Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	gamma-tubulin ring complex	BRCA1 NEDD1	2.04e-04	11	41	2	GO:0000931
Domain	Znf_C2H2-like	ZBTB12 ZNF385B ZNF101 ZNF556 ZNF670 ZNF665 ZNF541 ZNF292 ZNF667	5.57e-05	796	42	9	IPR015880
Domain	Znf_C2H2	ZBTB12 ZNF385B ZNF101 ZNF556 ZNF670 ZNF665 ZNF541 ZNF292 ZNF667	6.08e-05	805	42	9	IPR007087
Domain	ZnF_C2H2	ZBTB12 ZNF385B ZNF101 ZNF556 ZNF670 ZNF665 ZNF541 ZNF292 ZNF667	6.25e-05	808	42	9	SM00355
Domain	-	ZBTB12 ZNF101 ZNF556 ZNF670 ZNF665 ZNF541 ZNF292 ZNF667	1.16e-04	679	42	8	3.30.160.60
Domain	zf-C2H2	ZBTB12 ZNF101 ZNF556 ZNF670 ZNF665 ZNF541 ZNF292 ZNF667	1.33e-04	693	42	8	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZBTB12 ZNF101 ZNF556 ZNF670 ZNF665 ZNF541 ZNF292 ZNF667	1.34e-04	694	42	8	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZBTB12 ZNF101 ZNF556 ZNF670 ZNF665 ZNF541 ZNF292 ZNF667	2.86e-04	775	42	8	PS50157
Domain	ZINC_FINGER_C2H2_1	ZBTB12 ZNF101 ZNF556 ZNF670 ZNF665 ZNF541 ZNF292 ZNF667	2.91e-04	777	42	8	PS00028
Domain	SPRR/LCE	SPRR4 PRR9	1.80e-03	28	42	2	IPR026075
Domain	RING	RNF13 CHD4 BRCA1 DTX3	4.79e-03	305	42	4	SM00184
Domain	zf-C2H2_6	ZNF556 ZNF670 ZNF541 ZNF667	5.31e-03	314	42	4	PF13912
Domain	Znf_RING	RNF13 CHD4 BRCA1 DTX3	6.05e-03	326	42	4	IPR001841
Domain	Znf_C3HC4_RING-type	RNF13 BRCA1 DTX3	6.77e-03	172	42	3	IPR018957
Domain	KRAB	ZNF101 ZNF556 ZNF670 ZNF667	8.37e-03	358	42	4	PS50805
Domain	KRAB	ZNF101 ZNF556 ZNF670 ZNF667	8.37e-03	358	42	4	PF01352
Domain	ZF_DAG_PE_1	RACGAP1 TNS2	9.11e-03	64	42	2	PS00479
Domain	ZF_DAG_PE_2	RACGAP1 TNS2	9.11e-03	64	42	2	PS50081
Domain	KRAB	ZNF101 ZNF556 ZNF670 ZNF667	9.29e-03	369	42	4	SM00349
Domain	KRAB	ZNF101 ZNF556 ZNF670 ZNF667	9.37e-03	370	42	4	IPR001909
Domain	C1	RACGAP1 TNS2	9.39e-03	65	42	2	SM00109
Domain	PE/DAG-bd	RACGAP1 TNS2	9.67e-03	66	42	2	IPR002219
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	FAM76B ZMYM2 XRN2 CHD4 BRCA1 NEDD1 MARS1 NUP153 ZNF292 EIF5	5.78e-07	1103	42	10	34189442
Pubmed	RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells.	XRN2 BRCA1	4.27e-06	3	42	2	37697435
Pubmed	Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events.	BRCA1 NUP153	8.53e-06	4	42	2	28751496
Pubmed	Centralspindlin assembly and 2 phosphorylations on MgcRacGAP by Polo-like kinase 1 initiate Ect2 binding in early cytokinesis.	RACGAP1 BRCA1	8.53e-06	4	42	2	25486482
Pubmed	FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.	RACGAP1 XRN2 CHD4 MARS1 NUP153	1.21e-05	248	42	5	27926873
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	FAM76B ZMYM2 RACGAP1 XRN2 CHD4 BRCA1 NUP153 EIF5	1.61e-05	954	42	8	36373674
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF101 ZNF670 ZNF665	2.90e-05	49	42	3	9630514
Pubmed	Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression.	CHD4 BRCA1	2.98e-05	7	42	2	23011797
Pubmed	BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage.	XRN2 BRCA1	5.10e-05	9	42	2	34112789
