Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	RGPD4 RANBP2 ANAPC11 RFPL4B MED24 RGPD3 DZIP3 ASB4 MED23 RNF111	3.69e-05	398	102	10	GO:0061659
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	RGPD4 RANBP2 ANAPC11 SKP1 RFPL4B MED24 RGPD3 DZIP3 ASB4 MED23 RNF111	6.15e-05	512	102	11	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	RGPD4 RANBP2 ANAPC11 SKP1 RFPL4B MED24 RGPD3 DZIP3 ASB4 MED23 RNF111	8.65e-05	532	102	11	GO:0016755
GeneOntologyMolecularFunction	SUMO ligase activity	RGPD4 RANBP2 RGPD3	1.38e-04	20	102	3	GO:0061665
GeneOntologyMolecularFunction	acyltransferase activity	RGPD4 GLYAT RANBP2 KAT6A ANAPC11 SKP1 RFPL4B MED24 RGPD3 DZIP3 ASB4 MED23 RNF111	1.59e-04	775	102	13	GO:0016746
GeneOntologyBiologicalProcess	positive regulation of glucokinase activity	RGPD4 RANBP2 RGPD3	9.94e-06	9	103	3	GO:0033133
GeneOntologyBiologicalProcess	positive regulation of hexokinase activity	RGPD4 RANBP2 RGPD3	1.41e-05	10	103	3	GO:1903301
GeneOntologyBiologicalProcess	regulation of glucokinase activity	RGPD4 RANBP2 RGPD3	3.34e-05	13	103	3	GO:0033131
GeneOntologyBiologicalProcess	regulation of hexokinase activity	RGPD4 RANBP2 RGPD3	4.23e-05	14	103	3	GO:1903299
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD4 RANBP2 RGPD3	6.21e-06	8	102	3	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD4 RANBP2 RGPD3	1.32e-05	10	102	3	GO:0044614
GeneOntologyCellularComponent	annulate lamellae	RGPD4 RANBP2 RGPD3	3.95e-05	14	102	3	GO:0005642
GeneOntologyCellularComponent	nuclear pore nuclear basket	RGPD4 RANBP2 RGPD3	8.73e-05	18	102	3	GO:0044615
GeneOntologyCellularComponent	nuclear inclusion body	RGPD4 RANBP2 RGPD3	1.21e-04	20	102	3	GO:0042405
GeneOntologyCellularComponent	nuclear pore	RGPD4 RANBP2 RGPD3 SENP2 NUP188	1.37e-04	101	102	5	GO:0005643
GeneOntologyCellularComponent	SUMO ligase complex	RGPD4 RANBP2 RGPD3	1.41e-04	21	102	3	GO:0106068
GeneOntologyCellularComponent	cell cortex	ARHGAP32 MYO5B OOEP SPTBN5 DST SCNN1A CTBP1 EXOC2	4.69e-04	371	102	8	GO:0005938
GeneOntologyCellularComponent	nuclear protein-containing complex	RGPD4 KDM3A RANBP2 ATR TBL1Y ANAPC11 INTS3 SKP1 WDR3 MED24 RGPD3 SENP2 NUP188 ZCCHC7 MED23 KDM6A	1.01e-03	1377	102	16	GO:0140513
GeneOntologyCellularComponent	apical cortex	MYO5B SPTBN5	1.03e-03	10	102	2	GO:0045179
GeneOntologyCellularComponent	hemidesmosome	DST PLEC	1.26e-03	11	102	2	GO:0030056
GeneOntologyCellularComponent	chaperonin-containing T-complex	CCT8L2 CCT8L1P	1.26e-03	11	102	2	GO:0005832
GeneOntologyCellularComponent	cell cortex region	MYO5B SPTBN5 CTBP1	1.38e-03	45	102	3	GO:0099738
GeneOntologyCellularComponent	nuclear envelope	RGPD4 RANBP2 ATR APP WDR3 DST RGPD3 SENP2 NUP188	1.68e-03	560	102	9	GO:0005635
MousePheno	abnormal eye physiology	RGPD4 KDM3A RANBP2 ZBTB43 TUBGCP4 DST ALMS1 AARS2 CEP78 TYW1B RGPD3 FBXO41 PLG	2.39e-05	606	77	13	MP:0005253
Domain	Ran_BP1	RGPD4 RANBP2 RGPD3	3.26e-05	12	101	3	PF00638
Domain	RANBD1	RGPD4 RANBP2 RGPD3	3.26e-05	12	101	3	PS50196
Domain	RanBD	RGPD4 RANBP2 RGPD3	4.22e-05	13	101	3	SM00160
Domain	Ran_bind_dom	RGPD4 RANBP2 RGPD3	4.22e-05	13	101	3	IPR000156
Domain	DEK_C	SSH1 SSH2	1.73e-04	4	101	2	PF08766
Domain	DEK_C	SSH1 SSH2	1.73e-04	4	101	2	IPR014876
Domain	ACTININ_2	SPTBN5 DST PLEC	2.51e-04	23	101	3	PS00020
Domain	ACTININ_1	SPTBN5 DST PLEC	2.51e-04	23	101	3	PS00019
Domain	Actinin_actin-bd_CS	SPTBN5 DST PLEC	2.51e-04	23	101	3	IPR001589
Domain	-	DST PLEC	4.28e-04	6	101	2	3.90.1290.10
Domain	Spectrin_repeat	SPTBN5 DST PLEC	5.06e-04	29	101	3	IPR002017
Domain	Plectin	DST PLEC	5.97e-04	7	101	2	PF00681
Domain	Rab_bind	RGPD4 RGPD3	5.97e-04	7	101	2	PF16704
Domain	Plectin_repeat	DST PLEC	5.97e-04	7	101	2	IPR001101
Domain	GCC2_Rab_bind	RGPD4 RGPD3	5.97e-04	7	101	2	IPR032023
Domain	PLEC	DST PLEC	5.97e-04	7	101	2	SM00250
Domain	TPR	RGPD4 RANBP2 CNOT10 RGPD3 KDM6A	6.78e-04	129	101	5	SM00028
Domain	SPEC	SPTBN5 DST PLEC	6.79e-04	32	101	3	SM00150
