Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainGAF

EFCAB5 PDE6C PDE6B

1.31e-0581173IPR003018
DomainGAF

EFCAB5 PDE6C PDE6B

1.31e-0581173SM00065
Domain-

EFCAB5 PDE6C PDE6B

1.96e-05911733.30.450.40
DomainGAF_dom-like

EFCAB5 PDE6C PDE6B

1.96e-0591173IPR029016
DomainPecanex_C

PCNX3 PCNX4

2.32e-0441172PF05041
DomainPecanex

PCNX3 PCNX4

2.32e-0441172IPR007735
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

BRIX1 ACACA POLR2A NAP1L1 SRPK1 MYO1B HUWE1 RFC1 THOC2 SERPINH1 TSR1 UTP20 PUM3 STAG2 AQR

9.34e-096531211522586326
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

BRIX1 ACACA POLR2A SPATA18 NAP1L1 MYO1B IDE HUWE1 RFC1 THOC2 SERPINH1 TSR1 NEMF KLHL23 UTP20 PUM3 UBE3C STAG2 TARS1 GOLGA4 AQR

2.13e-0814251212130948266
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

TPRA1 ACACA TMEM8B TRPS1 IDE HUWE1 TECTA CDC42BPB AFMID PLXDC2 PCNX4 NEMF KLHL23 KNDC1 LRP1 UBE3C STAG2 VPS13B GOLGA4

9.65e-0714891211928611215
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

HEXA ABCC3 TPRA1 ACACA PCNX3 TMEM8B POLR2A HUWE1 CDC42BPB ST14 FANCA PIKFYVE RPAP1 PCNX4 PLA2G4B UBE3C

1.52e-0611051211635748872
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

SRPK1 CC2D1B ZDHHC17 FANCA TMEM62 RPAP1 TSR1 CHTF18 PRKAA1 NEMF AQR SORL1

3.01e-066501211238777146
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

BRIX1 ACACA POLR2A NAP1L1 SRPK1 HUWE1 RFC1 SERPINH1 TSR1 CHTF18 PRKAA1 NEMF PARVA STAG2 TARS1 GOLGA4 AQR

8.43e-0614151211728515276
Pubmed

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.

POLR2A NAP1L1 SRPK1 MYO1B RFC1 SERPINH1 CDC42BPB TSR1 PRKAA1 NEMF PARVA

8.61e-066011211133658012
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

HEXA BRIX1 ACACA PIGS SRPK1 MYO1B RFC1 RRM2 SERPINH1 CDC42BPB TAMM41 TSR1 NEMF UBE3C POGLUT2 AQR

1.15e-0512971211633545068
Pubmed

Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation.

PDE6C PDE6B

1.20e-052121226085644
Pubmed

Association of Nod-like receptor protein-1 (rs2670660) and Toll-like receptor-4 (rs4986790) with non-segmental vitiligo: A case-control study in South Indian population.

NLRP1 TLR4

1.20e-052121231293094
Pubmed

Cone Phosphodiesterase-6γ' Subunit Augments Cone PDE6 Holoenzyme Assembly and Stability in a Mouse Model Lacking Both Rod and Cone PDE6 Catalytic Subunits.

PDE6C PDE6B

1.20e-052121230038560
Pubmed

Calcium dynamics change in degenerating cone photoreceptors.

PDE6C PDE6B

1.20e-052121227402880
Pubmed

Gpn2 and Rba50 Directly Participate in the Assembly of the Rpb3 Subcomplex in the Biogenesis of RNA Polymerase II.

RPAP1 GPN2

1.20e-052121229661922
Pubmed

Preservation of Visual Cortex Plasticity in Retinitis Pigmentosa.

PDE6B TLR4

1.20e-052121231901258
Pubmed

Systematic spatiotemporal mapping reveals divergent cell death pathways in three mouse models of hereditary retinal degeneration.

PDE6C PDE6B

1.20e-052121231710697
Pubmed

Isolation and characterization of a novel acetyl-CoA carboxylase kinase from rat liver.

ACACA PRKAA1

1.20e-05212127907095
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

BRIX1 POLR2A NAP1L1 MYO1B HUWE1 THOC2 SERPINH1 RPAP1 PRKAA1 UTP20 PUM3 STAG2 TARS1 AQR

1.37e-0510241211424711643
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

BRIX1 ACACA POLR2A NAP1L1 HUWE1 RRM2 THOC2 SERPINH1 UBE3C STAG2 TARS1

1.50e-056381211133239621
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

BRIX1 POLR2A SRPK1 HUWE1 TSR1 NEMF UTP20 PUM3

2.24e-05332121825693804
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

BRIX1 ACACA POLR2A HUWE1 RRM2 SERPINH1 CHTF18 PUM3 AQR

2.48e-05440121934244565
Pubmed

AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue.

ACACA PRKAA1

3.59e-053121234668531
Pubmed

AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.

ACACA PRKAA1

3.59e-053121230018077
Pubmed

Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium.

PDE6B PRKAA1

3.59e-053121230249643
Pubmed

AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1.

ACACA PRKAA1

3.59e-053121223785098
Pubmed

Clinical and genetic investigations of three Moroccan families with retinitis pigmentosa phenotypes.

ABCA4 PDE6B

3.59e-053121233633436
Pubmed

Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.

LRP1 SORL1

3.59e-053121228799085
Pubmed

Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration.

ABCA4 PDE6B

3.59e-053121222169101
Pubmed

Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation.

PDE6B TLR4

3.59e-053121228885615
Pubmed

AMP-activated protein kinase is involved in the activation of the Fanconi anemia/BRCA pathway in response to DNA interstrand crosslinks.

FANCA PRKAA1

3.59e-053121227449087
Pubmed

Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase.

ACACA PRKAA1

3.59e-05312122900138
Pubmed

Phosphatidylinositol 4-phosphate 5-kinase α facilitates Toll-like receptor 4-mediated microglial inflammation through regulation of the Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location.

