Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH3 DYNC2H1 HTT	1.22e-04	37	52	3	GO:0045505
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNAH3 DYNC2H1 STARD9 MYO16	2.52e-04	118	52	4	GO:0003774
Domain	ATPase_dyneun-rel_AAA	DNAH3 DYNC2H1	6.51e-04	14	51	2	IPR011704
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DYNC2H1	6.51e-04	14	51	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DYNC2H1	6.51e-04	14	51	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DYNC2H1	6.51e-04	14	51	2	IPR013602
Domain	DHC_N2	DNAH3 DYNC2H1	6.51e-04	14	51	2	PF08393
Domain	MT	DNAH3 DYNC2H1	6.51e-04	14	51	2	PF12777
Domain	AAA_8	DNAH3 DYNC2H1	6.51e-04	14	51	2	PF12780
Domain	AAA_5	DNAH3 DYNC2H1	6.51e-04	14	51	2	PF07728
Domain	DHC_fam	DNAH3 DYNC2H1	7.50e-04	15	51	2	IPR026983
Domain	Dynein_heavy_dom	DNAH3 DYNC2H1	7.50e-04	15	51	2	IPR004273
Domain	Dynein_heavy	DNAH3 DYNC2H1	7.50e-04	15	51	2	PF03028
Domain	HEAT_REPEAT	COPG2 HEATR5B HTT	9.23e-04	70	51	3	PS50077
Domain	ARM-like	PLAA COPG2 HEATR5B HTT	6.27e-03	270	51	4	IPR011989
Domain	AAA+_ATPase	DNAH3 DYNC2H1 ABCC2	7.13e-03	144	51	3	IPR003593
Domain	AAA	DNAH3 DYNC2H1 ABCC2	7.13e-03	144	51	3	SM00382
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	TUBGCP3 COPG2 AKAP13 HTT	1.83e-05	104	52	4	31240132
Pubmed	Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued.	PRICKLE1 HTT	3.28e-05	6	52	2	18922795
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	GPHN STARD9 RTL9 HEATR5B	8.27e-05	153	52	4	10718198
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	GPHN PLAA RIPK1 PMPCA TUBGCP3 COPG2 CCDC93	1.25e-04	754	52	7	33060197
Pubmed	A shared vesicular carrier allows synaptic corelease of GABA and glycine.	GPHN RIMS2	1.43e-04	12	52	2	16701208
Pubmed	SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I.	POLR1A TEX11	1.69e-04	13	52	2	30746471
Pubmed	Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.	OR1J1 OR7A10	1.97e-04	14	52	2	7528109
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH3 DYNC2H1	1.97e-04	14	52	2	9373155
Pubmed	A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34.	TUBGCP3 MYO16	2.27e-04	15	52	2	16565260
Pubmed	Setd1b, encoding a histone 3 lysine 4 methyltransferase, is a maternal effect gene required for the oogenic gene expression program.	SETD1B BCL9	2.27e-04	15	52	2	28619824
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	PLAA PMPCA TUBGCP3 COPG2	2.89e-04	212	52	4	33462405
Pubmed	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.	GPHN GRIN2A	3.30e-04	18	52	2	28864826
Pubmed	Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis.	POLR1A TEX11	4.52e-04	21	52	2	30272023
Pubmed	Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.	PLAA IFNA5	4.97e-04	22	52	2	20574843
Pubmed	Gamma protocadherins are required for survival of spinal interneurons.	GPHN GRIN2A	6.96e-04	26	52	2	12467588
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	DCAF6 TOPAZ1 RTL9	7.09e-04	116	52	3	21282530
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	HROB RTL9 TUBGCP3 AFF4	8.32e-04	281	52	4	24163370
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	PNPLA2 SEPHS1 PMPCA DYNC2H1 COG7 COPG2 TMED2	9.74e-04	1061	52	7	33845483
