Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 TSPOAP1 RIMBP3C RIMBP3B	9.66e-10	5	76	4	GO:0030156
GeneOntologyMolecularFunction	sialic acid binding	SIGLEC10 SIGLEC14 SIGLEC5 SIGLEC11	2.31e-06	25	76	4	GO:0033691
GeneOntologyMolecularFunction	11-cis retinal binding	ABCA4 RHO	2.97e-04	7	76	2	GO:0005502
GeneOntologyBiologicalProcess	neuromuscular synaptic transmission	RIMBP3 TSPOAP1 RIMBP3C RIMBP3B	9.66e-06	36	77	4	GO:0007274
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of pain	TRPV1 ASIC3	4.12e-05	3	77	2	GO:0050968
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B	1.53e-04	28	78	3	GO:0002177
GeneOntologyCellularComponent	tertiary granule	ATAD3B ASAH1 FOLR3 SIGLEC14 SIGLEC5	3.72e-04	164	78	5	GO:0070820
MousePheno	abnormal vitamin A level	ABCA4 SIK3 RHO	4.20e-05	15	65	3	MP:0011232
MousePheno	detached acrosome	RIMBP3 RIMBP3C AGBL5 RIMBP3B	5.03e-05	44	65	4	MP:0009231
MousePheno	abnormal manchette morphology	RIMBP3 RIMBP3C AGBL5 RIMBP3B	5.50e-05	45	65	4	MP:0009376
MousePheno	ectopic manchette	RIMBP3 RIMBP3C RIMBP3B	8.82e-05	19	65	3	MP:0009377
MousePheno	detached sperm flagellum	RIMBP3 RIMBP3C RIMBP3B	1.20e-04	21	65	3	MP:0008893
MousePheno	abnormal eosinophil differentiation	SIGLEC14 SIGLEC5	1.27e-04	4	65	2	MP:0002443
MousePheno	abnormal vitamin level	ABCA4 SIK3 SLC23A1 RHO	1.82e-04	61	65	4	MP:0005400
Domain	-	RIMBP3 EPHB4 TSPOAP1 ICAM5 SIGLEC10 SIGLEC14 SIGLEC5 ROBO2 RIMBP3C SIGLEC11 DCC RIMBP3B DSCAML1 PLXNB1	3.95e-07	663	76	14	2.60.40.10
Domain	Ig-like_fold	RIMBP3 EPHB4 TSPOAP1 ICAM5 SIGLEC10 SIGLEC14 SIGLEC5 ROBO2 RIMBP3C SIGLEC11 DCC RIMBP3B DSCAML1 PLXNB1	8.38e-07	706	76	14	IPR013783
Domain	FN3	RIMBP3 EPHB4 TSPOAP1 ROBO2 RIMBP3C DCC RIMBP3B DSCAML1	1.46e-06	199	76	8	PS50853
Domain	FN3_dom	RIMBP3 EPHB4 TSPOAP1 ROBO2 RIMBP3C DCC RIMBP3B DSCAML1	2.11e-06	209	76	8	IPR003961
Domain	IGc2	ICAM5 SIGLEC10 SIGLEC14 SIGLEC5 ROBO2 SIGLEC11 DCC DSCAML1	5.03e-06	235	76	8	SM00408
Domain	Ig_sub2	ICAM5 SIGLEC10 SIGLEC14 SIGLEC5 ROBO2 SIGLEC11 DCC DSCAML1	5.03e-06	235	76	8	IPR003598
Domain	FN3	EPHB4 TSPOAP1 ROBO2 RIMBP3C DCC RIMBP3B DSCAML1	1.03e-05	185	76	7	SM00060
Domain	Ig_I-set	ICAM5 SIGLEC10 SIGLEC14 ROBO2 SIGLEC11 DCC DSCAML1	1.22e-05	190	76	7	IPR013098
Domain	I-set	ICAM5 SIGLEC10 SIGLEC14 ROBO2 SIGLEC11 DCC DSCAML1	1.22e-05	190	76	7	PF07679
Domain	UBA	SIK2 SIK1 TNRC6C SIK3	3.04e-05	44	76	4	IPR015940
Domain	UBA	SIK2 SIK1 TNRC6C SIK3	3.95e-05	47	76	4	PS50030
Domain	Ago_hook	TNRC6B TNRC6C	4.89e-05	3	76	2	PF10427
Domain	Ser/Thr_kinase_SIK1/2	SIK2 SIK1	4.89e-05	3	76	2	IPR017090
Domain	TNRC6_PABC-bd	TNRC6B TNRC6C	4.89e-05	3	76	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6B TNRC6C	4.89e-05	3	76	2	IPR019486
Domain	TNRC6-PABC_bdg	TNRC6B TNRC6C	4.89e-05	3	76	2	PF16608
Domain	Ig/MHC_CS	SIGLEC10 SIGLEC14 SIGLEC5 SIGLEC11	9.09e-05	58	76	4	IPR003006
Domain	IG_MHC	SIGLEC10 SIGLEC14 SIGLEC5 SIGLEC11	1.04e-04	60	76	4	PS00290
Domain	ig	ICAM5 SIGLEC10 SIGLEC14 SIGLEC5 SIGLEC11 DSCAML1	1.24e-04	190	76	6	PF00047
