Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF267 ZNF12 ZNF677 ZNF480 NR2C1 ZNF431 ZSCAN16 ZNF660 ZNF391 ZNF714 ZNF646 ZNF662	3.79e-06	1459	35	12	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF267 ZNF12 ZNF677 ZNF480 NR2C1 ZNF431 ZSCAN16 ZNF660 ZNF714 ZNF646 ZNF662	5.46e-06	1244	35	11	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF267 ZNF12 ZNF677 ZNF480 NR2C1 ZNF431 ZSCAN16 ZNF660 ZNF714 ZNF646 ZNF662	6.70e-06	1271	35	11	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF267 ZNF12 ZNF677 ZNF480 NR2C1 ZNF431 ZSCAN16 ZNF391 ZNF714 ZNF646	1.08e-04	1412	35	10	GO:0000981
GeneOntologyMolecularFunction	UDP-galactosyltransferase activity	WDFY3 B3GNT3	1.43e-03	32	35	2	GO:0035250
GeneOntologyMolecularFunction	galactosyltransferase activity	WDFY3 B3GNT3	1.71e-03	35	35	2	GO:0008378
GeneOntologyBiologicalProcess	regulation of sperm capacitation	NXF2 ADAM7	5.84e-05	7	35	2	GO:1902490
Domain	zf-C2H2	ZNF462 ZNF267 ZNF12 ZNF677 ZNF480 ZNF431 POGZ ZSCAN16 ZNF660 ZNF391 ZNF714 ZNF646 ZNF662	6.53e-11	693	33	13	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF462 ZNF267 ZNF12 ZNF677 ZNF480 ZNF431 POGZ ZSCAN16 ZNF660 ZNF391 ZNF714 ZNF646 ZNF662	2.60e-10	775	33	13	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF462 ZNF267 ZNF12 ZNF677 ZNF480 ZNF431 POGZ ZSCAN16 ZNF660 ZNF391 ZNF714 ZNF646 ZNF662	2.68e-10	777	33	13	PS00028
Domain	Znf_C2H2-like	ZNF462 ZNF267 ZNF12 ZNF677 ZNF480 ZNF431 POGZ ZSCAN16 ZNF660 ZNF391 ZNF714 ZNF646 ZNF662	3.61e-10	796	33	13	IPR015880
Domain	Znf_C2H2	ZNF462 ZNF267 ZNF12 ZNF677 ZNF480 ZNF431 POGZ ZSCAN16 ZNF660 ZNF391 ZNF714 ZNF646 ZNF662	4.15e-10	805	33	13	IPR007087
Domain	ZnF_C2H2	ZNF462 ZNF267 ZNF12 ZNF677 ZNF480 ZNF431 POGZ ZSCAN16 ZNF660 ZNF391 ZNF714 ZNF646 ZNF662	4.34e-10	808	33	13	SM00355
Domain	-	ZNF462 ZNF267 ZNF12 ZNF677 ZNF480 ZNF431 ZSCAN16 ZNF660 ZNF391 ZNF714 ZNF646 ZNF662	8.52e-10	679	33	12	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF462 ZNF267 ZNF12 ZNF677 ZNF480 ZNF431 ZSCAN16 ZNF660 ZNF391 ZNF714 ZNF646 ZNF662	1.09e-09	694	33	12	IPR013087
Domain	zf-C2H2_6	ZNF267 ZNF12 ZNF677 ZNF480 ZNF431 ZNF660 ZNF391 ZNF714 ZNF646	2.59e-09	314	33	9	PF13912
Domain	KRAB	ZNF267 ZNF12 ZNF677 ZNF480 ZNF431 ZNF714 ZNF662	2.49e-06	358	33	7	PS50805
Domain	KRAB	ZNF267 ZNF12 ZNF677 ZNF480 ZNF431 ZNF714 ZNF662	3.05e-06	369	33	7	SM00349
Domain	KRAB	ZNF267 ZNF12 ZNF677 ZNF480 ZNF431 ZNF714 ZNF662	3.10e-06	370	33	7	IPR001909
Domain	KRAB	ZNF267 ZNF12 ZNF677 ZNF480 ZNF431	3.84e-04	358	33	5	PF01352
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF267 ZNF12 ZNF677 ZNF480 NR2C1 ZNF431 AGO2 GLS2 TP53INP1 ZNF660 ZNF714 ZNF662	6.89e-07	1387	24	12	M734
Pubmed	Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta.	ADAM7 ADAM5	3.30e-06	3	37	2	8163572
Pubmed	Expression and relationship of male reproductive ADAMs in mouse.	ADAM7 ADAM5	1.10e-05	5	37	2	16407499