Pubmed	Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse.	OR1J1 OR7A10	1.12e-03	33	52	2	17350283
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	DCAF6 DYNC2H1 COPG2 AKAP13 TMED2 MYO16	1.26e-03	807	52	6	30575818
Interaction	PHYHIP interactions	PNPLA2 COG7 ANKRD12 HTT	5.53e-06	47	50	4	int:PHYHIP
Cytoband	1p31.2	DEPDC1 PTGER3	1.26e-05	5	52	2	1p31.2
Drug	Cytisine (-) [485-35-8]; Down 200; 21uM; MCF7; HT_HG-U133A	SETD1B PLAA DYNC2H1 MAMLD1 AKAP13 CCDC93	5.68e-06	197	52	6	6217_DN
Drug	Oxantel pamoate [68813-55-8]; Down 200; 6.6uM; MCF7; HT_HG-U133A	ATRN TUBGCP3 AKAP13 MANEA AFF4 HTT	5.85e-06	198	52	6	5338_DN
Disease	Saldino-Noonan Syndrome	C2CD3 DYNC2H1	2.63e-04	14	51	2	C0036069
Disease	Pseudopelade	MBTPS2 ABCC2	4.92e-04	19	51	2	C0086873
Disease	Huntington's disease (is_implicated_in)	GRIN2A HTT	7.24e-04	23	51	2	DOID:12858 (is_implicated_in)
Disease	migraine disorder, pulse pressure measurement	DYNC2H1 C1D	9.27e-04	26	51	2	EFO_0005763, MONDO_0005277
Disease	Polydactyly	C2CD3 MBTPS2 DYNC2H1	1.10e-03	117	51	3	C0152427
Disease	Epileptic encephalopathy	GPHN PLAA	1.24e-03	30	51	2	C0543888
Disease	Drug Allergy	ABCC2 PTGER3	1.68e-03	35	51	2	C0013182

Protein segments in the cluster

Peptide	Gene	Start	Entry
SAKLTGMQNSLMMLV	COG7	151	P83436
LMKTNLKQMDSLMPL	AKAP13	286	Q12802
SPNVSLMQRMSDMLS	DCAF6	336	Q58WW2
LSERKQMALLMQMTA	ANKRD12	131	Q6UB98
SSLPGLSRMEQMSLM	DMXL1	1496	Q9Y485
SLMSKSNSMLQKPTA	AFF4	241	Q9UHB7
MSSRLMSMRSANGLL	GPHN	696	Q9NQX3
SSAVLMPMERQMSVN	CREB5	191	Q02930
TLSNMLPVRLATAMM	PNPLA2	321	Q96AD5
RQMKLQRPMSMLTDV	MYO16	191	Q9Y6X6
SSMSMFNTTMGKLQR	GARIN4	16	Q8IYT1
IMQSSQSMSKLTLTP	ATRN	841	O75882
MLKTMMSVSRNELLQ	C1D	31	Q13901
LSSITMPKMASLFLM	OR51D1	86	Q8NGF3
SPLLIMMLKMIFNQT	PTGER3	296	P43115
SLSNRRTLMIMAQMG	IFNA5	31	P01569
KLQLLMRMISRMSQN	DEPDC1	616	Q5TB30
PNMAVMIKSLTRSTM	HROB	496	Q8N3J3
LRKSMIPSFMTMDQS	TUBGCP3	466	Q96CW5
LPMMISSMLQASVST	ABCC2	596	Q92887
ISFSSVTVPKMLMNM	OR1J1	71	Q8NGS3
SLMMGLKMLRPNTAT	MANEA	21	Q5SRI9
RPDTNLMRSMPSLMT	RIMS2	1111	Q9UQ26
KMSNMGTLNSSMLHR	PRICKLE1	576	Q96MT3
MIQSQRPMMLQSALA	DYNC2H1	631	Q8NCM8
QRIQSLMTKMTAMAN	CCDC93	251	Q567U6
MLLRSMFVTPNTMAS	HTT	1651	P42858
MATALMPKQATVMRQ	HEATR5B	246	Q9P2D3
MVISAMKSSPETSML	C2CD3	331	Q4AC94
LAMIPILHMSKQQSM	MT-CYB	301	P00156
ILHMSKQQSMMFRPL	MT-CYB	306	P00156
LMSGEIIQMNSKMSL	DNAH3	1816	Q8TD57
STTPMLSLRQRMMHA	FNDC1	1291	Q4ZHG4
LSQNPLSIMMSRMSK	BCL9	1001	O00512
PRKHSVMMTFLSNML	COPG2	391	Q9UBF2
KTLSMIMQQGMASSS	MAMLD1	516	Q13495
KTLMQTLAQMMADSP	MBTPS2	96	O43462
LLPLMLMSMVSSSLN	CXCL17	11	Q6UXB2
KMTTTASEAMPTLLM	RTL9	631	Q8NET4
RAKTQLTSMLMMNLE	PMPCA	426	Q10713
ILMVASANIKTPMMS	POLR1A	1251	O95602
MSVLNSMLQSLMVLP	OR7A10	151	O76100
KMLATAPARGNMMST	FEZF1	11	A0PJY2
NMLMLLGVSNKMTDR	SEPHS1	121	P49903
RQLSMMLMLAQSNPQ	SELENOO	501	Q9BVL4
MPMSFQMQTQVLSRL	SETD1B	771	Q9UPS6
LQGMQLSRESPLMSM	STARD9	1321	Q9P2P6
MQPDMSLNVIKMKSS	RIPK1	1	Q13546
AGQKLMMSQRESLMS	PLAA	671	Q9Y263
QCKDMLMRLPQMTSS	TEX11	206	Q8IYF3
NRMSTMTPKIVMFTI	TMED2	96	Q15363
SMMMLGPQTLSIRNS	TOPAZ1	736	Q8N9V7
MQKTSLTLSLQRQMM	VPS9D1	176	Q9Y2B5
SMSNMNSSRMDSPKR	GRIN2A	906	Q12879