Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainATPase_dyneun-rel_AAA

MDN1 DNAH11

5.30e-0414462IPR011704
DomainAAA_5

MDN1 DNAH11

5.30e-0414462PF07728
DomainLRR_8

LRCH2 SLITRK3 ELFN2

8.58e-03171463PF13855
DomainLeu-rich_rpt_typical-subtyp

LRCH2 SLITRK3 ELFN2

9.42e-03177463IPR003591
DomainLRR_TYP

LRCH2 SLITRK3 ELFN2

9.42e-03177463SM00369
Pubmed

TAO kinases mediate activation of p38 in response to DNA damage.

TAOK2 TAOK3

5.83e-06349217396146
Pubmed

Expression of Ku70 and Ku80 mediated by NF-kappa B and cyclooxygenase-2 is related to proliferation of human gastric cancer cells.

XRCC5 PTGS2

5.83e-06349212324457
Pubmed

DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis.

XRCC5 PTGS2

5.83e-06349235910805
Pubmed

Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells.

KAT2B PTGS2

1.16e-05449222335196
Pubmed

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.

KAT2B XRCC5

1.94e-05549215023334
Pubmed

Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.

TAOK2 TAOK3

1.94e-05549213679851
Pubmed

Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription.

KAT2B TTF1

2.91e-05649211250901
Pubmed

Expression of testicular germ cell genes identified by differential display analysis.

POLD3 ANKRD18B

5.42e-05849212634303
Pubmed

A role of DNA-PK for the metabolic gene regulation in response to insulin.

KAT2B XRCC5

8.69e-051049219303849
Pubmed

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

TAOK3 MDN1 PHF3 SF3B6 XRCC5

1.16e-0434049529478914
Pubmed

Dynamic protein-protein interaction wiring of the human spliceosome.

SNRNP27 CHERP SF3B6 NSRP1

1.73e-0419749422365833
Pubmed

Nsp2 has the potential to be a drug target revealed by global identification of SARS-CoV-2 Nsp2-interacting proteins.

EXOC6 THNSL1 DYNC2I1

2.31e-048449334159380
Pubmed

The protein interaction landscape of the human CMGC kinase group.

SNRNP27 CHERP PHF3 CILK1 NEB NSRP1

4.20e-0469549623602568
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

MDN1 SF3B6 SEC22B

4.33e-0410449331240132
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

EXOC6 LRCH2 SEC22B XRCC5

4.35e-0425149429778605
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

MDN1 CHERP PHF3 SF3B6

4.35e-0425149428077445
Pubmed

Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.

CEP104 CHERP

4.41e-042249226420826
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

MDN1 CHERP PHF3 SF3B6 XRCC5 PTGS2 NSRP1

4.46e-0498949736424410
Pubmed

An integrative method for scoring candidate genes from association studies: application to warfarin dosing.

EXOC6 F8

6.67e-042749221044367
Pubmed

Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.

XRCC5 PTGS2

7.18e-042849219661089
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

GGH SNRNP27 CHERP LRCH2 SF3B6 XRCC5 NSRP1

7.60e-04108249738697112
Pubmed

Integrating genetic and network analysis to characterize genes related to mouse weight.

SCN7A NEB

7.71e-042949216934000
Pubmed

A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.

POLD3 XRCC5

8.81e-043149212171929
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

GGH TAOK3 CHERP PIGS SF3B6 SEC11C SEC22B ME3

8.84e-04145149830550785
Pubmed

Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.

CHERP SF3B6

1.06e-033449212234937
Pubmed

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.

LIPG DNAH11

1.06e-033449219060911
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

TAOK2 CHERP PHF3 SF3B6 XRCC5

1.35e-0358349529844126
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

CHERP PHF3 PIGS RNF216 SEC22B XRCC5 NSRP1

1.41e-03120349729180619
Cytoband6q15

MDN1 AKIRIN2

5.09e-04314926q15
CytobandEnsembl 112 genes in cytogenetic band chr6q15

MDN1 AKIRIN2

1.38e-0351492chr6q15
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

TAOK2 TAOK3

5.38e-0424262654
Diseaseintermittent Staphylococcus aureus carrier status

KAT2B CILK1

8.88e-059472EFO_0007758
Diseasecentral nervous system disease (implicated_via_orthology)

TAOK2 TAOK3

2.94e-0416472DOID:331 (implicated_via_orthology)
DiseaseAdenocarcinoma of lung (disorder)

TAOK3 XRCC5 TTF1 CMTR2

3.25e-04206474C0152013
Diseasecardiovascular system disease (is_implicated_in)

LIPG PTGS2

5.12e-0421472DOID:1287 (is_implicated_in)
DiseaseAlcoholic Intoxication, Chronic

GGH PHF3 XRCC5 ANKRD7

8.73e-04268474C0001973
Diseasehypertension (implicated_via_orthology)

