Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionactin binding

SPATA31A1 SPATA31A3 SPATA31A7 SPTB LRRK2 MACF1 PLEC ABLIM2 SPATA31A5

2.37e-05479659GO:0003779
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH17 DNAH9 DNAH11

2.59e-0518653GO:0008569
GeneOntologyMolecularFunctionglutamate receptor activity

GRIN1 GRM5 GRM8

9.11e-0527653GO:0008066
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH17 DNAH9 DNAH11

1.02e-0428653GO:0051959
GeneOntologyMolecularFunctioncytoskeletal protein binding

DIP2B SPATA31A1 SPATA31A3 SPATA31A7 SPTB LRRK2 MACF1 PLEC ABLIM2 USH2A SPATA31A5 FRMD5

1.95e-0410996512GO:0008092
GeneOntologyMolecularFunctionL-leucine binding

SESN3 SESN1

2.17e-047652GO:0070728
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH17 DNAH9 DNAH11

2.36e-0437653GO:0045505
GeneOntologyMolecularFunctionG protein-coupled glutamate receptor activity

GRM5 GRM8

3.70e-049652GO:0098988
GeneOntologyMolecularFunctionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity

GRM5 GRM8

3.70e-049652GO:0001640
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH17 DNAH9 DNAH11

1.54e-0370653GO:0003777
GeneOntologyMolecularFunctionSUMO binding

CASP8AP2 TOLLIP

1.72e-0319652GO:0032183
GeneOntologyMolecularFunctionamino acid binding

SESN3 GRIN1 SESN1

1.74e-0373653GO:0016597
GeneOntologyBiologicalProcessregulation of synaptic transmission, glutamatergic

RELN LRRK2 GRIN1 GRM5 GRM8

1.14e-0592665GO:0051966
GeneOntologyBiologicalProcesscell junction organization

RELN RHOD SPTB EGLN1 LRRK2 CNTNAP4 MACF1 NBEA FGFR1 GRIN1 PLEC GRM5

5.35e-059746612GO:0034330
GeneOntologyBiologicalProcesssynaptic transmission, glutamatergic

RELN LRRK2 GRIN1 GRM5 GRM8

6.50e-05132665GO:0035249
GeneOntologyBiologicalProcessforebrain cell migration

RELN LRRK2 FGFR1 EMX2

9.80e-0575664GO:0021885
GeneOntologyBiologicalProcessregulation of CAMKK-AMPK signaling cascade

EGLN1 LRRK2

1.00e-045662GO:1905289
GeneOntologyBiologicalProcesscerebral cortex development

RELN FGFR1 GRIN1 EMX1 EMX2

1.08e-04147665GO:0021987
GeneOntologyCellularComponentdendrite

DIP2B NELL2 RELN LRRK2 CNTNAP4 GRIN1 PLEC TXNRD2 FAS GRM5

2.97e-048586510GO:0030425
GeneOntologyCellularComponentdendritic tree

DIP2B NELL2 RELN LRRK2 CNTNAP4 GRIN1 PLEC TXNRD2 FAS GRM5

3.03e-048606510GO:0097447
GeneOntologyCellularComponentsomatodendritic compartment

DIP2B NELL2 RELN LRRK2 CNTNAP4 GRIN1 PLEC TXNRD2 FAS GRM5 GRM8 USH2A

3.56e-0412286512GO:0036477
GeneOntologyCellularComponentouter dynein arm

DNAH17 DNAH9

6.16e-0412652GO:0036157
GeneOntologyCellularComponentGATOR2 complex

SESN3 SESN1

6.16e-0412652GO:0061700
GeneOntologyCellularComponentdynein complex

DNAH17 DNAH9 DNAH11

6.36e-0454653GO:0030286
GeneOntologyCellularComponentneuronal cell body

DIP2B NELL2 RELN LRRK2 GRIN1 TXNRD2 FAS GRM8 USH2A

1.07e-03835659GO:0043025
GeneOntologyCellularComponentSeh1-associated complex

SESN3 SESN1

1.11e-0316652GO:0035859
MousePhenoincreased grooming behavior

LRRK2 CNTNAP4 NBEA GRIN1 FRMD5

7.04e-0674515MP:0001441
MousePhenoabsent incus lenticular process

FGFR1 EMX2

1.31e-052512MP:0030398
MousePhenoabnormal incus lenticular process morphology

FGFR1 EMX2

1.31e-052512MP:0030397
MousePhenoabnormal incus long process morphology

FGFR1 EMX2

3.91e-053512MP:0030396
MousePhenoabnormal stapes head morphology

FGFR1 EMX2

3.91e-053512MP:0030402
MousePhenoexcessive cerumen

FBXO11 FGFR1

3.91e-053512MP:0030419
MousePhenoabnormal excitatory postsynaptic current frequency

