	6	f39a471293ecc5c5967b00e772b8f48ebc9affbe
ToppCell	(1)_T_cells_Dividing\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	5.68e-06	194	102	6	8f313071933451780309d2174ed27d8cdc734343
ToppCell	Control-Lymphoid_T/NK-T/NK_proliferative\|Control / Disease group, lineage and cell class	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	5.68e-06	194	102	6	9bbb124001fba7450f4639f47f9b720a483e7242
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	5.68e-06	194	102	6	a75ecd0b0a928d4646602f7d16a645f6b3df3af5
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	5.68e-06	194	102	6	17744fd6645cf5a447a01a83f07e8d305c2bcd9c
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	5.68e-06	194	102	6	e14f66f7584909621b776292fbd52808273fd2ee
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MCM7 GMNN CDC45 ORC1 CCDC15 ZNF367	5.85e-06	195	102	6	cec7df321f372d05c94f97d6bb18891a5cc3dec3
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	MCM7 GMNN CDC45 ORC1 CCDC15 ZNF367	5.85e-06	195	102	6	b65463a804fed2d9a3be9e528ca8b9c98469bc86
ToppCell	(1)_T_cells-(1)_T_cells_Dividing\|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	5.85e-06	195	102	6	cf00a0b4f341f0487d5b37810abe2952fdd3f6f2
ToppCell	BAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.02e-06	196	102	6	6d80e23f6a1725a3f5ea7263233c55c2ea56f977
ToppCell	BAL-Control-Myeloid-Myeloid\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.02e-06	196	102	6	bf1d3fae8c01bb3d17c2dafad92b94937c663acd
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MCM7 GMNN CDC45 ORC1 CCDC15 ZNF367	6.02e-06	196	102	6	df366d76ea55f49e349d622effa57c1535df8400
ToppCell	BAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.02e-06	196	102	6	3dd7ed1dfac8d90c8a44f0ae00128bb46d9ef496
ToppCell	BAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.02e-06	196	102	6	4f649e3bfd21f21682678828673843a7d51c4ff2
ToppCell	BAL-Control-Myeloid-Myeloid\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.02e-06	196	102	6	799c290fb3dfacb666dd0dc3c43ec8a86b697ec7
ToppCell	BAL-Control-Myeloid-Myeloid-proliferating_Myeloid_cells\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.02e-06	196	102	6	0c003a767c3b58605099dab64b9df0d8e5d8bc4b
ToppCell	Healthy-T/NK_proliferative\|Healthy / disease group, cell group and cell class	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.02e-06	196	102	6	91e44aabb2e85dcc77ddae6f7e000118d45d1de6
ToppCell	Control-T/NK_proliferative\|Control / Disease condition and Cell class	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.02e-06	196	102	6	7b7bc25aef49bfd64f79303a92d527bf8188f7a6
ToppCell	Control-Myeloid-proliferating_Myeloid_cells\|Control / Disease group,lineage and cell class （2021.01.30）	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.20e-06	197	102	6	ddbe3fe078766bb55f0d7ca1aeb8f9e4aa696d8e
ToppCell	normal_Lymph_Node-T/NK_cells-Undetermined\|T/NK_cells / Location, Cell class and cell subclass	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.38e-06	198	102	6	47d572b9db2843aeb2079f33a852babf67270be4
