Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionendopeptidase activity

KLK11 KLK7 ADAMTS2 ADAMTS9 KLK14 ADAMTS20 MMP9 CTRB1 KLK13 KLK1

1.98e-074305410GO:0004175
GeneOntologyMolecularFunctionserine-type endopeptidase activity

KLK11 KLK7 KLK14 MMP9 CTRB1 KLK13 KLK1

7.67e-07190547GO:0004252
GeneOntologyMolecularFunctionserine-type peptidase activity

KLK11 KLK7 KLK14 MMP9 CTRB1 KLK13 KLK1

1.36e-06207547GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

KLK11 KLK7 KLK14 MMP9 CTRB1 KLK13 KLK1

1.60e-06212547GO:0017171
GeneOntologyMolecularFunctionpeptidase activity

KLK11 KLK7 ADAMTS2 ADAMTS9 KLK14 ADAMTS20 MMP9 CTRB1 KLK13 KLK1

8.63e-066545410GO:0008233
GeneOntologyMolecularFunctionmetalloendopeptidase activity

KLK7 ADAMTS2 ADAMTS9 ADAMTS20 MMP9

1.80e-05120545GO:0004222
GeneOntologyMolecularFunctionmetallopeptidase activity

KLK7 ADAMTS2 ADAMTS9 ADAMTS20 MMP9

2.04e-04200545GO:0008237
GeneOntologyMolecularFunctionphosphatidic acid binding

RAPGEF2 PLEKHN1

1.91e-0324542GO:0070300
GeneOntologyBiologicalProcessextracellular matrix organization

KLK7 ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 MMP9 ADAMTSL4

5.45e-05377547GO:0030198
GeneOntologyBiologicalProcessextracellular structure organization

KLK7 ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 MMP9 ADAMTSL4

5.54e-05378547GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

KLK7 ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 MMP9 ADAMTSL4

5.64e-05379547GO:0045229
GeneOntologyBiologicalProcesspositive regulation of melanocyte differentiation

ADAMTS9 ADAMTS20

6.69e-055542GO:0045636
GeneOntologyBiologicalProcesspositive regulation of pigment cell differentiation

ADAMTS9 ADAMTS20

1.40e-047542GO:0050942
GeneOntologyBiologicalProcessregulation of melanocyte differentiation

ADAMTS9 ADAMTS20

1.40e-047542GO:0045634
GeneOntologyBiologicalProcesspigment cell differentiation

ADAMTS9 ADAMTS20 ADAMTSL4

1.56e-0440543GO:0050931
GeneOntologyBiologicalProcesspositive regulation of developmental pigmentation

ADAMTS9 ADAMTS20

2.39e-049542GO:0048087
GeneOntologyBiologicalProcessmicrotubule severing

TTLL11 LZTS2

2.39e-049542GO:0051013
GeneOntologyBiologicalProcessregulation of pigment cell differentiation