PIKFYVE TLR4

3.59e-053121223297396
Pubmed

A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-8.

TNFAIP8L2 TLR4

3.59e-053121224934366
Pubmed

The significance of heat-shock protein gp96 and its receptors' CD91 and Toll-like receptor 4 expression at the maternal foetal interface.

TLR4 LRP1

3.59e-053121223755898
Pubmed

Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner.

PIKFYVE PRKAA1

3.59e-053121234107300
Pubmed

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.

ACACA PRKAA1

3.59e-053121227381369
Pubmed

TRIM65 regulates microRNA activity by ubiquitination of TNRC6.

BRIX1 POLR2A SRPK1 IDE TSR1 NEMF TARS1 SORL1

4.29e-05364121824778252
Pubmed

Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice.

PDE6C PDE6B

7.17e-054121231825309
Pubmed

Quantification of Oxygen Consumption in Retina Ex Vivo Demonstrates Limited Reserve Capacity of Photoreceptor Mitochondria.

RPGRIP1 PDE6B

7.17e-054121226747773
Pubmed

CC2D1A and CC2D1B regulate degradation and signaling of EGFR and TLR4.

CC2D1B TLR4

7.17e-054121227769858
Pubmed

Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase.

ACACA PRKAA1

7.17e-054121218040027
Pubmed

Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD.

IDE PRKAA1

7.17e-054121229222348
Pubmed

Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise.

ACACA PRKAA1

7.17e-054121223000302
Pubmed

Human CTF18-RFC clamp-loader complexed with non-synthesising DNA polymerase ε efficiently loads the PCNA sliding clamp.

RFC1 CHTF18

7.17e-054121228199690
Pubmed

Acute exercise does not cause sustained elevations in AMPK signaling or expression.

ACACA PRKAA1

7.17e-054121218614941
Pubmed

Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.

PDE6C PDE6B

7.17e-054121223033484
Pubmed

Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation.

POLR2A SRPK1

7.17e-054121228076779
Pubmed

Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal.

ABCA4 TLR4

7.17e-054121223572532
Pubmed

Rod phosphodiesterase-6 (PDE6) catalytic subunits restore cone function in a mouse model lacking cone PDE6 catalytic subunit.

PDE6C PDE6B

7.17e-054121221799013
Pubmed

A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity.

RFC1 CHTF18

7.17e-054121217545166
Pubmed

Kidney bean husk extracts exert antitumor effect by inducing apoptosis involving AMP-activated protein kinase signaling pathway.

ACACA PRKAA1

7.17e-054121219723093
Pubmed

AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation.

ACACA PRKAA1

7.17e-054121211052978
Pubmed

The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain.

LRP1 SORL1

7.17e-054121223283348
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

ACACA POLR2A NAP1L1 SRPK1 MYO1B HUWE1 RFC1 RRM2 SERPINH1 CHTF18 UTP20 PUM3 TARS1 GOLGA4 AQR

7.43e-0513531211529467282
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

ACACA NAP1L1 SRPK1 MYO1B CDC42BPB UTP20

7.87e-05202121633005030
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ACACA POLR2A HUWE1 RFC1 THOC2 RPAP1 CHTF18 MSL3 UTP20 STAG2 GOLGA4

8.58e-057741211115302935
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

BRIX1 POLR2A HUWE1 RFC1 THOC2 SERPINH1 TSR1 MSL3 PUM3 MPHOSPH9

8.98e-056451211025281560
Pubmed

Discovery and refinement of loci associated with lipid levels.

TTC39B PCNX3 TRPS1 RFC1 LRP1 ABCG5

9.99e-05211121624097068
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

CLGN PIGS NAP1L1 HUWE1 ZDHHC17 SERPINH1 FANCA RPAP1 NUS1 UTP20 STAG2 TARS1

1.14e-049421211231073040
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

ACACA POLR2A SRPK1 MYO1B UPF3A HUWE1 RFC1 THOC2 SERPINH1 TSR1 CHTF18 NEMF TARS1 AQR

1.15e-0412471211427684187
Pubmed

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.

HUWE1 PRKAA1

1.19e-045121233004795
Pubmed

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma.

NLRP1 TLR4

1.19e-045121225024200
Pubmed

Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes.

PRKAA1 TLR4

1.19e-045121226232429
Pubmed

Activity-Based Probes for HECT E3 Ubiquitin Ligases.

HUWE1 UBE3C

1.19e-045121228425671
Pubmed

Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue.

ACACA PRKAA1

1.19e-045121218480843
Pubmed

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.

LRP1 SORL1

1.19e-045121219047013
Pubmed

Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family.

LRP1 SORL1

1.19e-045121217326667
Pubmed

Fanconi Anemia Mesenchymal Stromal Cells-Derived Glycerophospholipids Skew Hematopoietic Stem Cell Differentiation Through Toll-Like Receptor Signaling.

FANCA TLR4

1.19e-045121226212365
Pubmed

Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum.

KCNB2 KNDC1 CADPS2

1.56e-0430121318603407
Pubmed

A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.

CCNO RFC1 CHTF18

1.72e-0431121312171929
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

EFCAB5 SRPK1 MYO1B RFC1 THOC2 VPS13B

1.76e-04234121636243803
Pubmed

Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit.

PDE6C PDE6B

1.78e-046121219798052
Pubmed

AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170.

ACACA PRKAA1

1.78e-046121233251722
Pubmed

Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration.

RPGRIP1 PDE6B

1.78e-046121226139610
Pubmed

A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance.

ACACA PRKAA1

1.78e-046121227524625
Pubmed

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes.

IDE LRP1

1.78e-046121222383525
Pubmed

A mouse model for studying cone photoreceptor pathologies.

