Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase regulatory subunit binding

DAB2IP PTPN13 FAM83A

7.16e-05141193GO:0036312
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase binding

DAB2IP PDGFRA PTPN13 FAM83A

1.24e-04431194GO:0043548
GeneOntologyBiologicalProcessmacromolecule deacylation

FLNA HDAC6 FRY CPT1C DESI1

3.29e-05631205GO:0098732
GeneOntologyBiologicalProcessfollicular dendritic cell differentiation

BCL3 NFKB2

3.36e-0521202GO:0002268
GeneOntologyCellularComponentBcl3/NF-kappaB2 complex

BCL3 NFKB2

3.21e-0521192GO:0033257
GeneOntologyCellularComponentI-kappaB/NF-kappaB complex

BCL3 NFKB2

1.91e-0441192GO:0033256
MousePhenointermingled spleen red and white pulp

PCSK1 BCL3 KIF15 NFKB2

3.04e-0615994MP:0008475
MousePhenoabnormal kidney morphology

ABCA1 COL17A1 PDGFRA SGSH RBM10 LMTK2 E2F2 IL17RC ARHGEF17 ADAR SLC26A1 FAM83H DHX8 LRRC55 PBRM1 ZFP36L2 PREP GLYR1 DCHS1 AKAP11 ABCC2 MEX3B MMUT NOTCH3 CCN3

6.36e-0613639925MP:0002135
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

DNHD1 FLNA NSD1 ARHGEF17 ADAR PARP1 PBRM1 NOM1 ASPM CAMSAP1

9.54e-092341201036243803
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

ACACA RBM10 WRNIP1 LMTK2 ADAR TRIP10 PARP1 PBRM1 NUP210 CAMSAP1 ESPL1

3.96e-074401201134244565
Pubmed

A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.

RBM10 PTPN13 STRAP WDR77

7.71e-0721120424923560
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

HDAC6 ACACA WRNIP1 UNC45A FAM83H STRAP ZFP36L2 PPM1F NOM1 NUP210 MAP2K3 WDR77

1.34e-066061201236538041
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DAB2IP RAD51 TRPM4 FLNA ACACA OBSCN NSD1 LMTK2 FRMD8 FAM83H PWWP2B ZFP36L2 PIK3C2B NFKB2 CAMSAP1 ESPL1

1.36e-0611051201635748872
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

TCEA1 FLNA ACACA EIF4H ADAR DHX8 PTPN13 STRAP NOM1 CAMSAP1 ESPL1 MAP2K3 WDR77

1.41e-067241201336232890
Pubmed

GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity.

HDAC6 BCL3 NFKB2

3.31e-069120315469820
Pubmed

Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.

PCSK1 PCSK1N PCSK4

4.72e-0610120316163737
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

ACACA PDGFRA LMTK2 UNC45A ARHGEF17 FAM83H PTPN13 KCNA7 ZFP36L2 PIK3C2B AKAP11 CAMSAP1 MEX3B

9.19e-068611201336931259
Pubmed

PARP-1 regulates mouse embryonic neural stem cell proliferation by regulating PDGFRα expression.

PDGFRA PARP1

1.18e-052120232295715
Pubmed

Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1.

PCSK1 PCSK1N

1.18e-052120211435430
Pubmed

Mutations in NRXN1 and NRXN2 in a patient with early-onset epileptic encephalopathy and respiratory depression.

NRXN1 NRXN2

1.18e-052120230709877
Pubmed

The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers.

BCL3 NFKB2

1.18e-05212028453667
Pubmed

RBM10 C761Y mutation induced oncogenic ASPM isoforms and regulated β-catenin signaling in cholangiocarcinoma.

RBM10 ASPM

1.18e-052120238576051
Pubmed

Detection of aberrant methylation of HOXA9 and HIC1 through multiplex MethyLight assay in serum DNA for the early detection of epithelial ovarian cancer.

HIC1 HOXA9

1.18e-052120232191343
Pubmed

Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.

NRXN1 NRXN2

1.18e-052120226595880
Pubmed

Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells.

HDAC6 NOTCH3

1.18e-052120229643474
Pubmed

Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study.

PCSK1 PCSK1N

1.18e-052120219528091
Pubmed

Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.

ABCA1 PARP1

1.18e-052120227026705
Pubmed

RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H.

EIF4H RBM10

1.18e-052120233130397
Pubmed

Functional consequences of a novel variant of PCSK1.

PCSK1 PCSK1N

1.18e-052120223383060
Pubmed

The DNA topoisomerase IIbeta binding protein 1 (TopBP1) interacts with poly (ADP-ribose) polymerase (PARP-1).

TOPBP1 PARP1

1.18e-052120217340632
Pubmed

Diverse effects of BCL3 phosphorylation on its modulation of NF-kappaB p52 homodimer binding to DNA.

BCL3 NFKB2

1.18e-05212029407099
Pubmed

Association of PCSK1 rs6234 with obesity and related traits in a Chinese Han population.

PCSK1 PCSK1N

1.18e-052120220498726
Pubmed

A role for the IkappaB family member Bcl-3 in the control of central immunologic tolerance.

BCL3 NFKB2

1.18e-052120217869136
Pubmed

BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages.

BCL3 NFKB2

1.18e-052120215465827
Pubmed

Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin.

NRXN1 NRXN2

1.18e-05212021621094
Pubmed

Distinct activities of p52/NF-kappa B required for proper secondary lymphoid organ microarchitecture: functions enhanced by Bcl-3.

BCL3 NFKB2

1.18e-052120210586052
Pubmed

Mutational analysis of FLASH and PTPN13 genes in colorectal carcinomas.

CASP8AP2 PTPN13

1.18e-052120218038312
Pubmed

Interrogating the Significance of PARP1 Expression and PBRM1 Mutation as Biomarkers for Predicting the Response to Atezolizumab plus Bevacizumab or to Sunitinib in Patients with Clear Cell Renal Cell Carcinoma.

