Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

GATA2 FOXD2 SHOX POU4F1 POU4F3 OTX1 TCF7L2 HNF4A HNF4G MEIS2 HAND2 TLX1

1.83e-115603112GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

GATA2 FOXD2 SHOX POU4F1 POU4F3 OTX1 TCF7L2 HNF4A HNF4G MEIS2 HAND2 TLX1

2.07e-115663112GO:0001216
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

GATA2 FOXD2 SHOX HSFX1 POU4F1 POU4F3 OTX1 TCF7L2 HNF4A HNF4G OLIG2 MEIS2 HAND2 TLX1

6.20e-0914123114GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

GATA2 FOXD2 HSFX1 POU4F1 POU4F3 OTX1 TCF7L2 HNF4A HNF4G OLIG2 MEIS2 HAND2 TLX1

1.44e-0812443113GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

GATA2 FOXD2 HSFX1 POU4F1 POU4F3 OTX1 TCF7L2 HNF4A HNF4G OLIG2 MEIS2 HAND2 TLX1

1.86e-0812713113GO:0000987
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

GATA2 FOXD2 HSFX1 POU4F1 POU4F3 OTX1 TCF7L2 HNF4A HNF4G OLIG2 MEIS2 HAND2 TLX1

9.51e-0814593113GO:0000977
GeneOntologyMolecularFunctiontranscription factor binding

GATA2 CITED2 MED12L POU4F1 TCF7L2 HNF4A MEIS2 HAND2

1.44e-05753318GO:0008134
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

GATA2 CITED2 POU4F1 TCF7L2 HNF4A HAND2

3.78e-05417316GO:0061629
GeneOntologyMolecularFunctionchromatin binding

GATA2 CITED2 POU4F1 TCF7L2 OGT RERE HNF4A

1.12e-04739317GO:0003682
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

GATA2 CITED2 POU4F1 TCF7L2 HNF4A HAND2

2.36e-04582316GO:0140297
GeneOntologyMolecularFunctiontranscription coregulator binding

GATA2 HNF4A HAND2

1.31e-03140313GO:0001221
GeneOntologyMolecularFunctionprotein domain specific binding

GATA2 CITED2 TCF7L2 OGT HNF4A OLIG2

2.00e-03875316GO:0019904
GeneOntologyMolecularFunctiontranscription coactivator binding

GATA2 HAND2

3.17e-0354312GO:0001223
GeneOntologyMolecularFunctionnuclear receptor activity

HNF4A HNF4G

3.90e-0360312GO:0004879
GeneOntologyMolecularFunctionligand-activated transcription factor activity

HNF4A HNF4G

4.03e-0361312GO:0098531
GeneOntologyMolecularFunctionE-box binding

OLIG2 HAND2

4.03e-0361312GO:0070888
GeneOntologyMolecularFunctionSMAD binding

CITED2 RNF111

7.86e-0386312GO:0046332
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

GATA2 CITED2 FOXD2 MED12L SHOX POU4F1 POU4F3 OTX1 TCF7L2 OGT HNF4A HNF4G OLIG2 MEIS2 HAND2 TLX1

1.90e-1113903116GO:0045944
GeneOntologyBiologicalProcessdiencephalon development

GATA2 POU4F1 OTX1 TCF7L2 OLIG2

2.20e-0790315GO:0021536
GeneOntologyBiologicalProcessembryonic morphogenesis

GATA2 CITED2 PHLDB1 POU4F3 OTX1 TCF7L2 HNF4A HAND2

7.64e-06713318GO:0048598
GeneOntologyBiologicalProcessembryonic organ morphogenesis

GATA2 CITED2 POU4F3 OTX1 TCF7L2 HAND2

1.20e-05351316GO:0048562
GeneOntologyBiologicalProcesscentral nervous system development

GATA2 CITED2 POU4F1 OTX1 TCF7L2 RERE OLIG2 MEIS2 TLX1

4.56e-051197319GO:0007417
GeneOntologyBiologicalProcessanimal organ morphogenesis

GATA2 CITED2 POU4F1 POU4F3 OTX1 TCF7L2 MEIS2 HAND2 TLX1

7.20e-051269319GO:0009887
GeneOntologyBiologicalProcesssensory organ development

GATA2 CITED2 POU4F3 OTX1 OLIG2 MEIS2 HAND2

8.46e-05730317GO:0007423
GeneOntologyBiologicalProcesscell fate commitment

GATA2 POU4F1 TCF7L2 OLIG2 TLX1

1.37e-04338315GO:0045165
GeneOntologyBiologicalProcesscranial nerve development

CITED2 POU4F1 POU4F3

1.38e-0467313GO:0021545
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

GATA2 CITED2 POU4F1 TCF7L2 OGT RERE HNF4A OLIG2 MEIS2

1.52e-041399319GO:0045892
GeneOntologyBiologicalProcessembryonic organ development

GATA2 CITED2 POU4F3 OTX1 TCF7L2 HAND2

1.63e-04561316GO:0048568
GeneOntologyBiologicalProcessregulation of gluconeogenesis

TCF7L2 OGT HNF4A

1.64e-0471313GO:0006111
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

GATA2 CITED2 POU4F1 TCF7L2 OGT RERE HNF4A OLIG2 MEIS2

1.64e-041413319GO:1902679
GeneOntologyBiologicalProcessembryo development

GATA2 CITED2 PHLDB1 POU4F3 OTX1 TCF7L2 HNF4A MEIS2 HAND2

1.87e-041437319GO:0009790
GeneOntologyBiologicalProcessanimal organ formation

CITED2 HAND2 TLX1

2.17e-0478313GO:0048645
GeneOntologyBiologicalProcessbrain development

GATA2 POU4F1 OTX1 TCF7L2 RERE OLIG2 MEIS2

2.32e-04859317GO:0007420
GeneOntologyBiologicalProcesshindbrain development

GATA2 POU4F1 OTX1 RERE

2.55e-04208314GO:0030902
GeneOntologyBiologicalProcessperipheral nervous system neuron development

POU4F1 HAND2

2.59e-0416312GO:0048935
GeneOntologyBiologicalProcessperipheral nervous system neuron differentiation

POU4F1 HAND2

2.59e-0416312GO:0048934
GeneOntologyBiologicalProcessnegative regulation of epithelial cell apoptotic process

GATA2 TCF7L2 HAND2

2.89e-0486313GO:1904036
GeneOntologyBiologicalProcessnegative regulation of developmental process

GATA2 CITED2 FNDC3B TCF7L2 OGT OLIG2 MEIS2 HAND2

3.40e-041220318GO:0051093
GeneOntologyBiologicalProcessneuron fate commitment

GATA2 POU4F1 OLIG2

3.41e-0491313GO:0048663
GeneOntologyBiologicalProcesshead development

GATA2 POU4F1 OTX1 TCF7L2 RERE OLIG2 MEIS2

3.50e-04919317GO:0060322
GeneOntologyBiologicalProcesssuckling behavior

POU4F1 HAND2

3.68e-0419312GO:0001967
GeneOntologyBiologicalProcesscardiac neural crest cell differentiation involved in heart development

CITED2 HAND2

3.68e-0419312GO:0061307
GeneOntologyBiologicalProcesscardiac neural crest cell development involved in heart development

CITED2 HAND2

3.68e-0419312GO:0061308
GeneOntologyBiologicalProcessregulation of gastrulation

PHLDB1 HNF4A

4.08e-0420312GO:0010470
GeneOntologyBiologicalProcesspositive regulation of transcription regulatory region DNA binding

POU4F1 HAND2

4.08e-0420312GO:2000679
GeneOntologyBiologicalProcessperipheral nervous system development

CITED2 POU4F1 HAND2

4.24e-0498313GO:0007422
GeneOntologyBiologicalProcesscell migration in hindbrain

POU4F1 RERE

5.42e-0423312GO:0021535
GeneOntologyBiologicalProcessnerve development

CITED2 POU4F1 POU4F3

5.79e-04109313GO:0021675
GeneOntologyBiologicalProcessgluconeogenesis

TCF7L2 OGT HNF4A

6.11e-04111313GO:0006094
GeneOntologyBiologicalProcessregulation of neurotransmitter receptor localization to postsynaptic specialization membrane

OGT IQSEC2

6.42e-0425312GO:0098696
GeneOntologyBiologicalProcesshexose biosynthetic process

TCF7L2 OGT HNF4A

6.77e-04115313GO:0019319
GeneOntologyBiologicalProcessforebrain development

GATA2 POU4F1 OTX1 TCF7L2 OLIG2

7.49e-04489315GO:0030900
GeneOntologyBiologicalProcesspositive regulation of lipid biosynthetic process