PDE6C PDE6B

1.78e-046121225034607
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

BRIX1 ACACA POLR2A NAP1L1 MYO1B HUWE1 RFC1 THOC2 SERPINH1 TSR1 UTP20 PUM3

1.79e-049891211236424410
Pubmed

The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.

ACACA HUWE1 TARS1

2.08e-0433121326296893
Pubmed

Mieap forms membrane-less organelles involved in cardiolipin metabolism.

SPATA18 TAMM41

2.49e-047121238322995
Pubmed

Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mapping.

PTPRD PRKAA1

2.49e-047121217619104
Pubmed

A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex.

POLR2A HUWE1

2.49e-047121231980388
Pubmed

Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration.

PDE6C PDE6B

2.49e-047121225392995
Pubmed

The interplay of UBE2T and Mule in regulating Wnt/β-catenin activation to promote hepatocellular carcinoma progression.

HUWE1 FANCA

2.49e-047121233542213
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

ACACA POLR2A FAM227B HUWE1 ITGAE FANCA ZFYVE28 RPAP1 UTP20 SLC26A11

2.60e-047361211029676528
Pubmed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

BRIX1 CLGN ACACA NAP1L1 SRPK1 SERPINH1 PRKAA1 TARS1

3.03e-04484121831995728
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

NAP1L1 HUWE1 RFC1 THOC2 TSR1 CHTF18 NEMF UBE3C

3.11e-04486121830940648
Pubmed

Npa3 interacts with Gpn3 and assembly factor Rba50 for RNA polymerase II biogenesis.

RPAP1 GPN2

3.32e-048121232985767
Pubmed

The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations.

ACACA PRKAA1

3.32e-048121236001969
Pubmed

Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c.

MYO1B PARVA

3.32e-048121212490950
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

BRIX1 SRPK1 RFC1 THOC2 TSR1 NEMF UTP20 PUM3 UBE3C AQR

3.32e-047591211035915203
Pubmed

Requirement of the Mowat-Wilson Syndrome Gene Zeb2 in the Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.

ABCA4 PDE6C PDE6B

3.43e-0439121329922981
Pubmed

Mouse model resources for vision research.

RPGRIP1 PDE6C PDE6B

3.98e-0441121321052544
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

HUWE1 ZDHHC17 THOC2 CNOT8 AFMID TSR1 PRKAA1 TLR4 POGLUT2 STAG2 VPS13B NCKAP1L

4.10e-0410841211211544199
Pubmed

Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7.

HUWE1 UBE3C

4.25e-04912129575161
Pubmed

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.

LRP1 SORL1

4.25e-049121220005821
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

BRIX1 PIGN NAP1L1 SRPK1 MYO1B RFC1 THOC2 SERPINH1 TSR1 UTP20 PUM3 TARS1 AQR

4.47e-0412571211336526897
Pubmed

Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment.

RFC1 CHTF18

5.30e-0410121212766176
Pubmed

SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase.

ACACA PRKAA1

5.30e-0410121219720090
Pubmed

Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.

ABCC3 AANAT ABCA4 ALDH3B1 ABCG5

5.90e-04193121519343046
Pubmed

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

TTC39B NAP1L1 SRPK1 HUWE1 RFC1 RRM2 SERPINH1 TSR1 LRP1 AQR NCKAP1L

5.95e-049711211133306668
CytobandEnsembl 112 genes in cytogenetic band chr5p13

BRIX1 PRKAA1 PLCXD3 TARS1

5.20e-041391214chr5p13
Cytoband12q21.2

NAP1L1 ZDHHC17

1.27e-0320121212q21.2
CytobandEnsembl 112 genes in cytogenetic band chr17p13

POLR2A NLRP1 ITGAE OR1D2 TSR1

2.30e-033461215chr17p13
Cytoband5p13.2

BRIX1 TARS1

3.05e-033112125p13.2
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

RPGRIP1 CC2D1B CADPS2

3.78e-0436713823
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ACACA SRPK1 PTPRD SCTR PUM3 CADPS2 FAM20A

7.82e-071861217acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCellwk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RAD9B PTPRD HECTD2 DCHS1 LRP1 VPS13B

6.24e-06166121665dafed953b01a9830b54309af75c7a561e88336
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-skeletal_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASQ1 HHATL PPP1R3A SMTNL1 TMEM232 SCTR

8.16e-0617412164a6e04b4f12b87c15fa1409989cbe32c43736369
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-skeletal_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASQ1 CRAT HHATL PPP1R3A SMTNL1 SCTR

9.29e-06178121669f68eeab11b088fcb1f963c92eff0f1cd0e711a
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNB2 PTPRD OTOGL SCTR PLCXD3 CADPS2

9.59e-0617912168766a5a066091879f521acfc612abf563ff78808
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPS1 MYO1B TOP6BL CDC42BPB SLC16A4 FAM20A

1.16e-051851216a0a629e5d2b65f670ea907bd3f5e3caf17687d8f
ToppCelldroplet-Limb_Muscle-nan-24m-Mesenchymal-skeletal_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASQ1 CRAT HHATL PPP1R3A SMTNL1 SCTR

1.16e-0518512169245c322aae8bb9065d50dada198a5ee143a3444
ToppCellChildren_(3_yrs)-Immune-monocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRPS1 NLRP1 PLXDC2 PLXNC1 SORL1 NCKAP1L

1.47e-05193121658e1930a1d80ad3729ab9604ac8ebf7308232a3d
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

HUWE1 THOC2 LRRC8B STAG2 VPS13B AQR

1.47e-051931216abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellwk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ANKUB1 SPATA18 CFAP65 TMEM232 KNDC1 ALDH3B1

1.51e-051941216756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCell10x5'-lymph-node_spleen-Myeloid_Monocytic-Nonclassical_monocytes|lymph-node_spleen / Manually curated celltypes from each tissue

