Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

1.47e-075503GO:0030156
GeneOntologyMolecularFunctioncoumarin 7-hydroxylase activity

CYP2A6 CYP2A13

1.84e-053502GO:0008389
GeneOntologyMolecularFunctionnuclear receptor coactivator activity

TRERF1 NCOA3 ZMIZ1

4.80e-0461503GO:0030374
GeneOntologyMolecularFunctionglucosidase activity

LCTL SI

6.32e-0415502GO:0015926
GeneOntologyBiologicalProcessmulticellular organismal reproductive process

RIMBP3 FOXJ2 NDC1 KLF1 RIMBP3C DAZL ZMIZ1 CSMD1 SPAG17 RIMBP3B STK31 TERB2

2.09e-0511945012GO:0048609
GeneOntologyBiologicalProcessspermatogenesis

RIMBP3 FOXJ2 NDC1 RIMBP3C DAZL SPAG17 RIMBP3B STK31 TERB2

6.55e-05744509GO:0007283
GeneOntologyBiologicalProcessmale gamete generation

RIMBP3 FOXJ2 NDC1 RIMBP3C DAZL SPAG17 RIMBP3B STK31 TERB2

7.86e-05762509GO:0048232
GeneOntologyBiologicalProcessneuromuscular synaptic transmission

RIMBP3 RIMBP3C RIMBP3B

9.05e-0536503GO:0007274
GeneOntologyBiologicalProcessgamete generation

RIMBP3 FOXJ2 NDC1 RIMBP3C DAZL ZMIZ1 SPAG17 RIMBP3B STK31 TERB2

1.03e-049825010GO:0007276
GeneOntologyBiologicalProcessdevelopmental process involved in reproduction

RIMBP3 FOXJ2 NCOA3 NDC1 RIMBP3C DAZL CSMD1 SPAG17 RIMBP3B STK31 TERB2

1.46e-0412355011GO:0003006
GeneOntologyBiologicalProcessgerm cell development

RIMBP3 RIMBP3C DAZL SPAG17 RIMBP3B STK31 TERB2

1.53e-04482507GO:0007281
GeneOntologyBiologicalProcessphenylpropanoid metabolic process

CYP2A6 CYP2A13

2.56e-0410502GO:0009698
GeneOntologyBiologicalProcesscoumarin metabolic process

CYP2A6 CYP2A13

2.56e-0410502GO:0009804
GeneOntologyBiologicalProcesscellular process involved in reproduction in multicellular organism

RIMBP3 RIMBP3C DAZL SPAG17 RIMBP3B STK31 TERB2

2.63e-04527507GO:0022412
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3C SPAG17 RIMBP3B

5.68e-0728504GO:0002177
MousePhenodetached acrosome

RIMBP3 RIMBP3C SPAG17 RIMBP3B

7.94e-0644414MP:0009231
MousePhenoabnormal manchette morphology

RIMBP3 RIMBP3C SPAG17 RIMBP3B

8.70e-0645414MP:0009376
MousePhenoectopic manchette

RIMBP3 RIMBP3C RIMBP3B

2.20e-0519413MP:0009377
MousePhenodetached sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

