Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	kainate selective glutamate receptor activity	GRIK1 GRIK2	3.96e-05	6	33	2	GO:0015277
GeneOntologyMolecularFunction	extracellularly glutamate-gated ion channel activity	GRIK1 GRIK2	5.53e-05	7	33	2	GO:0005234
GeneOntologyMolecularFunction	glutamate-gated receptor activity	GRIK1 GRIK2	3.55e-04	17	33	2	GO:0004970
GeneOntologyMolecularFunction	ligand-gated sodium channel activity	GRIK1 GRIK2	3.99e-04	18	33	2	GO:0015280
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GRIK1 GRIK2	7.15e-04	24	33	2	GO:0099507
GeneOntologyMolecularFunction	glutamate receptor activity	GRIK1 GRIK2	9.06e-04	27	33	2	GO:0008066
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	GRIK1 RYR1	1.20e-03	31	33	2	GO:0099604
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	GRIK1 GRIK2 RYR1	1.58e-03	140	33	3	GO:0099094
GeneOntologyMolecularFunction	microtubule binding	ALMS1 MAP4 NEIL2 STARD9	1.60e-03	308	33	4	GO:0008017
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	MAN2C1 NEIL2 OTOGL	1.71e-03	144	33	3	GO:0016798
GeneOntologyMolecularFunction	excitatory extracellular ligand-gated monoatomic ion channel activity	GRIK1 GRIK2	2.29e-03	43	33	2	GO:0005231
GeneOntologyMolecularFunction	sodium channel activity	GRIK1 GRIK2	3.34e-03	52	33	2	GO:0005272
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	GRIK1 GRIK2 RYR1	3.92e-03	193	33	3	GO:0015276
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GRIK1 GRIK2	3.99e-03	57	33	2	GO:1904315
GeneOntologyMolecularFunction	ligand-gated channel activity	GRIK1 GRIK2 RYR1	4.15e-03	197	33	3	GO:0022834
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GRIK1 GRIK2	4.42e-03	60	33	2	GO:0099529
GeneOntologyMolecularFunction	transmitter-gated channel activity	GRIK1 GRIK2	5.16e-03	65	33	2	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GRIK1 GRIK2	5.16e-03	65	33	2	GO:0022824
GeneOntologyMolecularFunction	tubulin binding	ALMS1 MAP4 NEIL2 STARD9	5.21e-03	428	33	4	GO:0015631
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GRIK1 GRIK2	6.82e-03	75	33	2	GO:0098960
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	GRIK1 GRIK2	7.17e-03	77	33	2	GO:0005230
GeneOntologyCellularComponent	kainate selective glutamate receptor complex	GRIK1 GRIK2	3.61e-05	6	33	2	GO:0032983
Domain	Iontro_rcpt	GRIK1 GRIK2	4.01e-04	18	31	2	IPR001320
Domain	Lig_chan	GRIK1 GRIK2	4.01e-04	18	31	2	PF00060
Domain	Lig_chan-Glu_bd	GRIK1 GRIK2	4.01e-04	18	31	2	PF10613
Domain	PBPe	GRIK1 GRIK2	4.01e-04	18	31	2	SM00079
Domain	Iono_rcpt_met	GRIK1 GRIK2	4.01e-04	18	31	2	IPR001508
Domain	Glu/Gly-bd	GRIK1 GRIK2	4.01e-04	18	31	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIK1 GRIK2	4.01e-04	18	31	2	SM00918
Domain	ANF_receptor	GRIK1 GRIK2	1.71e-03	37	31	2	PF01094
Domain	ANF_lig-bd_rcpt	GRIK1 GRIK2	1.71e-03	37	31	2	IPR001828
Domain	Peripla_BP_I	GRIK1 GRIK2	1.90e-03	39	31	2	IPR028082
Pathway	REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS	GRIK1 GRIK2	1.35e-04	10	25	2	M10272
Pathway	REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS	GRIK1 GRIK2	1.97e-04	12	25	2	MM15142
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TNKS1BP1 CEP192 PLEKHG2 PLEC MORC3 ALMS1 DSC2 MAP4 STARD9	7.58e-08	861	33	9	36931259
Pubmed	CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly.	CEP192 BNIP3L ALMS1	9.30e-08	10	33	3	22895009
Pubmed	Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation.	GRIK1 GRIK2	8.73e-07	2	33	2	12947409
Pubmed	Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.	GRIK1 GRIK2	8.73e-07	2	33	2	15537878
Pubmed	Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.	GRIK1 GRIK2	8.73e-07	2	33	2	24760837
