Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phorbol ester receptor activity	UNC13B UNC13C	7.73e-06	2	56	2	GO:0001565
GeneOntologyMolecularFunction	non-kinase phorbol ester receptor activity	UNC13B UNC13C	7.73e-06	2	56	2	GO:0001566
GeneOntologyMolecularFunction	diacylglycerol binding	UNC13B UNC13C FITM1	1.14e-05	16	56	3	GO:0019992
GeneOntologyMolecularFunction	corticotropin-releasing hormone receptor activity	CRHR1 CRHR2	2.31e-05	3	56	2	GO:0043404
GeneOntologyMolecularFunction	corticotrophin-releasing factor receptor activity	CRHR1 CRHR2	2.31e-05	3	56	2	GO:0015056
GeneOntologyMolecularFunction	lipid binding	UNC13B MARK1 RASA4 OPN3 OBSCN HIP1R RASA4B UNC13C FITM1 ACOX2	3.75e-04	988	56	10	GO:0008289
GeneOntologyMolecularFunction	calmodulin binding	UNC13B USP6 MYO5B OBSCN UNC13C	4.60e-04	230	56	5	GO:0005516
GeneOntologyMolecularFunction	G protein-coupled receptor activity	HTR1E OR2L3 OPN3 ADGRV1 OR2H1 OR7A2P CRHR1 CRHR2 OR2H2	7.31e-04	884	56	9	GO:0004930
GeneOntologyMolecularFunction	oxidoreductase activity, acting on CH or CH2 groups	VKORC1L1 ACOX2	7.92e-04	15	56	2	GO:0016725
GeneOntologyMolecularFunction	phospholipid binding	UNC13B MARK1 RASA4 OBSCN HIP1R RASA4B UNC13C	8.17e-04	548	56	7	GO:0005543
GeneOntologyMolecularFunction	syntaxin-1 binding	UNC13B UNC13C	2.05e-03	24	56	2	GO:0017075
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate binding	MARK1 OBSCN HIP1R	2.41e-03	95	56	3	GO:0005546
GeneOntologyBiologicalProcess	dense core granule priming	UNC13B UNC13C	4.17e-05	4	55	2	GO:0061789
GeneOntologyBiologicalProcess	cellular response to corticotropin-releasing hormone stimulus	CRHR1 CRHR2	1.04e-04	6	55	2	GO:0071376
GeneOntologyBiologicalProcess	negative regulation of synaptic plasticity	UNC13B UNC13C	1.04e-04	6	55	2	GO:0031914
GeneOntologyBiologicalProcess	response to corticotropin-releasing hormone	CRHR1 CRHR2	1.04e-04	6	55	2	GO:0043435
Domain	Unc-13	UNC13B UNC13C	2.28e-05	3	52	2	IPR027080
Domain	-	RASA4 RASA4B	2.28e-05	3	52	2	4.10.1130.10
Domain	GPCR_2_CRF_rcpt	CRHR1 CRHR2	2.28e-05	3	52	2	IPR003051
Domain	Munc13_dom-2	UNC13B UNC13C	7.56e-05	5	52	2	IPR014772
Domain	Membr_traf_MHD	UNC13B UNC13C	7.56e-05	5	52	2	PF10540
Domain	MHD2	UNC13B UNC13C	7.56e-05	5	52	2	PS51259
Domain	Munc13_subgr_dom-2	UNC13B UNC13C	7.56e-05	5	52	2	IPR019558
Domain	DUF1041	UNC13B UNC13C	7.56e-05	5	52	2	SM01145
Domain	C2_dom	UNC13B PREB RASA4 RASA4B UNC13C	9.14e-05	164	52	5	IPR000008
Domain	DUF1041	UNC13B UNC13C	1.58e-04	7	52	2	PF06292
Domain	Munc13_1	UNC13B UNC13C	1.58e-04	7	52	2	IPR014770
Domain	CAPS_dom	UNC13B UNC13C	1.58e-04	7	52	2	IPR010439
Domain	MHD1	UNC13B UNC13C	1.58e-04	7	52	2	PS51258
Domain	G_PROTEIN_RECEP_F2_1	ADGRV1 CRHR1 CRHR2	1.87e-04	40	52	3	PS00649
Domain	GPCR_2_extracellular_dom	ADGRV1 CRHR1 CRHR2	1.87e-04	40	52	3	IPR001879
Domain	G_PROTEIN_RECEP_F2_3	ADGRV1 CRHR1 CRHR2	1.87e-04	40	52	3	PS50227
Domain	BTK	RASA4 RASA4B	2.70e-04	9	52	2	SM00107
Domain	Znf_Btk_motif	RASA4 RASA4B	2.70e-04	9	52	2	IPR001562
Domain	BTK	RASA4 RASA4B	2.70e-04	9	52	2	PF00779
Domain	ZF_BTK	RASA4 RASA4B	2.70e-04	9	52	2	PS51113
Domain	G_PROTEIN_RECEP_F2_2	ADGRV1 CRHR1 CRHR2	3.64e-04	50	52	3	PS00650
Domain	7tm_2	ADGRV1 CRHR1 CRHR2	3.64e-04	50	52	3	PF00002
Domain	C2	UNC13B RASA4 RASA4B UNC13C	4.82e-04	131	52	4	PF00168
Domain	C2	UNC13B RASA4 RASA4B UNC13C	5.71e-04	137	52	4	SM00239
Domain	GPCR_2_secretin-like	ADGRV1 CRHR1 CRHR2	6.23e-04	60	52	3	IPR000832
Domain	GPCR_2-like	ADGRV1 CRHR1 CRHR2	6.23e-04	60	52	3	IPR017981
Domain	C2	UNC13B RASA4 RASA4B UNC13C	6.53e-04	142	52	4	PS50004
Domain	G_PROTEIN_RECEP_F2_4	ADGRV1 CRHR1 CRHR2	6.54e-04	61	52	3	PS50261
Domain	RasGAP	RASA4 RASA4B	6.77e-04	14	52	2	SM00323
Domain	RasGAP_CS	RASA4 RASA4B	6.77e-04	14	52	2	IPR023152
Domain	-	UNC13B RASA4 RASA4B UNC13C	7.63e-04	148	52	4	2.60.40.150
Domain	RasGAP	RASA4 RASA4B	7.80e-04	15	52	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA4 RASA4B	7.80e-04	15	52	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	RASA4 RASA4B	7.80e-04	15	52	2	PS50018
Domain	USP_CS	USP6 USP51 USP21	8.23e-04	66	52	3	IPR018200
Domain	-	RASA4 RASA4B	8.90e-04	16	52	2	1.10.506.10
Domain	USP_1	USP6 USP51 USP21	9.77e-04	70	52	3	PS00972
Domain	UCH	USP6 USP51 USP21	1.02e-03	71	52	3	PF00443
Domain	USP_2	USP6 USP51 USP21	1.02e-03	71	52	3	PS00973
Domain	USP_3	USP6 USP51 USP21	1.06e-03	72	52	3	PS50235
Domain	USP_dom	USP6 USP51 USP21	1.06e-03	72	52	3	IPR028889
Domain	Peptidase_C19_UCH	USP6 USP51 USP21	1.06e-03	72	52	3	IPR001394
Domain	RasGAP_dom	RASA4 RASA4B	1.13e-03	18	52	2	IPR001936
Domain	CTCK_1	CCN6 SLIT1	1.13e-03	18	52	2	PS01185
Domain	IQ	IQCH MYO5B OBSCN	1.49e-03	81	52	3	SM00015
Domain	CT	CCN6 SLIT1	1.69e-03	22	52	2	SM00041
Domain	IQ_motif_EF-hand-BS	IQCH MYO5B OBSCN	2.02e-03	90	52	3	IPR000048
Domain	Cys_knot_C	CCN6 SLIT1	2.19e-03	25	52	2	IPR006207
Domain	CTCK_2	CCN6 SLIT1	2.19e-03	25	52	2	PS01225
Domain	HormR	CRHR1 CRHR2	2.19e-03	25	52	2	SM00008