3.00e-0521413MP:0008893
MousePhenoabnormal sperm nucleus morphology

RIMBP3 RIMBP3C SPAG17 RIMBP3B

6.32e-0574414MP:0009232
DomainCyt_P450_E_grp-I_CYP2A-like

CYP2A6 CYP2A13

4.20e-054502IPR008067
DomainSH3_2

RIMBP3 RIMBP3C MYO15A RIMBP3B

8.21e-0586504IPR011511
DomainSH3_2

RIMBP3 RIMBP3C MYO15A RIMBP3B

8.21e-0586504PF07653
DomainELM2

TRERF1 MIDEAS

5.38e-0413502PF01448
DomainELM2

TRERF1 MIDEAS

5.38e-0413502PS51156
DomainELM2_dom

TRERF1 MIDEAS

5.38e-0413502IPR000949
DomainELM2

TRERF1 MIDEAS

5.38e-0413502SM01189
DomainGal_mutarotase_SF_dom

MAN2A2 SI

9.31e-0417502IPR011013
DomainSH3_9

RIMBP3 RIMBP3C RIMBP3B

1.19e-0378503PF14604
DomainSANT_dom

TRERF1 MIDEAS

2.19e-0326502IPR017884
DomainSANT

TRERF1 MIDEAS

2.54e-0328502PS51293
DomainSH3

RIMBP3 RIMBP3C MYO15A RIMBP3B

2.64e-03216504SM00326
DomainSH3

RIMBP3 RIMBP3C MYO15A RIMBP3B

2.64e-03216504PS50002
DomainSH3_domain

RIMBP3 RIMBP3C MYO15A RIMBP3B

2.82e-03220504IPR001452
DomainMyb_DNA-binding

TRERF1 MIDEAS

3.95e-0335502PF00249
DomainMYB_LIKE

TRERF1 MIDEAS

4.64e-0338502PS50090
DomainCyt_P450_E_grp-I

CYP2A6 CYP2A13

6.46e-0345502IPR002401
DomainSANT

TRERF1 MIDEAS

7.93e-0350502SM00717
DomainSANT/Myb

TRERF1 MIDEAS

8.55e-0352502IPR001005
DomainCyt_P450_CS

CYP2A6 CYP2A13

8.87e-0353502IPR017972
DomainGlycoside_hydrolase_SF

LCTL SI

8.87e-0353502IPR017853
DomainVWA

INTS6 CLCA2

9.86e-0356502PF00092
DomainCYTOCHROME_P450

CYP2A6 CYP2A13

1.02e-0257502PS00086
Domain-

CYP2A6 CYP2A13

1.06e-02585021.10.630.10
Domainp450

CYP2A6 CYP2A13

1.06e-0258502PF00067
PathwayREACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION

CYP2A6 CYP2A13 GGT7

2.93e-0526333MM15190
PathwayREACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI

MAN2A2 ST8SIA6 MGAT4C

2.93e-0526333M979
PathwayREACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI

MAN2A2 ST8SIA6 MGAT4C

4.10e-0529333MM15699
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_TO_DNA_ADDUCTS

CYP2A6 CYP2A13

5.29e-055332M47808
PathwayREACTOME_CYP2E1_REACTIONS

CYP2A6 CYP2A13

2.88e-0411332M27130
PathwayREACTOME_CYP2E1_REACTIONS

CYP2A6 CYP2A13

3.46e-0412332MM14847
PathwayREACTOME_N_GLYCAN_ANTENNAE_ELONGATION

ST8SIA6 MGAT4C

5.47e-0415332M966
PathwayREACTOME_N_GLYCAN_ANTENNAE_ELONGATION

ST8SIA6 MGAT4C

5.47e-0415332MM15700
PathwayREACTOME_FATTY_ACIDS

CYP2A6 CYP2A13

7.94e-0418332MM14841
PathwayREACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION

CYP2A13 GGT7

8.86e-0419332M27449
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

1.12e-08450319091768
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP3B

2.79e-08550317855024
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C RIMBP3B

1.01e-061450317662146
Pubmed

Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.

CYP2A6 CYP2A13

2.03e-06250228298240
Pubmed

Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.

CYP2A6 CYP2A13

2.03e-0625026309775
Pubmed

Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.

CYP2A6 CYP2A13

2.03e-06250221418183
Pubmed

Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.

CYP2A6 CYP2A13

2.03e-06250222696418
Pubmed

Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.

CYP2A6 CYP2A13

2.03e-06250222262919
Pubmed

Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.

CYP2A6 CYP2A13

2.03e-06250230876690
Pubmed

CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.

CYP2A6 CYP2A13

2.03e-06250221395539
Pubmed

Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.

CYP2A6 CYP2A13

2.03e-06250225635819
Pubmed

Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.

CYP2A6 CYP2A13

2.03e-06250212162851
Pubmed

Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.

CYP2A6 CYP2A13

2.03e-0625021302041
Pubmed

Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.

CYP2A6 CYP2A13

2.03e-0625028395817
Pubmed

Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.

CYP2A6 CYP2A13

2.03e-06250225804444
Pubmed

Genetic variation between mice in their metabolism of coumarin and its derivatives.