Pubmed	Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice.	GRIK1 GRIK2	8.73e-07	2	33	2	15673679
Pubmed	Subunit composition of kainate receptors in hippocampal interneurons.	GRIK1 GRIK2	8.73e-07	2	33	2	11144357
Pubmed	A mosaic of functional kainate receptors in hippocampal interneurons.	GRIK1 GRIK2	8.73e-07	2	33	2	15483117
Pubmed	Contribution of aberrant GluK2-containing kainate receptors to chronic seizures in temporal lobe epilepsy.	GRIK1 GRIK2	8.73e-07	2	33	2	25043179
Pubmed	Functional characterization of kainate receptors in the mouse nucleus accumbens.	GRIK1 GRIK2	8.73e-07	2	33	2	11985817
Pubmed	RNA editing of human kainate receptor subunits.	GRIK1 GRIK2	8.73e-07	2	33	2	7696618
Pubmed	Q/R site editing controls kainate receptor inhibition by membrane fatty acids.	GRIK1 GRIK2	8.73e-07	2	33	2	16221857
Pubmed	Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus.	GRIK1 GRIK2	8.73e-07	2	33	2	11182092
Pubmed	Altered long-term synaptic plasticity and kainate-induced Ca2+ transients in the substantia gelatinosa neurons in GLU(K6)-deficient mice.	GRIK1 GRIK2	8.73e-07	2	33	2	16219388
Pubmed	Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6.	GRIK1 GRIK2	8.73e-07	2	33	2	8260617
Pubmed	Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex.	GRIK1 GRIK2	8.73e-07	2	33	2	15928066
Pubmed	Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: a potential role for kainate receptors.	GRIK1 GRIK2	8.73e-07	2	33	2	15358807
Pubmed	Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit.	GRIK1 GRIK2	8.73e-07	2	33	2	14724198
Pubmed	Subunit composition and alternative splicing regulate membrane delivery of kainate receptors.	GRIK1 GRIK2	8.73e-07	2	33	2	15014126
Pubmed	Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences.	GRIK1 GRIK2	8.73e-07	2	33	2	8700852
Pubmed	Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus.	GRIK1 GRIK2	8.73e-07	2	33	2	11069933
Pubmed	The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones.	GRIK1 GRIK2	8.73e-07	2	33	2	15539395
Pubmed	Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor.	GRIK1 GRIK2	2.62e-06	3	33	2	27346345
Pubmed	Cloning and functional expression of a cDNA encoding the mouse beta 2 subunit of the kainate-selective glutamate receptor channel.	GRIK1 GRIK2	2.62e-06	3	33	2	1379666
Pubmed	Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors.	GRIK1 GRIK2	2.62e-06	3	33	2	8730589
Pubmed	The kainate receptor antagonist UBP310 but not single deletion of GluK1, GluK2, or GluK3 subunits, inhibits MPTP-induced degeneration in the mouse midbrain.	GRIK1 GRIK2	2.62e-06	3	33	2	31513786
Pubmed	Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillations.	GRIK1 GRIK2	2.62e-06	3	33	2	15509753
Pubmed	RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue.	GRIK1 GRIK2	2.62e-06	3	33	2	7523595
Pubmed	Differential trafficking of GluR7 kainate receptor subunit splice variants.	GRIK1 GRIK2	2.62e-06	3	33	2	15805114
Pubmed	Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice.	GRIK1 GRIK2	2.62e-06	3	33	2	9880586
Pubmed	Genetic evidence for the requirement of adenylyl cyclase 1 in synaptic scaling of forebrain cortical neurons.	GRIK1 GRIK2	5.23e-06	4	33	2	17650106
Pubmed	Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses.	GRIK1 GRIK2	5.23e-06	4	33	2	16354929
Pubmed	The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors.	GRIK1 GRIK2	5.23e-06	4	33	2	26277340
Pubmed	Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool.	GRIK1 GRIK2	5.23e-06	4	33	2	15513934
Pubmed	Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses.	GRIK1 GRIK2	5.23e-06	4	33	2	20081851
Pubmed	Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses.	GRIK1 GRIK2	5.23e-06	4	33	2	19369569
