Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	secretory granule	SERPINA3 FCAR SPATA31A1 SPATA31A3 ANPEP GUSB SPATA31A7 CAT SPATA31A6 SPATA31A5	1.43e-04	1014	51	10	GO:0030141
GeneOntologyCellularComponent	acrosomal vesicle	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	1.44e-04	206	51	5	GO:0001669
GeneOntologyCellularComponent	secretory vesicle	SERPINA3 FCAR SPATA31A1 SPATA31A3 ANPEP GUSB SPATA31A7 CAT SPATA31A6 SPATA31A5	7.41e-04	1246	51	10	GO:0099503
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	2.04e-08	12	49	4	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	2.04e-08	12	49	4	IPR027970
Domain	Dullard_phosphatase	CTDSPL2 CTDSP1	6.71e-05	5	49	2	IPR011948
Domain	CPDc	CTDSPL2 CTDSP1	1.87e-04	8	49	2	SM00577
Domain	FCP1	CTDSPL2 CTDSP1	1.87e-04	8	49	2	PS50969
Domain	FCP1_dom	CTDSPL2 CTDSP1	2.40e-04	9	49	2	IPR004274
Domain	NIF	CTDSPL2 CTDSP1	2.40e-04	9	49	2	PF03031
Domain	WD40_repeat_CS	PIK3R4 NWD2 SEC31B	9.11e-03	164	49	3	IPR019775
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	3.67e-14	6	52	5	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	3.67e-14	6	52	5	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	2.55e-10	24	52	5	32212159
Pubmed	Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma.	IGF1R TNFSF10	2.19e-06	2	52	2	20417200
Pubmed	TRAIL stimulates proliferation of vascular smooth muscle cells via activation of NF-kappaB and induction of insulin-like growth factor-1 receptor.	IGF1R TNFSF10	2.19e-06	2	52	2	18178561
Pubmed	Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.	IGF1R ANPEP	6.57e-06	3	52	2	19330903
Pubmed	HSPA1L Enhances Cancer Stem Cell-Like Properties by Activating IGF1Rβ and Regulating β-Catenin Transcription.	IGF1R HSPA1L	6.57e-06	3	52	2	32971893
Pubmed	Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL.	IGF1R TNFSF10	1.31e-05	4	52	2	21538027
Pubmed	Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.	SERPINA3 ANPEP GUSB	1.38e-05	31	52	3	25645918
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CEP350 PIK3R4 ACAD8 RTL10 ADGRB3 CTDSP1 TAF1 MORC3 SNRNP70 SEC31B	1.76e-05	1285	52	10	35914814
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	PIK3R4 IFIH1 IGF1R KIAA0825 BEND4 SPATA31A6	9.64e-05	497	52	6	36774506
Pubmed	Genetic analysis of nonhistone chromosomal protein inheritance in recombinant inbred mouse strains using two-dimensional electrophoresis.	ANPEP GUSB	1.20e-04	11	52	2	2383242
Pubmed	Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13.	IGF1R CAT	1.20e-04	11	52	2	8020965
Pubmed	A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility.	TNFSF10 ADGRB3	2.27e-04	15	52	2	14996723
Pubmed	Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants.	IGF1R CAT	3.30e-04	18	52	2	19584075
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	NWD2 FAM193A FAM120C ADGRB3 CAT	7.13e-04	475	52	5	31040226
Pubmed	Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.	SUPT20HL1 TAF1	1.12e-03	33	52	2	11564863
Pubmed	Inceptor counteracts insulin signalling in β-cells to control glycaemia.	IGF1R ANPEP	1.19e-03	34	52	2	33505018
Pubmed	A molecular genetic linkage map of mouse chromosome 7.	IGF1R SNRNP70	1.41e-03	37	52	2	1981054
Pubmed	Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly.	CEP350 FAM193A	1.49e-03	38	52	2	36674791
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	3.51e-05	8	52	2	chr9q12
Cytoband	9p13.1	SPATA31A1 SPATA31A3	3.42e-04	24	52	2	9p13.1
GeneFamily	CTD family phosphatases	CTDSPL2 CTDSP1	5.98e-05	8	27	2	1041