Domain	Immunoglobulin	ICAM5 SIGLEC10 SIGLEC14 SIGLEC5 SIGLEC11 DSCAML1	1.24e-04	190	76	6	IPR013151
Domain	Ig_V-set	SIGLEC10 SIGLEC14 SIGLEC5 ROBO2 SIGLEC11 DSCAML1	1.60e-04	199	76	6	IPR013106
Domain	SH3_9	RIMBP3 TSPOAP1 RIMBP3C RIMBP3B	2.87e-04	78	76	4	PF14604
Domain	IG	ICAM5 SIGLEC10 SIGLEC14 SIGLEC5 ROBO2 SIGLEC11 DCC DSCAML1	3.08e-04	421	76	8	SM00409
Domain	Ig_sub	ICAM5 SIGLEC10 SIGLEC14 SIGLEC5 ROBO2 SIGLEC11 DCC DSCAML1	3.08e-04	421	76	8	IPR003599
Domain	SH3_2	RIMBP3 TSPOAP1 RIMBP3C RIMBP3B	4.18e-04	86	76	4	IPR011511
Domain	SH3_2	RIMBP3 TSPOAP1 RIMBP3C RIMBP3B	4.18e-04	86	76	4	PF07653
Domain	fn3	EPHB4 TSPOAP1 ROBO2 DCC DSCAML1	5.19e-04	162	76	5	PF00041
Domain	IG_LIKE	ICAM5 SIGLEC10 SIGLEC14 SIGLEC5 ROBO2 SIGLEC11 DCC DSCAML1	8.49e-04	491	76	8	PS50835
Domain	Ig-like_dom	ICAM5 SIGLEC10 SIGLEC14 SIGLEC5 ROBO2 SIGLEC11 DCC DSCAML1	9.91e-04	503	76	8	IPR007110
Domain	CUB	LRP12 CSMD2 PCOLCE	1.04e-03	49	76	3	PF00431
Domain	CUB	LRP12 CSMD2 PCOLCE	1.11e-03	50	76	3	SM00042
Domain	-	LRP12 CSMD2 PCOLCE	1.24e-03	52	76	3	2.60.120.290
Domain	Sushi	SUSD2 C2 CSMD2	1.24e-03	52	76	3	PF00084
Domain	CUB	LRP12 CSMD2 PCOLCE	1.31e-03	53	76	3	PS01180
Domain	CCP	SUSD2 C2 CSMD2	1.38e-03	54	76	3	SM00032
Domain	SUSHI	SUSD2 C2 CSMD2	1.54e-03	56	76	3	PS50923
Domain	Sushi_SCR_CCP_dom	SUSD2 C2 CSMD2	1.62e-03	57	76	3	IPR000436
Domain	CUB_dom	LRP12 CSMD2 PCOLCE	1.62e-03	57	76	3	IPR000859
Domain	-	PREB TULP4 WDR88 HERC1 WDR77 PLXNB1	2.36e-03	333	76	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	PREB TULP4 WDR88 HERC1 WDR77 PLXNB1	2.43e-03	335	76	6	IPR015943
Domain	Ig_2	ICAM5 SIGLEC10 SIGLEC14	3.28e-03	73	76	3	PF13895
Domain	Peptidase_M14	AGBL5 AGBL3	3.91e-03	23	76	2	PF00246
Domain	Peptidase_M14	AGBL5 AGBL3	3.91e-03	23	76	2	IPR000834
Domain	WD40	PREB TULP4 WDR88 HERC1 WDR77	4.09e-03	259	76	5	PF00400
Domain	Ephrin_rec_like	EPHB4 PCSK5	4.61e-03	25	76	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHB4 PCSK5	4.61e-03	25	76	2	IPR011641
Domain	WD40	PREB TULP4 WDR88 HERC1 WDR77	4.73e-03	268	76	5	SM00320
Domain	WD40_repeat	PREB TULP4 WDR88 HERC1 WDR77	5.03e-03	272	76	5	IPR001680
Domain	WD_REPEATS_1	PREB TULP4 WDR88 HERC1 WDR77	5.51e-03	278	76	5	PS00678
Domain	WD_REPEATS_2	PREB TULP4 WDR88 HERC1 WDR77	5.59e-03	279	76	5	PS50082
Domain	WD_REPEATS_REGION	PREB TULP4 WDR88 HERC1 WDR77	5.59e-03	279	76	5	PS50294
Domain	UBA	SIK1 TNRC6C	6.60e-03	30	76	2	SM00165
Domain	V-set	SIGLEC10 SIGLEC14 SIGLEC5 SIGLEC11	6.74e-03	184	76	4	PF07686
Domain	WD40_repeat_dom	PREB TULP4 WDR88 HERC1 WDR77	7.24e-03	297	76	5	IPR017986
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 TSPOAP1 RIMBP3C RIMBP3B	1.17e-10	5	78	4	17855024
Pubmed	Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G).	SIGLEC10 SIGLEC14 SIGLEC5 SIGLEC11	3.50e-10	6	78	4	14559209
Pubmed	Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages.	SIK2 SIK1 SIK3	1.09e-08	3	78	3	27920213
Pubmed	Salt-inducible kinase 3 deficiency exacerbates lipopolysaccharide-induced endotoxin shock accompanied by increased levels of pro-inflammatory molecules in mice.	SIK2 SIK1 SIK3	1.09e-08	3	78	3	25619259