Pubmed	Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain.	GRIK1 GRIK2	5.23e-06	4	33	2	25556835
Pubmed	Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17.	GRIK1 GRIK2	5.23e-06	4	33	2	17174564
Pubmed	Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice.	GRIK1 GRIK2	5.23e-06	4	33	2	30241548
Pubmed	Developmental expression patterns of kainate receptors in the mouse spinal cord.	GRIK1 GRIK2	8.72e-06	5	33	2	23076118
Pubmed	Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition.	GRIK1 GRIK2	8.72e-06	5	33	2	28854365
Pubmed	Molecular determinants of kainate receptor trafficking.	GRIK1 GRIK2	8.72e-06	5	33	2	18358623
Pubmed	Kainate receptors: pharmacology, function and therapeutic potential.	GRIK1 GRIK2	8.72e-06	5	33	2	18793656
Pubmed	Development of laminar distributions of kainate receptors in the somatosensory cortex of mice.	GRIK1 GRIK2	8.72e-06	5	33	2	9593973
Pubmed	Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.	GRIK1 GRIK2	8.72e-06	5	33	2	28228252
Pubmed	Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn.	GRIK1 GRIK2	8.72e-06	5	33	2	12223554
Pubmed	RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.	GRIK1 GRIK2	8.72e-06	5	33	2	1717158
Pubmed	Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains.	GRIK1 GRIK2	8.72e-06	5	33	2	29058671
Pubmed	N-glycan content modulates kainate receptor functional properties.	GRIK1 GRIK2	1.31e-05	6	33	2	28714086
Pubmed	Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP.	GRIK1 GRIK2	1.31e-05	6	33	2	12597860
Pubmed	Neto1 is an auxiliary subunit of native synaptic kainate receptors.	GRIK1 GRIK2	1.31e-05	6	33	2	21734292
Pubmed	PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome.	TNKS1BP1 ALMS1 MAP4	1.39e-05	49	33	3	31762063
Pubmed	Glutamate receptors in cortical plasticity: molecular and cellular biology.	GRIK1 GRIK2	1.83e-05	7	33	2	9016303
Pubmed	Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.	GRIK1 GRIK2	1.83e-05	7	33	2	19342380
Pubmed	Glutamate receptors: brain function and signal transduction.	GRIK1 GRIK2	1.83e-05	7	33	2	9651535
Pubmed	Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate.	GRIK1 GRIK2	1.83e-05	7	33	2	1310861
Pubmed	Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.	GRIK1 GRIK2	1.83e-05	7	33	2	17428973
Pubmed	Transmembrane topology of the glutamate receptor subunit GluR6.	GRIK1 GRIK2	2.44e-05	8	33	2	8163463
Pubmed	Expression of glutamate receptor subunit genes during development of the mouse retina.	GRIK1 GRIK2	3.13e-05	9	33	2	9051806
Pubmed	Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data.	GRIK1 GRIK2	3.13e-05	9	33	2	34100982
Pubmed	The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.	GRIK1 GRIK2	5.73e-05	12	33	2	11891216
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	CEP192 BNIP3L MAN2C1 NEIL2 PLXNA1 NRK	6.64e-05	750	33	6	11230166
Pubmed	Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.	GRIK1 GRIK2	6.77e-05	13	33	2	20859245
Pubmed	HEY1 functions are regulated by its phosphorylation at Ser-68.	TNKS1BP1 CEP192 PLEC	1.01e-04	95	33	3	27129302
Pubmed	EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.	TNKS1BP1 PLEC	1.81e-04	21	33	2	33029523
Pubmed	Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.	GRIK1 GRIK2	2.18e-04	23	33	2	8464923
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIK1 GRIK2	2.38e-04	24	33	2	35746896
Pubmed	Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.	GRIK1 GRIK2	2.38e-04	24	33	2	22534482
Pubmed	Proteomic characterization of the human centrosome by protein correlation profiling.	CEP192 ALMS1	2.80e-04	26	33	2	14654843
Pubmed	BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.	TNKS1BP1 PLEC MAP4	4.38e-04	156	33	3	32850835