CYP2A6 CYP2A13

2.03e-062502566237
Pubmed

Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.

CYP2A6 CYP2A13

2.03e-0625021520280
Pubmed

Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.

CYP2A6 CYP2A13

2.03e-06250219923441
Pubmed

Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.

CYP2A6 CYP2A13

2.03e-06250223917075
Pubmed

Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.

CYP2A6 CYP2A13

2.03e-06250212499123
Pubmed

Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.

CYP2A6 CYP2A13

2.03e-06250230222954
Pubmed

Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.

CYP2A6 CYP2A13

2.03e-0625028611142
Pubmed

Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.

CYP2A6 CYP2A13

2.03e-0625027543189
Pubmed

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.

CYP2A6 CYP2A13

2.03e-06250227902773
Pubmed

Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.

CYP2A6 CYP2A13

2.03e-06250222497566
Pubmed

Characterization and regulation of sex-specific mouse steroid hydroxylase genes.

CYP2A6 CYP2A13

2.03e-0625022372744
Pubmed

Coumarin toxicity in different strains of mice.

CYP2A6 CYP2A13

2.03e-062502665441
Pubmed

Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.

CYP2A6 CYP2A13

2.03e-06250221473878
Pubmed

Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.

CYP2A6 CYP2A13

2.03e-06250224104196
Pubmed

The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.

CYP2A6 CYP2A13

2.03e-0625027581481
Pubmed

The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.

CYP2A6 CYP2A13

2.03e-06250226363552
Pubmed

Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.

CYP2A6 CYP2A13

2.03e-06250230154104
Pubmed

Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.

CYP2A6 CYP2A13

2.03e-0625022712571
Pubmed

Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.

CYP2A6 CYP2A13

6.07e-06350218602936
Pubmed

Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.

CYP2A6 CYP2A13

6.07e-0635021417950
Pubmed

Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.

CYP2A6 CYP2A13

6.07e-06350218068688
Pubmed

Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.

CYP2A6 CYP2A13

6.07e-06350231645370
Pubmed

Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.

CYP2A6 CYP2A13

6.07e-06350224045421
Pubmed

Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.

CYP2A6 CYP2A13

6.07e-06350232987105
Pubmed

Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.

CYP2A6 CYP2A13

6.07e-0635023219345
Pubmed

Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7.

CYP2A6 CYP2A13

6.07e-0635021973143
Pubmed

Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.

CYP2A6 CYP2A13

6.07e-0635023346244
Pubmed

Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.

CYP2A6 CYP2A13

6.07e-0635027849402
Pubmed

Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.

CYP2A6 CYP2A13

6.07e-06350222217847
Pubmed

Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.

CYP2A6 CYP2A13

6.07e-0635022765478
Pubmed

A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.

CYP2A6 CYP2A13

6.07e-06350221252290
Pubmed

Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.

CYP2A6 CYP2A13

6.07e-06350225478736
Pubmed

Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.

CYP2A6 CYP2A13

6.07e-0635022415518
Pubmed

Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.

CYP2A6 CYP2A13

6.07e-06350220840855
Pubmed

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.

CYP2A6 CYP2A13

6.07e-0635022733794
Pubmed

Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site.

CYP2A6 CYP2A13

6.07e-06350217466327
Pubmed

Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.

CYP2A6 CYP2A13

6.07e-06350222552773
Pubmed

A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.

CYP2A6 CYP2A13

6.07e-0635028297477
Pubmed

Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.

CYP2A6 CYP2A13

6.07e-06350222890016
Pubmed

Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.

CYP2A6 CYP2A13

6.07e-0635028188299
Pubmed

Linkage of open eyelids with linkage group VII of the mouse.

HGS MYO15A

6.07e-0635025690495
Pubmed

Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.

CYP2A6 CYP2A13

6.07e-0635028484736
Pubmed

High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis.

CYP2A6 CYP2A13

6.07e-06350232877213
Pubmed

Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital.

CYP2A6 CYP2A13

6.07e-06350211106424
Pubmed

Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.

CYP2A6 CYP2A13

6.07e-0635028250953
Pubmed

Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation.

CYP2A6 CYP2A13

6.07e-06350224191237
Pubmed

Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2.

