Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	arylsulfatase activity	ARSH STS ARSL	1.46e-05	14	70	3	GO:0004065
GeneOntologyMolecularFunction	sulfuric ester hydrolase activity	ARSH STS ARSL	2.71e-05	17	70	3	GO:0008484
Domain	Sulfatase_CS	ARSH STS ARSL	2.50e-05	16	68	3	IPR024607
Domain	SULFATASE_1	ARSH STS ARSL	3.03e-05	17	68	3	PS00523
Domain	SULFATASE_2	ARSH STS ARSL	3.03e-05	17	68	3	PS00149
Domain	Sulfatase	ARSH STS ARSL	3.62e-05	18	68	3	PF00884
Domain	Sulfatase_N	ARSH STS ARSL	3.62e-05	18	68	3	IPR000917
Domain	Alkaline_phosphatase_core	ARSH STS ARSL	1.93e-04	31	68	3	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ARSH STS ARSL	1.93e-04	31	68	3	IPR017849
Domain	-	ARSH STS ARSL	1.93e-04	31	68	3	3.40.720.10
Domain	Fol_N	FCGBP SLIT1	7.03e-04	11	68	2	IPR003645
Domain	FOLN	FCGBP SLIT1	7.03e-04	11	68	2	SM00274
Domain	TSP_1	ADGRB1 ADAMTS15 ADAMTS5	1.57e-03	63	68	3	PF00090
Domain	TSP1	ADGRB1 ADAMTS15 ADAMTS5	1.72e-03	65	68	3	SM00209
Domain	TSP1_rpt	ADGRB1 ADAMTS15 ADAMTS5	1.72e-03	65	68	3	IPR000884
Domain	TSP1	ADGRB1 ADAMTS15 ADAMTS5	1.72e-03	65	68	3	PS50092
Domain	Iontro_rcpt	GRIA1 GRIN3B	1.92e-03	18	68	2	IPR001320
Domain	Lig_chan-Glu_bd	GRIA1 GRIN3B	1.92e-03	18	68	2	PF10613
Domain	Iono_rcpt_met	GRIA1 GRIN3B	1.92e-03	18	68	2	IPR001508
Domain	Glu/Gly-bd	GRIA1 GRIN3B	1.92e-03	18	68	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIA1 GRIN3B	1.92e-03	18	68	2	SM00918
Domain	Lig_chan	GRIA1 GRIN3B	1.92e-03	18	68	2	PF00060
Domain	PBPe	GRIA1 GRIN3B	1.92e-03	18	68	2	SM00079
Domain	ADAM_spacer1	ADAMTS15 ADAMTS5	3.15e-03	23	68	2	IPR010294
Domain	ADAM_spacer1	ADAMTS15 ADAMTS5	3.15e-03	23	68	2	PF05986
Domain	MetalloPept_cat_dom	MMP28 ADAMTS15 ADAMTS5	3.22e-03	81	68	3	IPR024079
Domain	-	MMP28 ADAMTS15 ADAMTS5	3.22e-03	81	68	3	3.40.390.10
Domain	Peptidase_M12B_ADAM-TS	ADAMTS15 ADAMTS5	3.42e-03	24	68	2	IPR013273
Domain	ACR	ADAMTS15 ADAMTS5	4.32e-03	27	68	2	SM00608
Domain	ADAM_Cys-rich	ADAMTS15 ADAMTS5	4.32e-03	27	68	2	IPR006586
Domain	ZINC_PROTEASE	MMP28 ADAMTS15 ADAMTS5	5.49e-03	98	68	3	PS00142
Domain	LRRCT	SLIT1 LGI4	6.04e-03	32	68	2	PF01463
Domain	Peptidase_M12B_N	ADAMTS15 ADAMTS5	8.87e-03	39	68	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS15 ADAMTS5	8.87e-03	39	68	2	PF01562
Domain	Peripla_BP_I	GRIA1 GRIN3B	8.87e-03	39	68	2	IPR028082
Domain	DISINTEGRIN_1	ADAMTS15 ADAMTS5	9.32e-03	40	68	2	PS00427
Domain	Reprolysin	ADAMTS15 ADAMTS5	9.32e-03	40	68	2	PF01421
Domain	ADAM_MEPRO	ADAMTS15 ADAMTS5	9.32e-03	40	68	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS15 ADAMTS5	9.32e-03	40	68	2	PS50214
