Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	carbon-sulfur lyase activity	CENPVL2 CENPVL3 CENPVL1	3.34e-05	16	80	3	GO:0016846
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH2 MYH3 DNAH12 MYO15A DNAH9	1.12e-04	118	80	5	GO:0003774
GeneOntologyMolecularFunction	MAP kinase kinase kinase kinase activity	MAP4K3 MAP4K5	2.35e-04	6	80	2	GO:0008349
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF135 ZNF630 ZNF526 NR1I2 ZNF792 ZNF648 ZNF432 ETV6 ZNF565 ZNF236 PRDM5 ZNF850 ZNF415 ZNF416	3.88e-04	1244	80	14	GO:0000978
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF135 ZNF630 ZNF526 NR1I2 ZNF792 SAMD11 ZNF648 ZNF432 ETV6 ZNF565 ZNF236 PRDM5 ZNF850 ZNF415 ZNF416	4.32e-04	1412	80	15	GO:0000981
GeneOntologyMolecularFunction	microfilament motor activity	MYH2 MYH3 MYO15A	4.72e-04	38	80	3	GO:0000146
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF135 ZNF630 ZNF526 NR1I2 ZNF792 ZNF648 ZNF432 ETV6 ZNF565 ZNF236 PRDM5 ZNF850 ZNF415 ZNF416	4.81e-04	1271	80	14	GO:0000987
GeneOntologyMolecularFunction	lipoprotein particle receptor binding	HSPG2 LRP1 LRP2	5.10e-04	39	80	3	GO:0070325
Domain	zf-C2H2	ZNF135 ZNF630 ZNF526 ZNF792 ZNF648 ZNF432 ZNF565 ZNF236 PRDM5 ZNF850 ZNF415 ZNF416 ZNF687	3.43e-06	693	75	13	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF135 ZNF630 ZNF526 ZNF792 ZNF648 ZNF432 ZNF565 ZNF236 PRDM5 ZNF850 ZNF415 ZNF416 ZNF687	3.48e-06	694	75	13	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF135 ZNF630 ZNF526 ZNF792 ZNF648 ZNF432 ZNF565 ZNF236 PRDM5 ZNF850 ZNF415 ZNF416 ZNF687	1.15e-05	775	75	13	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF135 ZNF630 ZNF526 ZNF792 ZNF648 ZNF432 ZNF565 ZNF236 PRDM5 ZNF850 ZNF415 ZNF416 ZNF687	1.18e-05	777	75	13	PS00028
Domain	Znf_C2H2-like	ZNF135 ZNF630 ZNF526 ZNF792 ZNF648 ZNF432 ZNF565 ZNF236 PRDM5 ZNF850 ZNF415 ZNF416 ZNF687	1.52e-05	796	75	13	IPR015880
Domain	-	ZNF135 ZNF630 ZNF526 ZNF792 ZNF648 ZNF432 ZNF565 ZNF236 PRDM5 ZNF850 ZNF415 ZNF416	1.55e-05	679	75	12	3.30.160.60
Domain	Znf_C2H2	ZNF135 ZNF630 ZNF526 ZNF792 ZNF648 ZNF432 ZNF565 ZNF236 PRDM5 ZNF850 ZNF415 ZNF416 ZNF687	1.71e-05	805	75	13	IPR007087
Domain	ZnF_C2H2	ZNF135 ZNF630 ZNF526 ZNF792 ZNF648 ZNF432 ZNF565 ZNF236 PRDM5 ZNF850 ZNF415 ZNF416 ZNF687	1.78e-05	808	75	13	SM00355
Domain	Cys-rich_flank_reg_C	IGFALS LRRC4 ADGRA2 ADGRA3 GP5	3.07e-05	90	75	5	IPR000483
Domain	LRRCT	IGFALS LRRC4 ADGRA2 ADGRA3 GP5	3.07e-05	90	75	5	SM00082
Domain	zf-C2H2_6	ZNF135 ZNF526 ZNF792 ZNF432 ZNF236 PRDM5 ZNF850 ZNF416	3.70e-05	314	75	8	PF13912
Domain	-	IGFALS LRCH2 FBXO33 LRRC4 ADGRA2 ADGRA3 NLRP8 GP5	4.33e-05	321	75	8	3.80.10.10