CYP2A6 CYP2A13

6.07e-06350217303623
Pubmed

Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model.

CYP2A6 CYP2A13

6.07e-06350223073733
Pubmed

The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.

CYP2A6 CYP2A13

6.07e-0635022703500
Pubmed

Analysis of RNA-protein interactions of mouse liver cytochrome P4502A5 mRNA.

CYP2A6 CYP2A13

1.21e-05450210215609
Pubmed

Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.

CYP2A6 CYP2A13

1.21e-0545029408084
Pubmed

A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.

CYP2A6 CYP2A13

1.21e-0545027565685
Pubmed

Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5.

CYP2A6 CYP2A13

1.21e-05450224494203
Pubmed

Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.

CYP2A6 CYP2A13

1.21e-05450210490589
Pubmed

Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.

CYP2A6 CYP2A13

1.21e-0545021970547
Pubmed

Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5.

CYP2A6 CYP2A13

1.21e-05450216183037
Pubmed

The genes for mouse salivary androgen-binding protein (ABP) subunits alpha and gamma are located on chromosome 7.

CYP2A6 CYP2A13

1.21e-0545023569880
Pubmed

DNA sequence polymorphism in an androgen-regulated gene is associated with alteration in the encoded RNAs.

CYP2A6 CYP2A13

1.21e-0545026188152
Pubmed

Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.

CYP2A6 CYP2A13

1.21e-05450222228748
Pubmed

Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China.

CYP2A6 CYP2A13

2.02e-05550219303722
Pubmed

CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.

CYP2A6 CYP2A13

2.02e-05550237797722
Pubmed

Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody.

CYP2A6 CYP2A13

2.02e-0555026984010
Pubmed

Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis.

CYP2A6 CYP2A13

3.03e-05650228131861
Pubmed

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

CYP2A6 CYP2A13

3.03e-0565027668294
Pubmed

Genetic regulation of coumarin hydroxylase activity in mice. Evidence for single locus control on chromosome.

CYP2A6 CYP2A13

3.03e-056502447675
Pubmed

Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.

CYP2A6 CYP2A13

3.03e-0565028587134
Pubmed

Host airway proteins interact with Staphylococcus aureus during early pneumonia.

CYP2A6 CYP2A13

3.03e-05650218195024
Pubmed

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.

CYP2A6 CYP2A13

4.23e-0575029630227
Pubmed

Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.

CYP2A6 CYP2A13

4.23e-05750214630516
Pubmed

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.

CYP2A6 CYP2A13

5.64e-05850224859727
Pubmed

Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse.

CYP2A6 CYP2A13

5.64e-0585022885848
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TRERF1 NCOA3 FKBP15 NFATC3 IQSEC1 BSN ABLIM3 TNS1

6.43e-0596350828671696
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

NCOA3 EYA1 ZMIZ1 MIDEAS

6.91e-0515250438360978
Pubmed

Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.

CYP2A6 CYP2A13

7.25e-05950237838304
Pubmed

Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.

NCOA3 ST8SIA6

7.25e-05950219176441
Pubmed

Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes.

CYP2A6 CYP2A13

7.25e-0595023917435
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

NCOA3 FKBP15 KLF5 MIDEAS

9.94e-0516750420362541
Pubmed

Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes.

KLF1 KLF5

1.32e-041250215937668
Pubmed

Human transcription factor protein interaction networks.

TRERF1 NCOA3 NFATC3 KLF5 FUBP1 HGS SMG5 ZMIZ1 MIDEAS

1.78e-04142950935140242
Pubmed

Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population.

CYP2A6 CYP2A13

1.82e-041450219290787
Pubmed

Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.

CYP2A6 CYP2A13

2.10e-041550229968852
Pubmed

The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia.

NFATC3 ZMIZ1

2.10e-041550226522984
Pubmed

The role of Pax2 in mouse inner ear development.

EYA1 MYO15A

2.72e-041750215242798
Pubmed

Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.

