Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-25

2.42e-0737745GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-25

2.78e-0738745GO:0070001
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-8 ERVK-7

7.89e-0611743GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-8 ERVK-7

1.73e-0514743GO:0003964
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-8 ERVK-7

6.19e-0521743GO:0035613
GeneOntologyMolecularFunctionferrous iron binding

NT5E FTO PLOD1

1.85e-0430743GO:0008198
GeneOntologyMolecularFunctionvitamin binding

AGXT2 KL ACACA STRA6 PLOD1

3.29e-04161745GO:0019842
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 ERVK-8 ERVK-7

3.47e-0437743GO:0016891
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-8 ERVK-7

3.75e-0438743GO:0034061
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ERVK-6 ERVK-8 ERVK-7 FTO ARID1A CRY1

4.23e-04262746GO:0140097
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 ERVK-8 ERVK-7

6.61e-0446743GO:0016893
GeneOntologyMolecularFunctionracemase and epimerase activity, acting on carbohydrates and derivatives

RENBP DSEL

7.29e-0411742GO:0016857
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

FADS1 CYP11B2 FTO PLOD1 UTY

7.70e-04194745GO:0016705
GeneOntologyMolecularFunctionglucosidase activity

MGAM KL

1.38e-0315742GO:0015926
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

FTO PLOD1 UTY

1.81e-0365743GO:0016706
GeneOntologyMolecularFunctionracemase and epimerase activity

RENBP DSEL

1.99e-0318742GO:0016854
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-6 SELENOO ERVK-8 ERVK-7

2.46e-03152744GO:0016779
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 ERVK-8 ERVK-7

3.16e-0379743GO:0004521
GeneOntologyMolecularFunctioniron ion binding

NT5E CYP11B2 FTO PLOD1

3.37e-03166744GO:0005506
GeneOntologyMolecularFunctiontransition metal ion binding

TXNRD1 ERVK-6 HDAC6 MYCBP2 NT5E CYP11B2 ERVK-8 ERVK-19 ERVK-7 FTO PLOD1

4.21e-0311897411GO:0046914
GeneOntologyMolecularFunctiondynein complex binding

HDAC6 CNTRL

4.81e-0328742GO:0070840
GeneOntologyMolecularFunctiondioxygenase activity

FTO PLOD1 UTY

5.78e-0398743GO:0051213
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-8 ERVK-7

1.19e-0513733GO:0015074
DomainIQ

MYO1E MYO7A SCN10A

2.12e-0371673PF00612
DomainIQ_motif_EF-hand-BS

MYO1E MYO7A SCN10A

4.15e-0390673IPR000048
DomainIQ

MYO1E MYO7A SCN10A

4.55e-0393673PS50096
DomainFERM_N

MYO7A PTPN21

6.23e-0333672PF09379
DomainFERM_N

MYO7A PTPN21

6.23e-0333672IPR018979
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-19 ERVK-7

9.22e-08574312629516
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-25

1.80e-069474521542922
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-8 ERVK-19

2.01e-061274314557543
Pubmed

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

DLC1 ZNF518B FTO DNAH6 KLHL4

2.70e-0610274511214970
Pubmed

ARID1A-deficient cells require HDAC6 for progression of endometrial carcinoma.

HDAC6 ARID1A

4.47e-06274235167193
Pubmed

Clinicopathological correlation of ARID1A status with HDAC6 and its related factors in ovarian clear cell carcinoma.

HDAC6 ARID1A

4.47e-06274230787326
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

4.47e-0627429060628
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

4.47e-0627429460924
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-19

1.34e-05374210516026
Pubmed

ARID1A-mutated ovarian cancers depend on HDAC6 activity.

HDAC6 ARID1A

1.34e-05374228737768
Pubmed

Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.

KL CYP11B2

1.34e-05374226471128
Pubmed

Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis.

MYO1E SH3GL2

1.34e-05374217257598
Pubmed

Zona Glomerulosa-Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice.

KL CYP11B2

2.67e-05474238573585
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7

2.67e-05474210469592
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-19

2.67e-0547427983737
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-7

4.45e-05574211401426
Pubmed

DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.

TXNRD1 CKAP5 DNAH6

5.76e-053574324515614
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-19

6.66e-05674215063128
Pubmed

Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions.

MARK3 CKAP5

1.24e-04874222298430
Pubmed

mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle.

FADS1 ACACA

1.24e-04874220603810
Pubmed

Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene.