Domain	L_dom-like	IGFALS LRCH2 FBXO33 LRRC4 ADGRA2 ADGRA3 NLRP8 GP5	5.04e-05	328	75	8	IPR032675
Domain	LRR_8	IGFALS LRCH2 LRRC4 ADGRA2 ADGRA3 GP5	6.44e-05	171	75	6	PF13855
Domain	Leu-rich_rpt_typical-subtyp	IGFALS LRCH2 LRRC4 ADGRA2 ADGRA3 GP5	7.80e-05	177	75	6	IPR003591
Domain	LRR_TYP	IGFALS LRCH2 LRRC4 ADGRA2 ADGRA3 GP5	7.80e-05	177	75	6	SM00369
Domain	MAPKKKK	MAP4K3 MAP4K5	9.50e-05	4	75	2	IPR021160
Domain	Leu-rich_rpt	IGFALS LRCH2 LRRC4 ADGRA2 ADGRA3 NLRP8 GP5	1.07e-04	271	75	7	IPR001611
Domain	LRR	IGFALS LRCH2 LRRC4 ADGRA2 ADGRA3 GP5	1.57e-04	201	75	6	PS51450
Domain	LRR_1	IGFALS LRCH2 LRRC4 ADGRA2 ADGRA3 GP5	2.49e-04	219	75	6	PF00560
Domain	GPS	PKD1L2 ADGRA2 ADGRA3	3.40e-04	34	75	3	SM00303
Domain	GPS	PKD1L2 ADGRA2 ADGRA3	3.71e-04	35	75	3	PF01825
Domain	GPS	PKD1L2 ADGRA2 ADGRA3	4.04e-04	36	75	3	PS50221
Domain	GPS	PKD1L2 ADGRA2 ADGRA3	4.38e-04	37	75	3	IPR000203
Domain	Myosin_head_motor_dom	MYH2 MYH3 MYO15A	4.74e-04	38	75	3	IPR001609
Domain	MYOSIN_MOTOR	MYH2 MYH3 MYO15A	4.74e-04	38	75	3	PS51456
Domain	Myosin_head	MYH2 MYH3 MYO15A	4.74e-04	38	75	3	PF00063
Domain	MYSc	MYH2 MYH3 MYO15A	4.74e-04	38	75	3	SM00242
Domain	LDLR_class-A_CS	HSPG2 LRP1 LRP2	5.52e-04	40	75	3	IPR023415
Domain	KRAB	ZNF135 ZNF630 ZNF792 ZNF432 ZNF565 ZNF850 ZNF416	5.82e-04	358	75	7	PS50805
Domain	KRAB	ZNF135 ZNF630 ZNF792 ZNF432 ZNF565 ZNF850 ZNF416	5.82e-04	358	75	7	PF01352
Domain	KRAB	ZNF135 ZNF630 ZNF792 ZNF432 ZNF565 ZNF850 ZNF416	6.95e-04	369	75	7	SM00349
Domain	KRAB	ZNF135 ZNF630 ZNF792 ZNF432 ZNF565 ZNF850 ZNF416	7.07e-04	370	75	7	IPR001909
Domain	Ldl_recept_a	HSPG2 LRP1 LRP2	7.82e-04	45	75	3	PF00057
Domain	FERM_M	PTPN21 MYO15A FRMD1	8.34e-04	46	75	3	PF00373
Domain	-	HSPG2 LRP1 LRP2	8.34e-04	46	75	3	4.10.400.10
Domain	LDLRA_1	HSPG2 LRP1 LRP2	9.45e-04	48	75	3	PS01209
Domain	Ig_I-set	HSPG2 CD101 IL1RL1 LRRC4 ADGRA3	1.00e-03	190	75	5	IPR013098
Domain	I-set	HSPG2 CD101 IL1RL1 LRRC4 ADGRA3	1.00e-03	190	75	5	PF07679
Domain	LDLRA_2	HSPG2 LRP1 LRP2	1.00e-03	49	75	3	PS50068
Domain	FERM_central	PTPN21 MYO15A FRMD1	1.00e-03	49	75	3	IPR019748
Domain	LDrepeatLR_classA_rpt	HSPG2 LRP1 LRP2	1.00e-03	49	75	3	IPR002172
Domain	LDLa	HSPG2 LRP1 LRP2	1.00e-03	49	75	3	SM00192
Domain	FERM_domain	PTPN21 MYO15A FRMD1	1.00e-03	49	75	3	IPR000299
Domain	FERM_1	PTPN21 MYO15A FRMD1	1.06e-03	50	75	3	PS00660
Domain	FERM_2	PTPN21 MYO15A FRMD1	1.06e-03	50	75	3	PS00661
Domain	FERM_3	PTPN21 MYO15A FRMD1	1.06e-03	50	75	3	PS50057
Domain	Band_41_domain	PTPN21 MYO15A FRMD1	1.06e-03	50	75	3	IPR019749
Domain	B41	PTPN21 MYO15A FRMD1	1.06e-03	50	75	3	SM00295
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DNAH9	1.40e-03	14	75	2	IPR024317