CYP2A6 CYP2A13

2.72e-041750227197076
Pubmed

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

RIMBP3 NCOA3 FAM168A HGS C1orf94

2.78e-0440250524722188
InteractionR3HDM2 interactions

ARPP21 FAM168A DAZL SMG5 C1orf94

1.37e-05129485int:R3HDM2
InteractionCYP2A7 interactions

CYP2A6 CYP2A13

1.66e-053482int:CYP2A7
InteractionVPS37C interactions

FAM168A KLF1 FUBP1 HGS C1orf94

2.10e-05141485int:VPS37C
InteractionTIAL1 interactions

NCOA3 FAM168A KLF1 FUBP1 DAZL

5.44e-05172485int:TIAL1
InteractionSMAP2 interactions

FAM168A HGS DAZL SMG5 C1orf94

8.49e-05189485int:SMAP2
InteractionKRTAP7-1 interactions

FAM168A HGS C1orf94

1.01e-0438483int:KRTAP7-1
InteractionCLCA2 interactions

NDC1 CLCA2

1.16e-047482int:CLCA2
InteractionDTX2 interactions

RIMBP3 NCOA3 NDC1 FAM168A HGS C1orf94

1.27e-04330486int:DTX2
InteractionMAPK1IP1L interactions

FUBP1 HGS C1orf94

1.68e-0445483int:MAPK1IP1L
Cytoband22q11.21

RIMBP3 RIMBP3C RIMBP3B

2.48e-0411150322q11.21
Cytoband19q13.2

CYP2A6 CYP2A13 ACP7

7.75e-0416450319q13.2
GeneFamilyZinc fingers C2H2-type|Kruppel like factors

KLF1 KLF5

4.01e-0418302624
GeneFamilyCytochrome P450 family 2

CYP2A6 CYP2A13

1.53e-03353021001
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

FKBP15 CSMD1 TNS1

3.28e-03181303694
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

TRERF1 MIDEAS

3.48e-0353302532
CoexpressionTHAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN

FOXJ2 FKBP15 MAN2A2 HGS IQSEC1 RAPGEF1 SMG5 ZMIZ1 NCLN MIDEAS

5.54e-069054910M40865
ToppCellnucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CYP2A6 CYP2A13 ARPP21 CLCA2 EYA1

1.06e-06162505112fa4de685727f6c8bf6fc4afb82de0524070ad
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EYA1 CSMD1 MYO15A SPAG17

1.34e-05129504cbeeaa554da971ba2e4c4b82c85a1d070a45abb8
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ARPP21 KLF5 DAZL MGAT4C

3.36e-05163504218b9ba099cb27aa91c6b73bf89b44895f5dddc3
ToppCellClub_cells-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

CYP2A6 CYP2A13 MINAR1 BSN

3.44e-051645044e25e6362ef793b08de2f4d1dccb6b1fc9c072a5
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ST8SIA6 KLF5 EYA1 GGT7

3.87e-05169504f68195510b91e287fe1507455ca067ece77a3897
ToppCellCOVID-19-Heart-T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

ARPP21 SI CSMD1 AGBL1

4.05e-05171504b2e753e811a7639956994609f73efcdb62d04f82
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Proximal_secretory_2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CYP2A6 CYP2A13 CLCA2 KLF5

4.24e-05173504d1e47c87bd4750801f3531f66a56c5dccb4ea64c
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A6 CYP2A13 CLCA2 EYA1

4.33e-0517450442f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CYP2A13 CLCA2 KLF5 EYA1

4.63e-05177504a4c001a8e44142babf9f24dfe6f7b73a70b11b16
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CYP2A13 CLCA2 KLF5 EYA1

4.63e-05177504363e07b0f347f3716d530a28ead854b98e27d37c
ToppCellControl-Epithelial-Goblet|Control / Disease state, Lineage and Cell class

CYP2A13 CLCA2 KLF5 EYA1

4.94e-051805045293d23b8b8ea587239ffde561b70bad01632521
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARPP21 ECEL1 CSMD1 MGAT4C

5.50e-05185504110d5f02759c8235b14aea524ea47199696094ea
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

ARPP21 KLF5 ABLIM3 MGAT4C

6.10e-051905046e92c78799f34b31d098854503c796edb0dc7f80
ToppCellRV-09._Endothelium_I|World / Chamber and Cluster_Paper