Domain	IQ	IQCH MYO5B OBSCN	2.21e-03	93	52	3	PS50096
Domain	-	EYS SLIT1 ADGRV1	2.35e-03	95	52	3	2.60.120.200
Domain	hEGF	EYS SLIT1	2.74e-03	28	52	2	PF12661
Domain	HRM	CRHR1 CRHR2	2.74e-03	28	52	2	PF02793
Domain	GPCR_2_secretin-like_CS	CRHR1 CRHR2	4.03e-03	34	52	2	IPR017983
Domain	LAM_G_DOMAIN	EYS SLIT1	5.01e-03	38	52	2	PS50025
Domain	Laminin_G_2	EYS SLIT1	5.54e-03	40	52	2	PF02210
Domain	PH_dom-like	JAK1 PTPN13 RASA4 OBSCN RASA4B	6.50e-03	426	52	5	IPR011993
Domain	LamG	EYS SLIT1	6.67e-03	44	52	2	SM00282
Domain	FERM_central	JAK1 PTPN13	8.22e-03	49	52	2	IPR019748
Domain	FERM_domain	JAK1 PTPN13	8.22e-03	49	52	2	IPR000299
Domain	FERM_1	JAK1 PTPN13	8.55e-03	50	52	2	PS00660
Domain	FERM_2	JAK1 PTPN13	8.55e-03	50	52	2	PS00661
Domain	FERM_3	JAK1 PTPN13	8.55e-03	50	52	2	PS50057
Pubmed	Expression of corticotropin-releasing hormone receptor type 1 and type 2 in human pregnant myometrium.	CRHR1 CRHR2	2.55e-06	2	56	2	17959885
Pubmed	Differential regulation of prostaglandin production mediated by corticotropin-releasing hormone receptor type 1 and type 2 in cultured human placental trophoblasts.	CRHR1 CRHR2	2.55e-06	2	56	2	18325997
Pubmed	Association study between the corticotropin-releasing hormone receptor 2 gene and suicidality in bipolar disorder.	CRHR1 CRHR2	2.55e-06	2	56	2	17532191
Pubmed	The highly selective CRF(2) receptor antagonist K41498 binds to presynaptic CRF(2) receptors in rat brain.	CRHR1 CRHR2	2.55e-06	2	56	2	12110614
Pubmed	HPA axis genes may modulate the effect of childhood adversities on decision-making in suicide attempters.	CRHR1 CRHR2	2.55e-06	2	56	2	23177644
Pubmed	Expression and subcellular localization of CRH and its receptors in human endometrial cancer.	CRHR1 CRHR2	2.55e-06	2	56	2	19433256
Pubmed	Different effects of chronic social defeat on social behavior and the brain CRF system in adult male C57 mice with different susceptibilities.	CRHR1 CRHR2	2.55e-06	2	56	2	32057826
Pubmed	Molecular mechanisms of corticotropin-releasing factor receptor-induced calcium signaling.	CRHR1 CRHR2	2.55e-06	2	56	2	19098121
Pubmed	Distinct distribution of corticotropin releasing factor receptors in human breast cancer.	CRHR1 CRHR2	2.55e-06	2	56	2	20630588
Pubmed	Corticotropin-releasing factor receptors induce calcium mobilization through cross-talk with Gq-coupled receptors.	CRHR1 CRHR2	2.55e-06	2	56	2	20594969
Pubmed	Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome.	CRHR1 CRHR2	2.55e-06	2	56	2	37543650
Pubmed	Effect of CRHR1 and CRHR2 gene polymorphisms and childhood trauma in suicide attempt.	CRHR1 CRHR2	2.55e-06	2	56	2	30874897
Pubmed	Expression and functional characterization of membrane-integrated mammalian corticotropin releasing factor receptors 1 and 2 in Escherichia coli.	CRHR1 CRHR2	2.55e-06	2	56	2	24465390
Pubmed	Munc13-independent vesicle priming at mouse photoreceptor ribbon synapses.	UNC13B UNC13C	2.55e-06	2	56	2	22674279
Pubmed	Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population.	CRHR1 CRHR2	2.55e-06	2	56	2	22467522
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	2.55e-06	2	56	2	11448776
Pubmed	Dysregulation of bladder corticotropin-releasing hormone receptor in the pathogenesis of human interstitial cystitis/bladder pain syndrome.	CRHR1 CRHR2	2.55e-06	2	56	2	31844086
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	2.55e-06	2	56	2	16041389
Pubmed	Association between corticotropin-releasing hormone receptor 1 and 2 (CRHR1 and CRHR2) gene polymorphisms and personality traits.	CRHR1 CRHR2	2.55e-06	2	56	2	23982282
Pubmed	Corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 are both trafficking and signaling receptors for urocortin.	CRHR1 CRHR2	2.55e-06	2	56	2	17170072
Pubmed	Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout mice.	CRHR1 CRHR2	2.55e-06	2	56	2	21487655
Pubmed	Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians.	CRHR1 CRHR2	2.55e-06	2	56	2	14724656
Pubmed	Corticotropin-Releasing Hormone Family and Their Receptors in the Cardiovascular System.	CRHR1 CRHR2	2.55e-06	2	56	2	30584229
Pubmed	Corticotropin-releasing hormone receptor expression on normal and tumorous human adrenocortical cells.	CRHR1 CRHR2	2.55e-06	2	56	2	16721033
Pubmed	Estrogen alters the splicing of type 1 corticotropin-releasing hormone receptor in breast cancer cells.	CRHR1 CRHR2	2.55e-06	2	56	2	23821771
Pubmed	Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis.	CRHR1 CRHR2	7.63e-06	3	56	2	20206175
Pubmed	Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior.	CRHR1 CRHR2	7.63e-06	3	56	2	11756502
Pubmed	Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptides.	CRHR1 CRHR2	7.63e-06	3	56	2	14670995
Pubmed	Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts.	CRHR1 CRHR2	7.63e-06	3	56	2	17463062
Pubmed	Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair.	CRHR1 CRHR2	7.63e-06	3	56	2	28492284