Domain	Peptidase_M12B	ADAMTS15 ADAMTS5	9.32e-03	40	68	2	IPR001590
Domain	CYSTEINE_SWITCH	MMP28 ADAMTS15	9.77e-03	41	68	2	PS00546
Domain	Disintegrin_dom	ADAMTS15 ADAMTS5	9.77e-03	41	68	2	IPR001762
Domain	Pept_M10_metallopeptidase	MMP28 ADAMTS15	1.07e-02	43	68	2	IPR001818
Pathway	REACTOME_GLYCOSPHINGOLIPID_CATABOLISM	ARSH NEU1 STS ARSL	1.43e-05	39	54	4	M48042
Pathway	REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES	ARSH STS ARSL	1.48e-05	13	54	3	M663
Pathway	REACTOME_GLYCOSPHINGOLIPID_METABOLISM	ARSH NEU1 STS ARSL	7.00e-05	58	54	4	M576
Pubmed	Identification of genes showing differential expression in anorexia mutant mouse.	TYRO3 GRIA1	4.59e-06	2	75	2	12802202
Pubmed	Cell surface molecules involved in infection mediated by lymphocytic choriomeningitis virus glycoprotein.	TYRO3 CLEC4G	2.75e-05	4	75	2	22673088
Pubmed	Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanase.	ADAMTS15 ADAMTS5	2.75e-05	4	75	2	24220035
Pubmed	Cell-specific and developmental expression of lectican-cleaving proteases in mouse hippocampus and neocortex.	ADAMTS15 ADAMTS5	4.57e-05	5	75	2	25349050
Pubmed	Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry.	TYRO3 CLEC4G	4.57e-05	5	75	2	22156524
Pubmed	A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins.	CLEC4G POMGNT1 FUT4	5.02e-05	33	75	3	23118208
Pubmed	Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system.	SLIT1 FUT4	6.84e-05	6	75	2	11804570
Pubmed	The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican.	ADAMTS15 ADAMTS5	9.57e-05	7	75	2	15599946
Pubmed	Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion.	ADAMTS15 ADAMTS5	1.27e-04	8	75	2	23233679
Pubmed	Specific assembly with the NMDA receptor 3B subunit controls surface expression and calcium permeability of NMDA receptors.	GRIA1 GRIN3B	1.27e-04	8	75	2	14602821
Pubmed	Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits.	SLIT1 FUT4	1.64e-04	9	75	2	10864955
Pubmed	Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors.	IGSF8 CORIN	2.49e-04	11	75	2	25775569
Pubmed	Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.	ADAMTS15 ADAMTS5	2.49e-04	11	75	2	29337306
Pubmed	DSCAM promotes axon fasciculation and growth in the developing optic pathway.	SLIT1 FUT4	4.11e-04	14	75	2	28137836
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADGRB1 ADAMTS15 ADAMTS5	5.82e-04	75	75	3	20637190
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	SORT1 GRIA1 GRIN3B	7.28e-04	81	75	3	22723691
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	GPR146 CRLS1 NEU1 MYO1E PHLDA1 ADGRB1 LTB4R2	7.69e-04	697	75	7	28298427