NCOA3 ST8SIA6 RAPGEF1 ABLIM3

6.48e-05193504e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCellRV-09._Endothelium_I|RV / Chamber and Cluster_Paper

NCOA3 ST8SIA6 RAPGEF1 ABLIM3

6.61e-051945047b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ARPP21 CSMD1 MYO15A AGBL1

6.74e-05195504d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellnormal_Lung-Epithelial_cells-Club|normal_Lung / Location, Cell class and cell subclass

CYP2A6 CYP2A13 CLCA2 KLF5

6.74e-05195504b46544ad5af04f4dbc2643637caa3d2d50d922ae
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ARPP21 CSMD1 MYO15A AGBL1

6.74e-0519550419853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellCOVID-19-Epithelial-Club,_Basal_cells|COVID-19 / Condition, Lineage and Cell class

CYP2A13 CLCA2 KLF5 EYA1

6.88e-05196504dd32046067d93b9484cfbf1d7826a436a3d9f0e9
ToppCellLA-09._Endothelium_I|LA / Chamber and Cluster_Paper

NCOA3 ST8SIA6 RAPGEF1 ABLIM3

7.01e-05197504ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

NCOA3 ST8SIA6 RAPGEF1 ABLIM3

7.01e-05197504f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_basal-Suprabasal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CYP2A13 CLCA2 KLF5 EYA1

7.15e-05198504de5987588b9fa9ee8c595ba06d7d844ead0e3c74
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_basal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CYP2A13 CLCA2 KLF5 EYA1

7.29e-05199504995d710d7302272e7951a5a5d766d1039089ee2b
ToppCellHematolymphoid-Endothelial-NOSTRIN|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SLC7A1 IQSEC1 ABLIM3 TNS1

7.44e-05200504032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCellHematolymphoid-Endothelial-NOSTRIN--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SLC7A1 IQSEC1 ABLIM3 TNS1

7.44e-052005047fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCellHematolymphoid-Endothelial-NOSTRIN---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SLC7A1 IQSEC1 ABLIM3 TNS1

7.44e-0520050468fce28690246895fd33354b30960ebcc31aa4cc
ToppCellHematolymphoid-Endothelial-NOSTRIN-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SLC7A1 IQSEC1 ABLIM3 TNS1

7.44e-05200504376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCellHematolymphoid-Endothelial-NOSTRIN----L2-6|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SLC7A1 IQSEC1 ABLIM3 TNS1

7.44e-05200504878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCellHematolymphoid-Endothelial|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SLC7A1 IQSEC1 ABLIM3 TNS1

7.44e-052005047136936d05ab344a560cf159684c881063b5430d
Drugnicotine imine

CYP2A6 CYP2A13

4.35e-062482ctd:C034629
Drugpropargyl ether

CYP2A6 CYP2A13

4.35e-062482ctd:C531209
Drugalpha-nicotyrine

CYP2A6 CYP2A13

4.35e-062482ctd:C008615
DrugHempa

CYP2A6 CYP2A13

4.35e-062482ctd:D006492
DrugN-nitrosoguvacoline

CYP2A6 CYP2A13

4.35e-062482ctd:C036676
Drug2'-methoxyacetophenone

CYP2A6 CYP2A13

1.30e-053482CID000068481
DrugNMPA

CYP2A6 CYP2A13

2.60e-054482CID000132101
DrugN'-nitrosoanatabine

CYP2A6 CYP2A13

2.60e-054482ctd:C032978
DrugN-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide

CYP2A6 CYP2A13

4.33e-055482ctd:C062567
Drugbenzyl selenocyanate

CYP2A6 CYP2A13

4.33e-055482ctd:C054108
DrugD3G

CYP2A6 RAPGEF1

4.33e-055482CID011332763
Drugtroglitazone; Down 200; 10uM; HL60; HT_HG-U133A

SLC7A1 KLF1 NFATC3 MINAR1 MYO15A

5.56e-051954856191_DN
Drug6-Furfurylaminopurine [525-79-1]; Down 200; 18.6uM; HL60; HT_HG-U133A

