Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	neuropeptide binding	NPY4R2 NPY6R GALR1 NPY4R	2.53e-06	37	52	4	GO:0042923
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	NPY4R2 NPY6R NPY4R	2.71e-06	11	52	3	GO:0004983
GeneOntologyMolecularFunction	neuropeptide receptor activity	NPY4R2 NPY6R GALR1 NPY4R	1.09e-05	53	52	4	GO:0008188
GeneOntologyMolecularFunction	G protein-coupled receptor activity	NPY4R2 NPY6R GALR1 LPAR4 OR4A8 NPY4R GPR68 LPAR6 PTGER2 ADGRG4 NLRP6	1.37e-05	884	52	11	GO:0004930
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	NPY4R2 NPY6R GALR1 NPY4R NLRP6	2.46e-05	133	52	5	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	NPY4R2 NPY6R GALR1 NPY4R NLRP6	3.14e-05	140	52	5	GO:0001653
GeneOntologyMolecularFunction	pancreatic polypeptide receptor activity	NPY4R2 NPY4R	3.98e-05	4	52	2	GO:0001602
GeneOntologyMolecularFunction	lysophosphatidic acid receptor activity	LPAR4 LPAR6	6.62e-05	5	52	2	GO:0070915
GeneOntologyMolecularFunction	peptide YY receptor activity	NPY6R NPY4R	6.62e-05	5	52	2	GO:0001601
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	NPY4R2 NPY6R GALR1 LPAR4 FCER1G OR4A8 NPY4R GPR68 LPAR6 PTGER2 ADGRG4 NLRP6	1.45e-04	1353	52	12	GO:0004888
GeneOntologyMolecularFunction	peptide binding	NPY4R2 NPY6R GALR1 NPY4R DHCR24 NLRP6	1.71e-04	318	52	6	GO:0042277
GeneOntologyMolecularFunction	bioactive lipid receptor activity	LPAR4 LPAR6	7.80e-04	16	52	2	GO:0045125
GeneOntologyMolecularFunction	transporter activity	CACNA1D SIDT2 SLC8B1 SLCO1C1 SLC22A4 ABCC11 ATP11C SLC39A4 ATP9A AQP5	1.59e-03	1289	52	10	GO:0005215
GeneOntologyMolecularFunction	lipid transporter activity	SLCO1C1 ABCC11 ATP11C ATP9A	1.69e-03	196	52	4	GO:0005319
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ATP11C ATP9A	2.41e-03	28	52	2	GO:0140326
GeneOntologyMolecularFunction	phospholipid binding	LPAR4 PLA2G10 DYSF PIGU NLRP3 TULP1	2.90e-03	548	52	6	GO:0005543
GeneOntologyMolecularFunction	bile acid transmembrane transporter activity	SLCO1C1 ABCC11	3.54e-03	34	52	2	GO:0015125
GeneOntologyMolecularFunction	lipid binding	LPAR4 UGT1A6 PLA2G10 DYSF PIGU NLRP3 TULP1 NLRP6	3.79e-03	988	52	8	GO:0008289
GeneOntologyMolecularFunction	ATP-dependent activity	APPBP2 ABCC11 ATP11C ATP9A DNAH8 NLRP3	5.05e-03	614	52	6	GO:0140657
GeneOntologyMolecularFunction	molecular condensate scaffold activity	NLRP3 NLRP6	5.36e-03	42	52	2	GO:0140693
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCC11 ATP11C ATP9A DNAH8 NLRP3	5.69e-03	441	52	5	GO:0016887
GeneOntologyBiologicalProcess	regulation of secretion	CACNA1D SIDT2 SLC8B1 GALR1 FCER1G GPR68 PLA2G10 ATP9A DYSF NLRP6	2.65e-05	801	52	10	GO:0051046
GeneOntologyBiologicalProcess	secretion	CACNA1D SIDT2 SLC8B1 GALR1 FCER1G GPR68 SYNGR1 PLA2G10 ATP9A DYSF AQP5 NLRP6	3.98e-05	1221	52	12	GO:0046903
GeneOntologyBiologicalProcess	regulation of secretion by cell	CACNA1D SIDT2 SLC8B1 GALR1 FCER1G GPR68 PLA2G10 ATP9A DYSF	8.65e-05	740	52	9	GO:1903530
Domain	NPY4_rcpt	NPY4R2 NPY4R	6.74e-06	2	49	2	IPR001933
Domain	NPY_rcpt	NPY4R2 NPY4R	2.40e-04	9	49	2	IPR000611
Domain	P_typ_ATPase_c	ATP11C ATP9A	6.01e-04	14	49	2	IPR032630
Domain	P-type_ATPase_N	ATP11C ATP9A	6.01e-04	14	49	2	IPR032631
Domain	P-type_ATPase_IV	ATP11C ATP9A	6.01e-04	14	49	2	IPR006539
Domain	PhoLip_ATPase_C	ATP11C ATP9A	6.01e-04	14	49	2	PF16212
Domain	PhoLip_ATPase_N	ATP11C ATP9A	6.01e-04	14	49	2	PF16209
Domain	DAPIN	NLRP3 NLRP6	1.51e-03	22	49	2	PS50824
Domain	DAPIN	NLRP3 NLRP6	1.51e-03	22	49	2	IPR004020
Domain	PYRIN	NLRP3 NLRP6	1.51e-03	22	49	2	SM01289
Domain	PYRIN	NLRP3 NLRP6	1.51e-03	22	49	2	PF02758
Domain	NACHT	NLRP3 NLRP6	1.65e-03	23	49	2	PS50837
Domain	NACHT_NTPase	NLRP3 NLRP6	1.65e-03	23	49	2	IPR007111
Domain	GPCR_Rhodpsn_7TM	NPY4R2 GALR1 LPAR4 NPY4R GPR68 LPAR6 PTGER2	1.72e-03	670	49	7	IPR017452
Domain	7tm_1	NPY4R2 GALR1 LPAR4 NPY4R GPR68 LPAR6 PTGER2	1.82e-03	677	49	7	PF00001
Domain	G_PROTEIN_RECEP_F1_1	NPY4R2 GALR1 LPAR4 NPY4R GPR68 LPAR6 PTGER2	1.95e-03	685	49	7	PS00237
Domain	G_PROTEIN_RECEP_F1_2	NPY4R2 GALR1 LPAR4 NPY4R GPR68 LPAR6 PTGER2	2.04e-03	691	49	7	PS50262
Domain	GPCR_Rhodpsn	NPY4R2 GALR1 LPAR4 NPY4R GPR68 LPAR6 PTGER2	2.06e-03	692	49	7	IPR000276
Domain	-	ATP11C ATP9A	3.18e-03	32	49	2	2.70.150.10
Domain	-	ATP11C ATP9A	3.18e-03	32	49	2	3.40.1110.10
Domain	ATPase_P-typ_cyto_domN	ATP11C ATP9A	3.80e-03	35	49	2	IPR023299
Domain	ATPase_P-typ_P_site	ATP11C ATP9A	4.01e-03	36	49	2	IPR018303
Domain	P_typ_ATPase	ATP11C ATP9A	4.01e-03	36	49	2	IPR001757
Domain	ATPASE_E1_E2	ATP11C ATP9A	4.01e-03	36	49	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP11C ATP9A	4.24e-03	37	49	2	IPR008250