Pubmed	Jak1-STAT3 Signals Are Essential Effectors of the USP6/TRE17 Oncogene in Tumorigenesis.	JAK1 USP6	7.63e-06	3	56	2	27440725
Pubmed	Corticotropin releasing hormone receptor alterations elicited by acute and chronic unpredictable stressor challenges in stressor-susceptible and resilient strains of mice.	CRHR1 CRHR2	7.63e-06	3	56	2	17517441
Pubmed	Corticotropin-releasing hormone receptor-1 in cerebral microvessels changes during development and influences urocortin transport across the blood-brain barrier.	CRHR1 CRHR2	7.63e-06	3	56	2	20032050
Pubmed	The CRF1 and the CRF2 receptor mediate recognition memory deficits and vulnerability induced by opiate withdrawal.	CRHR1 CRHR2	7.63e-06	3	56	2	26907806
Pubmed	The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.	UNC13B UNC13C	7.63e-06	3	56	2	23658173
Pubmed	Distribution of corticotropin-releasing factor (CRF) receptor binding in the mouse brain using a new, high-affinity radioligand, [125 I]-PD-Sauvagine.	CRHR1 CRHR2	7.63e-06	3	56	2	28842924
Pubmed	CRF1 and CRF2 receptors are required for potentiated startle to contextual but not discrete cues.	CRHR1 CRHR2	7.63e-06	3	56	2	19020499
Pubmed	Corticotropin-releasing factor receptors CRF1 and CRF2 exert both additive and opposing influences on defensive startle behavior.	CRHR1 CRHR2	7.63e-06	3	56	2	15269266
Pubmed	Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart.	CRHR1 CRHR2	7.63e-06	3	56	2	7565810
Pubmed	Reduced cerebral injury in CRH-R1 deficient mice after focal ischemia: a potential link to microglia and atrocytes that express CRH-R1.	CRHR1 CRHR2	7.63e-06	3	56	2	14526225
Pubmed	Stress-induced differences in primary and secondary resistance against bacterial sepsis corresponds with diverse corticotropin releasing hormone receptor expression by pulmonary CD11c+ MHC II+ and CD11c- MHC II+ APCs.	CRHR1 CRHR2	7.63e-06	3	56	2	18166336
Pubmed	Corticotropin-releasing factor, urocortin 1, and their receptors in the mouse spinal cord.	CRHR1 CRHR2	7.63e-06	3	56	2	17444496
Pubmed	Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.	UNC13B UNC13C	7.63e-06	3	56	2	33105896
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	7.63e-06	3	56	2	25637021
Pubmed	Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2.	CRHR1 CRHR2	7.63e-06	3	56	2	11606463
Pubmed	Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress.	CRHR1 CRHR2	7.63e-06	3	56	2	11337086
Pubmed	Plasma Corticotropin-Releasing Factor Receptors and B7-2⁺ Extracellular Vesicles in Blood Correlate with Irritable Bowel Syndrome Disease Severity.	CRHR1 CRHR2	7.63e-06	3	56	2	30704133
Pubmed	Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus.	CRHR1 CRHR2	7.63e-06	3	56	2	22030710
Pubmed	Increased depression-like behaviors in corticotropin-releasing factor receptor-2-deficient mice: sexually dichotomous responses.	CRHR1 CRHR2	7.63e-06	3	56	2	12832554
Pubmed	DNA methylation of HPA-axis genes and the onset of major depressive disorder in adolescent girls: a prospective analysis.	CRHR1 CRHR2	7.63e-06	3	56	2	31582756
Pubmed	The role of hypothalamus-pituitary-adrenal genes and childhood trauma in borderline personality disorder.	CRHR1 CRHR2	7.63e-06	3	56	2	26182893
Pubmed	Corticotropin-releasing hormone receptor-1 and 2 activity produces divergent resistance against stress-induced pulmonary Streptococcus pneumoniae infection.	CRHR1 CRHR2	7.63e-06	3	56	2	21774994
Pubmed	Lack of interaction between etifoxine and CRF1 and CRF2 receptors in rodents.	CRHR1 CRHR2	7.63e-06	3	56	2	16769145
Pubmed	Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.	UNC13B UNC13C	7.63e-06	3	56	2	22966208
Pubmed	Transcription-coupled DNA-protein crosslink repair by CSB and CRL4CSA-mediated degradation.	ERCC6 IL17RB	7.63e-06	3	56	2	38600236
Pubmed	Activated CRH receptors inhibit autophagy by repressing conversion of LC3BI to LC3BII.	CRHR1 CRHR2	7.63e-06	3	56	2	30849520
Pubmed	Sex-Dependent Effects of Mild Blast-induced Traumatic Brain Injury on Corticotropin-releasing Factor Receptor Gene Expression: Potential Link to Anxiety-like Behaviors.	CRHR1 CRHR2	7.63e-06	3	56	2	30248435
Pubmed	A single episode of restraint stress regulates central corticotrophin- releasing hormone receptor expression and binding in specific areas of the mouse brain.	CRHR1 CRHR2	7.63e-06	3	56	2	19302188
Pubmed	Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors.	CRHR1 CRHR2	7.63e-06	3	56	2	21722209
Pubmed	Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.	UNC13B UNC13C	7.63e-06	3	56	2	15988013
Pubmed	The effects of repeated restraint stress on energy balance and behavior of mice with selective deletion of CRF receptors.	CRHR1 CRHR2	7.63e-06	3	56	2	20392192
Pubmed	Suppression of the MEK/ERK signaling pathway reverses depression-like behaviors of CRF2-deficient mice.	CRHR1 CRHR2	7.63e-06	3	56	2	18843268
Pubmed	Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor.	CRHR1 CRHR2	1.52e-05	4	56	2	20966082