LRRK2 NBEA FRMD5

4.25e-0519513MP:0014377
MousePhenoincreased splenocyte number

TET2 FAS SESN1

8.77e-0524513MP:0009338
MousePhenoabnormal grooming behavior

LRRK2 CNTNAP4 NBEA GRIN1 FRMD5

1.37e-04137515MP:0001440
MousePhenoabnormal nervous system electrophysiology

LRRK2 FGFR1 GRIN1 PLEC EMX2 GRM5 FRMD5

1.78e-04329517MP:0002272
MousePhenoabnormal incudostapedial joint morphology

FGFR1 EMX2

1.94e-046512MP:0030108
MousePhenoincreased renal glomerulus apoptosis

LRRK2 FAS

2.71e-047512MP:0011369
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A5

8.26e-0612643PF15371
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A5

8.26e-0612643IPR027970
DomainAhpD-like

SESN3 SESN1

3.46e-053642IPR029032
DomainPA26

SESN3 SESN1

3.46e-053642PF04636
DomainSestrin

SESN3 SESN1

3.46e-053642IPR006730
Domain-

SESN3 SESN1

3.46e-0536421.20.1290.10
DomainActinin_actin-bd_CS

SPTB MACF1 PLEC

6.47e-0523643IPR001589
DomainACTININ_2

SPTB MACF1 PLEC

6.47e-0523643PS00020
DomainACTININ_1

SPTB MACF1 PLEC

6.47e-0523643PS00019
DomainSpectrin_repeat

SPTB MACF1 PLEC

1.32e-0429643IPR002017
Domain-

MACF1 PLEC

1.72e-0466423.90.1290.10
DomainSpectrin/alpha-actinin

SPTB MACF1 PLEC

1.77e-0432643IPR018159
DomainSPEC

SPTB MACF1 PLEC

1.77e-0432643SM00150
DomainPlectin_repeat

MACF1 PLEC

2.40e-047642IPR001101
DomainPlectin

MACF1 PLEC

2.40e-047642PF00681
DomainPLEC

MACF1 PLEC

2.40e-047642SM00250
DomainANF_lig-bd_rcpt

GRIN1 GRM5 GRM8

2.74e-0437643IPR001828
DomainANF_receptor

GRIN1 GRM5 GRM8

2.74e-0437643PF01094
Domain-

NELL2 CNTNAP4 NBEA USH2A

3.16e-04956442.60.120.200
DomainDHC_N1

DNAH9 DNAH11

3.19e-048642PF08385
DomainGPCR_3_mtglu_rcpt

GRM5 GRM8

3.19e-048642IPR000162
DomainDynein_heavy_dom-1

DNAH9 DNAH11

3.19e-048642IPR013594
DomainPeripla_BP_I

GRIN1 GRM5 GRM8

3.21e-0439643IPR028082
DomainLaminin_G_2

NELL2 CNTNAP4 USH2A

3.46e-0440643PF02210
DomainLamG

NELL2 CNTNAP4 USH2A

4.60e-0444643SM00282
DomainCUE

TOLLIP SMARCAD1

5.11e-0410642PS51140
DomainCUE

TOLLIP SMARCAD1

5.11e-0410642IPR003892
DomainNCD3G

GRM5 GRM8

8.80e-0413642PF07562
DomainGPCR_3_9-Cys_dom

GRM5 GRM8

8.80e-0413642IPR011500
DomainDynein_heavy_chain_D4_dom

DNAH9 DNAH11

1.02e-0314642IPR024317
DomainDynein_HC_stalk

DNAH9 DNAH11

1.02e-0314642IPR024743
DomainDynein_heavy_dom-2

DNAH9 DNAH11

1.02e-0314642IPR013602
DomainDHC_N2

DNAH9 DNAH11

1.02e-0314642PF08393
DomainMT

DNAH9 DNAH11

1.02e-0314642PF12777
DomainAAA_8

DNAH9 DNAH11

1.02e-0314642PF12780
DomainATPase_dyneun-rel_AAA

DNAH9 DNAH11

1.02e-0314642IPR011704
DomainGPCR_3_CS

GRM5 GRM8

1.02e-0314642IPR017979
DomainAAA_5

DNAH9 DNAH11

1.02e-0314642PF07728
DomainLaminin_G

NELL2 CNTNAP4 USH2A

1.04e-0358643IPR001791
DomainDHC_fam

DNAH9 DNAH11

1.18e-0315642IPR026983
DomainDynein_heavy_dom

DNAH9 DNAH11

1.18e-0315642IPR004273
DomainDynein_heavy

DNAH9 DNAH11

1.18e-0315642PF03028
DomainCH

SPTB MACF1 PLEC

1.44e-0365643SM00033
DomainCH

SPTB MACF1 PLEC

1.78e-0370643PF00307
Domain-

SPTB MACF1 PLEC

1.86e-03716431.10.418.10
DomainCH

SPTB MACF1 PLEC

2.01e-0373643PS50021
DomainCH-domain

SPTB MACF1 PLEC

2.17e-0375643IPR001715
DomainWD40

KCTD3 LRRK2 WSB2 NBEA EIPR1

2.24e-03268645SM00320
DomainGPCR_3

GRM5 GRM8

2.33e-0321642IPR000337
Domainzf-MYND

ZMYND10 EGLN1

2.33e-0321642PF01753
DomainWD40_repeat

KCTD3 LRRK2 WSB2 NBEA EIPR1

2.39e-03272645IPR001680
DomainZnf_MYND

ZMYND10 EGLN1

2.55e-0322642IPR002893
Domain7tm_3

GRM5 GRM8

2.55e-0322642PF00003
DomainG_PROTEIN_RECEP_F3_2

GRM5 GRM8

2.55e-0322642PS00980
DomainG_PROTEIN_RECEP_F3_3

GRM5 GRM8

2.55e-0322642PS00981
DomainG_PROTEIN_RECEP_F3_1

GRM5 GRM8

2.55e-0322642PS00979
DomainG_PROTEIN_RECEP_F3_4

GRM5 GRM8

2.55e-0322642PS50259
DomainZF_MYND_1

ZMYND10 EGLN1

2.55e-0322642PS01360
DomainGPCR_3_C

GRM5 GRM8

2.55e-0322642IPR017978
DomainZF_MYND_2

ZMYND10 EGLN1

2.55e-0322642PS50865
DomainSpectrin

SPTB MACF1

2.79e-0323642PF00435
DomainWD40_repeat_dom

KCTD3 LRRK2 WSB2 NBEA EIPR1

3.49e-03297645IPR017986
DomainAMP-binding

DIP2B ACSF3

4.73e-0330642PF00501
DomainAMP-dep_Synth/Lig

DIP2B ACSF3

4.73e-0330642IPR000873
Domain-

KCTD3 LRRK2 WSB2 NBEA EIPR1

5.64e-033336452.130.10.10
DomainWD40/YVTN_repeat-like_dom

KCTD3 LRRK2 WSB2 NBEA EIPR1

5.79e-03335645IPR015943
DomainConA-like_dom

NELL2 CNTNAP4 NBEA USH2A

6.75e-03219644IPR013320
Pubmed

The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5

1.88e-10667420850414
Pubmed

Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5

1.88e-10667425930072
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5

1.30e-072467432212159
Pubmed

The same enhancer regulates the earliest Emx2 expression in caudal forebrain primordium, subsequent expression in dorsal telencephalon and later expression in the cortical ventricular zone.

RELN EMX1 EMX2

1.36e-07667320667915
Pubmed

The lack of Emx2 causes impairment of Reelin signaling and defects of neuronal migration in the developing cerebral cortex.