ABCC3 PLXDC2 TLR4 LRP1 ALDH3B1 FAM20A

1.65e-05197121667f19dd30adb03300f04219d0295bc1c1788f626
ToppCellBAL-Control-cDC_0|Control / Compartment, Disease Groups and Clusters

HEXA ABCC3 PLXDC2 TLR4 LRP1 SORL1

1.75e-0519912164518ffa51ead9da1ddf07bf048b18602e50f0f84
ToppCellcellseq2-Immune-Immune_Myeloid-IM-IM|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TNFAIP8L2 PLXDC2 PLXNC1 TLR4 LRP1 NCKAP1L

1.75e-051991216372fb9eb90022dc4ac770a75b4e207c33d1d0c43
ToppCellcellseq2-Immune-Immune_Myeloid-IM|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TNFAIP8L2 PLXDC2 PLXNC1 TLR4 LRP1 NCKAP1L

1.75e-051991216dd3bf59cdc18091889cbf6c43f37100ba537843d
ToppCellcellseq2-Immune-Immune_Myeloid|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TNFAIP8L2 PLXDC2 PLXNC1 TLR4 LRP1 NCKAP1L

1.75e-0519912166c3c9eceea20121ae17ae2462134aa0437f591b3
ToppCellCOVID-19-COVID-19_Convalescent-Myeloid-CD16+_Monocyte|COVID-19_Convalescent / Disease, condition lineage and cell class

ABCC3 PLXNC1 TLR4 KNDC1 ALDH3B1 FAM20A

1.80e-052001216f24abb2d54d6423ee886285e3c66a874ec59e1a3
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Klk6_(Klk6)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ANKUB1 PKD1L1 SPATA18 CASQ1

4.95e-05741214a53f2e1f1044f3745a1eff5ba6275c8f1fbf3ae0
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Klk6_(Klk6)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ANKUB1 PKD1L1 SPATA18 CASQ1

4.95e-05741214ae547cb8bbd780b19d9c6b555c27dad932dcc753
ToppCellCOVID-19-APC-like-Alveolar_macrophages|COVID-19 / group, cell type (main and fine annotations)

TPRA1 XKR8 PLA2G4B GPN2 TLR4

6.76e-051561215735ade77cfa16b9386a0c7ec2bd14bd2e78a51ad
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACA POLR2A XKR8 CHTF18 UBE3C

7.18e-0515812151d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCell10x5'-Lung-Lymphocytic_T_CD4/8-lo-Trm_Tgd|Lung / Manually curated celltypes from each tissue

PDE6B CC2D1B FAM227B ITGAE SCRN2

9.32e-051671215dcbcc658082910838c8082d71a64917055086cc4
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NAP1L1 RRM2 PTPRD PLXDC2 CHTF18

1.01e-041701215e20568c8f3f17d94de78229617eb2f7e4c5af2bc
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM8B SPATA18 CFAP65 KNDC1 ALDH3B1

1.04e-0417112151854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TTC39B PLXDC2 TLR4 LRP1 NCKAP1L

1.13e-041741215d5c22b43531414951666ee7542a66ed9380e2d14
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNB2 PTPRD OTOGL PLCXD3 CADPS2

1.13e-041741215b3cd22e717d178269e6d5bd5ed7b2d945cd8ea25
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPS1 KCNB2 OTOGL PLCXD3 CADPS2

1.13e-041741215ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.6.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HEXA TNFAIP8L2 TAMM41 LRP1 NCKAP1L

1.22e-041771215929cd8f530ce001623735da53b7278d02522e2b5
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANKUB1 HHATL CFAP65 TMEM232 KNDC1

1.29e-0417912155e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

ACACA PTPRD SCTR CADPS2 FAM20A

1.32e-041801215198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellfacs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1B PPP1R3A PTPRD PLXDC2 LRP1

1.39e-041821215c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCellP28-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NAP1L1 MYO1B PTPRD PLXDC2 LRP1

1.39e-04182121519c5e3a9d9b3728303b682102e276adfe93aa759
ToppCellfacs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1B PPP1R3A PTPRD PLXDC2 LRP1

1.39e-041821215dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NAP1L1 MYO1B PTPRD PLXDC2 LRP1

1.47e-041841215924400f47e6b2cdf7b0d538df75857935cf0209b
ToppCellPBMC-Mild-cDC_9|Mild / Compartment, Disease Groups and Clusters

PIGN CLGN TLR4 UTP20 FAM20A

1.47e-0418412152e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCellAT2_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

MYO1B CHI3L2 SLC16A4 SCTR FAM20A

1.51e-0418512153b3268e3f99121124e33086cac88479808d31630
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ANKUB1 SPATA18 CFAP65 TMEM232 KNDC1

1.51e-0418512155e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCelldroplet-Liver-Npc-18m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRPK1 ZDHHC17 PPP1R3A CLEC14A DCHS1

1.54e-04186121575258d88e23112fd1f0f7c71ef0366abb400d33e
ToppCelldroplet-Lung-nan-18m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPATA18 FAM227B SMTNL1 TMEM232 KNDC1

1.54e-041861215740fd06bcd3b24e6ff2ecf8080f378afc3e95084
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ANKUB1 SPATA18 CFAP65 TMEM232 KNDC1

1.54e-04186121585787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCelldroplet-Lung-nan-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPATA18 FAM227B SMTNL1 TMEM232 KNDC1

1.54e-0418612155ab43a298d23238b34e898d11decf0ad81d1b14e
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NAP1L1 MYO1B PTPRD PLXDC2 LRP1

1.54e-04186121588e6246172d816806a498a5c1f38e699f2f5d7c2
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1B SERPINH1 PTPRD PLXDC2 PLCXD3

1.58e-041871215976b74d081b7fba8620768613cc26f9262cd7b16
ToppCell21-Trachea-Epithelial-Multiciliated_cell|Trachea / Age, Tissue, Lineage and Cell class