ADAMTS9 ADAMTS20

2.39e-049542GO:0050932
GeneOntologyBiologicalProcesspigmentation

ADAMTS9 ADAMTS20 SHROOM2 ADAMTSL4

3.22e-04125544GO:0043473
GeneOntologyCellularComponentextracellular matrix

CCN4 ADAMTSL1 ADAMTS2 SFTPB ADAMTS9 ADAMTS20 MMP9 ADAMTSL4

2.62e-04656548GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

CCN4 ADAMTSL1 ADAMTS2 SFTPB ADAMTS9 ADAMTS20 MMP9 ADAMTSL4

2.68e-04658548GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

ADAMTSL1 ADAMTS2 SFTPB ADAMTS9 ADAMTS20 MMP9 ADAMTSL4

4.09e-04530547GO:0062023
HumanPhenoSpontaneous neonatal pneumothorax

ADAMTS2 SFTPB

3.14e-053172HP:0004876
MousePhenofailure of initiation of embryo turning

DNAAF2 NUMB MESP1 CUBN

2.78e-0556444MP:0004180
MousePhenodelayed embryo turning

NUMB MESP1 RAPGEF2

4.93e-0523443MP:0004188
DomainTSP_1

CCN4 ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 ADAMTSL4

1.85e-0863516PF00090
DomainTSP1

CCN4 ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 ADAMTSL4

2.24e-0865516SM00209
DomainTSP1_rpt

CCN4 ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 ADAMTSL4

2.24e-0865516IPR000884
DomainTSP1

CCN4 ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 ADAMTSL4

2.24e-0865516PS50092
DomainTRYPSIN_SER

KLK11 KLK7 KLK14 CTRB1 KLK13 KLK1

1.60e-0790516IPR033116
DomainTRYPSIN_HIS

KLK11 KLK7 KLK14 CTRB1 KLK13 KLK1

3.58e-07103516IPR018114
DomainADAM_spacer1

ADAMTS2 ADAMTS9 ADAMTS20 ADAMTSL4

4.20e-0723514IPR010294
DomainADAM_spacer1

ADAMTS2 ADAMTS9 ADAMTS20 ADAMTSL4

4.20e-0723514PF05986
DomainTRYPSIN_SER

KLK11 KLK7 KLK14 CTRB1 KLK13 KLK1

4.24e-07106516PS00135
DomainTRYPSIN_HIS

KLK11 KLK7 KLK14 CTRB1 KLK13 KLK1

4.48e-07107516PS00134
DomainPeptidase_M12B_ADAM-TS

ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20

5.03e-0724514IPR013273
DomainPeptidase_S1A

KLK11 KLK7 KLK14 CTRB1 KLK13 KLK1

6.19e-07113516IPR001314
DomainTRYPSIN_DOM

KLK11 KLK7 KLK14 CTRB1 KLK13 KLK1

6.87e-07115516PS50240
DomainTryp_SPc

KLK11 KLK7 KLK14 CTRB1 KLK13 KLK1

7.60e-07117516SM00020
DomainTrypsin

KLK11 KLK7 KLK14 CTRB1 KLK13 KLK1

9.26e-07121516PF00089
DomainTrypsin_dom

KLK11 KLK7 KLK14 CTRB1 KLK13 KLK1

9.26e-07121516IPR001254
DomainPeptidase_S1_PA

KLK11 KLK7 KLK14 CTRB1 KLK13 KLK1

1.02e-06123516IPR009003
DomainPept_M12B_GON-ADAMTSs

ADAMTS9 ADAMTS20

7.31e-062512IPR012314
DomainGON

ADAMTS9 ADAMTS20

7.31e-062512PF08685
DomainGON

ADAMTS9 ADAMTS20

7.31e-062512PS51046
DomainPLAC

ADAMTSL1 ADAMTS2 ADAMTSL4

1.80e-0519513IPR010909
DomainPLAC

ADAMTSL1 ADAMTS2 ADAMTSL4

1.80e-0519513PS50900
DomainMetalloPept_cat_dom

ADAMTS2 ADAMTS9 ADAMTS20 MMP9

7.03e-0581514IPR024079
Domain-

ADAMTS2 ADAMTS9 ADAMTS20 MMP9

7.03e-05815143.40.390.10
DomainZINC_PROTEASE

ADAMTS2 ADAMTS9 ADAMTS20 MMP9

1.47e-0498514PS00142
DomainPeptidase_M12B_N

ADAMTS2 ADAMTS9 ADAMTS20

1.64e-0439513IPR002870
DomainPep_M12B_propep

ADAMTS2 ADAMTS9 ADAMTS20

1.64e-0439513PF01562
DomainDISINTEGRIN_1

ADAMTS2 ADAMTS9 ADAMTS20

1.76e-0440513PS00427
DomainADAM_MEPRO

ADAMTS2 ADAMTS9 ADAMTS20

1.76e-0440513PS50215
DomainDISINTEGRIN_2

ADAMTS2 ADAMTS9 ADAMTS20

1.76e-0440513PS50214
DomainReprolysin

ADAMTS2 ADAMTS9 ADAMTS20

1.76e-0440513PF01421
DomainPeptidase_M12B

ADAMTS2 ADAMTS9 ADAMTS20

1.76e-0440513IPR001590
DomainDisintegrin_dom

ADAMTS2 ADAMTS9 ADAMTS20

1.90e-0441513IPR001762
DomainRuvA_2-like

SRBD1 FANCM

2.60e-049512IPR010994
DomainPLAC

ADAMTSL1 ADAMTSL4

6.51e-0414512PF08686
DomainCYSTEINE_SWITCH

ADAMTS9 MMP9

5.60e-0341512PS00546
DomainPept_M10_metallopeptidase

ADAMTS9 MMP9

6.15e-0343512IPR001818
DomainCUB

CUBN CSMD3

7.92e-0349512PF00431
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 ADAMTSL4

5.83e-0839385M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 ADAMTSL4

5.83e-0839385MM15165
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 ADAMTSL4

9.98e-0768385M27303
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTSL1 ADAMTS2 SFTPB ADAMTS9 ADAMTS20 CUBN ADAMTSL4

4.00e-06250387M27554
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 ADAMTSL4

1.03e-05109385MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 ADAMTSL4

1.13e-05111385M27416
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 ADAMTSL4

3.84e-05143385M27275
PathwayWP_HAIR_FOLLICLE_DEVELOPMENT_CYTODIFFERENTIATION_STAGE_3_OF_3

KLK7 KLK14 ADAMTS20 KLK13

8.51e-0587384M39465
PathwayREACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES

MMP9 CTRB1 KLK1

1.43e-0438383MM14611
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

KLK7 MMP9 CTRB1 KLK1

2.42e-04114384MM14571
PathwayREACTOME_UPTAKE_OF_DIETARY_COBALAMINS_INTO_ENTEROCYTES

CUBN CTRB1

3.14e-0410382M45024
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

KLK7 ADAMTS9 MMP9 CTRB1

5.29e-04140384M587
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

KLK7 ADAMTS2 MMP9 CTRB1 KLK1

6.05e-04258385MM14572
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

KLK7 ADAMTS2 ADAMTS9 MMP9 CTRB1

1.19e-03300385M610
PathwayREACTOME_COBALAMIN_CBL_VITAMIN_B12_TRANSPORT_AND_METABOLISM

CUBN CTRB1

1.58e-0322382M27084
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

CCN4 ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 CUBN MMP9 ADAMTSL4

4.16e-137556820637190
Pubmed

Human tissue kallikreins: physiologic roles and applications in cancer.

KLK11 KLK7 KLK14 KLK13 KLK1

1.15e-111356515192120
Pubmed

Differences in Kallikrein-related peptidase mRNA sequences and KLK6 enzyme activity between mouse strains.

KLK11 KLK7 KLK14 KLK13 KLK1

1.78e-111456525666037
Pubmed

Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.

KLK11 KLK7 KLK14 KLK13 KLK1

2.67e-111556515203212
Pubmed

Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005.

KLK11 KLK7 KLK14 KLK13 KLK1

2.67e-111556516800723
Pubmed

A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.

KLK11 KLK7 KLK14 KLK13 KLK1

2.67e-111556516800724
Pubmed

Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.

KLK11 KLK7 KLK14 KLK13 KLK1

3.88e-111656520424135
Pubmed

Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility.

KLK7 KLK14 KLK13 KLK1

1.26e-091056419558318
Pubmed

Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

KLK11 KLK7 KLK13 KLK1

5.96e-091456411054574
Pubmed

Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.

KLK7 KLK14 KLK13 KLK1

6.25e-082456415331780
Pubmed

Organization and evolution of the glandular kallikrein locus in Mus musculus.

KLK14 KLK13 KLK1

4.71e-071056312437987
Pubmed

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.

ADAMTS2 ADAMTS9 ADAMTS20

8.61e-071256325770910
Pubmed

Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients.

CUBN MMP9

2.55e-06256230557881
Pubmed

Immunohistochemical localization and analysis of kallikrein-related peptidase 7 and 11 expression in paired cancer and benign foci in prostate cancer patients.

KLK11 KLK7

2.55e-06256221520985
Pubmed

Parallel overexpression and clinical significance of kallikrein-related peptidases 7 and 14 (KLK7KLK14) in colon cancer.

KLK7 KLK14

2.55e-06256223224034
Pubmed

High TNFRSF12A level associated with MMP-9 overexpression is linked to poor prognosis in breast cancer: Gene set enrichment analysis and validation in large-scale cohorts.