Domain	E1-E2_ATPase	ATP11C ATP9A	4.24e-03	37	49	2	PF00122
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	NPY6R GALR1 LPAR4 NPY4R GPR68 LPAR6 PTGER2	6.22e-06	260	39	7	M39397
Pathway	WP_GPCRS_NONODORANT	NPY6R GALR1 LPAR4 NPY4R GPR68 LPAR6 PTGER2	7.22e-06	266	39	7	MM15843
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	GALR1 LPAR4 NPY4R GPR68 LPAR6 PTGER2	2.67e-04	330	39	6	M18334
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	GALR1 LPAR4 NPY4R GPR68 LPAR6 PTGER2	2.81e-04	333	39	6	MM14963
Pathway	WP_NUCLEOTIDE_GPCRS	LPAR4 LPAR6	4.04e-04	11	39	2	M39422
Pathway	REACTOME_P2Y_RECEPTORS	LPAR4 LPAR6	4.04e-04	11	39	2	MM15049
Pathway	REACTOME_P2Y_RECEPTORS	LPAR4 LPAR6	4.84e-04	12	39	2	M10960
Pathway	WP_NUCLEOTIDE_GPCRS	LPAR4 LPAR6	4.84e-04	12	39	2	MM15953
Pathway	WP_10Q1121Q1123_COPY_NUMBER_VARIATION_SYNDROME	ARHGAP22 WDFY4 NLRP3	6.31e-04	61	39	3	M48077
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC8B1 SLCO1C1 SLC22A4 ABCC11 ATP11C SLC39A4 ATP9A AQP5	7.73e-04	736	39	8	M27287
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	GALR1 LPAR4 NPY4R LPAR6 PTGER2	8.68e-04	272	39	5	M13380
Pathway	REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS	LPAR4 LPAR6	8.73e-04	16	39	2	M6786
Pathway	REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS	LPAR4 LPAR6	8.73e-04	16	39	2	MM15050
Pathway	WP_GPCRS_PEPTIDE	NPY6R GALR1 NPY4R	9.43e-04	70	39	3	MM15959
Pathway	REACTOME_GPCR_LIGAND_BINDING	GALR1 LPAR4 NPY4R GPR68 LPAR6 PTGER2	1.08e-03	430	39	6	MM15160
Pathway	WP_CHOLESTEROL_SYNTHESIS_DISORDERS	FDPS DHCR24	1.11e-03	18	39	2	M45528
Pathway	WP_PEPTIDE_GPCRS	NPY6R GALR1 NPY4R	1.15e-03	75	39	3	M39696
Pathway	REACTOME_GPCR_LIGAND_BINDING	GALR1 LPAR4 NPY4R GPR68 LPAR6 PTGER2	1.58e-03	463	39	6	M507
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	NPY6R GALR1 NPY4R PTGER2	1.68e-03	186	39	4	MM15994
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC8B1 SLCO1C1 SLC22A4 ATP11C SLC39A4 ATP9A AQP5	2.37e-03	681	39	7	MM14985
Pathway	REACTOME_CHOLESTEROL_BIOSYNTHESIS	FDPS DHCR24	2.51e-03	27	39	2	MM14735
Pathway	REACTOME_CHOLESTEROL_BIOSYNTHESIS	FDPS DHCR24	2.51e-03	27	39	2	M16227
Pubmed	Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes.	LPAR4 LPAR6	2.37e-06	2	54	2	26714589
Pubmed	Aggregatibacter actinomycetemcomitans targets NLRP3 and NLRP6 inflammasome expression in human mononuclear leukocytes.	NLRP3 NLRP6	2.37e-06	2	54	2	22503597
Pubmed	Mouse germ cell-less as an essential component for nuclear integrity.	GMCL1 GMCL2	2.37e-06	2	54	2	12556490
Pubmed	Desiccating stress worsens alkali burn injury by magnifying caspase-8-induced imbalance of NLRP3 and NLRP6.	NLRP3 NLRP6	2.37e-06	2	54	2	28479336
Pubmed	Identification of mammalian orthologs associates PYPAF5 with distinct functional roles.	NLRP3 NLRP6	2.37e-06	2	54	2	12633874
Pubmed	Candida albicans SC5314 inhibits NLRP3/NLRP6 inflammasome expression and dampens human intestinal barrier activity in Caco-2 cell monolayer model.	NLRP3 NLRP6	2.37e-06	2	54	2	31629100
Pubmed	NLRP3 and NLRP6 expression in pterygium and normal conjunctiva and their relationship with pterygium formation and recurrence.	NLRP3 NLRP6	2.37e-06	2	54	2	35068231
Pubmed	Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells.	GMCL1 GMCL2	2.37e-06	2	54	2	10448096
Pubmed	Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact.	LPAR4 LPAR6	2.37e-06	2	54	2	28854359
Pubmed	Stage-specific expression of mouse germ cell-less-1 (mGCL-1), and multiple deformations during mgcl-1 deficient spermatogenesis leading to reduced fertility.	GMCL1 GMCL2	2.37e-06	2	54	2	15700541
Pubmed	Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor.	GMCL1 GMCL2	7.09e-06	3	54	2	9878064
Pubmed	Aberrant expression of NLRP3, NLRC4 and NLRP6 inflammasomes in patients with primary immune thrombocytopenia.	NLRP3 NLRP6	7.09e-06	3	54	2	30802690
Pubmed	Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.	NPY4R2 NPY4R	7.09e-06	3	54	2	8643460
Pubmed	Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells.	LPAR4 LPAR6	7.09e-06	3	54	2	25849892
Pubmed	NLRP6 controls pulmonary inflammation from cigarette smoke in a gut microbiota-dependent manner.	AQP5 NLRP6	1.42e-05	4	54	2	38146368
Pubmed	Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less.	GMCL1 GMCL2	1.42e-05	4	54	2	12927808
Pubmed	A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis.	FCER1G PLA2G10	1.42e-05	4	54	2	20432503
Pubmed	Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.	NPY4R2 NPY4R	1.42e-05	4	54	2	7592911