FKBP15 NDC1 MAN2A2 FAM168A NFATC3

5.70e-051964852511_DN
Drug3-Acetamidocoumarin [779-30-6]; Down 200; 19.6uM; HL60; HT_HG-U133A

FKBP15 NFATC3 FUBP1 IQSEC1 MINAR1

5.70e-051964852941_DN
DrugAceclofenac [89796-99-6]; Down 200; 11.2uM; MCF7; HT_HG-U133A

FKBP15 NFATC3 KLF5 IQSEC1 ABLIM3

5.70e-051964857029_DN
DrugCatechin-(+,-) hydrate [7295-85-4]; Up 200; 13.8uM; MCF7; HT_HG-U133A

SLC7A1 ECEL1 SMG5 MYO15A TNS1

5.83e-051974853351_UP
Drug(R) -Naproxen sodium salt [26159-34-2]; Down 200; 15.8uM; HL60; HT_HG-U133A

SLC7A1 KLF1 MINAR1 SMG5 TNS1

6.12e-051994852533_DN
Drugacenaphthene-1-ol

CYP2A6 CYP2A13

6.49e-056482ctd:C023723
DrugAC1L196J

CYP2A6 CYP2A13

6.49e-056482CID000000415
Drugmenthofuran

CYP2A6 CYP2A13

6.49e-056482ctd:C054487
DrugN'-nitrosoanabasine

CYP2A6 CYP2A13

6.49e-056482ctd:C010257
Drugacenaphthene

CYP2A6 CYP2A13

9.08e-057482ctd:C042552
Drugpolybrominated biphenyl

CYP2A6 CYP2A13 GGT7

1.10e-0444483CID000042948
DrugN-nitrosoguvacoline

CYP2A6 CYP2A13

1.55e-049482CID000062103
Drug3-(methylnitrosamino)propionaldehyde

CYP2A6 CYP2A13

1.55e-049482CID000098533
Drugacenaphthylene

CYP2A6 CYP2A13

1.55e-049482ctd:C042553
Diseaseglucagon-like peptide-1 measurement

CSMD1 AGBL1

1.06e-0410462EFO_0008465
Diseaseapolipoprotein A 1 measurement

CYP2A6 MAN2A2 FAM168A NFATC3 EYA1 ZMIZ1 MIDEAS

3.18e-04848467EFO_0004614
Diseaseacute lymphoblastic leukemia, response to antineoplastic agent

NCOA3 ST8SIA6

4.00e-0419462EFO_0000220, GO_0097327
Diseaseresponse to methotrexate, juvenile idiopathic arthritis

ZMIZ1 CSMD1

4.00e-0419462EFO_0002609, GO_0031427
Diseasearginine measurement

KLF1 CSMD1

5.89e-0423462EFO_0020990
Diseaseerythrocyte measurement

KLF1 BSN TNS1 TERB2

6.88e-04257464EFO_0005047
DiseaseTEMPS-A questionnaire

EYA1 CSMD1

6.97e-0425462EFO_0004783
Diseaselymphocyte measurement

SLC7A1 NFATC3 IQSEC1

8.14e-04117463EFO_0803546
Diseaseparental longevity

CYP2A6 ARPP21 MAN2A2 CSMD1 BSN

1.00e-03494465EFO_0007796
Diseaserheumatoid arthritis, Crohn's disease

ZMIZ1 BSN

1.61e-0338462EFO_0000384, EFO_0000685
DiseaseDisease Exacerbation

CYP2A6 FAM168A IDH3B

2.18e-03165463C0235874
Diseaseanthropometric measurement

EYA1 ZMIZ1 BSN

2.30e-03168463EFO_0004302
Diseaseheart rate variability measurement, response to antipsychotic drug

