Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	nuclear protein-containing complex	NFYC NCOA1 RANBP2 BICRAL SS18L1 AMOTL1 NUP54	5.09e-04	1377	23	7	GO:0140513
Pathway	REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP	NFYC NCOA1 SP1	2.31e-05	42	19	3	M27172
Pathway	BIOCARTA_TERC_PATHWAY	NFYC SP1	2.57e-05	6	19	2	MM1564
Pathway	BIOCARTA_TERC_PATHWAY	NFYC SP1	2.57e-05	6	19	2	M22047
Pathway	REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF	NFYC NCOA1 SP1	5.21e-05	55	19	3	M27001
Pathway	PID_ERB_GENOMIC_PATHWAY	NCOA1 DDX54	1.79e-04	15	19	2	M119
Pathway	WP_PRADERWILLI_AND_ANGELMAN_SYNDROME	CDKN2C RANBP2 NUP54	3.98e-04	109	19	3	M39542
Pathway	REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA	NFYC NCOA1 SP1	5.02e-04	118	19	3	M27316
Pathway	REACTOME_CELLULAR_RESPONSES_TO_STIMULI	NFYC CDKN2C NCOA1 SP1 RANBP2 NUP54	5.65e-04	828	19	6	M27827
Pathway	KEGG_MEDICUS_REFERENCE_NUCLEAR_EXPORT_OF_MRNA	RANBP2 NUP54	7.32e-04	30	19	2	M47752
Pathway	WP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY	NCOA1 SP1	7.82e-04	31	19	2	M39476
Pathway	REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN	RANBP2 NUP54	8.33e-04	32	19	2	M29579
Pathway	REACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS	RANBP2 NUP54	8.86e-04	33	19	2	M27016
Pathway	REACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN	RANBP2 NUP54	9.41e-04	34	19	2	M27041
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	RANBP2 NUP54	9.97e-04	35	19	2	M27320
Pathway	REACTOME_ONCOGENE_INDUCED_SENESCENCE	CDKN2C SP1	9.97e-04	35	19	2	M27190
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	RANBP2 NUP54	1.06e-03	36	19	2	M27245
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	RANBP2 NUP54	1.06e-03	36	19	2	M26974
Pathway	REACTOME_METABOLISM_OF_STEROIDS	NFYC NCOA1 SP1	1.09e-03	154	19	3	M27832
Pathway	REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS	RANBP2 NUP54	1.11e-03	37	19	2	M1029
Pathway	REACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS	RANBP2 NUP54	1.11e-03	37	19	2	M27038
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	RANBP2 NUP54	1.24e-03	39	19	2	M27238
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	RANBP2 NUP54	1.30e-03	40	19	2	MM14945
Pathway	REACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS	RANBP2 NUP54	1.37e-03	41	19	2	M29574
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS	RANBP2 NUP54	1.37e-03	41	19	2	MM15200
Pathway	REACTOME_SUMOYLATION	NCOA1 RANBP2 NUP54	1.42e-03	169	19	3	MM14919
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	RANBP2 NUP54	1.43e-03	42	19	2	MM15039
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	RANBP2 NUP54	1.50e-03	43	19	2	MM14609
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	RANBP2 NUP54	1.50e-03	43	19	2	M26975
Pathway	REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS	RANBP2 NUP54	1.57e-03	44	19	2	M109