ANKUB1 SPATA18 CFAP65 TMEM232 ALDH3B1

1.62e-041881215803bf76a85b3033d2a04b08dd2c03ce9c15529ba
ToppCellRA-11._Adipocyte|World / Chamber and Cluster_Paper

ACACA TRPS1 SCRN2 KANK4 LRRC8B

1.62e-0418812154dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

ACACA SCTR PUM3 CADPS2 FAM20A

1.62e-041881215ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-skeletal_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASQ1 HHATL PPP1R3A SMTNL1 SCTR

1.66e-041891215d2b008f98739c6af7ee63b643011a240db20e4d8
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRD PLXDC2 LRP1 PLCXD3 FAM20A

1.66e-041891215324c81285c51f4f8bb1aef428b18fe2c549c2c11
ToppCellfacs-Lung-nan-3m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPATA18 HHATL CFAP65 TMEM232 KNDC1

1.70e-041901215e243b5fbb17b9ec3cc90bbe970c1d30b0fd1c2e1
ToppCellfacs-Lung-nan-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPATA18 HHATL CFAP65 TMEM232 KNDC1

1.70e-041901215fe844559b95832845d2e8d3ab4b57e3d558bc372
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYO1B SERPINH1 PTPRD PLXDC2 LRP1

1.75e-041911215509230f50568e5a8ecf08edc4d58f9e2aa96efe9
ToppCellControl-Myeloid|Control / group, cell type (main and fine annotations)

TRPS1 PLXDC2 TLR4 LRP1 NCKAP1L

1.75e-0419112159c4acc5f3c2f9c0c5520863bb22f391774372347
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SERPINH1 PTPRD PLXDC2 LRP1 FAM20A

1.75e-041911215094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYO1B TOP6BL CADPS2 FAM20A SORL1

1.75e-0419112157235a4d1601c88a2c8af571a2c04ab56d32f1b9a
ToppCellfacs-Lung-24m-Mesenchymal|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SERPINH1 PTPRD PLXDC2 LRP1 FAM20A

1.75e-041911215ba02cbdfda6a94374a6472eb88499059979af472
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC39B MYO1B MSL3 STAG2 GOLGA4

1.75e-04191121509db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYO1B SERPINH1 PTPRD PLXDC2 LRP1

1.75e-0419112150b3dbbc35d9970d3c749aef16dda59886b960e3d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCNO MYO1B TOP6BL CADPS2 FAM20A

1.79e-0419212159e031bf93eb8757fdd0cc22f01b44e48f85532d5
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCNO MYO1B TOP6BL CADPS2 FAM20A

1.79e-0419212153d777d07878269b87ec7e1f06489cae7c989d633
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1B SERPINH1 PTPRD CLEC14A PARVA

1.79e-041921215be75783d9578974b662e1cb13bd3442a921fd50a
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D122|Adult / Lineage, Cell type, age group and donor

ACACA KNDC1 SCTR CADPS2 FAM20A

1.79e-04192121506013a07e3a873b1d1c0451643c528593ac32a9c
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CCNO MYO1B CADPS2 FAM20A SORL1

1.79e-041921215d5ec4cdb15620a5abfc83577353501186c2bc86a
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1B SERPINH1 PTPRD CLEC14A PARVA

1.79e-0419212154fc98f30f8e738816cd93101fbe8ac40889e302a
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERPINH1 PTPRD PLXDC2 LRP1 FAM20A

1.79e-0419212155876ff75e273a48e7ad8236423fb41e4ae4c0a91
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ACACA PTPRD SCTR CADPS2 FAM20A

1.83e-041931215fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CCNO MYO1B TOP6BL CADPS2 FAM20A

1.83e-041931215371f4c98a599923fbe8382530b3eab05d873665a
ToppCellsevere-Myeloid-Neutrophils_3|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

XKR8 SRPK1 MMP25 PLXNC1 SORL1

1.83e-041931215f4d43dfbf4115dd0f843ea5cf08049220342a047
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ACACA PTPRD SCTR CADPS2 FAM20A

1.83e-041931215f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLXDC2 PLXNC1 TLR4 LRP1 ALDH3B1

1.83e-0419312154fb020f11fd7aff06952bfeaabc79b2c7b8873f6
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CCNO MYO1B CADPS2 FAM20A SORL1

1.83e-0419312155da60321bcf761913eb30779b6d8b1e933c5e51e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TOP6BL SLC16A4 CADPS2 FAM20A SORL1

1.88e-041941215be869e186386d03ebb670971dd24fa656b4b0edf
ToppCellhealthy_donor-Myeloid-Monocytic-CD16+_Monocyte|healthy_donor / Disease condition, Lineage, Cell class and subclass

NAP1L1 PLXNC1 TLR4 KNDC1 ALDH3B1

1.88e-041941215ecf746ef1c5c4d6d9ca06a6d3e3778670b5700c2
ToppCellsevere-Myeloid-Neutrophils_3|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

XKR8 SRPK1 MMP25 PLXNC1 SORL1

1.88e-0419412151f8edab1c8ba48bc0114429ea47aab378b5830b7
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PLXDC2 PLXNC1 TLR4 LRP1 ALDH3B1

1.88e-041941215885355ebe98e974f841cc59dce3b5228c642c5d0
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CCNO MYO1B TOP6BL CADPS2 FAM20A

1.88e-041941215158dc393639e69aecfb014f6106797214ea05fe5
ToppCellPND07-28-samps-Mesenchymal|PND07-28-samps / Age Group, Lineage, Cell class and subclass

MYO1B SERPINH1 PTPRD PLXDC2 PARVA

1.88e-04194121568bcc1fe8dc8d5f23a12154fc9b41362fdef0b1d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPS1 PLXDC2 LRP1 FAM20A NCKAP1L

1.88e-04194121545708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPS1 PLXDC2 LRP1 FAM20A NCKAP1L

