Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP3A7 CYP11B1 CYP3A43 CYP11B2	1.53e-06	34	50	4	GO:0008395
GeneOntologyMolecularFunction	heme binding	CYP3A7 GUCY1A2 GUCY1B1 CYP11B1 CYP3A43 CYP11B2	2.29e-06	154	50	6	GO:0020037
GeneOntologyMolecularFunction	tetrapyrrole binding	CYP3A7 GUCY1A2 GUCY1B1 CYP11B1 CYP3A43 CYP11B2	3.30e-06	164	50	6	GO:0046906
GeneOntologyMolecularFunction	steroid 11-beta-monooxygenase activity	CYP11B1 CYP11B2	6.14e-06	2	50	2	GO:0004507
GeneOntologyMolecularFunction	corticosterone 18-monooxygenase activity	CYP11B1 CYP11B2	6.14e-06	2	50	2	GO:0047783
GeneOntologyMolecularFunction	monooxygenase activity	CYP3A7 FOXRED2 CYP11B1 CYP3A43 CYP11B2	1.00e-05	115	50	5	GO:0004497
GeneOntologyMolecularFunction	testosterone 6-beta-hydroxylase activity	CYP3A7 CYP3A43	6.12e-05	5	50	2	GO:0050649
GeneOntologyMolecularFunction	estrogen 2-hydroxylase activity	CYP3A7 CYP3A43	1.70e-04	8	50	2	GO:0101021
GeneOntologyMolecularFunction	guanylate cyclase activity	GUCY1A2 GUCY1B1	2.73e-04	10	50	2	GO:0004383
GeneOntologyMolecularFunction	estrogen 16-alpha-hydroxylase activity	CYP3A7 CYP3A43	3.33e-04	11	50	2	GO:0101020
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP11B1 CYP11B2	4.71e-04	13	50	2	GO:0016713
GeneOntologyMolecularFunction	retinoic acid 4-hydroxylase activity	CYP3A7 CYP3A43	5.49e-04	14	50	2	GO:0008401
GeneOntologyMolecularFunction	iron ion binding	CYP3A7 CYP11B1 CYP3A43 CYP11B2	7.88e-04	166	50	4	GO:0005506
GeneOntologyMolecularFunction	GABA receptor binding	PLCL2 PLCL1	1.13e-03	20	50	2	GO:0050811
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	CYP3A7 CYP11B1 CYP3A43 CYP11B2	1.40e-03	194	50	4	GO:0016705
GeneOntologyMolecularFunction	cyclase activity	GUCY1A2 GUCY1B1	1.64e-03	24	50	2	GO:0009975
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	GUCY1A2 GUCY1B1	1.78e-03	25	50	2	GO:0016849
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	PLCL2 GDPD2 PLCL1	1.85e-03	97	50	3	GO:0008081
GeneOntologyMolecularFunction	phosphatidylinositol phospholipase C activity	PLCL2 PLCL1	1.92e-03	26	50	2	GO:0004435
GeneOntologyMolecularFunction	phospholipase C activity	PLCL2 PLCL1	2.39e-03	29	50	2	GO:0004629
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	PLCL2 GDPD2 PLCL1 PGP TNS1	2.73e-03	386	50	5	GO:0042578
GeneOntologyMolecularFunction	phospholipase activity	PLA2G3 PLCL2 PLCL1	2.92e-03	114	50	3	GO:0004620
GeneOntologyMolecularFunction	aromatase activity	CYP3A7 CYP3A43	3.47e-03	35	50	2	GO:0070330
GeneOntologyMolecularFunction	steroid binding	CYP11B1 CYP3A43 CYP11B2	4.51e-03	133	50	3	GO:0005496
GeneOntologyMolecularFunction	lipase activity	PLA2G3 PLCL2 PLCL1	4.99e-03	138	50	3	GO:0016298
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP3A7 CYP3A43	6.70e-03	49	50	2	GO:0016712
GeneOntologyBiologicalProcess	regulation of blood volume by renal aldosterone	CYP11B1 CYP11B2	3.44e-05	4	50	2	GO:0002017
GeneOntologyCellularComponent	guanylate cyclase complex, soluble	GUCY1A2 GUCY1B1	3.22e-05	4	49	2	GO:0008074
HumanPheno	Secretory adrenocortical adenoma	CYP11B1 CYP11B2	1.80e-05	3	13	2	HP:0011746
HumanPheno	Dexamethasone-suppressible primary hyperaldosteronism	CYP11B1 CYP11B2	5.99e-05	5	13	2	HP:0011739
HumanPheno	Elevated serum 11-deoxycortisol	CYP11B1 CYP11B2	2.14e-04	9	13	2	HP:0025436
HumanPheno	Adrenocortical adenoma	CYP11B1 CYP11B2	2.14e-04	9	13	2	HP:0008256
HumanPheno	Primary hyperaldosteronism	CYP11B1 CYP11B2	2.67e-04	10	13	2	HP:0011736
MousePheno	abnormal urine progesterone level	CYP11B1 CYP11B2	6.82e-06	2	37	2	MP:0011545
MousePheno	abnormal urine deoxycorticosterone level	CYP11B1 CYP11B2	6.82e-06	2	37	2	MP:0011552
MousePheno	decreased urine corticosterone level	CYP11B1 CYP11B2	6.82e-06	2	37	2	MP:0011550
MousePheno	increased urine deoxycorticosterone level	CYP11B1 CYP11B2	6.82e-06	2	37	2	MP:0011553
MousePheno	increased urine progesterone level	CYP11B1 CYP11B2	6.82e-06	2	37	2	MP:0011546
MousePheno	abnormal adrenal gland zona glomerulosa morphology	CYP11B1 CYP11B2	4.08e-05	4	37	2	MP:0008293
MousePheno	decreased urine aldosterone level	CYP11B1 CYP11B2	4.08e-05	4	37	2	MP:0011541
MousePheno	abnormal urine aldosterone level	CYP11B1 CYP11B2	4.08e-05	4	37	2	MP:0011539
MousePheno	abnormal urine corticosterone level	CYP11B1 CYP11B2	4.08e-05	4	37	2	MP:0011548
MousePheno	decreased urine hormone level	CYP11B1 CYP11B2	4.08e-05	4	37	2	MP:0014459
MousePheno	increased adrenal gland zona fasciculata size	CYP11B1 CYP11B2	6.78e-05	5	37	2	MP:0014286
MousePheno	uterus adenomyosis	CYP11B1 CYP11B2	1.02e-04	6	37	2	MP:0009221
MousePheno	increased urine hormone level	CYP11B1 CYP11B2	1.02e-04	6	37	2	MP:0014458
MousePheno	adrenal gland hyperplasia	CYP11B1 CYP11B2	1.02e-04	6	37	2	MP:0009078
MousePheno	abnormal urine hormone level	CYP11B1 CYP11B2	1.42e-04	7	37	2	MP:0011538
MousePheno	pituitary gland hyperplasia	CYP11B1 CYP11B2	1.42e-04	7	37	2	MP:0000635
MousePheno	increased circulating angiotensin II level	CYP11B1 CYP11B2	1.89e-04	8	37	2	MP:0031232
MousePheno	increased angiotensin II level	CYP11B1 CYP11B2	1.89e-04	8	37	2	MP:0031229
MousePheno	decreased circulating renin level	CYP11B1 CYP11B2	3.03e-04	10	37	2	MP:0003353
MousePheno	abnormal adrenocortical cell morphology	CYP11B1 CYP11B2	3.03e-04	10	37	2	MP:0008291
MousePheno	abnormal adrenal gland zona fasciculata size	CYP11B1 CYP11B2	3.69e-04	11	37	2	MP:0014284
MousePheno	uterus cyst	CYP11B1 CYP11B2	3.69e-04	11	37	2	MP:0009082
MousePheno	abnormal circulating angiotensin II level	CYP11B1 CYP11B2	4.42e-04	12	37	2	MP:0031230
MousePheno	abnormal angiotensin II level	CYP11B1 CYP11B2	4.42e-04	12	37	2	MP:0031227
MousePheno	hypokalemia	CYP11B1 CYP11B2	4.42e-04	12	37	2	MP:0004119
MousePheno	enlarged pituitary gland	CYP11B1 CYP11B2	4.42e-04	12	37	2	MP:0000636
MousePheno	peritoneal inflammation	GUCY1B1 NFKB1	4.42e-04	12	37	2	MP:0003303
MousePheno	increased renin activity	CYP11B1 CYP11B2	6.08e-04	14	37	2	MP:0005582
MousePheno	decreased circulating mineralocorticoid level	CYP11B1 CYP11B2	6.08e-04	14	37	2	MP:0003374
MousePheno	increased urine osmolality	CYP11B1 CYP11B2	6.08e-04	14	37	2	MP:0008055
MousePheno	abnormal circulating interleukin-2 level	NFKB1 ITGAL	6.08e-04	14	37	2	MP:0008598
MousePheno	increased circulating adrenocorticotropin level	CYP11B1 CYP11B2	6.08e-04	14	37	2	MP:0001748
MousePheno	decreased circulating aldosterone level	CYP11B1 CYP11B2	6.08e-04	14	37	2	MP:0002667
MousePheno	endometrium hyperplasia	CYP11B1 CYP11B2	6.08e-04	14	37	2	MP:0009092
