Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domainzf-Di19

ZEB1 ZEB2

5.21e-057302PF05605
DomainDi19_Zn_binding_dom

ZEB1 ZEB2

5.21e-057302IPR008598
DomainCalcineurin-like_PHP_ApaH

ACP7 PPP3CB

9.19e-0428302IPR004843
DomainMetallophos

ACP7 PPP3CB

9.19e-0428302PF00149
DomainMetallo-depent_PP-like

ACP7 PPP3CB

1.06e-0330302IPR029052
Domain-

ACP7 PPP3CB

1.06e-03303023.60.21.10
DomainIg_2

FCRLB LILRA2

6.11e-0373302PF13895
Pubmed

The Zeb proteins δEF1 and Sip1 may have distinct functions in lens cells following cataract surgery.

ZEB1 ZEB2

8.20e-07232225082886
Pubmed

ZEBs: Novel Players in Immune Cell Development and Function.

ZEB1 ZEB2

8.20e-07232230956067
Pubmed

Prognostic significance of ZEB1 and ZEB2 in digestive cancers: a cohort-based analysis and secondary analysis.

ZEB1 ZEB2

8.20e-07232228416756
Pubmed

Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway.

ZEB1 ZEB2

8.20e-07232220025777
Pubmed

Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors.

ZEB1 ZEB2

8.20e-07232220424117
Pubmed

Zfhx1a and Zfhx1b mRNAs have non-overlapping expression domains during chick and mouse midgestation limb development.

ZEB1 ZEB2

8.20e-07232212609600
Pubmed

Expression of miRNAs and ZEB1 and ZEB2 correlates with histopathological grade in papillary urothelial tumors of the urinary bladder.

ZEB1 ZEB2

8.20e-07232224306957
Pubmed

Either ZEB1 or ZEB2/SIP1 can play a central role in regulating the Epstein-Barr virus latent-lytic switch in a cell-type-specific manner.

ZEB1 ZEB2

8.20e-07232220375168
Pubmed

Prognostic Significance of Zinc Finger E-Box-Binding Homeobox Family in Glioblastoma.

ZEB1 ZEB2

8.20e-07232229476046
Pubmed

Epithelial-mesenchymal transition and mesenchymal-epithelial transition via regulation of ZEB-1 and ZEB-2 expression in pancreatic cancer.

ZEB1 ZEB2

8.20e-07232222213144
Pubmed

TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.

ZEB1 ZEB2

8.20e-07232221747944
Pubmed

Functional conservation of zinc-finger homeodomain gene zfh1/SIP1 in Drosophila heart development.

ZEB1 ZEB2

8.20e-07232216957952
Pubmed

ZEB1-induced LINC01559 expedites cell proliferation, migration and EMT process in gastric cancer through recruiting IGF2BP2 to stabilize ZEB1 expression.

IGF2BP2 ZEB1

8.20e-07232233824282
Pubmed

The adaptive antioxidant response during fasting-induced muscle atrophy is oppositely regulated by ZEB1 and ZEB2.

ZEB1 ZEB2

8.20e-07232237948583
Pubmed

The mesodermal and myogenic specification of hESCs depend on ZEB1 and are inhibited by ZEB2.

ZEB1 ZEB2

8.20e-07232237819755
Pubmed

The role of epithelial-mesenchymal transition drivers ZEB1 and ZEB2 in mediating docetaxel-resistant prostate cancer.

ZEB1 ZEB2

8.20e-07232228133913
Pubmed

Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity.

ZEB1 ZEB2

8.20e-07232234550965
Pubmed

Epithelial-mesenchymal transition transcription factor ZEB1/ZEB2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer.

ZEB1 ZEB2

8.20e-07232222892238
Pubmed

Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype.

ZEB1 ZEB2

2.46e-06332223412770
Pubmed

A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors.

ZEB1 ZEB2

2.46e-06332221890822
Pubmed

TCF4 promotes colorectal cancer drug resistance and stemness via regulating ZEB1/ZEB2 expression.

ZEB1 ZEB2

2.46e-06332231933004
Pubmed

Down-regulation of miR-144 promotes thyroid cancer cell invasion by targeting ZEB1 and ZEB2.

