Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

3.83e-244314922GO:0004984
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 MRGPRE OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

1.07e-188844923GO:0004930
GeneOntologyMolecularFunctionodorant binding

OR5W2 OR5T3 OR8D1 OR8U1 OR9I1 OR8U3 OR8B2 OR8D4 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

3.21e-181274913GO:0005549
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 MRGPRE OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

1.14e-1413534923GO:0004888
GeneOntologyMolecularFunctionmetallocarboxypeptidase activity

CPA6 CPB2 AGBL1

5.95e-0531493GO:0004181
GeneOntologyMolecularFunctioncarboxypeptidase activity

CPA6 CPB2 AGBL1

2.36e-0449493GO:0004180
GeneOntologyMolecularFunctionmetalloexopeptidase activity

CPA6 CPB2 AGBL1

6.77e-0470493GO:0008235
GeneOntologyMolecularFunctionmetallopeptidase activity

CPA6 CPB2 MMP3 AGBL1

1.45e-03200494GO:0008237
GeneOntologyMolecularFunctionexopeptidase activity

CPA6 CPB2 AGBL1

2.49e-03110493GO:0008238
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

1.13e-244324822GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

5.69e-244654822GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

1.43e-234854822GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

7.77e-235244822GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

1.98e-225474822GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

7.61e-225824822GO:0050906
GeneOntologyBiologicalProcessdetection of stimulus

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

7.94e-207224822GO:0051606
GeneOntologyBiologicalProcesssensory perception

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

3.40e-1610724822GO:0007600
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 MRGPRE LRRK2 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

4.61e-1613954824GO:0007186
DomainOlfact_rcpt

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

1.19e-243934822IPR000725
DomainG_PROTEIN_RECEP_F1_1

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 MRGPRE OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

8.70e-216854823PS00237
DomainG_PROTEIN_RECEP_F1_2

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 MRGPRE OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

1.06e-206914823PS50262
DomainGPCR_Rhodpsn

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 MRGPRE OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

1.09e-206924823IPR000276
DomainGPCR_Rhodpsn_7TM

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 MRGPRE OR52N5 OR2V1 OR2J3 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

1.30e-196704822IPR017452
Domain7tm_1

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 MRGPRE OR52N5 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

1.63e-196774822PF00001
DomainCARBOXYPEPT_ZN_2

CPA6 CPB2 AGBL1

1.50e-0519483PS00133
DomainCARBOXYPEPT_ZN_1

CPA6 CPB2 AGBL1

1.76e-0520483PS00132
DomainPeptidase_M14

CPA6 CPB2 AGBL1

2.72e-0523483PF00246
DomainPeptidase_M14

CPA6 CPB2 AGBL1

2.72e-0523483IPR000834
Domain-

CPA6 CPB2

1.79e-0484823.30.70.340
DomainPropep_M14

CPA6 CPB2

1.79e-048482PF02244
DomainM14A_act_pep

CPA6 CPB2

1.79e-048482IPR003146
DomainPropept_inh

CPA6 CPB2

8.58e-0417482IPR009020
DomainZn_pept

CPA6 CPB2

9.64e-0418482SM00631
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8B8 OR8G1

7.39e-224174121M4072
PathwayREACTOME_SENSORY_PERCEPTION

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8U8 OR8B8 OR8G1

4.60e-186364121M41834
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2J3 OR2J2 OR8U3 OR2V2 OR8D4 OR51B4 OR51B2 OR8U8 OR8G2P OR8B8 OR8G1

1.83e-163894117M14091
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR2W3 OR8D1 OR2J3 OR2J1 OR2J2 OR8B2 OR8B3

1.08e-0970417MM14984
PathwayREACTOME_SENSORY_PERCEPTION

OR2W3 OR8D1 OR2J3 OR2J1 OR2J2 OR8B2 OR8B3

1.10e-06190417MM15687
PathwayWP_GPCRS_ODORANT

MRGPRE OR8B2 OR8B3 OR8B8

1.09e-03157414MM15872
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8G2P OR8B8 OR8G1