SH3GL2 MPDZ

1.99e-041074211978849
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-19

1.99e-041074212970426
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

TXNRD1 SNRNP48 MYO1E MYCBP2 MARK3 CNTRL URB2 PLOD1

2.01e-0475474833060197
Pubmed

Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure.

CYP11B2 RENBP

2.43e-041174220486282
Pubmed

The little elongation complex regulates small nuclear RNA transcription.

ICE1 ELL3

2.91e-041274222195968
Pubmed

Mitochondrial Raf1 Regulates Glutamine Catabolism.

MYO1E MYCBP2 MARK3 ZNF618 RENBP

3.80e-0428874538496616
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SNRNP48 HDAC6 MYO1E MYCBP2 CKAP5 ZNF521 ATP1A2 ARID1A SULT4A1 KLHL4

3.84e-041285741035914814
Pubmed

New sequence variants associated with bone mineral density.

MARK3 CKAP5

4.00e-041474219079262
Pubmed

Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.

MYO1E MYO7A

4.00e-04147428022818
Pubmed

Selenoprotein Gene Nomenclature.

TXNRD1 SELENOO

4.61e-041574227645994
Pubmed

Analysis of several hundred genetic polymorphisms may improve assessment of the individual genetic burden for coronary artery disease.

CYP11B2 RENBP

4.61e-041574212446192
Pubmed

Common body mass index-associated variants confer risk of extreme obesity.

RFTN1 FTO

4.61e-041574219553259
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

SNRNP48 ROGDI HDAC6 KIN MYCBP2 ZNF618 ZNF521 ARID1A PLOD1

4.76e-04108274938697112
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DLC1 ACACA MYCBP2 MARK3 CKAP5 MPDZ ALPK1 PTPN21

4.87e-0486174836931259
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

STK10 ACACA MYO1E MYCBP2 MYO7A USP40 ICE1 ARID1A NOD2

5.54e-04110574935748872
Pubmed

Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling.

SNRNP48 CKAP5

6.68e-041874219640993
Pubmed

Bardet-Biedl Syndrome proteins regulate cilia disassembly during tissue maturation.

HDAC6 MYO7A

7.46e-041974230446775
Pubmed

Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.

SH3GL2 SMS ATP1A2 FTO SULT4A1

8.15e-0434174529791485
Pubmed

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.

ACACA MARK3

8.28e-042074218227155
Pubmed

Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.

GALNT15 ROGDI ZNF571 RENBP STRA6 PNMA6A

8.77e-0452374611256614
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

ACACA CKAP5 MROH7 ICE1

9.25e-0420274433005030
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

HDAC6 MYCBP2 MYO7A CKAP5 RB1CC1

1.01e-0335874532460013
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

MYO1E MYCBP2 CKAP5 ICE1 DNAH6

1.05e-0336174526167880
Pubmed

Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.

GALNT15 RENBP

1.20e-032474231740596
Pubmed

Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.

MYCBP2 MARK3 ARHGAP11A

1.36e-0310274315778465
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

RFTN1 NDC1 MYCBP2 PTPN21 RB1CC1 FTO ARID1A PLOD1

1.73e-03104974827880917
Pubmed

Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.

ZNF618 TRMO

1.87e-033074220583170
Pubmed

ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis.

NT5E MEIS3

2.00e-033174236445780
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ACACA MYCBP2 CKAP5 ICE1 RB1CC1

2.00e-0341874534709266
Pubmed

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

MSR1 FADS1 ACACA CYP11B2

2.02e-0325074418660489
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

STK10 RFTN1 NDC1 ACACA MARK3

2.06e-0342174536976175
Cytoband12q23-q24.1

TXNRD1 CRY1

3.73e-05673212q23-q24.1
Cytoband15q24.1

TMEM202 STRA6

1.35e-033473215q24.1
Cytoband8p22

MSR1 DLC1

1.87e-03407328p22
GeneFamilySelenoproteins

TXNRD1 SELENOO

1.19e-0325372890
GeneFamilyRho GTPase activating proteins|BCH domain containing

DLC1 ARHGAP11A

4.69e-0350372721
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

MYO7A PTPN21

4.69e-03503721293
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

TXNRD1 STK10 RFTN1 DLC1 KIN MYCBP2 MARK3 CKAP5 SPG11 RB1CC1 FTO ARHGAP11A CRY1

2.62e-078566813M4500
CoexpressionLEIN_CHOROID_PLEXUS_MARKERS

KL FADS1 MYO7A MROH7 STRA6

7.99e-06105685M1719
CoexpressionLEIN_CHOROID_PLEXUS_MARKERS

KL FADS1 MYO7A MROH7 STRA6

9.60e-06109685MM1214
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MSR1 MGAM MEIS3 RB1CC1 ATP1A2