ZEB1 ZEB2

2.46e-06332224968735
Pubmed

Src promotes EGF-induced epithelial-to-mesenchymal transition and migration in gastric cancer cells by upregulating ZEB1 and ZEB2 through AKT.

ZEB1 ZEB2

2.46e-06332229052277
Pubmed

Expression of miR-9 and miR-200c, ZEB1, ZEB2 and E-cadherin in Non-Small Cell Lung Cancers in Iran.

ZEB1 ZEB2

2.46e-06332231244281
Pubmed

miR-144-3p inhibited the growth, metastasis and epithelial-mesenchymal transition of colorectal adenocarcinoma by targeting ZEB1/2.

ZEB1 ZEB2

2.46e-06332234226299
Pubmed

Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta.

ZEB1 ZEB2

2.46e-06332217615296
Pubmed

miR-590-3p suppresses cancer cell migration, invasion and epithelial-mesenchymal transition in glioblastoma multiforme by targeting ZEB1 and ZEB2.

ZEB1 ZEB2

2.46e-06332226556542
Pubmed

The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins.

ZEB1 ZEB2

2.46e-06332226823172
Pubmed

A miRNA signature associated with human metastatic medullary thyroid carcinoma.

ZEB1 ZEB2

2.46e-06332224127332
Pubmed

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.

ZEB1 ZEB2

2.46e-06332218376396
Pubmed

p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2.

ZEB1 ZEB2

2.46e-06332221518799
Pubmed

The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2.

ZEB1 ZEB2

2.46e-06332218411277
Pubmed

miR-139-5p suppresses cancer cell migration and invasion through targeting ZEB1 and ZEB2 in GBM.

ZEB1 ZEB2

2.46e-06332225833697
Pubmed

miR-139-5p inhibits epithelial-mesenchymal transition, migration and invasion of hepatocellular carcinoma cells by targeting ZEB1 and ZEB2.

ZEB1 ZEB2

2.46e-06332226022123
Pubmed

An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.

ZEB1 ZEB2

2.46e-06332221411626
Pubmed

BMP4 signaling mediates Zeb family in developing mouse tooth.

ZEB1 ZEB2

2.46e-06332222350174
Pubmed

Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2.

ZEB1 ZEB2

2.46e-06332224165969
Pubmed

miR-200c inhibits TGF-β-induced-EMT to restore trastuzumab sensitivity by targeting ZEB1 and ZEB2 in gastric cancer.

ZEB1 ZEB2

2.46e-06332229302045
Pubmed

Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.

TEX14 SCD5 TERF1

2.54e-062932338485951
Pubmed

Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFβ expression.

ZEB1 ZEB2

4.92e-06432225301070
Pubmed

miR-200b regulates cell migration via Zeb family during mouse palate development.

ZEB1 ZEB2

4.92e-06432222261924
Pubmed

MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors.

ZEB1 ZEB2

4.92e-06432217360662
Pubmed

Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma.

ZEB1 ZEB2

4.92e-06432223381389
Pubmed

Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependent on ERK1/2 activity, in breast cancer cells.

ZEB1 ZEB2

4.92e-06432228247944
Pubmed

Complementary expression pattern of Zfhx1 genes Sip1 and deltaEF1 in the mouse embryo and their genetic interaction revealed by compound mutants.

ZEB1 ZEB2

4.92e-06432216598713
Pubmed

MiR-525-5p Repressed Metastasis and Anoikis Resistance in Cervical Cancer via Blocking UBE2C/ZEB1/2 Signal Axis.

ZEB1 ZEB2

4.92e-06432231679088
Pubmed

miR-200b/c attenuates lipopolysaccharide-induced early pulmonary fibrosis by targeting ZEB1/2 via p38 MAPK and TGF-β/smad3 signaling pathways.

ZEB1 ZEB2

4.92e-06432229200203
Pubmed

miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor.

ZEB1 ZEB2

4.92e-06432221079000
Pubmed

The MicroRNA 29 Family Promotes Type II Cell Differentiation in Developing Lung.