1.02e-29340492111875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8G2P OR8B8 OR8G1

1.02e-29340492111802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8G2P OR8B8 OR8G1

1.23e-29343492132295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR5W2 OR2W3 OR5T3 OR8D1 OR8U1 OR9I1 OR52N5 OR2V1 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR51B4 OR51B2 OR8B3 OR8G2P OR8B8 OR8G1

1.48e-29346492114611657
Pubmed

The human olfactory receptor gene family.

OR5W2 OR2W3 OR5T3 OR8D1 OR9I1 OR52N5 OR2J3 OR2J1 OR2J2 OR8U3 OR2V2 OR8B2 OR8D4 OR8B3 OR8G2P OR8B8 OR8G1

5.85e-19541491714983052
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR5W2 OR2W3 OR9I1 OR2J3 OR2V2 OR8B2 OR51B2 OR8B8 OR8G1

2.18e-1121949912213199
Pubmed

Characterization of a cluster comprising approximately 100 odorant receptor genes in mouse.

OR8D1 OR8G2P OR8B8 OR8G1

7.25e-101049411130974
Pubmed

Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.

OR8D1 OR8G2P OR8B8 OR8G1

3.62e-08244949119360
Pubmed

A probabilistic classifier for olfactory receptor pseudogenes.

OR2J3 OR2J2 OR8U3 OR51B2

1.76e-073549416939646
Pubmed

Identification of ligands for olfactory receptors by functional expression of a receptor library.

OR8U1 OR2V1 OR8G1

5.73e-07124939875846
Pubmed

Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex.

OR2J3 OR2J1 OR2J2

7.44e-071349314506126
Pubmed

The chromosomal distribution of mouse odorant receptor genes.

GPI OR8B2 OR8B3 OR8B8

1.04e-06544948570653
Pubmed

Induction of hepatoma cells migration by phosphoglucose isomerase/autocrine motility factor through the upregulation of matrix metalloproteinase-3.

GPI MMP3

1.94e-06249214715248
Pubmed

Autocrine motility factor stimulates the invasiveness of malignant cells as well as up-regulation of matrix metalloproteinase-3 expression via a MAPK pathway.

GPI MMP3

1.94e-06249218485900
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR5W2 OR2W3 OR9I1 OR8G1

3.72e-067449415081110
Pubmed

The complete human olfactory subgenome.

OR2J3 OR2J2

5.83e-06349211337468
Pubmed

Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.

OR5W2 OR8G2P OR8G1

7.51e-062749332061665
Pubmed

Mouse orthologs of human olfactory-like receptors expressed in the tongue.

OR8D1 OR8B8

2.91e-05649216859840
Pubmed

Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.

OR2V1 OR2J3 OR2V2

3.82e-054649332126975
Pubmed

Gene polymorphisms related to angiogenesis, inflammation and thrombosis that influence risk for oral cancer.

CPB2 MMP3

6.96e-05949218674955
Pubmed

Common variation contributes to the genetic architecture of social communication traits.

OR2J3 OR2J2

8.69e-051049224047820
Pubmed

Complex transcription and splicing of odorant receptor genes.

OR2J3 OR2J2

1.06e-041149212637542
Pubmed

Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters.

OR51B4 OR51B2

2.02e-041549211121057
Pubmed

Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.

OR51B4 OR51B2

2.02e-041549210220430
Pubmed

New GPCRs from a human lingual cDNA library.

OR8D1 OR8B8

2.61e-041749211705801
Pubmed

Personal receptor repertoires: olfaction as a model.

