Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylcholine floppase activity	ABCA1 ATP8B1	9.80e-05	8	38	2	GO:0090554
GeneOntologyMolecularFunction	phosphatidylserine floppase activity	ABCA1 ATP8B1	1.26e-04	9	38	2	GO:0090556
GeneOntologyMolecularFunction	inhibitory MHC class I receptor activity	LILRA3 LILRB1	2.30e-04	12	38	2	GO:0032396
GeneOntologyMolecularFunction	floppase activity	ABCA1 ATP8B1	4.16e-04	16	38	2	GO:0140328
GeneOntologyMolecularFunction	platelet-derived growth factor receptor binding	PDGFC PDGFRA	4.71e-04	17	38	2	GO:0005161
GeneOntologyMolecularFunction	MHC class I receptor activity	LILRA3 LILRB1	5.29e-04	18	38	2	GO:0032393
GeneOntologyMolecularFunction	phosphatidylcholine transporter activity	ABCA1 ATP8B1	6.56e-04	20	38	2	GO:0008525
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	PKD2L1 LILRA3 ABCA1 ADRA2A HMCN2 PDGFRA PTGER3 LILRB1 GPR139	7.95e-04	1353	38	9	GO:0004888
GeneOntologyMolecularFunction	acid-amino acid ligase activity	GCLM TTLL7	8.70e-04	23	38	2	GO:0016881
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ABCA1 ATP8B1	1.29e-03	28	38	2	GO:0140326
GeneOntologyBiologicalProcess	organic hydroxy compound transport	ABCA1 ATP8B1 ADRA2A SLC44A1 PTGER3 SLC10A7 LILRB1	3.55e-06	358	38	7	GO:0015850
GeneOntologyBiologicalProcess	response to acid chemical	UBR1 PKD2L1 PDGFC PDGFRA GCLM	5.89e-05	228	38	5	GO:0001101
Domain	IGc2	LILRA3 HMCN2 PDGFRA LILRB1	1.56e-03	235	40	4	SM00408
Domain	Ig_sub2	LILRA3 HMCN2 PDGFRA LILRB1	1.56e-03	235	40	4	IPR003598
Domain	Ser-Thr/Tyr_kinase_cat_dom	NEK7 NEK6 PDGFRA	3.19e-03	138	40	3	IPR001245
Pathway	REACTOME_ACTIVATION_OF_NIMA_KINASES_NEK9_NEK6_NEK7	NEK7 NEK6	7.38e-05	7	27	2	M27213
Pubmed	The related murine kinases, Nek6 and Nek7, display distinct patterns of expression.	NEK7 NEK6	1.36e-06	2	41	2	11744387
Pubmed	Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3.	NEK7 NEK6	1.36e-06	2	41	2	11701951
Pubmed	The effect of LILRB1 but not LILRA3 gene polymorphism in immunopathology of ankylosing spondylitis-A parallel to KIR genes.	LILRA3 LILRB1	1.36e-06	2	41	2	30892832
Pubmed	Platelet-derived growth factor C deficiency in C57BL/6 mice leads to abnormal cerebral vascularization, loss of neuroependymal integrity, and ventricular abnormalities.	PDGFC PDGFRA	1.36e-06	2	41	2	22230248
Pubmed	The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.	NEK7 NEK6	1.36e-06	2	41	2	19414596
Pubmed	Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice: evidence for stromal induction of hepatocellular carcinoma.	PDGFC PDGFRA	1.36e-06	2	41	2	23929039
Pubmed	A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6.	NEK7 NEK6	1.36e-06	2	41	2	35354613
Pubmed	Tissue plasminogen activator is a potent activator of PDGF-CC.	PDGFC PDGFRA	4.06e-06	3	41	2	15372073
Pubmed	NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.	NEK7 NEK6	4.06e-06	3	41	2	26642356
Pubmed	Caught Nek-ing: cilia and centrioles.	NEK7 NEK6	4.06e-06	3	41	2	16280549
Pubmed	A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.	NEK7 NEK6	4.06e-06	3	41	2	12840024
Pubmed	Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells.	PDGFC PDGFRA	4.06e-06	3	41	2	12176024