Pubmed	Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4.	LPAR4 LPAR6	1.42e-05	4	54	2	31335323
Pubmed	Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts.	LPAR6 PLA2G10 PTGER2	1.87e-05	33	54	3	39002541
Pubmed	Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.	NLRP3 NLRP6	2.36e-05	5	54	2	25828455
Pubmed	NLRP6 negatively regulates pulmonary host defense in Gram-positive bacterial infection through modulating neutrophil recruitment and function.	NLRP3 NLRP6	2.36e-05	5	54	2	30248149
Pubmed	Molecular mechanism of lysophosphatidic acid-induced hypertensive response.	LPAR4 LPAR6	2.36e-05	5	54	2	30804442
Pubmed	Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.	NPY4R2 NPY4R	2.36e-05	5	54	2	7493937
Pubmed	Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment.	NLRP3 NLRP6	2.36e-05	5	54	2	27779193
Pubmed	Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system.	NLRP3 NLRP6	2.36e-05	5	54	2	23997220
Pubmed	Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.	NLRP3 NLRP6	2.36e-05	5	54	2	26638072
Pubmed	Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig.	NPY6R NPY4R	2.36e-05	5	54	2	10720571
Pubmed	LPA1 , LPA2 , LPA4 , and LPA6 receptor expression during mouse brain development.	LPAR4 LPAR6	3.54e-05	6	54	2	30847983
Pubmed	Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes.	NLRP3 NLRP6	3.54e-05	6	54	2	26253422
Pubmed	Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells.	LPAR4 LPAR6	3.54e-05	6	54	2	33317583
Pubmed	Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells.	LPAR4 LPAR6	3.54e-05	6	54	2	11004484
Pubmed	Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.	GPR68 PLA2G10	3.54e-05	6	54	2	15927955
Pubmed	NLRC4 suppresses melanoma tumor progression independently of inflammasome activation.	NLRP3 NLRP6	3.54e-05	6	54	2	27617861
Pubmed	Identification of a mouse germ cell-less homologue with conserved activity in Drosophila.	GMCL1 GMCL2	3.54e-05	6	54	2	10727854
Pubmed	Acidic environment augments FcεRI-mediated production of IL-6 and IL-13 in mast cells.	FCER1G GPR68	3.54e-05	6	54	2	26196745
Pubmed	Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice.	NPY6R NPY4R	4.94e-05	7	54	2	10698177
Pubmed	Structural, expression, and evolutionary analysis of mouse CIAS1.	NLRP3 NLRP6	4.94e-05	7	54	2	15302403
Pubmed	AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.	NLRP3 NLRP6	4.94e-05	7	54	2	19158675
Pubmed	Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements.	ATP9A DYSF	4.94e-05	7	54	2	18454193
Pubmed	The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function.	NLRP3 NLRP6	4.94e-05	7	54	2	31420376
Pubmed	LPA2 promotes neuronal differentiation and neurite formation in neocortical development.	LPAR4 LPAR6	4.94e-05	7	54	2	35151977
Pubmed	Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses.	FCER1G NLRP3	6.59e-05	8	54	2	21059925
Pubmed	FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes.	FCER1G NLRP3	6.59e-05	8	54	2	27365531
Pubmed	Plant Lectins Activate the NLRP3 Inflammasome To Promote Inflammatory Disorders.	NLRP3 NLRP6	8.46e-05	9	54	2	28087670
Pubmed	Human metabolic individuality in biomedical and pharmaceutical research.	UGT1A6 SLC22A4 REV3L	9.76e-05	57	54	3	21886157
Pubmed	Shaping of Intestinal Microbiota in Nlrp6- and Rag2-Deficient Mice Depends on Community Structure.	NLRP3 NLRP6	1.06e-04	10	54	2	29281837
Pubmed	The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection.	NLRP3 NLRP6	1.06e-04	10	54	2	30392956
Pubmed	The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease.	ATP11C ATP9A	1.06e-04	10	54	2	15919184
Pubmed	The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis.	NLRP3 NLRP6	1.06e-04	10	54	2	24875775
Pubmed	Lysophosphatidic acid induces neurite branch formation through LPA3.	LPAR4 LPAR6	1.06e-04	10	54	2	22465231
Pubmed	Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock.	NLRP3 NLRP6	1.29e-04	11	54	2	26572062
Pubmed	IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.	NLRP3 NLRP6	1.29e-04	11	54	2	23075849
Pubmed	Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY.	NPY6R NPY4R	1.55e-04	12	54	2	9417917
Pubmed	Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less).	GMCL1 GMCL2	1.55e-04	12	54	2	11591818
Pubmed	Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.	CACNA1D DYSF	1.55e-04	12	54	2	23715556
Pubmed	Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.	CACNA1D SEZ6L	1.55e-04	12	54	2	21901158
Pubmed	ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.	ATP11C ATP9A	1.55e-04	12	54	2	21914794
Pubmed	NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.	NLRP3 NLRP6	1.55e-04	12	54	2	21565393