MousePheno	increased systemic arterial systolic blood pressure	GUCY1B1 CYP11B1 CYP11B2	8.98e-04	72	37	3	MP:0006144
MousePheno	duplex kidney	SLIT2 CYFIP2	1.13e-03	19	37	2	MP:0004017
MousePheno	abnormal adrenal gland zona fasciculata morphology	CYP11B1 CYP11B2	1.13e-03	19	37	2	MP:0008294
MousePheno	abnormal renin activity	CYP11B1 CYP11B2	1.26e-03	20	37	2	MP:0005581
Domain	Cyt_P450_mitochondrial	CYP11B1 CYP11B2	7.31e-06	2	51	2	IPR002399
Domain	Cyt_P450_CS	CYP3A7 CYP11B1 CYP3A43 CYP11B2	1.31e-05	53	51	4	IPR017972
Domain	CYTOCHROME_P450	CYP3A7 CYP11B1 CYP3A43 CYP11B2	1.75e-05	57	51	4	PS00086
Domain	p450	CYP3A7 CYP11B1 CYP3A43 CYP11B2	1.88e-05	58	51	4	PF00067
Domain	Cyt_P450	CYP3A7 CYP11B1 CYP3A43 CYP11B2	2.15e-05	60	51	4	IPR001128
Domain	-	PLCL2 GDPD2 PLCL1	4.23e-05	25	51	3	3.20.20.190
Domain	PLC-like_Pdiesterase_TIM-brl	PLCL2 GDPD2 PLCL1	4.23e-05	25	51	3	IPR017946
Domain	HNOB	GUCY1A2 GUCY1B1	4.37e-05	4	51	2	PF07700
Domain	Cyt_P450_E_grp-II	CYP3A7 CYP3A43	7.27e-05	5	51	2	IPR002402
Domain	Cyt_P450_E_CYP3A	CYP3A7 CYP3A43	1.09e-04	6	51	2	IPR008072
Domain	HNOB_dom_associated	GUCY1A2 GUCY1B1	1.09e-04	6	51	2	IPR011645
Domain	HNOBA	GUCY1A2 GUCY1B1	1.09e-04	6	51	2	PF07701
Domain	PH_12	PLCL2 PLCL1	1.09e-04	6	51	2	PF16457
Domain	NO_sig/Golgi_transp_ligand-bd	GUCY1A2 GUCY1B1	2.03e-04	8	51	2	IPR024096
Domain	Heme_NO-bd	GUCY1A2 GUCY1B1	2.60e-04	9	51	2	IPR011644
Domain	-	CYP11B1 CYP3A43 CYP11B2	5.32e-04	58	51	3	1.10.630.10
Domain	PLipase_C_Pinositol-sp_Y	PLCL2 PLCL1	7.50e-04	15	51	2	IPR001711
Domain	EF-hand_like	PLCL2 PLCL1	7.50e-04	15	51	2	PF09279
Domain	PIPLC_Y_DOMAIN	PLCL2 PLCL1	7.50e-04	15	51	2	PS50008
Domain	PI-PLC_fam	PLCL2 PLCL1	7.50e-04	15	51	2	IPR001192
Domain	PLC_EF-hand-like	PLCL2 PLCL1	7.50e-04	15	51	2	IPR015359
Domain	PI-PLC-Y	PLCL2 PLCL1	7.50e-04	15	51	2	PF00387
Domain	PLCYc	PLCL2 PLCL1	7.50e-04	15	51	2	SM00149
Domain	A/G_cyclase_CS	GUCY1A2 GUCY1B1	9.68e-04	17	51	2	IPR018297
Domain	Nucleotide_cyclase	GUCY1A2 GUCY1B1	1.09e-03	18	51	2	IPR029787
Domain	PI-PLC-X	PLCL2 PLCL1	1.09e-03	18	51	2	PF00388
Domain	PLCXc	PLCL2 PLCL1	1.09e-03	18	51	2	SM00148
Domain	-	GUCY1A2 GUCY1B1	1.09e-03	18	51	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	GUCY1A2 GUCY1B1	1.21e-03	19	51	2	PS00452
Domain	Guanylate_cyc	GUCY1A2 GUCY1B1	1.21e-03	19	51	2	PF00211
Domain	PIPLC_X_DOMAIN	PLCL2 PLCL1	1.21e-03	19	51	2	PS50007
Domain	GUANYLATE_CYCLASE_2	GUCY1A2 GUCY1B1	1.21e-03	19	51	2	PS50125
Domain	PLipase_C_PInositol-sp_X_dom	PLCL2 PLCL1	1.21e-03	19	51	2	IPR000909
Domain	A/G_cyclase	GUCY1A2 GUCY1B1	1.21e-03	19	51	2	IPR001054
Domain	CYCc	GUCY1A2 GUCY1B1	1.21e-03	19	51	2	SM00044
Domain	EGF_1	SLIT2 ADAM19 PAMR1 NTN5	5.13e-03	255	51	4	PS00022
Domain	EGF_2	SLIT2 ADAM19 PAMR1 NTN5	5.87e-03	265	51	4	PS01186
Domain	Keratin_I	KRT4 KRT16	6.43e-03	44	51	2	IPR002957
Domain	Cyt_P450_E_grp-I	CYP3A7 CYP3A43	6.71e-03	45	51	2	IPR002401
Domain	HEAT	SF3B1 ECPAS	7.61e-03	48	51	2	PF02985
Pathway	KEGG_STEROID_HORMONE_BIOSYNTHESIS	CYP3A7 CYP11B1 CYP3A43 CYP11B2	6.88e-06	55	32	4	M14933
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP3A7 CYP11B1 CYP3A43 CYP11B2	1.11e-05	62	32	4	M39653
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP3A7 CYP11B1 CYP3A43 CYP11B2	1.26e-05	64	32	4	M5650
Pathway	KEGG_LINOLEIC_ACID_METABOLISM	CYP3A7 CYP3A43 PLA2G3	3.73e-05	29	32	3	M2920
Pathway	KEGG_MEDICUS_REFERENCE_STEROID_HORMONE_BIOSYNTHESIS_PROGESTERONE_TO_CORTISOL_CORTISONE	CYP11B1 CYP11B2	4.97e-05	5	32	2	M47522
Pathway	WP_ANTIVIRAL_AND_ANTIINFLAMMATORY_EFFECTS_OF_NRF2_ON_SARSCOV2_PATHWAY	GUCY1A2 GUCY1B1 NFKB1	5.04e-05	32	32	3	M42560
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	CYP3A7 CYP11B1 CYP3A43 CYP11B2	8.58e-05	104	32	4	M738
Pathway	WP_NOCGMPPKG_MEDIATED_NEUROPROTECTION	GUCY1A2 GUCY1B1 NFKB1	1.61e-04	47	32	3	M39531
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	2.22e-04	10	32	2	M27076
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	2.71e-04	11	32	2	MM14750
Pathway	WP_MAPK_AND_NFKB_SIGNALING_INHIBITED_BY_YERSINIA_YOPJ	NFKB1 MAP3K1	3.25e-04	12	32	2	M39552
Pathway	REACTOME_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	3.25e-04	12	32	2	MM14749
Pathway	BIOCARTA_CTL_PATHWAY	GZMB ITGAL	3.83e-04	13	32	2	M1462
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP11B1 CYP3A43 CYP11B2	4.41e-04	66	32	3	MM14839
Pathway	BIOCARTA_CD40_PATHWAY	NFKB1 MAP3K1	4.47e-04	14	32	2	MM1362
Pathway	WP_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	4.47e-04	14	32	2	M46449
Pathway	WP_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	4.47e-04	14	32	2	M46453
Pathway	BIOCARTA_CD40_PATHWAY	NFKB1 MAP3K1	5.15e-04	15	32	2	M16697
Pathway	BIOCARTA_RACC_PATHWAY	GUCY1A2 GUCY1B1	5.15e-04	15	32	2	M22002
Pathway	KEGG_LONG_TERM_DEPRESSION	GUCY1A2 GUCY1B1 PLA2G3	5.25e-04	70	32	3	M8232
Pathway	WP_CLASSICAL_PATHWAY_OF_STEROIDOGENESIS_WITH_GLUCOCORTICOID_AND_MINERALOCORTICOID_METABOLISM	CYP11B1 CYP11B2	5.87e-04	16	32	2	M39815
Pathway	BIOCARTA_TNFR2_PATHWAY	NFKB1 MAP3K1	6.65e-04	17	32	2	M10082
Pathway	BIOCARTA_TNFR2_PATHWAY	NFKB1 MAP3K1	6.65e-04	17	32	2	MM1517
Pathway	BIOCARTA_HCMV_PATHWAY	NFKB1 MAP3K1	6.65e-04	17	32	2	M8353
Pathway	BIOCARTA_HCMV_PATHWAY	NFKB1 MAP3K1	6.65e-04	17	32	2	MM1408
Pathway	WP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II	CYP3A7 CYP11B1 CYP3A43 CYP11B2	7.44e-04	183	32	4	M39588
Pathway	BIOCARTA_41BB_PATHWAY	NFKB1 MAP3K1	7.47e-04	18	32	2	M2064
Pathway	BIOCARTA_41BB_PATHWAY	NFKB1 MAP3K1	7.47e-04	18	32	2	MM1511
Pathway	WP_APOPTOSIS_MODULATION_BY_HSP70	NFKB1 MAP3K1	7.47e-04	18	32	2	MM15964
Pathway	WP_APOPTOSIS_MODULATION_BY_HSP70	NFKB1 MAP3K1	8.33e-04	19	32	2	M39450
Pathway	WP_APOPTOSIS	NFKB1 GZMB MAP3K1	8.63e-04	83	32	3	MM15972
Pathway	BIOCARTA_CTL_PATHWAY	GZMB ITGAL	9.25e-04	20	32	2	MM1374
Pathway	BIOCARTA_CERAMIDE_PATHWAY	NFKB1 MAP3K1	1.02e-03	21	32	2	M19943
Pathway	BIOCARTA_NFKB_PATHWAY	NFKB1 MAP3K1	1.02e-03	21	32	2	MM1444
Pathway	BIOCARTA_NFKB_PATHWAY	NFKB1 MAP3K1	1.02e-03	21	32	2	M15285
Pathway	WP_APOPTOSIS	NFKB1 GZMB MAP3K1	1.02e-03	88	32	3	M39654
Pathway	WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES	NFKB1 MAP3K1	1.12e-03	22	32	2	M39773
Pathway	REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE	GUCY1A2 GUCY1B1	1.12e-03	22	32	2	M915
Pathway	REACTOME_XENOBIOTICS	CYP3A7 CYP3A43	1.23e-03	23	32	2	M5372
Pathway	BIOCARTA_CERAMIDE_PATHWAY	NFKB1 MAP3K1	1.23e-03	23	32	2	MM1367
Pathway	WP_FGF23_SIGNALING_IN_HYPOPHOSPHATEMIC_RICKETS_AND_RELATED_DISORDERS	CYP11B2 NFKB1	1.23e-03	23	32	2	M39862