TNFRSF12A MMP9

2.55e-06256230142200
Pubmed

Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.

ADAMTS9 ADAMTS20

2.55e-06256212514189
Pubmed

Understanding the accuracy of statistical haplotype inference with sequence data of known phase.

KLK14 KLK13

2.55e-06256217922479
Pubmed

Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung.

KLK14 KLK13

2.55e-06256218627302
Pubmed

Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis.

KLK14 KLK13

2.55e-06256229546479
Pubmed

Proteolytic action of kallikrein-related peptidase 7 produces unique active matrix metalloproteinase-9 lacking the C-terminal hemopexin domains.

KLK7 MMP9

2.55e-06256221616098
Pubmed

A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression.

ADAMTS9 ADAMTS20

7.63e-06356224753090
Pubmed

Androgens act synergistically to enhance estrogen-induced upregulation of human tissue kallikreins 10, 11, and 14 in breast cancer cells via a membrane bound androgen receptor.

KLK11 KLK14

7.63e-06356219383315
Pubmed

Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis.

MMP9 PTGER3

7.63e-06356219799610
Pubmed

Degradomic Identification of Membrane Type 1-Matrix Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate.

ADAMTS9 ADAMTS20

7.63e-06356237169079
Pubmed

The presence of two types of prorenin converting enzymes in the mouse submandibular gland.

KLK13 KLK1

1.52e-0545621959648
Pubmed

Mouse glandular kallikrein genes: identification and characterization of the genes encoding the epidermal growth factor binding proteins.

KLK13 KLK1

1.52e-0545623322387
Pubmed

Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4.

KLK13 KLK1

1.52e-05456211006094
Pubmed

A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation.

KLK14 KLK1

1.52e-05456217158887
Pubmed

Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22).

KLK13 KLK1

1.52e-0545629507064
Pubmed

Mouse submandibular gland prorenin-converting enzyme is a member of glandular kallikrein family.

KLK13 KLK1

1.52e-0545621918045
Pubmed

Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.

OR1N2 SUSD1 TTLL11

1.56e-053056320583170
Pubmed

Circulating microRNAs and kallikreins before and after radical prostatectomy: are they really prostate cancer markers?

KLK11 KLK13

2.54e-05556224288670
Pubmed

Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus.

KLK13 KLK1

2.54e-0555623036794
Pubmed

ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT in mouse model of Peters plus syndrome.

ADAMTS9 ADAMTS20

2.54e-05556231600785
Pubmed

Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues.

KLK13 KLK1

2.54e-05556212970725
Pubmed

β1-integrin is a cell-autonomous factor mediating the Numb pathway for cardiac progenitor maintenance.

NUMB MESP1

3.80e-05656229653101
Pubmed

Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors.

NUMB MESP1

5.32e-05756224843018
Pubmed

Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation.

ADAMTS9 ADAMTS20

7.09e-05856221041365
Pubmed

The secreted metalloprotease ADAMTS20 is required for melanoblast survival.

ADAMTS9 ADAMTS20

7.09e-05856218454205
Pubmed

Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies.

ADAMTS9 MMP9

7.09e-05856220096780
Pubmed

ADAMTS: a novel family of extracellular matrix proteases.

ADAMTS2 ADAMTS9

1.14e-041056211167130
Pubmed

Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ.

ADAMTS9 ADAMTS20

1.39e-041156233909046
Pubmed

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.

DOK1 NUMB

1.66e-041256212606711
Pubmed

Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation.

ADAMTS9 ADAMTS20

3.41e-041756222183742
Pubmed

ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.

ADAMTS9 ADAMTS20

4.75e-042056219922873
Pubmed

Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.

KLK7 KLK1

5.24e-042156219592578
Pubmed

Epithelial Wnt/βcatenin signalling is essential for epididymal coiling.

CUBN MMP9

5.76e-042256226934381
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ZNF704 FAM53A TTLL11 TNRC6B ADGRG1 NUMB LZTS2 RAPGEF2 SHROOM2

5.81e-04148956928611215
Pubmed

Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.

ADAMTS9 ADAMTS20

6.30e-042356230814516
Pubmed

GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.

ADAMTS9 MMP9

6.30e-042356229567669
Pubmed

Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.

SFTPB TNRC6B

6.30e-042356228811219
Pubmed

ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.

ADAMTS9 ADAMTS20

6.30e-042356226027930
Pubmed

Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly.

ADAMTS2 ADAMTS9

6.87e-042456229791855
Pubmed

Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.

ADAMTS9 ADAMTS20

7.46e-042556229475039
Pubmed

Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice.

SFTPB MMP9

8.07e-042656231562139
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

TNRC6B NUMB LZTS2 RNF43

8.62e-0426356434702444
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

DNAAF2 GTSE1 TNRC6B NUMB SRBD1

9.74e-0447256538943005
Pubmed

The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.

POP1 PWP2 ZBTB9 SRBD1

1.10e-0328156424163370
Pubmed

The DNA sequence and biology of human chromosome 19.

KLK11 ZSCAN5C KLK14 KLK13

1.15e-0328456415057824
Pubmed

Genome-wide association study of periodontal pathogen colonization.

TTLL11 CSMD3

1.15e-033156222699663
Pubmed

Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development.

MESP1 MMP9

1.38e-033456234767447
Pubmed

DNA Damage Regulates Translation through β-TRCP Targeting of CReP.

ZNF704 RAPGEF2

1.46e-033556226091241
Pubmed

High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.

ACSL6 GTSE1 PWP2 TNRC6B

1.52e-0330756437499664
Pubmed

Galnt1 is required for normal heart valve development and cardiac function.

ADAMTS9 ADAMTS20

1.55e-033656225615642
Pubmed

Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983), Seventh International Workshop on Human Gene Mapping.