RELN EMX1 EMX2

2.38e-07767310648716
Pubmed

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

DNAH17 DNAH9 DNAH11

2.38e-07767331178125
Pubmed

Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain.

RELN EMX1 EMX2

1.12e-06116739367432
Pubmed

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.

RELN GRIN1 GRM5 GRM8

1.77e-064567425979088
Pubmed

Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double mutant cerebral cortex.

RELN EMX1 EMX2

1.93e-061367312091317
Pubmed

Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding.

RELN EMX1 EMX2

1.93e-061367312561075
Pubmed

The transcription factors Emx1 and Emx2 suppress choroid plexus development and promote neuroepithelial cell fate.

EMX1 EMX2

3.66e-06267216793035
Pubmed

NMDA receptor-dependent pattern transfer from afferents to postsynaptic cells and dendritic differentiation in the barrel cortex.

GRIN1 EMX1

3.66e-06267212498788
Pubmed

Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2.

EMX1 EMX2

3.66e-06267234016958
Pubmed

Emx homeogenes and mouse brain development.

EMX1 EMX2

3.66e-06267210906797
Pubmed

Activation of NMDA receptors reduces metabotropic glutamate receptor-induced long-term depression in the nucleus accumbens via a CaMKII-dependent mechanism.

GRIN1 GRM5

3.66e-06267222947307
Pubmed

Exuberant thalamocortical axon arborization in cortex-specific NMDAR1 knockout mice.

GRIN1 EMX1

3.66e-06267215803506
Pubmed

Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex.

EMX1 EMX2

3.66e-0626721352754
Pubmed

The association analysis of RELN and GRM8 genes with autistic spectrum disorder in Chinese Han population.

RELN GRM8

3.66e-06267217955477
Pubmed

Lesion-induced thalamocortical axonal plasticity in the S1 cortex is independent of NMDA receptor function in excitatory cortical neurons.

GRIN1 EMX1

3.66e-06267212417641
Pubmed

Direct interaction enables cross-talk between ionotropic and group I metabotropic glutamate receptors.

GRIN1 GRM5

3.66e-06267218182392
Pubmed

Decreased pain response in mice following cortex-specific knockout of the N-methyl-D-aspartate NR1 subunit.

GRIN1 EMX1

3.66e-06267217822844
Pubmed

Evaluation of morphine analgesia and motor coordination in mice following cortex-specific knockout of the N-methyl-D-aspartate NR1-subunit.

GRIN1 EMX1

3.66e-06267218423864
Pubmed

Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis.

EGLN1 TXNRD2

3.66e-06267225647640
Pubmed

Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis.

EMX1 EMX2

3.66e-06267234364391
Pubmed

EMX homeobox genes regulate microphthalmia and alter melanocyte biology.

EMX1 EMX2

3.66e-06267216197942
Pubmed

Sestrins induce natural killer function in senescent-like CD8+ T cells.

SESN3 SESN1

3.66e-06267232231301
Pubmed

Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex.

GRIN1 EMX1

3.66e-06267210963597
Pubmed

Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain.

RELN EMX1 EMX2

3.76e-061667321925158
Pubmed

Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream.

RELN EMX1 EMX2

4.56e-061767323292680
Pubmed

A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex.

RELN EMX1 EMX2

4.56e-061767317694053
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

TET2 NELL2 RELN SPTB SESN3 TOLLIP MACF1 FBXO11 NBEA SMARCAD1 ZNF619 PLEC

5.63e-061285671235914814
Pubmed

Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice.

EMX1 GRM5

1.10e-05367226195764
Pubmed

Sestrin1, 2, and 3 are dispensable for female fertility in mice.

SESN3 SESN1

1.10e-05367238297375
Pubmed

Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice.

CR1 FAS

1.10e-05367211907125
Pubmed

Impaired postnatal development of hippocampal neurons and axon projections in the Emx2-/- mutants.

RELN EMX2

1.10e-05367212437591
Pubmed

Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice.

GRIN1 GRM5

1.10e-05367229062097
Pubmed

Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus.

TET2 FAS

1.10e-05367235499082
Pubmed

PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse.

SESN3 SESN1

1.10e-05367212607115
Pubmed

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map.

RELN EMX1

1.10e-05367232203496
Pubmed

Ezh2 is involved in radial neuronal migration through regulating Reelin expression in cerebral cortex.

RELN EMX1

1.10e-05367226499080
Pubmed

An amphioxus Emx homeobox gene reveals duplication during vertebrate evolution.

EMX1 EMX2

1.10e-05367211018158
Pubmed

Sestrins are evolutionarily conserved mediators of exercise benefits.

SESN3 SESN1

1.10e-05367231929512
Pubmed

mGluR5 in cortical excitatory neurons exerts both cell-autonomous and -nonautonomous influences on cortical somatosensory circuit formation.

EMX1 GRM5

1.10e-05367221159961
Pubmed

Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways.

NBEA GRIN1

1.10e-05367225934101
Pubmed

Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry.

EMX1 GRM5

1.10e-05367221976507
Pubmed

Essential role of presynaptic NMDA receptors in activity-dependent BDNF secretion and corticostriatal LTP.

GRIN1 EMX1

1.10e-05367225467984
Pubmed

Circulating Sestrin Levels Are Increased in Hypertension Patients.

SESN3 SESN1

1.10e-05367232626541
Pubmed

Interactions between microRNA-200 family and Sestrin proteins in endometrial cancer cell lines and their significance to anoikis.

SESN3 SESN1

1.10e-05367231073887
Pubmed

The functions and roles of sestrins in regulating human diseases.

SESN3 SESN1

1.10e-05367234979914
Pubmed

Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets.

RELN EMX1 EMX2

1.18e-052367320089898
Pubmed

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

GRIN1 GRM5 GRM8

1.34e-052467335746896
Pubmed

Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial pallium.

RELN EMX1 EMX2

1.34e-052467315858069
Pubmed

Patterning the dorsal telencephalon: a role for sonic hedgehog?

RELN EMX1 EMX2

1.52e-052567317959802
Pubmed

A crucial role for primary cilia in cortical morphogenesis.

