Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone phosphatase activity	EYA1 EYA3	8.19e-05	3	105	2	GO:0140789
GeneOntologyMolecularFunction	histone H2AXY142 phosphatase activity	EYA1 EYA3	8.19e-05	3	105	2	GO:0140793
GeneOntologyMolecularFunction	hyaluronan synthase activity	HAS1 HAS2	1.63e-04	4	105	2	GO:0050501
MousePheno	absent myocardial trabeculae	EPHB4 HIF1A ARID1A HAS2	7.79e-06	22	83	4	MP:0000293
Domain	EYA_dom	EYA4 EYA1 EYA3	6.49e-07	4	103	3	IPR006545
Domain	EYA_fam	EYA4 EYA1 EYA3	6.49e-07	4	103	3	IPR028472
Domain	HAS/NodC	HAS1 HAS2	9.00e-05	3	103	2	IPR026107
Domain	-	ALDH1L1 MTFMT	9.00e-05	3	103	2	3.10.25.10
Domain	Formyl_trans_C	ALDH1L1 MTFMT	9.00e-05	3	103	2	PF02911
Domain	Formyl_trans_C	ALDH1L1 MTFMT	9.00e-05	3	103	2	IPR005793
Domain	SAM	SHANK1 EPHB4 DGKH ARAP1 EPHA5	1.26e-04	88	103	5	SM00454
Domain	-	ALDH1L1 MTFMT	1.79e-04	4	103	2	3.40.50.170
Domain	Formyl_transf_N	ALDH1L1 MTFMT	1.79e-04	4	103	2	IPR002376
Domain	Formyl_trans_N	ALDH1L1 MTFMT	1.79e-04	4	103	2	PF00551
Domain	SAM_DOMAIN	SHANK1 EPHB4 DGKH ARAP1 EPHA5	1.81e-04	95	103	5	PS50105
Domain	SAM	SHANK1 EPHB4 DGKH ARAP1 EPHA5	1.99e-04	97	103	5	IPR001660
Domain	Formyl_transferase_C-like	ALDH1L1 MTFMT	2.98e-04	5	103	2	IPR011034
Domain	-	SHANK1 EPHB4 DGKH ARAP1 EPHA5	3.02e-04	106	103	5	1.10.150.50
Domain	SAM/pointed	SHANK1 EPHB4 DGKH ARAP1 EPHA5	4.75e-04	117	103	5	IPR013761
Domain	SAM_1	SHANK1 EPHB4 ARAP1 EPHA5	5.42e-04	68	103	4	PF00536
Domain	PH_dom-like	SPRED2 DGKH PTK2 PRKD3 SPTBN4 PLEKHA5 PLCH1 ARAP1	2.47e-03	426	103	8	IPR011993
Domain	RECEPTOR_TYR_KIN_V_2	EPHB4 EPHA5	2.62e-03	14	103	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHB4 EPHA5	2.62e-03	14	103	2	PS00790
Domain	Tyr_kinase_rcpt_V_CS	EPHB4 EPHA5	2.62e-03	14	103	2	IPR001426
Domain	ATPase_dyneun-rel_AAA	DNAH3 MDN1	2.62e-03	14	103	2	IPR011704
Domain	EphA2_TM	EPHB4 EPHA5	2.62e-03	14	103	2	PF14575
Domain	Ephrin_rcpt_lig-bd_dom	EPHB4 EPHA5	2.62e-03	14	103	2	IPR001090
Domain	Eph_TM	EPHB4 EPHA5	2.62e-03	14	103	2	IPR027936
Domain	EPH_lbd	EPHB4 EPHA5	2.62e-03	14	103	2	SM00615
Domain	Ephrin_lbd	EPHB4 EPHA5	2.62e-03	14	103	2	PF01404
Domain	Tyr_kinase_ephrin_rcpt	EPHB4 EPHA5	2.62e-03	14	103	2	IPR016257
Domain	EPH_LBD	EPHB4 EPHA5	2.62e-03	14	103	2	PS51550
Domain	AAA_5	DNAH3 MDN1	2.62e-03	14	103	2	PF07728
Domain	PH	DGKH PRKD3 SPTBN4 PLEKHA5 PLCH1 ARAP1	4.42e-03	278	103	6	SM00233
Domain	PH_DOMAIN	DGKH PRKD3 SPTBN4 PLEKHA5 PLCH1 ARAP1	4.50e-03	279	103	6	PS50003
Domain	PH_domain	DGKH PRKD3 SPTBN4 PLEKHA5 PLCH1 ARAP1	4.57e-03	280	103	6	IPR001849
Domain	-	SACS TOP2B	5.36e-03	20	103	2	3.30.565.10
Pathway	WP_NEOVASCULARIZATION_PROCESSES	EPHB4 HIF1A NOTCH4 SMAD3	3.84e-05	37	73	4	M39506
Pubmed	EYA4, a novel vertebrate gene related to Drosophila eyes absent.	EYA4 EYA1 EYA3	5.47e-07	6	106	3	9887327
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	POLE EYA1 ARID1A ARMCX3 EHMT2 KIAA1958 BUB3 CCDC9 TOP2B SMAD3	1.82e-06	469	106	10	27634302
Pubmed	PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression.	L3MBTL2 EHMT2 MGA	4.46e-06	11	106	3	35933409
