Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC9A9 ABCA4 CFTR GRIN2A AQP8 RTBDN SLC26A1 RHCE RHD CHRND SLC52A3 SLC6A2 CLCN4 SLC24A4 SLC16A5 ANO6 GJD3 SLC22A2 HPX SLC25A28	1.24e-05	1180	115	20	GO:0022857
GeneOntologyMolecularFunction	transporter activity	SLC9A9 ABCA4 CFTR GRIN2A AQP8 RTBDN SLC26A1 RHCE RHD CHRND SLC52A3 SLC6A2 CLCN4 SLC24A4 SLC16A5 ANO6 GJD3 SLC22A2 HPX OSBPL8 SLC25A28	1.32e-05	1289	115	21	GO:0005215
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	ADGRG3 OR5AC1 HTR2B FZD3 OR5G3 OR2AP1 MLNR OR5H15 OR5H14 GRIN2A GRM6 CHRND NRP2 OR52E2 FZD9 TGFBR2 CD300LD OR5AC2 CSF1R OR5H1 EPHA1	2.73e-05	1353	115	21	GO:0004888
GeneOntologyMolecularFunction	delta14-sterol reductase activity	LBR TM7SF2	3.29e-05	2	115	2	GO:0050613
GeneOntologyMolecularFunction	ammonium channel activity	AQP8 RHCE RHD	3.94e-05	12	115	3	GO:0008519
GeneOntologyMolecularFunction	vitamin transmembrane transporter activity	ABCA4 RTBDN SLC52A3 SLC22A2	5.33e-05	36	115	4	GO:0090482
GeneOntologyMolecularFunction	odorant binding	OR5AC1 OR5G3 OR5H15 OR5H14 OR5AC2 OR5H1	9.39e-05	127	115	6	GO:0005549
GeneOntologyMolecularFunction	alkaline phosphatase activity	ALPI ALPG	4.86e-04	6	115	2	GO:0004035
GeneOntologyMolecularFunction	riboflavin transmembrane transporter activity	RTBDN SLC52A3	4.86e-04	6	115	2	GO:0032217
GeneOntologyMolecularFunction	G protein-coupled receptor activity	ADGRG3 OR5AC1 HTR2B FZD3 OR5G3 OR2AP1 MLNR OR5H15 OR5H14 GRM6 OR52E2 FZD9 OR5AC2 OR5H1	5.60e-04	884	115	14	GO:0004930
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	CFTR SLC26A1 SLC6A2 CLCN4 ANO6	7.86e-04	125	115	5	GO:0015108
GeneOntologyMolecularFunction	channel activity	CFTR GRIN2A AQP8 RHCE RHD CHRND CLCN4 SLC24A4 ANO6 GJD3	9.16e-04	525	115	10	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CFTR GRIN2A AQP8 RHCE RHD CHRND CLCN4 SLC24A4 ANO6 GJD3	9.30e-04	526	115	10	GO:0022803
GeneOntologyMolecularFunction	amine transmembrane transporter activity	AQP8 SLC22A2	1.15e-03	9	115	2	GO:0005275
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC9A9 CFTR GRIN2A AQP8 SLC26A1 RHCE RHD SLC6A2 CLCN4 SLC24A4 ANO6 SLC25A28	1.42e-03	758	115	12	GO:0015318
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	NRP2 TGFBR2 CSF1R EPHA1	1.48e-03	85	115	4	GO:0019199
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	CFTR GRIN2A RTBDN SLC26A1 SLC52A3 SLC16A5 SLC22A2	1.55e-03	293	115	7	GO:0008514
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCN4 ANO6	1.75e-03	11	115	2	GO:0005247
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC9A9 ABCA4 CFTR SLC26A1 SLC6A2 CLCN4 SLC24A4 SLC16A5 SLC22A2	1.77e-03	477	115	9	GO:0022804
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	CFTR SLC26A1 SLC6A2 CLCN4 ANO6	1.82e-03	151	115	5	GO:0008509
GeneOntologyBiologicalProcess	cholesterol biosynthetic process	CFTR SREBF2 AQP8 LBR TM7SF2	3.53e-05	65	118	5	GO:0006695
GeneOntologyBiologicalProcess	secondary alcohol biosynthetic process	CFTR SREBF2 AQP8 LBR TM7SF2	3.53e-05	65	118	5	GO:1902653
GeneOntologyBiologicalProcess	ammonium transmembrane transport	AQP8 RHCE RHD	5.01e-05	13	118	3	GO:0072488
GeneOntologyBiologicalProcess	sterol biosynthetic process	CFTR SREBF2 AQP8 LBR TM7SF2	5.80e-05	72	118	5	GO:0016126
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	CYP8B1 SYNE1 CFTR SREBF2 TMEM214 GRIN2A AQP8 LBR GRM6 FZD9 LMF2 LCTL CLCN4 G6PC3 ZDHHC22 OSBPL8 TM7SF2 CYP4F12 RNF139	1.40e-04	1327	117	19	GO:0042175
GeneOntologyCellularComponent	endoplasmic reticulum membrane	CYP8B1 CFTR SREBF2 TMEM214 GRIN2A AQP8 LBR GRM6 FZD9 LMF2 LCTL CLCN4 G6PC3 ZDHHC22 OSBPL8 TM7SF2 CYP4F12 RNF139	3.01e-04	1293	117	18	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	CYP8B1 CFTR SREBF2 TMEM214 GRIN2A AQP8 LBR GRM6 FZD9 LMF2 LCTL CLCN4 G6PC3 ZDHHC22 OSBPL8 TM7SF2 CYP4F12 RNF139	3.18e-04	1299	117	18	GO:0098827
Domain	Sterol_reductase_CS	LBR TM7SF2	1.03e-04	3	110	2	IPR018083
Domain	ERG4_ERG24	LBR TM7SF2	1.03e-04	3	110	2	PF01222
Domain	Ergosterol_biosynth_ERG4_ERG24	LBR TM7SF2	1.03e-04	3	110	2	IPR001171
Domain	STEROL_REDUCT_2	LBR TM7SF2	1.03e-04	3	110	2	PS01018
Domain	STEROL_REDUCT_1	LBR TM7SF2	1.03e-04	3	110	2	PS01017
Domain	GRAM	TBC1D8B TBC1D9 TBC1D8	1.05e-04	16	110	3	SM00568
Domain	TBC	TBC1D8B TBC1D9 TBC1D8 GRTP1	1.97e-04	49	110	4	SM00164
Domain	Alk_phosphatase	ALPI ALPG	2.05e-04	4	110	2	PF00245
Domain	Alkaline_phosphatase_AS	ALPI ALPG	2.05e-04	4	110	2	IPR018299
Domain	Alkaline_phosphatase	ALPI ALPG	2.05e-04	4	110	2	IPR001952
Domain	alkPPc	ALPI ALPG	2.05e-04	4	110	2	SM00098
Domain	ALKALINE_PHOSPHATASE	ALPI ALPG	2.05e-04	4	110	2	PS00123
Domain	RabGAP-TBC	TBC1D8B TBC1D9 TBC1D8 GRTP1	2.67e-04	53	110	4	PF00566
Domain	GRAM	TBC1D8B TBC1D9 TBC1D8	2.82e-04	22	110	3	PF02893
Domain	GRAM	TBC1D8B TBC1D9 TBC1D8	2.82e-04	22	110	3	IPR004182
Domain	TBC_RABGAP	TBC1D8B TBC1D9 TBC1D8 GRTP1	3.08e-04	55	110	4	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D8B TBC1D9 TBC1D8 GRTP1	3.08e-04	55	110	4	IPR000195
Domain	Hemopexin-like_dom	HPX MMP9 MMP19	3.23e-04	23	110	3	IPR000585
Domain	Hemopexin-like_repeat	HPX MMP9 MMP19	3.23e-04	23	110	3	IPR018487
Domain	Hemopexin	HPX MMP9 MMP19	3.23e-04	23	110	3	PF00045
Domain	HEMOPEXIN	HPX MMP9 MMP19	3.23e-04	23	110	3	PS00024
Domain	-	HPX MMP9 MMP19	3.23e-04	23	110	3	2.110.10.10
Domain	HEMOPEXIN_2	HPX MMP9 MMP19	3.23e-04	23	110	3	PS51642
Domain	HX	HPX MMP9 MMP19	3.23e-04	23	110	3	SM00120
Domain	Ammonium_transpt	RHCE RHD	3.40e-04	5	110	2	IPR001905
Domain	Ammonium_transp	RHCE RHD	3.40e-04	5	110	2	PF00909
Domain	NH4_transpt_AmtB-like_dom	RHCE RHD	3.40e-04	5	110	2	IPR024041
Domain	RhesusRHD	RHCE RHD	3.40e-04	5	110	2	IPR002229
Domain	-	RHCE RHD	7.08e-04	7	110	2	1.10.3430.10
Domain	Ammonium/urea_transptr	RHCE RHD	7.08e-04	7	110	2	IPR029020
Domain	Cyt_P450_E_grp-IV	CYP8B1 CYP4F12	1.50e-03	10	110	2	IPR002403
Domain	Frizzled	FZD3 FZD9	1.83e-03	11	110	2	IPR000539
Domain	Frizzled	FZD3 FZD9	1.83e-03	11	110	2	PF01534