Domain	Spectrin/alpha-actinin	SPTBN5 DST PLEC	6.79e-04	32	101	3	IPR018159
Domain	TPR_repeat	RGPD4 RANBP2 CNOT10 RGPD3 KDM6A	7.79e-04	133	101	5	IPR019734
Domain	-	RGPD4 RANBP2 ATR CNOT10 RGPD3 KDM6A	9.12e-04	207	101	6	1.25.40.10
Domain	-	RGPD4 RGPD3	1.27e-03	10	101	2	1.10.220.60
Domain	Grip	RGPD4 RGPD3	1.54e-03	11	101	2	SM00755
Domain	GRIP	RGPD4 RGPD3	1.54e-03	11	101	2	PF01465
Domain	TPR-like_helical_dom	RGPD4 RANBP2 ATR CNOT10 RGPD3 KDM6A	1.67e-03	233	101	6	IPR011990
Domain	-	FBXL12 ADGRA2 CEP78 PXDNL FSHR FBXO41 ADGRA3	1.80e-03	321	101	7	3.80.10.10
Domain	GRIP_dom	RGPD4 RGPD3	1.84e-03	12	101	2	IPR000237
Domain	GRIP	RGPD4 RGPD3	1.84e-03	12	101	2	PS50913
Domain	L_dom-like	FBXL12 ADGRA2 CEP78 PXDNL FSHR FBXO41 ADGRA3	2.03e-03	328	101	7	IPR032675
Domain	-	EFNA3 HEPHL1	2.53e-03	14	101	2	2.60.40.420
Domain	-	ROBO4 ADGRA2 CRLF2 CD84 PXDNL COL14A1 EXOC2 CAMTA1 IL6R ADGRA3	3.13e-03	663	101	10	2.60.40.10
Domain	Ig-like_fold	ROBO4 ADGRA2 CRLF2 CD84 PXDNL COL14A1 EXOC2 CAMTA1 IL6R ADGRA3	4.87e-03	706	101	10	IPR013783
Domain	Apc4_WD40_dom	COPA WDR3	5.16e-03	20	101	2	IPR024977
Domain	ANAPC4_WD40	COPA WDR3	5.16e-03	20	101	2	PF12894
Domain	CH	SPTBN5 DST PLEC	5.26e-03	65	101	3	SM00033
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	RGPD4 RANBP2 RGPD3 NUP188	7.90e-05	40	81	4	MM14945
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS	RGPD4 RANBP2 RGPD3 NUP188	8.71e-05	41	81	4	MM15200
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	RGPD4 RANBP2 RGPD3 NUP188	9.59e-05	42	81	4	MM15039
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	RGPD4 RANBP2 RGPD3 NUP188	1.05e-04	43	81	4	MM14609
Pathway	BIOCARTA_RANBP2_PATHWAY	RGPD4 RANBP2 RGPD3	1.40e-04	18	81	3	MM1549
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	RGPD4 RANBP2 RGPD3 NUP188	1.50e-04	47	81	4	MM14939
Pathway	REACTOME_MITOTIC_PROMETAPHASE	RGPD4 KNTC1 RANBP2 TUBGCP4 ALMS1 CEP78 RGPD3	1.59e-04	202	81	7	MM15362
Pathway	REACTOME_GENE_SILENCING_BY_RNA	RGPD4 RANBP2 RGPD3 NUP188	1.76e-04	49	81	4	MM14837
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	RGPD4 RANBP2 RGPD3 NUP188	1.91e-04	50	81	4	MM14610
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	RGPD4 RANBP2 RGPD3 NUP188	2.06e-04	51	81	4	MM15151
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	RGPD4 RANBP2 RGPD3 NUP188	2.76e-04	55	81	4	MM14917
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	FBXL12 ANAPC11 SKP1 KLHL11 DZIP3 FBXO41 ASB4 RNF111	3.13e-04	299	81	8	MM15711
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	RGPD4 RANBP2 RGPD3 NUP188	3.39e-04	58	81	4	MM15149
Pathway	REACTOME_SNRNP_ASSEMBLY	RGPD4 RANBP2 RGPD3 NUP188	3.39e-04	58	81	4	MM14736
Pathway	REACTOME_M_PHASE	RGPD4 KNTC1 RANBP2 ANAPC11 TUBGCP4 ALMS1 CEP78 RGPD3 NUP188	3.68e-04	387	81	9	MM15364
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	FBXL12 ANAPC11 SKP1 KLHL11 DZIP3 FBXO41 ASB4 RNF111	3.82e-04	308	81	8	M1070
Pathway	REACTOME_SUMOYLATION	RGPD4 RANBP2 RGPD3 CTBP1 SENP2 NUP188	4.19e-04	169	81	6	MM14919
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	RGPD4 RANBP2 RGPD3 NUP188	5.25e-04	65	81	4	MM15147
Pathway	REACTOME_MITOTIC_SPINDLE_CHECKPOINT	RGPD4 KNTC1 RANBP2 ANAPC11 RGPD3	5.60e-04	117	81	5	MM15387
Pathway	REACTOME_CELL_CYCLE	FOXM1 RGPD4 KNTC1 RANBP2 ANAPC11 TUBGCP4 SKP1 ALMS1 CEP78 RGPD3 NUP188	6.38e-04	603	81	11	MM14635
Pathway	REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION	FBXL12 ANAPC11 SKP1 KLHL11 DZIP3 FBXO41 ASB4 RNF111	7.77e-04	343	81	8	MM15712
Pathway	REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE	RGPD4 RANBP2 RGPD3 NUP188	8.15e-04	73	81	4	MM14948
Pathway	REACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY	DST PLEC	1.14e-03	9	81	2	MM15117
Pubmed	Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.	RGPD4 RANBP2 RGPD3 SENP2	5.29e-07	22	104	4	27717094
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FOXM1 KDM3A RANBP2 ATR COPA ZNF507 INTS3 VIRMA MED24 SSH1 EXOC2 PLEC KDM6A	5.66e-07	774	104	13	15302935