Pubmed	Salt-inducible Kinases Are Critical Determinants of Female Fertility.	SIK2 SIK1 SIK3	1.09e-08	3	78	3	32343771
Pubmed	CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.	SIGLEC10 SIGLEC14 SIGLEC5 SIGLEC11	1.65e-08	13	78	4	35921817
Pubmed	Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.	SIK2 SIK1 SIK3	4.33e-08	4	78	3	29941929
Pubmed	Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity.	SIK2 SIK1 SIK3	4.33e-08	4	78	3	18348280
Pubmed	The LKB1-SIK Pathway Controls Dendrite Self-Avoidance in Purkinje Cells.	SIK2 SIK1 ROBO2	4.33e-08	4	78	3	30208308
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	4.33e-08	4	78	3	19091768
Pubmed	Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.	SIK2 SIK1 SIK3	1.08e-07	5	78	3	23033494
Pubmed	A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis.	SIK2 SIK1 SIK3	1.08e-07	5	78	3	36862513
Pubmed	Salt inducible kinases 2 and 3 are required for thymic T cell development.	SIK2 SIK1 SIK3	1.08e-07	5	78	3	34732767
Pubmed	14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).	SIK2 SIK1 SIK3	2.16e-07	6	78	3	29211348
Pubmed	Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells.	SIK2 SIK1 SIK3	2.16e-07	6	78	3	33600797
Pubmed	Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.	SIK2 SIK1 SIK3	2.16e-07	6	78	3	34160349
Pubmed	SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype.	SIK2 SIK1 SIK3	2.16e-07	6	78	3	26590148
Pubmed	Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.	SIGLEC10 SIGLEC14 SIGLEC5 SIGLEC11	2.40e-07	24	78	4	15331780
Pubmed	The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.	SIK2 SIK1 SIK3	3.77e-07	7	78	3	25088745
Pubmed	Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling.	SIK2 SIK1 SIK3	6.03e-07	8	78	3	31430259
Pubmed	Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.	SIGLEC10 SIGLEC5 SIGLEC11	1.29e-06	10	78	3	25320078
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	3.88e-06	14	78	3	17662146
Pubmed	LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.	SIK2 SIK1 SIK3	4.84e-06	15	78	3	14976552
Pubmed	Acid-sensing ion channel 3, but not capsaicin receptor TRPV1, plays a protective role in isoproterenol-induced myocardial ischemia in mice.	TRPV1 ASIC3	4.97e-06	2	78	2	21127383
Pubmed	Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.	SIGLEC14 SIGLEC5	4.97e-06	2	78	2	24799499
Pubmed	High-Throughput Implementation of the NanoBRET Target Engagement Intracellular Kinase Assay to Reveal Differential Compound Engagement by SIK2/3 Isoforms.	SIK2 SIK3	4.97e-06	2	78	2	31849250
Pubmed	Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors.	TRPV1 ASIC3	4.97e-06	2	78	2	33655767
Pubmed	LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription.	SIK2 SIK1	4.97e-06	2	78	2	23577667
Pubmed	Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia.	TRPV1 ASIC3	4.97e-06	2	78	2	27896621