TCF7L2 OGT HNF4A

7.85e-04121313GO:0046889
GeneOntologyBiologicalProcessmonosaccharide biosynthetic process

TCF7L2 OGT HNF4A

7.85e-04121313GO:0046364
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

GATA2 CITED2 POU4F1 TCF7L2 OGT OLIG2 MEIS2

7.92e-041053317GO:0000122
GeneOntologyBiologicalProcesscatechol-containing compound biosynthetic process

HAND2 HDC

8.65e-0429312GO:0009713
GeneOntologyBiologicalProcesscatecholamine biosynthetic process

HAND2 HDC

8.65e-0429312GO:0042423
GeneOntologyBiologicalProcessinner ear morphogenesis

GATA2 POU4F3 OTX1

9.45e-04129313GO:0042472
GeneOntologyBiologicalProcessmesenchymal cell differentiation

CITED2 PHLDB1 TCF7L2 HAND2

9.63e-04296314GO:0048762
GeneOntologyBiologicalProcessregulation of carbohydrate biosynthetic process

TCF7L2 OGT HNF4A

1.01e-03132313GO:0043255
GeneOntologyBiologicalProcesshematopoietic or lymphoid organ development

CITED2 HAND2 TLX1

1.03e-03133313GO:0048534
GeneOntologyBiologicalProcesspattern specification process

CITED2 OTX1 MEIS2 HAND2 RNF111

1.04e-03526315GO:0007389
GeneOntologyBiologicalProcesspositive regulation of gluconeogenesis

TCF7L2 HNF4A

1.05e-0332312GO:0045722
GeneOntologyBiologicalProcessregulation of glucose metabolic process

TCF7L2 OGT HNF4A

1.05e-03134313GO:0010906
GeneOntologyBiologicalProcesspositive regulation of cellular response to transforming growth factor beta stimulus

CITED2 RNF111

1.26e-0335312GO:1903846
GeneOntologyBiologicalProcesspositive regulation of transforming growth factor beta receptor signaling pathway

CITED2 RNF111

1.26e-0335312GO:0030511
GeneOntologyBiologicalProcessregulation of protein localization to synapse

OGT IQSEC2

1.49e-0338312GO:1902473
GeneOntologyBiologicalProcessregulation of epithelial cell apoptotic process

GATA2 TCF7L2 HAND2

1.52e-03152313GO:1904035
GeneOntologyBiologicalProcessregulation of receptor localization to synapse

OGT IQSEC2

1.56e-0339312GO:1902683
GeneOntologyBiologicalProcessear morphogenesis

GATA2 POU4F3 OTX1

1.57e-03154313GO:0042471
GeneOntologyBiologicalProcesssensory organ morphogenesis

GATA2 CITED2 POU4F3 OTX1

1.66e-03343314GO:0090596
GeneOntologyBiologicalProcessnegative regulation of cell differentiation

GATA2 FNDC3B TCF7L2 OLIG2 MEIS2 HAND2

1.70e-03875316GO:0045596
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

CITED2 TCF7L2 OGT RNF111

1.73e-03347314GO:0090092
GeneOntologyBiologicalProcessresponse to growth factor

CITED2 CSTF2 TCF7L2 OGT MEIS2 RNF111

1.78e-03883316GO:0070848
GeneOntologyBiologicalProcessendocrine system development

GATA2 CITED2 TCF7L2

1.79e-03161313GO:0035270
GeneOntologyBiologicalProcesscardiac chamber morphogenesis

CITED2 POU4F1 HAND2

1.79e-03161313GO:0003206
GeneOntologyBiologicalProcesscardiac ventricle development

CITED2 POU4F1 HAND2

1.79e-03161313GO:0003231
GeneOntologyBiologicalProcesspositive regulation of lipid metabolic process

TCF7L2 OGT HNF4A

1.92e-03165313GO:0045834
GeneOntologyBiologicalProcessregulation of fat cell differentiation

GATA2 FNDC3B TCF7L2

2.02e-03168313GO:0045598
GeneOntologyBiologicalProcesspituitary gland development

GATA2 TCF7L2

2.08e-0345312GO:0021983
GeneOntologyBiologicalProcesspositive regulation of binding

POU4F1 TCF7L2 HAND2

2.09e-03170313GO:0051099
GeneOntologyBiologicalProcessregulation of transcription regulatory region DNA binding

POU4F1 HAND2

2.17e-0346312GO:2000677
GeneOntologyBiologicalProcessregulation of nervous system development

GATA2 POU4F1 TCF7L2 OLIG2 IQSEC2

2.22e-03625315GO:0051960
GeneOntologyBiologicalProcessmesenchyme development

CITED2 PHLDB1 TCF7L2 HAND2

2.23e-03372314GO:0060485
GeneOntologyBiologicalProcessbiogenic amine biosynthetic process

HAND2 HDC

2.27e-0347312GO:0042401
GeneOntologyBiologicalProcessregulation of protein localization to nucleus

TCF7L2 OGT HNF4A

2.30e-03176313GO:1900180
GeneOntologyBiologicalProcessamine biosynthetic process

HAND2 HDC

2.36e-0348312GO:0009309
GeneOntologyBiologicalProcessneurotransmitter receptor localization to postsynaptic specialization membrane

OGT IQSEC2

2.46e-0349312GO:0099645
GeneOntologyBiologicalProcessprotein localization to postsynaptic specialization membrane

OGT IQSEC2

2.46e-0349312GO:0099633
GeneOntologyCellularComponentchromatin

CITED2 FOXD2 SHOX HSFX1 POU4F1 POU4F3 OTX1 TCF7L2 OGT HNF4A HNF4G OLIG2 MEIS2 HAND2 TLX1

5.35e-1014803115GO:0000785
GeneOntologyCellularComponenttranscription regulator complex

GATA2 POU4F1 POU4F3 TCF7L2 HNF4G OLIG2 HAND2

2.14e-05596317GO:0005667
GeneOntologyCellularComponentcell cortex region

PHLDB1 IQSEC2

2.03e-0345312GO:0099738
MousePhenoperinatal lethality, complete penetrance

CITED2 FNDC3B ZSWIM8 POU4F1 OTX1 TCF7L2 RERE OLIG2 HAND2

3.13e-06712269MP:0011089
MousePhenoperinatal lethality

GATA2 CITED2 FNDC3B ZSWIM8 POU4F1 OTX1 TCF7L2 RERE OLIG2 HAND2

1.83e-0511302610MP:0002081
MousePhenoneonatal lethality, complete penetrance

FNDC3B ZSWIM8 POU4F1 OTX1 TCF7L2 OLIG2 HAND2

3.98e-05534267MP:0011087
MousePhenoabnormal sensory ganglion morphology

CITED2 POU4F1 POU4F3 OLIG2 MEIS2

4.74e-05221265MP:0000960
MousePhenolethality during fetal growth through weaning, complete penetrance