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	PFKM ARID1A MDN1 EHMT2 MGA	4.50e-06	79	106	5	26446488
Pubmed	Coding sequence of a hyaluronan synthase homologue expressed during expansion of the mouse cumulus-oocyte complex.	HAS1 HAS2	9.20e-06	2	106	2	9016821
Pubmed	Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy.	HAS1 HAS2	9.20e-06	2	106	2	22785117
Pubmed	The genes for sensory perception of sound should be considered in gene diagnosis of congenital sensorineural hearing loss and microtia.	EYA1 BUB3	9.20e-06	2	106	2	35000142
Pubmed	Hyaluronan Synthases' Expression and Activity Are Induced by Fluid Shear Stress in Bone Marrow-Derived Mesenchymal Stem Cells.	HAS1 HAS2	9.20e-06	2	106	2	33803805
Pubmed	Dynamic changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth.	HAS1 HAS2	9.20e-06	2	106	2	22529214
Pubmed	Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma.	HAS1 HAS2	9.20e-06	2	106	2	27184066
Pubmed	Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression.	HIF1A SMAD3	9.20e-06	2	106	2	11486006
Pubmed	Deficiency of hyaluronan synthase 1 (Has1) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage.	HAS1 HAS2	9.20e-06	2	106	2	26521733
Pubmed	Cell surface fucosylation does not affect development of colon tumors in mice with germline Smad3 mutation.	FUT2 SMAD3	9.20e-06	2	106	2	17264540
Pubmed	Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells.	HIF1A EHMT2	9.20e-06	2	106	2	16982742
Pubmed	Syndecan-2 cytoplasmic domain up-regulates matrix metalloproteinase-7 expression via the protein kinase Cγ-mediated FAK/ERK signaling pathway in colon cancer.	PTK2 MMP7	9.20e-06	2	106	2	28821612
Pubmed	Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer.	HIF1A EHD2	9.20e-06	2	106	2	35177645
Pubmed	Hypoxia-Inducible Factor 1α and AT-Rich Interactive Domain-Containing Protein 1A Expression in Pituitary Adenomas: Association with Pathological, Clinical, and Radiological Features.	HIF1A ARID1A	9.20e-06	2	106	2	30292665
Pubmed	[Protein kinase D3 is involved in negative regulation of MMP-7 in prostate cancer cells].	PRKD3 MMP7	9.20e-06	2	106	2	20813660
Pubmed	Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization.	HAS1 HAS2	9.20e-06	2	106	2	20823158
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	EPHB4 ITCH L3MBTL2 POLE PFKM RRP1 MRPL17 MDN1 SACS UTP15 EHMT2 RAB3GAP2 PLEKHA5 MRPL3 PLCH1 TOP2B	1.12e-05	1487	106	16	33957083
Pubmed	Mechanisms underlying TGF-beta1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis.	HIF1A SMAD3	2.76e-05	3	106	2	17053163
Pubmed	Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells.	HAS1 HAS2	2.76e-05	3	106	2	16564133
Pubmed	Analysis of human hyaluronan synthase gene transcriptional regulation and downstream hyaluronan cell surface receptor mobility in myofibroblast differentiation.	HAS1 HAS2	2.76e-05	3	106	2	25325984
Pubmed	Mammalian hyaluronan synthases: investigation of functional relationships in vivo.	HAS1 HAS2	2.76e-05	3	106	2	10093717