Domain	Frizzled	FZD3 FZD9	1.83e-03	11	110	2	SM01330
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DNAH6	2.99e-03	14	110	2	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DNAH6	2.99e-03	14	110	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DNAH6	2.99e-03	14	110	2	IPR013602
Domain	DHC_N2	DNAH5 DNAH6	2.99e-03	14	110	2	PF08393
Domain	MT	DNAH5 DNAH6	2.99e-03	14	110	2	PF12777
Domain	AAA_8	DNAH5 DNAH6	2.99e-03	14	110	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH5 DNAH6	2.99e-03	14	110	2	IPR011704
Domain	AAA_5	DNAH5 DNAH6	2.99e-03	14	110	2	PF07728
Domain	DHC_fam	DNAH5 DNAH6	3.43e-03	15	110	2	IPR026983
Domain	Dynein_heavy_dom	DNAH5 DNAH6	3.43e-03	15	110	2	IPR004273
Domain	Dynein_heavy	DNAH5 DNAH6	3.43e-03	15	110	2	PF03028
Domain	Frizzled/SFRP	FZD3 FZD9	3.91e-03	16	110	2	IPR015526
Domain	Hemopexin_CS	HPX MMP9	4.41e-03	17	110	2	IPR018486
Domain	-	DGKB TBC1D8B CALML6 TBC1D9 TBC1D8 SPATA21	4.49e-03	261	110	6	1.10.238.10
Domain	GPCR_2_secretin-like	ADGRG3 FZD3 FZD9	5.33e-03	60	110	3	IPR000832
Domain	GPCR_2-like	ADGRG3 FZD3 FZD9	5.33e-03	60	110	3	IPR017981
Domain	PRAME_family	PRAMEF10 PRAMEF17	5.51e-03	19	110	2	IPR026271
Domain	G_PROTEIN_RECEP_F2_4	ADGRG3 FZD3 FZD9	5.58e-03	61	110	3	PS50261
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ANKS6 EPPK1 KIF26A FBXL12 SPATA20 ECE1 TBC1D9 KIAA2013 SLC52A3 TAOK2 GRTP1 SLC16A5 TNK2 ZER1 MED13	7.20e-06	1105	121	15	35748872
Pubmed	TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors.	TGFBR2 ALPI ALPG	8.83e-06	12	121	3	31289197
Pubmed	Organization of the gene (RHCE) encoding the human blood group RhCcEe antigens and characterization of the promoter region.	RHCE RHD	1.20e-05	2	121	2	8188244
Pubmed	Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis.	LBR TM7SF2	1.20e-05	2	121	2	16784888
Pubmed	DCS-1, DCS-2, and DFV share amino acid substitutions at the extracellular RhD protein vestibule.	RHCE RHD	1.20e-05	2	121	2	17900276
Pubmed	RHD and RHCE molecular analysis in weak D blood donors and in patients with Rh antibodies against their own corresponding Rh antigen.	RHCE RHD	1.20e-05	2	121	2	32697929
Pubmed	HEM dysplasia and ichthyosis are likely laminopathies and not due to 3beta-hydroxysterol Delta14-reductase deficiency.	LBR TM7SF2	1.20e-05	2	121	2	17403717
Pubmed	Review: the molecular basis of the Rh blood group phenotypes.	RHCE RHD	1.20e-05	2	121	2	15373666
Pubmed	Intron 4 of the RH Gene in Han Chinese, Tibetan, and Mongol Populations.	RHCE RHD	1.20e-05	2	121	2	26579938
Pubmed	Accurate long-read sequencing allows assembly of the duplicated RHD and RHCE genes harboring variants relevant to blood transfusion.	RHCE RHD	1.20e-05	2	121	2	34968422
Pubmed	Regarding the size of Rh proteins.	RHCE RHD	1.20e-05	2	121	2	1898705
Pubmed	PCR screening for common weak D types shows different distributions in three Central European populations.	RHCE RHD	1.20e-05	2	121	2	11161244
Pubmed	Identification of Potential Leukocyte Biomarkers Related to Drug Recovery of CFTR: Clinical Applications in Cystic Fibrosis.	CFTR MMP9	1.20e-05	2	121	2	33920274
Pubmed	RH diversity in Mali: characterization of a new haplotype RHDDIVa/RHCEceTI(D2).	RHCE RHD	1.20e-05	2	121	2	25857637
Pubmed	The low-prevalence Rh antigen STEM (RH49) is encoded by two different RHCEce818T alleles that are often in cis to RHDDOL.	RHCE RHD	1.20e-05	2	121	2	22738288
Pubmed	Multiple Rh messenger RNA isoforms are produced by alternative splicing.	RHCE RHD	1.20e-05	2	121	2	1379850
Pubmed	Characterization of the mouse Rh blood group gene.	RHCE RHD	1.20e-05	2	121	2	10329015
Pubmed	Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box.	SREBF2 TM7SF2	1.20e-05	2	121	2	20138239
Pubmed	RHCEceMO is frequently in cis to RHDDAU0 and encodes a hr(S) -, hr(B) -, RH:-61 phenotype in black persons: clinical significance.	RHCE RHD	1.20e-05	2	121	2	23772606
Pubmed	Determination of the N-terminal sequence of human red cell Rh(D) polypeptide and demonstration that the Rh(D), (c), and (E) antigens are carried by distinct polypeptide chains.	RHCE RHD	1.20e-05	2	121	2	3135863
Pubmed	Tracking the immunopathological response to Pseudomonas aeruginosa during respiratory infections.	CFTR MMP9	1.20e-05	2	121	2	26883959
Pubmed	Sequences and evolution of mammalian RH gene transcripts and proteins.	RHCE RHD	1.20e-05	2	121	2	9811965
Pubmed	Rare RHCE phenotypes in black individuals of Afro-Caribbean origin: identification and transfusion safety.	RHCE RHD	1.20e-05	2	121	2	12393640
Pubmed	Molecular genetic basis of the human Rhesus blood group system.	RHCE RHD	1.20e-05	2	121	2	8220426
Pubmed	Isolation of a new cDNA clone encoding an Rh polypeptide associated with the Rh blood group system.	RHCE RHD	1.20e-05	2	121	2	7916743
Pubmed	RHDDOL1 and RHDDOL2 encode a partial D antigen and are in cis with the rare RHCE*ceBI allele in people of African descent.	RHCE RHD	1.20e-05	2	121	2	22690701
Pubmed	No Distinction of Orthology/Paralogy between Human and Chimpanzee Rh Blood Group Genes.	RHCE RHD	1.20e-05	2	121	2	26872772
Pubmed	RHCEceTI encodes partial c and partial e and is often in cis to RHDDIVa.	RHCE RHD	1.20e-05	2	121	2	22804620
Pubmed	Intricate combinatorial patterns of exon splicing generate multiple Rh-related isoforms in human erythroid cells.	RHCE RHD	1.20e-05	2	121	2	7789951
Pubmed	E variants found in Japanese and c antigenicity alteration without substitution in the second extracellular loop.	RHCE RHD	1.20e-05	2	121	2	11724987
Pubmed	The Rh blood group system: a review.	RHCE RHD	1.20e-05	2	121	2	10627438
Pubmed	Sorting out co-occurrence of rare monogenic retinopathies: Stargardt disease co-existing with congenital stationary night blindness.	ABCA4 GRM6	1.20e-05	2	121	2	24397708
Pubmed	Polymorphisms in the promoter regions of RHD and RHCE genes in the Chinese Han population.	RHCE RHD	1.20e-05	2	121	2	37823181
Pubmed	Sequence diversity of the Rh blood group system in Basques.	RHCE RHD	1.20e-05	2	121	2	30089826