Pubmed	Differential effects of ASIC3 and TRPV1 deletion on gastroesophageal sensation in mice.	TRPV1 ASIC3	4.97e-06	2	78	2	17975130
Pubmed	TRPV1 Responses in the Cerebellum Lobules VI, VII, VIII Using Electroacupuncture Treatment for Chronic Pain and Depression Comorbidity in a Murine Model.	TRPV1 ASIC3	4.97e-06	2	78	2	34068557
Pubmed	Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake.	SIK2 SIK1	4.97e-06	2	78	2	33688765
Pubmed	Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.	SIK2 SIK1	4.97e-06	2	78	2	32457359
Pubmed	Salt-inducible kinase 2 and -3 are downregulated in adipose tissue from obese or insulin-resistant individuals: implications for insulin signalling and glucose uptake in human adipocytes.	SIK2 SIK3	4.97e-06	2	78	2	27807598
Pubmed	The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3.	TRPV1 ASIC3	4.97e-06	2	78	2	16306411
Pubmed	Short-term sensitization of colon mechanoreceptors is associated with long-term hypersensitivity to colon distention in the mouse.	TRPV1 ASIC3	4.97e-06	2	78	2	17553498
Pubmed	Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.	SIGLEC14 SIGLEC5	4.97e-06	2	78	2	26459514
Pubmed	Acid-induced CGRP release from the stomach does not depend on TRPV1 or ASIC3.	TRPV1 ASIC3	4.97e-06	2	78	2	20100279
Pubmed	Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses.	SIK2 SIK3	4.97e-06	2	78	2	31969556
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SIK2 TNRC6B TNRC6C SIK3 DSCAML1 ADCY6	1.19e-05	225	78	6	12168954
Pubmed	Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia.	TRPV1 ASIC3	1.49e-05	3	78	2	24957987
Pubmed	Acid-sensing ion channel 3 is required for agmatine-induced histamine-independent itch in mice.	TRPV1 ASIC3	1.49e-05	3	78	2	36937045
Pubmed	Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model.	SIGLEC14 SIGLEC5	1.49e-05	3	78	2	24698729
Pubmed	SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.	SIGLEC10 SIGLEC11	1.49e-05	3	78	2	24859880
Pubmed	Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells.	TRPV1 ASIC3	1.49e-05	3	78	2	28187208
Pubmed	Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.	SIGLEC14 SIGLEC5	1.49e-05	3	78	2	11579105
Pubmed	Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice.	GLP1R ADCY6	1.49e-05	3	78	2	22832924
Pubmed	Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.	SIGLEC14 SIGLEC5	1.49e-05	3	78	2	17012248
Pubmed	Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.	SIGLEC14 SIGLEC5	1.49e-05	3	78	2	31520477
Pubmed	Antiallergic effect of anti-Siglec-F through reduction of eosinophilic inflammation in murine allergic rhinitis.	SIGLEC14 SIGLEC5	1.49e-05	3	78	2	23710953
Pubmed	Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling.	SIGLEC14 SIGLEC5	1.49e-05	3	78	2	19783675
Pubmed	Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice.	SIGLEC14 SIGLEC5	1.49e-05	3	78	2	30577572
Pubmed	TDAG8, TRPV1, and ASIC3 involved in establishing hyperalgesic priming in experimental rheumatoid arthritis.	TRPV1 ASIC3	1.49e-05	3	78	2	28827659