Pubmed	Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation.	CRHR1 CRHR2	1.52e-05	4	56	2	22451915
Pubmed	Enhanced pelvic responses to stressors in female CRF-overexpressing mice.	CRHR1 CRHR2	1.52e-05	4	56	2	17194724
Pubmed	Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism.	CRHR1 CRHR2	1.52e-05	4	56	2	18591672
Pubmed	Distribution and expression of CRF receptor 1 and 2 mRNAs in the CRF over-expressing mouse brain.	CRHR1 CRHR2	1.52e-05	4	56	2	16423327
Pubmed	Corticotropin-releasing hormone, its binding protein and receptors in human cervical tissue at preterm and term labor in comparison to non-pregnant state.	CRHR1 CRHR2	1.52e-05	4	56	2	16734917
Pubmed	Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term.	CRHR1 CRHR2	1.52e-05	4	56	2	12784189
Pubmed	Predicting risk of bacterial vaginosis: the role of race, smoking and corticotropin-releasing hormone-related genes.	CRHR1 CRHR2	1.52e-05	4	56	2	19131402
Pubmed	Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.	RASA4 RASA4B	1.52e-05	4	56	2	21460216
Pubmed	Corticotropin-releasing hormone receptors mediate apoptosis via cytosolic calcium-dependent phospholipase A₂ and migration in prostate cancer cell RM-1.	CRHR1 CRHR2	1.52e-05	4	56	2	24776847
Pubmed	Cloning and characterization of human urocortin.	CRHR1 CRHR2	1.52e-05	4	56	2	8612563
Pubmed	Corticotropin-releasing hormone system in human adipose tissue.	CRHR1 CRHR2	1.52e-05	4	56	2	14764822
Pubmed	Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.	RASA4 RASA4B	1.52e-05	4	56	2	16234249
Pubmed	Urocortin II gene is highly expressed in mouse skin and skeletal muscle tissues: localization, basal expression in corticotropin-releasing factor receptor (CRFR) 1- and CRFR2-null mice, and regulation by glucocorticoids.	CRHR1 CRHR2	1.52e-05	4	56	2	14736736
Pubmed	Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin.	CRHR1 CRHR2	1.52e-05	4	56	2	9423932
Pubmed	Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors.	CRHR1 CRHR2	1.52e-05	4	56	2	15001778
Pubmed	Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis.	CRHR1 CRHR2	1.52e-05	4	56	2	30214395
Pubmed	Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling.	CRHR1 CRHR2	2.54e-05	5	56	2	19077175
Pubmed	An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.	UNC13B UNC13C	2.54e-05	5	56	2	34706221
Pubmed	Dissection of corticotropin-releasing factor system involvement in locomotor sensitivity to methamphetamine.	CRHR1 CRHR2	2.54e-05	5	56	2	20731720
Pubmed	Regulation of corticotropin-releasing factor and urocortin 2/3 mRNA by leptin in hypothalamic N39 cells.	CRHR1 CRHR2	2.54e-05	5	56	2	24083959
Pubmed	Differential regulation of glucose transporters mediated by CRH receptor type 1 and type 2 in human placental trophoblasts.	CRHR1 CRHR2	2.54e-05	5	56	2	22234467
Pubmed	CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior.	CRHR1 CRHR2	2.54e-05	5	56	2	20052275
Pubmed	Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.	UNC13B UNC13C	2.54e-05	5	56	2	26575293
Pubmed	Association of HPA axis genes with suicidal behaviour in schizophrenia.	CRHR1 CRHR2	3.80e-05	6	56	2	18838498
Pubmed	Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.	CRHR1 CRHR2	3.80e-05	6	56	2	11416224
Pubmed	Expression of corticotropin-releasing factor and urocortins in the normal and Schistosoma mansoni-infected mouse ileum.	CRHR1 CRHR2	3.80e-05	6	56	2	25358399
Pubmed	Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder.	CRHR1 CRHR2	3.80e-05	6	56	2	18384079
Pubmed	Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.	PREB RASA4 RASA4B USP21	5.21e-05	126	56	4	24319055
Pubmed	Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.	UNC13B UNC13C	5.32e-05	7	56	2	36398873
Pubmed	The DNA sequence and analysis of human chromosome 6.	CCN6 EYS HTR1E MBOAT1 OR2H1 TMEM181 OR2H2	6.14e-05	622	56	7	14574404
Pubmed	Expression of genes related to the hypothalamic-pituitary-adrenal axis in murine fetal lungs in late gestation.	CRHR1 CRHR2	7.09e-05	8	56	2	21050473
Pubmed	Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.	RASA4 RASA4B	7.09e-05	8	56	2	10810084
Pubmed	Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions.	MARK1 USP21	7.09e-05	8	56	2	22298430
Pubmed	Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.	UNC13B UNC13C	7.09e-05	8	56	2	25609709
Pubmed	Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response.	CRHR1 CRHR2	1.14e-04	10	56	2	20368512
Pubmed	Complex transcription and splicing of odorant receptor genes.	OR2H1 OR2H2	1.39e-04	11	56	2	12637542
Pubmed	Molecular and functional architecture of striatal dopamine release sites.	UNC13B UNC13C	1.39e-04	11	56	2	34767769
Interaction	UCN3 interactions	BTD ADGRV1 CRHR1 CRHR2	3.64e-07	23	53	4	int:UCN3
GeneFamily	Corticotropin releasing hormone receptors	CRHR1 CRHR2	4.08e-06	2	37	2	266
GeneFamily	UNC13 homologs	UNC13B UNC13C	2.44e-05	4	37	2	836
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	1.81e-04	10	37	2	830