OR8U3 OR51B2

1.32e-033849222908908
CytobandEnsembl 112 genes in cytogenetic band chr11q24

OR8D1 OR8B2 OR8D4 OR8B3 OR8G2P OR8B8 OR8G1

1.43e-09191497chr11q24
Cytoband11q24.2

OR8D1 OR8B3 OR8G2P OR8B8 OR8G1

7.53e-096349511q24.2
CytobandEnsembl 112 genes in cytogenetic band chr11q12

OR5W2 OR5T3 OR8U1 OR9I1 OR8U3 BSCL2

1.84e-06345496chr11q12
Cytoband11q12.1

OR5T3 OR8U1 OR9I1 OR8U3

2.73e-0516149411q12.1
Cytoband11q24.1

OR8B2 OR8D4

7.26e-043749211q24.1
Cytoband11p15

OR51B4 OR51B2

9.80e-044349211p15
Cytoband11q11

OR5W2 OR8U8

1.17e-034749211q11
Cytoband12q12

LRRK2 PUS7L

1.17e-034749212q12
CytobandEnsembl 112 genes in cytogenetic band chr12q12

LRRK2 PUS7L

2.09e-0363492chr12q12
CytobandEnsembl 112 genes in cytogenetic band chr11p15

MRGPRE OR52N5 OR51B4 OR51B2

3.08e-03564494chr11p15
Cytoband5q35.3

OR2V1 OR2V2

4.68e-03954925q35.3
CytobandEnsembl 112 genes in cytogenetic band chr6p22

OR2J3 OR2J1 OR2J2

7.71e-03378493chr6p22
Cytoband6p22.1

OR2J3 OR2J1

1.02e-021424926p22.1
GeneFamilyOlfactory receptors, family 8

OR8D1 OR8U1 OR8B2 OR8D4 OR8B3 OR8U8 OR8G2P OR8B8 OR8G1

5.57e-1649389155
GeneFamilyOlfactory receptors, family 2

OR2W3 OR2V1 OR2J3 OR2J1 OR2J2 OR2V2

1.22e-07113386149
GeneFamilyCarboxypeptidases

CPA6 CPB2

8.81e-04213821321
GeneFamilyOlfactory receptors, family 5

OR5W2 OR5T3 OR8U3

1.67e-03112383152
GeneFamilyOlfactory receptors, family 51

OR51B4 OR51B2

3.85e-0344382164
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-5|TCGA-Endometrium / Sample_Type by Project: Shred V9

OR8D1 OR8B2 OR8G2P OR8B8

2.08e-0686474df7afc5707bb7296cfed6c4027414505d262af09
Diseasecathepsin L1 measurement

PLXDC2 LRRK2

2.46e-0416432EFO_0010619
Diseasepartial thromboplastin time

PLXDC2 AGBL1

5.61e-0424432EFO_0004310
Diseaseamyotrophic lateral sclerosis (is_marker_for)

HDAC4 LRRK2

8.21e-0429432DOID:332 (is_marker_for)
Diseaseacute lymphoblastic leukemia (is_marker_for)

GPI HDAC4

1.13e-0334432DOID:9952 (is_marker_for)
Diseaseemphysema imaging measurement

MMP3 OR8B2 OR8B3

1.27e-03146433EFO_0007626
Diseasecomplement factor H measurement

GPI CPA6

1.64e-0341432EFO_0008097
Diseasediabetes mellitus (is_marker_for)

CPB2 MMP3

1.64e-0341432DOID:9351 (is_marker_for)
Disease3-hydroxy-1-methylpropylmercapturic acid measurement