Pubmed	Non-canonical inflammasome activation targets caspase-11.	NLRP3 NLRP6	1.55e-04	12	54	2	22002608
Pubmed	Differential expression of putative transbilayer amphipath transporters.	ATP11C ATP9A	1.83e-04	13	54	2	11015572
Pubmed	The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.	NLRP3 NLRP6	1.83e-04	13	54	2	32758418
Pubmed	Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.	NLRP3 NLRP6	1.83e-04	13	54	2	28636595
Pubmed	The genetics of NOD-like receptors in Crohn's disease.	NLRP3 NLRP6	2.13e-04	14	54	2	20403135
Pubmed	NALPs: a novel protein family involved in inflammation.	NLRP3 NLRP6	2.13e-04	14	54	2	12563287
Pubmed	Lysophospholipid receptor nomenclature review: IUPHAR Review 8.	LPAR4 LPAR6	2.45e-04	15	54	2	24602016
Pubmed	Screening of the interaction between xenobiotic transporters and PDZ proteins.	SLCO1C1 SLC22A4	2.45e-04	15	54	2	15553237
Pubmed	Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages.	GMCL1 GMCL2	2.45e-04	15	54	2	17010969
Pubmed	A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion.	NLRP3 NLRP6	2.45e-04	15	54	2	27339979
Pubmed	Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing.	ATP9A DYSF	2.45e-04	15	54	2	19436707
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	LPAR4 GPR68 ADGRG4	2.57e-04	79	54	3	12679517
Pubmed	Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis.	FCER1G NLRP3	2.80e-04	16	54	2	31169521
Pubmed	Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.	NLRP3 NLRP6	3.17e-04	17	54	2	22297845
Pubmed	Stable association between G alpha(q) and phospholipase C beta 1 in living cells.	LPAR4 GPR68 LPAR6	4.43e-04	95	54	3	16754659
Pubmed	siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.	REV3L USP1	7.51e-04	26	54	2	23435420
Pubmed	Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.	PLA2G10 PTGER2	8.10e-04	27	54	2	23624557
Pubmed	Determination of genetic predisposition to patent ductus arteriosus in preterm infants.	DHCR24 ABCC11 PTGER2	1.08e-03	129	54	3	19336370
Pubmed	A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.	FDPS DHCR24	1.52e-03	37	54	2	26108225
Interaction	YIPF3 interactions	SIDT2 SLC22A4 SYNGR1 ALG10 ATP9A PIGU	4.47e-06	186	47	6	int:YIPF3
Interaction	ALG10 interactions	LPAR6 SLC22A4 ALG10 SLC39A4	5.09e-06	49	47	4	int:ALG10
Interaction	P2RY2 interactions	DHCR24 SLC39A4 ATP9A PIGU NLRP3	6.17e-06	112	47	5	int:P2RY2
Interaction	PIGO interactions	SIDT2 SLC22A4 SYNGR1 SLC39A4	1.58e-05	65	47	4	int:PIGO
Interaction	SPPL2B interactions	SIDT2 DHCR24 ALG10 SLC39A4 ATP9A PIGU	1.62e-05	233	47	6	int:SPPL2B
Interaction	GAGE12B interactions	GMCL1 GMCL2	3.18e-05	4	47	2	int:GAGE12B
Interaction	GAGE12I interactions	GMCL1 GMCL2	3.18e-05	4	47	2	int:GAGE12I
Interaction	TSPAN15 interactions	LPAR6 DHCR24 SLC22A4 ALG10 ATP9A PIGU	4.19e-05	276	47	6	int:TSPAN15
Interaction	GPRC5C interactions	APPBP2 SLC22A4 SYNGR1 SLC39A4	9.69e-05	103	47	4	int:GPRC5C
Interaction	ATP8B2 interactions	LPAR6 SLC22A4 SLC39A4	1.37e-04	43	47	3	int:ATP8B2
Interaction	CHRNA10 interactions	SIDT2 PIGU	1.90e-04	9	47	2	int:CHRNA10
Interaction	KDELR3 interactions	LPAR6 SLC22A4 SLC39A4	2.29e-04	51	47	3	int:KDELR3
Cytoband	Ensembl 112 genes in cytogenetic band chr10q11	ARHGAP22 NPY4R2 NPY4R WDFY4	7.34e-05	188	54	4	chr10q11
Cytoband	2p13.3	GMCL1 DYSF	8.34e-04	36	54	2	2p13.3
GeneFamily	Lysophosphatidic acid receptors	LPAR4 LPAR6	6.42e-05	6	38	2	205
GeneFamily	Neuropeptide receptors	NPY6R NPY4R	1.92e-04	10	38	2	854
GeneFamily	ATPase phospholipid transporting	ATP11C ATP9A	4.44e-04	15	38	2	1210
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP3 NLRP6	1.25e-03	25	38	2	994
GeneFamily	NLR family	NLRP3 NLRP6	1.25e-03	25	38	2	666
GeneFamily	Solute carriers	SLC8B1 SLCO1C1 SLC22A4 SLC39A4	9.22e-03	395	38	4	752
ToppCell	PND10-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC8B1 SPOUT1 GPR68 WDFY4 NLRP3	1.42e-06	159	54	5	807ee55fe0d3645fbfb98f641dd0a0555b847cf5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	FCER1G SLC22A4 DYSF PTGER2 NLRP3	3.49e-06	191	54	5	9f0d956e9a14b1cd2c20a52639c6b22c349b377e
ToppCell	medial-Hematologic-Myeloid_Dendritic_Type_1\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ARHGAP22 GALR1 WDFY4 NLRP3 SEZ6L	4.06e-06	197	54	5	5bd2f32137fd849931e52093d630d2e7e27daf4f
ToppCell	medial-Hematologic-Myeloid_Dendritic_Type_1-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ARHGAP22 GALR1 WDFY4 NLRP3 SEZ6L	4.06e-06	197	54	5	d9baa0be469fd8737a74b5078d30ce7d66759160
ToppCell	medial-2-Hematologic-Myeloid_Dendritic_Type_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ARHGAP22 GALR1 WDFY4 NLRP3 SEZ6L	4.06e-06	197	54	5	3c1147857de6a7ab6b0cf77f5a6364d4c8669693