Pathway	WP_SILDENAFIL_TREATMENT	GUCY1A2 GUCY1B1	1.23e-03	23	32	2	M46455
Pathway	BIOCARTA_TOLL_PATHWAY	NFKB1 MAP3K1	1.34e-03	24	32	2	MM1518
Pathway	BIOCARTA_STRESS_PATHWAY	NFKB1 MAP3K1	1.34e-03	24	32	2	MM1515
Pathway	BIOCARTA_STRESS_PATHWAY	NFKB1 MAP3K1	1.34e-03	24	32	2	M9670
Pathway	REACTOME_ENDOGENOUS_STEROLS	CYP11B1 CYP11B2	1.45e-03	25	32	2	M11184
Pathway	BIOCARTA_VIP_PATHWAY	NFKB1 MAP3K1	1.45e-03	25	32	2	MM1441
Pathway	REACTOME_TRAF6_MEDIATED_NF_KB_ACTIVATION	NFKB1 MAP3K1	1.45e-03	25	32	2	M940
Pathway	BIOCARTA_TOLL_PATHWAY	NFKB1 MAP3K1	1.45e-03	25	32	2	M984
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	CYP3A7 CYP11B1 CYP3A43 CYP11B2	1.47e-03	220	32	4	M10320
Pathway	BIOCARTA_VIP_PATHWAY	NFKB1 MAP3K1	1.57e-03	26	32	2	M17941
Pathway	REACTOME_ENDOGENOUS_STEROLS	CYP11B1 CYP11B2	1.69e-03	27	32	2	MM14844
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	CYP11B1 CYP3A43 CYP11B2	1.70e-03	105	32	3	MM14842
Pathway	WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES	CYP3A7 CYP11B1 CYP11B2	2.00e-03	111	32	3	M48065
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	GUCY1A2 GUCY1B1 PLA2G3	2.21e-03	115	32	3	M9387
Pathway	BIOCARTA_IL1R_PATHWAY	NFKB1 MAP3K1	2.23e-03	31	32	2	M12095
Pathway	PID_AVB3_OPN_PATHWAY	NFKB1 MAP3K1	2.23e-03	31	32	2	M63
Pathway	PID_CD40_PATHWAY	NFKB1 MAP3K1	2.23e-03	31	32	2	M45
Pathway	WP_SIGNAL_TRANSDUCTION_THROUGH_IL1R	NFKB1 MAP3K1	2.52e-03	33	32	2	M39803
Pathway	BIOCARTA_FMLP_PATHWAY	NFKB1 MAP3K1	2.68e-03	34	32	2	M10287
Pathway	BIOCARTA_FMLP_PATHWAY	NFKB1 MAP3K1	2.68e-03	34	32	2	MM1399
Pathway	REACTOME_METABOLIC_DISORDERS_OF_BIOLOGICAL_OXIDATION_ENZYMES	CYP11B1 CYP11B2	2.68e-03	34	32	2	M27461
Pathway	REACTOME_SMOOTH_MUSCLE_CONTRACTION	GUCY1A2 GUCY1B1	2.83e-03	35	32	2	MM15114
Pathway	KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	NFKB1 PRDM4 MAP3K1	2.86e-03	126	32	3	M16763
Pathway	REACTOME_METABOLISM_OF_STEROID_HORMONES	CYP11B1 CYP11B2	3.00e-03	36	32	2	M27081
Pathway	WP_OXIDATIVE_DAMAGE_RESPONSE	NFKB1 MAP3K1	3.69e-03	40	32	2	M39340
Pathway	WP_PDGF_PATHWAY	NFKB1 MAP3K1	3.69e-03	40	32	2	M39555
Pathway	REACTOME_METABOLISM_OF_STEROID_HORMONES	CYP11B1 CYP11B2	3.87e-03	41	32	2	MM14757
Pathway	BIOCARTA_IL1R_PATHWAY	NFKB1 MAP3K1	3.87e-03	41	32	2	MM1493
Pathway	BIOCARTA_TCR_PATHWAY	NFKB1 MAP3K1	4.06e-03	42	32	2	MM1504
Pathway	WP_OXIDATIVE_DAMAGE_RESPONSE	NFKB1 MAP3K1	4.06e-03	42	32	2	MM15945
Pathway	WP_BRAINDERIVED_NEUROTROPHIC_FACTOR_BDNF_SIGNALING	YBX1 NFKB1 MAP3K1	4.17e-03	144	32	3	M39691
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP11B1 CYP11B2	4.25e-03	43	32	2	MM15873
Pathway	REACTOME_SMOOTH_MUSCLE_CONTRACTION	GUCY1A2 GUCY1B1	4.25e-03	43	32	2	M1429
Pathway	BIOCARTA_TCR_PATHWAY	NFKB1 MAP3K1	4.45e-03	44	32	2	M19784
Pathway	PID_CERAMIDE_PATHWAY	NFKB1 MAP3K1	4.45e-03	44	32	2	M144
Pubmed	Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.	CYP11B1 CYP11B2	2.11e-06	2	51	2	17651452
Pubmed	Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.	CYP11B1 CYP11B2	2.11e-06	2	51	2	23150505
Pubmed	Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.	CYP11B1 CYP11B2	2.11e-06	2	51	2	34743356
Pubmed	GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	2.11e-06	2	51	2	35012455
Pubmed	Role of genetic variation in regulation of aldosterone biosynthesis.	CYP11B1 CYP11B2	2.11e-06	2	51	2	21164264
Pubmed	Structural and functional insights into the heme-binding domain of the human soluble guanylate cyclase α2 subunit and heterodimeric α2β1.	GUCY1A2 GUCY1B1	2.11e-06	2	51	2	22426988
Pubmed	Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.	CYP11B1 CYP11B2	2.11e-06	2	51	2	20339375
Pubmed	Phospholipase C-related but catalytically inactive protein acts as a positive regulator of insulin signalling in adipocytes.	PLCL2 PLCL1	2.11e-06	2	51	2	34859819
Pubmed	Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	2.11e-06	2	51	2	20808686
Pubmed	The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.	CYP11B1 CYP11B2	2.11e-06	2	51	2	8645611
Pubmed	Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice.	PLCL2 PLCL1	2.11e-06	2	51	2	31589911
Pubmed	Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.	CYP11B1 CYP11B2	2.11e-06	2	51	2	12231255
Pubmed	A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.	CYP11B1 CYP11B2	2.11e-06	2	51	2	20634641
Pubmed	Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.	CYP11B1 CYP11B2	2.11e-06	2	51	2	1303253
Pubmed	Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.	CYP11B1 CYP11B2	2.11e-06	2	51	2	21519965
Pubmed	Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface.	PLCL2 PLCL1	2.11e-06	2	51	2	17301177
Pubmed	Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.	CYP11B1 CYP11B2	2.11e-06	2	51	2	21625068
Pubmed	Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.	CYP11B1 CYP11B2	2.11e-06	2	51	2	16110193
Pubmed	Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.	CYP11B1 CYP11B2	2.11e-06	2	51	2	26066897
Pubmed	Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels.	PLCL2 PLCL1	2.11e-06	2	51	2	19553601
Pubmed	Genetic reduction of GABA(A) receptor gamma2 subunit expression potentiates the immobilizing action of isoflurane.	PLCL2 PLCL1	2.11e-06	2	51	2	20097266
Pubmed	Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.	CYP11B1 CYP11B2	2.11e-06	2	51	2	1741400
Pubmed	Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.	CYP11B1 CYP11B2	2.11e-06	2	51	2	32540969
Pubmed	Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.	CYP11B1 CYP11B2	2.11e-06	2	51	2	26047574
Pubmed	Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.	CYP11B1 CYP11B2	2.11e-06	2	51	2	26324851
Pubmed	Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.	CYP11B1 CYP11B2	2.11e-06	2	51	2	18651133
Pubmed	Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.	CYP11B1 CYP11B2	2.11e-06	2	51	2	7669222
Pubmed	A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.	CYP11B1 CYP11B2	2.11e-06	2	51	2	22083159
Pubmed	Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.	CYP11B1 CYP11B2	2.11e-06	2	51	2	22933298
Pubmed	Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	2.11e-06	2	51	2	2783417
Pubmed	Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.	CYP11B1 CYP11B2	2.11e-06	2	51	2	2256920
Pubmed	Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.	CYP11B1 CYP11B2	2.11e-06	2	51	2	15699546
Pubmed	Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex.	PLCL2 PLCL1	2.11e-06	2	51	2	17254016