1.92e-041951215247803cf58c6d9c561a52aa34e581188ddad197e
ToppCellmild-Myeloid-CD16_Monocytes|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ABCC3 KNDC1 LRP1 ALDH3B1 FAM20A

1.92e-041951215e963d33b50d43e38cada738e41343b64e3d08b79
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

ACACA ANKUB1 PTPRD CADPS2 VPS13B

1.97e-041961215ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellCOVID-19_Moderate-Non-classical_Monocyte|COVID-19_Moderate / disease group, cell group and cell class

ABCC3 PLXNC1 TLR4 LRP1 ALDH3B1

1.97e-041961215256c557fa11414c9d2cbb1fcff33f482ee1c78ac
ToppCellCOVID-19-Myeloid-Monocytes|COVID-19 / group, cell type (main and fine annotations)

ANKUB1 TRPS1 PLXDC2 SORL1 NCKAP1L

1.97e-04196121504d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRPS1 NLRP1 PLXDC2 PLXNC1 NCKAP1L

1.97e-041961215cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MYO1B RRM2 SERPINH1 PARVA FAM20A

1.97e-041961215cb5860f580b477bfa52b22cdc21b808e1371e6e0
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HEXA ABCC3 PLXDC2 TLR4 LRP1

1.97e-0419612155fe6534af65d43eeacd4b031310242b4f706008b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPS1 PLXDC2 PLXNC1 LRP1 NCKAP1L

2.02e-0419712158af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCellPND01-Mesenchymal|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NAP1L1 SERPINH1 PTPRD PLXDC2 LRP1

2.02e-041971215292b8cc3dafddf5d323fe4e3d3ea5ac61e6ce027
ToppCellCOVID-19-kidney-Macrophages|COVID-19 / Disease (COVID-19 only), tissue and cell type

TRPS1 PLXDC2 PLXNC1 SORL1 NCKAP1L

2.02e-0419712153912301018d0863144dcfac8d1fa8adc081748d7
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_monocytic-monocyte|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PLXDC2 PLXNC1 TLR4 LRP1 ALDH3B1

2.02e-041971215ec46aa307ce5774b4c0fcba64514f2d0cab3c4f9
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_monocytic|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PLXDC2 PLXNC1 TLR4 LRP1 ALDH3B1

2.02e-041971215b91016249b3585aa3536e96af18e4f1b1d2d5ce4
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ABCC3 PTPRD PLXDC2 HECTD2 CADPS2

2.02e-0419712150034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCellAT2_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

MYO1B CHI3L2 SLC16A4 SCTR FAM20A

2.02e-0419712158b5d4e1c33a57c899c51feb9a6f347232f8910a3
ToppCell3'_v3-GI_small-bowel-Myeloid_Monocytic|GI_small-bowel / Manually curated celltypes from each tissue

PLXDC2 TLR4 LRP1 ALDH3B1 FAM20A

2.02e-041971215dcf0009057576a7db9065e644a3919d6de2ac8e6
ToppCellCOVID-19-Myeloid|COVID-19 / group, cell type (main and fine annotations)

ANKUB1 PLXDC2 TLR4 LRP1 NCKAP1L

2.06e-04198121533f0a919188a67d2a876b52c61a1cec2c9747969
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ACACA PTPRD SCTR CADPS2 FAM20A

2.06e-0419812152e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCellFibroblasts-HLA-DRA_high_Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

MYO1B CHI3L2 SERPINH1 PARVA FAM20A

2.06e-041981215e8c0fbf306fae13e97caa294d7c99a564bd97130
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCC3 PLXNC1 LRP1 SLC26A11 NCKAP1L

2.06e-0419812150b41b3d6c2db795320e8b65d40d85fb8b618cc34
ToppCellImmune-monocyte|World / Lineage, Cell type, age group and donor

TRPS1 NLRP1 PLXDC2 PLXNC1 NCKAP1L

2.06e-041981215d3622da252fd580f1dc5c7478a8e23df5ec083cf
ToppCellmLN-(4)_Monocyte|mLN / shred on region, Cell_type, and subtype

PLXDC2 TLR4 LRP1 ALDH3B1 FAM20A

2.11e-0419912156795ff31f92580195c9db776951f99d647484d24
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-CD8+_T_naive|ICU-SEP / Disease, condition lineage and cell class

TTC39B PDE6B UPF3A CHI3L2 TECTA

2.11e-041991215ae5936ff37a333d66840dd1dfc59c4ce750625cd
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ABCC3 PLXDC2 TLR4 LRP1 FAM20A

2.11e-041991215b827dd8a249f904a0ff930a6c4d3b00fb7bc6fb1
DiseaseColorectal Carcinoma

ABCC3 ABCA4 ACACA MYO1B KCNB2 RRM2 PTPRD RPAP1 DUSP21 TLR4 DCHS1 LRP1 SORL1

3.04e-0670211313C0009402
Diseasenon-alcoholic fatty liver disease (biomarker_via_orthology)

ABCC3 ACACA IDE TLR4 ABCG5

5.18e-06651135DOID:0080208 (biomarker_via_orthology)
Diseasehearing impairment

TECTA FANCA TLR4 STAG2

5.58e-04981134C1384666
Diseaseresponse to hydrochlorothiazide, diastolic blood pressure change measurement

PKD1L1 PLCXD3

6.41e-04101132EFO_0005202, EFO_0006945
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

AANAT IDE PPP1R3A PRKAA1

7.24e-041051134DOID:9352 (implicated_via_orthology)
Diseasepsychosocial stress measurement

PLCXD3 AQR

7.82e-04111132EFO_0006783
DiseaseMalignant neoplasm of breast

ABCA4 PIGS SPATA18 TECTA PPP1R3A PTPRD OTOGL PRKAA1 UTP20 CLUL1 VPS13B SORL1

8.59e-04107411312C0006142
Diseasecholestasis (biomarker_via_orthology)