Pubmed	Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis.	PDGFC PDGFRA	4.06e-06	3	41	2	33603171
Pubmed	The PDGF pathway in breast cancer is linked to tumour aggressiveness, triple-negative subtype and early recurrence.	PDGFC PDGFRA	4.06e-06	3	41	2	29380207
Pubmed	Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFD genes.	PDGFC PDGFRA	4.06e-06	3	41	2	11342471
Pubmed	Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A.	PDGFC PDGFRA	8.12e-06	4	41	2	23938297
Pubmed	Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA.	NEK7 NEK6	8.12e-06	4	41	2	10964517
Pubmed	LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence.	LILRA3 LILRB1	8.12e-06	4	41	2	21559424
Pubmed	Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.	PDGFC PDGFRA	8.12e-06	4	41	2	11297552
Pubmed	HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding.	LILRA3 LILRB1	8.12e-06	4	41	2	21270408
Pubmed	A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells.	LILRA3 LILRB1	8.12e-06	4	41	2	9382880
Pubmed	Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.	PDGFC PDGFRA	1.35e-05	5	41	2	20534510
Pubmed	Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.	NEK7 NEK6	1.35e-05	5	41	2	31409757
Pubmed	Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.	NEK7 NEK6	1.35e-05	5	41	2	21642957
Pubmed	PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.	PDGFC PDGFRA	1.35e-05	5	41	2	10806482
Pubmed	A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase.	NEK7 NEK6	1.35e-05	5	41	2	28630147
Pubmed	Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.	UBR1 ADCY3	2.03e-05	6	41	2	17462990
Pubmed	Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways.	LILRA3 LILRB1	2.03e-05	6	41	2	9079806
Pubmed	Regulation of PDGFC signalling and extracellular matrix composition by FREM1 in mice.	PDGFC PDGFRA	2.03e-05	6	41	2	24046351
Pubmed	PDGFs and their receptors.	PDGFC PDGFRA	2.03e-05	6	41	2	28267575
Pubmed	A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex.	PDGFC PDGFRA	2.84e-05	7	41	2	26988758
Pubmed	Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad.	PDGFC PDGFRA	3.78e-05	8	41	2	12651897
Pubmed	Platelet-derived growth factor signals play critical roles in differentiation of longitudinal smooth muscle cells in mouse embryonic gut.	PDGFC PDGFRA	3.78e-05	8	41	2	18194151
Pubmed	A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.	LILRA3 LILRB1	3.78e-05	8	41	2	9548455
Pubmed	Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis.	PDGFC PDGFRA	3.78e-05	8	41	2	19217431
Pubmed	Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development.	PDGFC PDGFRA	4.86e-05	9	41	2	35876806
Pubmed	Role and regulation of PDGFRα signaling in liver development and regeneration.	PDGFC PDGFRA	4.86e-05	9	41	2	23529017
Pubmed	A critical role for PDGFRα signaling in medial nasal process development.	PDGFC PDGFRA	7.41e-05	11	41	2	24086166
Pubmed	A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling.	PDGFC PDGFRA	7.41e-05	11	41	2	15361870
Pubmed	Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression.	SMARCD1 MDN1	1.41e-04	15	41	2	19762545