RELN EMX1 EMX2

1.52e-052567319036983
Pubmed

FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development.

RELN FGFR1 EMX2

1.52e-052567318625063
Pubmed

Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.

RELN GRIN1 GRM5

1.52e-052567331665922
Pubmed

A novel role for Dbx1-derived Cajal-Retzius cells in early regionalization of the cerebral cortical neuroepithelium.

RELN EMX1 EMX2

2.16e-052867320668538
Pubmed

The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis.

CASP8AP2 FAS

2.19e-05467210235259
Pubmed

Emx and Otx homeobox genes in the developing mouse brain.

EMX1 EMX2

2.19e-0546727901323
Pubmed

Emx1 and Emx2 show different patterns of expression during proliferation and differentiation of the developing cerebral cortex in the mouse.

EMX1 EMX2

2.19e-0546728743751
Pubmed

Cholinergic Neurons of the Medial Septum Are Crucial for Sensorimotor Gating.

EMX1 GRM5

2.19e-05467231028115
Pubmed

Nested expression domains of four homeobox genes in developing rostral brain.

EMX1 EMX2

2.19e-0546721353865
Pubmed

Conserved homeobox genes in the developing brain.

EMX1 EMX2

2.19e-0546727915635
Pubmed

Expression of the Emx-1 and Dlx-1 homeobox genes define three molecularly distinct domains in the telencephalon of mouse, chick, turtle and frog embryos: implications for the evolution of telencephalic subdivisions in amniotes.

EMX1 EMX2

2.19e-0546729570774
Pubmed

The transcription factor Foxg1 regulates telencephalic progenitor proliferation cell autonomously, in part by controlling Pax6 expression levels.

EMX1 EMX2

2.19e-05467221418559
Pubmed

Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries.

DNAH9 DNAH11

2.19e-05467236140829
Pubmed

FGF22 signaling regulates synapse formation during post-injury remodeling of the spinal cord.

FGFR1 EMX1

2.19e-05467225766255
Pubmed

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.

SESN3 SESN1

2.19e-05467222958918
Pubmed

Massive loss of Cajal-Retzius cells does not disrupt neocortical layer order.

RELN EMX1

2.19e-05467216410414
Pubmed

Chromosome locations of human EMX and OTX genes.

EMX1 EMX2

2.19e-0546727959790
Pubmed

A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment.

FBXO11 EMX2

3.64e-05567220057387
Pubmed

Modified N-methyl-D-aspartate receptor subunit expression emerges in reeler Purkinje cells after accomplishment of the adult wild-type expression.

RELN GRIN1

3.64e-0556729004271
Pubmed

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.

TET2 EGLN1

3.64e-05567221251613
Pubmed

Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons.

EMX1 EMX2

3.64e-05567215247416
Pubmed

Choreography of early thalamocortical development.

RELN EMX2

3.64e-05567212764042
Pubmed

Reelin signaling facilitates maturation of CA1 glutamatergic synapses.

RELN GRIN1

3.64e-05567217229826
Pubmed

RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C.

RHOD FGFR1

3.64e-05567223034183
Pubmed

Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system.

EMX1 EMX2

3.64e-05567210601036
Pubmed

DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes.

DNAH9 DNAH11

3.64e-05567226909801
Pubmed

Sestrin2 is a leucine sensor for the mTORC1 pathway.

SESN3 SESN1

3.64e-05567226449471
Pubmed

The GDNF-GFRα1 complex promotes the development of hippocampal dendritic arbors and spines via NCAM.

GRIN1 EMX1

3.64e-05567227707798
Pubmed

TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation.

TET2 EGLN1

3.64e-05567232963106
Pubmed

Retinoic acid induces stage-specific antero-posterior transformation of rostral central nervous system.

EMX1 EMX2

5.46e-0566727669695
Pubmed

The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.

GRM5 GRM8

5.46e-05667211943148
Pubmed

Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice.

CR1 FAS

5.46e-05667223109726
Pubmed

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.

DNAH9 DNAH11

5.46e-05667233347437
Pubmed

NMDA receptors control development of somatosensory callosal axonal projections.

GRIN1 EMX1

5.46e-05667233661095
Pubmed

Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neurons.

RELN EMX2

5.46e-05667215376319
Pubmed

Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain.

EMX1 EMX2

5.46e-05667211782416
Pubmed

Layer I Interneurons Sharpen Sensory Maps during Neonatal Development.

GRIN1 EMX1

5.46e-05667229937280
Pubmed

Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons.

RELN EMX1 EMX2

6.42e-054067326671461
Pubmed

A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype.

RELN EMX2

7.63e-05767221214893
Pubmed

Specific contribution of neurons from the Dbx1 lineage to the piriform cortex.

RELN EMX1

7.63e-05767233863910
Pubmed

CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.

DNAH17 DNAH11

7.63e-05767233139725
Pubmed

Patterns of gene expression in the neural plate and neural tube subdivide the embryonic forebrain into transverse and longitudinal domains.

EMX1 EMX2

7.63e-0576729078438
Pubmed

Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres.

EMX1 EMX2

7.63e-0576727605629
Pubmed

Increase in reelin-positive cells in the marginal zone of Pax6 mutant mouse cortex.

RELN EMX2

7.63e-05767212764029
Pubmed

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.

SESN3 SESN1

7.63e-05767225259925
Pubmed

Emx1 and Emx2 functions in development of dorsal telencephalon.

EMX1 EMX2

7.63e-0576729006071
Pubmed

NMDA-receptor proteins are upregulated in the hippocampus of postnatal heterozygous reeler mice.