Pubmed	Cyclooxygenase inhibitors repress vascular hyaluronan-synthesis in murine atherosclerosis and neointimal thickening.	HAS1 HAS2	2.76e-05	3	106	2	19320776
Pubmed	Hyaluronan Regulates Eyelid and Meibomian Gland Morphogenesis.	HAS1 HAS2	2.76e-05	3	106	2	30046813
Pubmed	Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3.	HAS1 HAS2	2.76e-05	3	106	2	25795779
Pubmed	Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.	HAS1 HAS2	2.76e-05	3	106	2	23303191
Pubmed	Hyaluronan expressed by the hematopoietic microenvironment is required for bone marrow hematopoiesis.	HAS1 HAS2	2.76e-05	3	106	2	22654110
Pubmed	Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells.	HAS1 HAS2	2.76e-05	3	106	2	11790779
Pubmed	Association of hyaluronic acid family members (HAS1, HAS2, and HYAL-1) with bladder cancer diagnosis and prognosis.	HAS1 HAS2	2.76e-05	3	106	2	20960509
Pubmed	Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis.	EPHB4 EPHA5	2.76e-05	3	106	2	8152808
Pubmed	A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.	EYA1 EYA3	2.76e-05	3	106	2	9020840
Pubmed	HIF1A is Overexpressed in Medulloblastoma and its Inhibition Reduces Proliferation and Increases EPAS1 and ATG16L1 Methylation.	ATG16L1 HIF1A	2.76e-05	3	106	2	28302031
Pubmed	Three vertebrate hyaluronan synthases are expressed during mouse development in distinct spatial and temporal patterns.	HAS1 HAS2	2.76e-05	3	106	2	15765504
Pubmed	Hyaluronan Modulates the Biomechanical Properties of the Cornea.	HAS1 HAS2	2.76e-05	3	106	2	36478198
Pubmed	Hyaluronan Derived From the Limbus is a Key Regulator of Corneal Lymphangiogenesis.	HAS1 HAS2	2.76e-05	3	106	2	30897620
Pubmed	G9a Promotes Invasion and Metastasis of Non-Small Cell Lung Cancer through Enhancing Focal Adhesion Kinase Activation via NF-κB Signaling Pathway.	PTK2 EHMT2	2.76e-05	3	106	2	33298547
Pubmed	A comparative study of Eya1 and Eya4 protein function and its implication in branchio-oto-renal syndrome and DFNA10.	EYA4 EYA1	2.76e-05	3	106	2	15492887
Pubmed	In vitro synthesis of hyaluronan by a single protein derived from mouse HAS1 gene and characterization of amino acid residues essential for the activity.	HAS1 HAS2	2.76e-05	3	106	2	10617644
Pubmed	Involvement of hyaluronan in regulation of fibroblast phenotype.	HAS1 HAS2	2.76e-05	3	106	2	17611197
Pubmed	Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration.	HIF1A EHMT2	2.76e-05	3	106	2	29860315
Pubmed	Expression regulation of hyaluronan synthase in corneal endothelial cells.	HAS1 HAS2	2.76e-05	3	106	2	11006212
Pubmed	SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway.	HIF1A PTK2	2.76e-05	3	106	2	27495308
Pubmed	MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis.	HIF1A SMAD3	2.76e-05	3	106	2	28471448
Pubmed	An in situ hybridization study of Hyaluronan synthase (Has) mRNA in developing mouse molar and incisor tooth germs.	HAS1 HAS2	2.76e-05	3	106	2	27289075
Pubmed	Eyes absent represents a class of protein tyrosine phosphatases.	EYA1 EYA3	2.76e-05	3	106	2	14628052
Pubmed	TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate.	HAS1 HAS2	2.76e-05	3	106	2	16786194