Pubmed	Transfusion strategy for weak D Type 4.0 based on RHD alleles and RH haplotypes in Tunisia.	RHCE RHD	1.20e-05	2	121	2	29193104
Pubmed	Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis.	LBR TM7SF2	1.20e-05	2	121	2	18785926
Pubmed	RHCE variants inherited with altered RHD alleles in Brazilian blood donors.	RHCE RHD	1.20e-05	2	121	2	27111588
Pubmed	Alteration of RH gene structure and expression in human dCCee and DCW-red blood cells: phenotypic homozygosity versus genotypic heterozygosity.	RHCE RHD	1.20e-05	2	121	2	8822955
Pubmed	Genetic recombination at the human RH locus: a family study of the red-cell Evans phenotype reveals a transfer of exons 2-6 from the RHD to the RHCE gene.	RHCE RHD	1.20e-05	2	121	2	8808597
Pubmed	Molecular background of Rh D-positive, D-negative, D(el) and weak D phenotypes in Chinese.	RHCE RHD	1.20e-05	2	121	2	12201845
Pubmed	Variant RH alleles and Rh immunisation in patients with sickle cell disease.	RHCE RHD	1.20e-05	2	121	2	24960646
Pubmed	Mitochondrial aquaporin-8 is involved in SREBP-controlled hepatocyte cholesterol biosynthesis.	SREBF2 AQP8	1.20e-05	2	121	2	30579780
Pubmed	Comprehensive phenotypic and molecular investigation of RhD and RhCE variants in Moroccan blood donors.	RHCE RHD	1.20e-05	2	121	2	30418133
Pubmed	A convenient qualitative and quantitative method to investigate RHD-RHCE hybrid genes.	RHCE RHD	1.20e-05	2	121	2	23550903
Pubmed	Molecular cloning and primary structure of the human blood group RhD polypeptide.	RHCE RHD	1.20e-05	2	121	2	1438298
Pubmed	Molecular background of D(C)(e) haplotypes within the white population.	RHCE RHD	1.20e-05	2	121	2	12084172
Pubmed	Anoctamin 6 is an essential component of the outwardly rectifying chloride channel.	CFTR ANO6	1.20e-05	2	121	2	22006324
Pubmed	The analysis of nucleotide substitutions, gaps, and recombination events between RHD and RHCE genes through complete sequencing.	RHCE RHD	1.20e-05	2	121	2	10924335
Pubmed	A two-locus gene conversion model with selection and its application to the human RHCE and RHD genes.	RHCE RHD	1.20e-05	2	121	2	12857961
Pubmed	Specific amino acid substitutions cause distinct expression of JAL (RH48) and JAHK (RH53) antigens in RhCE and not in RhD.	RHCE RHD	1.20e-05	2	121	2	20233350
Pubmed	A recombination hot spot in the Rh genes revealed by analysis of unrelated donors with the rare D-- phenotype.	RHCE RHD	1.20e-05	2	121	2	8900235
Pubmed	RHDweak partial 4.0 is associated with an altered RHCEce(48C, 105T, 733G, 744C, 1025T) allele in the Tunisian population.	RHCE RHD	1.20e-05	2	121	2	23742316
Pubmed	A comprehensive survey of both RHD and RHCE allele frequencies in sub-Saharan Africa.	RHCE RHD	1.20e-05	2	121	2	24033223
Pubmed	Lamin B receptor regulates the growth and maturation of myeloid progenitors via its sterol reductase domain: implications for cholesterol biosynthesis in regulating myelopoiesis.	LBR TM7SF2	1.20e-05	2	121	2	22140257
Pubmed	Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.	TBC1D8B TBC1D9 TBC1D8 GRTP1	1.55e-05	43	121	4	19077034
Pubmed	Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.	SLC9A9 SYNE1 TGFBR2	2.70e-05	17	121	3	17903302
Pubmed	Plasma membrane-localized TMEM16 proteins are indispensable for expression of CFTR.	CFTR ANO6	3.59e-05	3	121	2	30915480
Pubmed	Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally.	LBR TM7SF2	3.59e-05	3	121	2	31911440
Pubmed	Human Host Defense Peptide LL-37 Suppresses TNFα-Mediated Matrix Metalloproteinases MMP9 and MMP13 in Human Bronchial Epithelial Cells.	CAMP MMP9	3.59e-05	3	121	2	38471488
Pubmed	A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23.	FZD3 FZD9	3.59e-05	3	121	2	9147651
Pubmed	Evolutionary history of the Rh blood group-related genes in vertebrates.	RHCE RHD	3.59e-05	3	121	2	10970100
Pubmed	Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene.	RHCE RHD	3.59e-05	3	121	2	9705835
Pubmed	Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells.	ABCA4 CFTR	3.59e-05	3	121	2	22572847
Pubmed	Organic pyrophosphates as substrates for human alkaline phosphatases.	ALPI ALPG	3.59e-05	3	121	2	16742561
Pubmed	ACK1 tyrosine kinase interacts with histone demethylase KDM3A to regulate the mammary tumor oncogene HOXA1.	KDM3A TNK2	3.59e-05	3	121	2	25148682
Pubmed	DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia.	DNAH5 DNAH6	3.59e-05	3	121	2	26918822
Pubmed	The members of the RH gene family (RH50 and RH30) followed different evolutionary pathways.	RHCE RHD	3.59e-05	3	121	2	9929383
Pubmed	Cutting Edge: MMP-9 inhibits IL-23p19 expression in dendritic cells by targeting membrane stem cell factor affecting lung IL-17 response.	IL23A MMP9	3.59e-05	3	121	2	24829419
Pubmed	Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane.	RHCE RHD	3.59e-05	3	121	2	3146980
Pubmed	Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases.	ALPI ALPG	3.59e-05	3	121	2	3443302
Pubmed	The intranuclear PEX domain of MMP involves proliferation, migration, and metastasis of aggressive adenocarcinoma cells.	HPX MMP9	3.59e-05	3	121	2	29761931
Pubmed	Generation and characterisation of Rhd and Rhag null mice.	RHCE RHD	3.59e-05	3	121	2	19807729
Pubmed	Relationship of interleukin-23 with matrix metalloproteinase-9, pentraxin-3, sleep quality and prostate size in benign prostatic hyperplasia.	IL23A MMP9	3.59e-05	3	121	2	35092070
Pubmed	Hydrophobic cluster analysis and modeling of the human Rh protein three-dimensional structures.	RHCE RHD	3.59e-05	3	121	2	16584906
Pubmed	Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.	ALPI ALPG	3.59e-05	3	121	2	19407215
Pubmed	Serum levels of matrix metalloproteinases 2 and 9 and TGFBR2 gene screening in patients with ascending aortic dilatation.	TGFBR2 MMP9	3.59e-05	3	121	2	24093773
Pubmed	Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta.	CAMP TGFBR2	3.59e-05	3	121	2	30594464
Pubmed	Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes.	ALPI ALPG	3.59e-05	3	121	2	2286375