RELN GRIN1

7.63e-05767216438943
CytobandEnsembl 112 genes in cytogenetic band chr9q12

SPATA31A7 SPATA31A5

5.84e-058672chr9q12
Cytoband9p13.1

SPATA31A1 SPATA31A3

5.67e-04246729p13.1
Cytoband11q14.3

RHOD GRM5

1.01e-033267211q14.3
Cytoband12q12

NELL2 LRRK2

2.17e-034767212q12
GeneFamilyDyneins, axonemal

DNAH17 DNAH9 DNAH11

6.68e-0617403536
GeneFamilyEF-hand domain containing|Plakins

MACF1 PLEC

1.33e-048402939
GeneFamilyGlutamate metabotropic receptors|Protein phosphatase 1 regulatory subunits

GRM5 GRM8

1.33e-048402281
GeneFamilyZinc fingers MYND-type

ZMYND10 EGLN1

9.76e-042140287
CoexpressionMARZEC_IL2_SIGNALING_DN

PIK3R3 SESN3 FAS SESN1

1.91e-0636654M13276
CoexpressionTRAVAGLINI_LUNG_CLASSICAL_MONOCYTE_CELL

TET2 RNASE6 LRRK2 NADK PLEC CR1 GNS

4.76e-06270657M41699
CoexpressionGAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_UP

DPY19L1 FAS SESN1

3.63e-0526653M14024
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

RELN CNTNAP4 GRM5 USH2A DNAH9 FRMD5

8.15e-08146666c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

NELL2 RELN CNTNAP4 GRM8 USH2A DNAH9

1.56e-0716366619c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|COVID-19 / Disease (COVID-19 only), tissue and cell type

RELN CNTNAP4 GRM5 GRM8 USH2A

2.92e-061506650205318a870e091add66ee4305747dda9f51510d
ToppCell15-Airway-Epithelial-Multiciliated_precursor|Airway / Age, Tissue, Lineage and Cell class

ZMYND10 DNAH17 ABLIM2 DNAH9 DNAH11

6.73e-06178665d8e0a696bdd6af6422d72af0413f9dbd6bc02afa
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN CNTNAP4 USH2A DNAH9 DNAH11

7.91e-061846652cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN CNTNAP4 USH2A DNAH9 DNAH11

7.91e-06184665ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN CNTNAP4 USH2A DNAH9 DNAH11

7.91e-061846652b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 FGFR1 ACMSD DNAH11 PDZD2

8.34e-06186665f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN PIK3R3 CNTNAP4 GRM8 PREX2

9.48e-06191665fa50a3c7ff86e1ee07100da1ace0b0fa1b0ab26b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF613 EMX1 EMX2 PP2D1

4.84e-0513566452b5c664c0b7a303c6084d508748dcb6c38a0c23
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

RELN CNTNAP4 GRM5 USH2A

6.91e-05148664d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZMYND10 USH2A DNAH9 DNAH11

8.07e-051546649ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZMYND10 USH2A DNAH9 DNAH11

8.07e-0515466458072ce422d09f2de602580325eaac6c4ec6c136
ToppCelldroplet-Thymus-nan-18m-Myeloid-B_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNASE6 SESN1 GNS PREX2

8.69e-05157664a9e077f686382303f0437ebfa4f11d273ba9fe40
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

RELN GRM5 USH2A DNAH9

9.13e-051596645335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellP07-Endothelial-lymphatic_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RELN GRAMD1A DHRS2 ABLIM2

1.00e-041636645cbab3d03bb1af9391ecad635d6eea1dd42c1337
ToppCellP07-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RELN GRAMD1A DHRS2 ABLIM2

1.00e-04163664322ba94c3ec1e1859c2e2195ecb3f7dab8d190f6
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 FGFR1 ACMSD PDZD2

1.03e-041646641cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCellfacs-Marrow-B-cells-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN SPTB ACMSD ABLIM2

1.05e-04165664361a605d8f833d9ec54b120480dce397da35f9c3
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP8AP2 DPY19L1 MACF1 FRMD5

1.15e-0416966416c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NBEA GRM5 DNAH9 DNAH11

1.15e-0416966414aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH17 LRRK2 PREX2 DNAH11

1.18e-041706645d5f208682be21ed58320f5fc083a7898f8712da
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DNAH17 LRRK2 GRM5 DNAH11

1.35e-04176664327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZMYND10 ALPK1 DNAH9 DNAH11

1.38e-04177664e8bb4f8ecd5e283efec966b9fc2040a6152d5551
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DNAH17 CNTNAP4 NBEA FGFR1

1.38e-04177664bd602db857f37869ef76d14c05ef522c509f08ee
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DPY19L1 FGFR1 DSEL GRM8

1.38e-0417766457033ee0d49a4a50fc25328a4a44d4de2b35f505
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L1 PLEC GRM5 GRM8

1.41e-04178664a0ab20c588e7d43d0320d4779d9ab95c1c86e297
ToppCelldroplet-Spleen-SPLEEN-1m-Lymphocytic-plasma_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN NBEA ABLIM2 FRMD5

1.41e-04178664b902059c3f861108fc64cbdc05e6f44378f5be2c
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_3|356C / Donor, Lineage, Cell class and subclass (all cells)

ZNF599 SESN3 ABLIM2 FAS

1.44e-04179664f378307eb20f002450c748b7be2289d6db2fcbcb
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NELL2 DPY19L1 EMX1 GRM8

1.50e-0418166458f76bb9ea1518c2b629a0256a3f6595a9278152
ToppCelldroplet-Liver-nan-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPY19L1 PIK3R3 EGLN1 PREX2

1.50e-04181664fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

ZMYND10 GRM5 DNAH9 DNAH11

1.54e-041826647ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FGFR1 PREX2 DNAH11 PDZD2

1.54e-04182664a05e5978ef5f7fac7eeb2ba1c0103ea90d5e9136
ToppCell21-Trachea-Epithelial-Multiciliated_precursor|Trachea / Age, Tissue, Lineage and Cell class

ZMYND10 DPY19L1 ABLIM2 DNAH9

1.54e-041826646e35892fa959ee31591850ded8f1088195ddeb01
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FGFR1 PREX2 DNAH11 PDZD2

1.54e-04182664831b5ce46b41efe01c4db6016c2f43148611373d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TET2 SPTB ABLIM2 CR1

1.57e-04183664eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NELL2 ZMYND10 DNAH9 DNAH11

1.57e-0418366458847e8f3a7ce3e33adba9477bcd55e769a64a90
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-B_cells-FCRL4+_Memory_B|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE6 LRRK2 SESN3 CR1

1.60e-0418466495cf125127658c4c04445c61809d1aed21ee1f83
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ZMYND10 GRM5 DNAH9 DNAH11