Pubmed	Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors.	PLCL2 PLCL1	2.11e-06	2	51	2	19996098
Pubmed	Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.	CYP11B1 CYP11B2	2.11e-06	2	51	2	18162527
Pubmed	Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.	CYP11B1 CYP11B2	2.11e-06	2	51	2	38341019
Pubmed	Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.	CYP11B1 CYP11B2	2.11e-06	2	51	2	20708777
Pubmed	Molecular genetic studies on the biosynthesis of aldosterone in humans.	CYP11B1 CYP11B2	2.11e-06	2	51	2	22217843
Pubmed	Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.	CYP11B1 CYP11B2	2.11e-06	2	51	2	16396990
Pubmed	Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.	CYP11B1 CYP11B2	2.11e-06	2	51	2	24837548
Pubmed	Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.	CYP11B1 CYP11B2	2.11e-06	2	51	2	30046010
Pubmed	Familial and phenotypic associations of the aldosterone Renin ratio.	CYP11B1 CYP11B2	2.11e-06	2	51	2	19820005
Pubmed	Novel Serine 176 Phosphorylation of YBX1 Activates NF-κB in Colon Cancer.	YBX1 NFKB1	2.11e-06	2	51	2	28077578
Pubmed	[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.	CYP11B1 CYP11B2	2.11e-06	2	51	2	18397978
Pubmed	Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.	CYP11B1 CYP11B2	2.11e-06	2	51	2	1518866
Pubmed	Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.	CYP11B1 CYP11B2	2.11e-06	2	51	2	22622494
Pubmed	Identification and characterization of a new phospholipase C-like protein, PLC-L(2).	PLCL2 PLCL1	2.11e-06	2	51	2	10581172
Pubmed	Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.	CYP11B1 CYP11B2	2.11e-06	2	51	2	15062555
Pubmed	Procollagen I-expressing renin cell precursors.	CYP11B1 CYP11B2	2.11e-06	2	51	2	23761669
Pubmed	Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.	CYP11B1 CYP11B2	2.11e-06	2	51	2	17075030
Pubmed	Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.	CYP11B1 CYP11B2	2.11e-06	2	51	2	17075029
Pubmed	Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).	CYP11B1 CYP11B2	2.11e-06	2	51	2	2592361
Pubmed	CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.	CYP11B1 CYP11B2	2.11e-06	2	51	2	15507509
Pubmed	Polymorphism of CYP11B2 determines salt sensitivity in Japanese.	CYP11B1 CYP11B2	2.11e-06	2	51	2	17296872
Pubmed	Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.	CYP11B1 CYP11B2	2.11e-06	2	51	2	23314847
Pubmed	Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.	CYP11B1 CYP11B2	2.11e-06	2	51	2	17980006
Pubmed	Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.	CYP11B1 CYP11B2	2.11e-06	2	51	2	16984984
Pubmed	Evidence for local aldosterone synthesis in the large intestine of the mouse.	CYP11B1 CYP11B2	2.11e-06	2	51	2	35288482
Pubmed	Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.	CYP11B1 CYP11B2	2.11e-06	2	51	2	15731365
Pubmed	Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.	CYP11B1 CYP11B2	2.11e-06	2	51	2	18039983
Pubmed	Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.	CYP11B1 CYP11B2	2.11e-06	2	51	2	19029289
Pubmed	Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.	CYP11B1 CYP11B2	2.11e-06	2	51	2	15522937
Pubmed	Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.	CYP3A7 CYP11B1 CYP3A43 CYP11B2	3.50e-06	70	51	4	15128046
Pubmed	Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.	CYP11B1 CYP11B2	6.32e-06	3	51	2	36861295
Pubmed	Phospholipase C-related but catalytically inactive protein modulates pain behavior in a neuropathic pain model in mice.	PLCL2 PLCL1	6.32e-06	3	51	2	23639135
Pubmed	Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.	CYP11B1 CYP11B2	6.32e-06	3	51	2	36778748
Pubmed	Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.	CYP11B1 CYP11B2	6.32e-06	3	51	2	8111631
Pubmed	The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.	CYP11B1 CYP11B2	6.32e-06	3	51	2	2546938
Pubmed	Kidney function in mice lacking aldosterone.	CYP11B1 CYP11B2	6.32e-06	3	51	2	16118390
Pubmed	Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells.	CYP11B1 CYP11B2	6.32e-06	3	51	2	10411633
Pubmed	Differential effects of high and low steroidogenic factor-1 expression on CYP11B2 expression and aldosterone production in adrenocortical cells.	CYP11B1 CYP11B2	6.32e-06	3	51	2	18974272
Pubmed	Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells.	CYP11B1 CYP11B2	6.32e-06	3	51	2	17984374
Pubmed	Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids.	CYP11B1 CYP11B2	6.32e-06	3	51	2	1686470
Pubmed	PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines.	NFKB1 PGP	6.32e-06	3	51	2	18640717
Pubmed	Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	6.32e-06	3	51	2	2233742
Pubmed	Substrate-induced modulation of protein-protein interactions within human mitochondrial cytochrome P450-dependent system.	CYP11B1 CYP11B2	6.32e-06	3	51	2	33271253
Pubmed	Mislocalization of protein kinase A drives pathology in Cushing's syndrome.	CYP11B1 CYP11B2	6.32e-06	3	51	2	35830806
Pubmed	The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene.	CYP11B1 CYP11B2	6.32e-06	3	51	2	18801336
Pubmed	Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1.	CYP11B1 CYP11B2	6.32e-06	3	51	2	11932209
Pubmed	Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation.	GUCY1A2 GUCY1B1	6.32e-06	3	51	2	17610859
Pubmed	Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption.	CYP11B1 CYP11B2	6.32e-06	3	51	2	21467193
Pubmed	Identification of NF-κB and PLCL2 as new susceptibility genes and highlights on a potential role of IRF8 through interferon signature modulation in systemic sclerosis.	NFKB1 PLCL2	6.32e-06	3	51	2	25880423
Pubmed	Phospholipase C-related catalytically inactive protein, a novel microtubule-associated protein 1 light chain 3-binding protein, negatively regulates autophagosome formation.	PLCL2 PLCL1	6.32e-06	3	51	2	23399561
Pubmed	Control of renin secretion from kidneys with renin cell hyperplasia.	CYP11B1 CYP11B2	6.32e-06	3	51	2	24285498
Pubmed	Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase.	PLCL2 PLCL1	6.32e-06	3	51	2	24945349
Pubmed	Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.	CYP11B1 CYP11B2	6.32e-06	3	51	2	7750493
Pubmed	Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.	CYP11B1 CYP11B2	6.32e-06	3	51	2	26471128
Pubmed	Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.	CYP11B1 CYP11B2	6.32e-06	3	51	2	28355486
Pubmed	Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by β-Adrenergic Receptors in Brown Adipocytes.	PLCL2 PLCL1	6.32e-06	3	51	2	26706316
