Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	GFI1B ZNF431 ZBTB45 ZNF20 REST ZNF33A ZNF98 ZNF257 ZNF714 ZBTB25 ZNF665 ZNF846 ZNF280C	1.02e-07	1412	32	13	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	GFI1B ZNF431 ZBTB45 ZNF20 REST ZNF33A ZNF98 ZNF257 ZNF714 ZBTB25 ZNF665 ZNF846 ZNF280C	1.49e-07	1459	32	13	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	GFI1B ZNF431 ZBTB45 REST ZNF33A ZNF98 ZNF257 ZNF714 ZBTB25 ZNF665 ZNF280C	2.01e-06	1244	32	11	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	GFI1B ZNF431 ZBTB45 REST ZNF33A ZNF98 ZNF257 ZNF714 ZBTB25 ZNF665 ZNF280C	2.47e-06	1271	32	11	GO:0000987
GeneOntologyMolecularFunction	dynein complex binding	CFAP100 DCTN6	9.16e-04	28	32	2	GO:0070840
Domain	ZINC_FINGER_C2H2_2	ZNF462 GFI1B ZNF431 ZBTB45 ZNF20 REST ZNF33A ZNF98 ZNF257 ZNF714 ZBTB25 ZNF665 ZNF846 ZNF280C	9.40e-12	775	32	14	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF462 GFI1B ZNF431 ZBTB45 ZNF20 REST ZNF33A ZNF98 ZNF257 ZNF714 ZBTB25 ZNF665 ZNF846 ZNF280C	9.73e-12	777	32	14	PS00028
Domain	Znf_C2H2-like	ZNF462 GFI1B ZNF431 ZBTB45 ZNF20 REST ZNF33A ZNF98 ZNF257 ZNF714 ZBTB25 ZNF665 ZNF846 ZNF280C	1.34e-11	796	32	14	IPR015880
Domain	Znf_C2H2	ZNF462 GFI1B ZNF431 ZBTB45 ZNF20 REST ZNF33A ZNF98 ZNF257 ZNF714 ZBTB25 ZNF665 ZNF846 ZNF280C	1.56e-11	805	32	14	IPR007087
Domain	ZnF_C2H2	ZNF462 GFI1B ZNF431 ZBTB45 ZNF20 REST ZNF33A ZNF98 ZNF257 ZNF714 ZBTB25 ZNF665 ZNF846 ZNF280C	1.64e-11	808	32	14	SM00355
Domain	-	ZNF462 GFI1B ZNF431 ZBTB45 ZNF20 REST ZNF33A ZNF98 ZNF257 ZNF714 ZBTB25 ZNF665 ZNF846	3.18e-11	679	32	13	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF462 GFI1B ZNF431 ZBTB45 ZNF20 REST ZNF33A ZNF98 ZNF257 ZNF714 ZBTB25 ZNF665 ZNF846	4.17e-11	694	32	13	IPR013087
Domain	zf-C2H2	ZNF462 GFI1B ZNF431 ZBTB45 ZNF20 REST ZNF33A ZNF98 ZNF257 ZNF714 ZNF665 ZNF846	7.07e-10	693	32	12	PF00096
Domain	KRAB	ZNF431 ZNF20 ZNF33A ZNF98 ZNF257 ZNF714 ZNF846	2.00e-06	358	32	7	PS50805
Domain	KRAB	ZNF431 ZNF20 ZNF33A ZNF98 ZNF257 ZNF714 ZNF846	2.44e-06	369	32	7	SM00349
Domain	KRAB	ZNF431 ZNF20 ZNF33A ZNF98 ZNF257 ZNF714 ZNF846	2.48e-06	370	32	7	IPR001909
Domain	zf-C2H2_6	GFI1B ZNF431 ZNF20 ZNF98 ZNF714 ZNF846	1.35e-05	314	32	6	PF13912
Domain	KRAB	ZNF431 ZNF20 ZNF33A ZNF98 ZNF257 ZNF846	2.83e-05	358	32	6	PF01352
Domain	hEGF	FAT4 MEGF10	1.05e-03	28	32	2	PF12661
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF462 FHDC1 FANCM KHDC4 ZNF665 MSL2	5.22e-06	493	32	6	15368895
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF20 ZNF33A ZNF98 ZNF257	2.28e-05	181	32	4	37372979
Pubmed	Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.	ZNF462 REST ZNF280C	4.39e-05	74	32	3	29795351