1.60e-041846645daff849625f2f41d56615569c0ed59cd733b34c
ToppCell15-Trachea-Epithelial-Multiciliated_precursor|Trachea / Age, Tissue, Lineage and Cell class

ZMYND10 DPY19L1 SNAPC1 ABLIM2

1.63e-041856649a8b8360d99375b726ca8e3c9a3f9b08919892d7
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

ZMYND10 GRM5 DNAH9 DNAH11

1.63e-0418566430f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellPCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_ErythroMeg|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RELN SPTB CR1 EMX2

1.67e-041866643b60a153e6cfc1b977a1f8b8f3bcaf75d1f4ff5b
ToppCellPCW_07-8.5-Hematologic_ErythroMegGranulo|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RELN SPTB CR1 EMX2

1.67e-04186664294839944266407c40ef86e1d3e0fce4652b70ff
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRRK2 CNTNAP4 PLEC USH2A

1.67e-0418666423b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN CNTNAP4 GRM8 PREX2

1.67e-04186664310d16f4e5cffee3ea6d7635508c513a3b92131e
ToppCellPCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_ErythroMeg-erythro|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RELN SPTB CR1 EMX2

1.67e-041866646078aa16261554c7fd41137b8de1362d15b30490
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RHOD KCTD3 GRIN1 FRMD5

1.67e-04186664827f2f2ddde315d1e5970dd56f906c555ec699af
ToppCellCiliated_cells-B-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

NELL2 ZMYND10 DNAH9 DNAH11

1.70e-041876642b4262c2e7c7830a976be168cee6eeb738d4feda
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZNF599 SESN3 ABLIM2 FAS

1.70e-04187664c8278525b3e1d3f3f4defcaf109cce22dd2e157a
ToppCellCiliated_cells-B-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

NELL2 ZMYND10 NBEA DNAH9

1.70e-041876646fa38dbccca36bc7a4fef46de74c6688f599f421
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 FGFR1 ACMSD PDZD2

1.70e-04187664c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell390C-Epithelial_cells-Epithelial-F_(Ciliated)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NELL2 ZMYND10 DNAH9 DNAH11

1.70e-0418766488f785932e67c613db0dda84496de351359ed962
ToppCell390C-Epithelial_cells-Epithelial-F_(Ciliated)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NELL2 ZMYND10 DNAH9 DNAH11

1.70e-041876648896a00b30d11b90ca42726d4e122174a30b161b
ToppCellPCW_05-06-Hematologic_ErythroMegGranulo-Hem_ErythroMeg|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

RELN SPTB CR1 EMX2

1.74e-041886645d6faf45a9c0794b0c30b0a0601c10afbb8aa9ed
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN CNTNAP4 GRM8 PREX2

1.74e-041886640501a8aa850bd2e347020abd1cac4d8075738189
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN CNTNAP4 GRM8 PREX2

1.74e-04188664433a25fe52914e07e7ba695881f9bcca2d9467ff
ToppCellPCW_05-06-Hematologic_ErythroMegGranulo|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

RELN SPTB CR1 EMX2

1.74e-04188664a0873783f0a2cd852563c05a275dddc72905ced2
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NELL2 ZMYND10 DNAH9 DNAH11

1.74e-0418866482c006f43c93f4a867953a446864f02b44536a23
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 FGFR1 ACMSD PDZD2

1.74e-04188664af740fa78542438fdff627ea1f74f4eee43316be
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NELL2 ZMYND10 DNAH9 DNAH11

1.74e-04188664da59b5c0a4b11690a39a964c1a0a83e66aa0972b
ToppCellPCW_05-06-Hematologic_ErythroMegGranulo-Hem_ErythroMeg-erythro|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

RELN SPTB CR1 EMX2

1.74e-0418866429d804232d974a8c0029300345b287005b09bade
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

ZMYND10 GRM5 DNAH9 DNAH11

1.74e-041886642b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCellkidney_cells-Hypertensive_with+without-CKD|kidney_cells / Celltypes from Cells and Nuclei per compartment and clinical group

PHKG1 LRRK2 SESN3 EMX2

1.74e-0418866490188b60ff893754f7938fe8edab79758827168e
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ZMYND10 GRM5 DNAH9 DNAH11

1.77e-0418966468a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN CNTNAP4 GRM8 PREX2

1.77e-04189664f0aaf2994d319a39877d2845eaab9f166adead4e
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

NELL2 ZMYND10 DNAH9 DNAH11

1.81e-04190664a90a38fccdbf75a286b4d258fc54920c02b282f7
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-B_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNASE6 LRRK2 MACF1 SESN1

1.81e-04190664ee7b60cdf93c695ea2d59a170ca8cf4dc93e7eb2
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN CNTNAP4 GRM8 PREX2

1.85e-041916647b386512284dfaa0e95358b28ee82632ee965e64
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PIK3R3 CNTNAP4 GRM8 PREX2

1.85e-041916644b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCellControl-CD8+_T_naive|Control / Disease condition and Cell class

NELL2 GRAMD1A NBEA DSEL

1.92e-04193664627d345baf1940218c61907305705298e473dbab
ToppCellsevere-CD4+_Tcm|World / disease stage, cell group and cell class

NELL2 SESN3 DSEL SESN1

1.92e-04193664be0370b2f0093ad0b9d876297bd196d0160f3d99
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ZMYND10 DSEL DNAH9 DNAH11

1.92e-04193664c3522693439c23830d8a3f20854539ccb7a666e0
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN PIK3R3 CNTNAP4 PREX2

1.96e-0419466452aebb0b563e2c2058e7f0554ae870e47692b163
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN PIK3R3 CNTNAP4 PREX2

1.96e-04194664bd06e2b8d8c06cddf2e4f58849b86e09013acae1
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RELN DHRS2 ABLIM2 CR1

1.96e-0419466443eb677a76634bb9a48a40e0d607c4936ae64bcc
ToppCellCOVID_vent-Myeloid-Monocytic-Neutrophil|COVID_vent / Disease condition, Lineage, Cell class and subclass

LRRK2 NADK ALPK1 CR1

1.96e-04194664eb23b171e429165dd26a64377eae7fa2ce25f547
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZMYND10 NBEA DNAH9 DNAH11