Pubmed	Involvement of PRIP, phospholipase C-related, but catalytically inactive protein, in bone formation.	PLCL2 PLCL1	6.32e-06	3	51	2	21757756
Pubmed	Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes.	CYP11B1 CYP11B2	6.32e-06	3	51	2	32245948
Pubmed	Zona Glomerulosa-Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice.	CYP11B1 CYP11B2	1.26e-05	4	51	2	38573585
Pubmed	Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis.	CYP11B1 CYP11B2	1.26e-05	4	51	2	38301271
Pubmed	Crosstalk between androgen receptor and WNT/β-catenin signaling causes sex-specific adrenocortical hyperplasia in mice.	CYP11B1 CYP11B2	1.26e-05	4	51	2	37102205
Pubmed	Familial varieties of primary aldosteronism.	CYP11B1 CYP11B2	1.26e-05	4	51	2	11903322
Pubmed	Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor.	CYP11B1 CYP11B2	1.26e-05	4	51	2	19342457
Pubmed	Cutting Edge: De Novo Glucocorticoid Synthesis by Thymic Epithelial Cells Regulates Antigen-Specific Thymocyte Selection.	CYP11B1 CYP11B2	1.26e-05	4	51	2	29440508
Pubmed	Phospholipase C-related, but catalytically inactive protein (PRIP) up-regulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling.	PLCL2 PLCL1	1.26e-05	4	51	2	28341745
Pubmed	The aldo-keto reductase AKR1B7 coexpresses with renin without influencing renin production and secretion.	CYP11B1 CYP11B2	1.26e-05	4	51	2	23303406
Pubmed	Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus.	CYP11B1 CYP11B2	1.26e-05	4	51	2	30917317
Cytoband	5q33.3	ADAM19 CYFIP2	7.44e-04	36	51	2	5q33.3
Cytoband	5q11.2	DHX29 MAP3K1	1.55e-03	52	51	2	5q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr5q11	DHX29 MAP3K1	5.06e-03	95	51	2	chr5q11
GeneFamily	Cytochrome P450 family 11	CYP11B1 CYP11B2	9.09e-06	3	32	2	1007
GeneFamily	Guanylate cyclases, soluble	GUCY1A2 GUCY1B1	1.82e-05	4	32	2	820
GeneFamily	Cytochrome P450 family 3	CYP3A7 CYP3A43	8.44e-05	8	32	2	1002
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCL2 PLCL1	5.09e-04	19	32	2	832
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GUCY1A2 GUCY1B1 TMEM131L RIPOR3 PLCL1 TNS1	5.29e-08	177	51	6	a8625d14682183cf77cb51eaf11bc15a3528f586
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GUCY1A2 GUCY1B1 TMEM131L RIPOR3 PLCL1 TNS1	5.29e-08	177	51	6	3645e2f4a48283f290f85c49c3e79e3f58ac9aa6
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLIT2 GUCY1A2 GUCY1B1 TMEM131L PLCL1 TNS1	8.06e-08	190	51	6	5681c211baeed4af82a2bbc13420f6a7b487581c
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Hematologic-hematopoietic_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM19 PAMR1 GZMB TNS1 CYFIP2	1.86e-06	178	51	5	d9eba884e18a0c89bdc70c194bfe4d62cca164fa
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Hematologic-hematopoietic_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM19 PAMR1 GZMB TNS1 CYFIP2	1.86e-06	178	51	5	b03aa1de9d20895ebad55f6fcd6fe7a49335db5a
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Hematologic\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM19 PAMR1 GZMB TNS1 CYFIP2	1.86e-06	178	51	5	0f5cf34609df791c8baebfdc6590f6eb4dbe0509
ToppCell	COVID-19-Heart-EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GUCY1A2 GUCY1B1 RIPOR3 PLCL1 PGM5	2.07e-06	182	51	5	e67f3234165199085c793915ebb1f9bbd845e933
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC SLIT2 PAMR1 TNS1 PGM5	2.49e-06	189	51	5	32e6d6285b258831b965281224ff2aaeecdcb5f5
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC SLIT2 PAMR1 TNS1 PGM5	2.49e-06	189	51	5	385ef7bbd76c8047aeecf6542377d4213b5da5db
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLIT2 ADAM19 GUCY1A2 TMEM131L PGM5	2.56e-06	190	51	5	562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLIT2 ADAM19 GUCY1A2 TMEM131L PGM5	2.56e-06	190	51	5	f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCell	Adult-Immune-T_lymphocyte-D175\|Adult / Lineage, Cell type, age group and donor	ADAM19 PLCL2 TMEM131L ITGAL CYFIP2	2.62e-06	191	51	5	0b84fd1dc68146d9f72422b102744d2847f5ecb2
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell\|Adult / Lineage, Cell type, age group and donor	BOC SLIT2 GUCY1A2 PAMR1 RIPOR3	2.69e-06	192	51	5	d21f0f577156f17c899b08871046a26b88aea011
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_only / Treatment groups by lineage, cell group, cell type	SLIT2 GUCY1A2 GUCY1B1 DTX3 PLCL1	3.28e-06	200	51	5	69edc375d85689300d1dbc1217fedc40063ecdcb
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-FB-2\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	FZD9 SLIT2 IGSF1 TNS1	1.28e-05	125	51	4	6cd741dd1c7ee6b16437cca7c15c99b5c95603fc
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-Natural_Killer\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GZMB ADGRB2 EMP3 CYFIP2	3.14e-05	157	51	4	071f10d749b590b75a07ab3c7b00956dc7cda4da
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GZMB ADGRB2 EMP3 CYFIP2	3.14e-05	157	51	4	af110085dad5d26b0b7068a78f104ba784fa8564
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GZMB ADGRB2 ITGAL CYFIP2	3.22e-05	158	51	4	8844fba9c1e41f062edf3110d025f33b86afb951
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-Natural_Killer\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GZMB ADGRB2 ITGAL CYFIP2	3.22e-05	158	51	4	c56607cba9a3719ac6d573d970686053e1676985
ToppCell	facs-Lung-18m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GZMB ADGRB2 ITGAL CYFIP2	3.38e-05	160	51	4	e4516b093003275084fc327d1597394a436754eb
ToppCell	facs-Lung-18m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GZMB ADGRB2 ITGAL CYFIP2	3.38e-05	160	51	4	0a507e3d59d7f744d0201a531ea84fa97a68aedb
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADAM19 GZMB ITGAL CYFIP2	3.55e-05	162	51	4	af9999e5fcd28ff1f401d52fd220315752c40027
ToppCell	facs-Lung-18m-Hematologic-Lymphocytic_NK_ILC\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GZMB ADGRB2 ITGAL CYFIP2	3.55e-05	162	51	4	04ccd3d216f8f41afd3434a61264f03d6324db35
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SLIT2 MYO15B TNS1 MAP3K1	3.90e-05	166	51	4	f62db9d9b6c9dd8f2afcaea0fc5f8c69f50205b2
ToppCell	Control-B_cells-Activated_B_cells\|Control / group, cell type (main and fine annotations)	ADAM19 PLCL2 TMEM131L CYFIP2	4.09e-05	168	51	4	a7159a35fe37f8c241cf8d391debe271e0698105
ToppCell	facs-Heart-LV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	4.58e-05	173	51	4	d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCell	facs-Heart-LV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	4.58e-05	173	51	4	3c852ffe22f4a5b632463086b08c669310684e80