GeneFamily	Ubiquitin specific peptidases	USP6 USP51 USP21	2.03e-04	56	37	3	366
GeneFamily	Olfactory receptors, family 2	OR2L3 OR2H1 OR2H2	1.58e-03	113	37	3	149
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	JAK1 PTPN13	4.69e-03	50	37	2	1293
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_PULMONARY_NE_PRECURSOR_CELL	TMEM184A MARK1 RASA4 SLIT1 RASA4B TMEM181 CASZ1	3.32e-06	304	55	7	M45711
ToppCell	PND01-03-samps-Mesenchymal-Pericyte\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	NAA25 MBOAT1 MARK1 OBSCN ACOX2	1.37e-06	152	56	5	fc9472bc19f997103da535b035105f01429cb08e
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTCHD1 PTPN13 VKORC1L1 UNC13C ADGRV1	3.49e-06	184	56	5	102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	UNC13B PTCHD1 PTPN13 UNC13C ADGRV1	3.59e-06	185	56	5	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	COPD-Epithelial-Club\|World / Disease state, Lineage and Cell class	UNC13B PTCHD1 PTPN13 MYO5B ADGRV1	3.68e-06	186	56	5	3006f4ab1eaf1eb34c10ca9f7c869603d2d25744
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	UNC13B PTPN13 MYO5B ADGRV1 CASZ1	3.88e-06	188	56	5	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B HIP1R ADGRV1 IL17RB	3.98e-06	189	56	5	5d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B HIP1R ADGRV1 IL17RB	4.30e-06	192	56	5	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	UNC13B PTPN13 MYO5B VKORC1L1 ADGRV1	5.12e-06	199	56	5	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	UNC13B PTPN13 MYO5B VKORC1L1 ADGRV1	5.12e-06	199	56	5	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B PTPN13 IQCH UNC13C	4.66e-05	158	56	4	f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B PTPN13 IQCH UNC13C	4.66e-05	158	56	4	8c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	UNC13B PTCHD1 PTPN13 ADGRV1	5.65e-05	166	56	4	c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	MBOAT1 OBSCN KMT2E INTS3	5.65e-05	166	56	4	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	UNC13B PTCHD1 PTPN13 ADGRV1	6.20e-05	170	56	4	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TNNI3K UNC13C CASZ1 CRHR2	6.20e-05	170	56	4	8ab67e2b6e30fdf9e9a2c02e31d4df34e751a3ed
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m-Myeloid-new-cluster\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM184A MYO5B DOCK8 CHST12	6.78e-05	174	56	4	718e14d9a4264456459bec4c062c94c3a848d43a
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM184A MYO5B DOCK8 CHST12	6.94e-05	175	56	4	61fdafba120fbda063d4dc05263d6f8d1dcab1e1
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM184A MYO5B DOCK8 CHST12	6.94e-05	175	56	4	8de8031fdf2af187642833feb80caa64932897cf
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122\|Adult / Lineage, Cell type, age group and donor	PTCHD1 PTPN13 UNC13C ADGRV1	7.09e-05	176	56	4	3fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCell	COVID-19-Epithelial_cells-AT1\|COVID-19 / group, cell type (main and fine annotations)	UNC13B MYO5B ADGRV1 CASZ1	7.57e-05	179	56	4	a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MBOAT1 DOCK8 UNC13C TMEM255A	7.74e-05	180	56	4	cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 MBOAT1 HIP1R CASZ1	7.74e-05	180	56	4	788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCell	Control-Epithelial_cells-Airway_club\|Control / group, cell type (main and fine annotations)	UNC13B PTCHD1 PTPN13 ADGRV1	7.90e-05	181	56	4	c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	UNC13B PTCHD1 PTPN13 ADGRV1	8.60e-05	185	56	4	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B HIP1R ADGRV1	8.78e-05	186	56	4	bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B HIP1R ADGRV1	8.96e-05	187	56	4	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	UNC13B PTCHD1 PTPN13 ADGRV1	8.96e-05	187	56	4	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PTPN13 MARK1 ADAM12 TMEM255A	9.15e-05	188	56	4	de6f4889e0c5f39fbbaefd85526f645c6afa09d5
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	UNC13B PTPN13 MYO5B ADGRV1	9.15e-05	188	56	4	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B HIP1R ADGRV1	9.53e-05	190	56	4	625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCell	facs-Heart-LV-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNNI3K MYO5B OBSCN FITM1	9.73e-05	191	56	4	9d7d680da3979e256191b534ebd14c5383e0cf93
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	UNC13B PTPN13 MYO5B ADGRV1	9.73e-05	191	56	4	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	facs-Heart-LV-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNNI3K MYO5B OBSCN FITM1	9.73e-05	191	56	4	543da1197c7e62f2c9cbd4a51414bbaaa6d1a92f
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	UNC13B PTPN13 MYO5B ADGRV1	9.73e-05	191	56	4	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B ADGRV1 IL17RB	9.92e-05	192	56	4	d3634574b2e8d2ded6446969361b70761b331aea
