Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainDAGK_acc

DGKG DGKQ

6.64e-0410732PF00609
DomainDiacylglycerol_kin_accessory

DGKG DGKQ

6.64e-0410732IPR000756
DomainDAGKa

DGKG DGKQ

6.64e-0410732SM00045
DomainDAGKc

DGKG DGKQ

1.33e-0314732SM00046
DomainDiacylglycerol_kinase_cat_dom

DGKG DGKQ

1.53e-0315732IPR001206
DomainDAGK_cat

DGKG DGKQ

1.53e-0315732PF00781
DomainDAGK

DGKG DGKQ

1.53e-0315732PS50146
DomainLRR_1

RNH1 MFHAS1 LRRC28 FBXL19 LRRC30

1.67e-03219735PF00560
DomainNAD/diacylglycerol_kinase

DGKG DGKQ

1.97e-0317732IPR016064
DomainARM-type_fold

UPF2 CLASP1 AOPEP MROH7 COPG2 TRRAP

2.10e-03339736IPR016024
DomainLeu-rich_rpt_Cys-con_subtyp

RNH1 FBXL19

2.47e-0319732IPR006553
DomainLRR_CC

RNH1 FBXL19

2.47e-0319732SM00367
DomainHEAT_REPEAT

CLASP1 MROH7 COPG2

2.60e-0370733PS50077
DomainLeu-rich_rpt

RNH1 MFHAS1 LRRC28 FBXL19 LRRC30

4.17e-03271735IPR001611
Pubmed

Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions.

DGKG DGKQ

1.45e-05377210206945
Pubmed

MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer.

MTSS1 RECK

2.89e-05477223383207
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DGCR2 MFHAS1 HECTD4 DGKQ FBXL19 IDUA TRRAP GBA2 IQGAP3 RYR1 DHX30

3.11e-051105771135748872
Pubmed

Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.

MTSS1 C2orf80 RYR1

4.06e-053077320080650
Pubmed

Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases.

DGKG DGKQ

4.82e-05577222627129
Pubmed

LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.

AOPEP SYNE1

4.82e-05577222632968
Pubmed

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts.

HDAC5 MTSS1

7.22e-05677220181743
Pubmed

Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene.

DGKG DGKQ

7.22e-0567727607687
Pubmed

TRIM65 regulates microRNA activity by ubiquitination of TNRC6.

UPF2 RECQL4 POP1 PRR14L TRRAP IQGAP3

1.60e-0436477624778252
Pubmed

Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.

MFHAS1 POP1

1.72e-04977222210626
Pubmed

Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.

DGKG DGKQ

2.63e-041177217021016
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

PTBP3 UPF2 CLASP1 WDR7 ZNF618 SYNE1 HECTD4 TRRAP DHX30

6.40e-04108277938697112
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

CLASP1 ZNF618 SYNE1 TRRAP

8.06e-0418777426460568
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

RNH1 UPF2 PGLS COPG2 TRRAP IQGAP3 DHX30

9.54e-0470477729955894
Pubmed

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

STAB2 MTSS1 MDGA2 RECK

1.02e-0319977423382691
Pubmed

Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.

RNH1 COPG2 TRRAP IQGAP3

1.26e-0321177417314511
Pubmed

AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.

UPF2 TRRAP

1.89e-032977220371770
Pubmed

Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.

RFTN2 DHX30

1.89e-032977221266579
Pubmed

Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.

ZNF618 SH2D3C

2.02e-033077220583170
Pubmed

Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.

CLPP PTBP3 RNH1

2.05e-0311377323403292
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

HDAC5 CLASP1 WDR7 SYNE1 DHX30

2.12e-0340777512693553
GeneFamilyEF-hand domain containing|Diacylglycerol kinases

DGKG DGKQ

2.69e-04104521178
Diseasealpha-L-iduronidase measurement

DGKQ IDUA

8.68e-0417762EFO_0020139
Diseaseprion disease

MFHAS1 POP1

1.09e-0319762EFO_0004720
Diseasefactor VIII measurement, Ischemic stroke

STAB2 HECTD4

1.09e-0319762EFO_0004630, HP_0002140
Diseasecongestive heart failure (is_implicated_in)

AGXT2 RYR1

2.20e-0327762DOID:6000 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
ETLPLCRVQPITSSH