Pubmed	Chromenone derivatives as novel pharmacological chaperones for retinitis pigmentosa-linked rod opsin mutants.	ABCA4 RHO	1.49e-05	3	78	2	35642742
Pubmed	A novel Siglec-F+ neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model.	SIGLEC14 SIGLEC5	1.49e-05	3	78	2	32247614
Pubmed	A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4.	ABCA4 IRF6	1.49e-05	3	78	2	20436469
Pubmed	Vitamin A aldehyde-taurine adducts function in photoreceptor cells.	ABCA4 RHO	1.49e-05	3	78	2	35809434
Pubmed	mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapy.	ABCA4 RHO	1.49e-05	3	78	2	37852949
Pubmed	Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm.	SIK2 SIK1	1.49e-05	3	78	2	15511237
Pubmed	An LKB1-SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation.	SIK1 SIK3	1.49e-05	3	78	2	31350327
Pubmed	The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC.	SIK1 SIK3	1.49e-05	3	78	2	31350328
Pubmed	The role of Siglec-G on B cells in autoimmune disease and leukemia.	SIGLEC10 SIGLEC11	1.49e-05	3	78	2	38042621
Pubmed	Acid-induced pain and its modulation in humans.	TRPV1 ASIC3	1.49e-05	3	78	2	15574747
Pubmed	The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells.	SIGLEC10 SIGLEC11	1.49e-05	3	78	2	24790146
Pubmed	Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.	TNRC6B TNRC6C	1.49e-05	3	78	2	34108231
Pubmed	Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population.	SIGLEC10 SIGLEC11	1.49e-05	3	78	2	17572677
Pubmed	Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.	SIGLEC10 SIGLEC11	1.49e-05	3	78	2	23836061
Pubmed	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.	TNRC6B TNRC6C	1.49e-05	3	78	2	16880270
Pubmed	Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration.	ABCA4 RHO	1.49e-05	3	78	2	22169101
Pubmed	Salt-Inducible Kinase 1 Terminates cAMP Signaling by an Evolutionarily Conserved Negative-Feedback Loop in β-Cells.	SIK2 SIK1	1.49e-05	3	78	2	25918234
Pubmed	Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.	TNRC6B TNRC6C	1.49e-05	3	78	2	31670606
Pubmed	Frontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls.	SIGLEC14 SIGLEC5	1.49e-05	3	78	2	32134149
Pubmed	Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.	SIGLEC14 SIGLEC5	1.49e-05	3	78	2	25497369
Pubmed	Siglec-F is a novel intestinal M cell marker.	SIGLEC14 SIGLEC5	1.49e-05	3	78	2	27524237
Pubmed	Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity.	SIGLEC14 SIGLEC5	2.97e-05	4	78	2	17562860
Pubmed	Siglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activation.	SIGLEC10 SIGLEC11	2.97e-05	4	78	2	17912374
Pubmed	Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.	SIGLEC14 SIGLEC5	2.97e-05	4	78	2	17272508
Pubmed	Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo.	SIGLEC10 SIGLEC11	2.97e-05	4	78	2	20038598
Pubmed	CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity.	SIGLEC10 SIGLEC11	2.97e-05	4	78	2	20200274
Pubmed	Siglec-G regulates B1 cell survival and selection.	SIGLEC10 SIGLEC11	2.97e-05	4	78	2	20729333