PARP1 PBRM1

1.18e-052120235688666
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

DAB2IP CASP8AP2 NRXN1 NRXN2 PPP1R16B AKAP11 GRIP2

1.38e-05225120712168954
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

FLNA ACACA WRNIP1 CCT2 UNC45A ADAR FAM83H PARP1 STRAP NUP210 WDR77

1.39e-056381201133239621
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RAD51 CASP8AP2 FLNA ACACA UNC45A PTPN13 KIF15 PPM1F CAMSAP1

1.55e-05418120934709266
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

FLNA ACACA RBM10 NSD1 CCT2 UNC45A ADAR PTPN13 STRAP SAP30BP

2.18e-055491201038280479
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

ACACA WRNIP1 NSD1 AKAP11 CAMSAP1 ESPL1 MAP2K3

2.21e-05242120734011540
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

DAB2IP FLNA WRNIP1 ZCCHC2 TRIP10 CDC123 GLYR1 GRIP2 NOTCH3 CCN3

2.58e-055601201021653829
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

TCEA1 FLNA RBM10 NSD1 DHX8 PARP1 NUP210

2.72e-05250120733536335
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

RAD51 RBM10 ANXA7 WRNIP1 TOPBP1 NSD1 FAM83H MED22 MAP2K3

2.91e-05453120929656893
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

FLNA ACACA RBM10 WRNIP1 TOPBP1 CCT2 ADAR PARP1

3.53e-05357120837059091
Pubmed

Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx.

NRXN1 NRXN2

3.53e-053120238891114
Pubmed

The chromatin-remodeling subunit Baf200 promotes homology-directed DNA repair and regulates distinct chromatin-remodeling complexes.

RAD51 PBRM1

3.53e-053120228381560
Pubmed

The soluble ligand Y box-1 activates Notch3 receptor by binding to epidermal growth factor like repeats 20-23.

EGF NOTCH3

3.53e-053120230321499
Pubmed

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.

ABCA1 HDAC6

3.53e-053120216192271
Pubmed

Spatiotemporal signaling underlies progressive vascular rarefaction in myocardial infarction.

HIC1 PDGFRA

3.53e-053120238129410
Pubmed

FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth.

FRMD8 FRMD8P1

3.53e-053120237527040
Pubmed

Spatio-temporal profiling of Filamin A RNA-editing reveals ADAR preferences and high editing levels outside neuronal tissues.

FLNA ADAR

3.53e-053120224025532
Pubmed

alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.

NRXN1 NRXN2

3.53e-053120216406382
Pubmed

RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer.

RAD51 PARP1

3.53e-053120228034904
Pubmed

Hypoxia-inducible factor-1α and poly [ADP ribose] polymerase 1 cooperatively regulate Notch3 expression under hypoxia via a noncanonical mechanism.

PARP1 NOTCH3

3.53e-053120235714766
Pubmed

Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.

NRXN1 NRXN2

3.53e-053120231005376
Pubmed

Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition.

RAD51 PARP1

3.53e-053120220373286
Pubmed

METTL3 promotes homologous recombination repair and modulates chemotherapeutic response in breast cancer by regulating the EGF/RAD51 axis.

RAD51 EGF

3.53e-053120235502895
Pubmed

DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors.

RAD51 PARP1

3.53e-053120231029033
Pubmed

Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3.

BCL3 NFKB2

3.53e-053120212055593
Pubmed

Gonadotropin-releasing hormone antagonist cetrorelix down-regulates proliferating cell nuclear antigen and epidermal growth factor expression and up-regulates apoptosis in association with enhanced poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human leiomyoma cells.

PARP1 EGF

3.53e-053120215536154
Pubmed

Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.

NRXN1 NRXN2

3.53e-053120226446217
Pubmed

The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth.

FRMD8 FRMD8P1

3.53e-053120236720499
Pubmed

Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

NRXN1 NRXN2

3.53e-053120211944992
Pubmed

Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.

NRXN1 NRXN2

3.53e-053120233058888
Pubmed

Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.

NRXN1 NRXN2

3.53e-053120217035546
Pubmed

Neurexins: three genes and 1001 products.

NRXN1 NRXN2

3.53e-05312029448462
Pubmed

Deletion of α-neurexin II results in autism-related behaviors in mice.

NRXN1 NRXN2

3.53e-053120225423136
Pubmed

Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior.

NRXN1 NRXN2

3.53e-053120234133920
Pubmed

ProSAAS and prohormone convertase 1 are broadly expressed during mouse development.

PCSK1 PCSK1N

3.53e-053120215018810
Pubmed

Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia.

NRXN1 NRXN2

3.53e-053120221424692
Pubmed

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.

RAD51 TOPBP1

3.53e-053120226811421
Pubmed

The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.

NRXN1 NRXN2

3.53e-053120230858964
Pubmed

RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy.

RAD51 PARP1

3.53e-053120227507046
Pubmed

Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.

NRXN1 NRXN2

3.53e-053120228013231
Pubmed

Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion.

NRXN1 NRXN2

3.53e-053120231812984
Pubmed

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.

RAD51 FLNA

3.53e-053120227391408
Pubmed

Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.

NRXN1 NRXN2

3.53e-053120212036300
Pubmed

β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling.

NRXN1 NRXN2

3.53e-053120226213384
Pubmed

Neurexin gene family variants as risk factors for autism spectrum disorder.

NRXN1 NRXN2

3.53e-053120229045040
Pubmed

Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization.

NRXN1 NRXN2

3.53e-053120238571813
Pubmed

Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons.

NRXN1 NRXN2

3.53e-053120235173587
Pubmed

Alternative NF-κB signaling promotes colorectal tumorigenesis through transcriptionally upregulating Bcl-3.

BCL3 NFKB2

3.53e-053120229973688
Pubmed

Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51.

RAD51 PARP1

3.53e-053120233531658
Pubmed

Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter.

BCL3 NFKB2

3.53e-053120216940298
Pubmed

Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.

ABCA1 PARP1

3.53e-053120235393951
Pubmed

Neurexins are differentially expressed in the embryonic nervous system of mice.

NRXN1 NRXN2

3.53e-05312027722633
Pubmed

Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.

RAD51 TOPBP1 PARP1

3.73e-0519120321478856
Pubmed

The Effect of the NFκB-USP9X-Cx43 Axis on the Dynamic Balance of Bone Formation/Degradation during Ossification of the Posterior Longitudinal Ligament of the Cervical Spine.

FLNA CCT2 PARP1 WDR77

3.73e-0554120435391932
Pubmed

Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.

RAD51 HFE PDGFRA E2F2 PARP1 EGF

3.84e-05179120619074885
Pubmed

Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.

CDC42BPG HDAC6 TRIP10 PREP AKAP11 MMUT

4.35e-05183120631932471
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

CASP8AP2 FLNA ACACA RBM10 UNC45A PARP1 GLYR1 NUP210 DCHS1 GRIP2 WDR77

6.31e-057541201135906200
Pubmed

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.

ACACA ANXA7 WRNIP1 CCT2 PIK3C2B NFKB2 ESPL1

6.65e-05288120723383273
Pubmed

Role of STRAP in regulating GSK3β function and Notch3 stabilization.