ZEB1 ZEB2

4.92e-06432227215389
Pubmed

A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition.

ZEB1 ZEB2

8.19e-06532218829540
Pubmed

ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates.

ZEB1 ZEB2

8.19e-06532229449309
Pubmed

Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins.

ZEB1 ZEB2

8.19e-06532212743039
Pubmed

Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway.

ZEB1 ZEB2

8.19e-06532212743038
Pubmed

A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression.

ZEB1 ZEB2

8.19e-06532219651985
Pubmed

Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression.

ZEB1 ZEB2

1.23e-05632212161443
Pubmed

miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5.

ZEB1 ZEB2

1.23e-05632222685266
Pubmed

Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.

ZEB1 ZEB2

2.29e-05832216061479
Pubmed

Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors.

ZEB1 ZEB2

2.29e-05832225460509
Pubmed

A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration.

ZEB1 ZEB2

2.29e-05832230271956
Pubmed

Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin.

ZEB1 ZEB2

2.29e-05832212714599
Pubmed

Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.

ZEB1 USP24

2.94e-05932237149635
Pubmed

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression.

ZEB1 ZEB2

2.94e-05932224769727
Pubmed

Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin.

ZEB1 ZEB2

3.67e-051032234193422
Pubmed

Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.

ZEB1 ZEB2

7.41e-051432226324903
Pubmed

Deletion of Yy1 in mouse lung epithelium unveils molecular mechanisms governing pleuropulmonary blastoma pathogenesis.

ZEB1 ZEB2

8.55e-051532233158935
Pubmed

TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties.

ZEB1 ZEB2

9.76e-051632236418889
Pubmed

Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons.

ZEB1 ZEB2

9.76e-051632225942625
Pubmed

Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2.

ZEB1 ZEB2

1.11e-041732231171776
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ZEB2 ZNF862 PCLO

1.24e-041053239628581
Pubmed

Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development.

ZEB1 ZEB2

1.70e-042132224161570
Pubmed

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.

PPP3CB TRIM6

2.24e-042432227693506
Pubmed

Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.

ZEB1 ZEB2

2.63e-042632226212757
Pubmed

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.

PKP2 NEK1 IGF2BP2 PPP3CB SCD5 STT3B

2.76e-04100732634597346
Pubmed

Maternal DNA Methylation Regulates Early Trophoblast Development.

ZEB1 ZEB2

3.05e-042832226812015
Pubmed

Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure.

ZEB1 ZEB2

3.05e-042832232005677
Pubmed

Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.

ZEB1 ZEB2

3.75e-043132223312518
Pubmed

Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor.

ZEB1 ZEB2

4.00e-043232227806288
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

NEK1 ZEB1 ZEB2 USP24

5.67e-0441832434709266
Pubmed

Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development.

ZEB2 FOXF2

8.64e-044732239001875
CytobandEnsembl 112 genes in cytogenetic band chr3q27

IGF2BP2 EEF1AKMT4

3.62e-03128322chr3q27
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZEB1 ZEB2

1.21e-0415202529
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZEB1 ZEB2 ZNF862 ZNF461

7.19e-0371820428
GeneFamilyImmunoglobulin like domain containing

FCRLB PTPRK

1.90e-02193202594
ToppCellfacs-Aorta-Heart-24m-Endothelial-endocardial_endothelial_cells|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EMP1 SCD5 RUBCN FOXF2

6.22e-06168324edbab94f14e16a1a76546a18fe777a183080d1de
ToppCellBrain_organoid-organoid_Velasco_nature-3_mon-Neuronal-CPNs|3_mon / Sample Type, Dataset, Time_group, and Cell type.