Pubmed	Notch4-dependent antagonism of canonical TGF-β1 signaling defines unique temporal fluctuations of SMAD3 activity in sheared proximal tubular epithelial cells.	NOTCH4 SMAD3	2.76e-05	3	106	2	23576639
Pubmed	A cross-talk between hypoxia and TGF-beta orchestrates erythropoietin gene regulation through SP1 and Smads.	HIF1A SMAD3	2.76e-05	3	106	2	14741200
Pubmed	Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus.	MEP1B MUC2	2.76e-05	3	106	2	25114233
Pubmed	Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.	HAS1 HAS2	2.76e-05	3	106	2	11431361
Pubmed	Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties.	HAS1 HAS2	2.76e-05	3	106	2	10455188
Pubmed	Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family.	HAS1 HAS2	2.76e-05	3	106	2	9442026
Pubmed	Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space.	HAS1 HAS2	2.76e-05	3	106	2	24790187
Pubmed	Perturbation of hyaluronan synthesis in the trabecular meshwork and the effects on outflow facility.	HAS1 HAS2	2.76e-05	3	106	2	22695958
Pubmed	Analysis of hyaluronic acid in the endometrium of women with polycystic ovary syndrome.	HAS1 HAS2	2.76e-05	3	106	2	30614308
Pubmed	Inhibition of hyaluronan synthases decreases matrix metalloproteinase-7 (MMP-7) expression and activity.	MMP7 HAS2	2.76e-05	3	106	2	19231585
Pubmed	Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways.	ITCH SMAD3	2.76e-05	3	106	2	15051726
Pubmed	Hyaluronan synthases.	HAS1 HAS2	2.76e-05	3	106	2	9206724
Pubmed	Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes.	HAS1 HAS2	2.76e-05	3	106	2	24057227
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	ATG16L1 POLE PSMD12 MDN1 SACS RAB3GAP2 BUB3 TOP2B	3.23e-05	400	106	8	35013556
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHANK1 ITCH PTK2 SPTBN4 MDN1 ARVCF EHMT2 PLEKHA5 BRSK1 BUB3 MGA KCNT1	3.84e-05	963	106	12	28671696
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	PTGES2 POLE DGKH PFKM ARMCX3 RRP1 MTFMT MRPL17 MDN1 UTP15 EHMT2 RAB3GAP2 MRPL3 SLC39A14 MGME1	4.87e-05	1496	106	15	32877691
Pubmed	Loss of Gata5 in mice leads to bicuspid aortic valve.	EPHB4 HAS2 NOTCH4	5.32e-05	24	106	3	21633169
Pubmed	Hyaluronan in cervical epithelia protects against infection-mediated preterm birth.	HAS1 HAS2	5.50e-05	4	106	2	25384213
Pubmed	HIF-1α Dependent Upregulation of ZIP8, ZIP14, and TRPA1 Modify Intracellular Zn2+ Accumulation in Inflammatory Synoviocytes.	HIF1A SLC39A14	5.50e-05	4	106	2	34198528
Pubmed	Hyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation.	HAS1 HAS2	5.50e-05	4	106	2	28863216
Pubmed	Growth and differentiation factor-9 promotes adhesive and motile capacity of prostate cancer cells by up-regulating FAK and Paxillin via Smad dependent pathway.	PTK2 SMAD3	5.50e-05	4	106	2	21042764
Pubmed	Dynamic states of cervical epithelia during pregnancy and epithelial barrier disruption.	HAS1 HAS2	5.50e-05	4	106	2	36718364
Pubmed	Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis.	EYA4 EYA3	5.50e-05	4	106	2	19901965