CITED2 FNDC3B ZSWIM8 POU4F1 OTX1 TCF7L2 RERE OLIG2 MEIS2 HAND2

5.02e-0512692610MP:0011111
MousePhenoabnormal right subclavian artery morphology

CITED2 TCF7L2 RERE

5.39e-0540263MP:0010487
MousePhenoabnormal heart septum morphology

CITED2 ZSWIM8 TCF7L2 RERE MEIS2 HAND2

6.32e-05388266MP:0006113
MousePhenoabnormal cardiac outflow tract development

CITED2 TCF7L2 MEIS2 HAND2

1.02e-04134264MP:0006126
MousePhenoabnormal subclavian artery morphology

CITED2 TCF7L2 RERE

1.48e-0456263MP:0003395
MousePhenoabnormal cranial ganglia morphology

CITED2 POU4F1 POU4F3 MEIS2

2.86e-04175264MP:0001081
MousePhenoabnormal interventricular septum morphology

CITED2 ZSWIM8 TCF7L2 RERE HAND2

3.67e-04342265MP:0000281
MousePhenoabnormal iris morphology

CITED2 MED12L OTX1 GPNMB

4.07e-04192264MP:0001322
MousePhenosmall cochlear ganglion

POU4F1 POU4F3

4.45e-0417262MP:0003986
MousePhenoabnormal anterior uvea morphology

CITED2 MED12L OTX1 GPNMB

4.66e-04199264MP:0005194
MousePhenoneonatal lethality

FNDC3B ZSWIM8 POU4F1 OTX1 TCF7L2 OLIG2 HAND2

4.90e-04799267MP:0002058
MousePhenoabnormal truncus arteriosus septation

CITED2 TCF7L2 MEIS2

4.93e-0484263MP:0010454
MousePhenoabnormal heart and great artery attachment

CITED2 TCF7L2 RERE MEIS2

5.21e-04205264MP:0010426
MousePhenoabnormal heart and great vessel attachment

CITED2 TCF7L2 RERE MEIS2

5.51e-04208264MP:0010425
MousePhenoabnormal ureter morphology

GATA2 FOXD2 TCF7L2

6.03e-0490263MP:0000534
MousePhenosmall trigeminal ganglion

POU4F1 MEIS2

6.19e-0420262MP:0001093
MousePhenosmall dorsal root ganglion

CITED2 POU4F1

8.95e-0424262MP:0000964
MousePhenoabnormal vestibular ganglion morphology

POU4F1 POU4F3

8.95e-0424262MP:0002856
MousePhenoabnormal dorsal root ganglion morphology

CITED2 POU4F1 OLIG2

9.18e-04104263MP:0000961
MousePhenoabnormal uvea morphology

CITED2 MED12L OTX1 GPNMB

9.56e-04241264MP:0005197
MousePhenodecreased brain weight

OTX1 OGT RERE

9.71e-04106263MP:0002175
DomainHomeodomain-like

SHOX POU4F1 POU4F3 OTX1 RERE MEIS2 TLX1

7.54e-07332307IPR009057
DomainHomeobox

SHOX POU4F1 POU4F3 OTX1 MEIS2 TLX1

1.67e-06234306PF00046
DomainHOMEOBOX_1

SHOX POU4F1 POU4F3 OTX1 MEIS2 TLX1

1.76e-06236306PS00027
DomainHOX

SHOX POU4F1 POU4F3 OTX1 MEIS2 TLX1

1.80e-06237306SM00389
DomainHomeobox_dom

SHOX POU4F1 POU4F3 OTX1 MEIS2 TLX1

1.89e-06239306IPR001356
DomainHOMEOBOX_2

SHOX POU4F1 POU4F3 OTX1 MEIS2 TLX1

1.89e-06239306PS50071
Domain-

GATA2 RERE HNF4A HNF4G

2.01e-06573043.30.50.10
DomainZnf_NHR/GATA

GATA2 RERE HNF4A HNF4G

2.16e-0658304IPR013088
Domain-

SHOX POU4F1 POU4F3 OTX1 MEIS2 TLX1

5.02e-062833061.10.10.60
DomainHomeobox_CS

SHOX POU4F1 POU4F3 OTX1 TLX1

1.08e-05186305IPR017970
DomainCOUP_TF

HNF4A HNF4G

2.49e-055302IPR003068
DomainRetinoid-X_rcpt/HNF4

HNF4A HNF4G

1.11e-0410302IPR000003
DomainZnF_GATA

GATA2 RERE

1.63e-0412302SM00401
DomainZnf_GATA

GATA2 RERE

2.59e-0415302IPR000679
DomainGATA

GATA2 RERE

2.59e-0415302PF00320
DomainPOU

POU4F1 POU4F3

2.95e-0416302SM00352
DomainGATA_ZN_FINGER_1

GATA2 RERE

2.95e-0416302PS00344
DomainPOU_2

POU4F1 POU4F3

2.95e-0416302PS00465
DomainPou

POU4F1 POU4F3

2.95e-0416302PF00157
DomainPOU_dom

POU4F1 POU4F3

2.95e-0416302IPR000327
DomainGATA_ZN_FINGER_2

GATA2 RERE

2.95e-0416302PS50114
DomainPOU_3

POU4F1 POU4F3

2.95e-0416302PS51179
DomainPOU_1

POU4F1 POU4F3

2.95e-0416302PS00035
DomainPOU

POU4F1 POU4F3

3.34e-0417302IPR013847
Domain-

POU4F1 POU4F3

8.54e-04273021.10.260.40
DomainLambda_DNA-bd_dom

POU4F1 POU4F3

9.86e-0429302IPR010982
Domainzf-C4

HNF4A HNF4G

2.47e-0346302PF00105
DomainNUCLEAR_REC_DBD_1

HNF4A HNF4G

2.47e-0346302PS00031
DomainZnf_hrmn_rcpt

HNF4A HNF4G

2.47e-0346302IPR001628
DomainNuclear_hrmn_rcpt

HNF4A HNF4G

2.47e-0346302IPR001723
DomainZnF_C4

HNF4A HNF4G

2.47e-0346302SM00399
DomainNUCLEAR_REC_DBD_2

HNF4A HNF4G

2.47e-0346302PS51030
Domain-

HNF4A HNF4G

2.58e-03473021.10.565.10
DomainHOLI

HNF4A HNF4G

2.69e-0348302SM00430
DomainNucl_hrmn_rcpt_lig-bd

HNF4A HNF4G

2.69e-0348302IPR000536
DomainHormone_recep

HNF4A HNF4G

2.69e-0348302PF00104
Domain-

OLIG2 HAND2

1.32e-021093024.10.280.10
DomainHLH

OLIG2 HAND2

1.37e-02111302PF00010
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

GATA2 CITED2 CSTF2 POU4F1 TCF7L2 OGT HNF4A RNF111

2.73e-051022198MM15436
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

GATA2 CITED2 CSTF2 POU4F1 TCF7L2 HNF4A HNF4G HAND2 RNF111

3.12e-051387199M734
PathwayPID_HIF1_TFPATHWAY

GATA2 CITED2 HNF4A

9.00e-0566193M255
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS

HNF4A HNF4G

3.56e-0421192M14966
PathwayREACTOME_GENERIC_TRANSCRIPTION_PATHWAY

GATA2 CITED2 POU4F1 TCF7L2 HNF4A RNF111

3.77e-04768196MM14851
PathwayKEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG

HNF4A HNF4G

5.07e-0425192M18312
Pubmed

A census of human transcription factors: function, expression and evolution.

GATA2 FOXD2 SHOX POU4F1 POU4F3 OTX1 TCF7L2 RERE HNF4A HNF4G OLIG2 MEIS2 HAND2 TLX1

3.20e-14908331419274049
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

GATA2 CITED2 FOXD2 POU4F3 OTX1 TCF7L2 HNF4A HNF4G MEIS2 HAND2 RNF111

3.01e-11709331122988430
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

GATA2 FOXD2 SHOX POU4F1 POU4F3 OTX1 HNF4A OLIG2 MEIS2 HAND2

5.41e-11544331028473536
Pubmed

Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron fate and regulates differentiation of the dorsal midbrain into the inferior and superior colliculi.

GATA2 POU4F1 POU4F3 TCF7L2 MEIS2

5.42e-112833538344749
Pubmed

Tcf7l2 plays crucial roles in forebrain development through regulation of thalamic and habenular neuron identity and connectivity.

GATA2 POU4F1 TCF7L2 OLIG2

1.16e-074733428219675
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

POU4F3 OTX1 TCF7L2 HNF4A HNF4G MEIS2

1.65e-0726333620932939
Pubmed

Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina.

POU4F1 POU4F3 OLIG2

1.70e-071233321771810
Pubmed

Loss of Axin2 Causes Ocular Defects During Mouse Eye Development.

POU4F1 OTX1 TCF7L2

3.51e-071533327701636
Pubmed

Integral bHLH factor regulation of cell cycle exit and RGC differentiation.

POU4F1 POU4F3 OLIG2

3.51e-071533329770538
Pubmed

The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer.

GATA2 POU4F1 TCF7L2 MEIS2

7.78e-077533437298722
Pubmed

Three-dimensional interactions between enhancers and promoters during intestinal differentiation depend upon HNF4.

HNF4A HNF4G

8.73e-07233233503426
Pubmed

Intestine-specific ablation of the Hepatocyte Nuclear Factor 4a (Hnf4a) gene in mice has minimal impact on serum lipids and ileum gene expression profile due to upregulation of its paralog Hnf4g.

HNF4A HNF4G

8.73e-07233234973414
Pubmed

Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors.

HNF4A HNF4G

8.73e-07233221047794
Pubmed

Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4α at the protein level.

TCF7L2 HNF4A

8.73e-07233224463962
Pubmed

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids.

HNF4A HNF4G

8.73e-07233212220494
Pubmed

Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes.

HNF4A HNF4G

8.73e-0723328622695
Pubmed

POU4F3 Is Necessary for Normal Merkel Cell Formation, whereas POU4F1 Is Dispensable.

POU4F1 POU4F3

8.73e-07233239009281
Pubmed

Induction of Hepatic Metabolic Functions by a Novel Variant of Hepatocyte Nuclear Factor 4γ.

HNF4A HNF4G

8.73e-07233230224520
Pubmed

Glucose Tolerance Is Improved in Mice Invalidated for the Nuclear Receptor HNF-4γ: A Critical Role for Enteroendocrine Cell Lineage.