Pubmed	The human lamin B receptor/sterol reductase multigene family.	LBR TM7SF2	3.59e-05	3	121	2	9878250
Pubmed	Intestinal Alkaline Phosphatase Regulates Tight Junction Protein Levels.	ALPI ALPG	3.59e-05	3	121	2	27106638
Pubmed	Effects of disruption of the embryonic alkaline phosphatase gene on preimplantation development of the mouse.	ALPI ALPG	3.59e-05	3	121	2	10767088
Pubmed	MUSEAP, a novel reporter gene for the study of long-term gene expression in immunocompetent mice.	ALPI ALPG	3.59e-05	3	121	2	11722850
Pubmed	Induction of a massive endoplasmic reticulum and perinuclear space expansion by expression of lamin B receptor mutants and the related sterol reductases TM7SF2 and DHCR7.	LBR TM7SF2	3.59e-05	3	121	2	19940018
Pubmed	A novel phosphatase upregulated in Akp3 knockout mice.	ALPI ALPG	3.59e-05	3	121	2	17901166
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	ANKS6 WDR7 SREBF2 TMEM214 LBR ECE1 ANO6 OSBPL8 HEATR5B	7.06e-05	504	121	9	34432599
Pubmed	Interactions between CD36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet.	ALPI ALPG	7.17e-05	4	121	2	21900644
Pubmed	Novel Role of the ALPI Gene Associated with Constipation Caused by Complement Component 3 Deficiency.	ALPI ALPG	7.17e-05	4	121	2	39273477
Pubmed	Entire sequence of a mouse chromosomal segment containing the gene Rhced and a comparative analysis of the homologous human sequence.	RHCE RHD	7.17e-05	4	121	2	12459264
Pubmed	Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas.	CFTR AQP8	7.17e-05	4	121	2	12801959
Pubmed	The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.	SREBF2 RNF139	7.17e-05	4	121	2	19706601
Pubmed	Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.	ALPI ALPG	7.17e-05	4	121	2	9056646
Pubmed	Structural evidence of functional divergence in human alkaline phosphatases.	ALPI ALPG	7.17e-05	4	121	2	12372831
Pubmed	Heterogeneity among cells that express osteoclast-associated genes in developing bone.	CSF1R MMP9	7.17e-05	4	121	2	9421432
Pubmed	Neutrophils from F508del cystic fibrosis patients produce IL-17A and express IL-23 - dependent IL-17RC.	CFTR IL23A	7.17e-05	4	121	2	27155366
Pubmed	Stage-specific expression patterns of alkaline phosphatase during development of the first arch skeleton in inbred C57BL/6 mouse embryos.	ALPI ALPG	7.17e-05	4	121	2	9061447
Pubmed	HLA-DRB1 molecules and the presentation of anchor peptides from RhD, RhCE, and KEL proteins.	RHCE RHD	7.17e-05	4	121	2	33675036
Pubmed	Confirmation of quantitative trait loci for ethanol sensitivity in long-sleep and short-sleep mice.	CHRND SLC6A2	7.17e-05	4	121	2	9049627
Pubmed	Association between ABO, Rhesus blood group systems and haemoglobin genotype among confirmed HIV/AIDS-TB co-infected patients in Enugu Urban, Nigeria.	RHCE RHD	7.17e-05	4	121	2	16722361
Pubmed	Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.	SLC9A9 ABCA4 SYNE1	1.13e-04	27	121	3	18649358
Pubmed	Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.	ECE1 NRP2 TGFBR2	1.13e-04	27	121	3	24586749
Cytoband	Ensembl 112 genes in cytogenetic band chr3q11	OR5AC1 OR5H15 OR5H14 OR5AC2 OR5H1	3.34e-07	54	121	5	chr3q11
Cytoband	Ensembl 112 genes in cytogenetic band chr2p11	KDM3A IGKV2D-40 IGKV2D-29 DNAH6 IGKV2-40 IGKV2-29	2.29e-05	213	121	6	chr2p11
Cytoband	3q12.1	OR5H15 OR5H14 OR5AC2	2.29e-05	21	121	3	3q12.1
Cytoband	2p12	IGKV2D-40 IGKV2D-29 IGKV2-40 IGKV2-29	2.70e-04	117	121	4	2p12
Cytoband	Ensembl 112 genes in cytogenetic band chr2q37	HTR2B ESPNL CHRND ALPI ALPG	3.46e-04	226	121	5	chr2q37
Cytoband	12q14	OSBPL8 MMP19	3.73e-04	11	121	2	12q14
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	PRAMEF10 PRAMEF17 ECE1 CALML6 RHCE KIAA2013 RHD SPATA21	4.66e-04	681	121	8	chr1p36
Cytoband	22q13	CYP2D7 SREBF2	2.15e-03	26	121	2	22q13
Cytoband	3q11.2	OR5AC1 OR5H1	2.15e-03	26	121	2	3q11.2
GeneFamily	Olfactory receptors, family 5	OR5AC1 OR5G3 OR5H15 OR5H14 OR5AC2 OR5H1	2.28e-05	112	92	6	152
GeneFamily	WD repeat domain containing\|GRAM domain containing\|BEACH domain containing	TBC1D8B TBC1D9 TBC1D8	3.51e-05	13	92	3	1146
GeneFamily	Alkaline phosphatases	ALPI ALPG	1.53e-04	4	92	2	1072
GeneFamily	Immunoglobulin kappa locus at 2p11.2	IGKV2D-40 IGKV2D-29 IGKV2-40 IGKV2-29	8.49e-04	83	92	4	351
GeneFamily	Solute carriers	SLC9A9 SLC26A1 SLC52A3 SLC6A2 SLC24A4 SLC16A5 SLC22A2 SLC25A28	9.10e-04	395	92	8	752
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD3 FZD9	1.37e-03	11	92	2	286
GeneFamily	Dyneins, axonemal	DNAH5 DNAH6	3.31e-03	17	92	2	536
GeneFamily	EF-hand domain containing	DGKB TBC1D8B CALML6 TBC1D9 SPATA21	5.22e-03	219	92	5	863
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP9 MMP19	6.57e-03	24	92	2	891
GeneFamily	PRAME family	PRAMEF10 PRAMEF17	6.57e-03	24	92	2	686
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FKBP6 HTR2B CFTR TBC1D9 SLC6A2 FZD9 DNAH5	2.07e-07	154	120	7	1e32969bee810adaf2d560f0824a16227df513d8
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM3A ADGRG3 SYNE1 CAMP TGFBR2 CD300LD CSF1R	2.79e-07	161	120	7	3f3a2148c8d65e6a06f8d8116a3aa58dda17d618
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC9A9 PRSS57 CWH43 CYP8B1 ECE1 TBC1D9 TBC1D8	4.37e-07	172	120	7	a5344760b10ecdc0101f78b93b8fc0f8107068c5
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG3 HTR2B NRP2 GJD3 SLC22A2 EGFL7 DNAH6	5.10e-07	176	120	7	460cb302c5b3d609c65b924e1d4e8ea057a68485
ToppCell	Sigmoid-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	MAGED1 FZD3 SAMD12 CLCN4 TM7SF2 ZER1 ROBO3	1.20e-06	200	120	7	09deb831fc2c8a8867cc850f3aa094a5e48489ff
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HTR2B SAMD12 ECE1 NRP2 SLC6A2 EGFL7	6.59e-06	169	120	6	58136b8a0bf2dab45c91a053ef7225ea49ccb871
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HTR2B SAMD12 ECE1 NRP2 SLC6A2 EGFL7	6.59e-06	169	120	6	04c6ed38e1d1befba5ef5f37a3c1e045a0b163d6