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MCM7 GMNN CDC45 ORC1 CCDC15 ESPL1	6.38e-06	198	102	6	281fc2536cdc4c717b30de156e563c0e4baba99d
ToppCell	(0)_NK_Dividing\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.38e-06	198	102	6	5ebb4965b723302152b42bfaf48bb77a57dd02c5
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.57e-06	199	102	6	11c3d9fe811a4619347f47d2b0e94066e3085625
ToppCell	mild_COVID-19-T/NK_proliferative\|World / disease group, cell group and cell class (v2)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.57e-06	199	102	6	d44cc74d7171d96add61dae821daf774b17d4c69
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.57e-06	199	102	6	36c80907b2ec1cbcd1b4e841e6c02a4792591d74
ToppCell	COVID-19-COVID-19_Mild-Myeloid-immature_Neutrophil\|COVID-19_Mild / Disease, condition lineage and cell class	DNAH3 MCM7 ORC1 ESPL1 CAMSAP2 ZNF367	6.57e-06	199	102	6	e222b90caf45904d8f763574e7b6aac13333df92
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.57e-06	199	102	6	bf4c31902ae8358215245a2e11b5a2fe4ca1bc8c
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4/8-lo-Cycling_T\|lymph-node_spleen / Manually curated celltypes from each tissue	MCM7 GMNN CDC45 ORC1 ESPL1 DDX39A	6.57e-06	199	102	6	28fc342d2d178ce33203a78eb9eedae54fa9c916
ToppCell	COVID-19_Mild-Lymphoid_T/NK-T/NK_proliferative\|COVID-19_Mild / Disease group, lineage and cell class	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.57e-06	199	102	6	ddea0e5c1cb6a096ab8e09a8c3c37c1bff381d9c
ToppCell	Biopsy_Control_(H.)-Epithelial-Proliferating_Epithelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.57e-06	199	102	6	4fcf5bec207e4384fd73c5e8801a7e414e3ee7b0
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.57e-06	199	102	6	7beb0e07a27fea94674f24eb61c381b0de38ed3e
ToppCell	normal_Lung-T/NK_cells-Undetermined\|T/NK_cells / Location, Cell class and cell subclass	MCM7 GMNN CDC45 ESPL1 DDX39A ZNF367	6.57e-06	199	102	6	4142d5b1b20212508f95841fdac4efb7655616cb
ToppCell	COVID-19_Mild-T/NK_proliferative\|COVID-19_Mild / Disease condition and Cell class	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.57e-06	199	102	6	9f9a88d2b099646c1e1a7ee3f8d39cb1a2498ad7
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Radial_glial-RGCs_3\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	MCM7 GMNN CDC45 ORC1 GLI3 ZNF367	6.57e-06	199	102	6	79d87e2b0adeff2d33c3b699afe7211fddc4f285
ToppCell	mild_COVID-19-T/NK_proliferative\|mild_COVID-19 / disease group, cell group and cell class (v2)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.57e-06	199	102	6	df2fcaf01b1b48632f84e7355ef21d20853f0664
ToppCell	Mild-T/NK_proliferative\|Mild / Disease group and Cell class	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.57e-06	199	102	6	64a5c91243ee999ea21ffddd450d3e5fdbf6470b