Pubmed	Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling.	NOTCH4 SMAD3	5.50e-05	4	106	2	16007227
Pubmed	Peritoneal adhesion and angiogenesis in ovarian carcinoma are inversely regulated by hyaluronan: the role of gonadotropins.	HAS1 HAS2	5.50e-05	4	106	2	20072653
Pubmed	Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta.	HAS1 HAS2	5.50e-05	4	106	2	14636845
Pubmed	Nitric oxide alters hyaluronan deposition by airway smooth muscle cells.	HAS1 HAS2	5.50e-05	4	106	2	29966020
Pubmed	Misexpression of the eyes absent family triggers the apoptotic program.	EYA1 EYA3	5.50e-05	4	106	2	11700312
Pubmed	Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5.	PRDM5 EHMT2	5.50e-05	4	106	2	17636019
Pubmed	Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.	HAS1 HAS2	5.50e-05	4	106	2	23560496
Pubmed	Putative hyaluronan synthase mRNA are expressed in mouse skin and TGF-beta upregulates their expression in cultured human skin cells.	HAS1 HAS2	5.50e-05	4	106	2	9457904
Pubmed	Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways.	HIF1A SMAD3	5.50e-05	4	106	2	12228247
Pubmed	Eya4-deficient mice are a model for heritable otitis media.	EYA4 EYA1	5.50e-05	4	106	2	18219393
Pubmed	The control and importance of hyaluronan synthase expression in palatogenesis.	HAS1 HAS2	5.50e-05	4	106	2	23382716
Pubmed	Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3.	HIF1A SMAD3	5.50e-05	4	106	2	27503806
Pubmed	Hyaluronan synthase induction and hyaluronan accumulation in mouse epidermis following skin injury.	HAS1 HAS2	5.50e-05	4	106	2	15854028
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	POLE PSMD12 PFKM ARID1A RNF17 DOCK5 MDN1 BUB3 ARAP1	7.53e-05	582	106	9	20467437
Pubmed	Dachshund homologues play a conserved role in islet cell development.	EYA4 EYA1 EYA3	7.63e-05	27	106	3	20869363
Pubmed	Cellular response to hypoxia involves signaling via Smad proteins.	HIF1A SMAD3	9.15e-05	5	106	2	12411310
Pubmed	Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya.	EYA1 EYA3	9.15e-05	5	106	2	10490620
Pubmed	Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma.	HAS1 HAS2	9.15e-05	5	106	2	20875124
Pubmed	Notch4 normalization reduces blood vessel size in arteriovenous malformations.	EPHB4 NOTCH4	9.15e-05	5	106	2	22261032
Pubmed	Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode.	EYA1 EYA3	9.15e-05	5	106	2	9006082
Pubmed	Eyes absent: a gene family found in several metazoan phyla.	EYA1 EYA3	9.15e-05	5	106	2	9195991
Pubmed	Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content.	HAS1 HAS2	9.15e-05	5	106	2	19435493
Pubmed	Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions.	HIF1A SMAD3	9.15e-05	5	106	2	21057546
Pubmed	A pericellular hyaluronan matrix is required for the morphological maturation of cortical neurons.	HAS1 HAS2	9.15e-05	5	106	2	32623025
Pubmed	Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.	HIF1A NOTCH4	1.37e-04	6	106	2	18299578
Pubmed	bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells.	HAS1 HAS2	1.37e-04	6	106	2	19577615