Pubmed	Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.	SIGLEC14 SIGLEC5	2.97e-05	4	78	2	33289969
Pubmed	IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils.	SIGLEC14 SIGLEC5	2.97e-05	4	78	2	33976385
Pubmed	Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade.	SIK2 SIK1	2.97e-05	4	78	2	16817901
Pubmed	Sialic Acid Ligand Binding of CD22 and Siglec-G Determines Distinct B Cell Functions but Is Dispensable for B Cell Tolerance Induction.	SIGLEC10 SIGLEC11	2.97e-05	4	78	2	30143587
Pubmed	Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors.	SIGLEC14 SIGLEC5	2.97e-05	4	78	2	19178537
Pubmed	Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.	SIK2 SIK1	2.97e-05	4	78	2	12624099
Pubmed	Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.	SIK2 SIK1	2.97e-05	4	78	2	30030465
Pubmed	Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice.	SIGLEC10 SIGLEC11	2.97e-05	4	78	2	24695850
Pubmed	Induction of Siglec-FhiCD101hi eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.	SIGLEC14 SIGLEC5	2.97e-05	4	78	2	37251384
Pubmed	Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye.	ABCA4 RHO	2.97e-05	4	78	2	24952647
Pubmed	Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.	TNRC6B TNRC6C	2.97e-05	4	78	2	21063388
Pubmed	Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells.	SIGLEC10 SIGLEC11	2.97e-05	4	78	2	25252961
Pubmed	Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.	SIGLEC10 SIGLEC11	2.97e-05	4	78	2	24600033
Pubmed	14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.	SIK2 SIK1 SIK3	4.22e-05	30	78	3	16306228
Pubmed	STK11 is required for the normal program of ciliated cell differentiation in airways.	SIK2 SIK1 SIK3	4.66e-05	31	78	3	31636950
Pubmed	Netrin1-DCC-Mediated Attraction Guides Post-Crossing Commissural Axons in the Hindbrain.	ROBO2 DCC	4.94e-05	5	78	2	26290247
Pubmed	Galanin receptor 3 - A new pharmacological target in retina degeneration.	ABCA4 RHO	4.94e-05	5	78	2	36693600
Pubmed	Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs.	SIGLEC14 SIGLEC5	4.94e-05	5	78	2	20395633
Pubmed	Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13.	SIGLEC14 SIGLEC5	4.94e-05	5	78	2	21040544
Pubmed	Involvement of ASIC3 and Substance P in Therapeutic Ultrasound-Mediated Analgesia in Mouse Models of Fibromyalgia.	TRPV1 ASIC3	4.94e-05	5	78	2	37054767
Interaction	SLURP1 interactions	EPHB4 PCSK5 ICAM5 HS6ST2 SIK3 DDX11	1.74e-05	144	76	6	int:SLURP1
Cytoband	22q11.21	RIMBP3 PI4KA RIMBP3C RIMBP3B	4.02e-05	111	78	4	22q11.21
Cytoband	Ensembl 112 genes in cytogenetic band chr22q11	RIMBP3 PI4KA SUSD2 RIMBP3C RIMBP3B	7.56e-04	419	78	5	chr22q11
Cytoband	7q22	EPHB4 PCOLCE	1.93e-03	38	78	2	7q22
Cytoband	Ensembl 112 genes in cytogenetic band chr8q22	LRP12 TP53INP1 CCNE2	2.99e-03	168	78	3	chr8q22
GeneFamily	CD molecules\|C2-set domain containing\|Sialic acid binding Ig like lectins	SIGLEC10 SIGLEC14 SIGLEC5 SIGLEC11	1.09e-06	28	51	4	745
GeneFamily	Fibronectin type III domain containing	EPHB4 TSPOAP1 ROBO2 DCC DSCAML1	8.62e-05	160	51	5	555