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B HIP1R ADGRV1	9.92e-05	192	56	4	b7c01e12b3e9be960a741b08835f1dfff65d0d47
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	UNC13B PTPN13 MYO5B ADGRV1	9.92e-05	192	56	4	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	UNC13B PTPN13 MYO5B ADGRV1	9.92e-05	192	56	4	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	droplet-Heart-nan-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNNI3K MYO5B OBSCN FITM1	9.92e-05	192	56	4	1a0c25106ae08eac912a4edd5fc1a3ee776f69c2
ToppCell	droplet-Heart-nan-24m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNNI3K MYO5B OBSCN FITM1	9.92e-05	192	56	4	f6a4e348406a852ace9fb21db8fbdff539217645
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B ADGRV1 IL17RB	9.92e-05	192	56	4	1aa5e4d9b32013a3f272561dcb8377f6805706df
ToppCell	Fetal_29-31_weeks-Epithelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	UNC13B PTPN13 MYO5B ADGRV1	1.01e-04	193	56	4	a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASA4 UNC13C ADAM12 CRHR1	1.01e-04	193	56	4	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B HIP1R ADGRV1	1.01e-04	193	56	4	4b8202fcfe639a73f69a13f48fc3601ade256346
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	UNC13B PTPN13 ADGRV1 CASZ1	1.03e-04	194	56	4	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	UNC13B PTPN13 MYO5B ADGRV1	1.03e-04	194	56	4	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B HIP1R ADGRV1	1.03e-04	194	56	4	c47fc3f716ab091a39c20d7639ac783029589ee5
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	UNC13B PTPN13 MYO5B ADGRV1	1.05e-04	195	56	4	9406866f99555198a9be311fbd65751b70f35446
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B HIP1R ADGRV1	1.05e-04	195	56	4	f08e41706680881ebd0afcd08a02f8ac0089f04e
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTPN13 PIP4K2A HIP1R ADAM12	1.07e-04	196	56	4	ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B HIP1R ADGRV1	1.07e-04	196	56	4	0a34a0009f479384f1994c6f977f942699a132c8
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B HIP1R ADGRV1	1.10e-04	197	56	4	22b26bac3a99b20c73bfa6e6f81026d064eaa9e8
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B HIP1R ADGRV1	1.10e-04	197	56	4	6852a8ec1397811bbdd1fc625c52ed4fa75a931e
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B HIP1R ADGRV1	1.10e-04	197	56	4	2f91b3870a7058168093a143110954c07588cfe9
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	UNC13B PTPN13 MYO5B ADGRV1	1.12e-04	198	56	4	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	UNC13B PTPN13 HTR1E ADGRV1	1.12e-04	198	56	4	6ba5e5970109a04ed968bac7ff099ae250c579dc
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	UNC13B PTPN13 HTR1E ADGRV1	1.12e-04	198	56	4	5fc25b008a4d8d6bec83923a16f64dd9e1ff1f2d
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	UNC13B PTPN13 VKORC1L1 ADGRV1	1.14e-04	199	56	4	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	distal-3-Epithelial-Club\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	UNC13B PTCHD1 PTPN13 TMEM184A	1.14e-04	199	56	4	1a0c3506df2438f5be40a8ea72effe5f8ebd35c4
ToppCell	healthy_donor\|World / Disease condition, Lineage, Cell class and subclass	JAK1 PIP4K2A KMT2E TMEM181	1.16e-04	200	56	4	afd4d5609adaa470e3d880f8be4a4d55e162b3d6
ToppCell	severe-MAIT\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MBOAT1 PIP4K2A KMT2E ADAM12	1.16e-04	200	56	4	1daf43f1bdd49585dce5e957820554d7f3c1bd4a
ToppCell	severe-MAIT\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	JAK1 PIP4K2A KMT2E ADAM12	1.16e-04	200	56	4	8a849d0ef244aa2666da2d31bd0731fb04e40911
ToppCell	Control-CD8+_T\|Control / Disease group and Cell class	PIP4K2A DZIP3 CHST12	2.40e-04	96	56	3	14e53fd2df39ac9d0b9cdc8b7ca2e95e53ac8bfe
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PIP4K2A ADGRV1 IL17RB	4.40e-04	118	56	3	d0dd5c882cd9e0a5eb0cb08e47877292126bd4ae
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PIP4K2A ADGRV1 IL17RB	4.40e-04	118	56	3	4283699cb3ca7a112faa07727dfdc0b0a67fb779
ToppCell	Club_cells-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	EYS MARK1 ACOX2	4.63e-04	120	56	3	7f85208f0455f3e634f8e7e81beea60b4ef1d2a5
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MYO5B SLIT1 OBSCN	4.86e-04	122	56	3	37612ad087d9c11d4a3466244ab36224de31930b
ToppCell	Posterior_cortex-Macroglia-OLIGODENDROCYTE\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MBOAT1 ADGRV1 IL17RB	5.09e-04	124	56	3	9f169fa17be1842a6bd83778ff30465a740edd5f
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE\|Thalamus / BrainAtlas - Mouse McCarroll V32	PIP4K2A ADGRV1 IL17RB	5.71e-04	129	56	3	b3cb0c10659d1216b8f7de3aa1f9aac101cb65dd
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Mme_Fam114a1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TNNI3K UNC13C CASZ1	6.24e-04	133	56	3	fc319644868078ea0f88a71d55f5e858c6848b50