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GUCY1A2 GUCY1B1 PLA2G3 PLCL1	4.79e-05	175	51	4	2a53d4f140d5ab096efe8118d8aa351db7838b49
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GUCY1A2 GUCY1B1 PLA2G3 PLCL1	4.79e-05	175	51	4	fb91a45763e4c48d993094a13088ffc19f1e2574
ToppCell	facs-GAT-Fat-3m-Lymphocytic\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GZMB ITGAL MAP3K1 CYFIP2	4.90e-05	176	51	4	2e3f25a338842384517656d05776a52cbfc62b52
ToppCell	facs-GAT-Fat-3m-Lymphocytic-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GZMB ITGAL MAP3K1 CYFIP2	4.90e-05	176	51	4	0823088bc6b19c7ad784d83c2ccdfae80611afab
ToppCell	Control-B_cells-B_cells\|Control / group, cell type (main and fine annotations)	ADAM19 TMEM131L MAP3K1 CYFIP2	4.90e-05	176	51	4	d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCell	droplet-Lung-nan-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	5.01e-05	177	51	4	65709bd546cb1ec6aa2ddd8b2adb46e174eb9a9a
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	5.01e-05	177	51	4	8684d47a547e2a06496f15e8da0200ecddc431e0
ToppCell	facs-Lung-nan-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 PLA2G3 PLCL1	5.23e-05	179	51	4	7078022e60faa86444f2a2c6eb9f767cc66b5cfa
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLIT2 EMP3 TNS1 PGM5	5.23e-05	179	51	4	b559f5a72cc9e3e35d05cb539b5c2e006e56e652
ToppCell	facs-Lung-nan-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 PLA2G3 PLCL1	5.23e-05	179	51	4	d4a975d8ffa5e77fb5c0ec05bf9c8f843c77ce07
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BOC SLIT2 PAMR1 GUCY1B1	5.46e-05	181	51	4	e1ae9ada60ec89e7a7cde9c231c1a099ed2ffecc
ToppCell	COVID-19-Heart-Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GUCY1A2 GUCY1B1 RIPOR3 PLCL1	5.46e-05	181	51	4	33cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCell	facs-Heart-LV-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	5.46e-05	181	51	4	1db1eb7d330a7e5090994007ae287e11f0a74450
ToppCell	facs-Heart-LV-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	5.46e-05	181	51	4	06174ce9240c9261c0f51a1b0d875335d60722e5
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B-B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADAM19 MYCBP2 TMEM131L CYFIP2	5.46e-05	181	51	4	8d8cc4dae2c8bd5f4b1c159f2a52edc4c9449c86
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BOC SLIT2 GUCY1B1 PLCL1	5.58e-05	182	51	4	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLIT2 GUCY1A2 GUCY1B1 PLCL1	5.70e-05	183	51	4	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	facs-Heart-RA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	5.70e-05	183	51	4	0f02136359787bd78146617990968baa47a65d86
ToppCell	LV-07._Pericyte\|World / Chamber and Cluster_Paper	GUCY1A2 GUCY1B1 DTX3 RIPOR3	5.70e-05	183	51	4	273db6a3b00a93ca852498471187b642b5368185
ToppCell	COVID-19_Mild-NK_activated\|COVID-19_Mild / Disease condition and Cell class	GZMB TMEM131L ECPAS ITGAL	5.70e-05	183	51	4	22bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCell	facs-Heart-RA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	5.70e-05	183	51	4	2f0dcc65ad4d90ef946919b4462280fdd20c5ea0
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLIT2 GUCY1A2 GUCY1B1 PLCL1	5.82e-05	184	51	4	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	facs-Skin-Skin_Anagen-18m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHKA1 SLIT2 GUCY1A2 PAMR1	5.82e-05	184	51	4	fea4fe648e9749177d0783443dc26a7df5807883
ToppCell	facs-Heart-RV-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	5.82e-05	184	51	4	9c20b50f8d6ac689d41d5440c835f9db8d04758b
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BOC SLIT2 PAMR1 PGM5	5.82e-05	184	51	4	e33e2a887aafba7b6a31f00bb0dbe974b4359fd6
ToppCell	COVID-19-Heart-Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	GUCY1A2 GUCY1B1 RIPOR3 PLCL1	5.82e-05	184	51	4	21790cdfa3b4036ad413fd44b94e31563116f25f
ToppCell	facs-Heart-RV-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	5.82e-05	184	51	4	31dbe6119a3bcd266ae5e9b340c853d9ff680dce
ToppCell	facs-Skin-Skin_Anagen-18m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHKA1 SLIT2 GUCY1A2 PAMR1	5.82e-05	184	51	4	96a8a0a190bc293655fe7d80cbed8119c0da25f2
ToppCell	facs-Skin-Skin_Anagen-18m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHKA1 SLIT2 GUCY1A2 PAMR1	5.82e-05	184	51	4	780eb72da43527f0c72effac3423ec7384f05f20
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D231\|Adult / Lineage, Cell type, age group and donor	BOC SLIT2 GUCY1A2 PAMR1	5.95e-05	185	51	4	fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell	COVID-19-Fibroblasts-Adventitial_FB\|COVID-19 / group, cell type (main and fine annotations)	BOC SLIT2 PAMR1 RIPOR3	5.95e-05	185	51	4	a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCell	LA-07._Pericyte\|LA / Chamber and Cluster_Paper	GUCY1A2 GUCY1B1 RIPOR3 PLCL1	5.95e-05	185	51	4	ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT4 SF3B1 KRT16 NFKB1	5.95e-05	185	51	4	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	Control-T_cells-NK_cells\|Control / group, cell type (main and fine annotations)	GZMB PLCL2 ITGAL CYFIP2	5.95e-05	185	51	4	755c0998c729f462399f1d5e88adf4bfae31be30
ToppCell	LV-07._Pericyte\|LV / Chamber and Cluster_Paper	GUCY1A2 GUCY1B1 DTX3 RIPOR3	5.95e-05	185	51	4	acb38eba871ec72f2a8136a33b87d33b8c85465d
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	SLIT2 GUCY1A2 GUCY1B1 PLCL1	6.07e-05	186	51	4	cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCell	RV-07._Pericyte\|RV / Chamber and Cluster_Paper	GUCY1A2 GUCY1B1 DTX3 RIPOR3	6.07e-05	186	51	4	c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCell	facs-Heart-LA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	6.20e-05	187	51	4	a12f383b02b07af32cc53a154685df8dba8fbd3f
ToppCell	facs-Heart-LA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	6.20e-05	187	51	4	c40c152fa14e6afc9188549534b64ccbaded56b3
ToppCell	IPF-Myeloid-DC_Mature\|IPF / Disease state, Lineage and Cell class	ADAM19 TMEM131L RIPOR3 PLCL1	6.20e-05	187	51	4	63e0304a0183b69aebb0d1a4640a506a0d6fb6e9
ToppCell	droplet-Skin-nan-21m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLCL2 ADGRB2 EMP3 ITGAL	6.20e-05	187	51	4	38d7b19fde6811f5fbf548b2464486b197476dc6