Pubmed	Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression.	AGO2 TP53INP1	1.65e-05	6	37	2	26367773
Pubmed	Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations.	ADAM7 ADAM5	6.02e-05	11	37	2	24079728
Pubmed	Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.	ZNF462 WDFY3	1.31e-04	16	37	2	16096065
Pubmed	Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.	ZNF267 ZNF12	2.28e-04	21	37	2	7865130
Pubmed	DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.	ZNF267 ZNF431 ZSCAN16 AGO2	5.93e-04	364	37	4	31391242
Pubmed	Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.	ZNF462 SPAG17	7.16e-04	37	37	2	19266077
Interaction	LTBP2 interactions	ZNF12 ZNF480 ZNF431 ZNF714 ZNF646	4.03e-07	85	36	5	int:LTBP2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF462 ZNF267 ZNF12 ZNF677 ZNF480 ZNF431 ZSCAN16 ZNF660 ZNF391 ZNF714 ZNF646 ZNF662	4.54e-11	718	25	12	28
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADAM7 ADAM5	6.31e-04	27	25	2	47
Disease	Hernia	ZC3H11B ZNF391	1.59e-03	51	34	2	HP_0100790
Disease	fasting blood insulin measurement	ZNF12 ZC3H11B	2.88e-03	69	34	2	EFO_0004466
Disease	migraine disorder, Headache	ZNF462 GPR149	4.43e-03	86	34	2	HP_0002315, MONDO_0005277
Disease	osteoarthritis, hip	ZC3H11B SPAG17	5.06e-03	92	34	2	EFO_1000786
Disease	Neurodevelopmental Disorders	POGZ WDFY3	5.16e-03	93	34	2	C1535926
Disease	age-related hearing impairment	NID2 AGO2 SPAG17	6.10e-03	324	34	3	EFO_0005782
Disease	body surface area	ZNF462 ZC3H11B P4HA2 UNC79	6.17e-03	643	34	4	EFO_0022196
Disease	Colorectal Carcinoma	EML2 ZNF480 ZSCAN16 SPAG17	8.36e-03	702	34	4	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
CRPQFQRRFHHRMQK	ADAM5	11	Q6NVV9
VYRRNGHPHNKLRNR	ADAM7	211	Q9H2U9
RLKCQHFKQHRQYND	LINC02910	21	Q8N268
HPNRYCATVRVQQHR	AGO2	621	Q9UKV8
IINKHHRNRCQYCRL	NR2C1	156	P13056
KNHQIRACRFPYHLI	GTSF1	21	Q8WW33
PNHRRFLHNQICRQF	C19orf85	46	A0A1B0GUS0
HNYDNLRHCARKLDP	GLS2	461	Q9UI32
QKRLFCRYHHGNRAP	P4HA2	306	O15460
HRQNSKRQHQERDGY	GPR149	696	Q86SP6
HQNITYQVCRHAPRH	NID2	701	Q14112
QCHYAPSSVNRHQRK	FCAMR	81	Q8WWV6
QPQHVQNFLLYRHCR	B3GNT3	76	Q9Y2A9
QRQRHYLGHNDDIKC	EML2	96	O95834
LYKEEHLRNRQHPHC	EXOC3	471	O60645
HKDQQLRHTPYSIRC	NXF2	71	Q9GZY0
LGKHNYCRNPDNRRR	PLAU	116	P00749
HQKRNVYHCNKCRLQ	POGZ	641	Q7Z3K3
YSRNCHKFPHVRQLE	SPATA25	86	Q9BR10
VFHNPMNRQRLHCEY	SPAG17	821	Q6Q759
QHKRIHIRENSYQCE	ZNF431	221	Q8TF32
QHKRIHIRENSYQCE	ZNF714	161	Q96N38
AHNIVKYPQCRQHAL	WDFY3	576	Q8IZQ1
VCYHQRPDENVRRKH	TMEM190	66	Q8WZ59
RQNLTRDCHPRQVKH	TP53INP1	211	Q96A56
QHRRIHTGQRPYKCE	ZNF267	621	Q14586
HQRLHRREKPYKCNE	ZNF660	236	Q6AZW8
LAAYRNHLRNHPRCK	ZNF646	1091	O15015
QKLNCVFHHNRGRYV	ZC3H11B	76	A0A1B0GTU1
HQRIHSGQRPYKCNE	ZNF677	281	Q86XU0
RHQRIHTREKPYECN	ZNF480	276	Q8WV37
KCSPHRRELYRQHFR	ZSCAN16	31	Q9H4T2
ARHYRIKHNNVRAQP	ZNF462	1676	Q96JM2
RAICNHLRKHVQYGN	ZNF462	1981	Q96JM2
YQNSALCRHRRIHKG	ZNF12	531	P17014
HQRRHARDKPYNCQI	ZNF662	406	Q6ZS27
HGNRPVRYCKRCHSN	UNC79	396	Q9P2D8
HQRTHTQERPYKCNE	ZNF391	211	Q9UJN7