STRAP NOTCH3

7.05e-054120221502811
Pubmed

Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3.

BCL3 NFKB2

7.05e-054120216108830
Pubmed

Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism.

NRXN1 NRXN2

7.05e-054120232706374
Pubmed

Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation.

AACS MMUT

7.05e-054120230913280
Pubmed

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.

NRXN1 NRXN2

7.05e-05412028786425
Pubmed

Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.

NRXN1 NRXN2

7.05e-054120217347997
Pubmed

Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins.

NRXN1 NRXN2

7.05e-054120235385735
Pubmed

Neurexins regulate presynaptic GABAB-receptors at central synapses.

NRXN1 NRXN2

7.05e-054120233888718
Pubmed

EGF-induced sodium influx regulates EGFR trafficking through HDAC6 and tubulin acetylation.

HDAC6 EGF

7.05e-054120226382850
Pubmed

Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.

NRXN1 NRXN2

7.05e-054120214983056
Pubmed

Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.

HIC1 PDGFRA

7.05e-054120231809738
Pubmed

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.

PCSK1 PCSK4

7.05e-054120210701998
Pubmed

Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors.

HIC1 PDGFRA

7.05e-054120231978365
InteractionENTPD4 interactions

TTYH1 HFE LRRC55 CDC123

3.78e-06191164int:ENTPD4
GeneFamilyPWWP domain containing

NSD1 PWWP2B GLYR1

1.30e-04228231147
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

HDAC6 LMTK2 BCL2L2 NOM1 PPP1R16B AKAP11

1.73e-04181826694
GeneFamilyProprotein convertase subtilisin/kexin family

PCSK1 PCSK4

7.17e-049822973
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

FRMD8 PLEKHH1 PTPN13

1.51e-03508231293
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000_k-means-cluster#2

CASP8AP2 ZBTB12 PCDH17 EML5 KIF15 NRXN2 PIK3C2B NUP210 ASPM LSS

1.50e-0532811810Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000_K2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RAD51 E2F2 PCDH17 KIF15 ASPM ESPL1 MEX3B

3.58e-071671207bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 FLNA ARHGEF17 FRY SUSD2 GRIP2 NOTCH3

5.71e-0717912078da6863edc756540bb097cc7221c1408640d9bb4
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 FLNA ARHGEF17 FRY SUSD2 GRIP2 NOTCH3

5.71e-071791207f39c13c99a07d009cc677e363ffe089089c64916
ToppCell(00)_Basal-(1)_GFP|(00)_Basal / shred by cell type by condition

FRMD8 ZBTB12 BCL3 TRIP10 MAP2K3 NOTCH3 FAM83A

1.16e-061991207105b15157f35df3fdf857e306f11e4e8200e05d4
ToppCellDividing_Macrophages-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

RAD51 E2F2 KIF15 ASPM ESPL1 CCN3

8.86e-0617812061893fadac2ec3d5de0a641e57b7b2f962012a9ba
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-granulocyte-monocyte_progenitor|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAD51 E2F2 SLC26A1 KIF15 NUP210 ESPL1

9.15e-061791206804aa3899585fc7e662eff9f6d41f48655f16dd6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PCDH17 LRRC55 PIK3C2B PPM1F DCHS1 PPP1R16B

9.15e-0617912068f9e538c822940785130297712b75131812a4603
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIC1 COL17A1 PCDHB7 NRXN2 CPT1C DCHS1

1.25e-051891206ce5b3d53c9a5457a5a02b221dee18334b5eaf8b7
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

PCDH17 USHBP1 PIK3C2B PPM1F NUP210 PPP1R16B

1.32e-05191120644c596984c6196f6014e0e405dbe5560841e54ff
ToppCellE16.5-samps-Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

PCDH17 USHBP1 PIK3C2B PPM1F NUP210 PPP1R16B

1.32e-051911206e7521d4d24f016d4e531cd492a7a69604f0c9e6f
ToppCellwk_15-18-Epithelial-PNS-FGFBP2+_Neural_progenitor|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

BCL2L2 EML5 NRXN1 PREP NOM1 MEX3B

1.36e-051921206ab54d4bfc61ef7e3d765afe6e4a6d7011a301ecd
ToppCelldroplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PARP1 KIF15 NRXN1 PREP ASPM PPP1R16B

1.44e-0519412068ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCellBLOOD--(1)_T_cell-(1)_Activated_T_cells|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

RAD51 FLNA E2F2 PARP1 KIF15 ASPM

1.44e-0519412066a0cbb9d5c5c4effb02dff654c6c3b184026875c
ToppCell343B-Myeloid-Dendritic-cDC_proliferating_1|343B / Donor, Lineage, Cell class and subclass (all cells)

RAD51 E2F2 CD1A KIF15 ASPM ESPL1

1.49e-05195120647a01b8a92eebeb34ac7f70bf1ab4613a326e24f
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RAD51 PCDH17 KIF15 ASPM DCHS1 ESPL1

1.53e-051961206eb8c9a4a5eb21d43ff7b25deae5896c236f669b9
ToppCellTransverse-B_cell-B_cell_IgG_Plasma|B_cell / Region, Cell class and subclass

DAB2IP RBM10 HEATR5A BCL3 FAM83H ABCC2

1.58e-051971206a0a096e8e80763a92d5d7396eb678a4587771a3a
ToppCell10x5'-GI_large-bowel-Lymphocytic_B-GC_B_(I)|GI_large-bowel / Manually curated celltypes from each tissue

RAD51 E2F2 PARP1 KIF15 ASPM ESPL1

1.58e-05197120680a0cfbd454409594effead7082586b06c2f411a
ToppCellmetastatic_Lymph_Node-T/NK_cells-Undetermined|metastatic_Lymph_Node / Location, Cell class and cell subclass

RAD51 E2F2 KIF15 ASPM SH2D1A ESPL1

1.62e-051981206f9f083c76c51b6f014ecf80eaec957eff8d1ab75
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TTYH1 PDGFRA PCDH17 NRXN1 SUSD2 PCSK1N

1.62e-05198120601d563ccdc0da02dac04169e713844fecb4233a1
ToppCellproximal-Hematologic-Proliferating_NK/T|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 TOPBP1 E2F2 KIF15 ASPM SH2D1A

1.62e-0519812066c894fda309ec3d4bb446f63d5dde4e7f8c4fd89
ToppCellproximal-3-Hematologic-Proliferating_NK/T|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 TOPBP1 E2F2 KIF15 ASPM SH2D1A