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SUSD2 C2 CSMD2	5.56e-04	57	51	3	1179
GeneFamily	WD repeat domain containing	PREB TULP4 WDR88 HERC1 WDR77	8.39e-04	262	51	5	362
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ROBO2 SIGLEC11 DCC DSCAML1	1.09e-03	161	51	4	593
GeneFamily	Adenosine receptors\|V-set domain containing	SIGLEC10 SIGLEC14 SIGLEC5 SIGLEC11	1.14e-03	163	51	4	590
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC6B TNRC6C	2.25e-03	25	51	2	775
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	SIGLEC10 SIGLEC11	5.68e-03	40	51	2	592
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	TSPOAP1 TNRC6B TNRC6C HERC1 DSCAML1 MTSS2	6.40e-07	177	77	6	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ABCA4 ICAM5 SIK1 DSCAML1 PLXNB1 SLC22A31	1.31e-06	200	77	6	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Mast\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HS6ST2 NAGA SIGLEC5 C2 RHO	8.58e-06	160	77	5	6393e3d5c5c8176c93aecd89b313bd054a00d474
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Mast-Mast_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HS6ST2 NAGA SIGLEC5 C2 RHO	8.58e-06	160	77	5	2065938e944eb99478fd8132c2c03adeaee6d447
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ASAH1 FOLR3 SIGLEC10 SIK1 C2	1.40e-05	177	77	5	382f0d6bbff01e84b0c7840e74ac865864e6da89
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IRF6 LY75 DSCAML1 ADCY6 HSF5	1.40e-05	177	77	5	4672cc75225a4a23b298afa8ce439628262519db
ToppCell	facs-Lung-EPCAM-24m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPOAP1 TMEM131L LY75 DSCAML1 ADCY6	1.48e-05	179	77	5	51872338e54c5f3e42ca9f1c4cf1e8b0cb84afcc
ToppCell	facs-Lung-EPCAM-24m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPOAP1 TMEM131L LY75 DSCAML1 ADCY6	1.48e-05	179	77	5	1b979e0203a2ddfe98bf6c2c80c4af1ba437a80f
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EPHB4 PCSK5 MFNG FAM181B ITGA5	1.92e-05	189	77	5	360f09f46231a83f99d8fa0158b72a38068e1642
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ASAH1 SIGLEC10 SIK1 C2 ARHGAP21	1.97e-05	190	77	5	0a944da2aaaef9289b2a4ffe360b0338724fd59b
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ABCA4 ICAM5 DSCAML1 PLXNB1 SLC22A31	2.40e-05	198	77	5	b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ABCA4 ICAM5 DSCAML1 PLXNB1 SLC22A31	2.46e-05	199	77	5	a270630626df614f8605abddb7dee7c4d74f6149
Disease	cystatin-8 measurement	FOLR3 C2	6.17e-05	5	74	2	EFO_0801509
Disease	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 measurement	SIGLEC14 SIGLEC5	2.76e-04	10	74	2	EFO_0801544
Disease	sialic acid-binding Ig-like lectin 14 measurement	SIGLEC14 SIGLEC5	4.03e-04	12	74	2	EFO_0008284
Disease	proprotein convertase subtilisin/kexin type 7 measurement	SIK3 DSCAML1	8.24e-04	17	74	2	EFO_0008270
Disease	Age-related macular degeneration	ABCA4 C2	9.25e-04	18	74	2	cv:C0242383
Disease	macular degeneration (is_implicated_in)	ABCA4 C2	2.09e-03	27	74	2	DOID:4448 (is_implicated_in)