Pubmed	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.	RGPD4 KDM3A RANBP2 DNER GALNT13 LIMS1 ALMS1 RGPD3 FBXO41 REV1	8.95e-07	442	104	10	15815621
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	9037092
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	11353387
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	38838144
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	7559465
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	17372272
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	38657106
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	21205196
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	18949001
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	25187515
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	8603673
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	26632511
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	24403063
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	23818861
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	23536549
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	22821000
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD4 RANBP2 RGPD3	9.01e-07	7	104	3	20682751
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD4 RANBP2 RGPD3	1.44e-06	8	104	3	21670213
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RGPD4 RANBP2 RGPD3	1.44e-06	8	104	3	27412403
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RGPD4 RANBP2 RGPD3	1.44e-06	8	104	3	21310149
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD4 RANBP2 RGPD3	1.44e-06	8	104	3	22262462
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD4 RANBP2 RGPD3	1.44e-06	8	104	3	28745977
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	RGPD4 RANBP2 ATR INTS3 VIRMA WDR3 LIMS1 RGPD3 PLEC	1.79e-06	370	104	9	22922362
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RGPD4 RANBP2 RGPD3	2.15e-06	9	104	3	18394993
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RGPD4 RANBP2 RGPD3	2.15e-06	9	104	3	28100513
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RGPD4 RANBP2 RGPD3	2.15e-06	9	104	3	17887960
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RGPD4 RANBP2 RGPD3	2.15e-06	9	104	3	11553612
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RGPD4 RANBP2 RGPD3	2.15e-06	9	104	3	10601307
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RGPD4 RANBP2 RGPD3	2.15e-06	9	104	3	9733766
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RGPD4 RANBP2 RGPD3	2.15e-06	9	104	3	28877029
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	ARHGAP32 MYO5B DST ALMS1 AARS2 MED23	2.73e-06	130	104	6	12421765
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RGPD4 RANBP2 RGPD3	3.07e-06	10	104	3	27160050
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD4 RANBP2 RGPD3	3.07e-06	10	104	3	16332688
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RGPD4 RANBP2 RGPD3	3.07e-06	10	104	3	8857542
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RGPD4 RANBP2 RGPD3	3.07e-06	10	104	3	21859863
Pubmed	An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.	ARHGAP32 PDLIM7 ZBTB43 FBXL12 TUBGCP4 RUNX1T1 SKP1 LIMS1 DZIP3 RNF111	3.44e-06	514	104	10	29892012
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD4 RANBP2 RGPD3	4.21e-06	11	104	3	17069463
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RGPD4 RANBP2 RGPD3	4.21e-06	11	104	3	35771867
Pubmed	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.	RGPD4 RANBP2 RGPD3	4.21e-06	11	104	3	34110283
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	RGPD4 RANBP2 RGPD3 NUP188	5.15e-06	38	104	4	12791264
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RGPD4 ARHGAP32 RANBP2 TBL1Y SKP1 VIRMA DST SSH1 RGPD3 DZIP3 FBXO41 CTBP1 SSH2	6.21e-06	963	104	13	28671696
Pubmed	Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.	RGPD4 RANBP2 RGPD3	7.27e-06	13	104	3	31427429