1.62e-0519812062777c5efe84ce3dbbe6175ecc1c987bc816ab74b
ToppCellproximal-Hematologic-Proliferating_NK/T-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 TOPBP1 E2F2 KIF15 ASPM SH2D1A

1.62e-0519812062e121899f58a5024e26441bd326aac12c37fe6d1
ToppCellBiopsy_Control_(H.)-Epithelial-Proliferating_Epithelial_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

RAD51 E2F2 KIF15 SUSD2 ASPM ESPL1

1.67e-0519912064fcf5bec207e4384fd73c5e8801a7e414e3ee7b0
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TTYH1 PDGFRA PCDH17 NRXN1 SUSD2 PCSK1N

1.67e-05199120604e5cfb85c681fd3f4c1151062e4a0f460b55d5f
ToppCellsevere-Lymphocytic-Prol._cells|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

RAD51 CCT2 PARP1 KIF15 ASPM SH2D1A

1.67e-051991206b24315952b6ac6c8d2d3a7bd949a5b5392624d4e
ToppCellLPS-IL1RA-Unknown-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIF15 NRXN2 MOCS3 ASPM NOTCH3

1.71e-051181205aefad0b35aff980b6a2a98057735442e8a65ab04
ToppCellLPS-IL1RA-Unknown|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIF15 NRXN2 MOCS3 ASPM NOTCH3

1.71e-0511812056cb4063b83f867b782080ce5b1199b51bb277f2a
ToppCellmedial-Hematologic-Proliferating_NK/T-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 E2F2 KIF15 ASPM SH2D1A ESPL1

1.72e-052001206ab1f9f99cb4a381a642a2cfb32e7f8d276c2dda4
ToppCellCOVID_non-vent-Lymphocytic-Proliferative_Lymphocyte-|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

RAD51 E2F2 KIF15 ASPM SH2D1A ESPL1

1.72e-05200120604bf9e6a0fbd792b49eed63dabba5d6fafed8c07
ToppCellBiopsy_IPF-Immune-Proliferating_T_cells|Biopsy_IPF / Sample group, Lineage and Cell type

RAD51 E2F2 KIF15 ASPM SH2D1A ESPL1

1.72e-052001206c43d1a83b2a8ad060f3d80c9438da8b7a5e307fb
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte-|COVID_vent / Disease condition, Lineage, Cell class and subclass

RAD51 TOPBP1 E2F2 KIF15 ASPM SH2D1A

1.72e-0520012067e4c0db43a03ca11380a54f44a3cf1991e055b80
ToppCellmedial-Hematologic-Proliferating_NK/T|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 E2F2 KIF15 ASPM SH2D1A ESPL1

1.72e-052001206bfde42e00a9a6b858937de87cd19c9ed3677d954
ToppCellBiopsy_Control_(H.)-Immune-Proliferating_T_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

RAD51 E2F2 KIF15 ASPM SH2D1A ESPL1

1.72e-052001206dd374e153106fff8a22483ba7f63b3fa3d3ab2ea
ToppCellCOVID_non-vent-Lymphocytic-Proliferative_Lymphocyte|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

RAD51 E2F2 KIF15 ASPM SH2D1A ESPL1

1.72e-052001206f6b5320cdfe640a71e6e2df26f30d42e64b1c921
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte|COVID_vent / Disease condition, Lineage, Cell class and subclass

RAD51 TOPBP1 E2F2 KIF15 ASPM SH2D1A

1.72e-0520012069775ca7dedb76fcbb74f80f86b33c94e394c320a
ToppCellmedial-2-Hematologic-Proliferating_NK/T|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 E2F2 KIF15 ASPM SH2D1A ESPL1

1.72e-0520012063d1895490dd262e9246eb280938239a7253451dd
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIK3C2B ASPM FSCN2 PPP1R16B SH2D1A

2.25e-05125120535042ed43045dddc341b76cc5f9fe31b5ba0abb8
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIK3C2B ASPM FSCN2 PPP1R16B SH2D1A

2.34e-0512612054eeea015efe17e0aae5bd76b71fa70b5149dfada
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_B-ABC_aged-B_naive|lymph-node_spleen / Manually curated celltypes from each tissue

ABCA1 TRIP10 SLC26A1 KIF15 ESPL1

6.90e-0515812057098847804dd90fa1dd74536e4e90f989b630fe4
ToppCellClub_cells-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

PCDH17 GRHL1 PREP NOTCH3 FAM83A

7.32e-051601205b261a3a49c850d92bc9e04fc3527c752dfe37a1a
ToppCellMild-MAIT|Mild / Disease group and Cell class

DAB2IP HIC1 FRY GRHL1 PTPN13

7.54e-0516112050c1a04485708d5302600cdc2d7dac1cb76b4033a
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTYH1 CDC42BPG FAM219B PTPN13 PCSK4

7.99e-051631205a24db9d266a40f3bffe4f18d277bc269791b4560
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAD51 ZBTB12 PCDH17 USHBP1 ASPM

7.99e-0516312057864e966c228282b4b63c43164dba3faba21026d
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_2|390C / Donor, Lineage, Cell class and subclass (all cells)

RAD51 E2F2 KIF15 ASPM ESPL1

8.23e-051641205ad508f53009efdd1dae7abcdb5431387f3f7e7b2
ToppCellLPS-antiTNF-Epithelial_airway-Mes-Epi-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAD51 KIF15 NRXN1 ASPM ESPL1

8.23e-0516412054307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCellLPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAD51 KIF15 NRXN1 ASPM ESPL1

8.23e-0516412051d84aa5b925f502ee9c5fa39714490f613a58028
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

RAD51 E2F2 KIF15 ASPM ESPL1

8.47e-051651205a5c3af634d2698f9a01cf074791756b7669f9fff
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Proliferating_NK|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAD51 GRHL1 KIF15 NUP210 SH2D1A

8.71e-05166120521ba5fd755c0fb31ada42a1b5d60bede0153323d
ToppCellDividing_Macrophages-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

RAD51 E2F2 KIF15 ASPM ESPL1

8.71e-051661205ea95b94ccc2ac67df741b30c27f4ae698925875f
ToppCell343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell|343B / Donor, Lineage, Cell class and subclass (all cells)

E2F2 HOXA9 KIF15 ASPM ESPL1

8.96e-051671205315cde87eed2b42a1b9b068fae94caa10ec64c70
ToppCell10x5'-Lung-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|Lung / Manually curated celltypes from each tissue

E2F2 KCNA7 KIF15 ASPM ESPL1

8.96e-05167120582739226347d74897be000f429b73543a031af96
ToppCell10x5'-Lung-Hematopoietic_progenitors|Lung / Manually curated celltypes from each tissue