Domain	Dynein_heavy_dom-2	DNAH12 DNAH9	1.40e-03	14	75	2	IPR013602
Domain	DHC_N2	DNAH12 DNAH9	1.40e-03	14	75	2	PF08393
Domain	AAA_8	DNAH12 DNAH9	1.40e-03	14	75	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH12 DNAH9	1.40e-03	14	75	2	IPR011704
Domain	Ldl_recept_b	LRP1 LRP2	1.40e-03	14	75	2	PF00058
Domain	LDLRB	LRP1 LRP2	1.40e-03	14	75	2	PS51120
Domain	CNH	MAP4K3 MAP4K5	1.40e-03	14	75	2	SM00036
Domain	AAA_5	DNAH12 DNAH9	1.40e-03	14	75	2	PF07728
Domain	DHC_fam	DNAH12 DNAH9	1.62e-03	15	75	2	IPR026983
Domain	Myosin_N	MYH2 MYH3	1.62e-03	15	75	2	PF02736
Domain	CNH	MAP4K3 MAP4K5	1.62e-03	15	75	2	PF00780
Domain	Dynein_heavy_dom	DNAH12 DNAH9	1.62e-03	15	75	2	IPR004273
Domain	Myosin_N	MYH2 MYH3	1.62e-03	15	75	2	IPR004009
Domain	CNH	MAP4K3 MAP4K5	1.62e-03	15	75	2	PS50219
Domain	CNH_dom	MAP4K3 MAP4K5	1.62e-03	15	75	2	IPR001180
Domain	Dynein_heavy	DNAH12 DNAH9	1.62e-03	15	75	2	PF03028
Domain	LY	LRP1 LRP2	1.62e-03	15	75	2	SM00135
Domain	LDLR_classB_rpt	LRP1 LRP2	1.62e-03	15	75	2	IPR000033
Domain	Myosin_tail_1	MYH2 MYH3	2.34e-03	18	75	2	PF01576
Domain	Myosin_tail	MYH2 MYH3	2.34e-03	18	75	2	IPR002928
Domain	Myosin-like_IQ_dom	MYH2 MYH3	2.60e-03	19	75	2	IPR027401
Domain	-	MYH2 MYH3	2.60e-03	19	75	2	4.10.270.10
Domain	IQ	MYH2 MYH3 MYO15A	2.92e-03	71	75	3	PF00612
Domain	Growth_fac_rcpt_	HSPG2 LRP1 LRP2 PCSK4	3.59e-03	156	75	4	IPR009030
Pubmed	Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow.	CENPVL2 CENPVL3 CENPVL1	2.33e-07	6	80	3	27250503
Pubmed	Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.	LRP1 LRP2	5.23e-06	2	80	2	34445520
Pubmed	Mettl3-mediated m6 A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant-like effects.	LRP2 YTHDC2	1.57e-05	3	80	2	35716070
Pubmed	Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.	ADGRA2 ADGRA3	1.57e-05	3	80	2	15021905
Pubmed	Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis.	LRP1 LRP2	3.13e-05	4	80	2	12413896
Pubmed	Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.	MYH2 MYH3	3.13e-05	4	80	2	20357587
Pubmed	Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.	LRP1 LRP2	3.13e-05	4	80	2	7775583
Pubmed	Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E.	LRP1 LRP2	3.13e-05	4	80	2	11421580
Pubmed	ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association.	LRP1 LRP2	5.20e-05	5	80	2	16101684
Pubmed	Identification of STAT3-independent regulatory effects for protein inhibitor of activated STAT3 by binding to novel transcription factors.	NR1I2 ETV6	5.20e-05	5	80	2	21532337
Pubmed	Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.	MYH2 MYH3	5.20e-05	5	80	2	6196357