Pubmed	ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.	ADAMTS15 ADAMTS5	8.50e-04	20	75	2	19922873
Pubmed	Stable association between G alpha(q) and phospholipase C beta 1 in living cells.	MCHR1 AVPR1B LTB4R2	1.16e-03	95	75	3	16754659
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIA1 GRIN3B	1.23e-03	24	75	2	35746896
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	LUC7L ZSWIM8 ERI3 SLIT1 FRS3 POMGNT1	1.34e-03	560	75	6	21653829
Pubmed	Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.	SORT1 MTNR1B	1.44e-03	26	75	2	19060910
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	SORT1 EPHX1 IBA57 RBM15 SCNM1 AVPR1B POMGNT1 HES3	1.69e-03	1031	75	8	16710414
Pubmed	Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.	SORT1 EPHX1 ILF3 MARCHF4	1.70e-03	235	75	4	32614325
Pubmed	Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.	IGSF8 TYRO3 SWSAP1	1.81e-03	111	75	3	21163940
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	ARHGAP24 ILF3 SLIT1 MTNR1B C11orf21 GRIA1 SLC28A3	1.87e-03	814	75	7	23251661
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	LUC7L RBM15 NEU1 ILF3 L3MBTL2	2.10e-03	417	75	5	36537216
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	IGSF8 EPHX1 CRLF3 SLIT1 HPS6	2.14e-03	419	75	5	33001583
Cytoband	19p13.2	ILF3 PEX11G CLEC4G SWSAP1	5.55e-04	229	75	4	19p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	TMPRSS9 ILF3 PEX11G CLEC4G GRIN3B SWSAP1	1.96e-03	797	75	6	chr19p13
GeneFamily	Sulfatases	ARSH STS ARSL	1.15e-05	18	45	3	410
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS15 ADAMTS5	1.01e-03	19	45	2	50
GeneFamily	Proteases, serine	TMPRSS9 CORIN	1.07e-02	63	45	2	738
Disease	interleukin-36 alpha measurement	NEU1 SARM1	2.15e-04	9	73	2	EFO_0021851
Disease	non-receptor tyrosine-protein kinase TYK2 measurement	NEU1 SARM1	2.68e-04	10	73	2	EFO_0008251
Disease	Pre-Eclampsia	EPHX1 CORIN	7.08e-04	16	73	2	C0032914
Disease	bipolar disorder, sex interaction measurement	SLIT1 ADGRB1	9.00e-04	18	73	2	EFO_0008343, MONDO_0004985
Disease	pre-eclampsia (is_implicated_in)	EPHX1 CORIN	1.75e-03	25	73	2	DOID:10591 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RPSEGLPSAGWGRWR	nan	121	A8MZ25
LPSAGWGRWRGRPIH	nan	126	A8MZ25
GRGRPWEGGLVSWPP	ERI3	11	O43414
WGGLGSWRSRLVGEP	C1orf167	391	Q5SNV9
WVPGLPLWTRDQGPR	C1orf167	1271	Q5SNV9
GGWEGGIRVPGIFRW	ARSH	351	Q5FYA8
RPWAGWSGGRGIHRE	CCDC187	1021	A0A096LP49
GGWEGGIRVPGIFRW	ARSL	381	P51690
LGPWSWRGCRTVPLD	ADGRB1	901	O14514
PAGGSGPQTWWRRRR	ADAMTS5	246	Q9UNA0
SGRAVLGPNGRWVPW	AFDN-DT	101	Q9Y6Z5
LGPNGRWVPWAVLGS	AFDN-DT	106	Q9Y6Z5
RWVPWAVLGSVRTGG	AFDN-DT	111	Q9Y6Z5
TPGRGGPVWRWRLRA	IBA57	11	Q5T440