E2F2 KCNA7 KIF15 ASPM ESPL1

8.96e-051671205dec18caf0475002d4ad3c7bc7fc3050cbc8e6bae
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCDH17 SEMA6D PIK3C2B MOCS3 PPP1R16B

8.96e-051671205774f3264318b002d0df5d06d41d645366038d0bf
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

OBSCN LMTK2 KIF15 MED22 DCHS1

9.22e-0516812058697b40b2ec2cce68ef3beb4792eb3eff29be053
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK1 PTPN13 KIF15 ASPM FAM83A

9.22e-051681205a7eb28e15b591997f1aee09501cb20ae18beca08
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EGF KIF15 ASPM SH2D1A ESPL1

9.74e-0517012052d5e56eee0c3ce75a9641cc14dee0e0807141c32
ToppCell390C-Lymphocytic-NK_cells-Proliferating_NK_cell|390C / Donor, Lineage, Cell class and subclass (all cells)

RAD51 PSD2 KIF15 ASPM ESPL1

9.74e-0517012055319f73cff64f2bb67472c7156ee1d0f006c6fc0
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDGFRA HOXA9 KIF15 ZFP36L2 ASPM

9.74e-051701205a7184dc41f90caa753860ed0f65a18133f84bc5f
ToppCell10x5'-bone_marrow-Lymphocytic_NK-Cycling_NK|bone_marrow / Manually curated celltypes from each tissue

RAD51 E2F2 KIF15 ASPM ESPL1

1.06e-0417312058a9dd85f718564c07cf3120ad648daeb60c94fc5
ToppCellAdult-Mesenchymal-pericyte_cell-D175|Adult / Lineage, Cell type, age group and donor

CCNP OBSCN ARHGEF17 SEMA6D NOTCH3

1.06e-041731205fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D|PND01-03-samps / Age Group, Lineage, Cell class and subclass

PCDH17 SEMA6D USHBP1 PIK3C2B PPP1R16B

1.09e-041741205b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Cycling_T|GI_small-bowel / Manually curated celltypes from each tissue

RAD51 E2F2 KIF15 ASPM ESPL1

1.09e-041741205e4c8da80eca07e4396f57dad212f76c2eca4c1bd
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CDC42BPG ACACA OBSCN PLEKHH1 NOTCH3

1.09e-041741205207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK1 FAM83H NRXN1 PCSK1N PCSK4

1.12e-0417512058362a46f5804333baa84cd56d450bc147f372a7e
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK1 FAM83H NRXN1 PCSK1N PCSK4

1.12e-0417512058b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LMTK2 ZBTB12 FAM83H PIK3C2B SUSD2

1.12e-041751205711ace94fa9a763c6ae48171a690953f25deebe4
ToppCell3'-Adult-LymphNode-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNA ARHGEF17 CPT1C SUSD2 NOTCH3

1.15e-04176120556e19240f4a7b617a986e3c0854b757394e78251
ToppCell390C-Lymphocytic-NK_cells-Proliferating_NK_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RAD51 PSD2 KIF15 ASPM ESPL1

1.15e-0417612058813c01ea080f373fe3970c5e1ba4c2dca0f7f02
ToppCell3'-Adult-LymphNode-Mesenchymal-Pericytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNA ARHGEF17 CPT1C SUSD2 NOTCH3

1.15e-041761205c88b46fe29ae7606c8880a6ff0ebb85c0dfda8bd
ToppCelldroplet-Bladder-nan-24m-Hematologic-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 PSD2 PPP1R16B SH2D1A FAM83A

1.15e-0417612050089b50d607f4d2f18639fab0f3fc779227baa7a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_26.46.91|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CASP8AP2 PDGFRA PCDHB7 NRXN2 NOTCH3

1.15e-04176120529b71369503719c74888cd356ceb6724cfdcabd9
ToppCellwk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

HEATR5A PCDH17 EML5 NRXN1 GRIP2

1.18e-04177120515a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCell368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

RAD51 E2F2 KIF15 ASPM ESPL1

1.18e-041771205844017225e9039d1bc621a9630a30c2e9a51b36d
ToppCell368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RAD51 E2F2 KIF15 ASPM ESPL1

1.18e-04177120526c25d10aa511b64cc7db43a8deea7b5d31bca96
ToppCellNS-moderate-d_0-4-Lymphoid-NKT-proliferating|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RAD51 E2F2 KIF15 SUSD2 ASPM

1.18e-041771205174c54acfe19e2bb31418d69e228032ba724cbb6
ToppCellwk_15-18-Epithelial-Proximal_epithelial-GHRL+_NE_precursor|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PCSK1 NRXN1 FSCN2 PCSK1N PERCC1

1.21e-04178120532cc4155267baf1b536a61310044e6502d09531f
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 ABCA1 EML5 TMEM65 AKAP11

1.21e-041781205fcbbcc44271515de1969b4732b6441c012693d5f
ToppCellC_00|World / shred on cell type and cluster

ZFP36L2 NOM1 NFKB2 NUP210 ASPM

1.24e-041791205da2dadc3266ffebd4a34ac61bfa05fddcadcde4c
ToppCellfacs-Skin-Anagen-3m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL17RC BCL3 GRHL1 SUSD2 NOTCH3

1.24e-0417912054a072526c3a524a7aed99bdb32a07a1ce1f48972
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial-Proliferative_Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

PCDH17 USHBP1 PIK3C2B NUP210 PPP1R16B

1.24e-041791205d24513a404c9b1d37dd47aa1cdb5713b64b88f89
ToppCellfacs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB2IP ARHGEF17 LSS GRIP2 NOTCH3

1.27e-041801205a37cc885fe3f6cb9df69d43358064c83c18412e7
ToppCellfacs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 ARHGEF17 SUSD2 GRIP2 NOTCH3

1.27e-0418012050059e5acade6c895fd629767bea1c15f40b0d1b0
ToppCellfacs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB2IP ARHGEF17 LSS GRIP2 NOTCH3

1.27e-04180120563a6d532b16b8b15c7c9102148d7297ee3afd641
ToppCellfacs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 ARHGEF17 SUSD2 GRIP2 NOTCH3

1.27e-041801205dfb8412e1e06fa7349e66eea2ef27d9ea98b7893
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Cycling_Myeloid-Mac|lymph-node_spleen / Manually curated celltypes from each tissue

PDGFRA KIF15 ASPM ESPL1 NOTCH3

1.27e-0418012054eea8366cdb82c356325ce88f09ad8b302c17a07
ToppCelldroplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF17 NRXN1 SUSD2 GRIP2 NOTCH3