Pubmed	FGF9 Promotes Expression of HAS2 in Palatal Elevation via the Wnt/β-Catenin/TCF7L2 Pathway.	HAS1 HAS2	1.37e-04	6	106	2	36358989
Pubmed	Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts.	HAS1 HAS2	1.91e-04	7	106	2	26518873
Pubmed	Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis.	EPHB4 NOTCH4	1.91e-04	7	106	2	18952909
GeneFamily	EYA transcriptional coactivator and phosphatases	EYA4 EYA1 EYA3	3.86e-07	4	84	3	1044
GeneFamily	Sterile alpha motif domain containing	SHANK1 EPHB4 DGKH ARAP1 EPHA5	5.56e-05	88	84	5	760
GeneFamily	Glycosyltransferase family 2	HAS1 HAS2	3.16e-04	6	84	2	428
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB4 EPHA5	1.87e-03	14	84	2	1095
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DGKH PRKD3 SPTBN4 PLEKHA5 ARAP1	2.73e-03	206	84	5	682
CoexpressionAtlas	DevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#4_top-relative-expression-ranked_100	EYA4 EYA1 DOCK5 HAS2	5.35e-06	24	104	4	gudmap_developingKidney_e11.5_metaneph mesench_100_k4
CoexpressionAtlas	DevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#2_top-relative-expression-ranked_200	EYA4 EYA1 DOCK5 HAS2	2.25e-05	34	104	4	gudmap_developingKidney_e11.5_metaneph mesench_200_k2
Disease	eye disease (implicated_via_orthology)	EYA4 EYA1 EYA3	8.20e-07	6	103	3	DOID:5614 (implicated_via_orthology)
Disease	branchiootorenal syndrome (implicated_via_orthology)	EYA4 EYA1 EYA3	1.43e-06	7	103	3	DOID:14702 (implicated_via_orthology)
Disease	creatinine measurement	HIF1A EYA4 DGKH ALDH1L1 ADGRV1 EYA1 ARID1A ARMCX3 RGS7 BDKRB2 TINAGL1 PNPLA7 IGSF21 SMAD3	9.50e-06	995	103	14	EFO_0004518
Disease	glycogen storage disease VII (implicated_via_orthology)	HIF1A PFKM	1.21e-05	2	103	2	DOID:11721 (implicated_via_orthology)
Disease	Crohn Disease	ATG16L1 FUT2 MUC2 SMAD3	2.85e-05	50	103	4	C0010346
Disease	Colorectal Carcinoma	SHANK1 DNAH3 EYA4 POLE ALDH1L1 ARID1A SACS IGSF21 PIGO SMAD3	1.76e-04	702	103	10	C0009402
Disease	serum alanine aminotransferase measurement	PTGES2 ITCH ALDH1L1 EYA1 ARID1A TRANK1 TRMT44 APOL5 FUT2 NOTCH4 ARAP1	2.30e-04	869	103	11	EFO_0004735
Disease	endometrial cancer (is_marker_for)	MMP7 NOTCH4 SMAD3	2.49e-04	35	103	3	DOID:1380 (is_marker_for)
Disease	X-26054 measurement	FUT2 C4orf33	2.51e-04	7	103	2	EFO_0800939
Disease	Autosomal Dominant Nocturnal Frontal Lobe Epilepsy	DEPDC5 KCNT1	2.51e-04	7	103	2	C3696898
Disease	cancer (implicated_via_orthology)	POLE PSMD12 ARID1A DEPDC5 TOP2B NOTCH4	3.64e-04	268	103	6	DOID:162 (implicated_via_orthology)
Disease	hemangiopericytoma (is_marker_for)	EPHB4 NOTCH4	4.28e-04	9	103	2	DOID:264 (is_marker_for)
Disease	bringing up phlegm, sputum or mucus on most days, self-reported	FUT2 MUC2	4.28e-04	9	103	2	EFO_0009824
Disease	Spastic Paraplegia	SPG7 RAB3GAP2	4.28e-04	9	103	2	C0037772
Disease	bladder neck obstruction (biomarker_via_orthology)	HIF1A MMP7	4.28e-04	9	103	2	DOID:13948 (biomarker_via_orthology)
Disease	Crohn's disease of large bowel	ATG16L1 FUT2 SMAD3	4.93e-04	44	103	3	C0156147
Disease	IIeocolitis	ATG16L1 FUT2 SMAD3	4.93e-04	44	103	3	C0949272