ToppCell	droplet-Spleen-nan-3m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 PRSS57 SYNE1 CAMP ADH1A MMP9	6.81e-06	170	120	6	dbd6c9c7be824a1ff1b31af791064127cafbd194
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRSS57 CWH43 CYP8B1 ECE1 TBC1D9 CHSY3	7.53e-06	173	120	6	70c0c13febd28b395fb3171ec8d7fbbc6c9d4eb7
ToppCell	COVID-19-Heart-Lymph_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADGRG3 CYP8B1 NRP2 FZD9 TGFBR2 IGKV2D-40	8.58e-06	177	120	6	326fde0734ef0d7272693966d346ca479b9d8147
ToppCell	facs-Diaphragm-Limb_Muscle-18m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS57 CAMP PHGDH HPX EGFL7 MMP9	8.86e-06	178	120	6	40bd605b801d9ae76cffc8f62836092fc2b06812
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRG3 HYAL1 RHCE NRP2 GJD3 EGFL7	9.15e-06	179	120	6	abc6797bd3884aa75dca58fcb2523ee321243ab1
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRG3 HYAL1 RHCE NRP2 GJD3 EGFL7	9.15e-06	179	120	6	0b996d6e881f31e6b80d359f7caac70ecdeb9982
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HYAL1 RHCE NRP2 TGFBR2 EGFL7 ALPG	9.15e-06	179	120	6	1c0c0647a111f691dae55f4ed8c51006059ce020
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA4 CYP8B1 FZD9 CLCN4 GJD3 EGFL7	9.15e-06	179	120	6	40c65e8623547aeb80f9cd2366e29072467ce069
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPPK1 LRRC10B PPOX TBC1D8 DNAH5 DNAH6	9.44e-06	180	120	6	1f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HTR2B SAMD12 ECE1 NRP2 SLC6A2 EGFL7	1.04e-05	183	120	6	fc9a7ba148c22d0c8a46f6bc56c772929ac496f7
ToppCell	facs-Heart-LA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 HYAL1 SAMD12 ECE1 ADH1A EGFL7	1.10e-05	185	120	6	1ecfca049c0c1110fd1b2256db7cb7abda6afb04
ToppCell	facs-Heart-LA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 HYAL1 SAMD12 ECE1 ADH1A EGFL7	1.10e-05	185	120	6	b6df1412b579d40ed5df806f9c54bd1fbb9a1e15
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 PRSS57 TMEM214 GRM6 PHGDH G6PC3	1.21e-05	188	120	6	7e27e49ec1eb02fb74c86ec2ccb84751bc778b21
ToppCell	droplet-Marrow-nan-21m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 PRSS57 TMEM214 GRM6 PHGDH G6PC3	1.21e-05	188	120	6	4b14c3ad80507245564d5be96d33fd9361f67dd0
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRRC10B PPOX TBC1D8 SLC22A2 DNAH5 DNAH6	1.25e-05	189	120	6	b4b93bd10b7e3cc16e54ff73beac230f519c010a
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KIF26A CYP8B1 RHCE RHD ADH1A HPX	1.28e-05	190	120	6	a34293601aefe5fb5c400c14091294b9ddaa195b
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HTR2B KIF26A SAMD12 ECE1 SLC6A2 EGFL7	1.32e-05	191	120	6	b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)\|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PRSS57 SYNE1 CAMP PGAP4 LBR MMP9	1.36e-05	192	120	6	072281344d58e85c9a290750b488d0c101f75d54
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRG3 ABCA4 CYP8B1 NRP2 FZD9 EGFL7	1.53e-05	196	120	6	09a7edf4a7defb7fe70d9777dd9500ee8421ff31
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRG3 ABCA4 CYP8B1 NRP2 FZD9 EGFL7	1.53e-05	196	120	6	e50d2c66d5c5cd25fdfecdcc4c8506a1d0a85755
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1\|Striatum / BrainAtlas - Mouse McCarroll V32	CFTR DGKB SLC24A4 SPATA21 ROBO3	4.74e-05	146	120	5	7b863f9bc63dc1afe015a18a70cd6ed0b71d1f09
ToppCell	facs-Skin-nan-18m-Myeloid-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D9 CD300LD CSF1R MMP9 MMP19	5.22e-05	149	120	5	23a1b95c12f2e3708dc003e13fab423e89821f11
ToppCell	facs-Skin-nan-18m-Myeloid-macrophage\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D9 CD300LD CSF1R MMP9 MMP19	5.22e-05	149	120	5	c53a3226adc8fd0eaaa842b6a96442287580cbe0
ToppCell	facs-Skin-nan-18m-Myeloid\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D9 CD300LD CSF1R MMP9 MMP19	5.22e-05	149	120	5	bb18a18b891af85849b9658d774053f839c9a8e1
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADGRG3 SYNE1 CAMP GRM6 MMP9	5.22e-05	149	120	5	c9334f319a0c943268e54b6f0c9446736172c3a9
ToppCell	Myeloid-Myeloid-E_(Neutrophils)\|Myeloid / shred on cell class and cell subclass (v4)	SYNE1 CAMP LBR CD300LD MMP9	5.39e-05	150	120	5	1bffb8d86b737ac43be902d9468041aef3542f1f
ToppCell	PND07-Immune-Immune_Myeloid-Granulocytic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADGRG3 SYNE1 CAMP GRM6 MMP9	6.11e-05	154	120	5	f92d83c5f8b532fe5624f1cd352632f543d96ea9
ToppCell	facs-Spleen-nan-24m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS57 SYNE1 CAMP MMP9 DNAH6	6.50e-05	156	120	5	034d4359359a44c205c6931f38a375271ac2752b
ToppCell	facs-Spleen-nan-24m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS57 SYNE1 CAMP MMP9 DNAH6	6.50e-05	156	120	5	2a4dac4100c0339aad4905b8eaca6e8fe806718b
ToppCell	facs-Spleen-nan-24m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS57 SYNE1 CAMP MMP9 DNAH6	6.50e-05	156	120	5	21267718d3a3dc19988663b6846aed8bb3eae836
ToppCell	facs-Spleen-nan-3m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKS6 CAMP SLC6A2 CD300LD MMP9	6.50e-05	156	120	5	f532ef4e92ac7661b1a8a4f2e98d80ce8d4e3655
ToppCell	facs-Spleen-nan-3m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKS6 CAMP SLC6A2 CD300LD MMP9	6.50e-05	156	120	5	da4f35353a84d919e683554932f110e29568df33
ToppCell	facs-Spleen-nan-3m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKS6 CAMP SLC6A2 CD300LD MMP9	6.50e-05	156	120	5	f1e25ff85c5f2f8555f9fb5ae5daed7ddb418fd1
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-CD45\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP8B1 TBC1D9 TBC1D8 CD300LD MMP9	6.90e-05	158	120	5	e0b862e4b9ebaa12869640b5d18d5fa852861bef
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CYP8B1 NRP2 TGFBR2 CHSY3 EGFL7	7.54e-05	161	120	5	fb59d96c2aa9e4654f02bf6ce36bf832776cb4dd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CYP8B1 NRP2 TGFBR2 CHSY3 EGFL7	7.54e-05	161	120	5	c53c461fc721a7960cef86662f49e2a495520701
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CYP8B1 NRP2 TGFBR2 CHSY3 EGFL7	7.77e-05	162	120	5	2ac02523348660e514d464f8f2434ee0c312d784