Pubmed	Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake.	HSPG2 LRP1	5.20e-05	5	80	2	21289173
Pubmed	Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.	MYH2 MYH3	5.20e-05	5	80	2	3829126
Pubmed	Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome.	MYH2 MYH3	5.20e-05	5	80	2	6879174
Pubmed	Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.	LRP1 LRP2	5.20e-05	5	80	2	19047013
Pubmed	Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.	LRP1 LRP2	5.20e-05	5	80	2	18685438
Pubmed	Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.	LRRC4 ADGRA2 ADGRA3	6.66e-05	34	80	3	18848646
Pubmed	Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples.	PCLO SHC4	7.79e-05	6	80	2	21621269
Pubmed	Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.	MYH2 MYH3	7.79e-05	6	80	2	10444070
Pubmed	Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.	MYH2 MYH3	7.79e-05	6	80	2	1728586
Pubmed	Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.	LRP1 LRP2	7.79e-05	6	80	2	9837937
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH2 MYH3	7.79e-05	6	80	2	10077619
Pubmed	Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.	MYH2 MYH3	7.79e-05	6	80	2	10588881
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH2 MYH3	1.09e-04	7	80	2	35210422
Pubmed	ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.	MYH2 MYH3	1.09e-04	7	80	2	29758057
Pubmed	There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.	ADGRA2 ADGRA3	1.09e-04	7	80	2	12565841
Pubmed	The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.	LRP1 LRP2	1.09e-04	7	80	2	12169628
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH2 MYH3	1.09e-04	7	80	2	16819597
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	DLGAP3 BRPF3 MAP4K3 MAP4K5 LRP2 PANX2	1.14e-04	329	80	6	17474147
Pubmed	Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.	HSPG2 MYH2	1.45e-04	8	80	2	26993635
Pubmed	LDL receptor-related protein as a component of the midkine receptor.	LRP1 LRP2	1.86e-04	9	80	2	10772929
Pubmed	Acceleration of somitic myogenesis in embryos of myogenin promoter-MRF4 transgenic mice.	MYH2 MYH3	2.32e-04	10	80	2	8950513
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	MYH2 MYH3 GTF2H4 MAP4K3 MAP4K5 AKAP11 MAPK7 CCNI ZNF687	2.43e-04	910	80	9	36736316
Pubmed	Extracellular matrix protein composition dynamically changes during murine forelimb development.	HSPG2 MYH2	2.84e-04	11	80	2	38303699
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP1 LRP2	2.84e-04	11	80	2	24639464
Pubmed	Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.	MYH2 MYH3	2.84e-04	11	80	2	16024798
Pubmed	Genetic predictors of medically refractory ulcerative colitis.	GTF2H4 TNFSF15	2.84e-04	11	80	2	20848476