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP22 FCER1G LPAR6 WDFY4 NLRP3	4.06e-06	197	54	5	363ae03310f63a586ba3cea2a59f35d5a335a54e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FCER1G SLC22A4 DYSF PTGER2 NLRP3	4.27e-06	199	54	5	c40cb51c738b15d2761a50cfc8415a31a673be7f
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP22 FCER1G LPAR6 WDFY4 NLRP3	4.37e-06	200	54	5	179afc4bee7a2fd85a3b5dadf32544a63807c164
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_other\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP22 FCER1G LPAR6 WDFY4 NLRP3	4.37e-06	200	54	5	ad52b38df5c71f28829b04cd0e6b97f0f9f7610a
ToppCell	LPS_only-Myeloid-Dendritic_cells-mDC\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP22 GMCL2 WDFY4 NLRP3	3.05e-05	147	54	4	26bd9d89e2e7b841cc18030bb7cebb642b987183
ToppCell	P28-Epithelial-epithelial_progenitor_cell-epi_progenitor\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ARHGAP22 SYNGR1 SLC39A4 AQP5	3.75e-05	155	54	4	be575a0096415705dba425002247289ff8f89474
ToppCell	356C-Epithelial_cells-Epithelial-D_(AT2)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	NT5DC4 DHCR24 KNDC1 ZMYM4	4.89e-05	166	54	4	2e4cb4056e6b0c43290a5588ff525f5f05b8beee
ToppCell	356C-Epithelial_cells-Epithelial-D_(AT2)\|356C / Donor, Lineage, Cell class and subclass (all cells)	NT5DC4 DHCR24 KNDC1 ZMYM4	4.89e-05	166	54	4	eb8d972326a734549675307e411fc795af66da70
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FCER1G SPOUT1 SYNGR1 PTGER2	5.01e-05	167	54	4	e242827999caad08b0894d88ab97bc1df41b7650
ToppCell	facs-Marrow-KLS-18m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHPN1 ARHGAP22 SLC8B1 WDFY4	5.62e-05	172	54	4	979fd7b435f59b8a4d290a809cf76147d4c63d48
ToppCell	facs-Marrow-KLS-18m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHPN1 ARHGAP22 SLC8B1 WDFY4	5.62e-05	172	54	4	f4d7f416802218ce56408fa4cb8a555d846bc85b
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 FCER1G WDFY4 NLRP3	6.14e-05	176	54	4	926ed37e636fe4dd3a18731cea15761f0c2c285a
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_macrophage_(16)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ARHGAP22 FCER1G WDFY4 NLRP3	6.14e-05	176	54	4	98176bf3c961d5262593e2d5d002836adb010e13
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	FCER1G DYSF WDFY4 SEZ6L	6.28e-05	177	54	4	3a94ee9b58ebdbbc75e00954cf1f6922f88f8f88
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SIDT2 FCER1G UGT1A6 NLRP3	6.42e-05	178	54	4	aa9f68a66e292f331faef881bbd0d028f0f2b0c5
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FDPS DHCR24 DYSF PKHD1L1	7.30e-05	184	54	4	3b0389c3a5a16697de860e98ebc48ed39ede646f
ToppCell	Dendritic_Cells-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	ARHGAP22 FCER1G LPAR6 NLRP3	7.61e-05	186	54	4	1d52912bd17e232cf39b2423a4d93585c164ba34
ToppCell	droplet-Lung-LUNG-1m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHPN1 ATP9A DYSF PKHD1L1	7.77e-05	187	54	4	9c9ae8725905ba0cfe407878006ed06c2480fb72
ToppCell	droplet-Lung-LUNG-1m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHPN1 ATP9A DYSF PKHD1L1	7.77e-05	187	54	4	9e9460e57cdc9cd0a0de2866b140e06d0bc19a8f
ToppCell	control-Myeloid-Resident_Macrophage\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ARHGAP22 FCER1G NLRP3 SEZ6L	7.93e-05	188	54	4	9bcd6a83da912d136745d1abcb34b3735141048c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 FCER1G WDFY4 NLRP3	7.93e-05	188	54	4	0d7296ad26e97ad91c6927a6cfe4e6e70a74c5a6
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FCER1G SLC22A4 DYSF NLRP3	8.10e-05	189	54	4	235c24eeab5139f5821fccd5c879d8787682f4ef
ToppCell	facs-Marrow-KLS-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP22 SLC8B1 FDPS SLC22A4	8.10e-05	189	54	4	b28a0e2d5a5f512f9b137b162b195bdc3d5ee9ba
ToppCell	NS-control-d_0-4-Myeloid-Resident_Macrophage\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGAP22 FCER1G NLRP3 SEZ6L	8.26e-05	190	54	4	5215d2a4ac0475c621f6e6c477916149e2f73d64
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GXYLT2 SIDT2 ZMYM4 SEZ6L	8.43e-05	191	54	4	9214655dca96d766737c9f30b624d7fe7050342e
ToppCell	10x5'-Lung-Myeloid_Monocytic-Nonclassical_monocytes\|Lung / Manually curated celltypes from each tissue	SIDT2 FCER1G KNDC1 SEZ6L	8.43e-05	191	54	4	a862a571625ab7238589ff201e5954f602c3bd7e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 LPAR6 WDFY4 NLRP3	8.60e-05	192	54	4	86d792682ba51696f503c79625dd20f87bcf651f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 LPAR6 WDFY4 NLRP3	8.60e-05	192	54	4	d0ad6a205ad50a3c523fa68676996b289eabc5de