Pubmed	The familial dysautonomia disease gene IKBKAP is required in the developing and adult mouse central nervous system.	PKD2L1 ADCY3	1.41e-04	15	41	2	28167615
Pubmed	Dysregulated PDGFRα signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification.	PDGFC PDGFRA	1.61e-04	16	41	2	28947535
Pubmed	Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development.	PDGFRA PTGER3	1.61e-04	16	41	2	28439006
Pubmed	Enlarged lateral ventricles and aberrant behavior in mice overexpressing PDGF-B in embryonic neural stem cells.	PDGFC PDGFRA	1.61e-04	16	41	2	20643125
Pubmed	Srsf3 mediates alternative RNA splicing downstream of PDGFRα signaling in the facial mesenchyme.	PDGFC PDGFRA	3.09e-04	22	41	2	34184034
Pubmed	Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.	PDGFC PDGFRA GCLM	3.43e-04	115	41	3	20485444
Pubmed	Genome-wide association study of hematological and biochemical traits in a Japanese population.	SLC2A9 PDGFRA AK3	3.51e-04	116	41	3	20139978
Pubmed	Extension of conserved regions in the rat and mouse genomes by chromosomal assignments of 29 rat genes.	ADRA2A PTGER3	3.68e-04	24	41	2	9606417
Pubmed	The Fgf9-Nolz1-Wnt2 axis regulates morphogenesis of the lung.	PDGFC PDGFRA	9.28e-04	38	41	2	37497597
Pubmed	Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production.	CDH26 MSTN	1.08e-03	41	41	2	25810521
Cytoband	1p32.3	MROH7 SSBP3-AS1	1.38e-03	61	41	2	1p32.3
Cytoband	19q13.4	LILRA3 LILRB1	2.30e-03	79	41	2	19q13.4
Cytoband	Ensembl 112 genes in cytogenetic band chr9q31	ABCA1 SLC44A1	6.72e-03	137	41	2	chr9q31
Cytoband	Ensembl 112 genes in cytogenetic band chr2p23	OTOF ADCY3	7.90e-03	149	41	2	chr2p23
Cytoband	Ensembl 112 genes in cytogenetic band chr1p32	MROH7 SSBP3-AS1	8.52e-03	155	41	2	chr1p32
Cytoband	Ensembl 112 genes in cytogenetic band chr4q31	TMEM184C SLC10A7	9.49e-03	164	41	2	chr4q31
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	LILRA3 SLC44A1 PDGFRA LILRB1	2.62e-03	394	27	4	471
GeneFamily	Solute carriers	SLC44A1 SLC2A9 SLC10A7	2.05e-02	395	27	3	752
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	HMCN2 PDGFRA	2.39e-02	161	27	2	593
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PKD2L1 SLC2A9 PDGFC TEX2 ADCY3	8.01e-07	188	41	5	d7a9fb5b021e127b8d927658a55a71098d513b5c
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MROH7 CDH26 FBXL13 PCNX3	1.48e-05	162	41	4	80619a93c57fe16daf91dc571874ef9ac888953d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HMCN2 SLC2A9 CTRB1 NPIPB2	1.59e-05	165	41	4	3c8baed838eccb6e720bacb7458f087647dc1222
ToppCell	droplet-Spleen-nan-18m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXL13 NEK6 PDGFRA TEX2	1.83e-05	171	41	4	4e856441063e9825b6f87a1d3dd19c77dae4662c
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	UBR1 ARMCX5 TEX2 ADCY3	1.91e-05	173	41	4	efb8072475000888efe088d00e870c56ffad4172
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	UBR1 ARMCX5 TEX2 ADCY3	1.96e-05	174	41	4	58300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCell	Immune_cells-Dendritic_cells\|Immune_cells / Lineage and Cell class	SLC44A1 FBXL13 NEK6 TEX2	2.33e-05	182	41	4	99c7d4f1e7cd745643ba64b59190113bcd4e348e