Pubmed	Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development.	MYH2 MYH3	3.40e-04	12	80	2	28600496
Pubmed	Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity.	CYSLTR2 IL1RL1	3.40e-04	12	80	2	32160525
Pubmed	Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.	YTHDC2 PRDM5	4.01e-04	13	80	2	21326311
Pubmed	Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.	MYH2 MYH3	4.01e-04	13	80	2	8404542
Pubmed	Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4.	MYH2 MYH3	4.01e-04	13	80	2	10694423
Pubmed	Ambra1 deficiency impairs mitophagy in skeletal muscle.	MYH2 AMBRA1	4.01e-04	13	80	2	35593053
Pubmed	The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.	MYH2 MYH3	4.01e-04	13	80	2	8948582
Pubmed	Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies.	MYH2 MYH3	4.01e-04	13	80	2	7797078
Pubmed	Functional domains of the FgfrL1 receptor.	MYH3 LRP2	4.67e-04	14	80	2	31923383
Pubmed	Stage-specific association of apolipoprotein A-I and E in developing mouse retina.	LRP1 LRP2	4.67e-04	14	80	2	17389516
Pubmed	Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.	LRP1 LRP2	4.67e-04	14	80	2	15082773
Pubmed	Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice.	MYH2 MYH3	4.67e-04	14	80	2	27184118
Pubmed	Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.	MYH2 MYH3	5.38e-04	15	80	2	24852826
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	GTF2H4 LRCH2 AMBRA1 CCT7 YTHDC2 ZNF687	5.41e-04	440	80	6	34244565
Pubmed	Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H.	MYH2 MYH3	6.95e-04	17	80	2	16124007
Pubmed	Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.	GTF2H4 IGFALS TAF5	7.30e-04	76	80	3	22323595
Pubmed	Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.	LRP1 LRP2	7.81e-04	18	80	2	10827173
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	ST6GAL2 GALC LRP2 IL1RL1 LBP	7.92e-04	313	80	5	20800603
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF526 BRPF3 LRP1 LRP2 AMBRA1 YTHDC2 TAF5 PRDM5 ZNF687	1.05e-03	1116	80	9	31753913
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP1 LRP2	1.07e-03	21	80	2	21337463
Pubmed	A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.	MYH2 MYH3	1.17e-03	22	80	2	24301466
Pubmed	Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.	IL1RL1 TNFSF15	1.17e-03	22	80	2	25642632
Pubmed	Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.	DNAH12 TNFSF15	1.28e-03	23	80	2	20886065
Pubmed	Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity.	GALC ETV6	1.28e-03	23	80	2	22792062
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	LRP2 CCT7 YTHDC2 CARD11	1.38e-03	208	80	4	33230847