Pubmed	N6-methyladenosine (m6A) writer KIAA1429 accelerates gastric cancer oxaliplatin chemoresistance by targeting FOXM1.	FOXM1 VIRMA	8.86e-06	2	104	2	36326914
Pubmed	Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit.	ABCC9 MED23	8.86e-06	2	104	2	11934987
Pubmed	Urinary plasmin activates collecting duct ENaC current in preeclampsia.	SCNN1A PLG	8.86e-06	2	104	2	22987920
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	RGPD4 RANBP2 RGPD3	1.15e-05	15	104	3	14697343
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ARHGAP32 RANBP2 COPA MYO5B PDLIM7 FLVCR1 FBXL12 APP SKP1 SSH1 SENP2 SSH2 KDM6A	1.54e-05	1049	104	13	27880917
Pubmed	BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin.	DST PLEC	2.65e-05	3	104	2	19932097
Pubmed	Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.	SSH1 SSH2	2.65e-05	3	104	2	14531860
Pubmed	The interaction between the adaptor protein APS and Enigma is involved in actin organisation.	PDLIM7 SH2B2	2.65e-05	3	104	2	15946664
Pubmed	Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.	ADGRA2 ADGRA3	2.65e-05	3	104	2	15021905
Pubmed	An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation.	FBXL12 SKP1	2.65e-05	3	104	2	23324393
Pubmed	F-box protein FBXO41 suppresses breast cancer growth by inducing autophagic cell death through facilitating proteasomal degradation of oncogene SKP2.	SKP1 FBXO41	2.65e-05	3	104	2	35598880
Pubmed	KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A modification to promote aerobic glycolysis and tumorigenesis in multiple myeloma.	FOXM1 VIRMA	2.65e-05	3	104	2	39060874
Pubmed	T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.	KDM6A IL6R	2.65e-05	3	104	2	26431949
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RGPD4 RANBP2 ZNF507 DST ALMS1 RGPD3 CTBP1 PLEC	3.84e-05	418	104	8	34709266
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	COPA CNOT10 TUBGCP4 WDR3 MED24 AARS2 COG6 EXOC2 MED23	4.83e-05	560	104	9	35241646
Pubmed	Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's disease.	APP PLG	5.29e-05	4	104	2	20547128
Pubmed	Fe65 Ser228 is phosphorylated by ATM/ATR and inhibits Fe65-APP-mediated gene transcription.	ATR APP	5.29e-05	4	104	2	25397632
Pubmed	Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.	DST PLEC	5.29e-05	4	104	2	14668477
Pubmed	The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes.	SSH1 SSH2	5.29e-05	4	104	2	17848544
Pubmed	LINC01426 contributes to clear cell renal cell carcinoma progression by modulating CTBP1/miR-423-5p/FOXM1 axis via interacting with IGF2BP1.	FOXM1 CTBP1	5.29e-05	4	104	2	32583425
Pubmed	F-box protein FBXL2 inhibits gastric cancer proliferation by ubiquitin-mediated degradation of forkhead box M1.	FOXM1 SKP1	5.29e-05	4	104	2	26790640
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	RANBP2 ATR COPA PDLIM7 TUBGCP4 INTS3 LIMS1 EXOC2 PLEC	6.49e-05	582	104	9	20467437
Pubmed	FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis.	APP SKP1	8.80e-05	5	104	2	22399757
Pubmed	A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation.	FBXL12 SKP1	8.80e-05	5	104	2	18660753
Pubmed	FBXO31 protects against genomic instability by capping FOXM1 levels at the G2/M transition.	FOXM1 SKP1	8.80e-05	5	104	2	27568981
Pubmed	APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is regulated by its association with Skp1.	ANAPC11 SKP1	8.80e-05	5	104	2	22205987
Pubmed	Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability.	SSH1 SSH2	8.80e-05	5	104	2	20477815
Pubmed	Homozygous MED25 mutation implicated in eye-intellectual disability syndrome.	MED24 MED23	8.80e-05	5	104	2	25792360
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	KNTC1 RANBP2 GAK COPA TUBGCP4 SKP1 WDR3 TIMM8B DST AARS2 COG6 CTBP1 NUP188 EXOC2	9.98e-05	1440	104	14	30833792
Pubmed	Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex.	ATR OOEP	1.32e-04	6	104	2	29125140
Pubmed	Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin.	SSH1 SSH2	1.32e-04	6	104	2	11832213