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	FKBP6 ADH1A SLC52A3 HPX	7.87e-05	84	120	4	39196f7af1a3199ca611acbe7b2e7a76d79c8fdd
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)\|Thalamus / BrainAtlas - Mouse McCarroll V32	FKBP6 ADH1A SLC52A3 HPX	7.87e-05	84	120	4	79cdb04e91aa119a128f0fef7a09b59a0edf00a0
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)--\|Thalamus / BrainAtlas - Mouse McCarroll V32	FKBP6 ADH1A SLC52A3 HPX	7.87e-05	84	120	4	66fc8327fc9c0f9a135e874ad2056ca414cd5148
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO19 LRRC10B LCTL ROBO3 MMP9	7.99e-05	163	120	5	7a04192710f55acf5a4681d5f09942358fdb02ff
ToppCell	E12.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADGRG3 NRP2 CSF1R EGFL7 MMP9	7.99e-05	163	120	5	c21114826bee1b05b411984326fef6b6e0d05316
ToppCell	droplet-Spleen-nan-18m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 SYNE1 CAMP CFTR MMP9	7.99e-05	163	120	5	bc37c5d9f48b16096d5313657563f3ec84028c8c
ToppCell	E12.5-Endothelial-lymphatic_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADGRG3 NRP2 CSF1R EGFL7 MMP9	7.99e-05	163	120	5	5d49414432db259a19df50d7944581d00b69f537
ToppCell	BAL-Mild-cDC_11\|Mild / Compartment, Disease Groups and Clusters	FZD3 CAMP ECE1 SLC26A1 SLC24A4	8.23e-05	164	120	5	4bd9629d054545d1e3f9e5c127b5ac2388637106
ToppCell	droplet-Spleen-nan-24m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 PRSS57 SYNE1 CAMP MMP9	8.47e-05	165	120	5	3cdb921f5b9facf04f81995d5641ac14ef3dbb6f
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO19 LRRC10B LCTL ROBO3 MMP9	8.96e-05	167	120	5	528493896aebe7d03d4b6ad2341b12927859e2e4
ToppCell	COVID-19-kidney-Lymphatic_EC\|kidney / Disease (COVID-19 only), tissue and cell type	SLC9A9 ADGRG3 NRP2 TGFBR2 CHSY3	8.96e-05	167	120	5	97d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO19 LRRC10B LCTL ROBO3 MMP9	8.96e-05	167	120	5	a82e85caf79395baa48380786d9df32a86dfd1ce
ToppCell	droplet-Spleen-nan-21m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 PRSS57 SYNE1 CAMP MMP9	8.96e-05	167	120	5	cfcd72292c733cdb18c92fdb61b68f6806d22c8c
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE1 CAMP CD300LD CSF1R MMP9	9.22e-05	168	120	5	3611605114f6b668b44728d6563cd02389e106af
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIN2A ECE1 ADH1A TAOK2 EGFL7	9.22e-05	168	120	5	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIN2A ECE1 ADH1A TAOK2 EGFL7	9.22e-05	168	120	5	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADGRG3 ECE1 NRP2 EGFL7 ROBO3	9.48e-05	169	120	5	f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCell	facs-Marrow-Granulocytes-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE1 CAMP CD300LD CSF1R MMP9	9.48e-05	169	120	5	ee1969755180df58d32904e2bb4192da9373d03e
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CWH43 CYP8B1 ECE1 TBC1D9 CHSY3	9.48e-05	169	120	5	b2d53159e344fad6fcdc485d5b8f6cf1bf094b1f
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 SYNE1 CAMP TBC1D8 MMP9	9.48e-05	169	120	5	1000eaf5158596b4898bedcc802b31db76b05a48
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 SYNE1 CAMP TBC1D8 MMP9	9.48e-05	169	120	5	83b854fa8fd9017df8f9207d9ced260eee98e8c1
ToppCell	10x5'-Lung-Lymphocytic_B_plasma\|Lung / Manually curated celltypes from each tissue	CCNI2 SAMD12 IGKV2D-40 IGKV2D-29 IGKV2-40	1.03e-04	172	120	5	8156fb6de66a4c92ade703b71c2e9187291e50ef
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKS6 CAMP CD300LD CSF1R ANO6	1.03e-04	172	120	5	574ebdf36e45222bcd907cd2c2ee7ff50ed4573a
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECE1 NRP2 SLC6A2 HPX EGFL7	1.03e-04	172	120	5	fc092a0631555d79e00ef9890cbd806e15bca2d4
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECE1 NRP2 SLC6A2 HPX EGFL7	1.03e-04	172	120	5	745725bd10c82017d678463b8fef0d2dcf09a8fd
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKS6 CAMP CD300LD CSF1R ANO6	1.03e-04	172	120	5	1627fa7035b0e0bbc82a1c0f000d8231254c680a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 FZD9 TGFBR2 CHSY3 EGFL7	1.06e-04	173	120	5	afa6bb19df52541d8d17cbfac9cbdd18a5f3632d
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS57 SAMD12 PHGDH FZD9 ROBO3	1.06e-04	173	120	5	5d7c53c6d1cdd385e44b79b82faec901747d1736
ToppCell	droplet-Lung-nan-21m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS57 CYP8B1 ECE1 TBC1D9 TBC1D8	1.09e-04	174	120	5	2afa5eea54b67c549c5058ece98296eee3829c11
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRG3 KIF26A RHCE NRP2 EGFL7	1.12e-04	175	120	5	43be63976da5ad0764d24d90919a77ce46068f52
ToppCell	10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-MPP_myeloid\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PRSS57 LRRC10B GRM6 EGFL7 ROBO3	1.12e-04	175	120	5	df369b96a780272ed52e23c8627fc63c22efa445
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)\|Thalamus / BrainAtlas - Mouse McCarroll V32	ABCA4 SPACA1 SLC22A2 MMP19	1.12e-04	92	120	4	bbaf5a131f860198840e34843b7c841bcc98d9c4
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	ABCA4 SPACA1 SLC22A2 MMP19	1.12e-04	92	120	4	e6aa2b8ca9235a7291ee41d976b886fec185835d
ToppCell	Caecum-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	SLC9A9 CAMP SAMD12 CLCN4 SLC24A4	1.15e-04	176	120	5	07cde50e1c18fcc2c5028efe1a087db4ef4d4783
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRG3 ABCA4 HYAL1 NRP2 EGFL7	1.15e-04	176	120	5	5d3b2395bb842eea39175f5af6a4c76527e2fc31
ToppCell	PBMC-Mild-cDC_11\|Mild / Compartment, Disease Groups and Clusters	FZD3 SAMD12 ECE1 CLCN4 SLC24A4	1.18e-04	177	120	5	974305e4c0eff90134c4e58cf11b955d1eee0501
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HYAL1 RHCE NRP2 EGFL7 ALPG	1.18e-04	177	120	5	d6596a0b6fd146fefc27717c1a7dbaa3774cc644
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECE1 NRP2 SLC6A2 HPX EGFL7	1.18e-04	177	120	5	6f6cf93893daac6ae228df36219ee3acf8de8f97