ABCC3 PRKAA1 ABCG5

8.86e-04491133DOID:13580 (biomarker_via_orthology)
DiseaseT-cell surface glycoprotein CD3 epsilon chain measurement

PIKFYVE PLXDC2

1.10e-03131132EFO_0802114
Diseaseinterleukin 1 receptor antagonist measurement

KANK4 UBE3C SLC26A11

1.11e-03531133EFO_0004754
DiseaseDisorder of eye

RPGRIP1 ABCA4 PDE6C PDE6B MKS1

1.37e-032121135C0015397
DiseaseMeckel-Gruber syndrome

RPGRIP1 MKS1

1.48e-03151132C0265215
Diseaseamyloid-beta measurement, Alzheimer's disease biomarker measurement

PIGN PLXDC2

1.68e-03161132EFO_0005194, EFO_0006514
DiseaseFeeding difficulties

POLR2A MSL3

2.14e-03181132C0232466
DiseaseMeckel syndrome type 1

RPGRIP1 MKS1

2.14e-03181132C3714506
Diseasevitiligo (is_implicated_in)

NLRP1 TLR4

2.91e-03211132DOID:12306 (is_implicated_in)
DiseaseDrugs used in diabetes use measurement

RPAP1 CLEC14A NUS1 SCTR UBE3C

3.05e-032551135EFO_0009924
Diseasebrain infarction, neuritic plaque measurement, Lewy body dementia, cerebral amyloid angiopathy, neurofibrillary tangles measurement

KCNB2 PTPRD

3.19e-03221132EFO_0004277, EFO_0006790, EFO_0006792, EFO_0006797, EFO_0006798
DiseaseMyopia

POLR2A PGBD1 TOP6BL PTPRD UBE3C VPS13B

3.72e-033851136HP_0000545
DiseaseS-7-hydroxywarfarin to S-warfarin ratio measurement