Pubmed	SCFFbl12 Increases p21Waf1/Cip1 Expression Level through Atypical Ubiquitin Chain Synthesis.	FBXL12 SKP1	1.32e-04	6	104	2	27215384
Pubmed	Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity.	RANBP2 PDLIM7 PBLD SKP1 CTBP1 SSH2 PLEC	1.37e-04	374	104	7	23824909
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RANBP2 TBL1Y PDLIM7 CNOT10 APP SKP1 VIRMA WDR3 MED24 DST RGPD3 CTBP1 EXOC2 MED23	1.50e-04	1497	104	14	31527615
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	RANBP2 COPA SKP1 WDR3 DST CTBP1 NUP188 SSH2 PLEC	1.67e-04	660	104	9	32780723
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	RGPD4 KNTC1 RANBP2 COPA PDLIM7 CNOT10 ANAPC11 TUBGCP4 SKP1 CEP78 RGPD3 NUP188	1.77e-04	1155	104	12	20360068
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD4 RGPD3	1.84e-04	7	104	2	15710750
Pubmed	RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling.	ATR INTS3	1.84e-04	7	104	2	25916848
Pubmed	The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.	DST PLEC	1.84e-04	7	104	2	10637308
Pubmed	There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.	ADGRA2 ADGRA3	1.84e-04	7	104	2	12565841
Pubmed	Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex.	RANBP2 SENP2	1.84e-04	7	104	2	12192048
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KDM3A VPS13C ZNF507 ADGRA2 DST FBXO41 NUP188 MED23	1.95e-04	529	104	8	14621295
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	KNTC1 APP SKP1 WDR3 AARS2 CTBP1 KDM6A	2.00e-04	398	104	7	35016035
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	RGPD4 RANBP2 COPA CTBP1 MED23	2.25e-04	182	104	5	32239614
Pubmed	Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.	RGPD4 RANBP2 COPA RGPD3	2.28e-04	99	104	4	27746211
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	ATR CNOT10 WDR3 MED24 DST AARS2 ZCCHC7	2.39e-04	410	104	7	26949251
Pubmed	Epidermolysis Bullosa Simplex	DST PLEC	2.45e-04	8	104	2	20301543
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	SPTBN5 DST ALMS1 SSH2 PLEC	2.55e-04	187	104	5	26460568
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	RANBP2 PDLIM7 ZNF189 INTS3 VIRMA WDR3 NUP188 ZCCHC7 PLEC ZNF468 MED23 RNF111	2.57e-04	1203	104	12	29180619
Pubmed	Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.	SSH1 SSH2	3.14e-04	9	104	2	15660133
Pubmed	Coordination of Cellular Dynamics Contributes to Tooth Epithelium Deformations.	SSH1 SSH2	3.14e-04	9	104	2	27588418
Pubmed	BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade.	ATR REV1	3.14e-04	9	104	2	23901102
Pubmed	The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun.	FBXL12 SKP1	3.14e-04	9	104	2	17704768
Pubmed	The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1.	MED24 MED23	3.14e-04	9	104	2	9989412
Interaction	SYNE3 interactions	ARHGAP32 RANBP2 GAK COPA PDLIM7 CNOT10 VPS13C APP DST ALMS1 COL14A1 SENP2 PLEC	3.40e-07	444	101	13	int:SYNE3
Cytoband	2q12.3	RGPD4 RANBP2 LIMS1	7.29e-06	17	103	3	2q12.3
Cytoband	15q21	SPTBN5 RNF111	2.71e-04	11	103	2	15q21
Cytoband	4p16	GAK CTBP1	6.63e-04	17	103	2	4p16
Cytoband	6q26	PDE10A PLG	7.45e-04	18	103	2	6q26
Cytoband	Ensembl 112 genes in cytogenetic band chr2q12	RGPD4 LIMS1 RGPD3	8.54e-04	82	103	3	chr2q12
GeneFamily	Slingshot protein phosphatases	SSH1 SSH2	5.22e-05	3	76	2	898
GeneFamily	Immunoglobulin like domain containing\|Adhesion G protein-coupled receptors, subfamily A	ADGRA2 ADGRA3	5.22e-05	3	76	2	911
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD4 RANBP2 CNOT10 RGPD3 KDM6A	1.23e-04	115	76	5	769
GeneFamily	EF-hand domain containing\|Plakins	DST PLEC	4.80e-04	8	76	2	939
ToppCell	facs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KNTC1 ATR SH2B2 AARS2 NUP188 ADGRA3	2.81e-06	170	103	6	d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDLIM7 ABCC9 RUNX1T1 ADGRA2 KCNT2 COL14A1	4.30e-06	183	103	6	667717366cb181b8a04a347e64f0f5a4dfc6ee7f