CTRB1 KLK1

1.55e-03365626690234
InteractionUSP54 interactions

PRR35 TNRC6B CARD10 LZTS2 FAM124B PLEKHN1 RNF43

1.50e-06212547int:USP54
Cytoband9q33.2

OR1N2 TTLL11

1.05e-03395629q33.2
CytobandEnsembl 112 genes in cytogenetic band chr19q13

KLK11 KLK7 ZSCAN5C KLK14 KLK13 KLK1

3.25e-031192566chr19q13
Cytoband22q13.1

TNRC6B CARD10

4.89e-038556222q13.1
CytobandEnsembl 112 genes in cytogenetic band chr14q21

DNAAF2 FANCM

6.32e-0397562chr14q21
GeneFamilyKallikreins

KLK11 KLK7 KLK14 KLK13 KLK1

1.01e-1016365616
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS2 ADAMTS9 ADAMTS20

6.87e-061936350
GeneFamilyADAMTS like

ADAMTSL1 ADAMTSL4

8.04e-057362947
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

SUSD1 CSMD3

5.74e-03573621179
GeneFamilyProteases, serine

KLK11 KLK7

6.98e-0363362738
CoexpressionGSE41176_WT_VS_TAK1_KO_UNSTIM_BCELL_UP

ACSL6 TICAM1 ADGRG1 C10orf95 LTK RAPGEF2 KIF25-AS1

2.14e-07198567M9921
CoexpressionNABA_ECM_REGULATORS

ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 MMP9 ADAMTSL4

1.17e-05238566M3468
CoexpressionNABA_ECM_REGULATORS

ADAMTSL1 ADAMTS2 ADAMTS9 ADAMTS20 MMP9 ADAMTSL4

1.28e-05242566MM17062
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

KLK11 ADAMTSL1 SFTPB KLK14 MESP1 KLK13

1.04e-07180566b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Proximal_secretory_2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

KLK11 KLK14 MESP1 KLK13 VWDE

2.59e-06173565d1e47c87bd4750801f3531f66a56c5dccb4ea64c
ToppCell5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLK11 CCN4 KLK7 ADAMTS20 PTGER3

3.22e-0618156565eaa9bc1022bcf0c5f0f92c07a2cbbf11f9b59c
ToppCell5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(PRG4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLK11 CCN4 KLK7 ADAMTS20 PTGER3

3.22e-06181565eaac7d58117eddfff06b25521efc431c1351d592
ToppCellwk_20-22-Mesenchymal-Mesothelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

KLK11 KLK7 BHLHA9 KLK1 VWDE

3.49e-06184565804f8a41cd6b1361448872bf352bf0a38a0fac66
ToppCellwk_20-22-Mesenchymal-Mesothelial-Late_mesothelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

KLK11 KLK7 BHLHA9 KLK1 VWDE

3.49e-0618456560dd055c2e2e92b838ac649c12e8cccd9c3b1b71
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS9 CARD10 CTRB1 KLK1 ADAMTSL4

3.78e-061875659aa411ae9b5a923378a5daebb8bb2fc2613f2510
ToppCellfacs-Pancreas-Exocrine-3m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS9 CARD10 CTRB1 KLK1 ADAMTSL4

4.41e-06193565c3161a14a40323a58aa202c8a1d6ea0e9c2b9814
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TNFRSF12A PRR35 ADGRG1 PTGER3 KLK1

4.41e-0619356546d5d1f8150ebbc7f1941b96ab184491e5c1210b
ToppCellcellseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KLK11 SFTPB KLK14 MESP1 KLK13

4.52e-061945655402835d6b252276e458001949dd1cb5aa744b0e
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNFRSF12A KLK11 SFTPB KLK14 KLK13

4.52e-06194565855d6acfcf323868ba98b213f06186ad4793d4ed
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNFRSF12A KLK11 SFTPB KLK14 KLK13

4.52e-06194565dc531cf9089f2c956621d70d49a2b8219b4b45c1
ToppCellcellseq-Epithelial-Epithelial_Airway-Secretory/RAS|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KLK11 SFTPB KLK14 MESP1 KLK13

4.52e-061945652c0236a102f7fec6d508afec6137da5b26a65931
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNFRSF12A KLK11 SFTPB KLK14 KLK13

4.52e-0619456529a7770bdbea6081a9ed64a997cd92a1cbf4af58
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNFRSF12A KLK11 SFTPB KLK14 KLK13

4.52e-06194565ca051088f880154ae2fd3f0ab3cef5a8dba8c371
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Club|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

KLK11 SFTPB KLK14 MESP1 KLK13

4.64e-06195565b9e8f405f6d837bb39b615836d3e2df349737c0e
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Club|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

TNFRSF12A KLK11 SFTPB KLK14 KLK13

4.75e-061965654e4c632db73b1340d80bf40a7657cb4821084d3c
ToppCellBiopsy_Control_(H.)-Epithelial-SCGB3A2+_SCGB1A1+|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

KLK11 SFTPB KLK14 MESP1 KLK13

5.00e-06198565a3d4b6e4259ded2193d94d2ff6d48cf67214fc35
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

KLK11 SFTPB KLK14 MESP1 KLK13

5.12e-06199565a8bfc0b93ad9968cf52a25be86995ffe436bd636
ToppCellmedial-2-Epithelial-Mucous|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KLK11 SFTPB KLK14 MESP1 KLK13

5.12e-061995654737250b7ffa7cc19eb6b057d35d78f13b1afe66
ToppCellBiopsy_IPF-Epithelial-SCGB3A2+_SCGB1A1+|Biopsy_IPF / Sample group, Lineage and Cell type

KLK11 SFTPB KLK14 MESP1 KLK13

5.12e-06199565c6150f5fe2ce4466149a4d553acb907034a72efb
ToppCellmedial-Epithelial-Mucous|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KLK11 SFTPB KLK14 MESP1 KLK13

5.12e-061995654385963ab25b5378e7964b984028c25b27e5794e
ToppCellmedial-Epithelial-Mucous-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KLK11 SFTPB KLK14 MESP1 KLK13

5.12e-0619956553198bcf5f2f012a3ed1600d95c0923d6976a099
ToppCellControl-Myeloid-Monocytes,_Macrophages-Mast-cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SAP25 SUSD1 POP1 PTGER3

4.78e-0515956481782e9e370558d61af5e0c760ac9759d69fb725
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 CTRB1 CSMD3 KLK1

5.02e-05161564b9a17f41426bf715f30bf544a6795afaf37a3aa6
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 CTRB1 CSMD3 KLK1

5.02e-05161564f7a89c481f789f624102857be722c95fbeb47595
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF704 FAM53A LTK SRBD1

5.39e-05164564b895674ed2df87db8fbfb30b7e31620945588491
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 SUSD1 PTGER3 KLK1