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ST6GAL2 BRPF3 AMBRA1 AKAP11 ADGRA2 ZNF687	1.40e-03	529	80	6	14621295
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	MAP4K3 LRP1 LRP2 ECEL1 PLA2G4F TAF5 PCSK4	1.47e-03	730	80	7	34857952
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	ST6GAL2 GCLC LRP2 ETV6	1.48e-03	212	80	4	19521566
Pubmed	Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.	CD101 IL1RL1	1.51e-03	25	80	2	19898481
Pubmed	Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.	CARD11 IL1RL1	1.51e-03	25	80	2	23042114
Pubmed	Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis.	HSPG2 PTPRZ1	1.51e-03	25	80	2	19373938
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	LRP1 LRP2 MAPK7	1.61e-03	100	80	3	25807483
Pubmed	Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.	CYSLTR2 ADGRA2	1.77e-03	27	80	2	24550280
Pubmed	Genetic risk profiling and prediction of disease course in Crohn's disease patients.	DNAH12 TNFSF15	1.90e-03	28	80	2	19422935
Pubmed	Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy.	HSPG2 MYH2	1.90e-03	28	80	2	25179606
Pubmed	The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.	ADGRA2 ADGRA3	2.04e-03	29	80	2	15203201
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF135 ZNF526 ZNF792 CPT1C ZNF432 ZNF565 ZNF850 ZNF415 ZNF416 NLRP8	4.26e-05	1192	80	10	chr19q13
Cytoband	Xp11.22	CENPVL2 CENPVL3 CENPVL1	1.19e-04	54	80	3	Xp11.22
Cytoband	7q31.3	PTPRZ1 LRRC4	3.10e-04	15	80	2	7q31.3
Cytoband	3p14.3	CACNA1D DNAH12	1.26e-03	30	80	2	3p14.3
Cytoband	Ensembl 112 genes in cytogenetic band chrXp11	ZNF630 CENPVL2 CENPVL3 CENPVL1	4.33e-03	377	80	4	chrXp11
Cytoband	Ensembl 112 genes in cytogenetic band chr14q31	GALC PTPN21	4.81e-03	59	80	2	chr14q31
Cytoband	19q13.12	ZNF565 ZNF850	7.08e-03	72	80	2	19q13.12
Cytoband	1p36.33	SAMD11 CFAP74	8.06e-03	77	80	2	1p36.33
Cytoband	19q13.4	ZNF135 ZNF416	8.47e-03	79	80	2	19q13.4
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF135 ZNF630 ZNF526 ZNF792 ZNF648 ZNF432 ZNF565 ZNF236 PRDM5 ZNF850 ZNF415 ZNF416	4.09e-06	718	61	12	28
GeneFamily	Immunoglobulin like domain containing\|Adhesion G protein-coupled receptors, subfamily A	ADGRA2 ADGRA3	3.35e-05	3	61	2	911
GeneFamily	Mitogen-activated protein kinase kinase kinase kinases	MAP4K3 MAP4K5	1.11e-04	5	61	2	655
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	HSPG2 CD101 IL1RL1 LRRC4 ADGRA3	2.09e-04	161	61	5	593
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PTPN21 MYO15A FRMD1	6.40e-04	50	61	3	1293
GeneFamily	Low density lipoprotein receptors	LRP1 LRP2	8.53e-04	13	61	2	634
GeneFamily	Myosin heavy chains	MYH2 MYH3	1.14e-03	15	61	2	1098