ToppCell	TCGA-Skin-Metastatic-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	RANBP2 VPS13C KAT6A ABCC9 CD84 ALMS1	6.75e-06	198	103	6	af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCell	TCGA-Skin-Metastatic\|TCGA-Skin / Sample_Type by Project: Shred V9	RANBP2 VPS13C KAT6A ABCC9 CD84 ALMS1	6.75e-06	198	103	6	ad39cce004867f083f8da1954e0cf5a263815184
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	RANBP2 VPS13C KAT6A ABCC9 CD84 ALMS1	6.75e-06	198	103	6	62cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCell	Fetal_29-31_weeks\|World / Lineage, Cell type, age group and donor	PDE10A RUNX1T1 APP KCNT2 COL14A1 ADGRA3	6.95e-06	199	103	6	5b9d355795dd03a22f0961dfd143425c367a4654
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA3A GALNT13 KCNT2 FSHR HEPHL1	3.53e-05	160	103	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	356C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CATSPERE KLHL11 LIMS1 DST SCNN1A	3.53e-05	160	103	5	0293b244c063a62819690bf22bbc2681f8d15252
ToppCell	356C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CATSPERE KLHL11 LIMS1 DST SCNN1A	3.53e-05	160	103	5	3eaae86fa08f7651021316f8e5811bf48055591e
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA3A GALNT13 KCNT2 FSHR HEPHL1	3.53e-05	160	103	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	RANBP2 CATSPERE APP DST ZNF468	5.26e-05	174	103	5	2274648b80dd74f3c948a779bba3391095964c34
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|normal_Lymph_Node / Location, Cell class and cell subclass	RANBP2 CATSPERE APP DST ZNF468	5.56e-05	176	103	5	476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RANBP2 VPS13C KCNT2 COL14A1 KDM6A	5.56e-05	176	103	5	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FLVCR1 TUBGCP4 EXOC2 PLEC IL6R	6.51e-05	182	103	5	c98da2db197b1531204e116600ff51891e5c17af
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYO5B GALNT13 DST KCNT2 SCNN1A	6.86e-05	184	103	5	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	PDLIM7 DST KCNT2 KDM6A IL6R	6.86e-05	184	103	5	d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D122\|Adult / Lineage, Cell type, age group and donor	MYO5B GALNT13 DST KCNT2 SCNN1A	6.86e-05	184	103	5	561592edc3083fad41b91811151b442207c65dd9
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYO5B GALNT13 DST KCNT2 SCNN1A	6.86e-05	184	103	5	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	APP GASK1B CD84 LIMS1 IL6R	7.04e-05	185	103	5	29d7ddcb9a2e45f76cd5611f7c52b6df689effd3
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	APP GASK1B CD84 LIMS1 IL6R	7.04e-05	185	103	5	780bdb63ef913a09930063286011c9108381d3a9
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	APP GASK1B CD84 LIMS1 IL6R	7.04e-05	185	103	5	274b8acccdfe434d14af4cb32fb615c06ec98435
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	APP GASK1B CD84 LIMS1 IL6R	7.04e-05	185	103	5	b640d9ed6a1e6aa595053065bb992efc0402353e
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	MYO5B GALNT13 DST KCNT2 SCNN1A	7.40e-05	187	103	5	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDLIM7 ABCC9 RUNX1T1 ADGRA2 KCNT2	7.59e-05	188	103	5	b2d68a32314e9b099ed74d974079ad96359d1ae3
ToppCell	facs-MAT-Fat-3m\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COPA ABCC9 APP GASK1B COL14A1	7.59e-05	188	103	5	7da9750255efbc5cf9aed7e3105a337fac63b9f0
ToppCell	SupraBC-Differ-KC\|World / shred by cell class for mouse tongue	MYO5B EFNA3 SCNN1A CYP4F22 PSAPL1	7.78e-05	189	103	5	6412741b88e241304033b41effca0c77a374d907
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDLIM7 ABCC9 RUNX1T1 ADGRA2 KCNT2	7.98e-05	190	103	5	5681c211baeed4af82a2bbc13420f6a7b487581c
ToppCell	(1)_T_cells-(1)_T_CD4_fh\|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	APP CD84 LIMS1 SSH2 IL6R	7.98e-05	190	103	5	120ca702600373c208a3d032fede0a040736e5cf