2.99e-061446955e948d4cb913ccd8f82262a1b4d20967aadab3ab
DrugMoroxidine hydrochloride [3160-91-6]; Down 200; 19.2uM; MCF7; HT_HG-U133A

RFTN1 HDAC6 CNTRL ALPK1 PTPN21 STRA6 SULT4A1

2.31e-061957071527_DN
Drug9 Da

MGAM ACACA SMS

4.51e-0611703CID005287565
Diseasecoronary artery disease (is_implicated_in)

AGXT2 KL FTO NOD2

8.08e-05100674DOID:3393 (is_implicated_in)
Diseasehypertension (is_implicated_in)

AGXT2 CYP11B2 ATP1A2 FTO

1.69e-04121674DOID:10763 (is_implicated_in)
Diseasehypertension (biomarker_via_orthology)

KL FADS1 HDAC6 CYP11B2 ATP1A2

1.69e-04227675DOID:10763 (biomarker_via_orthology)
Diseaselevel of Phosphatidylethanolamine (18:1_18:1) in blood serum

FADS1 MYO1E

4.54e-0414672OBA_2045142
Diseaselevel of Phosphatidylethanolamine (18:0_20:4) in blood serum

FADS1 MYO1E

8.47e-0419672OBA_2045140
Diseasealcohol use disorder (implicated_via_orthology)

FADS1 ATP1A2 ARID1A UTY

1.02e-03195674DOID:1574 (implicated_via_orthology)
DiseaseColorectal Carcinoma

TXNRD1 KL FADS1 DLC1 ACACA DSEL ARID1A

1.06e-03702677C0009402
Diseasepulse pressure measurement

FADS1 DLC1 MYO1E MARK3 ZNF618 CYP11B2 CNTRL SCN10A CKAP5 FTO

1.13e-0313926710EFO_0005763
Diseaseoptic disc size measurement

RFTN1 DLC1 MARK3 STRA6

1.23e-03205674EFO_0004832
Diseasesciatic neuropathy (implicated_via_orthology)

SCN10A FTO

1.25e-0323672DOID:11446 (implicated_via_orthology)
Diseaselysophosphatidylcholine 18:0 measurement

GALNT15 FADS1

1.36e-0324672EFO_0010359
Diseaselevel of Phosphatidylethanolamine (16:0_18:2) in blood serum

FADS1 MYO1E

1.36e-0324672OBA_2045136
Diseaseapolipoprotein L1 measurement

DLC1 CYP11B2

1.47e-0325672EFO_0021854
Diseaselevel of Phosphatidylethanolamine (18:0_18:2) in blood serum