TDRD1

1031

Q9BXT4
RHLLRPLCLVTSAPR

AGXT2

6

Q9BYV1
ICLPVERLSRITPVL

BBS7

151

Q8IWZ6
IKVPRVSSLCLSLHP

C2orf80

121

Q0P641
RTHLLSRLPIPESQV

PGLS

96

O95336
RTLPLHTSILPKEIC

COQ10B

46

Q9H8M1
SPVLRLSPCLHRSLE

FAM117A

201

Q9C073
RFITLLPHVPRCTAA

CYP2W1

356

Q8TAV3
LKHVRIPCTSVAPSL

DGKQ

101

P52824
LLRLIPPCLSAAHSV

AOPEP

416

Q8N6M6
VTERRPLHTVVLSLP

CCM2

36

Q9BSQ5
TPCHLRSPETIFRQR

LINC01600

106

Q96MT4
LHPLLVVVSCLTRDP

DHX30

896

Q7L2E3
ARVTRRPFTPIHSCI

CCDC60

126

Q8IWA6
HLLTAPTSPLRETLV

FBXL19

616

Q6PCT2
HCISRPSSKALLIPT

MROH7

191

Q68CQ1
LLTSVLPTPVLRHDS

RFTN2

371

Q52LD8
RARPSCHSLLLPLSL

RECK

946

O95980
PARPDHTRLLQICLL

PCDHGA4

36

Q9Y5G9
PATLHCRLLRTPLAT

MAP10

101

Q9P2G4
HRLQILSPVLPVSCR

MFHAS1

616

Q9Y4C4
LVCLRTLPSRVFHPA

GHITM

6

Q9H3K2
LLIRRHTLPTCSLLI

NLRP10

276

Q86W26
HTLPTCSLLITTRPL

NLRP10

281

Q86W26
RLRHLPSPISVAQCL

GGNBP1

81

Q5YKI7
VPRPRTLLEICLHHN

ASB12

211

Q8WXK4
LLVTLDPRLCHPLAR

GDF1

236

P27539
TARKLTVHLRPPASC

MAPK8IP2

711

Q13387
LVATLRHCLLPVLSR

KCNK7

136

Q9Y2U2
ITDPFVCRLRHLSPT

OR4A15

11

Q8NGL6
HCLPASRLLPRVTSV

MTSS1

371

O43312
AAHFITRLVRTCLPP

NPEPL1

91

Q8NDH3
RAHLLPSKACRLRTP

PEAK3

31

Q6ZS72
LPPLVLRVAASRCLH

LMLN2

11

A0A1B0GTW7
ICSPLRLINIRHPIS

MRGPRX3

81

Q96LB0
CVPRSEALPLHKLSI

HECTD4

1801

Q9Y4D8
CTAQTPEPLRRHRSL

IQGAP3

1411

Q86VI3
ETLELTCLVTGHPRP

MDGA2

56

Q7Z553
PLPRVTLHCSRTLLG

POP1

951

Q99575
HILLPTSICPITRDR

DGKG

391

P49619
PSTDPLVVTCLERRH

GCNT7

386

Q6ZNI0
VTLTCRQITPILPHD

GBA2

246

Q9HCG7
TSPHIRCASLLLVPK

DCST1

96

Q5T197
VHPRAPELTLSLLTT

DYTN

81

A2CJ06
SPLLSLCHPDIIRSV

CYP4F2

96

P78329
ETPINPRRCLHILTK

COPG2

36

Q9UBF2
RLPSLLLVHVCARPE

IDUA

531

P35475
LVLTVTEPLRPELRC

DGCR2

16

P98153
RCRPPSVLLISELEA

FIGNL2

481

A6NMB9
SLEILPRTSLHSIPV

HDAC5

16

Q9UQL6
GTVDTPPCLRLTHRT

RYR1

1261

P21817
TLPSELHLLCRLVRI

LRRC30

246

A6NM36
PIPTKAHRLLSLCTL

PRR14L

1556

Q5THK1
DPPEHLFRIRLVCTI

UPF2

911

Q9HAU5
LPRSELHKLISPLQC

MAP3K14

221

Q99558
LTCLPFCRTRIIPHT

OR52H1

171

Q8NGJ2
LRIPEDVVASLPLCH

SYNE1

5696

Q8NF91
SPISLPRSLLELLHC

LRRC28

296

Q86X40
TVLICLRLSLGPRTH

LILRA1

6

O75019
RRSPCLTLVVSPLLS

RECQL4

521

O94761
CAPLPRDRLQHTLVS

KBTBD4

311

Q9NVX7
PCILDSSLLKPRSHL

FAM178B

276

Q8IXR5
RCLHATATRALPLIP

CLPP

46

Q16740
HIPRLIPVITSNCTS

CLASP1

441

Q7Z460
SRCQLHLLPSRRSVP

PREB

376

Q9HCU5
VVSPLSTLRVPTLRC

XCR1

131

P46094
ASVVRCATLLHRTPP

ZNF618

326

Q5T7W0
TILPPEIQARVRHRC

ZNF174

96

Q15697
TLTVSLCTAPIPRKH

SLC5A2

541

P31639
ILSRALEVSPPRCLV

SLC26A11

501

Q86WA9
ELCPGLLHPSSRLRT

RNH1

246

P13489
SIVPILPHRCDETKR

STAB2

656

Q8WWQ8
SPSRVLHLRKIPCDV

PTBP3

56

O95758
DCPTIRVPLTSLKSH

WDR37

266

Q9Y2I8
TTFPHVLPLITLLEC

SH2D3C

741

Q8N5H7
IRPRRCDHVPSTLHI

VRTN

206

Q9H8Y1
LPPHSTIRRTAIDLI

WDR7

1191

Q9Y4E6
LSRIHTIPTVPIVDC

TRRAP

3061

Q9Y4A5
ALTLPRRPFLHCSTV

TMEM267

106

Q0VDI3