ToppCell	distal-Hematologic-Proliferating_Macrophage\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.76e-06	200	102	6	3835a8a9739b8cd5bf19c40765ef76907ac1ad38
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-T/NK_proliferative\|COVID-19_Mild / Disease, condition lineage and cell class	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.76e-06	200	102	6	6126a3bbafe2110fba0c1c4493035df4e8193d22
ToppCell	Control-Control-Lymphocyte-T/NK-T/NK_proliferative\|Control / Disease, condition lineage and cell class	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.76e-06	200	102	6	6cf63dd57f6bc0c42e7182322dd24ff9afbe9186
ToppCell	severe-T/NK_proliferative\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MCM7 GMNN CDC45 ORC1 DDX39A ZNF367	6.76e-06	200	102	6	9d6e7e2d6cfa8c96bbb5c187815df96ecaa5475c
ToppCell	healthy_donor-Lymphocytic-Proliferative_Lymphocyte\|healthy_donor / Disease condition, Lineage, Cell class and subclass	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.76e-06	200	102	6	e4eb915c29909cf8535a3603c68976545c05e54b
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-T/NK_proliferative\|ICU-NoSEP / Disease, condition lineage and cell class	MCM7 GMNN CDC45 ORC1 DDX39A ZNF367	6.76e-06	200	102	6	f70cc9198339eab7fbc68f5d9b75dfb28c9afc89
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-T/NK_proliferative\|Int-URO / Disease, condition lineage and cell class	CDHR1 MCM7 GMNN CDC45 ESPL1 ZNF367	6.76e-06	200	102	6	99acc1ea01288efdd5b166aa20d66735f2bbe543
ToppCell	healthy_donor-Lymphocytic-Proliferative_Lymphocyte-\|healthy_donor / Disease condition, Lineage, Cell class and subclass	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.76e-06	200	102	6	415e7556b5ac45688e2c6c30a52bd40e0eb27c7d
ToppCell	LAM-Myeloid-pMacrophage\|LAM / Condition, Lineage and Cell class	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.76e-06	200	102	6	7e233d037165c9d3607604aaaf0f368e266567d3
ToppCell	Biopsy_Other_PF-Immune-Proliferating_Macrophages\|Biopsy_Other_PF / Sample group, Lineage and Cell type	MCM7 GMNN CDC45 ORC1 ESPL1 ZNF367	6.76e-06	200	102	6	61473e8613f39a92002d5b631e6bd563735566e4
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-T_NK_proliferative\|ICU-NoSEP / Disease, Lineage and Cell Type	MCM7 GMNN CDC45 ORC1 DDX39A ZNF367	6.76e-06	200	102	6	d86119766b9c4f1570cd8045313345f9be46d431
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MCM7 GMNN ESPL1 BAIAP3 TRIM37	3.27e-05	159	102	5	e9c51e611ebd427bbe51e3e036c14122c36ea372
ToppCell	normal_Lymph_Node-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	PCNX3 NUP205 SHD HERC4 ALOX5	4.13e-05	167	102	5	820472887f43b42ae7e44513ca3d5465fb4f71a7
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CDC45 ORC1 CCDC15 ESPL1 ZNF367	4.13e-05	167	102	5	bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCell	10x5'-blood-Myeloid_Dendritic-pDC\|blood / Manually curated celltypes from each tissue	SHD ZNF334 AEBP1 P3H2 SLC9A7	4.50e-05	170	102	5	59cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCell	367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	MCM7 CDC45 SHD ORC1 ZNF367	4.76e-05	172	102	5	8d20eda599abf1e9e3e3b90f314acddee6a465a4