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crhr2_Efemp1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TNNI3K UNC13C CRHR2	6.66e-04	136	56	3	e3a2425ba5ef538dbacab1479e682837ae42a888
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTPN13 RASA4 IL17RB	7.40e-04	141	56	3	d3ce2218bfa9750795d920e1ef162ea44efb2e66
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_Krt80\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYO5B OBSCN CASZ1	7.40e-04	141	56	3	40ef6d792e11fe10963d64eb0b606b90556c1a70
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crh_4930553C11Rik_\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TNNI3K TMEM255A CRHR2	7.40e-04	141	56	3	ad9a25569c142fb68ded34aeba0cd9be8124ce56
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-early_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLIT1 UNC13C TMEM255A	7.86e-04	144	56	3	1d05aa08603cba28c0c6511767e434c1f592a3aa
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTPN13 RASA4 IL17RB	7.86e-04	144	56	3	46177f0d6117e701bda86a99ac2a1b0e7ed66177
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-early_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLIT1 UNC13C TMEM255A	7.86e-04	144	56	3	d3f6f5da56794367ee3776bfd3a9dcf893efe0f0
ToppCell	COVID-19_Severe-MAIT\|World / disease group, cell group and cell class	EYS PTPN13 FITM1	8.02e-04	145	56	3	8d63f97812f63329ef9c940b291dc5a1c4d90690
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Glra3\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TNNI3K UNC13C TMEM255A	8.34e-04	147	56	3	50e86860a94be103092c40e39a172eac92372f0d
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIP4K2A RMC1 TMEM255A	8.34e-04	147	56	3	22c9605869dd2e789896cd2790ee8def2605de57
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIP4K2A RMC1 TMEM255A	8.34e-04	147	56	3	ac272595818d25c6b84b107555b3351e912a01a7
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_ALM_Trhr_Nefl\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	UNC13B SLIT1 UNC13C	8.68e-04	149	56	3	558a441804dbcd5b5f39a3b1933b48976711ff15
ToppCell	E18.5-samps-Epithelial-Epithelial-non_alveolar-Club_cell\|E18.5-samps / Age Group, Lineage, Cell class and subclass	CCN6 MBOAT1 TMEM184A	8.68e-04	149	56	3	82edfecb7981d8c336cf9da7aa7e2b3f7a017a3f
ToppCell	E18.5-samps-Epithelial-Epithelial-non_alveolar\|E18.5-samps / Age Group, Lineage, Cell class and subclass	CCN6 MBOAT1 TMEM184A	8.68e-04	149	56	3	14a01ae540db8a350ea26a350b2e6ce6c07639d9
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-NP-L6_NP_ALM_Trh\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	UNC13B RASA4 SLIT1	8.68e-04	149	56	3	fe9dff31a30dabd212d53d1295f9f13ff32cb217
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OPN3 SLIT1 CRHR2	8.85e-04	150	56	3	47ea08d7609e1d2382bf56ef9e5c767e3597cf93
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-NP\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	UNC13B SLIT1 UNC13C	8.85e-04	150	56	3	2ba55e51877e2e749cccdae7df5d885dc55b2587
ToppCell	COVID-19_Severe-MAIT\|COVID-19_Severe / disease group, cell group and cell class	EYS PTPN13 FITM1	8.85e-04	150	56	3	923ea7ecc0aa05fb0396082cd9c3d1594135f1e0
ToppCell	Basal_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	MARK1 UNC13C AKR1B1	9.19e-04	152	56	3	72499e4d2b374ef5f1621c89d94727ecf4bd4d5d
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crhr2_Efemp1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TNNI3K UNC13C CRHR2	9.54e-04	154	56	3	a2adaa4a6cd8708cd579b8efbeb4ff2131c5482e
ToppCell	E18.5-samps-Endothelial-Mature_fetal_endothelial-capillary_endothelial_Hpgd-CA4_high\|E18.5-samps / Age Group, Lineage, Cell class and subclass	RASA4 INTS3 CASZ1	9.54e-04	154	56	3	212c340a096a3a9669d1aebd61c045cf1402a868
ToppCell	COVID-19-Myeloid-Dendritic_cells\|COVID-19 / group, cell type (main and fine annotations)	HTR1E DOCK8 PIP4K2A	9.91e-04	156	56	3	a07a9096799e4ba663841c70035b4b32c1fda4f9
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D122\|Adult / Lineage, Cell type, age group and donor	UNC13B PTPN13 ADGRV1	1.01e-03	157	56	3	31d1bd9138c60e8485664ec4144f987226e3eef9
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF780B OBSCN CRHR1	1.03e-03	158	56	3	35f3082109a5930b89d14db3c8fa93148d3a5dd4
ToppCell	IIF-Lymphocyte-T_NK-ILC\|IIF / Disease, Lineage and Cell Type	CCN6 ERCC6 RASA4B	1.05e-03	159	56	3	55e4f21548f480ca414c00cbff5ec3b13bafd271
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPN13 MYO5B ADGRV1	1.05e-03	159	56	3	8680b054622f573a82b1625fb93c2d5db81d1034
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTCHD1 RASA4 PIP4K2A	1.05e-03	159	56	3	cdbccb83af6220bab300dfe56443ff69f6e2043a
ToppCell	COVID-19_Moderate-MAIT\|COVID-19_Moderate / disease group, cell group and cell class	PTPN13 ADAM12 IL17RB	1.05e-03	159	56	3	6d08d670c34eb6bb8ad5dad3293b3107c006236d
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TNNI3K UNC13C CASZ1	1.07e-03	160	56	3	dd16ca90feb3ae88b6409d6c278b4765da565514