HNF4A HNF4G

8.73e-07233225829452
Pubmed

Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs.

POU4F1 POU4F3

8.73e-0723328248179
Pubmed

Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS.

GATA2 TCF7L2 OLIG2

1.18e-062233321775418
Pubmed

Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity.

GATA2 POU4F1 MEIS2

1.55e-062433324335253
Pubmed

Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons.

GATA2 POU4F1 OLIG2

1.76e-062533319088086
Pubmed

A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity.

HNF4A HNF4G

2.62e-06333230988513
Pubmed

The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac.

HNF4A HNF4G

2.62e-06333234001900
Pubmed

Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems.

POU4F1 POU4F3

2.62e-0633329598366
Pubmed

Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium.

TCF7L2 HNF4A

2.62e-06333219805521
Pubmed

Differential expression of Brn3 transcription factors in intrinsically photosensitive retinal ganglion cells in mouse.

POU4F1 POU4F3

2.62e-06333221935940
Pubmed

Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a.

POU4F1 POU4F3

2.62e-0633328290353
Pubmed

The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons.

POU4F1 POU4F3

2.62e-0633327623109
Pubmed

Systematic identification of intergenic long-noncoding RNAs in mouse retinas using full-length isoform sequencing.

POU4F1 POU4F3

2.62e-06333231286854
Pubmed

NONO enhances mRNA processing of super-enhancer-associated GATA2 and HAND2 genes in neuroblastoma.

GATA2 HAND2

2.62e-06333236416237
Pubmed

The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain.

POU4F1 POU4F3

2.62e-0633327935408
Pubmed

Missing optomotor head-turning reflex in the DBA/2J mouse.

POU4F1 GPNMB

2.62e-06333221757588
Pubmed

Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes.

POU4F1 POU4F3

2.62e-0633328162704
Pubmed

Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord.

GATA2 POU4F1 OLIG2

4.16e-063333325179941
Pubmed

Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers.

HNF4A HNF4G

5.23e-06433212544512
Pubmed

Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development.

POU4F1 POU4F3

5.23e-0643329256502
Pubmed

Identification of retinal ganglion cell types and brain nuclei expressing the transcription factor Brn3c/Pou4f3 using a Cre recombinase knock-in allele.

POU4F1 POU4F3

5.23e-06433233135183
Pubmed

Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.

TCF7L2 HNF4A

5.23e-06433220361036
Pubmed

Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3.

TCF7L2 HNF4A

5.23e-06433222951069
Pubmed

Morphologies of mouse retinal ganglion cells expressing transcription factors Brn3a, Brn3b, and Brn3c: analysis of wild type and mutant cells using genetically-directed sparse labeling.

POU4F1 POU4F3

5.23e-06433220826176
Pubmed

Genetic interactions between Brn3 transcription factors in retinal ganglion cell type specification.

POU4F1 POU4F3

5.23e-06433224116103
Pubmed

The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells.

MEIS2 TLX1

5.23e-06433216357834
Pubmed

Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons.

TCF7L2 OLIG2 MEIS2

7.51e-064033327657450
Pubmed

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes.

HNF4A HNF4G

8.72e-06533236924494
Pubmed

Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development.

POU4F1 POU4F3

8.72e-0653328637595
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

CITED2 FNDC3B OTX1 TCF7L2 RERE CHERP IQSEC2 RNF111

1.29e-05120333829180619
Pubmed

The Wilms' tumor gene Wt1 is required for normal development of the retina.

POU4F1 POU4F3

1.31e-05633211889045
Pubmed

MEIS proteins as partners of the TLX1/HOX11 oncoprotein.

MEIS2 TLX1

1.31e-05633219559479
Pubmed

Gfi1-Cre knock-in mouse line: A tool for inner ear hair cell-specific gene deletion.

POU4F1 POU4F3

1.31e-05633220533399
Pubmed

Loss of AP-2delta reduces retinal ganglion cell numbers and axonal projections to the superior colliculus.

POU4F1 POU4F3

1.31e-05633227259519
Pubmed

Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors.

POU4F1 POU4F3

1.31e-0563329630743
Pubmed

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.

TCF7L2 OLIG2

1.31e-05633226955760
Pubmed

POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells.

POU4F1 POU4F3

1.31e-0563328632990
Pubmed

Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus.

HNF4A HNF4G

1.31e-05633237399024
Pubmed

Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis.

POU4F1 POU4F3

1.31e-05633222262898
Pubmed

Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.

TCF7L2 HNF4A

1.31e-05633217601994
Pubmed

Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth.

POU4F1 POU4F3

1.31e-05633211807038
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

GATA2 POU4F1 RERE HNF4A HNF4G MEIS2 TLX1

1.53e-0587733720211142
Pubmed

Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression.

POU4F1 POU4F3 OLIG2

1.77e-055333327210758
Pubmed

Cited2, a coactivator of HNF4alpha, is essential for liver development.

CITED2 HNF4A

1.83e-05733217932483
Pubmed

Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells.

POU4F1 POU4F3

1.83e-0573329735355
Pubmed

Class I histone deacetylases in retinal progenitors and differentiating ganglion cells.

POU4F1 POU4F3

1.83e-05733230179675
Pubmed

Sumoylation is involved in beta-catenin-dependent activation of Tcf-4.

TCF7L2 HNF4A

1.83e-05733212727872
Pubmed

GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells.

HNF4A HNF4G

1.83e-05733222554936
Pubmed

Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates.

POU4F1 OLIG2

1.83e-05733222543161
Pubmed

Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development.

OTX1 TCF7L2

1.83e-05733217366625
Pubmed

Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain.

FOXD2 HNF4A HNF4G

2.20e-055733321122108
Pubmed

Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formation.

MEIS2 HAND2

2.44e-05833215069081
Pubmed

A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning.

TCF7L2 HNF4A

2.44e-05833214667415
Pubmed

Mutant Hoxd13 induces extra digits in a mouse model of synpolydactyly directly and by decreasing retinoic acid synthesis.

MEIS2 HAND2

3.13e-05933219075394
Pubmed

Otx1 and Otx2 activities are required for the normal development of the mouse inner ear.

POU4F3 OTX1

3.13e-05933210225993
Pubmed

Gut microbial fatty acid isomerization modulates intraepithelial T cells.

HNF4A HNF4G

3.13e-05933237380774
Pubmed

Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb.

MEIS2 HAND2

3.13e-05933232537491
Pubmed

Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice.

OLIG2 MEIS2

3.13e-05933227621227
Pubmed

Genetic chimeras reveal the autonomy requirements for Vsx2 in embryonic retinal progenitor cells.

POU4F1 OTX1

3.13e-05933225927996
Pubmed

Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube.

TCF7L2 OLIG2

3.13e-05933216950124
Pubmed

The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.

GATA2 TCF7L2 MEIS2 HAND2

3.18e-0519133424146773
Pubmed

Expression of the basic helix-loop-factor Olig2 in the developing retina: Olig2 as a new marker for retinal progenitors and late-born cells.

POU4F1 OLIG2

3.91e-051033216815098
Pubmed

The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes.

POU4F1 OTX1

3.91e-051033215872002
Pubmed

The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.

TCF7L2 HNF4A

3.91e-051033218498634
Pubmed

RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors.

POU4F1 POU4F3

3.91e-051033223805044
Pubmed

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS.

TCF7L2 OLIG2

3.91e-051033219515974
Pubmed

Essential role of Gata transcription factors in sympathetic neuron development.

GATA2 HAND2

4.78e-051133215329349
Pubmed

The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner.

CITED2 HAND2

4.78e-051133215576406
Pubmed

Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve.

POU4F1 OLIG2

4.78e-051133218650339
Pubmed

Spatio-temporal dynamics of gene expression of the Edn1-Dlx5/6 pathway during development of the lower jaw.

MEIS2 HAND2

4.78e-051133220333701
Pubmed

Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling.

POU4F1 POU4F3

4.78e-05113328876243
Pubmed

Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons.

POU4F1 POU4F3

4.78e-05113328955272
Pubmed

The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells.

POU4F1 POU4F3

4.78e-051133228009286
Pubmed

Hepatocyte nuclear factor 4alpha contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation.

HNF4A HNF4G

4.78e-051133219389805
Pubmed

Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon.

TCF7L2 OLIG2

4.78e-051133234222248
Pubmed

Molecular basis of pituitary dysfunction in mouse and human.

GATA2 OTX1

5.73e-051233211420609
Pubmed

Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons.

POU4F1 OLIG2

6.77e-051333224347548
Pubmed

T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor.