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GUCY1A2 GUCY1B1 TMEM131L RIPOR3	6.20e-05	187	51	4	ec4b694487cc446999c7b27b119950a4f252c4b3
ToppCell	RV-07._Pericyte\|World / Chamber and Cluster_Paper	GUCY1A2 GUCY1B1 DTX3 RIPOR3	6.20e-05	187	51	4	dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCell	droplet-Skin-nan-21m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLCL2 ADGRB2 EMP3 ITGAL	6.20e-05	187	51	4	ea33a5bd60b7f5f6d5b07a7f06a5a56395943641
ToppCell	Control-T_cells\|Control / group, cell type (main and fine annotations)	ADAM19 PLCL2 ITGAL CYFIP2	6.20e-05	187	51	4	f4e8e0eba58da89b56587667555a5d4754e108c7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GUCY1A2 GUCY1B1 TMEM131L RIPOR3	6.20e-05	187	51	4	530e4e6d91b5c0d9aa4543caa2b734a1674c5788
ToppCell	droplet-Skin-nan-21m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLCL2 ADGRB2 EMP3 ITGAL	6.20e-05	187	51	4	1dbc2c0ab85033e5de776bbfdb73ebd3a50d2cc6
ToppCell	E16.5-samps-Mesenchymal\|E16.5-samps / Age Group, Lineage, Cell class and subclass	BOC SLIT2 EMP3 TNS1	6.33e-05	188	51	4	3f0f662be684e3a4c6652e636cc135a39a1d2790
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD9 GUCY1B1 ADGRB2 PGM5	6.46e-05	189	51	4	4dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD9 GUCY1B1 ADGRB2 PGM5	6.46e-05	189	51	4	0d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM19 GZMB EMP3 ITGAL	6.46e-05	189	51	4	43d8264b763ef6c82368c1d67d63ff0a25861c45
ToppCell	COVID-19-T_cells-NK_cells\|COVID-19 / group, cell type (main and fine annotations)	GZMB PLCL2 ITGAL CYFIP2	6.46e-05	189	51	4	b699152dfbb8cd8ed724e1e5a51838f29b681b62
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLIT2 ADAM19 GUCY1A2 PAMR1	6.59e-05	190	51	4	2e88e366d377d74deb53a4ea870973ce5c6532e8
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 TNS1	6.59e-05	190	51	4	1d8e169d2448a34180c415843bb49aa45ed540c5
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D175\|Adult / Lineage, Cell type, age group and donor	BOC SLIT2 GUCY1A2 RIPOR3	6.59e-05	190	51	4	7dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCell	facs-Heart-RA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	6.59e-05	190	51	4	bfbdf16d488359d7935a419c4c1823288f39c183
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLIT2 ADAM19 GUCY1A2 PAMR1	6.59e-05	190	51	4	0028f886c789ba238c031eae5d96acaed4af8c25
ToppCell	facs-Heart-RA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	6.59e-05	190	51	4	eb1f8bb4d903b08e50c2dc173b06c0c79d8e316e
ToppCell	Control-T_cells-CD4+_T_cells\|Control / group, cell type (main and fine annotations)	ADAM19 PLCL2 ITGAL CYFIP2	6.59e-05	190	51	4	0733be5e54fe15d6d6ea51c154a95258e83f1b92
ToppCell	Fetal_29-31_weeks-Immune-B_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAM19 PLCL2 TMEM131L CYFIP2	6.59e-05	190	51	4	424550418c1bd4eb070cf3c41cf09fa9d89aef37
ToppCell	Fetal_29-31_weeks-Immune-B_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAM19 PLCL2 TMEM131L CYFIP2	6.73e-05	191	51	4	84452125d1b5b76974e3f9126f611eff16d45c25
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	6.73e-05	191	51	4	5c1f5b6c115b1b27b4a7467a6550ce43c01cf6d0
ToppCell	ASK440-Mesenchymal\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	BOC SLIT2 GUCY1A2 PAMR1	6.73e-05	191	51	4	f12959eebb4167e1aa03de05d7711a702c58b3c9
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GZMB PLCL2 ITGAL CYFIP2	6.73e-05	191	51	4	9b8b64a36e27a2523b8730c7922fd7ad865a021e
ToppCell	ASK440-Mesenchymal-Fibroblast\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	BOC SLIT2 GUCY1A2 PAMR1	6.73e-05	191	51	4	387296b5377ef6839f0812e5b3529a10b5f7d530
ToppCell	B_cells-Memory_B_cells\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ADAM19 TMEM131L MAP3K1 CYFIP2	6.87e-05	192	51	4	eef591095921ede098f41a2b81897b18915bb753
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	6.87e-05	192	51	4	eb9a0b3d32f90f8b95905c740aab21639dae5cbd
ToppCell	NS-moderate-d_07-13-Lymphoid\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ADAM19 GZMB ITGAL CYFIP2	6.87e-05	192	51	4	bd4059bfc2159f5ed8bbb2a5408b56117ca6f8e1
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GZMB PLCL2 ITGAL CYFIP2	7.01e-05	193	51	4	1cb666375bc4e1b11a146d20896c9b5ae6fd0887
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADAM19 GZMB ITGAL CYFIP2	7.01e-05	193	51	4	00349d176fb6a46cbcc99c41d975651b6e9aaad4
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ADAM19 MYCBP2 PRDM4 MAP3K1	7.15e-05	194	51	4	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCY1A2 GUCY1B1 DTX3 PLCL1	7.15e-05	194	51	4	b8a130ffae68ffe550bf335460a1ec1035cf8d8d
ToppCell	Monocytes-Inflammatory_CD16+_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	GUCY1B1 EMP3 ITGAL CYFIP2	7.15e-05	194	51	4	28d19105123b015f8aa25ea8e6c078f630d4ba80
Drug	Cortodoxone	CYP11B1 CYP11B2 NFKB1	3.68e-07	7	51	3	ctd:D003350
Drug	lansoprazole	BOC CYP3A7 CYP11B1 CYP3A43 CYP11B2	2.07e-06	93	51	5	CID000003883
Drug	Sparteinum	BOC CYP3A7 CYP11B1 CYP3A43 CYP11B2	3.11e-06	101	51	5	CID000003966
Drug	cyadox	CYP11B1 CYP11B2	4.92e-06	2	51	2	ctd:C020728
Drug	18-hydroxydeoxycorticosterone	CYP11B1 CYP11B2	4.92e-06	2	51	2	ctd:C042509
Drug	chloral hydrate	BOC CYP3A7 CYP11B1 CYP3A43 CYP11B2	1.03e-05	129	51	5	CID000002707
Drug	aminoglutethimide	CYP3A7 CYP11B1 CYP3A43 CYP11B2 ITGAL	1.38e-05	137	51	5	CID000002145
Drug	18-hydroxycortisol	CYP11B1 CYP11B2	1.47e-05	3	51	2	ctd:C033689
Drug	propoxyphene	CYP3A7 CYP11B1 CYP3A43 CYP11B2	1.54e-05	67	51	4	CID000010100
Drug	carteolol	CYP3A7 CYP11B1 CYP3A43 CYP11B2	2.05e-05	72	51	4	CID000002583
Drug	C05489	CYP11B1 CYP11B2	2.94e-05	4	51	2	CID000440708
Drug	trimipramine	CYP3A7 CYP11B1 CYP3A43 CYP11B2	3.11e-05	80	51	4	CID000005584
Drug	paraoxon	CYP3A7 CYP11B1 CYP3A43 CYP11B2 PLA2G3	3.28e-05	164	51	5	CID000009395
Drug	S-nitrosoacetylcysteine	GUCY1A2 GUCY1B1 NFKB1	3.71e-05	29	51	3	CID000122058
Drug	diosmetin	CYP3A7 CYP11B1 CYP3A43 CYP11B2	3.95e-05	85	51	4	CID005281612
Drug	mephenytoin	CYP3A7 CYP11B1 CYP3A43 CYP11B2	4.53e-05	88	51	4	CID000004060
Drug	17alpha, 21-dihydroxypregnenolone	CYP11B1 CYP11B2	4.90e-05	5	51	2	CID000192735
Drug	walrycin A	CYP11B1 CYP11B2 GZMB	5.02e-05	32	51	3	ctd:C574123
Drug	Guanosine Triphosphate	GUCY1A2 GUCY1B1 PGP	5.51e-05	33	51	3	ctd:D006160
Drug	tienilic acid	CYP3A7 CYP11B1 CYP3A43 CYP11B2	5.63e-05	93	51	4	CID000038409
Drug	pentanal	TCF19 CYP11B2 NFKB1 PRDM4	6.37e-05	96	51	4	CID000008063
Drug	alprazolam	CYP3A7 CYP11B1 CYP3A43 CYP11B2 NFKB1	7.11e-05	193	51	5	CID000002118