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MBOAT1 PIP4K2A OBSCN	1.07e-03	160	56	3	237430af14830b38e58da8a4224036e5c6b71c5b
Drug	phenylalanyl corticotropin-releasing factor (12-41)	CRHR1 CRHR2	5.73e-06	2	55	2	ctd:C113202
Disease	treatment resistant depression, response to antidepressant	PTCHD1 OPN3 SLIT1	6.33e-06	21	51	3	EFO_0009854, GO_0036276
Disease	functional colonic disease (biomarker_via_orthology)	CRHR1 CRHR2	8.78e-06	3	51	2	DOID:3877 (biomarker_via_orthology)
Disease	mean arterial pressure, alcohol drinking	NAA25 SLIT1 ICE1 CASZ1	2.54e-05	98	51	4	EFO_0004329, EFO_0006340
Disease	diastolic blood pressure, alcohol drinking	NAA25 SLIT1 TNKS CASZ1	5.25e-05	118	51	4	EFO_0004329, EFO_0006336
Disease	systolic blood pressure, alcohol drinking	EYS NAA25 TNKS CASZ1	7.21e-05	128	51	4	EFO_0004329, EFO_0006335
Disease	irritable bowel syndrome (biomarker_via_orthology)	CRHR1 CRHR2	8.15e-05	8	51	2	DOID:9778 (biomarker_via_orthology)
Disease	neuroticism measurement	UNC13B IQCH DOCK8 PIP4K2A TNKS TAP2 CRHR1 TMEM255A	1.55e-04	909	51	8	EFO_0007660
Disease	pulse pressure measurement, alcohol drinking	ERCC6 TNKS CASZ1	2.45e-04	70	51	3	EFO_0004329, EFO_0005763
Disease	body weight	UNC13B TNNI3K EYS NAA25 BTD PIP4K2A SLIT1 ADGRV1 RMC1	2.78e-04	1261	51	9	EFO_0004338
Disease	behavioural disinhibition measurement	MBOAT1 PIP4K2A UNC13C	3.01e-04	75	51	3	EFO_0006946
Disease	Anorexia	CRHR1 CRHR2	4.40e-04	18	51	2	C0003123
Disease	hearing impairment	ERCC6 BTD ADGRV1	6.59e-04	98	51	3	C1384666
Disease	Pseudoaphakia	ERCC6 AKR1B1	7.89e-04	24	51	2	C0524524
Disease	Anhedonia	CRHR1 CRHR2	7.89e-04	24	51	2	C0178417
Disease	Lens Opacities	ERCC6 AKR1B1	7.89e-04	24	51	2	C1510497
Disease	indole-3-propionate measurement	SLIT1 UNC13C	1.00e-03	27	51	2	EFO_0010501
Disease	Autistic Disorder	PTCHD1 MARK1 BTD KMT2E	1.08e-03	261	51	4	C0004352
Disease	colorectal cancer (is_implicated_in)	JAK1 PTPN13 ERCC6	1.21e-03	121	51	3	DOID:9256 (is_implicated_in)
Disease	cervical cancer (is_implicated_in)	KMT2E TAP2	1.24e-03	30	51	2	DOID:4362 (is_implicated_in)
Disease	resting heart rate, chronic obstructive pulmonary disease	ADGRV1 CASZ1	1.24e-03	30	51	2	EFO_0000341, EFO_0004351
Disease	lung squamous cell carcinoma (is_marker_for)	PTPN13 ERCC6	1.78e-03	36	51	2	DOID:3907 (is_marker_for)
Disease	Cataract	ERCC6 AKR1B1	1.88e-03	37	51	2	C0086543
Disease	blood molybdenum measurement	NAA25 SLIT1	1.98e-03	38	51	2	EFO_0007582
Disease	Parkinson disease	UNC13B CCN6 PTCHD1 HIP1R	2.30e-03	321	51	4	MONDO_0005180
Disease	epilepsy	NAA25 TNKS	2.30e-03	41	51	2	EFO_0000474
Disease	neutrophil count	DOCK8 VKORC1L1 CHST12 UNC13C RMC1 KMT2E TAP2 CASZ1	2.40e-03	1382	51	8	EFO_0004833
Disease	autistic disorder (is_implicated_in)	PTCHD1 KMT2E	2.41e-03	42	51	2	DOID:12849 (is_implicated_in)
Disease	transient cerebral ischemia (biomarker_via_orthology)	JAK1 PTPN13 ERCC6	2.55e-03	157	51	3	DOID:224 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TVIHLQAAKVHCYYV	ACOX2	536	Q99424
HYHCLRTGCYFVTNI	CASZ1	1241	Q86V15
SQCTIQHDHVIYTIY	HTR1E	171	P28566
IALVGAHSHIYELAY	ADGRV1	3566	Q8WXG9
NYTVILGHCYYHGHV	ADAM12	111	O43184
HCHGILITSYSYIRL	ERCC6	616	Q03468
IDVGYRHIDCAHVYQ	AKR1B1	36	P15121
YVLHIPYCQSRAINH	OR2L3	161	Q8NG85
SSYYQPLVHLLCHEV	RASA4	266	O43374
YDQFVAICHPLHYTV	OR7A2P	121	Q8NGA2
SSYYQPLVHLLCHEV	RASA4B	266	C9J798
HYVFLQICRAHGIGY	IQCH	916	Q86VS3
YTYLRLIVDHHGTAQ	INTS3	211	Q68E01
SHKHIVYLYGVCVRD	JAK1	646	P23458
YVAVCQPLHYATIIH	OR2H2	121	O95918
VYLIHQHLCYCGVTF	EYS	451	Q5T1H1
VVYPSEICFHHTICY	IL17RB	336	Q9NRM6
LHYRIALVVNYLGHC	CRHR2	111	Q13324
IQDGTIHLYIYSIHS	KMT2E	421	Q8IZD2
NYFYHLLHIIIISGT	DZIP3	391	Q86Y13
VYIQQLVEGLHYLHS	OBSCN	6566	Q5VST9
GVIAHCYGHILYSIR	OPN3	216	Q9H1Y3
YLVAVGCEFNQVHYH	CCN6	116	O95389
LIQVIQDCSHLYHYT	HIP1R	216	O75146
DHNYIHALCRVYVGI	ICE1	1986	Q9Y2F5
QHGRNCLLASYVHYV	DOCK8	841	Q8NF50
LLCTVIYFHQYTHKV	FITM1	236	A5D6W6
LHTVHGTYYIQVCAL	BTD	446	P43251
YHVAVIINYLGHCIS	CRHR1	116	P34998
GYLTICHISRIYIFH	MBOAT1	116	Q6ZNC8
CHISRIYIFHYGILT	MBOAT1	121	Q6ZNC8
IVSAVQYCHQKYIVH	MARK1	166	Q9P0L2
KYHQYIVECHGITLL	PIP4K2A	161	P48426
DVSLIQHTLTCHQYY	PTPN13	666	Q12923
IQVYGYLLHTHLAGR	MOXD2P	381	A6NHM9
YVAVCQPLHYATIIH	OR2H1	121	Q9GZK4
YIDVSSCQDIIHLYH	TMEM255A	206	Q5JRV8
LEVHGVAILQSYLCY	PTCHD1	791	Q96NR3
CHQIYLHLRSYTVPQ	TMEM184A	71	Q6ZMB5
QYEHCYLHSQVVSVG	TAP2	536	Q03519
HLIVDDRHGAIYCYV	CHST12	156	Q9NRB3
SLQCLYYVREAHGIV	PREB	331	Q9HCU5
QHHLAVDLYHGVIYC	USP51	271	Q70EK9
VYQLYALCNHSGSVH	USP21	501	Q9UK80
VAPYHIQYTCLHENL	UNC13C	1356	Q8NB66
ATIYGQLYVLFLRHH	RMC1	216	Q96DM3
CAEIIVAHLGYLNYT	TMEM181	266	Q9P2C4
LHNACSYGHYEVTEL	TNKS	406	O95271
VAPYHVQYTCLHENL	UNC13B	736	O14795
VQYTCLHENLFHYLT	UNC13B	741	O14795
YHYQLIEHCQIHTGE	ZNF780A	316	O75290
YHYQLIQHCQIHTGG	ZNF780B	456	Q9Y6R6
AVCAAGILLSIYAYH	VKORC1L1	21	Q8N0U8
HIAVELYQGHVRVSY	SLIT1	1211	O75093
LHIAAYYGHEQVTRL	TNNI3K	171	Q59H18
THIKPIYNLYAISCH	USP6	1306	P35125
SNHIYTYCGIVLVAI	MYO5B	96	Q9ULV0
HIQHDTIGYLLTRYA	NAA25	536	Q14CX7