PPP3CB SCD5 PTPRK ZEB2

1.19e-0519832460d8d3bbd754ffde41c50013d822667b185a9751
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer|World / Primary Cells by Cluster

SCD5 PTPRK ZEB2 PCLO

1.24e-05200324db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21|World / Primary Cells by Cluster

SCD5 PTPRK ZEB2 PCLO

1.24e-0520032430a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
DrugCefaclor [70356-03-5]; Down 200; 10.4uM; HL60; HT_HG-U133A

LILRA2 IGF2BP2 ZEB1 EMP1 RUBCN

6.52e-061973152483_DN
Diseaserheumatic heart disease (biomarker_via_orthology)

ZEB1 ZEB2

7.00e-0512312DOID:0050827 (biomarker_via_orthology)
DiseaseFamilial Nonmedullary Thyroid Cancer

ZEB1 ZEB2

1.88e-0361312C3501844
DiseaseNonmedullary Thyroid Carcinoma

ZEB1 ZEB2

1.88e-0361312C3501843
Diseasenicotine dependence symptom count, depressive symptom measurement

IGF2BP2 PCLO

2.83e-0375312EFO_0007006, EFO_0009262
DiseasePapillary thyroid carcinoma

ZEB1 ZEB2

3.70e-0386312C0238463
DiseaseUterine leiomyoma

IGF2BP2 ZEB1

4.13e-0391312HP_0000131
DiseaseAbortion, Tubal

DIAPH2-AS1 EMP1

5.86e-03109312C0000822
DiseaseEarly Pregnancy Loss

DIAPH2-AS1 EMP1

5.86e-03109312C3830362
DiseaseMiscarriage

DIAPH2-AS1 EMP1

5.86e-03109312C4552766
DiseaseSpontaneous abortion

DIAPH2-AS1 EMP1

5.86e-03109312C0000786

Protein segments in the cluster

PeptideGeneStartEntry
RNHSYHLRYHGSSYS

DIAPH2-AS1

46

Q14236
FELGYYHKHAFNNYH

AMER1

841

Q5JTC6
YHKHAFNNYHSRFYQ

AMER1

846

Q5JTC6
QHHFSLSSVYSHYFP

ANGEL2

446

Q5VTE6
HAGRYHCQYYSHNHS

LILRA2

91

Q8N149
SFSTEVYFFLHYGRH

ACP7

241

Q6ZNF0
YTSHYANRDGTQYHH

EMP1

116

P54849
SFSSRGQYEHYHAIF

NEK1

436

Q96PY6
HLAGLSHYYHADTSY

PCLO

4141

Q9Y6V0
FRCYHFIFHSSTHLG

MMAA

21

Q8IVH4
THSGYFSSLYPHHQF

IGF2BP2

401

Q9Y6M1
MHNFEHYFGFFHYIR

QTRT2

381

Q9H974
DYSLHHISQFFRSHY

EPHX3

206

Q9H6B9
HFYFTCSFKTYEHQH

CXorf1

71

O96002
TAYFLTHFHSDHYAG

DCLRE1A

726

Q6PJP8
HYYHDGQAVRYFHSS

FCRLB

136

Q6BAA4
HFSHNTVRGCSYFYN

PPP3CB

256

P16298
YAQHSYFGSFSSLHQ

RUBCN

221

Q92622
HTFNVTICYHYFRGH

PTPRK

421

Q15262
ISSFHPSASGSYYHH

FOXF2

416

Q12947
YLHFQGFIHRSLSSY

TEX14

366

Q8IWB6
VHSRNGYYNGHTFHR

PPWD1

521

Q96BP3
FHNYHHTFPFDYSAS

SCD5

271

Q86SK9
RHATYGSGFHFHLYL

EEF1AKMT4

196

P0DPD7
FNYRSTHHLASHGFY

STT3B

106

Q8TCJ2
KDTFHSFFQHFSYNH

TERF1

221

P54274
EHFFNAAYSIAYHSR

ZNF862

556

O60290
HSGSYSQHMNHRYSY

ZEB1

971

P37275
VHSGQAHAGHYYSFI

USP24

1961

Q9UPU5
HSGSYSQHMNHRYSY

ZEB2

1066

O60315
TSHFLANYLTTHFYG

ZFYVE26

1626

Q68DK2
QRHFDTYHRQYQHGS

PKP2

211

Q99959
SFNHFAQNHSAYSRY

TRIM6

381

Q9C030
FSYHLFFSHHKRTHS

ZNF461

201

Q8TAF7