1.27e-04180120578fdcfb3fdbf36469cae78407cda5bd0996930d8
ToppCell5'-Adult-Appendix-Neuronal-Glial_mature|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TTYH1 PCDH17 PTPN13 NRXN1 PCSK1N

1.31e-0418112053aa81ac64d0cc9a74fbfa71e2176740548e7cd06
ToppCell5'-Adult-Appendix-Neuronal-Glial_mature-Adult_Glia|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TTYH1 PCDH17 PTPN13 NRXN1 PCSK1N

1.31e-041811205997ba1be2824b00d684f2163d0114656ed11fa53
ToppCelldroplet-Heart-nan-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB2IP PCDH17 USHBP1 PIK3C2B PPP1R16B

1.31e-04181120592d44892bb15771f0ab5fe61879b204b0acbd9b3
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

E2F2 HOXA9 NUP210 ASPM ESPL1

1.31e-041811205e4dbc09f0210de465d8347969b301c22463a2b7d
ToppCell5'-Adult-Appendix-Neuronal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TTYH1 PCDH17 PTPN13 NRXN1 PCSK1N

1.31e-041811205e6b7e8dd5c13cc10ba22f2f5a8c669486f934bdc
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-1|bone_marrow / Manually curated celltypes from each tissue

RAD51 E2F2 KIF15 ASPM ESPL1

1.31e-041811205ccd0ed30cea3fb41d34f28b3e8d80a94493bef3c
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASP8AP2 NSD1 HOXA9 ZFP36L2 SH2D1A

1.34e-041821205e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASP8AP2 NSD1 HOXA9 ZFP36L2 SH2D1A

1.34e-0418212051710eab3037a87609d21838be2d2d29c3bc36651
ToppCell10x5'-Liver-Lymphocytic_T_CD4/8-lo-Cycling_T|Liver / Manually curated celltypes from each tissue

RAD51 E2F2 KIF15 USHBP1 ASPM

1.34e-04182120581557cdc88777f3bd4e1dd18a760b08fc29122ef
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF17 LRRC55 KIF15 NRXN1 NOTCH3

1.34e-041821205c84f44391932080df31c8765e363c3dff64b2bd1
ToppCellwk_15-18-Epithelial-PNS-Early_Schwann|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TTYH1 PCDH17 EML5 NRXN1 GRIP2

1.38e-0418312057e8366ec8117d36cec67f77dcb0e9a6032d87fcb
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 FRMD8 PTPN13 ZFP36L2 SH2D1A

1.41e-0418412058c23945bafe8926f25836bc208115edd5214a2b0
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_B-GC_B_(I)|lymph-node_spleen / Manually curated celltypes from each tissue

RAD51 E2F2 KIF15 ASPM ESPL1

1.41e-041841205057c6c2f570914fa4af84682589a86b61547d6c9
ToppCelldroplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF17 NRXN1 SUSD2 GRIP2 NOTCH3

1.41e-041841205f4344f3c407b2d4d703fe56e43d84dbfe60ba833
DrugDichlorodiphenyl Dichloroethylene

CASP8AP2 ACACA PDGFRA BCL2L2 PARP1 EGF NRXN1 NRXN2 ABCC2 NOTCH3

4.32e-0630211910ctd:D003633
DrugProtein Kinase Inhibitors

ACACA PDGFRA PARP1 EGF ABCC2

7.65e-06521195ctd:D047428
DrugProtriptyline hydrochloride [1225-55-4]; Down 200; 13.4uM; PC3; HT_HG-U133A

SGSH RBM10 BCL2L2 UNC45A NPEPL1 PREP PPM1F MAP2K3

8.73e-0619511986338_DN
DrugChrysene-1,4-quinone [100900-16-1]; Down 200; 15.4uM; PC3; HT_HG-U133A

PDGFRA NSD1 BCL2L2 HOXA9 PPM1F AKAP11 CAMSAP1 ESPL1

9.07e-0619611987139_DN
DrugSulfamonomethoxine [1220-83-3]; Up 200; 14.2uM; MCF7; HT_HG-U133A

RAD51 HFE PDGFRA SGSH PARP1 PPM1F ABCC2 NOTCH3

9.41e-0619711983484_UP
DrugDiflunisal [22494-42-4]; Down 200; 16uM; MCF7; HT_HG-U133A

HFE NSD1 IL17RC NPEPL1 HOXA9 ZFP36L2 NUP210 CAMSAP1

9.76e-0619811984794_DN
DrugDideoxyadenosine

EGF ABCC2

2.71e-0521192ctd:D016048
DrugAC1NQVPA

RAD51 MMUT

2.71e-0521192CID005229480
DrugIsotretinoin [4759-48-2]; Up 200; 13.4uM; HL60; HT_HG-U133A

ABCA1 SGSH BCL3 HOXA9 ZFP36L2 PPP1R16B PCSK1N

3.06e-0516911972407_UP
Drugamphotericin B, deoxycholate drug combination

RAD51 FLNA TOPBP1 BCL3 EGF NFKB2 NUP210 ASPM PCSK4 NOTCH3

3.09e-0537911910ctd:C059765
DrugBortezomib

RAD51 HDAC6 SGSH OBSCN BCL2L2 BCL3 ZCCHC2 PARP1 FRY CCDC82 PPM1F CPT1C NFKB2 ABCC2 OSGIN1

3.19e-0583811915ctd:D000069286
DiseaseAlopecia

PARP1 LSS ABCC2

5.48e-05191163C0002170
Diseasestomach cancer (is_marker_for)

DAB2IP ADAR PARP1 ASPM CCN3

2.51e-041421165DOID:10534 (is_marker_for)
Diseasemicrocephaly (is_implicated_in)

NSD1 ASPM

4.22e-0481162DOID:10907 (is_implicated_in)
DiseaseColorectal Carcinoma

ABCA1 ACACA RBM10 OBSCN PARP1 STRAP ZFP36L2 PPM1F DCHS1 ABCC2

4.62e-0470211610C0009402
Diseasemitral valve prolapse (is_implicated_in)

FLNA DCHS1

5.42e-0491162DOID:988 (is_implicated_in)
Diseasereading

SEMA6D NRXN1 DESI1

6.51e-04431163EFO_0005229
DiseaseAdenoid Cystic Carcinoma

NSD1 ASPM PCSK1N ESPL1

6.65e-041001164C0010606
DiseaseMalignant neoplasm of salivary gland

ASPM PCSK1N ESPL1

7.45e-04451163C0220636
DiseaseSalivary Gland Neoplasms

ASPM PCSK1N ESPL1

8.46e-04471163C0036095
Diseaselung adenocarcinoma (is_implicated_in)