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TNKS1BP1 PLEC ALMS1 LCORL	6.39e-04	418	33	4	34709266
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	CEP192 ALMS1 MAP4	7.07e-04	184	33	3	32908313
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	PLEC ALMS1 PLXNA1	7.41e-04	187	33	3	26460568
Interaction	C6orf141 interactions	PLEC MORC3 ALMS1 NACC2	1.33e-05	92	32	4	int:C6orf141
Interaction	GRIK4 interactions	GRIK1 GRIK2	6.80e-05	8	32	2	int:GRIK4
Interaction	YWHAG interactions	PPIP5K1 CEP192 PLEKHG2 MORC3 ALMS1 DSC2 AKAP17A STARD9 AFAP1L1	9.95e-05	1248	32	9	int:YWHAG
Interaction	GRIK3 interactions	GRIK1 GRIK2	1.09e-04	10	32	2	int:GRIK3
GeneFamily	Glutamate ionotropic receptor kainate type subunits	GRIK1 GRIK2	1.28e-05	5	21	2	1199
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	CEP192 RYR1	1.85e-02	181	21	2	694
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG2 AFAP1L1	2.35e-02	206	21	2	682
GeneFamily	Ankyrin repeat domain containing	NFKBIZ ANKRD34B	3.17e-02	242	21	2	403
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Sema3e_Kank4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ANKRD34B NACC2 STARD9	1.23e-04	135	32	3	54b2aaf8d322e01a3ff6099c2422d68ecccf96b4
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Akr1c18_Ntf3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ANKRD34B NACC2 STARD9	1.65e-04	149	32	3	1e77f03d2b32f366018fec3462d1b75f6e7febb9
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	GRIK2 PLEC PLXNA1	2.03e-04	160	32	3	58ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GRIK1 ANKRD34B NACC2	2.07e-04	161	32	3	b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Tac1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GRIK1 ANKRD34B NACC2	2.22e-04	165	32	3	d8df50f5a3b646e8ea13739fdc65ce6f39b4d4d2
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D175\|Adult / Lineage, Cell type, age group and donor	NEIL2 NRK AFAP1L1	2.38e-04	169	32	3	e1f0298236e4a1c59077c14f0dd29a78fac12648
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MACC1 LCORL OTOGL	2.43e-04	170	32	3	49fc45d8a5c3ad89d1649fa46d7a285891379392
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD34B NACC2 RYR1	2.47e-04	171	32	3	ff4ab7753320874600e5694f2681e672c144c294
ToppCell	(07)_Ionocytes-(2)_GFP_FOXI1\|(07)_Ionocytes / shred by cell type by condition	NFKBIZ MACC1 DSC2	2.51e-04	172	32	3	5776b638b845d054f6e884e7df0412477f48517d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD34B NACC2 RYR1	2.55e-04	173	32	3	61907116a1460bc157ba73b5edd108db7dd5de4b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD34B NACC2 RYR1	2.64e-04	175	32	3	11f49f00e000cbc137e3540a6d6805cde21d96e6
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD34B NACC2 RYR1	2.69e-04	176	32	3	95d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L3-6_PVALB_MFI2_(Chandelier_2)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD34B NACC2 RYR1	2.73e-04	177	32	3	4f88ea4cfcfa8a9af5a14ab6f6be3b2aa015852e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L3-6_PVALB_MFI2_(Chandelier_2)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD34B NACC2 RYR1	2.73e-04	177	32	3	4d67e24653caa318039870114849426ff2582e0c
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANKRD34B PLXNA1 NRK	2.73e-04	177	32	3	30f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GRIK2 LCORL STARD9	2.82e-04	179	32	3	327cc39161741ddbc4e8d45b9b3d30b3ce508929
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD34B NACC2 RYR1	2.82e-04	179	32	3	3b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD34B NACC2 RYR1	2.91e-04	181	32	3	153709b4dd3d81e09f251fa8765b58bed1932fda