OLIG2 HAND2

6.77e-051333225760946
Pubmed

Meis2 controls skeletal formation in the hyoid region.

MEIS2 HAND2

6.77e-051333236247013
Pubmed

Genetic dissection of Gata2 selective functions during specification of V2 interneurons in the developing spinal cord.

GATA2 OLIG2

6.77e-051333225369423
Pubmed

Hox11 genes are required for regional patterning and integration of muscle, tendon and bone.

TCF7L2 TLX1

7.89e-051433224154528
Pubmed

GABAergic and glutamatergic identities of developing midbrain Pitx2 neurons.

GATA2 POU4F1

7.89e-051433221246650
InteractionKRTAP6-3 interactions

GATA2 FOXD2 POU4F3 OTX1 TCF7L2 MEIS2

2.19e-07161336int:KRTAP6-3
InteractionKRTAP11-1 interactions

GATA2 FNDC3B OTX1 CHERP MEIS2

8.48e-07108335int:KRTAP11-1
InteractionKRTAP22-1 interactions

FOXD2 OTX1 MEIS2

1.80e-0615333int:KRTAP22-1
InteractionPOU2AF1 interactions

GATA2 FOXD2 OTX1 MEIS2

2.06e-0656334int:POU2AF1
InteractionTLE5 interactions

GATA2 FOXD2 MED12L CSTF2 TCF7L2 HNF4A TLX1

6.16e-06443337int:TLE5
InteractionKDM6A interactions

GATA2 OGT RERE HNF4A TLX1

6.24e-06162335int:KDM6A
InteractionEMX1 interactions

HNF4G MEIS2 TLX1

8.98e-0625333int:EMX1
InteractionHIVEP1 interactions

GATA2 OTX1 OGT HNF4A TLX1

1.22e-05186335int:HIVEP1
InteractionKRTAP6-2 interactions

FOXD2 OTX1 TCF7L2 RERE MEIS2

1.25e-05187335int:KRTAP6-2
InteractionZNF608 interactions

GATA2 RERE HNF4A TLX1

1.57e-0593334int:ZNF608
InteractionKRTAP21-2 interactions

GATA2 FOXD2 TCF7L2

1.74e-0531333int:KRTAP21-2
InteractionTLE3 interactions

GATA2 CSTF2 TCF7L2 RERE CHERP TLX1

2.93e-05376336int:TLE3
InteractionKRTAP7-1 interactions

GATA2 OTX1 TCF7L2

3.25e-0538333int:KRTAP7-1
InteractionCREBBP interactions

GATA2 CITED2 TCF7L2 OGT HNF4A RNF111 TLX1

4.31e-05599337int:CREBBP
InteractionKRTAP19-2 interactions

FOXD2 OTX1 MEIS2

6.18e-0547333int:KRTAP19-2
InteractionKMT2C interactions

GATA2 OGT HNF4A TLX1

6.58e-05134334int:KMT2C
InteractionPAGR1 interactions

GATA2 HNF4A TLX1

7.90e-0551333int:PAGR1
InteractionKRTAP12-4 interactions

OTX1 RERE OLIG2

8.86e-0553333int:KRTAP12-4
InteractionZNF609 interactions

GATA2 RERE HNF4A TLX1

9.19e-05146334int:ZNF609
InteractionATXN1L interactions

GATA2 HSFX1 ZSWIM8 TLX1

1.02e-04150334int:ATXN1L
InteractionFAM168B interactions

CSTF2 OTX1 TCF7L2

1.16e-0458333int:FAM168B
InteractionKANSL2 interactions

OGT RERE HNF4A

2.03e-0470333int:KANSL2
InteractionSMARCD2 interactions

GATA2 OGT HNF4A TLX1

2.19e-04183334int:SMARCD2
InteractionNFIA interactions

GATA2 TCF7L2 HNF4A TLX1

2.43e-04188334int:NFIA
InteractionUBN1 interactions

TCF7L2 OGT HNF4A

2.69e-0477333int:UBN1
InteractionCUX1 interactions

GATA2 TCF7L2 HNF4A TLX1

3.02e-04199334int:CUX1
InteractionRING1 interactions

GATA2 OGT HNF4A TLX1

3.13e-04201334int:RING1
InteractionRNF4 interactions

CITED2 FNDC3B OTX1 TCF7L2 RERE CHERP HNF4A IQSEC2 RNF111

3.28e-041412339int:RNF4
InteractionPBX1 interactions

SHOX MEIS2 TLX1

3.61e-0485333int:PBX1
InteractionKANSL3 interactions

OGT RERE HNF4A

3.73e-0486333int:KANSL3
InteractionUSP54 interactions

CSTF2 FNDC3B OTX1 CHERP

3.83e-04212334int:USP54
InteractionPRR12 interactions

GATA2 HNF4A TLX1

3.99e-0488333int:PRR12
InteractionUBN2 interactions

TCF7L2 HNF4A TLX1

4.13e-0489333int:UBN2
InteractionTLE4 interactions

GATA2 OTX1 TLX1

4.55e-0492333int:TLE4
InteractionZNF703 interactions

GATA2 OGT TLX1

4.69e-0493333int:ZNF703
InteractionNCOA3 interactions

GATA2 HNF4A HNF4G TLX1

4.72e-04224334int:NCOA3
InteractionKAT8 interactions

OGT RERE HNF4A

5.00e-0495333int:KAT8
InteractionZEB2 interactions

GATA2 HNF4A TLX1

5.00e-0495333int:ZEB2
InteractionDPF1 interactions

GATA2 HNF4A TLX1

5.00e-0495333int:DPF1
InteractionDNTTIP1 interactions

GATA2 HNF4A TLX1

5.00e-0495333int:DNTTIP1
InteractionKANSL1 interactions

OGT RERE HNF4A

5.15e-0496333int:KANSL1
InteractionPBX2 interactions

SHOX MEIS2 TLX1

5.31e-0497333int:PBX2
InteractionNHLRC4 interactions

POU4F3 OTX1

5.36e-0421332int:NHLRC4
InteractionQSER1 interactions

GATA2 HNF4A TLX1

5.80e-04100333int:QSER1
InteractionKRTAP6-1 interactions

OTX1 TCF7L2 MEIS2

6.33e-04103333int:KRTAP6-1
InteractionPNRC1 interactions

HNF4A HNF4G

6.44e-0423332int:PNRC1
InteractionCIC interactions

GATA2 FOXD2 OTX1 CHERP HNF4A TLX1

6.95e-04673336int:CIC
InteractionPSMA3 interactions

GATA2 FNDC3B TCF7L2 RERE OLIG2

7.17e-04443335int:PSMA3
InteractionMIDEAS interactions

GATA2 HNF4A TLX1

7.26e-04108333int:MIDEAS
InteractionANKRD10 interactions

CSTF2 OTX1

7.62e-0425332int:ANKRD10
InteractionFAM199X interactions

ZSWIM8 OGT

7.62e-0425332int:FAM199X
InteractionFOXP1 interactions

GATA2 HNF4A IQSEC2 TLX1

7.79e-04256334int:FOXP1
InteractionARID3B interactions

GATA2 HNF4A TLX1

8.28e-04113333int:ARID3B
InteractionBCL7C interactions

GATA2 HNF4A TLX1

8.72e-04115333int:BCL7C
InteractionKRTAP19-7 interactions

FOXD2 OTX1 TCF7L2

9.16e-04117333int:KRTAP19-7
InteractionHMG20B interactions

GATA2 CHERP HNF4A

1.03e-03122333int:HMG20B
InteractionARID3A interactions

GATA2 HNF4A TLX1

1.03e-03122333int:ARID3A
InteractionASXL2 interactions

GATA2 OGT HNF4A TLX1

1.04e-03277334int:ASXL2
InteractionBCL7A interactions

GATA2 HNF4A TLX1

1.06e-03123333int:BCL7A
InteractionRBFOX2 interactions

FNDC3B OGT RERE CHERP

1.15e-03284334int:RBFOX2
InteractionTCF7L2 interactions

GATA2 TCF7L2 HNF4A TLX1

1.16e-03285334int:TCF7L2
InteractionMCCD1 interactions

FNDC3B MEIS2

1.17e-0331332int:MCCD1
InteractionRBBP5 interactions

GATA2 OGT RERE HNF4A

1.19e-03287334int:RBBP5
InteractionCXXC1 interactions

OGT RERE HNF4A

1.30e-03132333int:CXXC1
InteractionNOTO interactions

FOXD2 MEIS2

1.33e-0333332int:NOTO
InteractionSINHCAF interactions

GATA2 HNF4A TLX1

1.38e-03135333int:SINHCAF
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

GATA2 RERE

1.75e-041524282
GeneFamilyPOU class homeoboxes and pseudogenes

POU4F1 POU4F3

4.20e-0423242523
GeneFamilyNuclear hormone receptors

HNF4A HNF4G

1.91e-034924271
GeneFamilyPRD class homeoboxes and pseudogenes

SHOX OTX1

6.57e-0392242521
GeneFamilyBasic helix-loop-helix proteins

OLIG2 HAND2

9.28e-03110242420
CoexpressionBENPORATH_SUZ12_TARGETS

GATA2 FOXD2 SHOX POU4F1 PHLDB1 POU4F3 OTX1 OTOP3 GUCY1A2 OLIG2 HAND2 TLX1

1.47e-0910353212M9898
CoexpressionBENPORATH_PRC2_TARGETS

GATA2 FOXD2 SHOX POU4F1 POU4F3 OTX1 OTOP3 OLIG2 HAND2 TLX1

3.24e-096503210M8448
CoexpressionBENPORATH_ES_WITH_H3K27ME3

GATA2 FOXD2 SHOX POU4F1 PHLDB1 POU4F3 OTX1 OTOP3 OLIG2 HAND2 TLX1

4.45e-0811153211M10371
CoexpressionBENPORATH_EED_TARGETS

GATA2 FOXD2 SHOX POU4F1 POU4F3 OTX1 OTOP3 OLIG2 HAND2 TLX1

3.18e-0710593210M7617
CoexpressionTHEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN

CITED2 OGT RERE MEIS2 RASGRP2

7.76e-06227325M11234
CoexpressionNAKAJIMA_MAST_CELL

GATA2 GPNMB HDC

2.42e-0546323M389
CoexpressionGSE27859_MACROPHAGE_VS_CD11C_INT_F480_INT_DC_UP

GATA2 IQSEC2 RNF111 HDC

5.45e-05171324M8594
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3K27ME3

POU4F1 POU4F3 OTOP3 OLIG2 RASGRP2 TLX1

7.05e-05591326M2019
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3K27ME3

POU4F1 POU4F3 OTOP3 OLIG2 RASGRP2 TLX1

7.73e-05601326MM866
CoexpressionGSE8515_CTRL_VS_IL6_4H_STIM_MAC_DN

FOXD2 HNF4G MEIS2 IQSEC2

9.07e-05195324M5765
CoexpressionAtlasDevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_top-relative-expression-ranked_1000

CITED2 FOXD2 MED12L FNDC3B OGT HNF4A HDC RASGRP2

1.52e-05837308gudmap_developingKidney_e15.5_stage III -IV renal corpusc_1000
ToppCellCOVID-19-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

GATA2 MED12L MEIS2 HDC

5.26e-06156334159504d43421ee83b9ab484816333ae549c9c2fd
ToppCellCOVID-19-Mast_cells-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

GATA2 MED12L MEIS2 HDC

5.26e-06156334bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCellmild-Myeloid-Eosinophils|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

GATA2 OLIG2 MEIS2 HDC

6.26e-061633347c57d541a88e9afa079e95b8a6ecdea60a0c6aaa
ToppCellnucseq-Immune-Hematopoietic-Granulocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GATA2 MED12L MEIS2 HDC

6.57e-0616533437615622c736e43260c38016e7c9e565ac97a3e8
ToppCellnucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GATA2 MED12L MEIS2 HDC

6.57e-06165334640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCellnucseq-Immune-Hematopoietic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GATA2 MED12L MEIS2 HDC

6.57e-06165334f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCellsevere-Myeloid-Eosinophils|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

GATA2 OLIG2 MEIS2 HDC

7.39e-06170334863f0266d5837cdbc3e09a3fe6a99dd3e6261674
ToppCellmild-Myeloid-Eosinophils|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

GATA2 OLIG2 MEIS2 HDC

7.56e-061713345c8198182495bda7a826e9d80aa467f4eb1094ec
ToppCell10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

GATA2 CITED2 MEIS2 HDC

7.74e-061723347fb43b3938b9a3b6935ec22d9d853e7d47b82b3c
ToppCellImmune-mast_cell|World / Lineage, Cell type, age group and donor

GATA2 MED12L MEIS2 HDC

7.74e-061723346e8e0aac5a20dbc789bf8c6916833bb8709a411a
ToppCell3'_v3-bone_marrow-Mast|bone_marrow / Manually curated celltypes from each tissue

GATA2 MED12L MEIS2 HDC

9.26e-06180334b37ee81b792213d6595b4ec65d04bc35d83321c7
ToppCellsystemic_lupus_erythematosus-managed-Hematopoietic-progenitor_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

GATA2 MED12L MEIS2 HDC

9.46e-06181334070ae3f3fe0e177fabcf34e64a0f158b01354837
ToppCellcritical-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

GATA2 MEIS2 HDC LINC01558

9.46e-06181334f0d81ae74d3f32979624a94b2ef93774831a7970
ToppCellsystemic_lupus_erythematosus-managed-Hematopoietic-progenitor_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

GATA2 MED12L MEIS2 HDC

1.12e-051893346687a93ac8540ece5fd762f6f77c1f25f159195b
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GATA2 CITED2 MEIS2 HAND2

1.12e-051893348e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GATA2 CITED2 MEIS2 HAND2

1.12e-05189334fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GATA2 CITED2 MEIS2 HAND2

1.24e-05194334c5e77650d7abee339ec38fa78a622bb124db3fa5
ToppCell10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

GATA2 CITED2 MEIS2 HDC

1.27e-05195334f1f48e2e57b2282572959b152aad4bee05143f03
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-midbrain/hindbrain_cells|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

GATA2 CITED2 POU4F1 TCF7L2

1.29e-051963340767581b69bc7e6334d580ca02ed1e831b7b55da
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GATA2 CITED2 MEIS2 HAND2

1.29e-051963347d5eaed189aa6116f3799be010139fb675ec65e0
ToppCellMS-IIF-Others-HSPC|IIF / Disease, condition lineage and cell class

GATA2 MED12L MEIS2 HDC

1.37e-051993343384db80f6024bcabe2625f24d5f4e0d3d8caa7e
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Neuron|10w / Sample Type, Dataset, Time_group, and Cell type.

CITED2 FOXD2 POU4F1 RERE

1.40e-05200334332905a686356cd1e024d40679be98e9d8b1b5e8
ToppCellprimary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Rassf10|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PHLDB1 TCF7L2 OLIG2

4.75e-05953330ac6cba7e0ed6083f777287f39a871461fa1bca4
ToppCelllymphoid-T_cell-pro-T_cell|lymphoid / Lineage, cell class and subclass

GATA2 ZSWIM8 HDC

5.21e-05983334da11182885d5f2673e85bd9c5717939b0268427
ToppCellPBMC-Mild-Myeloid-Neutrophil-Neutrophil-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GATA2 GUCY1A2 HDC

6.96e-05108333c647f6595e7cccea91429a2377c9de6cc1acff4d
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Rassf10|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

POU4F1 TCF7L2 OLIG2

9.29e-05119333ec3af1253f03b3ec403f73243237acf08ad56789
ToppCellFetal_29-31_weeks-Immune-mast_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GATA2 MED12L HDC

1.32e-041343331d6e74612fd91a2ef9d14bf77262b2d08e1052ca
ToppCell10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor-common_myeloid_progenitor|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GATA2 MED12L HDC

1.41e-041373336d90da42dcc06aa895f920218055068f3c76d57d
ToppCellprimary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Grm5|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PHLDB1 TCF7L2 OLIG2

1.47e-04139333a957ea4e581646c76b16b6a7f89579b8c7ac35b6
ToppCellFetal_29-31_weeks-Immune-mast_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GATA2 MED12L HDC

1.67e-04145333dc89d817a9bef24a07e992efdab4136f12ceb399
ToppCellChildren_(3_yrs)-Immune-mast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

GATA2 MEIS2 HDC

1.70e-04146333f7349d63bb47f1f22ced8ff514edc1c11bc782e7
ToppCell356C-Myeloid-Mast_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

GATA2 MED12L HDC

1.77e-041483331668d8a9e680da335362744f36b05446c499347e
ToppCell356C-Myeloid-Mast_cell-|356C / Donor, Lineage, Cell class and subclass (all cells)

GATA2 MED12L HDC

1.77e-0414833318511ba10765eda937c5a710626361f7e6b9b321
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OGT OLIG2 HDC

1.77e-04148333ba277c898678dd36f8dc1d681301c71901b89055
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OGT OLIG2 HDC

1.77e-04148333b4632029ebd14969bda59a1bd1454eadb8efe563
ToppCellMyeloid-Myeloid-E_(Neutrophils)|Myeloid / shred on cell class and cell subclass (v4)