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	RANBP2 NUP54	1.72e-03	46	19	2	M27397
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	RANBP2 NUP54	1.79e-03	47	19	2	MM14939
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	RANBP2 NUP54	1.79e-03	47	19	2	M27395
Pathway	REACTOME_GENE_SILENCING_BY_RNA	RANBP2 NUP54	1.95e-03	49	19	2	MM14837
Pathway	REACTOME_SUMOYLATION	NCOA1 RANBP2 NUP54	1.96e-03	189	19	3	M27214
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	RANBP2 NUP54	2.03e-03	50	19	2	MM14610
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	RANBP2 NUP54	2.11e-03	51	19	2	MM15151
Pathway	BIOCARTA_PPARA_PATHWAY	NCOA1 SP1	2.19e-03	52	19	2	M2404
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	RANBP2 NUP54	2.28e-03	53	19	2	M27212
Pathway	REACTOME_SNRNP_ASSEMBLY	RANBP2 NUP54	2.36e-03	54	19	2	M29594
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	RANBP2 NUP54	2.45e-03	55	19	2	MM14917
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	RANBP2 NUP54	2.72e-03	58	19	2	MM15149
Pathway	REACTOME_SNRNP_ASSEMBLY	RANBP2 NUP54	2.72e-03	58	19	2	MM14736
Pathway	REACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS	RANBP2 NUP54	2.81e-03	59	19	2	M27606
Pathway	PID_MYC_REPRESS_PATHWAY	NFYC SP1	3.20e-03	63	19	2	M254
Pathway	REACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION	NCOA1 SP1	3.20e-03	63	19	2	MM15613
Pathway	PID_ERA_GENOMIC_PATHWAY	NCOA1 DDX54	3.30e-03	64	19	2	M200
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	RANBP2 NUP54	3.40e-03	65	19	2	MM15147
Pathway	PID_HIF1_TFPATHWAY	NCOA1 SP1	3.51e-03	66	19	2	M255
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	RANBP2 NUP54	4.05e-03	71	19	2	M27394
Pathway	REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE	RANBP2 NUP54	4.27e-03	73	19	2	MM14948
Pathway	PID_E2F_PATHWAY	CDKN2C SP1	4.27e-03	73	19	2	M40
Pathway	REACTOME_ISG15_ANTIVIRAL_MECHANISM	RANBP2 NUP54	4.39e-03	74	19	2	M48006
Pathway	WP_LEPTIN_SIGNALING	NCOA1 SP1	4.62e-03	76	19	2	M39491
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	RANBP2 NUP54	4.74e-03	77	19	2	M27226
Pathway	REACTOME_GLUCOSE_METABOLISM	RANBP2 NUP54	5.36e-03	82	19	2	MM15394
Pathway	REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE	RANBP2 NUP54	5.36e-03	82	19	2	M27250
Pathway	PID_SMAD2_3NUCLEAR_PATHWAY	NCOA1 SP1	5.36e-03	82	19	2	M2
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	RANBP2 HS6ST2 NUP54	5.42e-03	271	19	3	MM15406
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	RANBP2 NUP54	5.62e-03	84	19	2	MM14929
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	RANBP2 NUP54	5.62e-03	84	19	2	M725
Pathway	REACTOME_GLUCOSE_METABOLISM	RANBP2 NUP54	5.75e-03	85	19	2	M1870
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	RANBP2 NUP54	5.88e-03	86	19	2	MM15413
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	RANBP2 HS6ST2 NUP54	6.42e-03	288	19	3	M16864
Pathway	WP_ANDROGEN_RECEPTOR_SIGNALING	NCOA1 SP1	6.56e-03	91	19	2	M39700