5.79e-05167564edc5f04584b44f99ff9a62bbe0dab6fc044fb334
ToppCell356C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SAP25 FAM124B PLEKHN1 PTGER3

6.06e-051695640425d2580ed325178f522c0093ff4623de6ce7a8
ToppCell356C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SAP25 FAM124B PLEKHN1 PTGER3

6.06e-05169564fec669968a77060bd77ee8695034e35a642c984f
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK11 SFTPB KLK14 KLK13

6.34e-05171564fd59ac4a39748840b2ee1c930ea475433ff61485
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK11 SFTPB KLK14 KLK13

6.34e-05171564d5960b40ad5b87aaa00c93a6b31cdf41cc4f1375
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK11 SFTPB KLK14 KLK13

6.34e-05171564d382430e5cdd0f2aac4fc093d8fe8d66efb4629b
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK11 SFTPB KLK14 KLK13

6.34e-051715644347e6f62c04ea43299893ad4b79719049009a56
ToppCelldroplet-Lung-nan-21m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SUSD1 ADGRG1 PTGER3 RNF43

6.49e-051725641b133be191252e7053faeacf9547730c3ae28d21
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK11 SFTPB KLK14 KLK13

6.49e-0517256463a91974b12c3f7f0c6bf66c30088d7fc07f5cea
ToppCelldroplet-Lung-nan-21m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SUSD1 ADGRG1 PTGER3 RNF43

6.49e-05172564b3c53fd7e50f36de6a8585ae21d04e17932f262c
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS9 CTRB1 PTGER3 KLK1

6.63e-05173564c62e3ffed55bbb00dcaef6da0aab8446f3f55085
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS9 CTRB1 PTGER3 KLK1

6.63e-05173564f612d4ea9ab8dcde475f4118bca3e49be786e7fa
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF704 SUSD1 PTGER3 RNF43

6.63e-0517356453e97835d7a518c278e7b90a0734eb0095d6aa33
ToppCelldroplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZNF704 ADGRG1 PTGER3 RNF43

6.63e-05173564117163c5cd2b7aaa1c0682c8ac44b4249df4d2f8
ToppCelldroplet-Lung-LUNG-1m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF704 SUSD1 PTGER3 RNF43

6.63e-05173564889a880de5fc19d26b82cfef3067869a28ef17ca
ToppCelldroplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZNF704 ADGRG1 PTGER3 RNF43

6.63e-0517356401df9baeedf30e3a4891738554cdd300394dbb96
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KLK11 ADAMTSL1 SFTPB KLK14

7.25e-05177564779ba86f53650772755b52460be03f18bb204e55
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KLK11 ADAMTSL1 SFTPB KLK14

7.25e-051775640f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TNFRSF12A KLK11 KLK7 ADAMTS9

7.25e-051775640912a291cff32a4ff8a2d7680ed1a1cd867fb90f
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLK11 ADAMTSL1 ADGRG1 PTGER3

7.25e-05177564c1f838e425ebb04482829b1957e3c1347127e6de
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 ADAMTS9 ADGRG1 PTGER3

7.41e-05178564cc0382b0ee1e6c76522e2c86ad1425c45debab5d
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADAMTSL1 ADAMTS9 SHROOM2 VWDE

7.41e-051785648f31b3fac51591f7f2bcb898c07708b3e9f93a16
ToppCellwk_15-18-Mesenchymal-Mesothelial-intermediate_mesothelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KLK11 CCN4 KLK7 LMNTD2

7.57e-05179564b1f085e4c8d65d5cdbfaf2db80343638abb08979
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature3_(11)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CARD10 LTK FAM124B KLK1

7.74e-051805647d4cb0ab9f96088cbc5db3096d884a1e5ce4cb5d
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-Plasma_cell-B_c06-MKI67|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

DNAAF2 KLK11 LTK LZTS2

7.90e-05181564c18e5a3f5d99043fa3cb33e2ac33fa98cd15d3db
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADAMTSL1 ADAMTS9 SHROOM2 VWDE

7.90e-0518156447dce04db3392333eb2f7b9b24c32e6740d2d02f
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADAMTSL1 ADAMTS9 SHROOM2 VWDE

7.90e-0518156419103221c3a5a16b16378348004b2c50caee4f01
ToppCellfacs-Pancreas-Exocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS9 CARD10 CTRB1 KLK1

8.07e-0518256445faefd7cbeac84d2c58650530b902af6ce921f8
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

KLK11 ADGRG1 KLK13 KLK1

8.07e-05182564dc29e8735c3562ce32322351d28f7d9709208ebf
ToppCellE12.5-Epithelial-epithelial_progenitor_cell-epi_progenitor|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TNFRSF12A SFTPB ADGRG1 RNF43

8.25e-05183564031b4ffd95114dc10d2932c67d2cfef139b3fd2e
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNFRSF12A KLK11 KLK7 PLEKHN1

8.25e-0518356403649492c37f9b274a1caf3e2132ce2915cf1df5
ToppCellControl-Epithelial-Goblet|World / Disease state, Lineage and Cell class

KLK11 SFTPB KLK14 KLK13

8.60e-051855649a793e6016295a63820e9d7563f195494ac692e7
ToppCellPND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFTPB KLK14 ADGRG1 KLK13

8.60e-05185564fd51fef8c69e34c72017d8371ab0a0d7be5701f2
ToppCellPND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFTPB KLK14 ADGRG1 KLK13

8.60e-05185564bea26e369ae91006052b973cd89b4c49afa9e553
ToppCellControl-Epithelial-Club|Epithelial / Disease state, Lineage and Cell class

KLK11 ADAMTSL1 SFTPB KLK14

8.60e-051855646814b3c94c7558443c038a227b5c8563d2cfeac4
ToppCellCOPD-Epithelial-Goblet|World / Disease state, Lineage and Cell class

KLK11 KLK7 SFTPB KLK14

8.78e-05186564d75fe7640a4b2c450c9759a1b3c3ef2a087f0092
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK11 SFTPB KLK14 KLK13

8.78e-0518656455fe25f4d0f2bc0fd4802a0a375169f2c41472fc
ToppCellAdult-Epithelial-club_cell-D231|Adult / Lineage, Cell type, age group and donor