2.00e-04195664649fd2336e963f6a150d182a53ad5dd838ca80b1
ToppCellPND01-Mesenchymal-Mesenchymal_structural|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MACF1 FGFR1 SESN1 PREX2

2.00e-041956646bb6349d6ec8da094fe1c7c590021989337aeb0b
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN MACF1 NBEA GNS

2.00e-041956643e519cffa6144a62b06124642a14c9ff39b76554
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZMYND10 NBEA DNAH9 DNAH11

2.00e-04195664129ad5f4253ecb1a8477cc38773e6e91ea9570b0
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZMYND10 NBEA DNAH9 DNAH11

2.00e-041956643e70ee987d66d450062d5df3d7c733ccc7344470
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZMYND10 NBEA DNAH9 DNAH11

2.00e-041956649651ee03738226ee10e901f8b9ec6a417eb9c301
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MACF1 FGFR1 SESN1 PREX2

2.00e-04195664a3b468125e48f072255cede7645f6692298ecf54
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN MACF1 NBEA GNS

2.00e-041956647796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRRK2 NADK ALPK1 CR1

2.04e-04196664fe8d3f45a64323947c36b127355d5940eb56c0ca
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRRK2 NADK ALPK1 CR1

2.04e-04196664526d037bb12d81f1c235c60ddc787fbad0bbad77
ToppCellmedial-2-Hematologic-Classical_Monocyte|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TET2 RNASE6 LRRK2 CR1

2.08e-04197664fbff79d6ece1605126ae0caa0c71253ea557779c
ToppCellmedial-Hematologic-Classical_Monocyte|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TET2 RNASE6 LRRK2 CR1

2.08e-041976643960eac4b6753e3294e13901f6ea13d894275c8d
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area|World / Primary Cells by Cluster

NELL2 NBEA GRM5 PDZD2

2.08e-0419766479b9e7f2e8e33b3c547f716be5667156c48b0dfc
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area-33|World / Primary Cells by Cluster

NELL2 NBEA GRM5 PDZD2

2.08e-04197664d20f29088e9afd8a960d6f680075c380e550f8a7
ToppCellmedial-Hematologic-Classical_Monocyte-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TET2 RNASE6 LRRK2 CR1

2.08e-04197664ae2b51d4e91126ee0a0f69c040297c2a78ce27dd
ToppCellcontrol-Myeloid-Non-resident_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TET2 LRRK2 NADK CR1

2.08e-04197664df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZMYND10 NBEA DNAH9 DNAH11

2.08e-04197664d83c61d2b5742e463122e1a98c7197a5b5b3d41b
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RNASE6 LRRK2 CR1 GNS

2.12e-04198664cf0fda1a24449cfd8ed56ffc7841d8accb187949
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

DPY19L1 ALPK1 EMX1 EMX2

2.12e-041986646d12ecaa9532c134d9c4562534dcb59a6420b4d3
ToppCellsevere-HLA-DR+_CD83+_Monocyte|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TET2 RNASE6 LRRK2 GNS

2.12e-04198664a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RNASE6 LRRK2 CR1 GNS

2.12e-041986647e1f08dae11a7cc7949a5622d82c7e6660d06dea
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like-IPs_and_early_cortical_neurons|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

DPY19L1 ALPK1 EMX1 EMX2

2.12e-041986647943e4f67c3d6efb5c8b00aa0ff3cfe7be10c48d
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RNASE6 LRRK2 CR1 GNS

2.12e-04198664525adc91fd8f2ad957b1879a5bf3950baa7d5ef8
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RNASE6 LRRK2 CR1 GNS

2.12e-0419866470e62d815b2a0aa5327ff94d6f4d503176e007b9
Diseasesensorineural hearing loss (implicated_via_orthology)

ZMYND10 DNAH17 DNAH9

8.36e-0619623DOID:10003 (implicated_via_orthology)
DiseaseMalaria, Falciparum

CR1 FAS

2.60e-054622C0024535
DiseasePrimary Ciliary Dyskinesia

ZMYND10 DNAH9 DNAH11

1.34e-0447623C4551720
Diseasemelanoma

TET2 CNTNAP4 ACSF3 GRM5

1.46e-04126624EFO_0000756
Diseaseretinal detachment (biomarker_via_orthology)

FGFR1 FAS

1.55e-049622DOID:5327 (biomarker_via_orthology)
Diseaseesophagus adenocarcinoma (is_marker_for)

EMX2 FAS

2.83e-0412622DOID:4914 (is_marker_for)
Diseaseschizophrenia (implicated_via_orthology)

RELN GRIN1 GRM5

4.02e-0468623DOID:5419 (implicated_via_orthology)
Diseasecortical thickness

DIP2B NELL2 RELN KCTD3 MACF1 SMARCAD1 FGFR1 PLEC PDZD2

5.03e-041113629EFO_0004840
Diseasebehavioural disinhibition measurement

EIPR1 DNAH9 DNAH11

5.36e-0475623EFO_0006946
Diseaseunipolar depression, response to selective serotonin reuptake inhibitor, mood disorder

DSEL GRM8

5.79e-0417622EFO_0003761, EFO_0004247, EFO_0005658
DiseasePR interval

MACF1 FBXO11 FGFR1 PLEC GRM8 DNAH11

6.01e-04495626EFO_0004462
Diseaseacute myeloid leukemia (is_implicated_in)

TET2 FGFR1 FAS

7.46e-0484623DOID:9119 (is_implicated_in)
Diseasehepatitis B (is_marker_for)

FAS PREX2

8.89e-0421622DOID:2043 (is_marker_for)
DiseaseAttention Deficit Disorder

GRM5 GRM8

9.77e-0422622C0041671
DiseaseMinimal Brain Dysfunction

GRM5 GRM8

9.77e-0422622C1321905
Diseaseotitis media (implicated_via_orthology)

FBXO11 FGFR1

9.77e-0422622DOID:10754 (implicated_via_orthology)
Diseasesunburn

ACSF3 FGFR1 GRM5

1.10e-0396623EFO_0003958
DiseaseAttention deficit hyperactivity disorder

GRM5 GRM8

1.16e-0324622C1263846
Diseasesciatic neuropathy (biomarker_via_orthology)