Pathway	REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS	RANBP2 NUP54	6.70e-03	92	19	2	MM14951
Pathway	REACTOME_SLC_TRANSPORTER_DISORDERS	RANBP2 NUP54	7.72e-03	99	19	2	M27474
Pathway	REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS	RANBP2 NUP54	8.03e-03	101	19	2	M27253
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS	RANBP2 NUP54	8.81e-03	106	19	2	M27458
Pathway	REACTOME_TRNA_PROCESSING	RANBP2 NUP54	9.63e-03	111	19	2	M27684
Pubmed	Interaction network of human early embryonic transcription factors.	ZFHX4 NCOA1 RANBP2 SS18L1 NUP54 RESF1	8.84e-08	351	23	6	38297188
Pubmed	Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1.	CDKN2C SP1	1.25e-06	3	23	2	12077144
Pubmed	Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factors.	NFYC SP1	1.25e-06	3	23	2	22412893
Pubmed	Human transcription factor protein interaction networks.	ZFHX4 NFYC NCOA1 SP1 SS18L1 NUP54 RESF1 DDX54	2.25e-06	1429	23	8	35140242
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	ZFHX4 NFYC NCOA1 BICRAL RESF1	5.43e-06	398	23	5	35016035
Pubmed	Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import.	RANBP2 NUP54	6.26e-06	6	23	2	11266456
Pubmed	The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression.	NCOA1 SP1	8.77e-06	7	23	2	17471507
Pubmed	A human MAP kinase interactome.	NFYC SP1 RANBP2 BICRAL NUP54	1.43e-05	486	23	5	20936779
Pubmed	Functional genomics identifies a mechanism for estrogen activation of the retinoic acid receptor alpha1 gene in breast cancer cells.	NCOA1 SP1	4.99e-05	16	23	2	15831516
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	DNAH9 RANBP2 RESF1	7.26e-05	123	23	3	26912792
Pubmed	Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes.	ZFHX4 HS6ST2	1.05e-04	23	23	2	27655933
Pubmed	Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.	RANBP2 NUP54	1.24e-04	25	23	2	10601273
Pubmed	Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1.	RANBP2 NUP54	1.35e-04	26	23	2	12228227
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	NCOA1 AMOTL1 RESF1	1.36e-04	152	23	3	38360978
Pubmed	Integrated structural analysis of the human nuclear pore complex scaffold.	RANBP2 NUP54	1.80e-04	30	23	2	24315095
Pubmed	The Structure Inventory of the Nuclear Pore Complex.	RANBP2 NUP54	1.80e-04	30	23	2	27016207
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	RANBP2 NUP54	2.90e-04	38	23	2	12791264
Pubmed	Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.	RANBP2 NUP54	3.21e-04	40	23	2	37516964
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	NCOA1 SP1 RESF1	4.76e-04	233	23	3	37704626
Interaction	CRX interactions	ZFHX4 NFYC CDKN2C NCOA1 SP1 SS18L1	3.19e-07	254	23	6	int:CRX
Interaction	BICRAL interactions	NFYC BICRAL SS18L1	1.56e-05	43	23	3	int:BICRAL
Interaction	SRF interactions	NFYC NCOA1 SP1 RESF1	1.73e-05	139	23	4	int:SRF
Interaction	EGR2 interactions	ZFHX4 NCOA1 SS18L1 RESF1	3.91e-05	171	23	4	int:EGR2