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-H_(AT1)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	ARHGAP22 LPAR6 SYNGR1 AQP5	8.60e-05	192	54	4	7a6dd2ae217b8f8e460d47ad128904408299458c
ToppCell	3'_v3-bone_marrow-Myeloid_Monocytic-Nonclassical_monocytes\|bone_marrow / Manually curated celltypes from each tissue	SIDT2 FCER1G KNDC1 SEZ6L	8.78e-05	193	54	4	dc309c249d569e93dc2b154e002212a6eee44497
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 FCER1G WDFY4 NLRP3	8.78e-05	193	54	4	bd08555f02db8bc903caacae57e80bb91e2556ce
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM3-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCER1G LPAR6 DYSF NLRP3	8.78e-05	193	54	4	93ba635ed69fec9286fe7636b9d258f3d93a22c3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 FCER1G WDFY4 NLRP3	8.78e-05	193	54	4	374d0526a071e973c3f43b4564f78f6933bb67ed
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCER1G LPAR6 DYSF NLRP3	8.78e-05	193	54	4	6dfdeb793cb5ad6412b6f808b5687a4e74b6ec65
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 FCER1G WDFY4 NLRP3	8.95e-05	194	54	4	96f16bcd393a0d3f8df479b172b5360ae5a1e663
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM3-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FCER1G LPAR6 DYSF NLRP3	8.95e-05	194	54	4	e455cb469157c044126f9b0b308957d4ee1e608b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 FCER1G WDFY4 NLRP3	8.95e-05	194	54	4	badefcec2af86cbcd97305f4843e84db0f3ebc66
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 LPAR6 WDFY4 NLRP3	8.95e-05	194	54	4	c95d5c4ad0210ebd672926558cc8331e6396a854
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM3\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FCER1G LPAR6 DYSF NLRP3	8.95e-05	194	54	4	e0cfd18a7ea2251163d61312b9397f8a518c8c51
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 FCER1G WDFY4 NLRP3	9.13e-05	195	54	4	91a3c439f10c03c5d51d904f512b6a08040edc76
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FCER1G LPAR6 WDFY4 NLRP3	9.13e-05	195	54	4	c14d730dd5c94247bc09711eaa5a53bd5a5957be
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 FCER1G WDFY4 NLRP3	9.13e-05	195	54	4	09df40ff9b493170861b3f6e57a942a834655b5c
ToppCell	severe_COVID-19-Non-classical_Monocyte\|severe_COVID-19 / disease group, cell group and cell class (v2)	SIDT2 FCER1G KNDC1 SEZ6L	9.32e-05	196	54	4	34c1c74cad5e23196e86cfd6f19c836fe57b2264
ToppCell	Mild_COVID-19-Myeloid-MoAM3\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	FCER1G LPAR6 DYSF NLRP3	9.32e-05	196	54	4	9faad17aa0b6af5a8ec2dadf7d70b9209d658072
ToppCell	COVID-19-lung-Macrophage_metabolically_active\|lung / Disease (COVID-19 only), tissue and cell type	ARHGAP22 FCER1G LPAR6 WDFY4	9.32e-05	196	54	4	a753d76d764c181eecb0e17a794a2e7d0ff70136
ToppCell	Skin-Leukocytes\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	FCER1G PTGER2 WDFY4 NLRP3	9.32e-05	196	54	4	e327a377c70d17912f5fd2a3529f4e88b147c6c7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 FCER1G WDFY4 NLRP3	9.32e-05	196	54	4	291c59b609985167c98a40d4e2caeea2fad74941
ToppCell	3'_v3-Lung-Myeloid_Monocytic-Nonclassical_monocytes\|Lung / Manually curated celltypes from each tissue	SIDT2 FCER1G KNDC1 NLRP3	9.32e-05	196	54	4	7fe97109a5a06b35fc081a85f341ea78da131323
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 LPAR6 WDFY4 NLRP3	9.32e-05	196	54	4	cbc727b55b6433a701b1a331028a49960fcee6ee
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FCER1G SLC22A4 PTGER2 NLRP3	9.50e-05	197	54	4	280804810041783f1b7704914b62ffefbb0d88f6
ToppCell	distal-3-Hematologic-IGSF21+_Dendritic\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ARHGAP22 FCER1G LPAR6 NLRP3	9.50e-05	197	54	4	52e9dc35dd8cc2605fa4894bb16bb5c6086faa76
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 FCER1G WDFY4 NLRP3	9.69e-05	198	54	4	96883ad8e189a46ed5b7eaafc0543e53682d26ed
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 FCER1G LPAR6 WDFY4	9.69e-05	198	54	4	d3e19705f92c665b5b319569000f22913135f331
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP22 LPAR6 WDFY4 NLRP3	9.69e-05	198	54	4	c7dbf24caae5c4ef285845d13055de9e07281bb3
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP22 FCER1G LPAR6 WDFY4	9.69e-05	198	54	4	732a43061d75bc5e1cf23f5056b72cd10c926668
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 FCER1G WDFY4 NLRP3	9.69e-05	198	54	4	623f9d64c9e800d2d7f623392bf2f22b563f0249
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 FCER1G WDFY4 NLRP3	9.88e-05	199	54	4	04adf46975aa4194ea40c7480f8a517def5d929c