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABCA1 NEK6 PDGFC ADCY3	2.49e-05	185	41	4	4bee178ede12f56ba5f5bec44a03dc2a62c50137
ToppCell	megakaryocytic-CD34+_Megakaryoblast\|World / Lineage and Cell class	CDH26 ADRA2A SLC44A1 PTGER3	2.76e-05	190	41	4	1d19b2bd55789bf13e1386332f46c605973d6f8e
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP8B1 ADRA2A TTLL7 COPB2	2.82e-05	191	41	4	f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCell	mild_COVID-19_(asymptomatic)\|World / disease group, cell group and cell class (v2)	JARID2 ABCA1 OTOF LILRB1	3.12e-05	196	41	4	8cb3dcb3e5732f4bb060c87ca339b8997a1a8cd4
Disease	membranous glomerulonephritis (biomarker_via_orthology)	ABCA1 PTGER3	1.46e-04	14	38	2	DOID:10976 (biomarker_via_orthology)
Disease	ceramide measurement	PKD2L1 ABCA1 ATP8B1 MDN1	2.34e-04	235	38	4	EFO_0010222
Disease	familial hyperlipidemia (biomarker_via_orthology)	SMARCD1 ABCA1	2.72e-04	19	38	2	DOID:1168 (biomarker_via_orthology)
Disease	gluteofemoral adipose tissue measurement	ABCA1 SLC44A1 PDGFC	6.58e-04	132	38	3	EFO_0803317
Disease	Schizophrenia	APOL4 JARID2 ABCA1 ADRA2A PTGER3 LILRB1	8.60e-04	883	38	6	C0036341
Disease	cervical cancer	JARID2 PDGFC	1.22e-03	40	38	2	MONDO_0002974
Disease	oral microbiome measurement	SLC2A9 PDZD2	1.35e-03	42	38	2	EFO_0801229
Disease	interleukin 7 measurement	LILRB1 PDZD2	1.54e-03	45	38	2	EFO_0008189
Disease	HOMA-B	ABCA1 ADRA2A	2.30e-03	55	38	2	EFO_0004469
Disease	low density lipoprotein particle size measurement	PKD2L1 ABCA1	2.55e-03	58	38	2	EFO_0008593

Protein segments in the cluster

Peptide	Gene	Start	Entry
RQWIRPLVAVIYLVS	TMEM184C	11	Q9NVA4
LIAWRYVPINVVETL	APOL4	261	Q9BPW4
YLPSQVSRVVKLWRE	COPB2	761	P35606
WLLRYSVIVKSRGII	GCLM	246	P48507
IWELLLKYRQGRTII	ABCA1	1071	O95477
KIWRPVEIFRLVSKY	DIPK2B	106	Q9H7Y0
VIAWSRARYIVLVPV	ARMCX5	221	Q6P1M9
RQPYIWLTIILAVAV	ATP8B1	1141	O43520
VPVRWVVKVVKTLLL	MROH7	901	Q68CQ1
TYPRNTVLVWRLVAV	PDGFC	66	Q9NRA1
SLIVLVVIWKQKPRY	PDGFRA	541	P16234
QKPRYEIRWRVIESI	PDGFRA	551	P16234
LIIGQIVRRYIKDWL	SLC10A7	181	Q0GE19
IWLRRTKPSKRQYQI	MDN1	5371	Q9NU22
VLVVTIAPIYWALAR	HMCN2	4446	Q8NDA2
VPFEVIKQRLTARWI	AK3	116	Q9UIJ7
KLRFVLTYIAPWQIT	PCNX3	1241	Q9H6A9
WRLIRPSVISIIGLY	PDZD2	576	O15018
TTPVVIVVYLSKQRW	PTGER3	106	P43115
RLIPERTVWKYFVQL	NEK7	131	Q8TDX7
KRLIPERTVWKYFVQ	NEK6	141	Q9HC98
RRVLPYVLWLLITAQ	ADCY3	136	O60266
VIPDKYIVSTLQRWR	FBXL13	206	Q8NEE6
YQPLRRSKRRWVITT	CDH26	46	Q8IXH8
LVSVLELLRAPYVRW	SLC2A9	301	Q9NRM0
ELLRAPYVRWQVVTV	SLC2A9	306	Q9NRM0
VIIRYISRVLVWILT	SLC44A1	231	Q8WWI5
IWITVPLTIDRYIAV	GPR139	116	Q6DWJ6
YARVTKLIPWVQKIL	CTRB1	246	P17538
YREKKTALWITRIPQ	LILRA3	61	Q8N6C8
IRPVLSKYRVEVLFW	OTOF	1126	Q9HC10
IPWSEERVVRKVLYL	JARID2	21	Q92833
IVLVVLRIWYTSLNP	CWH43	131	Q9H720
TRPVIIQALWQYIKT	SMARCD1	311	Q96GM5
YREKKTALWITRIPQ	LILRB1	61	Q8NHL6
VVKAQLWIYLRPVET	MSTN	151	O14793
WIGRLKRRQIYVIST	SKIV2L	466	Q15477
VLKARWLVTPVRTLA	SSBP3-AS1	6	Q7Z2R9
TPRRIKAIIITVWVI	ADRA2A	161	P08913
YILISKPTIWTERLR	UBR1	481	Q8IWV7
IPSWQIRTVKLIRYV	PKD2L1	331	Q9P0L9
WLRIIIAFPRSYKVV	NPIPB2	41	A6NJ64
IYLVPKTLARKRIWN	TEX2	616	Q8IWB9
VKTSIRTVLPRIWKV	TTLL7	741	Q6ZT98