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC9 RUNX1T1 ADGRA2 DST COL14A1	8.18e-05	191	103	5	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC9 RUNX1T1 ADGRA2 KCNT2 COL14A1	8.18e-05	191	103	5	39092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCell	facs-Tongue-nan-18m-Epithelial-suprabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO5B EFNA3 SCNN1A CYP4F22 PSAPL1	8.18e-05	191	103	5	02f24202f9fdd46c648265a5b3b6f9066aa009fc
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	ABCC9 PDE10A RUNX1T1 ADGRA2 KCNT2	8.18e-05	191	103	5	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC9 RUNX1T1 ADGRA2 KCNT2 COL14A1	8.18e-05	191	103	5	ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDLIM7 ABCC9 RUNX1T1 ADGRA2 KCNT2	8.38e-05	192	103	5	24e2f15f5767a97eb3b389922bcfd7b13805e1ce
ToppCell	Control-Myeloid-MoAM4\|Control / Disease group,lineage and cell class （2021.01.30）	APP GASK1B CD84 LIMS1 IL6R	8.38e-05	192	103	5	1da7c303a2e36af4a9d8ec30a11380d9b1897922
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC9 RUNX1T1 ADGRA2 KCNT2 COL14A1	8.59e-05	193	103	5	f1199518c3626fd29bfce65070dd21a660671213
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA3A ABCC9 APP COL14A1 CCT8L1P	8.59e-05	193	103	5	2483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCell	facs-Tongue-nan-18m-Epithelial-keratinocyte\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO5B EFNA3 SCNN1A CYP4F22 PSAPL1	8.80e-05	194	103	5	afc997879e031b49d22a85e107c5849140709b44
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ROBO4 PDE10A RUNX1T1 NEK3 FUT1	8.80e-05	194	103	5	68004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDLIM7 ABCC9 RUNX1T1 ADGRA2 KCNT2	8.80e-05	194	103	5	ebb038f94f49f5c655578d1b018676e10c6b7e3c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDLIM7 ABCC9 RUNX1T1 ADGRA2 KCNT2	9.01e-05	195	103	5	edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	ARHGAP32 PDE10A GASK1B KCNT2 SSH2	9.01e-05	195	103	5	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	Caecum-T_cell-Tfh\|T_cell / Region, Cell class and subclass	APP CD84 RGPD3 PLEC IL6R	9.23e-05	196	103	5	fe2ee5788028e6b671674f0cc50e2b6379f50976
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDLIM7 ABCC9 RUNX1T1 ADGRA2 KCNT2	9.23e-05	196	103	5	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDLIM7 ABCC9 RUNX1T1 ADGRA2 KCNT2	9.23e-05	196	103	5	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	MYO5B VPS13C CSMD2 SCNN1A CAMTA1	9.46e-05	197	103	5	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	RUNX1T1 CSMD2 DST KCNT2 COL14A1	9.46e-05	197	103	5	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	IPF-Myeloid-Macrophage\|Myeloid / Disease state, Lineage and Cell class	APP GASK1B CD84 LIMS1 IL6R	9.92e-05	199	103	5	3c2b362d5e824e1a04830e70352f8818de984174
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-2\|TCGA-Bladder / Sample_Type by Project: Shred V9	RGPD4 ABCC9 RUNX1T1 CSMD2	1.29e-04	111	103	4	aeb2c06beda62f9a79fc73788dd1c5cf9a2f35fe
Disease	adenoid cystic carcinoma (is_implicated_in)	ATR KDM6A	1.06e-04	5	97	2	DOID:0080202 (is_implicated_in)
Disease	epidermolysis bullosa simplex (is_implicated_in)	DST PLEC	2.22e-04	7	97	2	DOID:4644 (is_implicated_in)
Disease	cerebellar ataxia (implicated_via_orthology)	VPS13C AARS2	2.96e-04	8	97	2	DOID:0050753 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	KDM3A SSH1 CTBP1 SSH2 KDM6A	4.72e-04	195	97	5	DOID:1574 (implicated_via_orthology)
Disease	N-delta-acetylornithine measurement	ALMS1 FBXO41	6.91e-04	12	97	2	EFO_0800067
Disease	alpha-L-iduronidase measurement	GAK CTBP1	1.41e-03	17	97	2	EFO_0020139
Disease	anorectal malformation	ZNF507 CSMD2	1.76e-03	19	97	2	MONDO_0019938
Disease	blood metabolite measurement	ALMS1 EXOC2	1.76e-03	19	97	2	EFO_0005664
Disease	red blood cell density measurement	ATR FLVCR1 PDE10A DST CEP78 SSH2 PLEC CAMTA1 HCRTR2	2.47e-03	880	97	9	EFO_0007978
Disease	chronotype measurement	GLYAT PDE10A RUNX1T1 KCNT2 FSHR ZCCHC7 CAMTA1 ADGRA3 HCRTR2	2.50e-03	882	97	9	EFO_0008328
Disease	sensory peripheral neuropathy, remission	FOXM1 RUNX1T1	2.59e-03	23	97	2	EFO_0009785, MONDO_0002321