LIPG KCNQ1 PTGS2

1.12e-03128473DOID:10763 (implicated_via_orthology)
DiseaseBladder Neoplasm

GGH PTGS2 SMC1B

1.45e-03140473C0005695
DiseaseMalignant neoplasm of urinary bladder

GGH PTGS2 SMC1B

1.48e-03141473C0005684
DiseaseCarcinoma, Transitional Cell

GGH PTGS2

1.96e-0341472C0007138
Diseaseasthma exacerbation measurement, response to corticosteroid

ME3 DNAH11

3.01e-0351472EFO_0007614, GO_0031960

Protein segments in the cluster

PeptideGeneStartEntry
KLIYYRAKKMFDVNN

TTF1

601

Q15361
RAKKMFDVNNYKGRY

TTF1

606

Q15361
MEQEYNKQKSKYLRG

ALKBH8

506

Q96BT7
ILYNIKQEYKRMQKR

AKIRIN2

81

Q53H80
RNKELMNEYNYLKEK

ANKRD18B

601

A2A2Z9
QRNKYFKTYNERKML

CMTR2

436

Q8IYT2
NYRKKLASYFMGRKL

DNAH11

436

Q96DT5
NYRMKSYKNKALNPQ

KPNA5

11

O15131
MKVRKERYENNDKYR

NSRP1

421

Q9H0G5
VIRRMQYFVAKKKFQ

KCNQ1

516

P51787
YQKNELKIYDRMKAK

MDN1

1681

Q9NU22
RLKNRYYVSKKLFMA

KAT2B

776

Q92831
YDMYIRNFGKKNTKQ

DYNC2I1

516

Q8WVS4
YNAKKMRNKRNSKMY

LIPG

321

Q9Y5X9
SRQMKYQSFNEYRKR

PTGS2

441

P35354
QRIGRKYKKVRFMAY

F8

436

P00451
TFENYYRKQRKKQAR

EXOC6

301

Q8TAG9
RVAAYNKKKKRMDYY

PAPSS1

561

O43252
YDLAKEKKQQMEQYR

CEP104

266

O60308
NYRRNKSYSFIARMK

CHERP

896

Q8IWX8
KYNKDSKMYRALQTV

CYP46A1

101

Q9Y6A2
QKCRNKVMKNYGRYY

GGH

41

Q92820
RQQKTDMQYAAKVYR

DNAJB14

336

Q8TBM8
QYMERYGKRLKAKNL

DDX11L8

426

A8MPP1
FMQERQKRYAKYAEQ

BORCS5

131

Q969J3
QIKKYDVNMQDKKYR

ANKRD7

46

Q92527
NAFRLLNKYRNKYCM

ME3

286

Q16798
DSMLQKYKVKNAYRL

FAM167A-AS1

71

Q96KT0
LSKKYRQDAKYLNMR

SEC22B

176

O75396
RQDAKYLNMRSTYAK

SEC22B

181

O75396
SKQIRKEYFKYKSMR

LRCH2

556

Q5VUJ6
YKMKIKCRFQKAYRR

PIGS

96

Q96S52
DLKKMNKRQLYYQVL

SEC11C

21

Q9BY50
RKNYKALCQMYEKIQ

TBC1D21

91

Q8IYX1
VSQKRKYRQYMNRKG

SNRNP27

131

Q8WVK2
KLYLQRNSMRKLYTN

SLITRK3

81

O94933
RQYFELQCRQYKRKM

TAOK2

636

Q9UL54
LYYDKNCRFFKRKIM

TAOK3

606

Q9H2K8
RKKRKQMNQYSYIDF

RNF216

426

Q9NWF9
QAKQMLYDYVERKRK

POLD3

36

Q15054
YMKENLYQLIKERNK

CILK1

81

Q9UPZ9
KMYYLNKSKRNQESL

ZNF804B

861

A4D1E1
KRYFYKKMLTRLNVQ

SMC1B

806

Q8NDV3
ARYLQRKAAKMYTDK

TMIE

91

Q8NEW7
YYNANRAFQKMDTKK

SF3B6

91

Q9Y3B4
RDTDAKYKNKYRSLM

PHF3

971

Q92576
KYKNKYRSLMFNLKD

PHF3

976

Q92576
SMKDLLKFRRQYYKK

THNSL1

181

Q8IYQ7
KQYRRLKKLMYEDSQ

SCN7A

1216

Q01118
RQYMFSSLKNSKKYA

XRCC5

431

P13010
YYCLRKRRMQEEKQK

ELFN2

416

Q5R3F8
MQSDREYKKNYENTK

NEB

2096

P20929
MNEKKYRADYEQRKD

NEB

5401

P20929