Disease	Crohn's disease of the ileum	ATG16L1 FUT2 SMAD3	4.93e-04	44	103	3	C0267380
Disease	Regional enteritis	ATG16L1 FUT2 SMAD3	4.93e-04	44	103	3	C0678202
Disease	Asymmetric crying face association	EYA1 ARVCF	5.33e-04	10	103	2	C0431406
Disease	endometrial hyperplasia (is_marker_for)	PTK2 MMP7	5.33e-04	10	103	2	DOID:0080365 (is_marker_for)
Disease	smoking status measurement	PTGES2 SPG7 VSX1 PFKM PRDM5 PTK2 SPTBN4 TMTC4 RAB3GAP2 IGSF21 ICA1L SMAD3	7.31e-04	1160	103	12	EFO_0006527
Disease	Metastatic melanoma	EPHB4 PTK2 BRSK1	9.00e-04	54	103	3	C0278883
Disease	N-acetylglycine measurement	ALDH1L1 MGME1	1.07e-03	14	103	2	EFO_0021002
Disease	Malignant neoplasm of skin	HIF1A POLE NOTCH4	1.17e-03	59	103	3	C0007114
Disease	Skin Neoplasms	HIF1A POLE NOTCH4	1.17e-03	59	103	3	C0037286
Disease	T-Cell Lymphoma	ARID1A MGA	1.40e-03	16	103	2	C0079772
Disease	phosphatidylcholine 38:6 measurement	TMTC4 DEPDC5	1.40e-03	16	103	2	EFO_0010388
Disease	hearing loss	EYA4 PTK2 UTP15	1.68e-03	67	103	3	EFO_0004238
Disease	ischemia (biomarker_via_orthology)	PTK2 MUC2	1.78e-03	18	103	2	DOID:326 (biomarker_via_orthology)
Disease	Takayasu arteritis	EPHB4 TRANK1 EHMT2 NOTCH4	1.83e-03	148	103	4	EFO_1001857
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	SHANK1 CASP2 ARID1A SPTBN4	1.83e-03	148	103	4	C0279702
Disease	autoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis	ATG16L1 FUT2 SMAD3	1.91e-03	70	103	3	EFO_0000384, EFO_0000676, EFO_0000729, EFO_0001060, EFO_0002609, EFO_0003898, EFO_0005140, EFO_0006812, MONDO_0005147, MONDO_0007915, MONDO_0015517
Disease	pars opercularis volume measurement	CWF19L2 TMTC4	2.66e-03	22	103	2	EFO_0010319
Disease	pulmonary hypertension (biomarker_via_orthology)	HIF1A HAS1 HAS2	2.79e-03	80	103	3	DOID:6432 (biomarker_via_orthology)
Disease	chronic hepatitis B virus infection	EHMT2 NOTCH4	3.17e-03	24	103	2	EFO_0004239
Disease	Ureteral obstruction	MMP7 SMAD3	3.17e-03	24	103	2	C0041956
Disease	smoking behavior, BMI-adjusted waist-hip ratio	EYA4 EYA1 EHMT2	3.43e-03	86	103	3	EFO_0004318, EFO_0007788

Protein segments in the cluster

Peptide	Gene	Start	Entry
GRMRGVRWAKLYSLV	BDKRB2	166	P30411
RMSRGETKWEGKAYL	C4orf33	106	Q8N1A6
MWATYIRATVRKERG	ARVCF	696	O00192
GMDRRVKLWEVFGEK	ATG16L1	341	Q676U5
RVYGALMWALGKVVG	EHD2	231	Q9NZN4
LGRIWKLSDVDRDGM	EHD2	486	Q9NZN4
AYRSVGEWLEAIKMG	EPHA5	966	P54756
GEWLEAIKMGRYTEI	EPHA5	971	P54756
RRVKGTFGEIMVYWE	ADGRV1	4671	Q8WXG9
GRRVLVWDLRNMGYV	BUB3	156	O43684
QLYRTAKMGWGVRAL	EHMT2	1041	Q96KQ7
MGYARKVGWVTAGLV	ARMCX3	1	Q9UH62
QGGVDWMRKLAFRYR	EYA3	406	Q99504
EWQMDKGRRSYGDIL	INTS10	271	Q9NVR2
NMDYRLMWEVRGSKG	PRDM5	51	Q9NQX1
LMWEVRGSKGEVLYI	PRDM5	56	Q9NQX1
LYELGGEPERKMWVD	ARID1A	1011	O14497
LDVARGIAIRMWKGY	RAB3GAP2	411	Q9H2M9
GIAIRMWKGYRDAQI	RAB3GAP2	416	Q9H2M9
DQYIGRGDMWRLKKS	DEPDC5	106	O75140
KVVWGTADIMIGFAR	MMP7	146	P09237
GVLIDAMRKGYWIIL	MDN1	1136	Q9NU22
SVRPGWEYIGRKMDV	HHATL	46	Q9HCP6
SVGEWLRAIKMGRYE	EPHB4	911	P54760
WGDEGLKRMFRRIYR	MEPCE	591	Q7L2J0
MRGIQYKWKESESRG	MGA	2751	Q8IWI9
RWKQRMILELGEDGF	MGME1	151	Q9BQP7