TRPS1 RRM2 AQR

3.76e-03811133EFO_0803334

Protein segments in the cluster

PeptideGeneStartEntry
SFDPLASFILRTDHY

TMEM62

416

Q0P6H9
ATFHEAFPESSYLFN

FAM227B

261

Q96M60
FAPRHYTELLSDDFT

CHTF18

286

Q8WVB6
FTLGAPTISFFLEHF

CCNO

226

P22674
HYSDPFILFLFLLAF

ABCA4

726

P78363
LLEHRFDYIFFTGSP

ALDH3B1

176

P43353
SETSIFDVLPNFFYH

ACACA

1126

Q13085
LSFDPAFDELPHYAL

BRIX1

166

Q8TDN6
FFELDVYHSDGTPLT

CRAT

211

P43155
AFAHFPELYDFALSN

AQR

341

O60306
VTEVSTFFPFHEYFA

AQR

961

O60306
IDPFLCSHLIYSFAS

CHI3L2

51

Q15782
PDESSEALPFFLFFH

AFMID

81

Q63HM1
SFVLEFHFEPNEYFT

NAP1L1

211

P55209
SLVHKVFLDFFTYAP

PUM3

326

Q15397
SDPFRFTTFYIHFAL

ABCC3

166

O15438
FVRFLAEYHDDFFPE

MSL3P1

411

P0C860
LRHFDVLFAEFELSY

ZFYVE28

161

Q9HCC9
FSEATHAPISIYFDF

RAD9B

236

Q6WBX8
LIDFARAFHQDSYPF

MMP25

171

Q9NPA2
EDEYDPVFLAPAFHF

DCHS1

2806

Q96JQ0
HDLPDFDISAYFSSA

DUSP13

96

Q6B8I1
DLSYLLDHLASDPFF

GPN2

201

Q9H9Y4
HFFYILTIPSDLKFA

HHATL

266

Q9HCP6
DILTYEEFHPFLFSQ

NEMF

266

O60524
LYHTDVSLFGEPTEF

GOLGA4

2161

Q13439
PRALDFHAETGFIYF

LRP1

561

Q07954
SYDSDFTAPLVLYHV

SPATA18

456

Q8TC71
HATDYFLANFFSEFP

CFAP65

1621

Q6ZU64
VHDFYLTTFDSFPEL

HECTD2

151

Q5U5R9
DGSTDFLLVAAPFYH

ITGAE

526

P38570
LTLAFTVLLFHFDYP

PCNX3

1201

Q9H6A9
PLYIFFFVSVDLAHR

PCNX4

216

Q63HM2
LDYKHFALRTFFPES

PLXNC1

1016

O60486
PTTFDIYEFHFSDLE

PDE6B

496

P35913
LYEFRFSDFPLTEHG

PDE6C

506

P51160
PLSYSFIHLCFQEFF

NLRP1

616

Q9C000
LPSHLNISYEDFFSA

NUS1

266

Q96E22
LFLRFLAEYHDDFFP

MSL3

486

Q8N5Y2
SDFAAATHPRAFYLS

MPHOSPH9

181

Q99550
FSVFEHTIFPSEYLS

NCKAP1L

696

P55160
EFYFDRHPGFFLSLL

KCNS1

101

Q96KK3
LHFPLVSDSFREYSA

PLA2G4B

696

P0C869
IFEYFNTAPLAHDLT

CDC42BPB

951

Q9Y5S2
DPYPHQFATALFSFL

HUWE1

376

Q7Z6Z7
FAFILHLADQYDPLY

LRRC8B

366

Q6P9F7
LTYHGVVFFIPDFLA

MAS1L

136

P35410
TDIFHTEEYVLAPLF

PPP1R3A

96

Q16821
FSIYLLHLAAADFLF

MRGPRG

46

Q86SM5
IPALFSFLTYRFGHD

OR52R1

256

Q8NGF1
SIPFFLSYHLTDEPF

NPY6R

166

Q99463
RLEVQSFLDFAPHYF

PIKFYVE

1881

Q9Y2I7
PFSFHFFEDSLEDLL

DNAJB7

106

Q7Z6W7
VILFFHPELEFSSDF

EFCAB5

1386

A4FU69
STHPVDFLDAFRTFY

KLHL23

16

Q8NBE8
EYFFDRHPGAFTSIL

KCNB2

86

Q92953
LPFAFYSLLSYFHED

FANCA

1331

O15360
AEEFHPYIPFFATFD

CASQ1

201

P31415
DLDAFVRFEFHYPNS

CC2D1B

721

Q5T0F9
FFANSLLHYAKEFLP

C1orf112

251

Q9NSG2
FITSFHPSLFAELDA

C1orf112

426

Q9NSG2
YFSAALLAPHLIGEF

ABCG5

501

Q9H222
GAVIDPTLLHYSFAF

CADPS2

706

Q86UW7
SVETPYGFHLDLDFL

KANK4

26

Q5T7N3
RYFCTPHDFLHFLLD

KNDC1

1281

Q76NI1
FFHILNLFFPSIYDV

CNOT8

181

Q9UFF9
FEFFSPFAYVDPLHC

IDE

576

P14735
VFLSPYPDSAFRFVH

PKD1L1

881

Q8TDX9
TVDGEFLHYIFPLQF

POPDC3

166

Q9HBV1
FLHYIFPLQFLDSPE

POPDC3

171

Q9HBV1
LYDFFDPIADLIHTI

DUSP21

81

Q9H596
QFEATSPRYFFHDAI

OTOGL

56

Q3ZCN5
YIAAHFDVLPTEFTL

PTPRD

1191

P23468
HTPVYFFLANLSFTD

OR1D2

56

P34982
AFFDPSLLHLLYFPD

PIGS

501

Q96S52
LEVSSVFPDFYLHLG

HEXA

306

P06865
ELYFFHELSPGSCFF

TARS1

331

P26639
DFYPHFPEFFLTITS

UTP20

121

O75691
TLVRYFANEPFADFH

SORL1

401

Q92673
YRFFTFSDHDTAIIP

RPGRIP1

826

Q96KN7
EDALVPFYERFSFHA

AANAT

161

Q16613
LLFLFVDFHSAFPVQ

TOP6BL

326

Q8N6T0
PVSFTDLAHVFYLSY

TMEM191A

116

Q9H0A3
SDLFFHDYSIAPLFV

RFC1

871

P35251
DAAPFSYHSTFLLAD

SCRN2

151

Q96FV2
LPAHDYFEFFAADLS

UPF3A

91

Q9H1J1
ETPVDFFYFIDFQRH

FAM20A

246

Q96MK3
LSFDFPFYGHFLREI

PLXDC2

161

Q6UX71
LFYADHPFIFLVRDT

SERPINH1

381

P50454
DFEIPHFFCELTYIL

OR7D2

171

Q96RA2
AFELATGDYLFEPHS

SRPK1

541

Q96SB4
PYHLCFDSFFTSVKL

PGBD1

621

Q96JS3
SLDPLDFRRFVAHFY

PGBD1

786

Q96JS3
YFVPLHSFFLTPDSF

PARVA

306

Q9NVD7
FYLATSPPDSFLDDH

PRKAA1

351

Q13131
HPSFFYATPSADFLL

ANKUB1

461

A6NFN9
YFEDDHPFLLTSFSA

CLGN

396

O14967
SYRAPFQLHSAALDF

CLEC14A

191

Q86T13
HFISDTDLTEPYFFP

CLUL1

216

Q15846
LHTFDGASYAFPSEF

TECTA

721

O75443
LAIPGSHDSFSFYID

PLCXD3

31

Q63HM9
FTTPDVDVLLFHYES

TRPS1

621

Q9UHF7
DATTFLYFSFFAPLI

TPRA1

261

Q86W33
AYLFAHAVDFVPSEE

TSR1

251

Q2NL82
VFDHFSDPGLLTALY

TNFAIP8L2

146

Q6P589
RPEHDDFFISLLESY

THOC2

221

Q8NI27
DHYLVPFTLFELASL

TTC39B

621

Q5VTQ0
YLLSSVSFFFVPLAE

SLC16A4

466

O15374
FSYPFTFEAFFLHED

MKS1

371

Q9NXB0
LIHKFFPDAFDYAEL

SMTNL1

416

A8MU46
PEERYFISHVLAFFA

RRM2

121

P31350
TFHEPAYAVLLAFLS

SLC26A11

116

Q86WA9
FFFLESELHEHAAYL

STAG2

466

Q8N3U4
YDHLPALFFVAESVL

TMEM232

131

C9JQI7
SYLAGLTPTEFFFHA

POLR2A

826

P24928
FGIHYIVFAFSPEDA

SCTR

351

P47872
RIISHPFFNDFTFDY

ST14

696

Q9Y5Y6
PFFNDFTFDYDIALL

ST14

701

Q9Y5Y6
LDTFSVHFYIFFGPS

TMEM8B

46

A6NDV4
SFPDLYANFLDHFEA

RPAP1

1206

Q9BWH6
FASIFDIYFTSPLVH

PIGN

16

O95427
ILSHFPEELSLAFVY

TAMM41

16

Q96BW9
HPELIDAAFTNFFFF

POGLUT2

326

Q6UW63
FIHLPFLANSVALFY

ZDHHC17

386

Q8IUH5
YIASDHTPLSFSVFE

VPS13B

3606

Q7Z7G8
LRHLGSYSFFSFPEL

TLR4

66

O00206
EEFLAAPFTDQIFHF

UBE3C

266

Q15386
IIPLFYLFSSLFSHS

UBE3C

496

Q15386
FSALFPSYVALHFLG

XKR8

221

Q9H6D3
NFYELSPHIFALSDE

MYO1B

76

O43795