ECEL1 CSMD1

2.36e-0346462EFO_0008003, GO_0097332
Diseasechronotype measurement

CYP2A6 NFATC3 KLF5 CSMD1 BSN STK31

2.37e-03882466EFO_0008328
DiseaseX-12063 measurement

ARPP21 STK31 AGBL1

3.07e-03186463EFO_0021283
Diseaseinsulin resistance

EYA1 CSMD1

3.84e-0359462EFO_0002614

Protein segments in the cluster

PeptideGeneStartEntry
MNTSIPYQQNPYNPR

ABLIM3

1

O94929
PPFQNGYMINSDYSV

CSMD1

2091

Q96PZ7
PFIGNYLQLNTEQMY

CYP2A6

41

P11509
YQGLYPQQAARMPYQ

C1orf94

481

Q6P1W5
QLGCYSQQVMPYNPQ

C1orf94

501

Q6P1W5
PFYLQLTNMPFINYS

DBF4

231

Q9UBU7
TQQYRPMAPVQYNAQ

ARPP21

651

Q9UBL0
PNSQFNYGMQPTLYS

AGBL1

656

Q96MI9
IFMAQYNYNPFEGPN

RIMBP3B

836

A6NNM3
IFMAQYNYNPFEGPN

RIMBP3C

836

A6NJZ7
QMGNYQEYLKQVPSP

INTS6

586

Q9UL03
FTVYRMQQYDLQGQP

NCLN

46

Q969V3
YQVFNGSREMPYTNP

ACP7

346

Q6ZNF0
PPASLYTNMNVFENY

MGAT4C

341

Q9UBM8
FQPPFQNSQYQDMVA

OR1B1

266

Q8NGR6
QTAMYPIRSAYPQQN

FAM168A

131

Q92567
QMFGIYGPEQVQQYN

MYO15A

1266

Q9UKN7
QQAAYYAQTSPQGMP

FUBP1

621

Q96AE4
MQVLLFENQYYPNGI

IQSEC1

811

Q6DN90
FMAQQKQPVVYGDPY

BSN

1741

Q9UPA5
VMQIYFGDPQIFQQG

GGT7

126

Q9UJ14
NFAQTQYGDPPIYVM

LCTL

396

Q6UWM7
TGMQQATAYATYPQP

EYA1

116

Q99502
QPYAGMQAYAYPQAS

FKBP15

461

Q5T1M5
IPPSNNYYMYQQQQP

FOXJ2

281

Q9P0K8
NAYYLPNKNQMVFPA

ECEL1

571

O95672
PYQFDVLVMPNLYGN

IDH3B

261

O43837
MYPAPQYQGHFQLFR

KLF1

206

Q13351
PFIGNYLQLNTEQMY

CYP2A13

41

Q16696
NFYPMPVMAYIQDAQ

MAN2A2

921

P49641
FENFYSMPQQPSQQP

MIDEAS

271

Q6PJG2
GYQLPVYNYQMPPQW

DAZL

181

Q92904
NHSFEMPYNSQYLNP

MINAR1

301

Q9UPX6
YYQALSVAPQIGMPF

SMG5

201

Q9UPR3
IFMAQYNYNPFEGPN

RIMBP3

836

Q9UFD9
PQQFPYQPNYGMGQQ

NCOA3

1306

Q9Y6Q9
MFPVSQPFVDYPYNQ

ST8SIA6

171

P61647
QQYQQLVGLPAMPAY

SI

336

P14410
TYPFHGYNMGNIPTQ

SPAG17

1016

Q6Q759
YVPGYTANGNIQMNA

CLCA2

711

Q9UQC9
YYPRANLNAVQANMP

STK31

811

Q9BXU1
YSEPQPSMFYQTPQN

RAPGEF1

561

Q13905
RYQPEQPNLVYQMAS

SLC7A1

431

P30825
QAMQPVYTSGIYNIP

TNS1

211

Q9HBL0
YFPLQNYPVNNMVTG

TERB2

161

Q8NHR7
YIAGQQPMYQQMAPS

HGS

731

O14964
SYQPMQTNVVYNGPT

NFATC3

801

Q12968
QPYIQQSMYGRPNYP

ZMIZ1

231

Q9ULJ6
QYGPMGPTQAYNSQF

ZMIZ1

316

Q9ULJ6
QRQGSMQIPQYYQPQ

TRERF1

316

Q96PN7
LGSMSQYYYQEPQQP

TRERF1

371

Q96PN7
YTMPSQFLPQQATYF

KLF5

286

Q13887
VNNMNYLPFPIIQQY

NDC1

186

Q9BTX1