ToppCell	facs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ECE1 NRP2 SLC52A3 SLC6A2 EGFL7	1.21e-04	178	120	5	ebfae386a518ea33911ba3ff40464c94d18ef695
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA4 SLC6A2 FZD9 EGFL7 ROBO3	1.21e-04	178	120	5	4b3ea0921bc598ebb9f63780ecdf8ad4349f3666
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-4\|TCGA-Breast / Sample_Type by Project: Shred V9	ANKS6 LBR SLC6A2 FZD9 CLCN4	1.21e-04	178	120	5	44b5ba4e8788d3973749a1717e427647ac4c8579
ToppCell	facs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ECE1 NRP2 SLC52A3 SLC6A2 EGFL7	1.21e-04	178	120	5	ccd37575b60102f5e647c01546e8ff8fec638bd7
ToppCell	facs-Lung-18m-Endothelial-venous_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ECE1 NRP2 SLC52A3 SLC6A2 EGFL7	1.21e-04	178	120	5	87b04753650e45f12299c8456fb980d6c0d5961c
ToppCell	COVID-19-Heart-Lymph_EC\|Heart / Disease (COVID-19 only), tissue and cell type	ADGRG3 CYP8B1 NRP2 FZD9 IGKV2D-40	1.24e-04	179	120	5	411620201a860716a8773b92f50f7b94ef34a586
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages\|lymph-node_spleen / Manually curated celltypes from each tissue	NRP2 TBC1D8 CSF1R MMP9 MMP19	1.27e-04	180	120	5	7be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCell	facs-Spleen-nan-3m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LBR ADH1A EEF2 CSF1R HPX	1.27e-04	180	120	5	c0c3144011856d005aebd5cdc79f89fee32083a8
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 HTR2B ECE1 SLC52A3 EGFL7	1.31e-04	181	120	5	cef034030e6b029a49ae56be37ea1fac1a5c350e
ToppCell	TCGA-Prostate-Solid_Tissue_Normal-Prostate_normal_tissue-Prostate_normal_tissue-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	OR5AC1 OR5G3 FOXR2 OR5AC2	1.32e-04	96	120	4	7a1ff1fa9281c974b26936698b0c2a69a1001558
ToppCell	3'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA4 HYAL1 FZD9 GJD3 EGFL7	1.34e-04	182	120	5	82d6f72649c7dd4d64a84a9795edebdef2f285d6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A9 NRP2 TGFBR2 CHSY3 EGFL7	1.34e-04	182	120	5	41b070085edba7a58b81c20aa4942d06f745acf8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A9 NRP2 TGFBR2 CHSY3 EGFL7	1.34e-04	182	120	5	5e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A9 NRP2 TGFBR2 CHSY3 EGFL7	1.34e-04	182	120	5	b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-hematologic\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PRSS57 KIF26A RHCE RHD EGFL7	1.38e-04	183	120	5	1db466cf757813322db1cdcc0bf1d91c062fd9de
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRG3 RHCE NRP2 FZD9 EGFL7	1.38e-04	183	120	5	a90ffd9c50caa65f537a2e441e37655e1b622327
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRG3 RHCE NRP2 FZD9 EGFL7	1.38e-04	183	120	5	13ad20ec140ef5b96fdace3369b5befc0f40bb76
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADGRG3 ABCA4 CYP8B1 EGFL7 ROBO3	1.38e-04	183	120	5	bc98df870de65aff6dab295c24cbc199c7f2aa15
Drug	hydride	SLC9A9 CYP2D7 HTR2B CYP8B1 SYNE1 CFTR GRIN2A AQP8 LBR PHGDH PPOX ADH1A SLC6A2 CLCN4 TM7SF2 CYP4F12	4.17e-06	835	114	16	CID000000783
Drug	duloxetine	CYP2D7 HTR2B ADH1A SLC6A2 CSF1R	4.61e-06	49	114	5	CID000060834
Drug	nylidrin	GRIN2A RHCE EPHA1	1.43e-05	10	114	3	CID000004567
Drug	milnacipran	CYP2D7 HTR2B SLC6A2 CSF1R	1.48e-05	30	114	4	CID000055480
Drug	3,4-methylenedioxyamphetamine	CYP2D7 HTR2B SLC6A2 EPHA1	1.48e-05	30	114	4	CID000001614
Drug	AC1L9LF4	FKBP6 PHGDH SLC6A2 EEF2 CSF1R	1.74e-05	64	114	5	CID000447945
Drug	20,25-diazacholesterol	CYP8B1 LBR TM7SF2	1.96e-05	11	114	3	CID000009402
Disease	nephrotic syndrome type 20 (implicated_via_orthology)	TBC1D8B TBC1D9 TBC1D8	2.01e-07	4	110	3	DOID:0070357 (implicated_via_orthology)
Disease	Anemia, Hemolytic, Congenital	RHCE RHD	1.38e-05	2	110	2	C0002881
Disease	Rh Deficiency Syndrome	RHCE RHD	4.12e-05	3	110	2	C0272052
Disease	blood pressure, response to thiazide, response to beta blocker	OR5H14 OR5H1	4.12e-05	3	110	2	EFO_0004325, EFO_0007766, EFO_0007981
Disease	Rh-Null, Regulator Type	RHCE RHD	4.12e-05	3	110	2	C1849387
Disease	Malignant neoplasm of breast	KDM3A ABCA4 SYNE1 SREBF2 AQP8 GRM6 PHGDH RHD CHRND EEF2 LMF2 CSF1R SPATA21 MMP9	4.69e-05	1074	110	14	C0006142
Disease	kidney disease (biomarker_via_orthology)	SREBF2 TGFBR2 MMP9	6.38e-05	21	110	3	DOID:557 (biomarker_via_orthology)
Disease	lifestyle measurement, alcohol consumption measurement	SLC9A9 FZD3 CYP8B1 PGAP4 FZD9	7.28e-05	115	110	5	EFO_0007878, EFO_0010724
Disease	blood pressure	SLC9A9 SYNE1 TGFBR2	7.37e-05	22	110	3	EFO_0004325
Disease	lifestyle measurement, anxiety disorder measurement	SLC9A9 FZD3 CYP8B1 PGAP4 FZD9	1.66e-04	137	110	5	EFO_0007795, EFO_0010724
Disease	autism spectrum disorder (implicated_via_orthology)	SLC9A9 HTR2B NRP2 TAOK2 SLC6A2	2.69e-04	152	110	5	DOID:0060041 (implicated_via_orthology)
Disease	Aortic Aneurysm, Thoracic	TGFBR2 MMP9	2.86e-04	7	110	2	C0162872
Disease	Aortic Aneurysm, Thoracoabdominal	TGFBR2 MMP9	2.86e-04	7	110	2	C0340630
Disease	Morphine Abuse	GRIN2A MMP9	2.86e-04	7	110	2	C0600272
Disease	Aortic Aneurysm	TGFBR2 MMP9	2.86e-04	7	110	2	C0003486
Disease	Morphine Dependence	GRIN2A MMP9	2.86e-04	7	110	2	C0026552
Disease	Bone neoplasms	TGFBR2 MMP9	3.80e-04	8	110	2	C0005967
Disease	Malignant Bone Neoplasm	TGFBR2 MMP9	3.80e-04	8	110	2	C0279530
Disease	cognitive disorder (biomarker_via_orthology)	GRIN2A MMP9	3.80e-04	8	110	2	DOID:1561 (biomarker_via_orthology)
Disease	Williams-Beuren syndrome (is_implicated_in)	FKBP6 FZD3	4.87e-04	9	110	2	DOID:1928 (is_implicated_in)
Disease	Marfan Syndrome, Type I	TGFBR2 MMP9	4.87e-04	9	110	2	C4721845
Disease	response to tamoxifen	CYP2D7 SREBF2	4.87e-04	9	110	2	EFO_0009391
Disease	Colorectal Neoplasms	ABCA4 SYNE1 CFTR GRIN2A PPOX EPHA1	6.14e-04	277	110	6	C0009404
Disease	hyperhomocysteinemia (implicated_via_orthology)	GRIN2A ECE1	7.41e-04	11	110	2	DOID:9279 (implicated_via_orthology)
Disease	Marfan Syndrome	TGFBR2 MMP9	7.41e-04	11	110	2	C0024796