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	ZMYM2 RACGAP1 XRN2 CHD4 BRCA1	5.40e-05	339	42	5	30415952
Pubmed	Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome.	MARS1 NUP153 EIF5	7.43e-05	67	42	3	29357390
Pubmed	Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.	BRCA1 NUP153	9.32e-05	12	42	2	28700933
Pubmed	Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.	ZMYM2 CHD4 ZNF292	1.00e-04	74	42	3	29795351
Pubmed	LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer.	CHD4 BRCA1	1.10e-04	13	42	2	19703393
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ZMYM2 CHD4 NEDD1 MARS1 NUP153 ZNF667 EIF5	1.17e-04	934	42	7	33916271
Pubmed	NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.	CHD4 BRCA1	1.28e-04	14	42	2	25150861
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	ZMYM2 RACGAP1 ZBTB12 BRCA1	1.50e-04	222	42	4	37071664
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	CHD4 ZNF101 BRCA1 DTX3 ZNF292 EIF5	1.97e-04	709	42	6	22988430
Pubmed	A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.	ZMYM2 CHD4	2.15e-04	18	42	2	12493763
Pubmed	Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.	BRCA1 NUP153	2.40e-04	19	42	2	14578343
Pubmed	Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.	BRCA1 NOBOX	2.40e-04	19	42	2	21478856
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	FAM76B ZMYM2 RACGAP1 XRN2 ZNF541 EIF5	2.67e-04	750	42	6	11230166
Pubmed	Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds.	PTN CHD4	2.95e-04	21	42	2	12124942
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	ZMYM2 XRN2 CHD4 NUP153	3.20e-04	271	42	4	32433965
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	RACGAP1 TNS2 NUP153	3.97e-04	118	42	3	30979931
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	GRM7 NUP153 ZNF292	4.48e-04	123	42	3	26912792
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	ZMYM2 ZBTB12 CHD4	4.70e-04	125	42	3	32891193
Pubmed	Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.	RACGAP1 CHD4 NEDD1 PIP4P2	6.05e-04	321	42	4	32098917
Pubmed	Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex.	PTN CHD4	6.06e-04	30	42	2	18055048
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	ZMYM2 CHD4 BRCA1	7.38e-04	146	42	3	23892456
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	ZMYM2 CHD4 BRCA1	7.98e-04	150	42	3	28242625
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZMYM2 RACGAP1 CHD4 BRCA1 ZNF292	8.01e-04	608	42	5	36089195
Pubmed	A protein interaction framework for human mRNA degradation.	XRN2 CHD4 BRCA1 ZNF330	8.08e-04	347	42	4	15231747
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	ZMYM2 XRN2 CHD4 NUP153	8.26e-04	349	42	4	25665578
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	ZMYM2 CHD4 BRCA1	8.45e-04	153	42	3	26365490
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	ZMYM2 CHD4 BRCA1 NUP153	8.98e-04	357	42	4	37059091