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MCM7 GMNN CDC45 ORC1 CCDC15	4.76e-05	172	102	5	7c238a7375341d4647ba7274d93fddfb6fae7ce4
ToppCell	10x5'-bone_marrow-Lymphocytic_NK-Cycling_NK\|bone_marrow / Manually curated celltypes from each tissue	MCM7 GMNN CDC45 ESPL1 ZNF367	4.89e-05	173	102	5	8a9dd85f718564c07cf3120ad648daeb60c94fc5
ToppCell	droplet-Lung-nan-3m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCM7 ORC1 SLC7A2 ALOX5 ZNF367	5.60e-05	178	102	5	de6cd81e6d58e7687386df163471bf1901b9c0aa
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MCM7 GMNN ORC1 CCDC15 ZNF367	5.60e-05	178	102	5	c7e890cd02206c516cf1d7692ea7abc8ce746482
ToppCell	droplet-Lung-nan-18m-Myeloid-Proliferating_Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOXRED1 MCM7 GMNN CDC45 ORC1	6.22e-05	182	102	5	11494a66d986297b837332ee9d382b71b9f22591
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MCM7 GMNN CDC45 ORC1 ESPL1	6.38e-05	183	102	5	6c1d7ce60e67bf1df364a4e177c351e7313eb41f
ToppCell	droplet-Marrow-BM-1m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A MCM7 GMNN CDC45 ALOX5	7.07e-05	187	102	5	6be99f71532b7d679d1287ea1bb08245d9538db7
ToppCell	droplet-Marrow-nan-21m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE2A MCM7 GMNN CDC45 ALOX5	7.25e-05	188	102	5	1526e271411e381eae7a342003002276f83f47a3
ToppCell	renal_cortex_nuclei-Adult_normal_reference\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 KIAA1549 TBC1D8 P3H2 ZNF638	7.43e-05	189	102	5	a48df46274d51e84ffb40264646de7346104efb9
ToppCell	Int-URO-Lymphocyte-T_NK-T_NK_proliferative\|Int-URO / Disease, Lineage and Cell Type	CDHR1 MCM7 GMNN CDC45 ZNF367	7.62e-05	190	102	5	005967c540418b85311308072a07c684f4296aef
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c12-MKI67-TYROBP\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MCM7 GMNN CDC45 ORC1 ZNF367	7.62e-05	190	102	5	c3c65d1f24e0ebdbb9adb617bed299a668f423f5
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MCM7 CDC45 ORC1 ESPL1 ZNF367	7.81e-05	191	102	5	b85a0978dc1e8af4f49423f56dcfd52efce09ed1
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	ZFYVE16 FRYL ADGRV1 CEP350 AKAP9	8.20e-05	193	102	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	normal_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_DZ\|normal_Lymph_Node / Location, Cell class and cell subclass	MCM7 GMNN CDC45 ORC1 DDX39A	8.20e-05	193	102	5	5ce93860bc60ce6ecfed3a3d985f84e28781eec1
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MCM7 CDC45 ORC1 ESPL1 ZNF367	8.20e-05	193	102	5	e45ce9cf8421512b57f157c24b64793b47b4ba4b
ToppCell	P03-Endothelial-proliferative_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MCM7 GMNN CDC45 DDX39A ZNF367	8.40e-05	194	102	5	22bcfb0f3f73608feb22c0847ab4d34f87aeede0