KLK11 SFTPB CUBN KLK13

8.96e-05187564ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCellCOVID-19-kidney-CD-IC-B|kidney / Disease (COVID-19 only), tissue and cell type

ADAMTSL1 SUSD1 CSMD3 PTGER3

8.96e-05187564ce05b89860573fe0356102e2998d1ef6d1968034
ToppCellNS-critical-d_07-13-Epithelial-IRC-IFNG_responsive_cell|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TNFRSF12A SFTPB CTRB1 PTGER3

9.15e-051885646ee2e7fa80f48e4a7f3321b0776a4f697469bc61
ToppCelldroplet-Lung-nan-18m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFTPB KLK14 MESP1 KLK13

9.34e-05189564ca657353f2b649530809c0bc057e448adc511ec1
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFRSF12A KLK11 CARD10 PHF13

9.34e-051895641cfc1fe27c4b57b4e52700fa8f679ce172cee5a9
ToppCelldroplet-Lung-nan-18m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFTPB KLK14 MESP1 KLK13

9.34e-05189564e5325f1c7430b574947f8ee67e425455b60dc518
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

ADAMTSL1 ADAMTS9 NUMB SHROOM2

9.34e-05189564c81787a8c662db5d7814c583dd64562857629e81
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTRB1 PTGER3 KLK1

9.42e-05705635720505ef03d65c73028616c808420e282823bde
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNFRSF12A KLK7 ADAMTS9 PTGER3

9.53e-05190564f39ce1678fc375eb2a3af781ddb772b0f12c5744
ToppCellClub|World / shred by cell class for parenchyma

KLK11 SFTPB KLK14 KLK13

9.53e-051905641974d559d7fee6cb68065b18af8bd38b64910622
ToppCellIPF-Epithelial-Goblet|World / Disease state, Lineage and Cell class

KLK11 SFTPB KLK14 KLK13

9.53e-05190564c29dabf0826663b9d6df51a7af9b76592090e44c
ToppCell(7)_Epithelial-G_(Club-Clara_cells)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

KLK11 SFTPB KLK14 KLK13

9.53e-05190564593fd1451038b155826a48de4caa38f44406d0b9
ToppCellIPF-Epithelial-Goblet|Epithelial / Disease state, Lineage and Cell class

KLK11 SFTPB KLK14 MESP1

9.73e-05191564267e1192aaec468c1a59eb24848b37e0e18cbc44
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADAMTS9 CARD10 MESP1 SHROOM2

9.92e-051925648899d81306770adda893b5e146df1253971754c5
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Club|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KLK11 SFTPB KLK14 KLK13

9.92e-05192564044c7ae56da17cacf2705efa8ac2c8aeba6cfeee
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADAMTS9 CARD10 MESP1 SHROOM2

9.92e-051925645fda9a465c9f77c7fa1a3ea07a2b0374bbc23b2a
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KLK11 C10orf95 RAPGEF2 PHF13

1.01e-041935640ef076417ffe2dd1cbc2c3d1e35c7f8522af143b
ToppCellNS-critical-d_07-13-Epithelial-Squamous|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KLK11 KLK7 TICAM1 KLK13

1.03e-0419456453a34843d529ef395deb27086f71f7049a087bab
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical|TCGA-Thryoid / Sample_Type by Project: Shred V9

TNFRSF12A KLK7 SFTPB PLEKHN1

1.03e-04194564b46c54802b8d1e0a0a17f9ed8e82eaf5e7f4849d
ToppCellnormal_Lung-Epithelial_cells-Club|normal_Lung / Location, Cell class and cell subclass

KLK11 SFTPB KLK14 KLK13

1.05e-04195564b46544ad5af04f4dbc2643637caa3d2d50d922ae
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK11 SFTPB KLK14 KLK13

1.07e-041965641b3a191749cf143d35f7f73cf0e239535ece0ca7
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK11 SFTPB KLK14 KLK13

1.07e-04196564982ed511edb3f802d8e6a46cd8e97f6482f49437
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK11 SFTPB KLK14 KLK13

1.07e-041965647e52c212e2b910f2f25fdbedc92fe1c9d3e2602f
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK11 SFTPB KLK14 KLK13

1.07e-04196564cdc89eb6a9c3811dc4fd15e73f596299a61326ee
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK11 SFTPB KLK14 KLK13

1.07e-0419656450436ddc61e4ab8df055a527e7514aaaaf6e90ee
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TNFRSF12A PRR35 PTGER3 KLK1

1.07e-041965646ee8dcc5cd643747e20d23b9556c17f7c102b19c
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK11 SFTPB KLK14 KLK13

1.07e-041965640d83501e580de523aac073709395ed7b889e0bb2
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK11 SFTPB KLK14 KLK13

1.07e-04196564b74d9560acf87827947a04489095b60d466d6637
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLK11 SFTPB KLK14 KLK13

1.07e-0419656414aa7a0cb905983ca98e05f8fa9a1c94f2031333
ToppCellNS-control-d_0-4-Epithelial-Squamous|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KLK11 KLK7 TICAM1 KLK13

1.10e-04197564ab965a0ba87efd3329d24a1ec123985f46fc17c0
ToppCellParenchymal-10x5prime-Stromal-Mesofibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KLK11 CCN4 KLK7 PTGER3

1.10e-0419756488a86286b9c3ea3b076d7464faec42d0392ee7f8
ToppCellParenchymal-10x5prime-Stromal-Mesofibroblastic-Mesothelia|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KLK11 CCN4 KLK7 PTGER3

1.10e-041975642773d2eb5f232a7e49da116efffcb6bf5eb90810
ToppCellcritical-Epithelial-Squamous|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KLK11 KLK7 TICAM1 KLK13

1.10e-04197564eccc80d6ab79c46b10108de1cff3abeacfc105cd
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic-leukocyte|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KLK11 KLK7 TNRC6B KLK13

1.10e-04197564e621d4f9d4ba5e3ef17d2b477e5e14ea0251147e
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KLK11 SFTPB KLK14 KLK13

1.12e-041985645d57acbe0d245f8bd217eeea07af060092898fbd
ToppCellmedial-2-Epithelial-Club|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KLK11 SFTPB KLK14 KLK13