ToppCell	Endothelial-B-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	GRIK1 STARD9 AFAP1L1	2.91e-04	181	32	3	4fe0215d08f03d4e24749d70fce01b7aa22906fd
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD34B NACC2 RYR1	2.91e-04	181	32	3	7704f236831cffe4f2a75d4c461eb88b4177e206
ToppCell	Hippocampus-Neuronal-Inhibitory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GRIK1 ANKRD34B NACC2	2.96e-04	182	32	3	b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D175\|Adult / Lineage, Cell type, age group and donor	STARD9 NRK AFAP1L1	2.96e-04	182	32	3	8b4a07ebd7a133a33ef333cfa29d12c4f3d4d9ac
ToppCell	HSPCs-Ery/Mk_prog.\|HSPCs / Lineage and Cell class	KANSL1L NFKBIZ PLEC	3.01e-04	183	32	3	59cfb02143b6b54dfca7560562e064948f0340ca
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK1 GRIK2 RNASET2	3.21e-04	187	32	3	85f1678338a47d91e296f0620d4887f057eb7e70
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD34B NACC2 RNASET2	3.31e-04	189	32	3	78cf414b98bcb19deb934409acddaad1cd51b67f
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLEKHG2 NEIL2 AFAP1L1	3.31e-04	189	32	3	0739baad9a7da511dd3d7249f84299aee88370a1
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	NFKBIZ BNIP3L NRK	3.36e-04	190	32	3	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NFKBIZ MACC1 GRIK2	3.36e-04	190	32	3	b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCell	LV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	NFKBIZ BNIP3L NRK	3.41e-04	191	32	3	d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	NFKBIZ BNIP3L STARD9	3.41e-04	191	32	3	70c067c54084bfb02c29bab085f4defd477194fb
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK1 GRIK2 RNASET2	3.46e-04	192	32	3	dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK1 GRIK2 RNASET2	3.52e-04	193	32	3	d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK1 GRIK2 RNASET2	3.52e-04	193	32	3	8b77625bf3c87d39767fb391d1beaca4ab02342b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK1 GRIK2 RNASET2	3.52e-04	193	32	3	010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK1 GRIK2 RNASET2	3.52e-04	193	32	3	3ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK1 GRIK2 RNASET2	3.52e-04	193	32	3	2189da4b727e25e62669d7b9257f06493be21a27
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NFKBIZ DSC2 OTOGL	3.62e-04	195	32	3	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NFKBIZ DSC2 OTOGL	3.62e-04	195	32	3	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PLEKHG2 PLEC RNASET2	3.73e-04	197	32	3	8c24ffcd417da42fa9bcbe6bd0325360e537303f
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NFKBIZ PLEKHG2 RNASET2	3.79e-04	198	32	3	acb84681569651447d684aa3960f0510d7ff17e8
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NFKBIZ PLEKHG2 DSC2	3.79e-04	198	32	3	d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-B3GAT2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRIK1 GRIK2 RNASET2	3.90e-04	200	32	3	858421b91f5207b7934b5c219752cb9322a3da31
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRIK1 GRIK2 RNASET2	3.90e-04	200	32	3	347a510755374c6a66acee326565dfc447993f18
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SCUBE3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ANKRD34B NACC2 RYR1	3.90e-04	200	32	3	2441a36d363b799a4692aa697f969cda056c2d60
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related-Oligodendrocyte/OPC\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	TNKS1BP1 PLEC MORC3	3.90e-04	200	32	3	4db894cfb80fd1f9e01133f345eefd78edd4bc43
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	TNKS1BP1 PLEC MORC3	3.90e-04	200	32	3	d46a19274c2836ce7494790ce513764dedcadc79