PARSTFWGPQPWEGR	C16orf54	146	Q6UWD8
PWEGRPPATGLVSWA	C16orf54	156	Q6UWD8
LPRPWAPGGTGWRES	DDN	401	O94850
DDRPPARWVAGSWGP	ADAMTS15	836	Q8TE58
LAVRWNSPGEGGPWV	PRODH2	331	Q9UF12
ATPTTRLWVGGLGPW	RBM15	451	Q96T37
RLWVGGLGPWVPLAA	RBM15	456	Q96T37
SSVSGPRHWWPPRGI	SPINK14	21	Q6IE38
GFKDPGATRPGVWRW	KRBA1	586	A5PL33
GATRPGVWRWLPEGS	KRBA1	591	A5PL33
SWESGRSERGPPDWR	LUC7L	336	Q9NQ29
WSPLIHPVGWSRRVG	L3MBTL2	371	Q969R5
GRKGRAVPGWASWPA	FUT4	41	P22083
SRPVGVLLWWEPFGG	FUT4	186	P22083
WAVRPGWSGAGSARP	MTNR1B	16	P49286
WVFPRGLSWGPEGLI	PNMA6E	591	A0A0J9YXQ4
ARGDGRQEWSPWSVP	CRLF3	251	Q8IUI8
ESPGLGLRVWRPWGS	HES3	166	Q5TGS1
GLRVWRPWGSPGDDL	HES3	171	Q5TGS1
RWSLGWPGSRGRDVF	LINC00336	11	Q6ZUF6
WVKSIRRVIWGPFGG	ARHGAP24	116	Q8N264
RWGRFLLQRGSWTGP	IGLL1	66	P15814
VRGGPPGLRLAASWW	IGSF8	466	Q969P0
TLPLEDGWWGPGTRS	EPHX1	26	P07099
GTLAPSIPIWGGSWR	FCGBP	1831	Q9Y6R7
TGGLWRGAGWRLSPE	FRS3	291	O43559
LCTRVPTWGPLRGWP	ILF3	236	Q12906
RILGGRTSRPGRWPW	CORIN	801	Q9Y5Q5
GWAGWRGPREVVGRE	MARCHF4	86	Q9P2E8
GGRRWRLPQPAWVEG	MCHR1	41	Q99705
SKWPSGTPGGRLRWA	DENND4B	861	O75064
PPGRAAGSGWAWRPV	KLHDC9	6	Q8NEP7
IGASSGPVAWGPWRR	KLF15	96	Q9UIH9
GPVAWGPWRRAAAPV	KLF15	101	Q9UIH9
GPPSSRWALWSVGGE	GPR146	86	Q96CH1
SPRSLSGRIVGGVWW	GRIA1	606	P42261
AEVWGAGVGPGWRPL	HPS6	101	Q86YV9
LRSSGWIPDGRGRWV	SCNM1	196	Q9BWG6
GVPGWRRPTTLYPWR	CDH15	21	P55291
WGALRGAAWAPGTRP	CRLS1	11	Q9UJA2
GRCWRFRGPKPVWGL	MMP28	391	Q9H239
DPRGAPAWATVGSWR	GRIN3B	376	O60391
AGALLRVWGFWPTGV	HSCB	6	Q8IWL3
RVWGFWPTGVPRRRP	HSCB	11	Q8IWL3
GRFWSGWRRGLGVRP	RPUSD3	16	Q6P087
PLPRWSGPIGVSWGL	SORT1	46	Q99523
SWGPAWGERGHFRIV	TINAGL1	426	Q9GZM7
RLWGGSQLWARPSPG	LGI4	286	Q8N135
PGNGFVVWSLAGWRP	LTB4R2	36	Q9NPC1
GPALGWRDTWAFVGR	POMGNT1	201	Q8WZA1
WRDTWAFVGRKGGPV	POMGNT1	206	Q8WZA1
PDRRWGPRILGFWGG	NEU1	11	Q99519
GPRILGFWGGCRVWV	NEU1	16	Q99519
NWEGGIRVPGILRWP	STS	371	P08842
PDAWIGLWGVLRGTP	MTRES1	16	Q9P0P8
PGGLGPRTEWWVTFR	SWSAP1	186	Q6NVH7
PTRVYWRPVLWGIGL	SLC28A3	221	Q9HAS3
FFPWEAPDRPIGTWG	PROB1	501	E7EW31
RSPWWVRVTSTGRPG	ACY1	191	Q03154
GSSEEVPGGPWGRWV	CLEC4G	11	Q6UXB4
DRWTGTPGWPSRDQE	C11orf21	36	Q9P2W6
RGVLWAGRFPPWLVG	PEX11G	201	Q96HA9
GGGWRTWDRPSPSTL	AVPR1B	241	P47901
PWWAAGGRGPREVSP	SARM1	41	Q6SZW1
FPLGVTRGWGRWPIQ	PHLDA1	26	Q8WV24
RIVGGSAAGRGEWPW	TMPRSS9	826	Q7Z410
APGPRWRSWLLGGIV	PIGZ	206	Q86VD9
RRPLRGGWAPTSWGR	ZSWIM8	1161	A7E2V4
ETPPGDWLFGGVRWG	ZNF746	366	Q6NUN9
GVRWGWNFRCKPPVG	ZNF746	376	Q6NUN9
GWGSSAGPVRPELWL	SLIT1	6	O75093
LPCLVRGGWPWTRPD	WWC2-AS2	51	Q96NR7
RGGWPWTRPDSSPFR	WWC2-AS2	56	Q96NR7
EGVWEPGSWPERPRG	ZNF71	36	Q9NQZ8
IVWWRGTTKIGGPAP	TYRO3	171	Q06418
ARGGPSWWPPSGVVR	nan	96	Q6ZSA8
GSLWQEGAGWIPLPR	SLC30A2	21	Q9BRI3
IKEDPSGWWTGRLRG	MYO1E	1081	Q12965