MED12L OGT HDC

1.84e-041503331bffb8d86b737ac43be902d9468041aef3542f1f
ToppCellChildren_(3_yrs)-Immune-mast_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

GATA2 MEIS2 HDC

1.88e-04151333bbf735c6433c3fc2feedb24ed6f48c51d545fb60
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_granulocytic|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GATA2 MEIS2 HDC

1.91e-0415233332634195048858ae84605c61e43c542d90f7cab5
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_granulocytic-mast_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GATA2 MEIS2 HDC

1.91e-041523330eb185b2404f015efff1bd140e0c502d714720fb
ToppCellAdult-Immune-mast_cell-D122|Adult / Lineage, Cell type, age group and donor

GATA2 MEIS2 HDC

2.03e-041553337c9de0591d1bf756b8e268b278bbe10bd5415dcd
ToppCellChildren_(3_yrs)-Immune-mast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

GATA2 MEIS2 HDC

2.11e-04157333ec185dbeabb67fd9ca85f71cab88463b60f9b1c1
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic-mast_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GATA2 MEIS2 HDC

2.19e-04159333ecd1daa33549541aee3bf4e139ab6732efc8e74c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GUCY1A2 MEIS2 RASGRP2

2.19e-041593332607b562903228274fbd96168ba826782fab0b53
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GUCY1A2 MEIS2 RASGRP2

2.19e-04159333e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GATA2 MEIS2 HDC

2.19e-041593337b6370c9567da7d40541c6e243efa704ed7e90ae
ToppCellNS-critical-d_16-33-Myeloid-Mast_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GATA2 HDC LINC01558

2.23e-04160333c61869d9dbba250270e59366e15af204e5b4395d
ToppCellAdult-Immune-mast_cell|Adult / Lineage, Cell type, age group and donor

GATA2 MEIS2 HDC

2.27e-0416133344f5c0256b3ce264a6c7b62740f32dcd45ee052d
ToppCellChildren_(3_yrs)-Immune-dendritic_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MED12L POU4F1 OTX1

2.27e-04161333cd41abb7ae659d3d314281783a0aaad562b26037
ToppCellFetal_29-31_weeks-Immune-mast_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GATA2 MED12L HDC

2.35e-0416333303b2ec226adffba3ce893f3d12e549c841e662fd
ToppCellIIF-Other-HSPC|IIF / Disease, Lineage and Cell Type

GATA2 MED12L HDC

2.35e-041633331e0d38fbed38ac48478868a1480172a1a3f7c1b7
ToppCell356C-Myeloid-Mast_cell|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

GATA2 MEIS2 HDC

2.39e-04164333b3192c443f4848e6a8afdb89c155f9ec42a154b0
ToppCell356C-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

GATA2 MEIS2 HDC

2.39e-04164333f7288ec4daf494dae770ea6c58bead27660ccae1
ToppCellfacs-Kidney-nan-24m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXD2 OTX1 GUCY1A2

2.44e-04165333c746bb22ef52d7f7fa6ee9c37ae6bbe0ccce718e
ToppCellfacs-Kidney-nan-24m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXD2 OTX1 GUCY1A2

2.44e-041653334cdd80580d5638fd649280ba3893251c2f898f3f
ToppCellmoderate-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

GATA2 MEIS2 HDC

2.48e-04166333c3835b424c63bf11a4e2c47635dc3787fc4a637a
ToppCellremission-HSPC|World / disease stage, cell group and cell class

GATA2 MED12L HDC

2.48e-04166333d269ee6f7adb55b05dcb5eaea96629ccb0b2d6e3
ToppCellTCGA-Colorectal|World / Sample_Type by Project: Shred V9

FOXD2 HNF4A HNF4G

2.48e-04166333c018cd8c7a82251c67e3dc812d4d21e527a43456
ToppCell343B-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

GATA2 MEIS2 HDC

2.48e-041663334e47e7f3019fb2dcbc35b4e9b47ee265a97cec5c
ToppCell10x3'2.3-week_14-16-Hematopoietic-erythroid-late_erythroid|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

GATA2 MEIS2 HDC

2.48e-04166333b4e5466a33578103d197cf67f37e7ec88e09281f
ToppCellwk_20-22-Hematologic-Myeloid-Mast|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

GATA2 MEIS2 HDC

2.48e-04166333004ab6a1425d812c7ce572205875fd702d4a9659
ToppCellPosterior_cortex-Macroglia-POLYDENDROCYTE|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PHLDB1 TCF7L2 OLIG2

2.48e-04166333a7ac5a414e3e2ff01f1c452c0a85048b17cba0b6
ToppCell343B-Myeloid-Mast_cell|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

GATA2 MEIS2 HDC

2.48e-04166333f6e2ec767c022982ef416fadb998a7b6b958f76a
ToppCell10x5'-lymph-node_spleen-Mast-Mast_cells|lymph-node_spleen / Manually curated celltypes from each tissue

GATA2 MEIS2 HDC

2.57e-04168333650ad3ea52577887885d82457dbc04202ce3eb34
ToppCellBronchial_Biopsy-Immune-Mast_cells|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

GATA2 MEIS2 HDC

2.57e-0416833345ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCellASK428-Immune-Mast_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

GATA2 MEIS2 HDC

2.57e-04168333c399fcb4d1d0be48026c2ecabc34a5935e7adf73
ToppCell10x5'-lymph-node_spleen-Mast|lymph-node_spleen / Manually curated celltypes from each tissue

GATA2 MEIS2 HDC

2.57e-04168333e58ffbb57c81967766755c3f6f347b158a39cb0d
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|356C / Donor, Lineage, Cell class and subclass (all cells)

GATA2 MEIS2 LINC01558

2.61e-04169333337be3bf485b54afad86e256cb0c4c1d0c2a9a2a
ToppCellControl-Mast_cells|Control / group, cell type (main and fine annotations)

GATA2 MED12L HDC

2.61e-04169333fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|356C / Donor, Lineage, Cell class and subclass (all cells)

GATA2 MEIS2 LINC01558

2.61e-04169333605cc2638271803cf1d972ab3fa8f13f89666376
ToppCellwk_15-18-Hematologic-Meg-ery-Megakaryocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GATA2 MED12L RASGRP2

2.61e-04169333d571e84e01e3316748d4407ed98881b17484e035
ToppCell10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

GATA2 MEIS2 HDC

2.61e-0416933360fd3d06c5f61c1f021329d18b3bc605dda4af07
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

GATA2 MEIS2 HDC

2.61e-04169333f68195510b91e287fe1507455ca067ece77a3897
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PHLDB1 TCF7L2 OLIG2

2.61e-0416933350cc0f5a022b95986949db63208a627cef9f4a69
ToppCellCOVID-19-lung-MAST|lung / Disease (COVID-19 only), tissue and cell type

GATA2 MEIS2 HDC

2.66e-04170333e90f18e5462381b38e918442b38b1c8105291908
ToppCellControl-Myeloid-Mast|Control / Disease state, Lineage and Cell class

GATA2 MEIS2 HDC

2.66e-041703339a14deb7f7cd4a49c217eba4023f7bf1dec6c902
ToppCellCOVID-19_Convalescent-Hematopoietic_SC|COVID-19_Convalescent / Disease group, lineage and cell class

GATA2 MED12L HDC

2.66e-041703338a73d5334eed1cd9fdcc3ebeae0bdf9f945c228a
ToppCellControl-Mast_cells-Mast_cells|Control / group, cell type (main and fine annotations)

GATA2 MED12L HDC

2.66e-04170333c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell3'_v3-bone_marrow-Mast-Mast_cell_lympho|bone_marrow / Manually curated celltypes from each tissue

GATA2 MED12L HDC

2.66e-041703334dedf482cd4521b3f87d2b5ae80f7a3ea8686a15
ToppCellPBMC-Convalescent-Hematopoietic-HSPC|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GATA2 MED12L HDC

2.71e-04171333172db31a37b72fb87fe5f0f79da51866b90dd1ad
ToppCellwk_20-22-Hematologic-Myeloid-Eosinophil|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

GATA2 MEIS2 HDC

2.71e-04171333fa6e856e62b82ec4972e0098e73f237cc611891f
ToppCellPBMC-Convalescent-Hematopoietic-HSPC-HSPC|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GATA2 MED12L HDC

2.71e-041713332031797d579ce373921affad70da6e50eec13664
ToppCellcontrol-Myeloid-Eosinophils|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

GATA2 MEIS2 HDC

2.71e-0417133382f736c33ed96c0865618e8f8eb82a5487126bdc
ToppCellControl-Myeloid-Mast|World / Disease state, Lineage and Cell class