Disease	Hypermetropia	TULP4 DSCAML1 ARHGAP21	2.24e-03	103	74	3	HP_0000540
Disease	Retinitis Pigmentosa	ABCA4 AGBL5 RHO	2.30e-03	104	74	3	C0035334

Protein segments in the cluster

Peptide	Gene	Start	Entry
WPLYPPPSHACEDSL	TMEM59L	316	Q9UK28
PSWNCYSRGPLGQPE	AGBL5	856	Q8NDL9
SGPLSPTRWPYHCEV	AGBL3	81	Q8NEM8
SAWGPAPAPATYRAE	ADAD2	41	Q8NCV1
PPVAASYVWDLDPGC	CSMD2	2101	Q7Z408
PGFPSPYSSSQDCVW	CSMD2	2196	Q7Z408
PEYPCGNSTPWKTPS	ABCA4	1451	P78363
DPRSPSAGLWCPVFF	ADCY6	231	O43306
FINPSPLPDLSWGCS	CCNE2	96	O96020
PGPFDWPCFLLTSVG	COX10	181	Q12887
PWTEDCRKSTYPPSG	ASAH1	26	Q13510
DEPPHTCWSSLCGYP	CAPN5	501	O15484
PESDYPPGISCSWHI	PCOLCE	176	Q15113
WPETPPFSYTCGDPS	RIMBP3B	1191	A6NNM3
WPETPPFSYTCGDPS	RIMBP3C	1191	A6NJZ7
NGEECPPASPSTYWA	TSPOAP1	916	O95153
ACAAPPLAGWSRYIP	RHO	166	P08100
CWMPPLPSPSSDYRS	PCDH18	931	Q9HCL0
CCVSGYPPPSFTWLR	DCC	261	P43146
CSLSWPSAEPCNGYP	HOXC12	51	P31275
PDFYPPGSNCTWLID	LRP12	276	Q9Y561
PGPSPSLYCREDGQW	EPHB4	231	P54760
EPGSFVNVSCPWYLP	GLP1R	76	P43220
PAPPRGYFWCNSTLT	ERVFC1-1	351	P60608
WAPGSLLTYSCPQGL	C2	41	P06681
FWSPSDTPLYNLEPC	HERC1	2361	Q15751
SPSEYWDEDAPGCKP	PCSK5	1456	Q92824
VPDLPPLWPGESYSC	PLXNB1	556	O43157
YGPRFEEPSCPSNWT	ICAM5	571	Q9UMF0
PWPGGAQTYSPSSTC	MTSS2	291	Q765P7
CWAPTDPPTGLSYFS	PI4KA	1611	P42356
DPCPEGWQSFPASLS	LY75	641	O60449
QSHVSYPNPWGLPCS	KLKP1	51	Q107X0
QPSPEDELYGQCSPW	FOLR3	46	P41439
GLPAPTAPSGCLSFW	NAGS	176	Q8N159
ISSGCALYPLGWNSP	LHFPL1	131	Q86WI0
QLSFLPPPWGDCSSA	ASIC3	271	Q9UHC3
GNLLYPEPWSVPGCS	FAM181B	316	A6NEQ2
DPSPCGGQSYLWPRH	DDX11	876	Q96FC9
YAAPKAPEATLGPCW	NR0B1	91	P51843
VYLCPWGASPTQCTP	ITGA5	96	P08648
PWSFSSCLEIPEGDP	CARD14	496	Q9BXL6
PCPAAGSPSAALRWY	DSCAML1	46	Q8TD84
LPSCYTGDDWSGCPL	HS6ST2	361	Q96MM7
GFPALFPESPCWLLA	SLC22A31	261	A6NKX4
CLLYPDTPWCPQLGA	MFNG	306	O00587
IGCSAPGYLPTSLAW	WDR77	206	Q9BQA1
VYWSGPCAPSLVAPN	IRF6	321	O14896
SSYPVEFLPSNWPCS	HSF5	346	Q4G112
WSSPTPKCQPGRSYA	SUSD2	771	Q9UGT4
VPQYSSSLWGPPSAD	TNRC6C	1651	Q9HCJ0
TGPLFLPPGCWNIFS	TMEM131L	441	A2VDJ0
AFPDPARPPWYACSS	TMEM151B	286	Q8IW70
WPETPPFSYTCGDPS	RIMBP3	1191	Q9UFD9
APLLPLYDGTKAPWC	SPPL2C	56	Q8IUH8
LPGSCEAGPPLTFSW	SIGLEC5	166	O15389
SGEPLSTWCGSPPYA	SIK1B	176	A0A0B4J2F2
STWCGSPPYAAPEVF	SIK1B	181	A0A0B4J2F2
SGEPLSTWCGSPPYA	SIK1	176	P57059
STWCGSPPYAAPEVF	SIK1	181	P57059
ELLATWCGSPPYAAP	SIK2	171	Q9H0K1
TWCGSPPYAAPELFE	SIK3	221	Q9Y2K2
WSLATDPSYPCLAGP	ATAD3B	596	Q5T9A4
PLSPLSANYSSPLWA	CIPC	281	Q9C0C6
QPPPCYLTAWDGSNF	PREB	276	Q9HCU5
PPVALHPWSSYSACP	TULP4	1256	Q9NRJ4
YPEPGWEAKCPGSSS	WFDC12	91	Q8WWY7
PSAPASEYCPGKLSW	WDR88	21	Q6ZMY6
PSPEASWLCGRYCPT	RP1L1	841	Q8IWN7
PYPCQWGLPTVTAAA	SLC23A1	306	Q9UHI7
WRGPACRPPDSSYNS	TRPV1	616	Q8NER1
WFITPPPCFTAGGLT	TP53INP1	96	Q96A56
AGFAFSCLLTLPPWP	SPCS1	121	Q9Y6A9
ENGYDSDSWCPPLPV	ROBO2	1096	Q9HCK4
KRGSCSPWPDAPTAY	UBP1	306	Q9NZI7
DNSPAYCPPAWGLSQ	XKR5	426	Q6UX68
EECPPPSFSWTGAAL	SIGLEC10	171	Q96LC7
PICYPWLPSAPSAMA	ARHGAP21	201	Q5T5U3
CPAPSFSWTGAALSP	SIGLEC11	186	Q96RL6
LPGSCEAGPPLTFSW	SIGLEC14	166	Q08ET2
SSLNTSLPSPGAWPY	TNRC6B	1531	Q9UPQ9
SLPSPGAWPYSASDN	TNRC6B	1536	Q9UPQ9
SCSWPAYEGGLPPRV	NAGA	186	P17050