ToppCell	P03-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MCM7 GMNN CDC45 DDX39A ZNF367	8.40e-05	194	102	5	5e56ce9b9fe0721be3a9e6efe1422599bb867721
ToppCell	wk_20-22-Hematologic_Lymphocytic-B-Pro-B\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MCM7 GMNN CDC45 ORC1 ZNF367	8.40e-05	194	102	5	3590ff471f74a361ee5bf02a58e3104cd3bf7d00
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MCM7 GMNN CDC45 ORC1 ZNF367	8.40e-05	194	102	5	4c1d13d8cb6fb424655c67755ee6dbaf59d6b418
ToppCell	Influenza_Severe-T/NK_proliferative\|World / Disease group and Cell class	MCM7 GMNN CDC45 ORC1 ESPL1	8.61e-05	195	102	5	6f079c2d7d08110a5e1822ea861b8037eb3f62c9
ToppCell	Healthy/Control-T/NK_proliferative\|Healthy/Control / Disease group and Cell class	MCM7 GMNN CDC45 ORC1 ESPL1	8.61e-05	195	102	5	957458fdc39723f4a31bd7fd3ce32891aa3fd462
ToppCell	mild-Lymphocytic-Prol._cells\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MCM7 GMNN CDC45 ORC1 ESPL1	8.61e-05	195	102	5	9a8cc9097a349fd0a53ccf2723ee8bb1418d6aca
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	GMNN CDC45 ORC1 ESPL1 ZNF367	8.61e-05	195	102	5	1a5e814e12fe37287dbfc58189e1958e2c76b5da
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	MCM7 GMNN CDC45 ORC1 CCDC15	8.61e-05	195	102	5	56d8734d020b3da08a5aa9e67999706a9e023a99
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_1\|343B / Donor, Lineage, Cell class and subclass (all cells)	MCM7 GMNN CDC45 ORC1 ESPL1	8.61e-05	195	102	5	47a01b8a92eebeb34ac7f70bf1ab4613a326e24f
ToppCell	ILEUM-non-inflamed-(1)_Highly_activated_T_cells\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	MCM7 GMNN CDC45 ORC1 DDX39A	8.82e-05	196	102	5	6a415a2574bd84bd825a2bd6c8e3632a433ff7cf
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MCM7 CDC45 CCDC15 ESPL1 ZNF367	8.82e-05	196	102	5	1d2e0b328eb822db7521b5f5724d4bd17c0bad5f
ToppCell	cycling_basal_cell\|World / shred by cell class for nasal brushing	MCM7 GMNN CDC45 ORC1 ZNF367	8.82e-05	196	102	5	aa7bac70a2fe4a3cb28d89fa1a87c68c2ead1349
ToppCell	mild-Lymphocytic-Prol._cells\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MCM7 GMNN CDC45 ORC1 ESPL1	8.82e-05	196	102	5	b1d9866d5dfaefdb8bedaf01a750d97987acb3d1
ToppCell	severe_COVID-19-T/NK_proliferative\|World / disease group, cell group and cell class (v2)	MCM7 GMNN CDC45 ORC1 ZNF367	9.03e-05	197	102	5	189d97a6c2ff8803db8cc05e205c9d88dac3911f
ToppCell	ICU-SEP-Lymphocyte-T_NK-T_NK_proliferative\|ICU-SEP / Disease, Lineage and Cell Type	MCM7 GMNN CDC45 ORC1 ZNF367	9.03e-05	197	102	5	908e91fa16134b61943aea5e8fc0d6fbac8a8c6e
ToppCell	Mild_COVID-19-T/NK-proliferating_T/NK\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	MCM7 CDC45 ORC1 ESPL1 ZNF367	9.03e-05	197	102	5	5fd52fba2cb6fa67377f873da2ff6ce9c83b0591
ToppCell	Healthy/Control-T/NK_proliferative\|World / Disease group and Cell class	MCM7 GMNN CDC45 ORC1 ESPL1	9.03e-05	197	102	5	4a4d3083938783d6f5b87da02f10e501917da0b4