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FCER1G LPAR6 WDFY4 NLRP3	9.88e-05	199	54	4	f34c15df58fbdc6c90e30800e26fabbf828ad10b
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP22 FCER1G WDFY4 NLRP3	9.88e-05	199	54	4	744b63fba33b176ab7dde11646ccb313665505f7
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC8B1 FCER1G LRRC72 NLRP3	9.88e-05	199	54	4	951c2ea5af4756832c2adcec3ee70a7e36331a4e
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intermediate\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP22 FCER1G WDFY4 NLRP3	9.88e-05	199	54	4	54167894a16e975d0541cbe3e515bcfa183044f6
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD14\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP22 FCER1G WDFY4 NLRP3	9.88e-05	199	54	4	1413156b7be5373fd02bbe39ec50ccfe165fa6d1
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 FCER1G LPAR6 WDFY4	9.88e-05	199	54	4	ca0f6526ba0dcf8789dd3b583291519626427f2f
ToppCell	Tracheal-NucSeq-Immune_Myeloid\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP22 FCER1G WDFY4 NLRP3	1.01e-04	200	54	4	ad7ae5106141669b353800fece833b3cd5bdccee
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_other\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP22 FCER1G WDFY4 NLRP3	1.01e-04	200	54	4	f3dc07a7cc8cf041da8fe610d21af595818cf2d8
ToppCell	Sigmoid-(4)_Monocyte\|Sigmoid / shred on region, Cell_type, and subtype	FCER1G SLC22A4 DYSF NLRP3	1.01e-04	200	54	4	7f3920a0434d5199c6c8f0b3064a305bb0d87b60
ToppCell	Sigmoid-Monocyte-Monocyte\|Sigmoid / Region, Cell class and subclass	FCER1G SLC22A4 DYSF NLRP3	1.01e-04	200	54	4	010ca36970cb8894bdbca08779c0ecf56be22fc9
ToppCell	Sigmoid-Monocyte\|Sigmoid / Region, Cell class and subclass	FCER1G SLC22A4 DYSF NLRP3	1.01e-04	200	54	4	c41bd6ec0f2262fce5cadb37a400d487e6662f49
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD14\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP22 FCER1G WDFY4 NLRP3	1.01e-04	200	54	4	5432bdf495431cd26f6e4cd585100f3652588913
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP22 LPAR6 WDFY4 NLRP3	1.01e-04	200	54	4	78d75d381cb2b9a4c9eb7c32a07b014eaee39195
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Monocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FCER1G WDFY4 NLRP3 SEZ6L	1.01e-04	200	54	4	8872d5fa101d413fb43b4231d476878678543035
ToppCell	Sigmoid-(4)_Monocyte-(40)_Monocyte\|Sigmoid / shred on region, Cell_type, and subtype	FCER1G SLC22A4 DYSF NLRP3	1.01e-04	200	54	4	576c0a1098e6a934448705de3673ef798fcf1b26
ToppCell	Bronchial-NucSeq-Immune_Myeloid\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP22 FCER1G WDFY4 NLRP3	1.01e-04	200	54	4	2f5b71e55c2de0e77fdae6667eb57f333acc6cd1
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	UGT1A6 C10orf126 WDFY4	3.22e-04	110	54	3	f626f0fdd1bff9c4970af14524ebdbdad8b67178
ToppCell	LPS_only-Myeloid-Dendritic_cells-Monocytes-Macrophages\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP22 SLC8B1 WDFY4	3.40e-04	112	54	3	9801227fe5a6f5ae1b6c5a9e7fa7f35c4c52efe1
ToppCell	Posterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	FCER1G SLC39A4 NLRP3	4.90e-04	127	54	3	0750743574c2fca8df07e11d73e8b94579209609
ToppCell	LPS-IL1RA-Myeloid-Monocytes,_Macrophages-Neutrophils\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC8B1 WDFY4 NLRP3	6.38e-04	139	54	3	505bf5a483fc2ba69377db9850c3b26ab2f416d1
ToppCell	356C-Epithelial_cells-Epithelial-B_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SPOUT1 FDPS KNDC1	6.38e-04	139	54	3	aefcfda2b2db302ce4b3d2a09f767be0b1c3ac6c
ToppCell	356C-Epithelial_cells-Epithelial-B_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SPOUT1 FDPS KNDC1	6.38e-04	139	54	3	b9c2dfab119ac0efdf931bb2910e82bccdb4e48d
ToppCell	10x5'-blood-Myeloid_Mac\|blood / Manually curated celltypes from each tissue	CACNA1D ABCC11 NLRP3	7.65e-04	148	54	3	1ae2d7475e030e2de49940f3287b02953dbf3c65
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP22 WDFY4 SEZ6L	7.65e-04	148	54	3	12fa2c4922f03803006c606b1b16e79441e3bb13
ToppCell	10x5'-blood-Myeloid_Mac-Intermediate_macrophages\|blood / Manually curated celltypes from each tissue	CACNA1D ABCC11 NLRP3	7.65e-04	148	54	3	b801f38d249a02c4ceceb242cabbbc88418e5fd1
ToppCell	LPS_only-Myeloid-Dendritic_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP22 GMCL2 WDFY4	7.65e-04	148	54	3	cb9365663f9cba35d47b5dd9079f42e88b70d915
ToppCell	Substantia_nigra-Hematopoietic-MICROGLIA\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	FCER1G WDFY4 NLRP3	7.95e-04	150	54	3	d44c02402e59a45e40b8fffbe71284032b5e7c92