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	IGF1R FCAR ANPEP TNFSF10	2.62e-03	394	27	4	471
Drug	N-hydroxy-1-naphthylamine	GUSB CAT	3.82e-06	2	45	2	CID000011828
Drug	tectorigenin	IGF1R GUSB CAT	9.36e-06	21	45	3	CID005281811
Disease	skin microbiome measurement	ANO4 ADGRB3 NPAS3	3.32e-05	39	47	3	EFO_0801228
Disease	fasting blood insulin measurement	ACAD8 MSMO1 MAP4K5	1.84e-04	69	47	3	EFO_0004466
Disease	Graves' disease (is_marker_for)	IGF1R CAT	2.57e-04	15	47	2	DOID:12361 (is_marker_for)
Disease	Major Depressive Disorder	ANPEP NPAS3 CAT HSPA1L	6.06e-04	243	47	4	C1269683
Disease	Unipolar Depression	ANPEP NPAS3 CAT HSPA1L	7.69e-04	259	47	4	C0041696
Disease	hyperthyroidism (biomarker_via_orthology)	IGF1R CAT	9.14e-04	28	47	2	DOID:7998 (biomarker_via_orthology)
Disease	IgA glomerulonephritis (is_implicated_in)	IGF1R FCAR	1.05e-03	30	47	2	DOID:2986 (is_implicated_in)
Disease	diet measurement	BRINP3 NWD2 RPAP1 MAP4K5 ADGRB3 NPAS3 BEND4	1.28e-03	1049	47	7	EFO_0008111
Disease	systolic blood pressure, body mass index	POLR1F ADGRB3	1.35e-03	34	47	2	EFO_0004340, EFO_0006335
Disease	lysophosphatidylcholine 20:3 measurement	MAP4K5 ZNF91	1.86e-03	40	47	2	EFO_0010362
Disease	ulcerative colitis (is_marker_for)	BRINP3 IGF1R	1.86e-03	40	47	2	DOID:8577 (is_marker_for)
Disease	diabetic retinopathy (biomarker_via_orthology)	IGF1R CAT	2.35e-03	45	47	2	DOID:8947 (biomarker_via_orthology)
Disease	severe acute respiratory syndrome (is_marker_for)	SERPINA3 ANPEP	2.56e-03	47	47	2	DOID:2945 (is_marker_for)
Disease	Influenza	IFIH1 TNFSF10	3.13e-03	52	47	2	C0021400

Protein segments in the cluster

Peptide	Gene	Start	Entry
SESWFMPVNENSFPD	BRINP3	581	Q76B58
MPVNENSFPDWERTK	BRINP3	586	Q76B58
MPDWEQSAESLQPVQ	CAGE1	286	Q8TC20
NGIPIESWFMDKNDN	CTDSPL2	416	Q05D32
NPQTHLKDPDMVWDF	CAT	171	P04040
APNMAEWDQKELFPV	ACAD8	61	Q9UKU7
KWEMPFDPQDTHQSR	SERPINA3	216	P01011
NTSSMENPAPNKNPW	ADGRB3	1456	O60242
SNPDWWMPSEEQINK	BEND4	471	Q6ZU67
WMPSEEQINKVFSDA	BEND4	476	Q6ZU67
YANAHPWQQMDKASP	RTL10	21	Q7L3V2
DPNWNVTEFHTTPKM	ANPEP	261	P15144
SFPQWEKDYNLQPMN	ANO4	691	Q32M45
MNDKNWNPGTFLPDT	FAM193A	536	P78312
MEQASFDRQAPDQPW	NWD2	801	Q9ULI1
FDPDWNPANDEQAMA	RAD54L	591	Q92698
ENQSSKAPEPLFMWT	ADAMTS19	906	Q8TE59
ENPLQEPFKNAWNYM	MSMO1	26	Q15800
QVWQDSHMFPEEEQP	KIAA0825	466	Q8IV33
SNSWNMVDVDLPPNK	IGF1R	546	P08069
ADVAEPSWSQQMCQP	FCAR	261	P24071
MDQLPEKWYCSNNPD	MORC3	426	Q14149
FSQEEIKNMWAAFPP	MYLPF	131	Q96A32
PDNAVPVASWFDNMS	CTDSP1	216	Q9GZU7
NDPVVQADMKLWPFQ	HSPA1L	81	P34931
NPTRNEWDKIPSMNQ	KLHL21	486	Q9UJP4
DMPVPSSFNDISQDW	GUSB	76	P08236
FSEDPMLQNSPFANW	FAM120C	481	Q9NX05
PNLEKEVWGMENNSS	IFIH1	231	Q9BYX4
PDGKVWQEAEFQNMS	CEP350	351	Q5VT06
SSDPNFMLQWNPFVD	MAP4K5	361	Q9Y4K4
LKMWDPHNDPNAQGD	SNRNP70	86	P08621
NPESSLMWKPQEQAV	SENP2	171	Q9HC62
QAWDTKPSIMQSFND	SUPT20HL1	346	Q3ZLR7
DAEQDTTNPKPFWNM	SPATA31A6	371	Q5VVP1
MSQPEVKDPWNLSND	TAF1	556	P21675
DNIKNPMYNWSPDIQ	SLC17A1	66	Q14916
DAEQDTTNPKPFWNM	SPATA31A7	371	Q8IWB4
QSAMPWDQDPEQSTG	NANOGNB	36	Q7Z5D8
LKMRDFANQGDPPWN	NPAS3	101	Q8IXF0
SAFFDELVPQNMTPW	SEC31B	541	Q9NQW1
PPLQTMKANQNSEWE	PMIS2	106	A0A1W2PS18
NEEWKSMFGSLDPPN	PIK3R4	856	Q99570
DAEQDTTNPKPFWNM	SPATA31A3	371	Q5VYP0
FLPSWVRNSNPDEQM	TCEANC	316	Q8N8B7
DAEQDTTNPKPFWNM	SPATA31A1	371	Q5TZJ5
DAEQDTTNPKPFWNM	SPATA31A5	371	Q5VU36
PASWSQSPQNQEMRK	STOX1	881	Q6ZVD7
PKHQWGEEEPNSQME	SLU7	216	O95391
QFMDSPEWESLQPSE	POPDC2	181	Q9HBU9
PKPEQLSAEQWQTME	POLR1F	156	Q3B726
QQPSSCPEDWLQDMQ	RPAP1	811	Q9BWH6
PQDFWPEQSMEDSFQ	ZNF91	91	Q05481
DPNDEESMNSPCWQV	TNFSF10	66	P50591
DKNPFNMEVLVDAWP	GLYATL2	36	Q8WU03