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	ZMYM2 RACGAP1 XRN2 CHD4 MARS1 NUP153	1.14e-03	989	42	6	36424410
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	RACGAP1 TNS2 MARS1 DTX3	6.03e-04	423	42	4	chr12q13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB12 ZNF101 ZNF556 ZNF670 ZNF330 ZNF665 ZNF541 ZNF292 ZNF667	1.58e-06	718	30	9	28
GeneFamily	Ring finger proteins	RNF13 BRCA1 DTX3	1.04e-02	275	30	3	58
Disease	Abnormal muscle tone	RNF13 ZNF292	2.82e-05	6	41	2	C0852413
Disease	Feeding difficulties	RNF13 ZNF292	2.84e-04	18	41	2	C0232466
Disease	Attention deficit hyperactivity disorder	GRM7 ZNF292	5.10e-04	24	41	2	C1263846
Disease	liver cirrhosis (biomarker_via_orthology)	PTN MUC2	1.03e-03	34	41	2	DOID:5082 (biomarker_via_orthology)
Disease	colon cancer (is_marker_for)	BRCA1 MTUS1	3.07e-03	59	41	2	DOID:219 (is_marker_for)
Disease	Intellectual Disability	ZMYM2 RNF13 BRCA1 ZNF292	3.38e-03	447	41	4	C3714756
Disease	keratoconus	FAM76B MAP3K19	3.82e-03	66	41	2	MONDO_0015486
Disease	breast carcinoma (is_marker_for)	BRCA1 MTUS1	3.82e-03	66	41	2	DOID:3459 (is_marker_for)
Disease	lung cancer (is_implicated_in)	XRN2 CHD4	4.78e-03	74	41	2	DOID:1324 (is_implicated_in)
Disease	Liver carcinoma	RACGAP1 GDF2 PAMR1 MTUS1	5.28e-03	507	41	4	C2239176

Protein segments in the cluster

Peptide	Gene	Start	Entry
KLPKVKCSPFCNGEI	CMTR2	501	Q8IYT2
QVPKPCTFLCKNTKG	FBN3	2411	Q75N90
CQKTVTISKPCGKLT	PTN	131	P21246
TKVGKACCVPTKLSP	GDF2	386	Q9UK05
KQGPPEVTCQIRKKT	NOBOX	261	O60393
TEPAPGTQKKKRCQC	PALM2	361	Q8IXS6
GDKIVVSSCKCKPVP	NEDD1	56	Q8NHV4
SICQCPALVGTEKPK	MTUS1	101	Q9ULD2
GIICQPKRCSQKPVT	MUC2	4846	Q02817
ICKKCAQNVKQFGTP	FAM76B	56	Q5HYJ3
KGPSQCPLCKNDITK	BRCA1	56	P38398
CGGTCKNKVTVSKPV	DTX3	11	Q8N9I9
VNPKKQTIGNSCKAC	EIF5	111	P55010
KGITPCKPIDIKCSV	GNPAT	61	O15228
GVLKITICKSCQKPV	ARV1	51	Q9H2C2
SVCTLPCKPGQRKKT	GRM7	521	Q14831
PRCTCPALKGKVQKI	CHD4	491	Q14839
FAKPPKQVQTVCECI	DNAH10	3156	Q8IVF4
KCPIPSQCVVKKTLE	PIWIL3	601	Q7Z3Z3
KQSFPCICKNPGTQK	MAP3K19	611	Q56UN5
SGKQPICIKACREPK	PAMR1	336	Q6UXH9
VKCTVCNEATPIKNP	PIP4P2	76	Q8N4L2
KTCPVCKQKVVPSQG	RNF13	276	O43567
IQSQIKCTPIKTGPK	TGM4	646	P49221
SKTVIKPESCVPCGK	RACGAP1	291	Q9H0H5
CKCVNTDLPPKGKNN	ZNF665	51	Q9H7R5
SGSKCETKKLPPNQC	ZNF667	86	Q5HYK9
KNIKCTKCPEVFQGV	ZBTB12	331	Q9Y330
PVKCQETCAPKTKDP	SPRR4	31	Q96PI1
CAPQVKKQCPPKGTI	SPRR4	46	Q96PI1
CVEEKPKECNGVKIP	XRN2	21	Q9H0D6
VRTQIGQKPSKCEKC	ZNF556	416	Q9HAH1
TKVGQKKTPAFPPCC	HEATR9	526	A2RTY3
PKAPVQKFSCQVEGC	ZNF292	1091	O60281
CPQKVQEKCSSPGKG	PRR9	101	Q5T870
GVSIPPKKKQVISCN	ZNF385B	146	Q569K4
KCVACETPKPGTCVK	NUP153	741	P49790
QQPTKPVKVTCANCK	ZMYM2	321	Q9UBW7
PVKVTCANCKKPLQK	ZMYM2	326	Q9UBW7
QTGVKPCKCSVCGKV	ZNF101	96	Q8IZC7
VQKLPICAQCGKTKC	ZNF330	61	Q9Y3S2
KKPQCKVCRSCPVVQ	MARS1	431	P56192
KKPPVCAVCKVTIDG	TNS2	41	Q63HR2
NLNKKVSTGVKPCEC	ZNF670	91	Q9BS34
QKTKPFVCIEQGCSK	ZNF541	191	Q9H0D2