1.12e-041985647f59d949190c10af13cbd13f81a795483deb9d14
Drugchlorazanil

KLK7 KLK14 KLK13 KLK1

5.84e-0816564CID000010374
DrugCP094

KLK11 KLK7 KLK14 CUBN MMP9 KLK13 KLK1

1.59e-07165567CID000086322
DrugB3852

KLK7 KLK14 KLK13 KLK1

2.32e-0722564CID003081658
DrugLeupeptin hydrochloride

KLK11 KLK7 KLK14 CUBN MMP9 CTRB1 KLK13 KLK1

3.62e-07276568CID000003910
Drugepanolol

KLK7 KLK14 KLK13 KLK1

3.99e-0725564CID000072014
DrugCHCl

KLK7 KLK14 CTRB1 KLK13 KLK1

5.53e-0765565CID006432229
DrugSA446

KLK7 KLK14 KLK13 KLK1

9.83e-0731564CID000071244
DrugEACA

KLK11 KLK7 KLK14 CTRB1 KLK13 KLK1

1.90e-06151566CID000000564
DrugTLCK

KLK7 KLK14 MMP9 CTRB1 KLK13 KLK1

2.48e-06158566CID000004427
Drugcamostate

KLK7 KLK14 CTRB1 KLK13 KLK1

2.51e-0688565CID000002536
DrugS2266

KLK14 CTRB1 KLK13 KLK1

2.81e-0640564CID000122333
Drugmeclofenamate

KLK7 KLK14 PTGER3 KLK13 KLK1

3.48e-0694565CID000004036
Drugphenylmethylsulfonyl fluoride

KLK11 KLK7 KLK14 MMP9 CTRB1 KLK13 KLK1

3.63e-06263567CID000004784
Drugatenolol

KLK7 KLK14 FANCM KLK13 KLK1

1.25e-05122565CID000002249
DrugN-benzoyl-L-arginine

KLK14 CTRB1 KLK13 KLK1

1.26e-0558564CID000097369
DrugProresid

KLK7 ADAMTS2 KLK14 CTRB1 KLK13

1.97e-05134565CID000015184
Drugbenzamidine

KLK11 KLK14 CTRB1 KLK13 KLK1

3.07e-05147565CID000002332
DrugAC1NRA23

KLK11 CUBN CTRB1 KLK1

3.15e-0573564CID005287657
DrugAprotinin

CTRB1 KLK1

3.55e-054562DB06692
DrugAC1Q6PMP

KLK11 KLK7 MMP9 CTRB1 KLK1

5.97e-05169565CID000103535
DrugDB04780

KLK7 KLK14 KLK13 KLK1 ADAMTSL4

6.14e-05170565CID005459389
DrugFFRck

KLK14 KLK13 KLK1

7.99e-0534563CID000126484
Drugamsonine

KLK7 KLK14 PTGER3 KLK13 KLK1

8.26e-05181565CID000002866
DrugAC1NRA8H

KLK7 KLK14 KLK13 KLK1

8.85e-0595564CID005287756
DrugMEK1/2 inhibitor

DOK1 KLK11 CCN4 KLK14 KLK13

1.12e-04193565CID009549284
DrugAmiodarone hydrochloride [19774-82-4]; Up 200; 5.8uM; MCF7; HT_HG-U133A

KLK7 C10orf95 PTGER3 KLK13 ADAMTSL4

1.23e-041975655618_UP
DrugAAPCK

CTRB1 KLK1

1.24e-047562CID000128055
DrugEs 8891

CTRB1 KLK1

1.24e-047562CID000195623
DrugGM3 lactone

KLK1 HCP5

1.24e-047562CID006438841
DrugClenbuterol hydrochloride [21898-19-1]; Up 200; 12.8uM; MCF7; HT_HG-U133A

ADAMTS20 C10orf95 LTK PTGER3 KLK13

1.29e-041995655266_UP
DrugDesipramine hydrochloride [58-28-6]; Down 200; 13.2uM; PC3; HT_HG-U133A

SFTPB GTSE1 CARD10 MMP9 PTGER3

1.29e-041995656693_DN
Drugoxamic acid sodium salt; Down 200; 10000uM; MCF7; HG-U133A

DNAAF2 LTK PTGER3 KLK13 ADAMTSL4

1.29e-04199565439_DN
DrugN-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Up 200; 25.2uM; PC3; HT_HG-U133A

KLK7 SFTPB TICAM1 ADGRG1 ADAMTSL4

1.29e-041995654311_UP
Drugdiisopropylfluorophosphate

KLK11 KLK7 KLK14 CTRB1 KLK13 KLK1

1.34e-04321566CID000005936
DrugT-kinin

KLK14 KLK13 KLK1

1.41e-0441563CID000123643
Drugnimesulide

KLK7 KLK14 KLK13 KLK1

1.79e-04114564CID000004495
DrugEtretinate-d3

KLK11 KLK14 KLK13

1.86e-0445563CID000003312
DrugLMWH

KLK7 SFTPB KLK14 MMP9 CTRB1 KLK13 KLK1 ADAMTSL4

2.05e-04663568CID000000772
Drug5-amino-2-nitrobenzoic acid

CTRB1 KLK1

2.12e-049562CID000083298
Diseasekallikrein-11 measurement

KLK11 KLK7 KLK13

4.06e-079513EFO_0010573
Diseaselevel of kallikrein-10 in blood serum

KLK11 KLK7

8.78e-063512OBA_2042126
Diseasekallikrein-13 measurement

KLK14 KLK13

2.92e-055512EFO_0020512
Diseasebacterial pneumonia (is_marker_for)

SFTPB MMP9

1.05e-049512DOID:874 (is_marker_for)
Diseaseinterstitial lung disease (is_implicated_in)

SFTPB MMP9

1.31e-0410512DOID:3082 (is_implicated_in)
Diseasekallikrein-12 measurement

KLK11 KLK13

2.26e-0413512EFO_0008194
Diseasemembranous glomerulonephritis (biomarker_via_orthology)

MMP9 PTGER3

2.63e-0414512DOID:10976 (biomarker_via_orthology)
DiseaseMyocardial Infarction

TNFRSF12A MMP9 KLK1

6.02e-0495513C0027051
Diseaselung disease (is_marker_for)