GATA2 MEIS2 HDC

2.71e-04171333ed8e61d524f4cddc6084b261175df54d2a64a60f
ToppCellremission-HSPC|remission / disease stage, cell group and cell class

GATA2 MED12L HDC

2.71e-0417133341b424e58470a2fc25632aea50a37c7c5ea17645
ToppCellPBMC-Convalescent-Hematopoietic-HSPC-HSPC-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GATA2 MED12L HDC

2.71e-04171333a4e13b304ef414722ffdc06560deeab41785e956
ToppCellMyeloid-Myeloid-D_(Mast_cell)|Myeloid / shred on cell class and cell subclass (v4)

GATA2 MEIS2 HDC

2.71e-041713335f1aafc4c55a9c6c3153430186a8a351425a3cb9
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CITED2 TCF7L2 GPNMB

2.75e-04172333c8ea80042faf923b08ff03d73100533d521d73ef
ToppCellPBMC-Convalescent-Hematopoietic-HSPC-HSPC-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GATA2 MED12L HDC

2.75e-041723338fd3db757d54949bd583d5f0eadf63a32342cb9d
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

GATA2 MEIS2 HDC

2.75e-041723333a76cfb2832790144a6da6406469ead0767916b5
ToppCellILEUM-inflamed-(4)_Mast|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

GATA2 OTX1 HDC

2.75e-04172333be82f749f4b1049ae8832facc052082cf5463c11
ToppCell3'_v3-blood-Mast|blood / Manually curated celltypes from each tissue

GATA2 MED12L HDC

2.75e-04172333e7a46bbeff749ca59b9f1357409ce1ad59dd22dd
ToppCellPBMC-Convalescent-Hematopoietic-HSPC-HSPC|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

GATA2 MED12L HDC

2.75e-04172333382cb5fea099110eb026a8bba6cf4c28763ea52f
ToppCellILEUM-inflamed-(4)_Mast_cells|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

GATA2 OTX1 HDC

2.75e-041723337185b28282412f3a464b2a8ad5605475a1a31358
ToppCellPBMC-Convalescent-Hematopoietic-HSPC|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

GATA2 MED12L HDC

2.75e-04172333da78f7a71b7f05c5c484c9ed19ba37c55d35e870
ToppCell10x3'2.3-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

GATA2 MEIS2 HDC

2.80e-041733331e4afa020fae682521335b440ccd33c16f37156f
ToppCell368C-Myeloid-Mast_cell|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

GATA2 MEIS2 HDC

2.80e-041733338cffb4a37d30b6626188309b868ac4a62e91262f
ToppCell368C-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

GATA2 MEIS2 HDC

2.80e-04173333fb87ea74bf70aa83b458edf728c81857c8b8eb96
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FOXD2 HNF4A HNF4G

2.80e-0417333381c36b9fe02c59099f080b2db02f4eaf2783911f
ToppCell10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

GATA2 MEIS2 HDC

2.85e-0417433364d13a7a9757e85f4f4af876c687dd18a7efa01a
ToppCell10x5'-GI_small-bowel-Mast|GI_small-bowel / Manually curated celltypes from each tissue

GATA2 MEIS2 HDC

2.85e-04174333e94c980b25edfd0e8598c416828801fcc00e8ead
Drugindomethacin, USP; Up 200; 20uM; MCF7; HG-U133A

PHLDB1 TCF7L2 RERE CHERP HDC

8.13e-06193335262_UP
DrugTetracycline hydrochloride [64-75-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A

GATA2 POU4F1 PHLDB1 TCF7L2 IQSEC2

9.43e-061993352243_DN
Diseasematurity-onset diabetes of the young type 1 (implicated_via_orthology)

HNF4A HNF4G

9.99e-072302DOID:0111099 (implicated_via_orthology)
DiseaseFanconi syndrome (implicated_via_orthology)

HNF4A HNF4G

5.99e-064302DOID:1062 (implicated_via_orthology)
Diseasematurity-onset diabetes of the young (implicated_via_orthology)

HNF4A HNF4G

4.47e-0510302DOID:0050524 (implicated_via_orthology)
DiseaseTetralogy of Fallot

CITED2 HAND2

1.19e-0416302C0039685
Diseasecorneal hysteresis

FNDC3B TCF7L2

1.88e-0420302EFO_0010066
DiseaseLeft Ventricle Remodeling

TCF7L2 HAND2

2.07e-0421302C0600520
DiseaseVentricular Remodeling

TCF7L2 HAND2

2.07e-0421302C0600519
Diseasesex interaction measurement, body mass index, age at assessment

TCF7L2 HNF4G

2.49e-0423302EFO_0004340, EFO_0008007, EFO_0008343
DiseaseTYPE 2 DIABETES MELLITUS

TCF7L2 HNF4A

3.72e-0428302125853
DiseaseType 2 diabetes mellitus

TCF7L2 HNF4A

3.72e-0428302cv:C0011860
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

FNDC3B TCF7L2 RERE HNF4G

4.84e-04364304EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Diseasebrain infarction (biomarker_via_orthology)

GPNMB MEIS2

5.17e-0433302DOID:3454 (biomarker_via_orthology)
DiseaseCongenital Heart Defects

MEIS2 HAND2

9.21e-0444302C0018798
Diseaseobesity (implicated_via_orthology)

MED12L TCF7L2 HNF4A

1.34e-03215303DOID:9970 (implicated_via_orthology)
Diseasebehavior

GUCY1A2 MEIS2

1.44e-0355302GO_0007610
Diseasebody fat percentage

FNDC3B TCF7L2 RERE HNF4G

1.44e-03488304EFO_0007800

Protein segments in the cluster

PeptideGeneStartEntry
SHHNVFPDGKPFPHH

GPNMB

151

Q14956
HQGPPMHHVPGHESR

CSTF2

351

P33240
MLGLPEHFLHHHPSS

HDC

126

P19113
PHMGAHPATAPFHLH

OTOP3

321

Q7RTS5
GLLGGSAHPHPHMHS

POU4F1

181

Q01851
SAHPHPHMHSLGHLS

POU4F1

186

Q01851
PHMHSLGHLSHPAAA

POU4F1

191

Q01851
QHHLLLYHTHPMPKP

MED12L

1706

Q86YW9
APSPSPMHSHHHRAF

RASGRP2

561

Q7LDG7
HGPPMHSYLPSHPHH

MEIS2

421

O14770
ASAPPVGPHRHFHAH

IQSEC2

1311

Q5JU85
DAPHAHHPLHPHLMQ

HNF4A

381

P41235
HHPLHPHLMQEHMGT

HNF4A

386

P41235
HLPTHPHLPTHPMMS

GOLGA6L6

26

A8MZA4
NDGSHLHHPMHPHLS

HNF4G

331

Q14541
LHHPMHPHLSQDPLT

HNF4G

336

Q14541
HSHHHPHQLSPMAPS

OTX1

256

P32242
PMAPSSMAGHHHHHP

OTX1

266

P32242
MSLVGGFPHHPVVHH

HAND2

1

P61296
HMAPVGHLPPFSHSG

GATA2

436

P23769
MGTAVGPHHSPAPHD

LINC01558

1

Q9Y6Z2
EMGPPHHHPGHRMPH

CHERP

581

Q8IWX8
AMSPTHHLPPYLTHH

FNDC3B

116

Q53EP0
HPHHSMLYPLSHGFR

OGT

506

O15294
FMLSPCHMHHHPGHV

INE1

16

O15225
PHPHPHPHAFAFAAA

FOXD2

286

O60548
PEGTLMLHYFHPHHI

GUCY1A2

231

P33402
ASMVMFPHLPALHHH

HSFX1

381

Q9UBD0
PHLHPHLAAHAPYLM

SHOX

226

O15266
PPPHHHVSAMGAGSL

OLIG2

301

Q13516
PLHPAANPMEHFARH

RERE

1336

Q9P2R6
WLHGHPHMHGGHLPS

RERE

1536

Q9P2R6
PAQIHPHHLGAMGHL

POU4F3

141

Q15319
HHHPAHRMGMGQFPS

CITED2

21

Q99967
HRMGMGQFPSPHHHQ

CITED2

26

Q99967
PNYGHGHHIHVPQTM

RNF111

781

Q6ZNA4
SRFPPHMVPPHHTLH

TCF7L2

291

Q9NQB0
SGFPPLMHHSILHHL

PHLDB1

1081

Q86UU1
YLTHPAHPAHPMPHM

ZSWIM8

1521

A7E2V4
MEHLGPHHLHPGHAE

TLX1

1

P31314