GeneFamily	Dyneins, axonemal	DNAH12 DNAH9	1.47e-03	17	61	2	536
GeneFamily	Immunoglobulin like domain containing	HSPG2 CD101 IL1RL1 ADGRA2	4.09e-03	193	61	4	594
Disease	distal arthrogryposis (implicated_via_orthology)	MYH2 MYH3 ECEL1	7.02e-06	15	75	3	DOID:0050646 (implicated_via_orthology)
Disease	tubulointerstitial nephritis antigen-like measurement	HSPG2 MAP4K5	1.91e-05	3	75	2	EFO_0803197
Disease	Distal arthrogryposis	MYH3 ECEL1	2.27e-04	9	75	2	cv:C0265213
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH2 MYH3	2.83e-04	10	75	2	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH2 MYH3	2.83e-04	10	75	2	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH2 MYH3	2.83e-04	10	75	2	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH2 MYH3	2.83e-04	10	75	2	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH2 MYH3	2.83e-04	10	75	2	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH2 MYH3	2.83e-04	10	75	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH2 MYH3	2.83e-04	10	75	2	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH2 MYH3	2.83e-04	10	75	2	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH2 MYH3	4.14e-04	12	75	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH2 MYH3	4.14e-04	12	75	2	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH2 MYH3	4.88e-04	13	75	2	DOID:397 (implicated_via_orthology)
Disease	phosphorus measurement	FGF23 ETV6	7.48e-04	16	75	2	EFO_0004861
Disease	migraine without aura, susceptibility to, 4	FGF23 LRP1	7.48e-04	16	75	2	MONDO_0011847
Disease	cardiomyopathy (implicated_via_orthology)	MYH2 MYH3 LRP1	7.96e-04	71	75	3	DOID:0050700 (implicated_via_orthology)
Disease	alcohol consumption measurement	CACNA1D ST6GAL2 DLGAP3 MAP4K5 PCLO AKAP11 SRR FBXO33 MYO15A WDPCP	1.16e-03	1242	75	10	EFO_0007878
Disease	fetal hemoglobin measurement	YTHDC2 PRDM5	1.30e-03	21	75	2	EFO_0004576
Disease	Antimigraine preparation use measurement	FGF23 LRP1	1.30e-03	21	75	2	EFO_0009939
Disease	Metabolic Syndrome X	NR1I2 LBP	1.30e-03	21	75	2	C0524620
Disease	Schizophrenia	GCLC PTPRZ1 LRP1 LRP2 AMBRA1 SRR ZNF565 PTPN21	1.79e-03	883	75	8	C0036341
Disease	upper respiratory tract disorder	IL1RL1 FBXO33	2.31e-03	28	75	2	MONDO_0004867
Disease	triacylglycerol 54:7 measurement	MAP4K5 TXNDC11	2.31e-03	28	75	2	EFO_0010425
Disease	lysophosphatidylethanolamine 20:4 measurement	MAP4K5 FBXO33	2.48e-03	29	75	2	EFO_0010370

Protein segments in the cluster

Peptide	Gene	Start	Entry
RAHLTVVRQTPTQHF	TNFSF15	96	O95150
HTHHLIPSLRQVVFQ	ADGRA2	246	Q96PE1
THHIPVNVTLRRIAH	ADGRA3	681	Q8IWK6
LHIFHAIAVSTRPQL	CCNI	151	Q14094