RBM10 PTPN13 EGF

9.56e-04491163DOID:3910 (is_implicated_in)
DiseaseLiver Cirrhosis, Experimental

FLNA PDGFRA PLEKHH1 FRY SEMA6D EGF PLA2G12A TMEM65 ABCC2 OSGIN1

9.76e-0477411610C0023893
DiseaseGlioblastoma Multiforme

CDC42BPG PDGFRA EGF NOTCH3

9.82e-041111164C1621958
DiseaseAmelogenesis Imperfecta

COL17A1 FAM83H

9.86e-04121162C0002452
Diseaseamyloid plaque accumulation rate

MOCS3 DESI1

9.86e-04121162EFO_0007646
DiseaseBreast Carcinoma

RAD51 FLNA HIC1 ADAR PARP1 PBRM1 EGF NOTCH3

1.32e-035381168C0678222
DiseaseAlopecia, Male Pattern

PARP1 ABCC2

1.56e-03151162C4083212
DiseaseAndrogenetic Alopecia

PARP1 ABCC2

1.56e-03151162C0162311
DiseaseFemale pattern alopecia (disorder)

PARP1 ABCC2

1.56e-03151162C0263477
Diseaseobesity (implicated_via_orthology)

PCSK1 HDAC6 DCHS1 PCSK1N NOTCH3

1.63e-032151165DOID:9970 (implicated_via_orthology)
DiseaseAtherosclerosis

ABCA1 BCL3 PARP1

1.64e-03591163C0004153
DiseaseAtherogenesis

ABCA1 BCL3 PARP1

1.64e-03591163C1563937
Diseaseliver fat measurement, liver disease biomarker

HFE SLC30A10

1.77e-03161162EFO_0006845, EFO_0010821
DiseaseDermatitis

PARP1 EGF

1.77e-03161162C0011603
DiseaseProfound Mental Retardation

NSD1 PARP1 FRY NRXN1

2.25e-031391164C0020796
DiseaseMental Retardation, Psychosocial

NSD1 PARP1 FRY NRXN1

2.25e-031391164C0025363
DiseaseMental deficiency

NSD1 PARP1 FRY NRXN1

2.25e-031391164C0917816
Diseaseserum hepcidin measurement

HFE AKAP11

2.25e-03181162EFO_0004504
Diseasenon-alcoholic fatty liver disease (is_implicated_in)

HFE ABCC2

2.25e-03181162DOID:0080208 (is_implicated_in)
DiseasePseudopelade

PARP1 ABCC2

2.51e-03191162C0086873
DiseaseC-reactive protein measurement

PCSK1 ABCA1 CCNP BCL3 ZCCHC2 NPEPL1 ADAR PCDH17 LRRC55 AACS CCN3 OSGIN1

2.84e-03120611612EFO_0004458
Diseasemelanoma

HDAC6 PDGFRA HOXA9 PARP1 CPT1C

3.03e-032481165C0025202
DiseaseProstatic Neoplasms

DAB2IP TRPM4 HDAC6 LMTK2 IL17RC PARP1 EGF ZFP36L2

3.05e-036161168C0033578
DiseaseMalignant neoplasm of prostate

DAB2IP TRPM4 HDAC6 LMTK2 IL17RC PARP1 EGF ZFP36L2

3.05e-036161168C0376358
Diseasetransient cerebral ischemia (biomarker_via_orthology)