ToppCell	COVID-19_Severe-T/NK_proliferative\|COVID-19_Severe / Disease condition and Cell class	MCM7 GMNN CDC45 ORC1 ZNF367	9.03e-05	197	102	5	718a84e9a8248080f2d964e7c6a3ba183ece9592
ToppCell	wk_20-22-Hematologic_Lymphocytic-B-Large_pre-B\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MCM7 GMNN CDC45 ORC1 ZNF367	9.03e-05	197	102	5	cebf47d66f425c84d3fea962e11f5bf4bfe2e60f
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MCM7 CDC45 ORC1 ESPL1 ZNF367	9.03e-05	197	102	5	d7a9296092153cf66426911fecd810f0c1ef978e
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MCM7 CDC45 ORC1 ESPL1 ZNF367	9.03e-05	197	102	5	dcff23240bb7cb652d7426b29355aa74442ef6fc
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	MCM7 CDC45 ORC1 ESPL1 ZNF367	9.03e-05	197	102	5	434a5686a103bb766e0d80038413f0e12ea3981a
Computational	Genes in the cancer module 397.	GON4L GMNN NUP205 CDC45 ORC1 CABIN1	3.68e-05	121	56	6	MODULE_397
Computational	Genes in the cancer module 57.	MCM7 CDC45 ORC1 ESPL1	1.98e-04	56	56	4	MODULE_57
Computational	Nucleotide metabolism.	GMNN NUP205 CDC45 ORC1	3.33e-04	64	56	4	MODULE_337
Disease	EAR, PATELLA, SHORT STATURE SYNDROME	GMNN CDC45 ORC1	1.12e-06	7	95	3	C1868684
Disease	phospholipase B-like 1 measurement	COPS4 ZNF367	1.02e-04	5	95	2	EFO_0802865
Disease	chromosome 22q11.2 deletion syndrome, distal (implicated_via_orthology)	CDC45 DGCR8	9.10e-04	14	95	2	DOID:0060413 (implicated_via_orthology)
Disease	Chronic myeloproliferative disorder	GMNN ORC1	1.69e-03	19	95	2	C1292778
Disease	Colorectal Carcinoma	RALGDS DNAH3 ABCA3 AKAP9 NFATC1 GLI3 PRKCE CAMSAP2	1.95e-03	702	95	8	C0009402
Disease	Seckel syndrome	GMNN ORC1	2.27e-03	22	95	2	C0265202
Disease	QRS duration, response to sulfonylurea	SLC15A1 ZNF638	2.48e-03	23	95	2	EFO_0005055, EFO_0007922
Disease	Dwarfism	GMNN ORC1	2.93e-03	25	95	2	C0013336
Disease	response to peginterferon alfa-2a	NBAS ZNF367	2.93e-03	25	95	2	EFO_0010103
Disease	FEV change measurement, response to zileuton	SLC7A2 PRKCE	2.93e-03	25	95	2	EFO_0005921, EFO_0007676
Disease	mean corpuscular hemoglobin concentration	VIL1 ARID4A PIK3R3 GON4L MEAK7 COPS4 ZNF638 PRKCE DDX39A ZNF367	2.96e-03	1105	95	10	EFO_0004528

Protein segments in the cluster

Peptide	Gene	Start	Entry
QEEGDAPQEDFIQYI	CBARP	346	Q8N350
LQELENFFDESQYPD	ESX1	151	Q8N693
FSLDAEQPDYDLDSE	EPC1	106	Q9H2F5
EQPDYDLDSEDEVFV	EPC1	111	Q9H2F5
ENEDPELQDYRYEVQ	AKAP9	1236	Q99996
IDEDAEEPNNLVDYS	CDHR1	596	Q96JP9
ELDPEERDNFLQQLY	ARID4A	306	P29374
FVYDIEVEFPQDDQL	CEP19	136	Q96LK0
PDQVDDEEALLSYLQ	BAIAP3	156	O94812
EQPGFEENLLEESQY	B4GALNT3	421	Q6L9W6
PTLDYNDQIEREDYE	AEBP1	231	Q8IUX7
VENDLLDYDEEEEPQ	DDX39A	6	O00148
YNLTVLDDEVPENDE	ADGRV1	216	Q8WXG9
ILDDDEPEGQEFFYV	ADGRV1	5316	Q8WXG9
EKALRNEYFEAEPED	ABCA3	511	Q99758
DPEAEEIEAEYAALD	ANKIB1	206	Q9P2G1
DEEALNFPYEDDFDN	DGCR8	231	Q8WYQ5
NFPYEDDFDNDVDAL	DGCR8	236	Q8WYQ5
LRDENNEEDAYPDNV	SLC7A2	611	P52569
LDDPDEANQNYLADE	ATP1B4	21	Q9UN42
DPDFEENEFLYDDLD	CNOT3	216	O75175
ENEFLYDDLDLEDIP	CNOT3	221	O75175