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal-BMP_responsible_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	NFKBIZ RYR1 RNASET2	3.90e-04	200	32	3	26251ed8c7fa7e87973d6f59bd398c88ad025395
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-LGR5--L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRIK1 GRIK2 ANKRD34B	3.90e-04	200	32	3	8c1d4fffa5abe89ee2ff84fed2dfa97c779bde04
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-LGR5-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRIK1 GRIK2 ANKRD34B	3.90e-04	200	32	3	1026b4ede4ea61d01ea942164b37a08c8c8234ff
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SCUBE3-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ANKRD34B NACC2 RYR1	3.90e-04	200	32	3	c7bca638229bd4fd2414171e73fa949e36a10a92
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	NFKBIZ RYR1 RNASET2	3.90e-04	200	32	3	fe22f7c97f4e37dfa7881d0f1d9245c1237d873b
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SCUBE3--L2-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ANKRD34B NACC2 RYR1	3.90e-04	200	32	3	d841dbe2297c3bf62f49bae5921662cd6a47e5c2
ToppCell	Influenza\|World / Disease, condition lineage and cell class	NFKBIZ PLEC NACC2	3.90e-04	200	32	3	df996c35907a1c9194b9e2ca30e81f520ca067f0
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-B3GAT2-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRIK1 GRIK2 RNASET2	3.90e-04	200	32	3	a7022762c1d8aedb7b3e9605873b1e68b9907b35
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-B3GAT2--L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRIK1 GRIK2 RNASET2	3.90e-04	200	32	3	2131c8e7fa054b79906eaf60536da892438b09cd
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-LGR5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRIK1 GRIK2 ANKRD34B	3.90e-04	200	32	3	72c9cd872074b60f62685a95eab83c41e609eb6e
Computational	Ion channels.	GRIK1 GRIK2 RYR1	2.79e-04	70	20	3	MODULE_316
Drug	5-nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime	GRIK1 GRIK2	1.91e-06	2	32	2	ctd:C084273
Drug	tetrabromobisphenol A	TEF NRK RYR1	1.22e-05	32	32	3	CID000006618
Disease	1-Methylhistidine measurement	ALMS1 OTOGL	1.53e-04	17	32	2	EFO_0021543
Disease	colorectal cancer, inflammatory bowel disease	GRIK2 ALMS1	1.93e-04	19	32	2	EFO_0003767, MONDO_0005575
Disease	Huntington disease, disease progression measurement	PRDM9 RNASET2	4.86e-04	30	32	2	EFO_0008336, MONDO_0007739
Disease	ocular hypertension, response to triamcinolone acetonide	GRIK1 OTOGL	1.30e-03	49	32	2	EFO_0006954, EFO_1001069

Protein segments in the cluster

Peptide	Gene	Start	Entry
NPHPCNPDSDVVENN	GRIK1	606	P39086
PLPQGQDCVVEKNNQ	ALMS1	2986	Q8TCU4
NVEDQDEGPECNPPI	DSC2	461	Q02487
GNQQCIEVPVDQDPD	ANKRD34B	331	A5PLL1
VPQECQDPVPEQDFE	KANSL1L	446	A0AUZ9
NPVVVPQSSPAEQCQ	NFKBIZ	241	Q9BYH8
CFQPEQVVDPIQTDP	MAP4	126	P27816
PQCQPQLSEEPEQCQ	NEIL2	316	Q969S2
PQNCDPNIPLVAQEL	LCORL	146	Q8N3X6
NCVNPENENAPEVPV	PLXNA1	1506	Q9UIW2
SNNPDPQFRNCEVPE	MORC3	436	Q14149
DPQNAPDVNYVVENP	GPS1	26	Q13098
QPENPCPGDQNQEQQ	PRDM9	426	Q9NQV7
NNNCEENEQSLPPPA	BNIP3L	16	O60238
CVQVEPPNGEPVAQF	MACC1	486	Q6ZN28
NVCDPAQPETFPVAQ	MAN2C1	221	Q9NTJ4
AQQQQPPCEQELSPL	CEP192	1016	Q8TEP8
NPHPCNPDSDVVENN	GRIK2	591	Q13002
NIEPPDQEPSQVENQ	RYR1	1051	P21817
PVHVPVVDPCNINQQ	OTOGL	656	Q3ZCN5
PEQELEQNQAPEQPE	NRK	546	Q7Z2Y5
PEQPEVQEQAAEPAQ	NRK	556	Q7Z2Y5
PIDPNCVEVDVNFNP	TEF	171	Q10587
GDQNAQVCQTNPEPP	STARD9	3121	Q9P2P6
NCPPPQVAVQQVDLC	ERVK-9	656	P63128
PDNNQQPKGIPACEQ	AKAP17A	551	Q02040
NSVPEQPLPVNCVSE	AFAP1L1	726	Q8TED9
QDQQLQNCTEPGEQP	RNASET2	206	O00584
QEQPAAPDQPCVLFA	TNKS1BP1	621	Q9C0C2
VCFLVPPPNQEAQEA	PLEC	991	Q15149
DTCAEPQCQPQEAIP	ZNF333	271	Q96JL9
PQCQPQEAIPSQDTF	ZNF333	276	Q96JL9
AQPQPSPCLPQEQAE	PLEKHG2	851	Q9H7P9
QPCQEVPDISQPCQD	PPIP5K1	1256	Q6PFW1
EPQSPCNQLQPAAAA	NACC2	141	Q96BF6