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF462 GFI1B JADE1 REST ZNF665 ZNF280C	8.35e-05	808	32	6	20412781
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	ZNF462 FAT4 NEB SPAG17 ZNF665	9.92e-05	513	32	5	25798074
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZNF462 JADE1 MEGF10	1.32e-04	107	32	3	11347906
Pubmed	mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.	REST FANCM	2.05e-04	23	32	2	22017875
Pubmed	Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.	ZNF462 SPAG17	5.35e-04	37	32	2	19266077
Pubmed	Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.	KARS1 ZNF33A	6.90e-04	42	32	2	7584044
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF431 ZNF98 ZNF257 ZNF714	1.61e-06	122	32	4	chr19p12
Cytoband	19p12	ZNF431 ZNF98 ZNF714	3.47e-05	90	32	3	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr4q28	FAT4 JADE1	1.47e-03	81	32	2	chr4q28
Cytoband	19p13.2	ZNF20 ZNF846	1.11e-02	229	32	2	19p13.2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF462 GFI1B ZNF431 ZBTB45 ZNF20 ZNF33A ZNF98 ZNF257 ZNF714 ZBTB25 ZNF665 ZNF846	2.45e-11	718	24	12	28
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB45 ZBTB25	1.35e-02	134	24	2	861
Disease	Myopathy	AMPD1 MEGF10	4.27e-04	30	30	2	C0026848
Disease	lobe attachment	CRYBG1 FAT4 TNFRSF11B	1.20e-03	207	30	3	EFO_0007667
Disease	basophil count, eosinophil count	GFI1B CYP8B1 TNFRSF11B	1.86e-03	241	30	3	EFO_0004842, EFO_0005090
Disease	Nonsyndromic genetic hearing loss	KARS1 REST	2.72e-03	76	30	2	cv:C5680182

Protein segments in the cluster

Peptide	Gene	Start	Entry
YKLTTMKKVSDGHFH	FAT4	4046	Q6V0I7
SKHSGHMFSSKSPKP	AMPD1	516	P23109
HKQKGKESSMPAVTY	MEGF10	881	Q96KG7
PTTHMNGYSHLGKKK	FHDC1	81	Q9C0D6
YHFKSKHPTCPNKTM	REST	406	Q13127
TIMNHPTHKSLKAAY	NMT1	406	P30419
SDMKKHTYIHTGEKP	GFI1B	261	Q5VTD9
SKSSGPMYLHKSCHS	FANCM	1391	Q8IYD8
HHFMPGSPTKTVYKK	MSL2	441	Q9HCI7
KNGKLVMPHSSAHKT	HLA-DMB	151	P28068
HQKMTYSSKVSAKHT	CFAP100	86	Q494V2
GSHDYPAKKMKTTEK	KHDC4	546	Q7Z7F0
TSHSSLKSPSHMEKY	CRYBG1	911	Q9Y4K1
LPNYHHLKKTMKGSS	DCTN6	171	O00399
KTGKKIHHYTMPWGS	CYP8B1	421	Q9UNU6
MVKHITGSYKVTYHP	KARS1	361	Q15046
KQMGTSLVHSLKKPH	JADE1	581	Q6IE81
KGKSHKSQSSMAHKG	SPAG17	1356	Q6Q759
KSQLLEHMYTHKGKS	ZBTB25	361	P24278
LTTHMAVHTGDKPYK	ZNF665	641	Q9H7R5
TTHKMIHTGEKPYKC	ZNF431	416	Q8TF32
TLKGLMHALKHSKTY	TNFRSF11B	341	O00300
MHALKHSKTYHFPKT	TNFRSF11B	346	O00300
TTHKMIHTGEKPYKC	ZNF714	356	Q96N38
SSIQYHKMTHTGEKP	ZNF20	296	P17024
PHSFYKKSHAEGKMP	ZNF846	156	Q147U1
KNYTKHMFIHSGEKP	ZBTB45	416	Q96K62
KSTLSKPHGVSMKHY	ZNF33A	286	Q06730
TTHKMIHTGEKPYKC	ZNF98	506	A6NK75
HKMIHTGEKLYKPES	ZNF98	536	A6NK75
SFSKKGIVSHYMKRH	ZNF462	1776	Q96JM2
MKNTSYVLKHPSTSK	ZNF280C	166	Q8ND82
LTRHKMTHTGEKPYK	ZNF257	216	Q9Y2Q1
TPHISHSKDMGKLYS	NEB	4441	P20929