AIEQYNALDEYPAED	RBM48	71	Q5RL73
YNPFEEEDEEEEAVA	RBSN	661	Q9H1K0
DLIDIYADEEFNQDP	CPSF7	6	Q8N684
DNPYLQLSQEEEDLE	GPR107	551	Q5VW38
YEPQLEDFVDQFVEL	NUP205	776	Q92621
EIPENYEEDDFDNVL	PCDH18	1091	Q9HCL0
EGDDNPVQLIYFVED	KIAA1549	1231	Q9HCM3
TKDPDFNEIYDEDVN	ANKAR	206	Q7Z5J8
AEEPGELEDNYLEYL	FHIP1B	541	Q8N612
NDEDAPTIEFEEAAY	FRAS1	3031	Q86XX4
LNDEDFLPDDVVQYL	GLI3	1086	P10071
NARFLPDEEDVDFIN	GLIPR1L2	41	Q4G1C9
PDEEDVDFINEYVNL	GLIPR1L2	46	Q4G1C9
EVLDDPAEDNLYLVF	CAMKK1	216	Q8N5S9
PFEADNEDDLFESIL	PRKCE	606	Q02156
FEDEEEDSSNVDLPY	DDX42	76	Q86XP3
EEPAALYDAIAANEE	PCNX3	1661	Q9H6A9
NSLDFLDEEYEVPDL	PDE2A	911	O00408
LEDDDPVQAEAYINR	COPS4	156	Q9BT78
VLEEEALDDALANPY	FGD5	416	Q6ZNL6
IIAAFQPVAYDDEEE	FRYL	2671	O94915
QQLLDYPEDDIEETF	HERC4	846	Q5GLZ8
EPEELDQLYLDDVNE	NFATC1	916	O95644
FDEVINADDLDVAYQ	LRGUK	576	Q96M69
FLPEEQAEIDQLFDA	MEAK7	16	Q6P9B6
NPDFQVDEESEEFRL	NOL10	491	Q9BSC4
HPDDEDVLDNVDYYE	P3H2	336	Q8IVL5
DDFYEVSLDNNVEPA	GOLGA6B	651	A6NDN3
VEPNLQDESEFLYAA	NBAS	811	A2RRP1
PIQYRDEEDEDESYQ	PHACTR4	521	Q8IZ21
PAQFQAALDEYEELN	MCM7	691	P33993
QFVLIEGDDDENPYV	ORC1	51	Q13415
EEEEDENELFPREYF	KAT6A	1071	Q92794
DADENYFINEEDENL	PIK3R3	336	Q92569
QDDDLEVPAYEDIFR	CDC45	121	O75419
PGNLEEFEVNDLNYE	ESPL1	706	Q14674
NDYNPIYDIEELEND	IFT88	21	Q13099
DPEEEDDSFNNYEVQ	CABIN1	426	Q9Y6J0
DYADLPYQIEDIFDN	DNAH3	756	Q8TD57
DEDLFNPDYVEVDRI	CHD6	366	Q8TD26
GDALQPEDFLEEDEY	GDF11	121	O95390
ADDDDDPEYNFLEDL	GON4L	551	Q3T8J9
IPENFDDYVDINEDE	CEP350	2566	Q5VT06
DDFYEVSLDNNVEPA	GOLGA6C	651	A6NDK9
HNLEEEEPEDYELLQ	RALGDS	836	Q12967
IDDEYAPAVFQLDQL	GLMP	256	Q8WWB7
VLDVNDNAPEFASEY	CDH8	486	P55286
DAAAEYDELAEPQDF	DCTN4	371	Q9UJW0
YDELAEPQDFQDDPD	DCTN4	376	Q9UJW0
TYINPAEIEAQFDED	SLC15A1	671	P46059
EELQEPFYTDQYDQE	CAMSAP2	51	Q08AD1
QEVYDFVDPNTEDVA	LRCH2	401	Q5VUJ6
DNVPEFAQELYEAQV	PCDHB6	236	Q9Y5E3
DLESLQFEYGVPEED	NOXRED1	6	Q6NXP6
EPLDNFESLDNQEFD	GMNN	161	O75496
EAEAHIDYEDNFPDD	SUSD5	201	O60279
GDLDLDLVYEDEVNQ	TRIM37	516	O94972
AYVEFENPDEAEKAL	RNPS1	206	Q15287
LIADYSPDDIFNADE	TIGD6	166	Q17RP2
AQKNLDFEDPYEDAE	SHD	36	Q96IW2
FEDLAEEQAFDPYET	SOS2	281	Q07890
EEQAFDPYETLSQDI	SOS2	286	Q07890
AQEEAYEEDADPEFP	PRR23A	151	A6NEV1
EEDPELQDFVNDVYV	ALOX5	501	P09917
YFEENKLVDEDFPED	RIMOC1	76	A6NDU8
PDNNIIYFEAEEDEL	MTF1	6	Q14872
PEIAAQEEAYEEDAD	PRR23B	146	Q6ZRT6
DNDPNDYVEQDDILI	POLR2C	136	P19387
QDILPEAQDYFLEAQ	CCDC15	326	Q0P6D6
ADPALDFLVEKDQEY	ASIC1	346	P78348
LYPEEFETDSDQQDI	NKAPD1	116	Q6ZUT1
LVNDDQEPEDIYDDE	SLC7A6OS	226	Q96CW6
APYRPDQQVEEDDDF	SUPT6H	756	Q7KZ85
EELPINDYTENGIEF	TNMD	241	Q9H2S6
IPDFNQDDLEEDDVF	VIL1	636	P09327
QDQEDPEEFYVLSET	UBXN6	231	Q9BZV1
ETDPFIDNSEAYDEL	UBN2	211	Q6ZU65
VEEFSNQNYPDIDDA	ZNF334	71	Q9HCZ1
ELYLQPDQKFDEENA	RLF	431	Q13129
FDQEDPDSYLEEEDN	SPEM2	176	Q0P670
EDPEENDLYQAIATV	TBC1D8	1006	O95759
EADNDNYEVLFNLEE	PREPL	136	Q4J6C6
QQDPLEYLQSDEEDD	ZNF367	301	Q7RTV3
YDNQEPLREEDSDFI	SLC9A7	641	Q96T83
NEDLEELSRYPDEQL	ZNF638	151	Q14966
ENDPEANIDTIYDRF	ZNF638	996	Q14966
LDDFEQNPDEQDYLQ	ZFYVE16	16	Q7Z3T8
DELIEYDSPEQLNEQ	WDR36	736	Q8NI36