TDWKGYLMKRLVGSR	L3MBTL2	291	Q969R5
RMLAKRGGYVWVETQ	HIF1A	306	Q16665
WMREKRYLAEGETDT	KCNQ3	826	O43525
MKITEGDLWIRTYGR	KCNT1	991	Q5JUK3
KVYSRAGLTLMWNRE	MUC2	136	Q02817
RMEWKVKVRSDGTRY	PDZD4	621	Q76G19
WMSGKIKESYRNGRI	PFKM	686	P08237
EDGGLSWLRKSYLRM	CWF19L2	226	Q2TBE0
LWRRGAAVGFYTTKM	FAM169B	46	Q8N8A8
GGVDWMRKLAFRYRR	EYA1	426	Q99502
RGLAYLRDAWGILMD	KCNJ13	36	O60928
KEWAGMLKEIRYASG	KLHL41	576	O60662
EVLRSKGYNRSLDMW	PRKD3	746	O94806
RSEMDWAKVIAGGER	LURAP1	166	Q96LR2
RKGARWYSMEMAGIV	POLE	821	Q07864
RWSTLVEDYGMELRK	PSMD12	316	O00232
RTKNLMWYGVLGTRE	DGKH	801	Q86XP1
FDIWGRSGVLEKMLR	PNPLA7	1201	Q6ZV29
EYIRMVAEWRLSRGV	ITCH	736	Q96J02
WRFRVEMIKGGGTLE	CCDC105	71	Q8IYK2
VPAVRKWREAGMKVY	ENOPH1	136	Q9UHY7
IGTVDVGKARLMFWD	ARFRP1	61	Q13795
VRGGVDWMRKLAFRY	EYA4	471	O95677
WMVIVFTRKEDLAGG	GIMAP1	146	Q8WWP7
DGRMREIVWYRVTDG	IGSF21	51	Q96ID5
RAYLKLERGNLMGGW	CBLN1	166	P23435
KEIGFRIRDMWYNLG	DOCK5	1081	Q9H7D0
FLEGARWDRKTMQIG	DNAH3	4021	Q8TD57
MTGRERSEYLRWKQE	CCDC9	256	Q9Y3X0
RRGDYVHVMPKVWKG	FUT2	201	Q10981
KWGGKREVMYTAFRA	HAS2	186	Q92819
MSLYRSVVWFAKGLR	DHRS12	1	A0PJE2
LVYCKDGWIGVRSVM	MTFMT	321	Q96DP5
LRMNRLAGVGWRVDY	COMMD4	126	Q9H0A8
VIKGEKYDGRRADMW	BRSK1	201	Q8TDC3
KYDGRRADMWSCGVI	BRSK1	206	Q8TDC3
RWGGKREVMYTAFKA	HAS1	211	Q92839
GYRRDLMTAGVLWGL	FCRL2	391	Q96LA5
RMEQARTEYRGALLW	ICA1L	151	Q8NDH6
RTEYRGALLWMKDVS	ICA1L	156	Q8NDH6
LRGVAFVMVEDGWKL	SACS	3791	Q9NZJ4
KGVRYSDIGTLAWMI	SLC39A14	326	Q15043
DYVRIMWDRILSGRE	MEP1B	171	Q16820
AMRNTKRGSWYIEAL	CASP2	376	P42575
MDRYLLLVIWGEGKF	MTBP	1	Q96DY7
MGNIYRTEYGLKVWR	MRPL3	261	P09001
LVSAGGRYVKVWDML	UTP15	221	Q8TED0
RVKRWGFGMDEALKD	RGS7	326	P49802
EVWRLVRGTRYMKKD	SLC35D3	391	Q5M8T2
LLLLAGVGMVWGYRK	SUSD5	586	O60279
RGIDVRRRKIWDMYG	TRMT44	381	Q8IYL2
WGMTLDEGIRYRLGT	TINAGL1	166	Q9GZM7
MAKWLRDYLSFGGRR	SHD	1	Q96IW2
YGLRKEWLVGMLGAE	TOP2B	1051	Q02880
LQVIVWGNYGRMERK	RIMS4	196	Q9H426
SRYVLWKRMIEARGI	IQCA1L	701	A6NCM1
DLYVVGGSIPRRMWK	KBTBD4	286	Q9NVX7
LGCLEIRRSYWEMRG	PTK2	171	Q05397
IRRSYWEMRGNALEK	PTK2	176	Q05397
MVGLVSRLWVLYKGV	NEPRO	176	Q6NW34
GIRESRKEDEGWYLM	SLAMF1	106	Q13291
VYGGKEARTEEMKWR	PTGES2	221	Q9H7Z7
EWTGIDRLRLDKFYM	RRP1	106	P56182
AILWYVFRLAGMTGR	SPG7	266	Q9UQ90
GLWVRKDRDGRDMVY	NOTCH4	1326	Q99466
RRKMIGWIYLGLNSS	SYT14P1	146	Q58G82
GTEVKRRYLDWRALM	MSANTD4	66	Q8NCY6
AWRAGLRMGDFLIEV	SHANK1	711	Q9Y566
RWGKISARDRGRLMY	ALDH1L1	476	O75891
EMWLRKVIYGGEVWG	APOL5	26	Q9BWW9
TLYIQGERRLDFMGW	ARAP1	931	Q96P48
KRYAGTDMHWIGLSR	CLEC2A	106	Q6UVW9
AVRGSDTLWYRGKVM	RNF17	1236	Q9BXT8
DTLWYRGKVMEVVGG	RNF17	1241	Q9BXT8
KREKRWGGSSVMAEY	VSX1	221	Q9NZR4
LTSGGAGMLYVRWRI	TMTC4	276	Q5T4D3
RAVMKLERGEEPWVY	ZNF671	96	Q8TAW3
EGTWVDMTGARIAYK	CLEC3B	141	P05452
TIRMSFVKGWGAEYR	SMAD3	371	P84022
EVRTAKRGYAMILWF	TMEM121	66	Q9BTD3
MSLDKRQGEGLRIYW	TPRG1	156	Q6ZUI0
WLRDALAVYRMFGEV	SPTBN4	876	Q9H254
RINPREKIWMTGYED	SPRED2	216	Q7Z698
ARTWITGLKYLMAGI	PLCH1	116	Q4KWH8
GRRVVFMGDDTWKDL	PIGO	171	Q8TEQ8
DMVEDLYRRKAWAGA	TRANK1	2846	O15050
LYRRKAWAGAEEAMT	TRANK1	2851	O15050
VRRGWLYKQDSTGMK	PLEKHA5	171	Q9HAU0
WARVDEMRGYAEKLI	MRPL17	46	Q9NRX2
VWYEEQRMGLRSLRG	KIAA1958	666	Q8N8K9