Disease	cognitive function measurement	KNTC1 PDLIM7 CNOT10 RUNX1T1 APP ADGRA2 NEK3 EFNA3 ALMS1 EXOC2 ADGRA3 REV1	2.60e-03	1434	97	12	EFO_0008354
Disease	vasculitis	GAK PLG	2.82e-03	24	97	2	EFO_0006803

Protein segments in the cluster

Peptide	Gene	Start	Entry
HMVEWWTKAHNLLCQ	NT5C3B	101	Q969T7
HMHCILKWLHAQQVQ	ANAPC11	56	Q9NYG5
MSRACWAKSKHLIHS	CAMTA1	1046	Q9Y6Y1
SDHLVASEKQHMLQW	BLOC1S5	131	Q8TDH9
QSGCLHEAQTWKSMI	CATSPERE	801	Q5SY80
MSVRICQQDHHWSGK	CSMD2	2751	Q7Z408
VNKDHLTAATHWASM	CTBP1	351	Q13363
MDVCETHLHWHTVAK	APP	141	P05067
SRKGWHMLLNLCFHI	ADGRA2	801	Q96PE1
LHKAAWNCDHVLMHM	ASB4	256	Q9Y574
SLKSWHMLVNLCFHI	ADGRA3	791	Q8IWK6
RAHAWNMKFNLAHDC	ALMS1	2511	Q8TCU4
TVEWMGLTAAKNLHH	ABCC9	1056	O60706
CNLTWQGADHMAKIL	CEP78	186	Q5JTW2
NITSNTKHLVHLDWM	DMXL1	1131	Q9Y485
LKVCANHWITTTMNL	RANBP2	2081	P49792
WSQHLGKKEMHAFQC	PBLD	241	P30039
HTMDLGKHQWDLDTC	RABEPK	66	Q7Z6M1
QFTTSILRHWCMKHD	INTS3	871	Q68E01
ARMVTHILKSNSWLH	MMP10	461	P09238
AEEWKHLDHLLNCIM	RUNX1T1	351	Q06455
NVLTLWHESHINMKS	DST	961	Q03001
SSMDVTHAHLVNKFW	GLYAT	171	Q6IB77
VKATVLQQLGWMHHT	KDM6A	241	O15550
VEHAKDMLQLWCHAS	PNMA6E	341	A0A0J9YXQ4
HNCLLTAEWMSASKI	EXOC2	46	Q96KP1
AQHKWILQLMHSCKE	EXOC2	376	Q96KP1
NWKHAVTVAHCMYAI	PDE10A	516	Q9Y233
HAFAMTCIWIHLNRK	MED23	421	Q9ULK4
WKNHSHESMAVRLVT	KNTC1	1951	P50748
ELQHCWALQMQRKHL	TUBGCP4	491	Q9UGJ1
WLAKHALENMINDLH	KCNT2	171	Q6UVM3
WISMKAGAIHANTHL	RFPL4B	181	Q6ZWI9
WITDTQNVAHLHKMA	CRLF2	286	Q9HC73
SLQILQDSVKWHHMA	MROH9	11	Q5TGP6
CSITNMHAKNLAIVW	ARHGAP32	511	A7KAX9
EIMHALKMTWHVHCF	PDLIM7	351	Q9NR12
AHKFHAQCIRPWLMQ	DZIP3	1166	Q86Y13
NWFTQMCLGVNHIHK	NEK3	106	P51956
VIMLKCHHMRGNQLW	GALNT13	491	Q8IUC8
VKSMLLCLAWFHREH	OOEP	106	A6NGQ2
TILQQHMKKCGWFHP	KAT6A	551	Q92794
GNVLVCVAVWKNHHM	HCRTR2	71	O43614
ANEHLALAAMHTLWF	PXDNL	961	A1KZ92
LKVCANHWITTTMNL	RGPD3	1106	A6NKT7
MLAWLHQATASEKEH	COG6	311	Q9Y2V7
CTEIHHHEWSKMALF	GASK1B	356	Q6UWH4
NMHAWLRQDHKNVCV	GAK	491	O14976
VFSMLDHLTQWARHK	ATR	1581	Q13535
TTWMVKDLQHHCVIH	IL6R	266	P08887
NTWEHVCSLMTRKHS	KLHL11	431	Q9NVR0
VMVSGVHHKLNSELW	KDM3A	976	Q9Y4C1
THNLHWKCLRMKVFV	EFNA3	151	P52797
QAKHVEMTSLCAHWQ	COL14A1	926	Q05707
WSADMSHVALLAKHA	COPA	496	P53621
KCGSVQQHLFWVTML	FLVCR1	191	Q9Y5Y0
SKFLAMLAQWCTQAH	FBXO41	601	Q8TF61
GKWMITCQVSDHLQA	HEPHL1	341	Q6MZM0
WKNSIRHNLSLHDMF	FOXM1	281	Q08050
ERWHTITHAMQLDCK	FSHR	466	P23945
CEIHLQWKSGHMAES	DNER	616	Q8NFT8
CSQHNRMKTAFWAVL	SCNN1A	76	P37088
NQSADIMHAKWRHLA	CYP4F22	176	Q6NT55
WKDFALLTQCNHTIM	FUT1	291	P19526
VCHLVMKHTYINVWT	TAS2R20	141	P59543
VCHLVMKHTYINVWT	TAS2R36	141	P0DTE0
NSDLNLLEWTHHSMK	SENP2	521	Q9HC62
LKVCANHWITTTMNL	RGPD4	1106	Q7Z3J3
QEQHAILASSKEMWH	SOHLH1	111	Q5JUK2
AVQHCQKHVWKEMHL	PSAPL1	501	Q6NUJ1
LHSCEISMAWLHKQQ	FBXL12	131	Q9NXK8
QMKWHEACLSISAAI	MED24	571	O75448
MAQHHLWILLLCLQT	CD84	1	Q9UIB8
PMNHLTKLVAHACWA	CCT8L1P	176	A6NM43
PMDHLTKLVAHACWA	CCT8L2	176	Q96SF2
NAMGKQWHVEHFVCA	LIMS1	206	P48059
KKCQSWSSMTPHRHQ	PLG	396	P00747
LGCMAKHTATHLLNW	AARS2	626	Q5JTZ9
ELHQFCHLSNMELSW	SPTBN5	1521	Q9NRC6
CHLSNMELSWVAEHM	SPTBN5	1526	Q9NRC6
AILKHRMDHSDSQWL	ROBO4	511	Q8WZ75
QAMWSALQVLHKACE	SSH1	176	Q8WYL5
MHHQWLLLAACFWVI	CHST10	1	O43529
WNNLGCIHFAMSKHN	CNOT10	296	Q9H9A5
AASFLQMWHVVDKCT	ZBTB43	106	O43298
RISLIQHQKLHTAWM	ZNF189	611	O75820
MHLFHQVCVDQWLIT	RNF111	961	Q6ZNA4
AMWSALQSLHKACEV	SSH2	176	Q76I76
SRLHHISMWKCELTE	REV1	356	Q9UBZ9
ILQLSNFMKEWHFHL	NUP188	1456	Q5SRE5
NAAILKKVIQWCTHH	SKP1	51	P63208
TWKKCRFQHPSTMHI	VPS13C	766	Q709C8
QCHVQHLWFQSVLDM	SH2B2	476	O14492
LWVSSSMVCILHRHK	VN1R4	196	Q7Z5H5
LVTLWHQLHVDMKSL	PLEC	1016	Q15149
HQLHVDMKSLLAWQS	PLEC	1021	Q15149
WSMKQDACVHDLQAH	TBL1Y	386	Q9BQ87
TAQVHHFMELCWDKC	TIMM8B	26	Q9Y5J9
TCGQQRMLKTHAWKH	ZNF507	256	Q8TCN5
LHIDEILSHCWMQPK	TSSK1B	261	Q9BXA7
MLDHSCLFRHSWDKQ	ZCCHC7	291	Q8N3Z6
WDLDTQHCFKTMVGH	WDR3	176	Q9UNX4
LNTRKLWSMHLHVQA	VIRMA	1141	Q69YN4
LWSMHLHVQAKLLQE	VIRMA	1146	Q69YN4
SLHSSLLTQKWEVHM	ZNF468	196	Q5VIY5
LQTHILWNESHRCME	TYW1B	331	Q6NUM6
TDAACHEAMQWVTHL	VWA3A	1016	A6NCI4
QMEHWLCHRKLVTTS	MYO5B	371	Q9ULV0