Disease	renal fibrosis (biomarker_via_orthology)	ECE1 MMP9	8.87e-04	12	110	2	DOID:0050855 (biomarker_via_orthology)
Disease	cholangiocarcinoma (biomarker_via_orthology)	TGFBR2 MMP9	1.05e-03	13	110	2	DOID:4947 (biomarker_via_orthology)
Disease	waist circumference	CFTR MRPL30 TBC1D9 TAOK2 SLC24A4 SLC22A2 DNAH5	1.15e-03	429	110	7	EFO_0004342
Disease	Neoplasm Metastasis	SREBF2 TGFBR2 EEF2 CSF1R MMP9	1.34e-03	217	110	5	C0027627
Disease	relapsing-remitting multiple sclerosis (is_marker_for)	MMP9 MMP19	1.40e-03	15	110	2	DOID:2378 (is_marker_for)
Disease	lung small cell carcinoma (is_marker_for)	EEF2 CSF1R	1.60e-03	16	110	2	DOID:5409 (is_marker_for)
Disease	Pulmonary Emphysema	TGFBR2 MMP9	1.81e-03	17	110	2	C0034067
Disease	extrahepatic cholestasis (biomarker_via_orthology)	CYP8B1 SLC22A2	1.81e-03	17	110	2	DOID:13619 (biomarker_via_orthology)
Disease	chronic kidney disease	ABCA4 MYO19 GRIN2A SLC24A4 SLC22A2	1.91e-03	235	110	5	EFO_0003884
Disease	inflammatory bowel disease (is_implicated_in)	ANO6 ALPI	2.26e-03	19	110	2	DOID:0050589 (is_implicated_in)
Disease	IGF-1 measurement	CRADD SREBF2 DGKB ADH1A FZD9 SLC24A4 SLC22A2	2.39e-03	488	110	7	EFO_0004627
Disease	polymyositis	SLC26A1 HCP5	2.50e-03	20	110	2	EFO_0003063
Disease	carotid artery disease (is_implicated_in)	SREBF2 MMP9	3.03e-03	22	110	2	DOID:3407 (is_implicated_in)
Disease	Bronchiectasis	CFTR DNAH5	3.03e-03	22	110	2	C0006267
Disease	Alcoholic Intoxication, Chronic	CFTR GRIN2A ADH1A SLC6A2 MMP9	3.36e-03	268	110	5	C0001973
Disease	pulmonary hypertension (biomarker_via_orthology)	HYAL1 TGFBR2 MMP9	3.36e-03	80	110	3	DOID:6432 (biomarker_via_orthology)
Disease	Mammary Neoplasms	SYNE1 SREBF2 PHGDH TGFBR2 EEF2 CSF1R MMP9	3.65e-03	527	110	7	C1458155

Protein segments in the cluster

Peptide	Gene	Start	Entry
MERRWPLGLGLVLLL	EPHA1	1	P21709
GNISVLRLPPDMVWL	CHRND	96	Q07001
WAALLILMVIIPTIG	HTR2B	56	P41595
EVLLMWLLVLAVGGT	EGFL7	6	Q9UHF1
VWIAPLQVALLMGLI	CFTR	201	P13569
LLLSMLGTVLWVNRP	CD300LD	176	Q6UXZ3
LLWVTRPLMQNGGPE	ABCA4	296	P78363
PMLLLTGRTWKGAIL	ADH1A	306	P07327
ELWRMVRIGGQPLGF	CASTOR1	261	Q8WTX7
IITLELERLMPGWCA	CCNI2	311	Q6ZMN8
KLSLVGWGLPALMVI	ADGRG3	381	Q86Y34
LIGGLNLVMLLPYWV	AQP8	101	O94778
WVVMLLIGLLAGTLA	CLCN4	71	P51793
GNALGSLEPLRWMLR	ACTR5	81	Q9H9F9
GELEWLMSLLGINPT	CALML6	56	Q8TD86
MQPEEGTGWLLELLS	TNK2	1	Q07912
LVGLGVPWGLQTMVV	SLC24A4	531	Q8NFF2
PGLIGWVVINLVMLL	LBR	391	Q14739
LITIMGNLGLIAVIW	OR5H15	36	A6NDH6
QLLGLLMLWIPGSSA	IGKV2D-29	6	A0A075B6S2
IQEVLLPWIMNLIGR	ANO6	621	Q4KMQ2
MSLWQPLVLVLLVLG	MMP9	1	P14780
PKMLGIFWINLRGII	OR52E2	81	Q8NGJ4
LITIMGNLGLIAVIW	OR5H14	36	A6NHG9
DRLLLMGTPILRDSW	ESPNL	256	Q6ZVH7
QLLGLLMLWVPGSSE	IGKV2D-40	6	P01614
LMWTTNLEPLGALLE	PRAMEF17	331	Q5VTA0
VLWEALRKMGLRPGV	MAGED1	581	Q9Y5V3
IRLWPLGLVLANTAM	MYO19	861	Q96H55
LLVLRRWQEMPGFGI	FER1L4	1426	A9Z1Z3
LITGAVLGWLMTPRV	G6PC3	176	Q9BUM1
WMLLLVPRLGAARKG	LCTL	11	Q6UWM7
LWLGFLLPMTVSGRV	MMP19	6	Q99542
ERWSPAGIGMRLEVL	NRP2	576	O60462
IIRTEGLWRPMRGLN	SLC25A28	121	Q96A46
LPAELPRMTGLRGLW	LRRC10B	151	A6NIK2
AETQGRLMLEPGRWL	KIF26A	1806	Q9ULI4
RILEWVGVGMLLGPL	PGAP4	261	Q9BRR3
VGVGMLLGPLLTWIY	PGAP4	266	Q9BRR3
SWLGGLMAIIPTITL	OR2AP1	146	Q8NGE2
PLRLGGWTILLTLTM	HCP5	36	Q6MZN7
LITIMGNLGLIAVIW	OR5H1	36	A6NKK0
PGLIGWVLINLALLM	TM7SF2	196	O76062
LITLVGNLGLMALIW	OR5AC1	36	P0C628
MVGNLGLIVLIWNDP	OR5AC2	41	Q9NZP5
MQGPWVLLLLGLRLQ	ALPI	1	P09923
LIWTLLKQVRPGMDL	OSBPL8	406	Q9BZF1
MQGPWVLLLLGLRLQ	ALPG	1	P10696
LGEDITLWGMELGLL	FKBP6	86	O75344
MAVAPLRGALLLWQL	FZD9	1	O00144
MGPGVLLLLLVATAW	CSF1R	1	P07333
GILVTQGRRWPLMID	DNAH6	3066	Q9C0G6
WLLLGALMTLGPSVV	HEATR5B	556	Q9P2D3
SLQVVGMIAWLGARP	GRM6	706	O15303
MVLTLGESWPVLVGR	KDM3A	1	Q9Y4C1
GALMERLGVLWTLLV	GRTP1	216	Q5TC63
MRAEGGLWLRVEPLN	CYP4F12	506	Q9HCS2
RLGPEWEPMVLSLGL	CRADD	126	P78560
AVMLLLLLPWTAQGR	IL23A	6	Q9NPF7
LEEWIQGGMTTIPLL	DGKB	216	Q9Y6T7
RAIGNIIPLQTLWMA	MTFMT	266	Q96DP5
WSPLMLAALTGRLGV	ANKS6	226	Q68DC2
GRWSLVLLLLGLVMP	CAMP	11	P49913
LQSPLVGRLWLVVML	GJD3	16	Q8N144
WGIPGTLTIILLAMN	FZD3	336	Q9NPG1
GQVPGLLDWDMRNEL	FOXR2	16	Q6PJQ5
QLLGLLMLWIPGSSA	IGKV2-29	6	A2NJV5
QLLGLLMLWVPGSSE	IGKV2-40	6	A0A087WW87
AWMAGTLQLGRALRP	HYAL1	181	Q12794
RRWLPAGDALLQMIT	EEF2	341	P13639
AKPLMELIERLGGWN	ECE1	196	P42892
IWLELPLMVFGVLGL	SLC22A2	491	O15244
GLLMTVGWLLLAGLQ	SPACA1	11	Q9HBV2
MVLWGPVLGALLVVI	CYP8B1	1	Q9UNU6
PAQVGLLGIQMIWTR	DNAH5	1826	Q8TE73
RPSPAQLGALRVMLW	MLNR	236	O43193
LITLGGNLGMITLIW	OR5G3	36	P0C626
GNLGMITLIWIDPRL	OR5G3	41	P0C626
MPGWRLLTQVGAQVL	MRPL3	1	P09001
MPSLWREILLESLLG	CWH43	1	Q9H720
RKGPSLWMALIVLQL	RNF139	121	Q8WU17
MARVLGAPVALGLWS	HPX	1	P02790
HMRPIGLTWVLQLTL	RTBDN	6	Q9BSG5
GLPQWQLLLCLMVVV	SLC6A2	231	P23975
LTEVIGPIWLMLLLG	PHTF2	166	Q8N3S3
NGLWVELPLLVMELP	SLC52A3	21	Q9NQ40
TPMLTWLQIRVGVDL	SLC9A9	481	Q8IVB4
VLLGPALDLGWRRME	SPATA21	166	Q7Z572
MAGILRLVVQWPPGR	MRPL30	1	Q8TCC3
DGRPSIVLGLMWTII	SYNE1	116	Q8NF91
PALLWGLLMAVGAVR	LMF2	636	Q9BU23
MPKLRVLELQGLGWE	FBXL12	281	Q9NXK8
MWKGVLRPGTALVLL	EPPK1	3316	P58107
RGWGRPLLTVATALM	PRSS57	6	Q6UWY2
MGRGLLRGLWPLHIV	TGFBR2	1	P37173
LALPLVAMAAGGRWV	TAOK2	1056	Q9UL54
TLLLPDGWMDGEIRR	SAMD12	156	Q8N8I0
VQMSSLPWRVVIGRL	MED13	1851	Q9UHV7
MAVVPLLLLGGLWSA	SDF2	1	Q99470
PMITSIPLNLWGRDL	ERVK-9	861	P63128
RRPWMSVALGLVLGF	CHSY3	6	Q70JA7
WGLLLMILHLDVQRG	CYP2D7	316	A0A087X1C5
MRGITPLLERWLGNL	PRPF8	641	Q6P2Q9
QWSLRGGLEMLPQAL	PPOX	226	P50336
EVFGKRWLLGLLVPM	ZDHHC22	236	Q8N966
RWLLGLLVPMFNVGS	ZDHHC22	241	Q8N966
NLGRMIDWVPVESLL	ZER1	181	Q7Z7L7
PWLAMVLGLVAGLIS	RHD	291	Q02161
PWLAMVLGLVAGLIS	RHCE	291	P18577
MGVSLGITLWPLLSR	SLC16A5	146	O15375
RGIPETLRGELWMLF	TBC1D8B	486	Q0IIM8
GPGMVVLTWLSLLRG	SLC26A1	241	Q9H2B4
IVRMLNRGLGNTWTP	WDHD1	646	O75717
MLGARAWLGRVLLLP	SPATA20	1	Q8TB22
WARSAMLRGLVPGLL	ROBO3	826	Q96MS0
LVAMGIPESLRGRLW	TBC1D8	501	O95759
MPTLLLWLVNGVIVL	SREBF2	536	Q12772
IPESMRGELWLLLSG	TBC1D9	516	Q6ZT07
TEGLKVWLGIMLPVL	TMEM214	271	Q6NUQ4
VWLGIMLPVLGIKSL	TMEM214	276	Q6NUQ4
LMWTTNLEPLGVLLE	PRAMEF10	331	O60809
PWIGLAEALGTLMRA	PHGDH	331	O43175
MAGNSLVLPIVLWGR	WDR7	1	Q9Y4E6
MWLQQRLKGLPGLLS	KIAA2013	1	Q8IYS2
MGRVGYWTLLVLPAL	GRIN2A	1	Q12879