FADS1 MYO1E

1.85e-0328672OBA_2045139
Diseaseselenium measurement

TXNRD1 ZNF521

1.98e-0329672EFO_0006331
Diseasepneumonia, COVID-19

GALNT15 ACACA SH3GL2

2.19e-03113673EFO_0003106, MONDO_0100096
DiseaseOvarian Mucinous Adenocarcinoma

RPS6KB2 ALPK1

2.26e-0331672C1335167

Protein segments in the cluster

PeptideGeneStartEntry
LFEKDHMVVGHWENR

URB2

841

Q14146
LLLHQGHMEWLFDAE

AGXT2

86

Q9BYV1
NFSQVHIMDEHWRGE

CNTRL

2221

Q7Z7A1
NESEHHWDMVRRHLQ

ERVK-19

566

O71037
NDSEHHWDMVRRHLQ

ERVK-8

566

Q902F8
REHMAQWEVRSQTHV

ELL3

181

Q9HB65
LAEEIRHMFHVAWVD

ACACA

1726

Q13085
WHHFTDVERQMTAQH

ALPK1

1076

Q96QP1
GWELMEQVESHHRGV

MROH7

931

Q68CQ1
VSGLDANWLEHMSDH

RFTN1

311

Q14699
HREHIHMNATQWETL

KIN

101

O60870
EMLHTDQRANHEGSW

ARID1A

1531

O14497
HDEHLQHQGWAAIMA

RB1CC1

141

Q8TDY2
RVVAFWMEHSHDQEH

RENBP

31

P51606
FHGDWHMDIEQANLH

KIAA0100

1136

Q14667
MAVSWHHDENLVDRS

FTO

226

Q9C0B1
ENEQLCVHHVWIMDS

HSP90AB4P

301

Q58FF6
DGVNRTQDDMHVWLA

KATNIP

1036

O60303
LGEHVHQQYRHDMNW

MGAM

266

O43451
HWDFQENGMIVHILS

GALNT15

586

Q8N3T1
DWAEMNHPFQGSHRQ

PCED1A

286

Q9H1Q7
NMWIRDHEDSGSVHL

MEIS3

201

Q99687
GWAARIIQHEMDHLQ

PDF

206

Q9HBH1
NESEHHWDMVRRHLQ

ERVK-7

1326

P63135
DEETIFHALMQWVGH

KLHL4

341

Q9C0H6
IHMNQIGFEREWHKF

PLOD1

601

Q02809
MEQWDHFHNQQEDTD

MSR1

1

P21757
PVVFRWHDIANMSHN

PTPN21

251

Q16825
VAHMWFDNQIHEADT

ATP1A2

386

P50993
KWLQDEMFHSDFQHH

CKAP5

1206

Q14008
HMRQEKEAAHQDPWS

DNAH6

3471

Q9C0G6
IGMFIQHAHDEDIPW

ICE1

2196

Q9Y2F5
NESEHHWDMVRRHLQ

ERVK-25

566

P61570
NESEHHWDMVRRHLQ

ERVK-6

566

Q69384
DAIMTQLRQEGWIHH

CRY1

341

Q16526
HIDHDRNMDWVSTQL

FADS1

346

O60427
VHGDGHAENLVQWEM

MARK3

701

P27448
QEMHVTHFRFSLDWA

KL

586

Q9UEF7
WREQGYEHLHLEMHQ

CYP11B2

56

P19099
VDWDVHHGNGTQHMF

HDAC6

646

Q9UBN7
WFDHHGNSPMASIQE

DSEL

636

Q8IZU8
AVQLDHGHAAAWMDL

UTY

341

O14607
MTEHRKVSDHIQWFN

ARHGAP11A

801

Q6P4F7
MFEWGSQRLEVSHVH

ROGDI

231

Q9GZN7
QEQGMAESVHTWQDH

SMS

31

P52788
DVQRHPFFRHMNWDD

RPS6KB2

321

Q9UBS0
AAAWQAEHVRVMHAN

SELENOO

576

Q9BVL4
ASFLWHEGIVHDAMA

MYCBP2

3036

O75592
EEHVTHWMGQPFNSD

DLC1

11

Q96QB1
QNMAAHWVFLETHDG

STRA6

486

Q9BX79
DHTTEMLHVWQGVSE

PNMA6A

176

P0CW24
NNLRHTDEMFWNHVS

NT5E

371

P21589
QHSVELWVQFSHAMD

HTR3D

416

Q70Z44
EAMGHIQDSTEDHTW

SPG11

1501

Q96JI7
HDWDRMIEAVQNHIG

TXNRD1

246

Q16881
EHSLMGLEQFSHVWI

TRMO

71

Q9BU70
HHWVQNVLSEFVMSE

ZNF618

596

Q5T7W0
HWQHMETIELVNDGS

MPDZ

251

O75970
HSHVENMLDLAWERG

NOD2

146

Q9HC29
FEHVQEFWEHRMDSN

SULT4A1

176

Q9BR01
HVRWEAGIDDMFNFQ

SCN10A

1631

Q9Y5Y9
NQIDENWYEGMLHGH

SH3GL2

321

Q99962
NEWDIQVHVANHMID

ZNF521

1206

Q96K83
HMEAEGPVDVRHVQW

TEDC1

156

Q86SX3
AALWEMEEHQLQERH

STK10

741

O94804
TLATHGLMEQHVWDV

TMEM115

61

Q12893
NLFVAQVHWHTRDAM

TMEM202

171

A6NGA9
FGWTSNEEMRQHDVQ

USP40

121

Q9NVE5
ESLQWENMGKRINHH

ZNF571

66

Q7Z3V5
NVHMEELSNHWQEEQ

SNRNP48

246

Q6IEG0
EDQEEWMSHGQRHLI

ZNF518B

1046

Q9C0D4
MFLDASHAGLVNEHW

GLYATL2

166

Q8WU03
WQSHNVKHSGVDDMV

MYO1E

11

Q12965
QRMAEAVLGTHDDWQ

MYO7A

706

Q13402
SDAQMHIWALEGLSH

NDC1

556

Q9BTX1