FGFR1 GRIN1 FAS

1.20e-0399623DOID:11446 (biomarker_via_orthology)
Diseasecorpus callosum central volume measurement

PLEC PDZD2

1.59e-0328622EFO_0010296
DiseaseToxic Encephalitis

RNASE6 EGLN1

1.70e-0329622C0154659
DiseaseNeurotoxicity Syndromes

RNASE6 EGLN1

1.70e-0329622C0235032
DiseaseEncephalopathy, Toxic

RNASE6 EGLN1

1.70e-0329622C0149504
DiseaseEpileptic encephalopathy

KCTD3 GRIN1

1.82e-0330622C0543888
DiseaseOvarian Mucinous Adenocarcinoma

LRRK2 ALPK1

1.94e-0331622C1335167

Protein segments in the cluster

PeptideGeneStartEntry
HWHSVLIQRLGKQVN

CNTNAP4

271

Q9C0A0
KGGHWVILQNVHLVA

DNAH11

3981

Q96DT5
WVQLQHHSKGEAKLL

ACMSD

26

Q8TDX5
KNGQALVALDKHWHL

ABLIM2

161

Q6H8Q1
HQNIRAVVTGLVHKW

ACSF3

216

Q4G176
THVRIHQTNNKWNKR

CASP8AP2

986

Q9UKL3
KQFHSVEVHKWRQIL

GRAMD1A

671

Q96CP6
KKKGRQRNAFWVHHL

ALPK1

1041

Q96QP1
GQHLWQRLSIHINKK

GRM5

926

P41594
IHDGKVKHNGQIWVL

NELL2

641

Q99435
LHGVDHWISKQGQKL

KIAA2026

171

Q5HYC2
LAQCLHWNVRKKQAH

NADK

421

O95544
WFKEINKHNQGTHLR

PDZD2

1801

O15018
WGVLAKQQTHVRKHQ

DPY19L1

431

Q2PZI1
WVQRVHAHKAKVALV

DIP2B

596

Q9P265
WENLGEKIAHRQHKL

MACF1

2331

O94854
WQHHSIKRVHKVKAN

LRP5L

181

A4QPB2
ALTWHRKNKHVQEAA

LRRK2

356

Q5S007
KVIGHWTNQLHLKVE

GRM8

486

O00222
NKNVLLHQAGEIWHI

EIPR1

56

Q53HC9
KHLWENLGEKIAHRQ

MACF1

6201

Q9UPN3
RQKNHQGHNRNVWAV

RELN

541

P78509
RKIRDQHLVWLNHKG

PIK3R3

306

Q92569
QHLVWLNHKGVRQKR

PIK3R3

311

Q92569
VNLQVKGKPVHLHIW

RHOD

56

O00212
VLQGNKRVHFIKWNE

FRMD5

231

Q7Z6J6
LSWIILKHRKGNNAH

CR1

1991

P17927
AEKGHWVILQNIHLV

DNAH17

3926

Q9UFH2
IWVKNHGNPIIRRNH

FBXO11

436

Q86XK2
HIQWLKHIEVNGSKI

FGFR1

286

P11362
HQRQDWKKHKLVCQG

EGLN1

46

Q9GZT9
NKNFNIHGTNKHWLI

GNS

256

P15586
IHGTNKHWLIRQAKT

GNS

261

P15586
AAHGQWELQRVHAKQ

CCDC177

361

Q9NQR7
QKKKGSHHINRWRIA

EMX1

261

Q04741
SQQKKKGTHHINRWR

EMX2

221

Q04743
KKGHWVILQNIHLVA

DNAH9

3951

Q9NYC9
SLWKNFKEHHQLQRI

DHRS2

231

Q13268
SKVRSWGKQLLHNHQ

DSEL

211

Q8IZU8
KVLIVAGHHNWIVAA

KCTD3

186

Q9Y597
GHWVKKGQQQNRAAL

PHKG1

356

Q16816
KWHEIIAIRHQAFGQ

USH2A

1606

O75445
ENHGIAWQARKELHK

SERAC1

86

Q96JX3
WRQFKHSEKVHVNLL

SESN1

456

Q9Y6P5
QKVGLNWLALVHKHG

SMARCAD1

501

Q9H4L7
QKILNILTNKHGAWG

NBEA

2041

Q8NFP9
RRQLEQHIKKWIIQH

SPATA31A7

596

Q8IWB4
KRLTKAHWFEIQHIQ

RNASE6

26

Q93091
WHFIGHLQKQNVNKL

PLPBP

91

O94903
IKNIVLEHQQWHKDR

SNAPC1

216

Q16533
RRQLEQHIKKWIIQH

SPATA31A3

596

Q5VYP0
KWALVRHQQIHAGVK

ZNF599

211

Q96NL3
RRQLEQHIKKWIIQH

SPATA31A1

596

Q5TZJ5
RRQLEQHIKKWIIQH

SPATA31A5

596

Q5VU36
QLLRNWHQLHGKKEA

FAS

276

P25445
WRQFKHSEKVHVNLL

SESN3

456

P58005
AHNGAKNPRWNKVIH

TOLLIP

91

Q9H0E2
LNWELNQHKKIHTGE

ZNF840P

456

A6NDX5
GHIVVNGWKIHNTAK

PREX2

321

Q70Z35
RNLHNKWLKHQAFVA

SPTB

1306

P11277
TKWVNKHLIKAQRHI

PLEC

186

Q15149
AVQNHVKSLNWGHRV

TXNRD2

131

Q9NNW7
WKSQLNAHQKIHTGE

ZNF613

271

Q6PF04
WQTHVLGKQHREKVA

ZNF830

66

Q96NB3
RGKWQAIAKHQLQHV

ZMYND10

346

O75800
HGKQIQVLSGHLQWV

WSB2

186

Q9NYS7
TQKHAALRWHLLQKQ

TET2

946

Q6N021
IQHQKWHTRKKLING

ZNF619

456

Q8N2I2
RFGQKSAVAKHQWVH

ZNF764

351

Q96H86
HKKQHVALATLGFQW

PP2D1

81

A8MPX8
VNQANKRHGSWKIQL

GRIN1

46

Q05586