Drug	Tetrahydronaphthalenes	CYP11B1 CYP11B2	7.34e-05	6	51	2	ctd:D013764
Drug	Methandrostenolone	CYP11B1 CYP11B2	7.34e-05	6	51	2	ctd:D008696
Drug	AC1L1KIN	CYP3A7 CYP11B1 CYP3A43 CYP11B2	7.47e-05	100	51	4	CID000005516
Drug	Doxylamine succinate [562-10-7]; Up 200; 10.2uM; PC3; HT_HG-U133A	GUCY1B1 PLCL2 PGP TNS1 AGBL3	8.03e-05	198	51	5	4235_UP
Drug	Aminophylline [317-34-0]; Up 200; 9.6uM; PC3; HT_HG-U133A	KRT4 PLCL2 TMEM131L GDPD2 ECPAS	8.22e-05	199	51	5	6295_UP
Drug	diclofenac	CYP3A7 CYP11B1 CYP3A43 CYP11B2 EMP3	1.04e-04	209	51	5	CID000003032
Drug	Aroclor 1254	CYP3A7 GUCY1B1 CYP3A43 NFKB1 EMP3	1.13e-04	213	51	5	CID000040470
Drug	dioxin	CYP3A7 CYP11B1 CYP3A43 CYP11B2 NFKB1 PGP	1.21e-04	347	51	6	CID000015625
Drug	2,2',3,3',4,6'-hexachlorobiphenyl	CYP11B1 CYP11B2	1.37e-04	8	51	2	ctd:C094859
Drug	1,3-dibromopropane	BOC NDUFAF3	1.37e-04	8	51	2	CID000008001
Drug	AC1Q7AUJ	CYP3A7 CYP11B1 CYP3A43 CYP11B2	1.37e-04	117	51	4	CID000003303
Drug	8-MOP	CYP3A7 CYP11B1 CYP3A43 CYP11B2	1.42e-04	118	51	4	CID000004114
Drug	benzo(a)pyrene	CYP3A7 CYP3A43 CYP11B2 NFKB1 HPS5 MAP3K1	1.44e-04	358	51	6	CID000002336
Drug	enniatins	CYP11B1 CYP11B2 MAP3K1	1.71e-04	48	51	3	ctd:C100264
Drug	GKT137831	CYP11B1 CYP11B2	1.75e-04	9	51	2	ctd:C576694
Drug	2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine	CYP11B1 ITGAL	1.75e-04	9	51	2	ctd:C104564
Drug	AK13	TCF19 PRDM4	1.75e-04	9	51	2	CID001091543
Drug	2,2',3,4',5',6-hexachlorobiphenyl	CYP11B1 CYP11B2	1.75e-04	9	51	2	ctd:C120129
Drug	hexobarbital	CYP3A7 CYP11B1 CYP3A43 CYP11B2	1.88e-04	127	51	4	CID000003608
Drug	2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide	BOC GUCY1A2 GUCY1B1	2.17e-04	52	51	3	CID011776156
Drug	Indans	CYP11B1 CYP11B2	2.19e-04	10	51	2	ctd:D007189
Drug	perflubron	CYP11B1 CYP11B2	2.19e-04	10	51	2	ctd:C003072
Disease	adrenal cortical adenoma (is_marker_for)	CYP11B1 CYP11B2	2.48e-06	2	47	2	DOID:0050891 (is_marker_for)
Disease	Glucocorticoid-remediable aldosteronism	CYP11B1 CYP11B2	2.48e-06	2	47	2	C1260386
Disease	congenital adrenal hyperplasia (implicated_via_orthology)	CYP11B1 CYP11B2	7.44e-06	3	47	2	DOID:0050811 (implicated_via_orthology)
Disease	brain infarction (biomarker_via_orthology)	CYP11B1 CYP11B2 GZMB	2.00e-05	33	47	3	DOID:3454 (biomarker_via_orthology)
Disease	primary hyperaldosteronism (is_implicated_in)	CYP11B1 CYP11B2	2.48e-05	5	47	2	DOID:446 (is_implicated_in)
Disease	forced expiratory volume	BOC FZD9 CYP3A7 ADAM19 PLCL1 TNS1 MAP3K1 CYFIP2	3.15e-05	789	47	8	EFO_0004314
Disease	Conn Syndrome	CYP11B1 CYP11B2	3.71e-05	6	47	2	C1384514
Disease	Hyperaldosteronism	CYP11B1 CYP11B2	3.71e-05	6	47	2	C0020428
Disease	protocadherin alpha-7 measurement	CYP11B1 CYP11B2	5.19e-05	7	47	2	EFO_0801973
Disease	T-cell immunoglobulin and mucin domain 1 measurement	ADAM19 CYFIP2	5.19e-05	7	47	2	EFO_0010812
Disease	protein FAM163B measurement	CYP11B1 CYP11B2	8.88e-05	9	47	2	EFO_0802936
Disease	androstenedione measurement	CYP11B1 CYP11B2	1.11e-04	10	47	2	EFO_0007972
Disease	3-hydroxyanthranilate 3,4-dioxygenase measurement	CYP11B1 CYP11B2	1.35e-04	11	47	2	EFO_0021862
Disease	cell growth regulator with EF hand domain protein 1 measurement	CYP11B1 CYP11B2	1.35e-04	11	47	2	EFO_0801461
Disease	dermatomyositis	CYP11B1 PLCL1	1.62e-04	12	47	2	EFO_0000398
Disease	metabolonic lactone sulfate measurement	CYP3A7 CYP3A43	4.17e-04	19	47	2	EFO_0800659
Disease	age at voice drop	IGSF1 ECPAS	5.62e-04	22	47	2	EFO_0007888
Disease	C-reactive protein measurement	FZD9 CYP3A7 ADAM19 NFKB1 RIPOR3 MAP3K1 CYFIP2 PGM5	5.78e-04	1206	47	8	EFO_0004458
Disease	apolipoprotein L1 measurement	CYP11B1 CYP11B2	7.28e-04	25	47	2	EFO_0021854
Disease	epiandrosterone sulfate measurement	CYP3A7 CYP3A43	7.28e-04	25	47	2	EFO_0021120
Disease	psoriasis	ADAM19 TCF19 NFKB1 PLCL2	9.35e-04	273	47	4	EFO_0000676
Disease	puberty onset measurement	PLCL1 ECPAS CYFIP2	1.05e-03	125	47	3	EFO_0005677
Disease	cortical surface area measurement	FZD9 SLIT2 SF3B1 MYCBP2 NFKB1 PLCL1 TNS1 MAP3K1	1.18e-03	1345	47	8	EFO_0010736
Disease	allergic rhinitis	BOC NFKB1 PLCL1	1.26e-03	133	47	3	EFO_0005854
Disease	membranous glomerulonephritis	TCF19 NFKB1	1.27e-03	33	47	2	EFO_0004254
Disease	Mammary Carcinoma, Human	GUCY1A2 YBX1 DTX3 GZMB MAP3K1	1.45e-03	525	47	5	C4704874
Disease	Mammary Neoplasms, Human	GUCY1A2 YBX1 DTX3 GZMB MAP3K1	1.45e-03	525	47	5	C1257931
Disease	Malignant neoplasm of breast	BOC GUCY1A2 YBX1 DTX3 GZMB TNS1 MAP3K1	1.46e-03	1074	47	7	C0006142
Disease	Mammary Neoplasms	GUCY1A2 YBX1 DTX3 GZMB MAP3K1	1.47e-03	527	47	5	C1458155
Disease	hippocampal CA3 volume	SLIT2 MAP3K1	1.51e-03	36	47	2	EFO_0009395

Protein segments in the cluster

Peptide	Gene	Start	Entry
ANPVYMCGEGGLRQL	ADGRB2	1321	O60241
PMLNPDGVIVGNYRC	AGBL3	401	Q8NEM8
MYQPSRGAARRLGPC	C6orf136	1	Q5SQH8
NMPDTRMLYGGRRCG	ADAM19	406	Q9H013
IVSYGRNNGMPPRAC	GZMB	216	P10144
GPGGRNSLCGYQIRM	DHX29	651	Q7Z478
LGLAYGAPCMRLSNQ	CBY3	116	A6NI87
NLSCIPYFRQMGVRG	PGM5	321	Q15124
DALRLGPNGGLLYCM	GPN2	71	Q9H9Y4
LGCNNRMKLSGRPYR	PHKA1	486	P46020
GQQPLIYCARPGSRM	HPS5	231	Q9UPZ3
MIARQQCVRGGPRGF	KRT4	1	P19013
QQLLAGVGGLPVMYC	ECPAS	661	Q5VYK3
RYLQQPGCLLVGTNM	PGP	186	A6NDG6
GRYCMQLSQIQGLIG	KRT16	366	P08779
RAPGMRQIYGRQGGN	GDPD2	401	Q9HCC8
GVIGQRMPRYCLFGN	GUCY1B1	531	Q02153
GGTQGRRGCRSLLYM	CYFIP2	571	Q96F07
RDYCVLGAGPAGLQM	FOXRED2	31	Q8IWF2
MGAYLVRQGQCRPGL	MYO15B	536	Q96JP2
MCRGIGYNLTRMPNL	FZD9	46	O00144
MCGRFYGQLVGNQPQ	DTX3	201	Q8N9I9
GESLNLRCQGPIYGM	IGSF1	241	Q8N6C5
VGRYQCVARMPAGAV	BOC	101	Q9BWV1
RYIPFGAGPRNCIGM	CYP3A43	431	Q9HB55
GAGPRNCIGMRFALT	CYP3A43	436	Q9HB55
VPFGFGMRQCLGRRL	CYP11B1	441	P15538
GPIFRYNLGGPRMVC	CYP11B2	76	P19099
VPFGFGMRQCLGRRL	CYP11B2	441	P19099
MRRGGLFYATGLCQL	EMP3	91	P54852
GSGPRNCIGMRFALV	CYP3A7	436	P24462
IGDRGVMCGLPERNY	PRDM4	76	Q9UKN5
YGGDCMRCGQVLRAP	PAMR1	121	Q6UXH9
VVGVRMPRYCLFGNN	GUCY1A2	626	P33402
MAPEVLRGQQYGRSC	MAP3K1	1416	Q13233
MAGLRRPQPGCYCRT	TMEM131L	1	A2VDJ0
NRCGPGYQQSRSPRM	NTN5	306	Q8WTR8
NGNCGYVLRPAIMRE	PLCL2	721	Q9UPR0
MRQAHPGCGRYAGGQ	MYCBP2	3256	O75592
SGLCYLFRQNLQGPM	ITGAL	126	P20701
GCRMYGTVPLARLQP	PLA2G3	261	Q9NZ20
GMQTLGLQHRCRGGY	RITA1	11	Q96K30
MLPCFQLLRIGGGRG	TCF19	1	Q9Y242
AGLQPLCAYRVLGRM	PNMA5	41	Q96PV4
LQNGGCGYVLRPSIM	PLCL1	686	Q15111
AGEQGRPVRQNMYRG	YBX1	226	P67809
RGFMINGNRVLGPCA	NDUFAF3	66	Q9BU61
IRMKGLVGYARLCPG	RIPOR3	206	Q96MK2
GLRVAIGPCRMLQYC	SF3B1	1236	O75533
GGCRPFLRIYQAMQP	TNS1	201	Q9HBL0
QRPRVGLYTQCMGPS	SLIT2	226	O94813
YDPRGNRLVCMACGR	ZFTA	276	C9JLR9
RMTEACIRGYNPGLL	NFKB1	156	P19838