Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K9 demethylase activity

KDM3B KDM3A JMJD1C

1.53e-0714163GO:0032454
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM3B KDM3A JMJD1C

1.37e-0628163GO:0141052
GeneOntologyMolecularFunctionhistone demethylase activity

KDM3B KDM3A JMJD1C

1.87e-0631163GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

KDM3B KDM3A JMJD1C

2.06e-0632163GO:0140457
GeneOntologyMolecularFunctiondemethylase activity

KDM3B KDM3A JMJD1C

5.48e-0644163GO:0032451
GeneOntologyMolecularFunctionhistone H3K9me/H3K9me2 demethylase activity

KDM3B KDM3A

6.01e-065162GO:0140683
GeneOntologyMolecularFunctiondioxygenase activity

KDM3B KDM3A JMJD1C

6.13e-0598163GO:0051213
GeneOntologyMolecularFunctionchromatin DNA binding

KDM3B KDM3A JMJD1C

2.97e-04167163GO:0031490
GeneOntologyMolecularFunctionhistone modifying activity

KDM3B KDM3A JMJD1C

7.47e-04229163GO:0140993
GeneOntologyMolecularFunctiontranscription coregulator activity

KDM3B KDM3A SUB1 JMJD1C

8.63e-04562164GO:0003712
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

KDM3B KDM3A

1.22e-0365162GO:0016706
GeneOntologyMolecularFunctionchromatin binding

KDM3B KDM3A JMJD1C CHD3

2.37e-03739164GO:0003682
GeneOntologyBiologicalProcesschromatin remodeling

KDM3B UBR5 KDM3A ZNF726 JMJD1C CHD3

1.24e-05741166GO:0006338
GeneOntologyBiologicalProcesschromatin organization

KDM3B UBR5 KDM3A ZNF726 JMJD1C CHD3

3.64e-05896166GO:0006325
GeneOntologyBiologicalProcessprotein-DNA complex organization

KDM3B UBR5 KDM3A ZNF726 JMJD1C CHD3

6.70e-05999166GO:0071824
GeneOntologyCellularComponenthistone deacetylase complex

KDM3B KDM3A JMJD1C CHD3

4.46e-0785164GO:0000118
DomainJmjC

KDM3B KDM3A JMJD1C

1.03e-0624163PF02373
DomainJMJC

KDM3B KDM3A JMJD1C

2.52e-0632163PS51184
DomainJmjC_dom

KDM3B KDM3A JMJD1C

2.52e-0632163IPR003347
DomainJmjC

KDM3B KDM3A JMJD1C

2.77e-0633163SM00558
DomainZnf_FYVE_PHD

KDM3A CHD3

6.87e-03147162IPR011011
Domain-

SULT2B1 SLFN13 CHD3

2.41e-027461633.40.50.300
PathwayWP_THERMOGENESIS

RPS6KA6 KDM3B KDM3A

9.15e-05108123M39746
PathwayREACTOME_HDMS_DEMETHYLATE_HISTONES

KDM3B KDM3A

2.66e-0429122MM14934
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KDM3B KDM3A CHD3

3.81e-04175123MM14941
PathwayKEGG_MEDICUS_REFERENCE_ADRB3_UCP1_SIGNALING_PATHWAY

KDM3B KDM3A

3.89e-0435122M47969
PathwayREACTOME_HDMS_DEMETHYLATE_HISTONES

KDM3B KDM3A

7.95e-0450122M27232
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KDM3B KDM3A CHD3

1.37e-03272123M29619
PathwayWP_THYROID_HORMONES_PRODUCTION_AND_PERIPHERAL_DOWNSTREAM_SIGNALING_EFFECTS

RPS6KA6 KDM3B

2.72e-0393122M39791
Pubmed

Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation.

KDM3B KDM3A JMJD1C

3.19e-10416323593242
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

KIAA1671 KDM3B KDM3A SUB1 PRRC2A JMJD1C

1.05e-0754916638280479
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

KDM3B UBR5 KDM3A SUB1 PRRC2A JMJD1C CHD3

2.82e-07110316734189442
Pubmed

SUB1 promotes colorectal cancer metastasis by activating NF-κB signaling via UBR5-mediated ubiquitination of UBXN1.

UBR5 SUB1

5.95e-07316238240906
Pubmed

JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor.

KDM3B KDM3A

1.19e-06416216603237
Pubmed

Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis.

KDM3B KDM3A

1.19e-06416229526734
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

KDM3B KDM3A JMJD1C

1.45e-064916334368113
Pubmed

H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline.

KDM3B KDM3A

2.97e-06616232679061
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

KDM3B KDM3A SUB1 JMJD1C CHD3

5.98e-0660816536089195
Pubmed

The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin.

UBR5 SUB1

7.13e-06916230508113
Pubmed

BMI1-UBR5 axis regulates transcriptional repression at damaged chromatin.

UBR5 SUB1

1.54e-051316227647897
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

KDM3B KDM3A SUB1 PRRC2A CHD3

1.92e-0577416515302935
Pubmed

Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability.

PRRC2A TARS3 CACNG1

2.28e-0512216331615875
Pubmed

KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.

KDM3B KDM3A SUB1

2.76e-0513016335545047
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

KIAA1671 UBR5 JMJD1C CHD3

3.34e-0541816434709266
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

KIAA1671 KDM3B SUB1 PRRC2A CHD3

4.72e-0593416533916271
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

KDM3B KDM3A CHD3

4.84e-0515716330186101
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KDM3B KDM3A

1.04e-043316226864203
Pubmed

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.