PLXDC2 RNF103 EXT1 AGBL1

1.70e-03352434EFO_0007015
DiseasePeripheral Nervous System Diseases

CPT1C MMP3

2.83e-0354432C4721453

Protein segments in the cluster

PeptideGeneStartEntry
STLDYLHYNRYHLPM

CFAP61

1216

Q8NHU2
LSFHAYAQMLLYPYS

CPA6

321

Q8N4T0
HYPYTYTALMTHLDI

AGBL1

731

Q96MI9
LNSHLHTPMYFFLYN

OR8B8

51

Q15620
MPALFSDHTFRHYAY

INTS4

561

Q96HW7
LIGLSSHLHTPMYYF

OR8G2P

61

Q6IF36
SHLHTPMYYFLSGLS

OR8G2P

66

Q6IF36
HTPMYYFLSSLSFVD

OR8D1

56

Q8WZ84
MDYQLHTPMYFFLSH

OR5W2

51

Q8NH69
HTPMYFFLSHLSFCD

OR5W2

56

Q8NH69
YTPMYFFLSHLSLLD

OR9I1

56

Q8NGQ6
AVPYSYSFLMALFHT

OR8U8

146

P0C7N1
HTPMYYFLSSLSFLD

OR8D4

56

Q8NGM9
LSSHLHTPMYYFLSS

OR8G1

51

Q15617
HTPMYYFLSSLSFID

OR8G1

56

Q15617
YLDSHLHTPMYFFLS

OR2J1

51

Q9GZK6
FYSDPSVLYMSLHRY

HDAC4

851

P56524
AAFPYRHYCTMFHTL

FNDC9

81

Q8TBE3
YLHFTMSPYHQPTSY

ATAD2B

751

Q9ULI0
LFHSANTEALMYPLY

MMP3

226

P08254
HSLHEPMYYFLTMLA

OR51B2

51

Q9Y5P1
HSLHEPMYYFLAMLA

OR51B4

51

Q9Y5P0
YLDAGLHTPMYFFLS

OR2V1

51

Q8NHB1
YMDPHLHTPMYFFLS

OR2V2

51

Q96R30
HTPMYFFLAHLSFLD

OR2W3

56

Q7Z3T1
YSLFYHAHVASQPVM

GANC

681

Q8TET4
FYSTHPHFMTQRALY

LRRK2

1401

Q5S007
HAMLPYDQYLHRFAA

GPI

336

P06744
IYHLPSFHYLMDSEA

METTL21EP

26

A6NDL7
YVDSHLHTPMYFFLS

OR2J2

51

O76002
LNSHLHTPMYYFLFN

OR8B3

51

Q8NGG8
IPHYFYHFSFLMAAV

MRGPRE

246

Q86SM8
MHLFDVHNYPDYVSS

CPT1C

691

Q8TCG5
HYLYSHYLPASLKNM

EXT1

631

Q16394
YISMHSYSQHIVFPY

CPB2

306

Q96IY4
SMIYFFHHYELPAIL

TMEM259

441

Q4ZIN3
YMPTVSHLSPVHFYY

BSCL2

56

Q96G97
MFYSSHPALFLSTYL

RNF103

411

O00237
HNPMYYFLSVLSFLD

OR5T3

86

Q8NGG3
LIYYEESLHHPMYFF

OR52N5

56

Q8NH56
LNSHLHTPMYYFLFN

OR8B2

51

Q96RD0
LSYLDSHLHTPMYFF

OR2J3

51

O76001
AVPYSYSFLMALFHT

OR8U1

146

Q8NH10
LSSHLHTPMYYFLSS

OR8G3P

51

P0DMU2
HTPMYYFLSSLSFID

OR8G3P

56

P0DMU2
LYFHHYFPAMLFSSM

POMT2

661

Q9UKY4
IALMLFNFIYSAPHY

FER1L5

1971

A0AVI2
SLPHSMRIFYVHAYT

PUS7L

521

Q9H0K6
YMYHHPTSAASIFFI

PLXDC2

476

Q6UX71
LMHYDYSSHKYVFSI

ST8SIA3

126

O43173
IDTRLHTPMYYFLSH

OR8U3

51

Q8NH85
HTPMYYFLSHLAFVD

OR8U3

56

Q8NH85
FLSRPMYAHHISSKY

THOC2

816

Q8NI27
TLSYYFVFDHALMKH

SC5D

51

O75845
YKHSLHHYTYLPDAM

NEB

1161

P20929