SFTPB MMP9

6.62e-0422512DOID:850 (is_marker_for)
Diseasemyocardial infarction (is_implicated_in)

MESP1 MMP9 KLK1

6.79e-0499513DOID:5844 (is_implicated_in)
Diseaseprostate carcinoma

ADAMTSL1 TNRC6B ADGRG1 SHROOM2 ADAMTSL4 RNF43 HCP5

8.13e-04891517EFO_0001663
Diseaseinterstitial lung disease (is_marker_for)

SFTPB MMP9

8.57e-0425512DOID:3082 (is_marker_for)
Diseaseadult respiratory distress syndrome (is_marker_for)

SFTPB MMP9

9.27e-0426512DOID:11394 (is_marker_for)
Diseaseresponse to angiotensin-converting enzyme inhibitor, response to angiotensin receptor blocker, angioedema

ADAMTSL1 VWDE

9.27e-0426512EFO_0005325, EFO_0005532, EFO_0010735
Diseaseobstructive sleep apnea (is_marker_for)

SFTPB MMP9

1.15e-0329512DOID:0050848 (is_marker_for)
Diseasefear of minor pain measurement

RAPGEF2 FAM124B

1.32e-0331512EFO_0008340
Diseaseprimary dental caries

SUSD1 CUBN

1.59e-0334512EFO_0600095

Protein segments in the cluster

PeptideGeneStartEntry
VWVECGSSRGCPSSS

CARD10

1016

Q9BWT7
TGPWGECSSECGSGT

ADAMTSL4

916

Q6UY14
STPWSPCSRSCQGGT

ADAMTSL4

976

Q6UY14
WSGSQPHCSGDATGT

CSMD3

3041

Q7Z407
SGGSWRRCPGASSAG

BHLHA9

201

Q7RTU4
SPWSPCSTSCGLGVS

CCN4

221

O95388
GPWGSCSSSCSGGLQ

ADAMTS20

1311

P59510
AWSPFGSCSRTCGTG

ADAMTS2

566

O95450
SAEDPTGTWTVSGPC

NFE4

121

Q86UQ8
LTPGTTCRVSGWGTT

KLK13

151

Q9UKR3
TDGRSDGLPWCSTTA

MMP9

246

P14780
SGWASGCPSGTLSDS

LZTS2

206

Q9BRK4
EPEVGSTCLASGWGS

KLK1

146

P06870
ACASPGTSCRVSGWG

KLK14

151

Q9P0G3
GTSCRVSGWGTISSP

KLK14

156

Q9P0G3
GSPCLSSRSLAWGSS

DNAAF2

466

Q9NVR5
TWGSSISRSSGTPGC

FANCM

11

Q8IYD8
EATPWTACSSSCGGG

ADAMTSL1

381

Q8N6G6
VTSWSACTRSCGGGV

ADAMTSL1

1551

Q8N6G6
SPGTEGSWLFSTCGA

LTK

61

P29376
TWCFISTGRGGNGTS

PTGER3

206

P43115
GTTCTVSGWGTTTSP

KLK7

141

P49862
GTSCLISGWGSTSSP

KLK11

171

Q9UBX7
EWGSLPCLNTSSSGG

LMNTD2

266

Q8IXW0
TGHCRGGSVSVTWSS

KIF25-AS1

111

Q9Y6Z4
SSSGPVWSGASSACT

GTSE1

311

Q9NYZ3
VWSGASSACTSPAVG

GTSE1

316

Q9NYZ3
PSLCDSSHASSWGSG

HCP5

71

Q6MZN7
SITCAWRGGDSSSHP

HCP5

86

Q6MZN7
PGSGWGTCVATRSSQ

PRR35

541

P0CG20
SAWCGPSSEDSRGGR

POP1

816

Q99575
EIIWTSSPSGCGGTL

CUBN

3501

O60494
STGPWSSCSVSCGRG

ADAMTS9

1446

Q9P2N4
SGSPTSDRCAGTSWK

FAM124B

301

Q9H5Z6
GASGSWDCGLSRVGT

DOK1

456

Q99704
SSPGHWSSAGCETVR

ADGRG1

356

Q9Y653
VSWGSDTCSTSSPGV

CTRB1

231

P17538
SSPGGRWKAFSTCGS

OR1N2

246

Q8NGR9
TCSGTEWGQSSGAAS

NUMB

411

P49757
WGANCSSGASFSGRT

SAP25

21

Q8TEE9
GSLSSGGQTSWDSGC

PLEKHN1

341

Q494U1
TLCGPGTAAWTTSSL

SFTPB

16

P07988
RGEWPDSGSSCSSAP

RNF43

256

Q68DV7
ASPFTSTSGCPSWSG

SHROOM2

131

Q13796
DCGRSLVSSPDSWGS

MESP1

31

Q9BRJ9
SSETPSTSTVWGGTC

SRBD1

151

Q8N5C6
GCTFTTPGDWTSGHV

ACSL6

466

Q9UKU0
SSPTTAWSGACGAGP

C10orf95

221

Q9H7T3
AADSGRGSWTSCSSG

RAPGEF2

1241

Q9Y4G8
DPCSGWDSDTPSSGS

PHF13

166

Q86YI8
VGPSTCSCPSGWSGK

VWDE

1501

Q8N2E2
TRGSGCSGGSLVADW

TTLL11

56

Q8NHH1
SPTGRCWAATTTEGL

PWP2

711

Q15269
SDWSQGCSLRSTGSP

TICAM1

186

Q8IUC6
DTVSSCTGLGTWESP

SUSD1

216

Q6UWL2
LSGSWKEGGCVPSST

ZNF704

111

Q6ZNC4
STTSSTGGWCIRSSP

ZBTB9

161

Q96C00
SVSCWTPCPVTGTGG

FP248

91

Q71RG6
PGTAPCSRGSSWSAD

TNFRSF12A

31

Q9NP84
TSSWSLGESCNSPGS

ZSCAN5C

6

A6NGD5
PCWGRSSSSTGSEVG

TNRC6B

556

Q9UPQ9
DSSEGSAGSGPLWCS

FAM53A

196

Q6NSI3