KDM3B UBR5

1.10e-043416230894540
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

KDM3B UBR5 UNC80

1.41e-0422516312168954
Pubmed

Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.

KDM3B KDM3A

1.86e-044416224183668
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

KDM3B JMJD1C CHD3

2.35e-0426816333640491
Pubmed

Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures.

KDM3B KDM3A

2.70e-045316236265442
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

SUB1 JMJD1C CHD3

2.76e-0428316330585729
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

RPS6KA6 KDM3B SULT2B1 KDM3A

2.87e-0473016434857952
Pubmed

New nomenclature for chromatin-modifying enzymes.

KDM3B KDM3A

3.12e-045716218022353
Pubmed

Global phosphoproteome of HT-29 human colon adenocarcinoma cells.

UBR5 PRRC2A

3.34e-045916216083285
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

KIAA1671 KDM3B UBR5 SLFN13

3.63e-0477716435844135
Pubmed

Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.

UBR5 PRRC2A

4.18e-046616224811749
InteractionCEBPA interactions

KDM3B UBR5 KDM3A SUB1 PRRC2A JMJD1C CHD3

2.36e-051245167int:CEBPA
GeneFamilyPHD finger proteins|Lysine demethylases

KDM3B KDM3A JMJD1C

2.45e-0724103485
CoexpressionBOYAULT_LIVER_CANCER_SUBCLASS_G3_UP

UBR5 KDM3A SUB1

1.96e-04190163M18436
CoexpressionGSE11864_CSF1_VS_CSF1_PAM3CYS_IN_MAC_UP

KDM3B KDM3A JMJD1C

2.18e-04197163M3136
CoexpressionGSE46242_CTRL_VS_EGR2_DELETED_TH1_CD4_TCELL_UP

KIAA1671 PRRC2A CHD3

2.24e-04199163M9705
CoexpressionGSE27786_CD4_TCELL_VS_NEUTROPHIL_UP

KDM3A SLFN13 TARS3

2.28e-04200163M4830
CoexpressionGSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_UP

RPS6KA6 SULT2B1 UBR5

2.28e-04200163M5703
CoexpressionGSE43955_1H_VS_10H_ACT_CD4_TCELL_DN

SULT2B1 KDM3A PRRC2A

2.28e-04200163M9659
CoexpressionGSE44732_UNSTIM_VS_IL27_STIM_IMATURE_DC_UP

KIAA1671 SUB1 PRRC2A

2.28e-04200163M9699
CoexpressionGSE27786_LSK_VS_ERYTHROBLAST_UP

RPS6KA6 SLFN13 CHD3

2.28e-04200163M4757
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPS6KA6 SULT2B1 CHD3

2.34e-051591631baf0eaf9684668146a63192e77eec6c3c7a37f8
ToppCellwk_20-22-Epithelial-Proximal_epithelial-basal_late|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

RPS6KA6 SULT2B1 UNC80

3.28e-0517816303f22485074b3cbf9a6ad4d543c5bbfa826dc741
ToppCell343B-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SORCS2 KDM3A TARS3

3.68e-0518516302cbf492bc40abebaa93a3a208888afae72fbe06
ToppCell343B-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SORCS2 KDM3A TARS3

3.68e-051851631b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCellrenal_medulla_nuclei-Adult_normal_reference|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

SORCS2 SULT2B1 JMJD1C

3.99e-05190163f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ComputationalNeighborhood of ATRX

KDM3B SULT2B1 CHD3

2.60e-0421573MORF_ATRX
Diseasealcohol use disorder (implicated_via_orthology)

KDM3B KDM3A JMJD1C

1.49e-04195163DOID:1574 (implicated_via_orthology)
Diseaseinterleukin 10 measurement

SORCS2 JMJD1C

8.08e-0478162EFO_0004750
DiseaseGlobal developmental delay

KDM3B CHD3

2.32e-03133162C0557874
Diseaseattention function measurement

SORCS2 RPS6KA6

2.86e-03148162EFO_0007636
Diseaselung non-small cell carcinoma (is_marker_for)

KDM3B UBR5

3.71e-03169162DOID:3908 (is_marker_for)
Diseaseinsulin measurement

ZNF726 JMJD1C

9.00e-03267162EFO_0004467

Protein segments in the cluster

PeptideGeneStartEntry
RMPRNPWESCMDAEP

CACNG1

206

Q06432
RPEMGSWLGRDPPDM

KIAA1671

651

Q9BY89
LKDWPSGEDFKTMMP

JMJD1C

2261

Q15652
KDWPPGEDFRDMMPT

KDM3B

1486

Q7LBC6
MLPFAPQDEPWDREM

RPS6KA6

1

Q9UK32
KDWPPGEDFRDMMPS

KDM3A

1046

Q9Y4C1
RWSMPELMPDPSADS

CHD3

1511

Q12873
WVEKMMDADPEFPPD

SLFN13

346

Q68D06
SLMDFGEPWKMNPGD

TARS3

601

A2RTX5
MRGMPTFPWDEDPEE

SULT2B1

301

O00204
DWDYLRPPSMDMNGK

SORCS2

476

Q96PQ0
SSMEPWMEPLSPFED

PRRC2A

1626

P48634
REYWMDPEGEMKPGR

SUB1

86

P53999
EMFLGMPSEFPWGDE

UNC80

2171

Q8N2C7
EPWNMKRDEMVDEPP

ZNF726

61

A6NNF4
PMAKDCMGGIRDPDW

UBR5

821

O95071