ToppCell	Substantia_nigra-Hematopoietic-MICROGLIA-MI2(C1qb)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	FCER1G WDFY4 NLRP3	7.95e-04	150	54	3	e020dbcf85c0ba7ad667b8bbeb6bbcfc135c9bb7
ToppCell	Substantia_nigra-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	FCER1G WDFY4 NLRP3	7.95e-04	150	54	3	edbc1d29d213bf5908592135700e0d80e123c923
ToppCell	Substantia_nigra-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	FCER1G WDFY4 NLRP3	7.95e-04	150	54	3	01c526e1e3007e71e416c317549fddd2919b14e9
ToppCell	Substantia_nigra-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	FCER1G WDFY4 NLRP3	7.95e-04	150	54	3	b7f5bf9af7ed50aad4da1c71d37b8b9709e6ce85
ToppCell	Hippocampus-Hematopoietic\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FCER1G WDFY4 NLRP3	8.11e-04	151	54	3	81b2189afd72658f7e2539b856ba79cd49340215
ToppCell	E16.5-samps-Myeloid-Fetal_macrophage-Proliferative_Myeloid\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FCER1G WDFY4 NLRP3	8.26e-04	152	54	3	e427758a6e39052616a0d8ecec0c1299e81d1d3c
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCER1G WDFY4 NLRP3	8.58e-04	154	54	3	ad6cfd7fc02f4201863dc8e12e353395c86c5fdb
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-24m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCER1G GPR68 WDFY4	8.74e-04	155	54	3	d2e489a08b4e711bd2ed483dcc4da7dbbaa4feea
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-24m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCER1G GPR68 WDFY4	8.74e-04	155	54	3	cb456d6f13bfb5cb400c0840a0ab6ba4616dcf37
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-24m-Myeloid-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCER1G GPR68 WDFY4	8.74e-04	155	54	3	a547fdcd974b0813ce6c8cccfec9fff74cac2d1a
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	GPR68 ABCC11 SEZ6L	8.74e-04	155	54	3	d76a0f99ec35560d18820f9c92b69364ef2250e3
Disease	metabolite measurement	ARHGAP22 FCER1G FDPS UGT1A6 SLC22A4 REV3L WDFY4	5.45e-05	560	52	7	EFO_0004725
Disease	histidine betaine (hercynine) measurement	UGT1A6 SLC22A4	1.66e-04	11	52	2	EFO_0800972
Disease	bilirubin measurement	SLCO1C1 UGT1A6 SLC22A4 REV3L NLRP3	1.07e-03	442	52	5	EFO_0004570
Disease	Drug Allergy	FCER1G NLRP3	1.75e-03	35	52	2	C0013182
Disease	non-alcoholic fatty liver disease (implicated_via_orthology)	SIDT2 NLRP3	1.85e-03	36	52	2	DOID:0080208 (implicated_via_orthology)
Disease	total cholesterol measurement, triglyceride measurement, low density lipoprotein cholesterol measurement, high density lipoprotein cholesterol measurement	TRAM2 PIGU	3.40e-03	49	52	2	EFO_0004530, EFO_0004574, EFO_0004611, EFO_0004612

Protein segments in the cluster

Peptide	Gene	Start	Entry
VFNIYIPNYILKFCL	ADGRG4	2841	Q8IZF6
LLDYGFYLLNVDNIC	APPBP2	291	Q92624
LAAILYFYLLFPNSL	AQP5	216	P55064
LIFPLYICCNFLYIS	GMCL1	496	Q96IK5
FQYCLPLGFILVCYA	NPY4R	221	P50391
LYCREQPYYLNLIEL	FDPS	211	P14324
CFVPYNSVLFLYALV	LPAR4	261	Q99677
LFCSLPLLDYGQYVQ	PTGER2	166	P43116
EPQLCYILDAILFLY	FCER1G	21	P30273
LYLQGLLQYYDELCQ	DNAH8	641	Q96JB1
LLNIIFYFNPECLYV	GXYLT2	316	A0PJZ3
FYQLVYGLNALLLIC	ABCC11	861	Q96J66
CFVPYNINLILYSLV	LPAR6	241	P43657
FNLYFLLLACSQFVP	ATP9A	81	O75110
NLKYLFYPQFLCEPD	PLA2G10	146	O15496
ALFYLLNPYTILSCV	PIGU	141	Q9H490
LQYFVPLGFILICYL	NPY6R	216	Q99463
LFNLPETYLYACLVD	NT5DC4	126	Q86YG4
VFGYLLPLLLICFCY	GALR1	206	P47211
CLFLLPLSLIFDIYY	DHCR24	36	Q15392
CSLFLPNYVQDKYLL	KNDC1	1521	Q76NI1
YLNCFLSALIEIPAY	SLC22A4	371	Q9H015
LLLFLAIFIYAFPNY	DYSF	2056	O75923
YFIILFICGNYILLN	CACNA1D	731	Q01668
NYPLELLYCLYETQE	NLRP6	616	P59044
LQYLECPQYLRKAFF	SPOUT1	146	Q5T280
ILSLYQNPLCQYNLY	LRRC72	141	A6NJI9
YGFCLLLFYLNFLVV	SLC8B1	556	Q6J4K2
FPANCLSLYFGYLQI	GPR68	36	Q15743
VIYHFFCNIYPLLDL	OR4A8	171	P0C604
LQIQPSQLELFYCLY	NLRP3	621	Q96P20
DYPLLPLNNFLECTY	SEZ6L	296	Q9BYH1
IGICNLLLYFAFYII	SIDT2	721	Q8NBJ9
LTFPLYICCNFLYIS	GMCL2	496	Q8NEA9
YAFFLFENLFNLLLP	SLC39A4	411	Q6P5W5
YAPNYLCLTIFAILL	PMIS2	66	A0A1W2PS18
YYNQLCFLDARFLTP	RHPN1	171	Q8TCX5
LPQANYNLLRYICKF	ARHGAP22	276	Q7Z5H3
GNFYLLYLLFCKVQP	ALG10	106	Q5BKT4
SPCQAVLLYQQFYIL	C12orf56	551	Q8IXR9
LYLQFQKRCLFNYPE	C10orf126	156	Q8N4M7
LVQYFFYKNLCFILP	ATP11C	876	Q8NB49
FYKNLCFILPQFLYQ	ATP11C	881	Q8NB49
LDYRYPLCALQAFAI	TULP1	516	O00294
HIPYLLQLFIDYNLY	REV3L	156	O60673
LPFQVKFFYLCQLAY	TRAM2	156	Q15035
LKNLFGNPVYFLYLC	SLCO1C1	346	Q9NYB5
LLLQCLYLFFVFPLD	WDFY4	166	Q6ZS81
FQYCLPLGFILVCYA	NPY4R2	221	P0DQD5
TCLLYLALDVYFPQI	SYNGR1	81	O43759
GDILLFPYNQLCLAY	PKHD1L1	736	Q86WI1
LELAYCLQKYNVPLF	USP41	121	Q3LFD5
CQILLYAYLDILLYF	UBE4A	286	Q14139
NFLVNLLEPYLFYCL	UGT1A6	211	P19224
SILYLCLGIQQYLFE	ZMYM4	1306	Q5VZL5
YLNSILQVLYFCPGF	USP1	91	O94782