Interaction	NFYC interactions	NFYC SP1 BICRAL NUP54	4.47e-05	177	23	4	int:NFYC
Interaction	SOX7 interactions	ZFHX4 NCOA1 RESF1	1.08e-04	82	23	3	int:SOX7
Interaction	PGR interactions	NCOA1 SP1 DDX54	1.16e-04	84	23	3	int:PGR
Interaction	HDAC1 interactions	ZFHX4 NFYC SP1 RANBP2 BRINP1 NUP54 USP37	1.68e-04	1108	23	7	int:HDAC1
Interaction	DUXB interactions	ZFHX4 RESF1	1.89e-04	18	23	2	int:DUXB
Cytoband	1p32	NFYC CDKN2C	8.36e-05	27	23	2	1p32
Cytoband	Ensembl 112 genes in cytogenetic band chr1p32	CDKN2C TUT4	2.73e-03	155	23	2	chr1p32
Cytoband	Ensembl 112 genes in cytogenetic band chr8q21	ZFHX4 C8orf88	4.15e-03	192	23	2	chr8q21
GeneFamily	Nucleoporins	RANBP2 NUP54	3.59e-04	32	16	2	1051
Computational	Neighborhood of FANCL	SS18L1 USP37	4.28e-04	24	14	2	GCM_FANCL
Drug	Helveticoside [630-64-8]; Down 200; 7.4uM; HL60; HT_HG-U133A	CDKN2C NCOA1 SSH3 BICRAL	3.38e-05	186	23	4	2192_DN
Drug	trifluoperazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	CDKN2C SSH3 SUSD4 DDX54	4.07e-05	195	23	4	1649_DN
Drug	Etofenamate [30544-47-9]; Down 200; 10.8uM; MCF7; HT_HG-U133A	CDKN2C NCOA1 BICRAL DDX54	4.07e-05	195	23	4	7327_DN
Drug	sodium 4-phenylbutyrate; Up 200; 100uM; HL60; HG-U133A	NCOA1 RANBP2 SSH3 BRINP1	4.15e-05	196	23	4	363_UP
Drug	Amiprilose hydrochloride [60414-06-4]; Down 200; 11.8uM; PC3; HT_HG-U133A	SSH3 BRINP1 IL1RL1 DDX54	4.40e-05	199	23	4	4000_DN
Drug	Biperiden hydrochloride [1235-82-1]; Down 200; 11.4uM; MCF7; HT_HG-U133A	ZFHX4 SP1 BRINP1 TUT4	4.40e-05	199	23	4	5644_DN
Disease	Nasal Cavity Polyp	NCOA1 IL1RL1	8.42e-04	55	23	2	EFO_1000391
Disease	Self-injurious behavior	BRINP1 NUP54	1.68e-03	78	23	2	HP_0100716
Disease	Parkinson disease	SP1 BRINP1 RESF1	1.92e-03	321	23	3	MONDO_0005180
Disease	age at first birth measurement	HS6ST2 NUP54	3.92e-03	120	23	2	EFO_0009101
Disease	Malignant neoplasm of breast	NFYC CDKN2C NCOA1 DNAH9	8.89e-03	1074	23	4	C0006142

Protein segments in the cluster

Peptide	Gene	Start	Entry
SAVQQVNQSYTQGGQ	BRINP1	671	O60477
AQSQFFRGQQQQQQQ	AMOTL1	196	Q8IY63
FRGQQQQQQQQGAVG	AMOTL1	201	Q8IY63
ANQGQNTNNSQFVIT	RANBP2	3161	P49792
QAFSQGLNEQQQQQS	C8orf88	56	P0DMB2
IARFQQGQQGRQEQQ	DDX54	601	Q8TDD1
VQQGQQQFSQFTDGQ	NFYC	301	Q13952
QQFSQFTDGQRNSVQ	NFYC	306	Q13952
GFGGFNTQQQQQTTL	NUP54	86	Q7Z3B4
QNNVNVNAQNGFGRT	CDKN2C	26	P42773
IQQEEGQNQSFSNGL	IL1RL1	266	Q01638
GQQNTYNVNNLGIQQ	BICRAL	321	Q6AI39
LQTHFQSQGQGQSQN	HS6ST2	526	Q96MM7
NQNFHNVSLGQGQEV	DNAH9	3926	Q9NYC9
QQPQQQQQQHGVFFE	MN1	301	Q10571
QGNQGLNQSFSEQQV	RESF1	181	Q9HCM1
QQGAIGNNNVFSQAV	NCOA1	1286	Q15788
GNNNVFSQAVQNQPT	NCOA1	1291	Q15788
QAGQQKEGEQNQQTQ	SP1	381	P08047
TQAFQEQEQGQGQGQ	SSH3	616	Q8TE77
SVFNGNVTNQNQNFN	CLEC5A	146	Q9NY25
NVTNQNQNFNCATIG	CLEC5A	151	Q9NY25
SQQQAGYQQGAAQQQ	SS18L1	311	O75177
NVQNLQNGNGEQVFG	ZFHX4	726	Q86UP3
DGFLEQQQQQQQPQS	SUSD4	11	Q5VX71
QQQQLQGFSNLGNTC	USP37	336	Q86T82
NAQQVAGSAQQQGDQ	TUT4	1396	Q5TAX3