BCL2L2 PARP1 PTPN13 NRXN1

3.48e-031571164DOID:224 (biomarker_via_orthology)
DiseaseGlioblastoma

PDGFRA EGF NOTCH3

3.77e-03791163C0017636

Protein segments in the cluster

PeptideGeneStartEntry
DYGAALRGLCEDALE

TTYH1

376

Q9H313
YRVLLALREADSGAG

USHBP1

356

Q8N6Y0
GVSRLEEAQAYLAAG

BARGIN

641

Q6ZT62
ASGDGSLLSLDYAEL

COL17A1

1116

Q9UMD9
VGAACGLALESYDDL

AACS

36

Q86V21
VSLDSDSDGELGSRY

FAM219B

121

Q5XKK7
DDRLSDLGISSYGIS

ABCA1

1226

O95477
VHRLSDGGLLLSYDG

ACACA

706

Q13085
EFTALYGDGALEEAR

BCL2L2

146

Q92843
RTLEDLTLDSGYGGA

BTBD11

11

A6QL63
SSLGLEGDLYEDNLS

AKAP11

1766

Q9UKA4
AGDTSGDYRRLLLAI

ANXA7

471

P20073
LLVRYLGVGADASSD

DNHD1

4561

Q96M86
EEALSALGLQGEREY

CCNP

66

Q9H8S5
DEGSLDIYAGLDSAV

CASP8AP2

26

Q9UKL3
RDGSDGAALLAVIHY

CAMSAP1

246

Q5T5Y3
LLAFSRDFLSGEGDL

ASPM

926

Q8IZT6
RGLVAAYSGESDSEE

RBM10

726

P98175
ELSYRSLGEDVSDSG

NSD1

866

Q96L73
RALDSDFGESGRLTY

PCDH17

611

O14917
LLAVAERYGLSGSDV

RAD51

171

Q06609
ERYGLSGSDVLDNVA

RAD51

176

Q06609
IEVAYSLLRGGSDDS

PARP1

771

P09874
YAGGDLLTLLSRFED

CDC42BPG

151

Q6DT37
ELSNGEAGEAYRSLS

ARHGEF17

721

Q96PE2
GLDEQRLSADSGYII

PDGFRA

1006

P16234
NRDGAASLSYRVLDG

NUP210

1311

Q8TEM1
GFEGYIDLGRELSSL

DAB2IP

606

Q5VWQ8
EGTFALDAASGRLYL

DCHS1

1376

Q96JQ0
DTYLNAALDLLGGED

PLA2G12A

46

Q9BZM1
VRVDSSSGLGDYLEL

NRXN1

131

P58400
YGSESEEDAALAAAR

PBRM1

351

Q86U86
KEALTYDGALLGDRS

EIF4H

96

Q15056
DLDLSYGGLAFLSLE

LRRC55

166

Q6ZSA7
DLLDSASAGLYLREH

KIF15

176

Q9NS87
IYTGRLADGAEAAAA

HIC1

101

Q14526
GARAADVLVYLADDT

FRMD8

26

Q9BZ67
EAYGRLDLDTDSADG

MED22

151

Q15528
GARAADVLVYLADDT

FRMD8P1

26

Q9BZ68
YLRATLEVAAGEAAD

CD1A

261

P06126
RYLLGRILAGSADSE

PCSK1N

196

Q9UHG2
YGLLDAGLLVDTART

PCSK4

431

Q6UW60
TDAEGRLVLADGVSY

NPEPL1

341

Q8NDH3
YADLVRLARGGSLED

PERCC1

131

A0A1W2PR82
ILAAGDRGLYEDCSS

GLYR1

401

Q49A26
YVDSFLLGADAADEL

HOXA9

11

P31269
LLGADAADELSVGRY

HOXA9

16

P31269
REQTGLEAYALGLDT

LSS

46

P48449
ATRALLLYLDDGGDC

NRXN2

61

Q9P2S2
SAADYLGALSAVERL

NOTCH3

1606

Q9UM47
FDERSRGHLDEGLSY

LMTK2

486

Q8IWU2
YLGGDDLDTSAIRHD

ABCC2

616

Q92887
RLATDALLDGGSEAY

FAM83A

36

Q86UY5
DLGLSLFEALGYVDD

HFE

41

Q30201
VRVDSSSGLGDYLEL

NRXN1

1166

Q9ULB1
RLGYSEDGLEELSRH

LRIT1

576

Q9P2V4
RLLGSVDYDGINDAI

PIK3C2B

221

O00750
YSTADELARTGDADL

OBSCN

4786

Q5VST9
AGANGYLRAAELLLD

PPP1R16B

236

Q96T49
GGAELSDDGRYVLLS

PREP

236

P48147
ARDLDTGSNGEIAYA

PCDHB7

266

Q9Y5E2
ASLDAYAHALLAGRG

CPT1C

431

Q8TCG5
ALDESFLGTLYDGTR

CCDC82

351

Q8N4S0
LGSLLELAELACDGY

ESPL1

71

Q14674
CSSDGLLDLVYADLG

HEATR5A

1431

Q86XA9
INGDEDSAAALGLLY

GRHL1

51

Q9NZI5
YGLGAAALARLREDE

KCNA7

96

Q96RP8
GISDLFDSYDLGDLL

E2F2

421

Q14209
ADGYDLEILDGTRGT

ADAR

1131

P55265
DYLLDDGTLVVSGRD

CDC123

36

O75794
DEEDSLGGLTLAAYR

CCN3

176

P48745
YDEAGTGLLSVADFR

EFCAB6

1446

Q5THR3
SEVAGSLYRADLDGV

EGF

176

P01133
DTRDAGYGGLSLSIE

FLNA

2071

P21333
EYLSSLGESLFRGEA

DESI1

86

Q6ICB0
ARDELTYSGALNGDI

EML5

206

Q05BV3
LTCDAASYLGDNLRG

FRY

2721

Q5TBA9
SLEGGYNLRALAEGV

HDAC6

381

Q9UBN7
AVDALAEGGSEAYSR

FAM83H

31

Q6ZRV2
GGLAARSDLLNIGDY

GRIP2

81

Q9C0E4
GTLDLEARNYDGLTA

BCL3

231

P20749
AELVGELNGYLRDSS

PWWP2B

351

Q6NUJ5
SRAGLYLREDGALSI

PPP4R1L

276

Q9P1A2
LAAAGVGRLGLVDYD

MOCS3

101

O95396
LYTLGALDDEGLLTR

DHX8

961

Q14562
ALLLYSADDSGFERL

IL17RC

586

Q8NAC3
LEAARYRSDGALLLG

WDR77

31

Q9BQA1
IGAGLSAADAVLYAR

OSGIN1

291

Q9UJX0
ADAASRALTGSEDYL

PPM1F

341

P49593
EARYSDGSIALDIFG

PTPN13

341

Q12923
ADDLVTISELGRGAY

MAP2K3

61

P46734
RSSHLGRYLSAEEDG

FSCN2

61

O14926
LSLLGLDSDEGASLY

MEX3B

41

Q6ZN04
NGRGEYVLLEAALTD

SUSD2

466

Q9UGT4
LATGLDGSYLLRDSE

SH2D1A

21

O60880
LDSGASRDDDLLLPY

NAGPA

26

Q9UK23
GGSLADSYLDEGFLL

CCT2

206

P78371
FARDGLDYILGALES

NOM1

211

Q5C9Z4
ALRTGDDYIAIGADE

TCEA1

151

P23193
LLLLADDGGFESGAY

SGSH

26

P51688
DGELYASGSEDGTLR

STRAP

276

Q9Y3F4
ALSSRYLGDSGLDDF

SERTAD3

136

Q9UJW9
RLDYAGSDLTAYLLG

ACTL7A

241

Q9Y615
RLGAGYGLLSEAELE

TRIP10

226

Q15642
YLALLGSENREAAGR

ZCCHC2

176

Q9C0B9
RGSADYNSLSEEERG

SLC7A6OS

266

Q96CW6
SLDTYGSDGLSRRDA

SLC30A10

436

Q6XR72
ALGSDDEYGRQGLSI

TAS1R3

211

Q7RTX0
LRADSGSDGAYRLEL

nan

131

Q6ZTK2
CYSLSEDAEGEGLLL

ZBTB12

266

Q9Y330
ALLARIGDTAFYEDA

SLC26A1

511

Q9H2B4
AGVLAEGDNASRSLY

PSD2

101

Q9BQI7
ESAEADGLAESSYGR

SOGA1

1051

O94964
LVSDAYGEDDFSRLG

SAP30BP

41

Q9UHR5
DEDYEAGGTRRLLSS

PLEKHH1

746

Q9ULM0
SDLAGLGLAGYVEAL

TMEM65

166

Q6PI78
TLAYLSDGDARAGLN

WRNIP1

431

Q96S55
DLDDDLSLGRGYEAI

TTC29

306

Q8NA56
AETYRLLGGADLAQG

TTC23

356

Q5W5X9
STLEYDGEEISGLAR

SEMA6D

151

Q8NFY4
AALLYGTGGAEDLLA

ZFP36L2

331

P47974
SELNGIAASLGADYR

TOPBP1

921

Q92547
YSGEDDELLQRAAAG

UNC45A

826

Q9H3U1
GSSEASAYLDELRLA

TRPM4

386

Q8TD43
LADGLEYSRTGLQAG

MMUT

281

P22033
ASAIAEELGYDLLGQ

PCSK1

46

P29120
SLLRSYELAGGDLAG

NFKB2

816

Q00653