GVPLIRRLHSHLQSQ	BRPF3	516	Q9ULD4
LTSNQLTHLPHRLFQ	IGFALS	441	P35858
RIFHLSVPQIHVNLD	AKAP11	1631	Q9UKA4
QHRHFLVPASRFTLL	CENPVL1	166	A0A0U1RR11
SQPVRRTPLLHNFLH	AMBRA1	231	Q9C0C7
HQVHGSRLRLLQVTP	HSPG2	2481	P98160
PFSLQRHLLIHNSER	PRDM5	416	Q9NQX1
IELLHRSRSPITTNH	ETV6	176	P41212
QIIHSSQPLTLEHVR	MAPK7	146	Q13164
KLLQHPFVTQHLTRS	MAP4K3	266	Q8IVH8
IFHRNHRSPVTLLAA	LBP	251	P18428
HVLSHVNIQRLIASP	NLRP8	531	Q86W28
VLHPHLTRFLQDVSR	MYO15A	3151	Q9UKN7
SNRHVVLSQDIPHIF	LRP1	3221	Q07954
HVPLQRLSLLVHNVS	FBXO33	331	Q7Z6M2
RLVHSRPLSQHQEQI	PCLO	4466	Q9Y6V0
FHLRHRGVVQQSLTP	PCSK4	71	Q6UW60
PLRHATIFSQQFLTH	OR52A5	131	Q9H2C5
TNLRSTHPHFVRCII	MYH2	666	Q9UKX2
PFAIVITQQHQIHRS	NCOA5	251	Q9HCD5
NKHPRFSTLTRNIRH	GCLC	181	P48506
ARNQIFSNLHIIHPT	DNAH12	196	Q6ZR08
VSIQRQINHPFVHSL	RSKR	156	Q96LW2
VLSHASRHPRISVLN	LRRC4	391	Q9HBW1
RQTLVNTTHRPFDIH	LRP2	3441	P98164
QHTQRLLRIQDIHPF	NR1I2	406	O75469
LFRHLHTVSQILPQV	PTPRZ1	831	P23471
LHFPLVNRTFRTHLA	PLA2G4F	761	Q68DD2
SQLIRSTPHRVLHNY	ECEL1	386	O95672
LLPRHSQRHSQPTVL	PKD1L2	1161	Q7Z442
NPDLITRRVHHSVQT	PTPN21	591	Q16825
SRFLHLQSPFLTQVH	CPT1C	661	Q8TCG5
PTHRHILQQRILNGS	WDPCP	676	O95876
ASHQLHLRVRPTLQQ	FRMD1	326	Q8N878
SRRHIFILTPQITHN	IL1RL1	441	Q01638
FQPASSHIFHQLIRI	CD101	581	Q93033
VFTPHLNSNLHRLVQ	COG1	856	Q8WTW3
QHRHFLVPASRFTLL	CENPVL2	166	P0DPI3
LIHFNTPIPRRHTRS	FGF23	166	Q9GZV9
RHLLQHPTLSQRVLV	B3GALNT2	76	Q8NCR0
QHRHFLVPASRFTLL	CENPVL3	166	A0A0U1RRI6
SPSRIRHLVHSVQKL	DLGAP3	166	O95886
TELQFHRNHIRSIAP	GP5	221	P40197
TINPRLQRHFSVFVL	DNAH9	2601	Q9NYC9
HHFTLRQVLNQRPIT	GALC	526	P54803
THHTLRALRNTLQPE	CARD11	861	Q9BXL7
LQQTNTTHRPLHVQR	CACNA1D	1701	Q01668
IRTEISLHNHSLLPQ	CFAP74	936	Q9C0B2
LANHIRPRSVASIHV	LRCH2	681	Q5VUJ6
FEPHAIIRHTIRSTN	MAP4K5	311	Q9Y4K4
ILSRNATHPLLHINT	PANX2	616	Q96RD6
KSTPVVHLHFTRRNL	TAF5	776	Q15542
NPTIILAHIRQSHVT	MAPKAP1	6	Q9BPZ7
IRIINSQILTNPSHH	ST6GAL2	341	Q96JF0
LHPQIIIRAFRTATQ	CCT7	116	Q99832
NLPTLISSVHRSRHL	SAMD11	106	Q96NU1
SNLRTTHPHFVRCII	MYH3	661	P11055
HINIRDSIHLTPVLT	SRR	16	Q9GZT4
VHPFRLLHVTSIRSA	CYSLTR2	141	Q9NS75
AQQIIHFLRTRAHPV	GTF2H4	361	Q92759
PTLRSRQDRHFLQHL	SHC4	171	Q6S5L8
FIRSSQLTEHQRIHP	ZNF565	496	Q8N9K5
FTQITPLIQHQRTHT	ZNF135	391	P52742
FSQLAPLIQHQRIHT	ZNF135	531	P52742
TFPRKTQLIIHQRTH	ZNF630	411	Q2M218
FSQKSPLIIHQRIHT	ZNF630	496	Q2M218
LHRHFNTSLVFPREV	TXNDC11	321	Q6PKC3
HNTKHAVRSLIQRFP	YTHDC2	121	Q9H6S0
FSVRPNLFRHQIIHT	ZNF415	581	Q09FC8
SLVVHQRIHTTARPY	ZNF416	396	Q9BWM5
FPLKSRLIVHQRTHT	ZNF432	466	O94892
FNQRPTLIRHQKIHI	ZNF792	571	Q3KQV3
FQKPSQLTRHIRIHT	ZNF236	206	Q9UL36
AFAQPSRLVRHQRIH	ZNF648	456	Q5T619
HQRVHARARTLTLQP	ZNF526	591	Q8TF50
LLSSHFDQHLLPQRV	ZNF687	841	Q8N1G0
SALRLHQRLPHFQLS	TMEM33	66	P57088
SFTLRSALIQHRPVH	ZNF850	821	A8MQ14